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PTPN22

Gene Description:   protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Synonyms:   PEP, PTPN22, 70zpep, LYP1, Ptpn8, LYP2, LYP, Ptpn22, PTPN8 Orthologs:   Human PTPN22 (protein-coding), Mouse Ptpn22 (protein-coding), Rat Ptpn22 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 4

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
1p13.2	Human	chr1:113818477..114658477	0.84	73	rs2476601

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm3	Rat	chr2:197256223..242256223	45.00	528
Idd18.2	Mouse	chr3:100949733..108222063	7.27	704

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 1p13.2 Orthologous Region	Mouse	chr3:103411764..104131346	0.72	11
Human 1p13.2 Orthologous Region	Rat	chr2:198839041..199551300	0.71	10
Iddm26	Rat	chr2:181710214..222281918	40.57	2603

(Human) GRCh37 - chr1:114356433..114414381 (57.95 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr3:103663718..103716170 (52.45 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr2:199083186..199144309 (61.12 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                     no data   no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for PTPN22: The PTPN22 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs PTPN22   CDH2   IntAct  empirical  19167335  PTPN22   CSK   HPRD, MINT  empirical  9582365  PTPN22   ERBB2   IntAct  empirical  19167335  PTPN22   GHR   IntAct  empirical  19167335  PTPN22   GRB2   HPRD, MINT, BioGRID  empirical  11882361  PTPN22   LCK   HPRD, IntAct  empirical  16461343  19167335  PTPN22   NTRK1   IntAct  empirical  19167335  PTPN22   PDGFRB   IntAct  empirical  19167335  PTPN22   PDPK1   IntAct  empirical  19167335  PTPN22   PRKCD   HPRD  empirical  18056643  PTPN22   VAV1   HPRD, IntAct  empirical  16461343  PTPN22   VCP   IntAct  empirical  16461343  PTPN22   WAS   IntAct  empirical  19167335  PTPN22   ZAP70   HPRD, IntAct  empirical  16461343  PTPN22   CBL   HPRD  empirical  10068674  PTPN22   CD3E   HPRD, IntAct  empirical  16461343  PTPN22   CD247   HPRD, IntAct  empirical  16461343

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 18   Protein tyrosine phosphatase activity GO:0004725 Protein binding GO:0005515 Nucleus GO:0005634 Cytoplasm GO:0005737 Protein dephosphorylation GO:0006470 Internal side of plasma membrane GO:0009898 Hydrolase activity GO:0016787 SH3 domain binding GO:0017124 Kinase binding GO:0019900 T cell differentiation GO:0030217 Regulation of natural killer cell proliferation GO:0032817 Peptidyl-tyrosine dephosphorylation GO:0035335 Phosphoanandamide dephosphorylation GO:0035644 Regulation of innate immune response GO:0045088 Perinuclear region of cytoplasm GO:0048471 Regulation of B cell receptor signaling pathway GO:0050855 Negative regulation of T cell receptor signaling pathway GO:0050860 Negative regulation of T cell activation GO:0050868

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 18 Protein tyrosine phosphatase activity GO:0004725 Protein binding GO:0005515 Nucleus GO:0005634 Cytoplasm GO:0005737 Protein dephosphorylation GO:0006470 Internal side of plasma membrane GO:0009898 Hydrolase activity GO:0016787 SH3 domain binding GO:0017124 Kinase binding GO:0019900 T cell differentiation GO:0030217 Regulation of natural killer cell proliferation GO:0032817 Peptidyl-tyrosine dephosphorylation GO:0035335 Phosphoanandamide dephosphorylation GO:0035644 Regulation of innate immune response GO:0045088 Perinuclear region of cytoplasm GO:0048471 Regulation of B cell receptor signaling pathway GO:0050855 Negative regulation of T cell receptor signaling pathway GO:0050860 Negative regulation of T cell activation GO:0050868

Type 1 Diabetes Publications: 90

• Association of PTPN22 1858T/T genotype with type 1 diabetes, Graves' disease but not with rheumatoid arthritis in Russian population.
  Zhebrun D, Kudryashova Y, Babenko A, Maslyansky A, Kunitskaya N, Popcova D, Klushina A, Grineva E, Kostareva A, Shlyakhto E
  Aging (Albany NY). 2011
  PubMed ID: 21467606
   
  
• Does the relative risk for type 1 diabetes conferred by HLA-DQ, INS, and PTPN22 polymorphisms vary with maternal age, birth weight, or cesarean section?
  Stene LC, Rønningen KS, Undlien DE, Joner G
  Pediatr Diabetes. 2011
  PubMed ID: 21352425
   
  
• The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes.
  Nielsen LB, Pörksen S, Andersen ML, Fredheim S, Svensson J, Hougaard P, Vanelli M, Åman J, Mortensen HB, Hansen L, Hvidoere Study Group on Childhood Diabetes
  BMC Med Genet. 2011
  PubMed ID: 21429197
   
  
• Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.
  Aminkeng F, Weets I, Van Autreve JE, Koeleman BP, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ, Belgian Diabetes Registry
  Hum Immunol. 2010
  PubMed ID: 20849903
   
  
• A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
  Genes Immun. 2010
  PubMed ID: 20962850
   
  
• Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.
  Andersen MK, Lundgren V, Turunen JA, Forsblom C, Isomaa B, Groop PH, Groop L, Tuomi T
  Diabetes Care. 2010
  PubMed ID: 20805278
   
  
• Genome-wide searching of rare genetic variants in WTCCC data.
  Feng T, Zhu X
  Hum Genet. 2010
  PubMed ID: 20549515
   
  
• Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population.
  Ban Y, Tozaki T, Taniyama M, Nakano Y, Ban Y, Ban Y, Hirano T
  Thyroid. 2010
  PubMed ID: 20615141
   
  
• Association of PTPN22 haplotypes with type 1 diabetes in the Japanese population.
  Taniyama M, Maruyama T, Tozaki T, Nakano Y, Ban Y
  Hum Immunol. 2010
  PubMed ID: 20510318
   
  
• PTPN22 1858T allele is associated with younger age at onset of type 1 diabetes and is not related to subsequent thyroid autoimmunity.
  Kordonouri O, Hartmann R, Badenhoop K, Kahles H, Ilonen J
  Hum Immunol. 2010
  PubMed ID: 20438787
   
  
• In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
  Qu HQ, Bradfield JP, Li Q, Kim C, Frackelton E, Grant SF, Hakonarson H, Polychronakos C
  Hum Mol Genet. 2010
  PubMed ID: 20378605
   
  
• PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients.
  Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, Fichna P, Nowak J
  Int J Immunogenet. 2010
  PubMed ID: 20518841
   
  
• Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.
  Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, Annese V, Dubinsky M, Rotter JI, Russell RK, Bradfield JP, Sleiman PM, Glessner JT, Walters T, Hou C, Kim C, Frackelton EC, Garris M, Doran J, Romano C, Catassi C, Van Limbergen J, Guthery SL, Denson L, Piccoli D, Silverberg MS, Stanley CA, Monos D, Wilson DC, Griffiths A, Grant SF, Satsangi J, Polychronakos C, Hakonarson H
  Hum Mol Genet. 2010
  PubMed ID: 20176734
   
  
• The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.
  Maziarz M, Janer M, Roach JC, Hagopian W, Palmer JP, Deutsch K, Sanjeevi CB, Kockum I, Breslow N, Lernmark A
  Genes Immun. 2010
  PubMed ID: 20445565
   
  
• Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population.
  Chagastelles PC, Romitti M, Trein MR, Bandinelli E, Tschiedel B, Nardi NB
  Tissue Antigens. 2010
  PubMed ID: 20331840
   
  
• Identification of a variant form of tyrosine phosphatase LYP.
  Wang S, Dong H, Han J, Ho WT, Fu X, Zhao ZJ
  BMC Mol Biol. 2010
  PubMed ID: 21044313
   
  
• The PTPN22 locus and rheumatoid arthritis: no evidence for an effect on risk independent of Arg620Trp.
  Wan Taib WR, Smyth DJ, Merriman ME, Dalbeth N, Gow PJ, Harrison AA, Highton J, Jones PB, Stamp L, Steer S, Todd JA, Merriman TR
  PLoS One. 2010
  PubMed ID: 20975833
   
  
• Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
  Pierce BL, Ahsan H
  Hum Hered. 2010
  PubMed ID: 20203524
   
  
• Allelic variants in the PHTF1-PTPN22, C12orf30 and CD226 regions as candidate susceptibility factors for the type 1 diabetes in the Estonian population.
  Douroudis K, Kisand K, Nemvalts V, Rajasalu T, Uibo R
  BMC Med Genet. 2010
  PubMed ID: 20089178
   
  
• Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.
  Klinker MW, Schiller JJ, Magnuson VL, Wang T, Basken J, Veth K, Pearce KI, Kinnunen L, Harjutsalo V, Wang X, Tuomilehto J, Sarti C, Ghosh S
  Immunogenetics. 2009
  PubMed ID: 20033399
   
  
• rs2476601 T allele (R620W) defines high-risk PTPN22 type I diabetes-associated haplotypes with preliminary evidence for an additional protective haplotype.
  Steck AK, Baschal EE, Jasinski JM, Boehm BO, Bottini N, Concannon P, Julier C, Morahan G, Noble JA, Polychronakos C, She JX, Eisenbarth GS, Type I Diabetes Genetics Consortium
  Genes Immun. 2009
  PubMed ID: 19956096
   
  
• An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms.
  Stene LC, Rønningen KS, Bjørnvold M, Undlien DE, Joner G
  Pediatr Diabetes. 2009
  PubMed ID: 19895409
   
  
• [Association of the C1858T polymorphism of the PTPN22 gene with type 1 diabetes]
  Lavrikova EIu, Nikitin AG, Seregin IuA, Zil'berman LI, Tsitlidze NM, Kuraeva TL, Peterkova VA, Dedov II, Nosikov VV
  Mol Biol (Mosk). 2009
  PubMed ID: 20088380
   
  
• Genetic heterogeneity in latent autoimmune diabetes (LADA) is linked to a varying degree of autoimmune activity. Results from the Nord-Trondelag Health Study.
  Pettersen E, Skorpen F, Kvaløy K, Midthjell K, Grill V
  Diabetes. 2009
  PubMed ID: 19833889
   
  
• Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians.
  Korolija M, Renar IP, Hadžija M, Medvidović EP, Pavković P, Jokić M, Hadžija MP
  Diabetes Res Clin Pract. 2009
  PubMed ID: 19815302
   
  
• Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.
  Lempainen J, Vaarala O, Mäkelä M, Veijola R, Simell O, Knip M, Hermann R, Ilonen J
  J Autoimmun. 2009
  PubMed ID: 19473815
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes.
  Nejentsev S, Walker N, Riches D, Egholm M, Todd JA
  Science. 2009
  PubMed ID: 19264985
   
  
• Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis.
  Liao KP, Gunnarsson M, Källberg H, Ding B, Plenge RM, Padyukov L, Karlson EW, Klareskog L, Askling J, Alfredsson L
  Arthritis Rheum. 2009
  PubMed ID: 19248096
   
  
• In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation.
  Wu S, Bottini M, Rickert RC, Mustelin T, Tautz L
  ChemMedChem. 2009
  PubMed ID: 19177473
   
  
• Do non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children with High-Risk HLA-DR,DQ Genotypes?
  Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ
  Diabetes. 2009
  PubMed ID: 19188433
   
  
• The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes.
  Dultz G, Matheis N, Dittmar M, Röhrig B, Bender K, Kahaly GJ
  Thyroid. 2009
  PubMed ID: 19090780
   
  
• AUTOIMMUNE THYROIDITIS AND DIABETES: DISSECTING THE JOINT GENETIC SUSCEPTIBILITY IN A LARGE COHORT OF MULTIPLEX FAMILIES.
  Villano MJ, Huber AK, Greenberg DA, Golden BK, Concepcion E, Tomer Y
  J Clin Endocrinol Metab. 2009
  PubMed ID: 19141582
   
  
• Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
  Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG
  BMC Med Genet. 2009
  PubMed ID: 19951419
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  
• Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
  Bakhtadze E, Cervin C, Lindholm E, Borg H, Nilsson P, Arnqvist HJ, Bolinder J, Eriksson JW, Gudbjörnsdottir S, Nyström L, Agardh CD, Landin-Olsson M, Sundkvist G, Groop LC
  Diabetologia. 2008
  PubMed ID: 18839133
   
  
• Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.
  Douroudis K, Prans E, Haller K, Nemvalts V, Rajasalu T, Tillmann V, Kisand K, Uibo R
  Tissue Antigens. 2008
  PubMed ID: 18764813
   
  
• Reduced CD4(+)T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant.
  Aarnisalo J, Treszl A, Svec P, Marttila J, Oling V, Simell O, Knip M, Körner A, Madacsy L, Vasarhelyi B, Ilonen J, Hermann R
  J Autoimmun. 2008
  PubMed ID: 18299186
   
  
• Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
  Butty V, Campbell C, Mathis D, Benoist C, the Diabetes Prevention Trial-Type 1 Study Group
  Diabetes. 2008
  PubMed ID: 18556337
   
  
• Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the Caucasian population.
  Dieudé P, Teixeira VH, Pierlot C, Cornélis F, Petit-Teixeira E, ECRAF
  Ann Rheum Dis. 2008
  PubMed ID: 18474664
   
  
• PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes.
  Smyth DJ, Cooper JD, Howson JM, Walker NM, Plagnol V, Stevens H, Clayton DG, Todd JA
  Diabetes. 2008
  PubMed ID: 18305142
   
  
• The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control.
  Petrone A, Spoletini M, Zampetti S, Capizzi M, Zavarella S, Osborn J, Pozzilli P, Buzzetti R, Immunotherapy Diabetes (IMDIAB) Group
  Diabetes Care. 2008
  PubMed ID: 18252906
   
  
• No evidence for association of PTPN22 R620W functional variant C1858T with type 1 diabetes in Asian Indians.
  Baniasadi V, Das SN
  J Cell Mol Med. 2008
  PubMed ID: 18194462
   
  
• Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
  Cervin C, Lyssenko V, Bakhtadze E, Lindholm E, Nilsson P, Tuomi T, Cilio CM, Groop L
  Diabetes. 2008
  PubMed ID: 18310307
   
  
• Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.
  Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC
  Diabetologia. 2008
  PubMed ID: 18292987
   
  
• The functional R620W variant of the PTPN22 gene is associated with celiac disease.
  Santin I, Castellanos-Rubio A, Aransay AM, Castaño L, Vitoria JC, Bilbao JR
  Tissue Antigens. 2008
  PubMed ID: 18194365
   
  
• Association between PTPN22 C1858T and type 1 diabetes: a replication in continental Italy.
  Saccucci P, Del Duca E, Rapini N, Verrotti A, Piccinini S, Maccari A, Canu G, Angelini F, Fontana L, Giannini C, Chiarelli F, Manca Bitti ML, Bottini N
  Tissue Antigens. 2008
  PubMed ID: 18179648
   
  
• The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3.
  Petrone A, Suraci C, Capizzi M, Giaccari A, Bosi E, Tiberti C, Cossu E, Pozzilli P, Falorni A, Buzzetti R, NIRAD Study Group
  Diabetes Care. 2008
  PubMed ID: 18056891
   
  
• FCRL3 -169CT functional polymorphism in type 1 diabetes and autoimmunity traits.
  Duchatelet S, Caillat-Zucman S, Dubois-Laforgue D, Blanc H, Timsit J, Julier C
  Biomed Pharmacother. 2008
  PubMed ID: 17961971
   
  
• Further evidence of a primary, causal association of the PTPN22 620W variant with type 1 diabetes.
  Zoledziewska M, Perra C, Orrù V, Moi L, Frongia P, Congia M, Bottini N, Cucca F
  Diabetes. 2008
  PubMed ID: 17934143
   
  
• The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases.
  Eike MC, Nordang GB, Karlsen TH, Boberg KM, Vatn MH, Dahl-Jørgensen K, Rønningen KS, Joner G, Flatø B, Bergquist A, Thorsby E, Førre O, Kvien TK, Undlien DE, Lie BA
  Ann Rheum Dis. 2007
  PubMed ID: 18065500
   
  
• Sex-specific association of the human PTPN22 1858T-allele with type 1 diabetes.
  Nielsen C, Hansen D, Husby S, Lillevang ST
  Int J Immunogenet. 2007
  PubMed ID: 18001305
   
  
• Protein tyrosine phosphatase PTPN22 in human autoimmunity.
  Vang T, Miletic AV, Bottini N, Mustelin T
  Autoimmunity. 2007
  PubMed ID: 17729039
   
  
• The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.
  Viken MK, Olsson M, Flåm ST, Førre O, Kvien TK, Thorsby E, Lie BA
  Tissue Antigens. 2007
  PubMed ID: 17661906
   
  
• Genetics of type 1 diabetes in Asian and Caucasian populations.
  Ikegami H, Kawabata Y, Noso S, Fujisawa T, Ogihara T
  Diabetes Res Clin Pract. 2007
  PubMed ID: 17452059
   
  
• A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
  Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C
  Nature. 2007
  PubMed ID: 17632545
   
  
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
  Wellcome Trust Case Control Consortium
  Nature. 2007
  PubMed ID: 17554300
   
  
• No independent role of the -1123 G>C and+2740 A>G variants in the association of PTPN22 with type 1 diabetes and juvenile idiopathic arthritis in two Caucasian populations.
  Cinek O, Hradsky O, Ahmedov G, Slavcev A, Kolouskova S, Kulich M, Sumnik Z
  Diabetes Res Clin Pract. 2007
  PubMed ID: 17000021
   
  
• A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
  Howson JM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA
  Diabetologia. 2007
  PubMed ID: 17334650
   
  
• PTPN22 R620W functional variant in type 1 diabetes and autoimmunity related traits.
  Chelala C, Duchatelet S, Joffret ML, Bergholdt R, Dubois-Laforgue D, Ghandil P, Pociot F, Caillat-Zucman S, Timsit J, Julier C
  Diabetes. 2007
  PubMed ID: 17259401
   
  
• Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.
  Michou L, Lasbleiz S, Rat AC, Migliorini P, Balsa A, Westhovens R, Barrera P, Alves H, Pierlot C, Glikmans E, Garnier S, Dausset J, Vaz C, Fernandes M, Petit-Teixeira E, Lemaire I, Pascual-Salcedo D, Bombardieri S, Dequeker J, Radstake TR, Van Riel P, van de Putte L, Lopes-Vaz A, Prum B, Bardin T, Dieudé P, Cornélis F, European Consortium on Rheumatoid Arthritis Families
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17237219
   
  
• Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population.
  Santiago JL, Martínez A, de la Calle H, Fernández-Arquero M, Figueredo MA, de la Concha EG, Urcelay E
  BMC Med Genet. 2007
  PubMed ID: 17697317
   
  
• Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.
  Ikegami H, Fujisawa T, Kawabata Y, Noso S, Ogihara T
  Ann N Y Acad Sci. 2006
  PubMed ID: 17130532
   
  
• Association of the PTPN22/LYP gene with type 1 diabetes.
  Steck AK, Liu SY, McFann K, Barriga KJ, Babu SR, Eisenbarth GS, Rewers MJ, She JX
  Pediatr Diabetes. 2006
  PubMed ID: 17054449
   
  
• A haplotype-based analysis of the PTPN22 locus in type 1 diabetes.
  Onengut-Gumuscu S, Buckner JH, Concannon P
  Diabetes. 2006
  PubMed ID: 17003357
   
  
• Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population.
  Wipff J, Allanore Y, Kahan A, Meyer O, Mouthon L, Guillevin L, Pierlot C, Glikmans E, Bardin T, Boileau C, Cornélis F, Dieudé P
  Ann Rheum Dis. 2006
  PubMed ID: 16464986
   
  
• Protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene R620W variant and sporadic idiopathic hypoparathyroidism in Asian Indians.
  Ray D, Tomar N, Gupta N, Goswami R
  Int J Immunogenet. 2006
  PubMed ID: 16893384
   
  
• Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
  Kaufman KM, Kelly JA, Herring BJ, Adler AJ, Glenn SB, Namjou B, Frank SG, Dawson SL, Bruner GR, James JA, Harley JB
  Arthritis Rheum. 2006
  PubMed ID: 16868974
   
  
• Role of PTPN22 in type 1 diabetes and other autoimmune diseases.
  Bottini N, Vang T, Cucca F, Mustelin T
  Semin Immunol. 2006
  PubMed ID: 16697661
   
  
• Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
  Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP
  J Allergy Clin Immunol. 2006
  PubMed ID: 16750991
   
  
• Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
  Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J
  Diabetologia. 2006
  PubMed ID: 16614815
   
  
• The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.
  Fedetz M, Matesanz F, Caro-Maldonado A, Smirnov II, Chvorostinka VN, Moiseenko TA, Alcina A
  Tissue Antigens. 2006
  PubMed ID: 16671953
   
  
• Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations.
  Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Uga M, Kurihara S, Kawabata Y, Tanaka S, Kanazawa Y, Lee I, Eguchi K
  Am J Med Genet A. 2006
  PubMed ID: 16470599
   
  
• Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.
  De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD
  Eur J Hum Genet. 2006
  PubMed ID: 16391555
   
  
• Sex-specific association of PTPN22 1858T with type 1 diabetes but not with Hashimoto's thyroiditis or Addison's disease in the German population.
  Kahles H, Ramos-Lopez E, Lange B, Zwermann O, Reincke M, Badenhoop K
  Eur J Endocrinol. 2005
  PubMed ID: 16322396
   
  
• The PTPN22 620W allele is a risk factor for Wegener's granulomatosis.
  Jagiello P, Aries P, Arning L, Wagenleiter SE, Csernok E, Hellmich B, Gross WL, Epplen JT
  Arthritis Rheum. 2005
  PubMed ID: 16320352
   
  
• Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant.
  Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N
  Nat Genet. 2005
  PubMed ID: 16273109
   
  
• A general autoimmunity gene (PTPN22) is not associated with inflammatory bowel disease in a British population.
  Prescott NJ, Fisher SA, Onnie C, Pattni R, Steer S, Sanderson J, Forbes A, Lewis CM, Mathew CG
  Tissue Antigens. 2005
  PubMed ID: 16185328
   
  
• PTPN22 C1858T polymorphism in Colombian patients with autoimmune diseases.
  Gomez LM, Anaya JM, Gonzalez CI, Pineda-Tamayo R, Otero W, Arango A, Martín J
  Genes Immun. 2005
  PubMed ID: 16163373
   
  
• Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
  Zhernakova A, Eerligh P, Wijmenga C, Barrera P, Roep BO, Koeleman BP
  Genes Immun. 2005
  PubMed ID: 15875058
   
  
• Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
  van Oene M, Wintle RF, Liu X, Yazdanpanah M, Gu X, Newman B, Kwan A, Johnson B, Owen J, Greer W, Mosher D, Maksymowych W, Keystone E, Rubin LA, Amos CI, Siminovitch KA
  Arthritis Rheum. 2005
  PubMed ID: 15986374
   
  
• Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene.
  Hinks A, Barton A, John S, Bruce I, Hawkins C, Griffiths CE, Donn R, Thomson W, Silman A, Worthington J
  Arthritis Rheum. 2005
  PubMed ID: 15934099
   
  
• Genetic association between a lymphoid tyrosine phosphatase (PTPN22) and type 1 diabetes.
  Zheng W, She JX
  Diabetes. 2005
  PubMed ID: 15734872
   
  
• Ethnic differences in allele frequency of autoimmune-disease-associated SNPs.
  Mori M, Yamada R, Kobayashi K, Kawaida R, Yamamoto K
  J Hum Genet. 2005
  PubMed ID: 15883854
   
  
• Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes.
  Ladner MB, Bottini N, Valdes AM, Noble JA
  Hum Immunol. 2005
  PubMed ID: 15620463
   
  
• The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease.
  Velaga MR, Wilson V, Jennings CE, Owen CJ, Herington S, Donaldson PT, Ball SG, James RA, Quinton R, Perros P, Pearce SH
  J Clin Endocrinol Metab. 2004
  PubMed ID: 15531553
   
  
• Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
  Smyth D, Cooper JD, Collins JE, Heward JM, Franklyn JA, Howson JM, Vella A, Nutland S, Rance HE, Maier L, Barratt BJ, Guja C, Ionescu-Tîrgoviste C, Savage DA, Dunger DB, Widmer B, Strachan DP, Ring SM, Walker N, Clayton DG, Twells RC, Gough SC, Todd JA
  Diabetes. 2004
  PubMed ID: 15504986
   
  
• Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
  Kyogoku C, Langefeld CD, Ortmann WA, Lee A, Selby S, Carlton VE, Chang M, Ramos P, Baechler EC, Batliwalla FM, Novitzke J, Williams AH, Gillett C, Rodine P, Graham RR, Ardlie KG, Gaffney PM, Moser KL, Petri M, Begovich AB, Gregersen PK, Behrens TW
  Am J Hum Genet. 2004
  PubMed ID: 15273934
   
  
• A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
  Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, Spoerke JM, Conn MT, Chang M, Chang SY, Saiki RK, Catanese JJ, Leong DU, Garcia VE, McAllister LB, Jeffery DA, Lee AT, Batliwalla F, Remmers E, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, Gregersen PK
  Am J Hum Genet. 2004
  PubMed ID: 15208781
   
  
• A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
  Bottini N, Musumeci L, Alonso A, Rahmouni S, Nika K, Rostamkhani M, MacMurray J, Meloni GF, Lucarelli P, Pellecchia M, Eisenbarth GS, Comings D, Mustelin T
  Nat Genet. 2004
  PubMed ID: 15004560
   
  

Publications: 234

• PTPN22 1858T is not a risk factor for North American pemphigus vulgaris.
  Sachdev A, Bhanusali DG, Patterson KC, Zamora MB, Ghuman A, Gerlach JA, Sinha AA
  Exp Dermatol. 2011
  PubMed ID: 21585555
   
  
• Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.
  Eliopoulos E, Zervou MI, Andreou A, Dimopoulou K, Cosmidis N, Voloudakis G, Mysirlaki H, Vazgiourakis V, Sidiropoulos P, Niewold TB, Boumpas DT, Goulielmos GN
  Lupus. 2011
  PubMed ID: 21543514
   
  
• Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis.
  Diaz-Gallo LM, Gourh P, Broen J, Simeon C, Fonollosa V, Ortego-Centeno N, Agarwal S, Vonk MC, Coenen M, Riemekasten G, Hunzelmann N, Hesselstrand R, Tan FK, Reveille JD, Assassi S, García-Hernandez FJ, Carreira P, Camps MT, Fernandez-Nebro A, de la Peña PG, Nearney T, Hilda D, González-Gay MA, Airo P, Beretta L, Scorza R, Herrick A, Worthington J, Pros A, Gómez-Gracia I, Trapiella L, Espinosa G, Castellvi I, Witte T, de Keyser F, Vanthuyne M, Mayes MD, Radstake TR, Arnett FC, Martin J, Rueda B
  Ann Rheum Dis. 2011
  PubMed ID: 21131644
   
  
• The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples.
  Rodríguez-Rodríguez L, Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J
  Arthritis Rheum. 2011
  PubMed ID: 21279993
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy.
  Majorczyk E, Pawlik A, Kuśnierczyk P
  Int Immunopharmacol. 2010
  PubMed ID: 20888443
   
  
• Genetically determined amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.
  Sanchez E, Webb RD, Rasmussen A, Kelly JA, Riba L, Kaufman KM, Garcia-de la Torre I, Moctezuma JF, Maradiaga-Ceceña MA, Cardiel-Rios MH, Acevedo E, Cucho-Venegas M, Garcia MA, Gamron S, Pons-Estel BA, Vasconcelos C, Martin J, Tusié-Luna T, Harley JB, Richardson B, Sawalha AH, Alarcón-Riquelme ME
  Arthritis Rheum. 2010
  PubMed ID: 20848568
   
  
• The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in caucasian case-control samples.
  Rodríguez-Rodríguez L, Wan Taib WR, Topless R, Steer S, González-Escribano MF, Balsa A, Pascual-Salcedo D, González-Gay MA, Raya E, Fernandez-Gutierrez B, González-Álvaro I, Bottini N, Witte T, Viken MK, Coenen MJ, van Riel PL, Franke B, den Heijer M, Radstake TR, Wordsworth P, Lie BA, Merriman TR, Martín J
  Arthritis Rheum. 2010
  PubMed ID: 21080357
   
  
• The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: A meta-analysis update.
  Lea W, Lee YH
  Lupus. 2010
  PubMed ID: 21078766
   
  
• Analysis of Immune Regulatory Genes' Copy Number Variants in Graves' Disease.
  Huber AK, Concepcion ES, Gandhi A, Menconi F, Smith EP, Keddache M, Tomer Y
  Thyroid. 2010
  PubMed ID: 21054240
   
  
• Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study.
  Berglin E, Kokkonen H, Einarsdottir E, Agren A, Rantapää Dahlqvist S
  Scand J Rheumatol. 2010
  PubMed ID: 20560812
   
  
• Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
  Arthritis Rheum. 2010
  PubMed ID: 20973039
   
  
• A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
  Plant D, Farragher T, Flynn E, Martin P, Eyre S, Bunn D, Worthington J, Symmons D, Barton A, Thomson W
  Pharmacogenomics J. 2010
  PubMed ID: 20921970
   
  
• [Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients].
  Peng XB, Ou LN
  Nan Fang Yi Ke Da Xue Xue Bao. 2010
  PubMed ID: 20965855
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Association of the PTPN22 gene (-1123G > C) polymorphism with rheumatoid arthritis in Chinese patients.
  Feng X, Li YZ, Zhang Y, Bao SM, Tong DW, Zhang SL, Hu CJ
  Tissue Antigens. 2010
  PubMed ID: 20604892
   
  
• Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
  Webb R, Kelly JA, Somers EC, Hughes T, Kaufman KM, Sanchez E, Nath SK, Bruner G, Alarcón-Riquelme ME, Gilkeson GS, Kamen DL, Richardson BC, Harley JB, Sawalha AH
  Ann Rheum Dis. 2010
  PubMed ID: 20881011
   
  
• Lack of association of PTPN22, STAT4 and TRAF1/C5 gene polymorphisms with cardiovascular risk in rheumatoid arthritis.
  Palomino-Morales R, Gonzalez-Juanatey C, Vazquez-Rodriguez TR, Rodriguez L, Miranda-Filloy JA, Pascual-Salcedo D, Balsa A, Fernandez-Gutierrez B, Llorca J, Martin J, Gonzalez-Gay MA
  Clin Exp Rheumatol. 2010
  PubMed ID: 20822712
   
  
• PTPN22 polymorphism is related to autoimmune disease risk in patients with Turner syndrome.
  Bianco B, Verreschi IT, Oliveira KC, Guedes AD, Galera BB, Galera MF, Barbosa CP, Lipay MV
  Scand J Immunol. 2010
  PubMed ID: 20696024
   
  
• Increased representation of the PTPN22 mutation in patients with immune thrombocytopenia.
  D'Silva KJ, Zamora MB, Gerlach J, Schwartz KA
  J Thromb Haemost. 2010
  PubMed ID: 20553389
   
  
• Genetic variants in the prediction of rheumatoid arthritis.
  van der Helm-van Mil AH, Toes RE, Huizinga TW
  Ann Rheum Dis. 2010
  PubMed ID: 20439292
   
  
• The PTPN22 susceptibility risk variant is not associated with the rate of joint destruction in anti-citrullinated protein antibody-positive rheumatoid arthritis.
  van Nies JA, Knevel R, Daha N, van der Linden MP, Gregersen PK, Kern M, le Cessie S, Houwing-Duistermaat JJ, Huizinga TW, Toes RE, van der Helm-van Mil AH
  Ann Rheum Dis. 2010
  PubMed ID: 20388740
   
  
• Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.
  Fiorillo E, Orrú V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N
  J Biol Chem. 2010
  PubMed ID: 20538612
   
  
• Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
  Plant D, Flynn E, Mbarek H, Dieudé P, Cornelis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Johansen JS, Ørnbjerg LM, Hetland ML, Klareskog L, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Worthington J
  Ann Rheum Dis. 2010
  PubMed ID: 20498205
   
  
• Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.
  Tamai M, Kawakami A, Iwamoto N, Arima K, Aoyagi K, Eguchi K
  Scand J Rheumatol. 2010
  PubMed ID: 20476860
   
  
• PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.
  Morgan AR, Han DY, Huebner C, Lam WJ, Fraser AG, Ferguson LR
  Tissue Antigens. 2010
  PubMed ID: 20403149
   
  
• PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility.
  Pradhan V, Borse V, Ghosh K
  J Postgrad Med. 2010
  PubMed ID: 20739780
   
  
• Clinical characteristics and PTPN22 1858C/T variant analysis in Jordanian Arab vitiligo patients.
  Alkhateeb A, Qarqaz F, Al-Sabah J, Al Rashaideh T
  Mol Diagn Ther. 2010
  PubMed ID: 20560680
   
  
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
  Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
  Nat Genet. 2010
  PubMed ID: 20453842
   
  
• Lymphoid tyrosine phosphatase and autoimmunity: human genetics rediscovers tyrosine phosphatases.
  Stanford SM, Mustelin TM, Bottini N
  Semin Immunopathol. 2010
  PubMed ID: 20204370
   
  
• Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
  Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S
  Inflamm Bowel Dis. 2010
  PubMed ID: 19760754
   
  
• PTPN22 gene regulates natural killer cell proliferation during in vitro expansion.
  Douroudis K, Shcherbakova A, Everaus H, Aints A
  Tissue Antigens. 2010
  PubMed ID: 20522204
   
  
• Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
  Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM, Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA
  N Engl J Med. 2010
  PubMed ID: 20410501
   
  
• HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians.
  Coppo P, Busson M, Veyradier A, Wynckel A, Poullin P, Azoulay E, Galicier L, Loiseau P, French Reference Centre For Thrombotic Microangiopathies
  J Thromb Haemost. 2010
  PubMed ID: 20141578
   
  
• Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis.
  Briggs FB, Ramsay PP, Madden E, Norris JM, Holers VM, Mikuls TR, Sokka T, Seldin MF, Gregersen PK, Criswell LA, Barcellos LF
  Genes Immun. 2010
  PubMed ID: 20090771
   
  
• The PTPN22 R620W polymorphism is not associated with systemic rheumatic diseases in South Africans.
  Tikly M, Govind N, Frost J, Ramsay M
  Rheumatology (Oxford). 2010
  PubMed ID: 20008090
   
  
• Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
  Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
  Ann Rheum Dis. 2010
  PubMed ID: 20233754
   
  
• Gold(I) phosphine mediated selective inhibition of lymphoid tyrosine phosphatase.
  Karver MR, Krishnamurthy D, Bottini N, Barrios AM
  J Inorg Biochem. 2010
  PubMed ID: 20083307
   
  
• PTPN22 C1858T polymorphism in women with endometriosis.
  Gomes FM, Bianco B, Teles JS, Christofolini DM, de Souza AM, Guedes AD, Barbosa CP
  Am J Reprod Immunol. 2010
  PubMed ID: 20070289
   
  
• Allele and haplotype frequency distribution in PTPN22 gene across variable ethnic groups: Implications for genetic association studies for autoimmune diseases.
  Lins TC, Vieira RG, Grattapaglia D, Pereira RW
  Autoimmunity. 2010
  PubMed ID: 20166877
   
  
• The protein tyrosine phosphatase, non-receptor type 22 R620W polymorphism does not confer susceptibility to psoriasis in the genetic homogeneous population of Crete.
  Zervou MI, Castro-Giner F, Sidiropoulos P, Boumpas DT, Tosca AD, Krueger-Krasagakis S
  Genet Test Mol Biomarkers. 2010
  PubMed ID: 20039785
   
  
• Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease.
  Gu LQ, Zhu W, Zhao SX, Zhao L, Zhang MJ, Cui B, Song HD, Ning G, Zhao YJ
  Clin Endocrinol (Oxf). 2010
  PubMed ID: 19438904
   
  
• Lymphoid tyrosine phosphatase R620W variant and inflammatory bowel disease in Tunisia.
  Sfar I, Ben Aleya W, Mouelhi L, Aouadi H, Ben Rhomdhane T, Makhlouf M, Ayed-Jendoubi S, Gargaoui H, Najjar T, Ben Abdallah T, Ayed K, Gorgi Y
  World J Gastroenterol. 2010
  PubMed ID: 20101775
   
  
• Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort.
  Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD, Steiner L, Erlich HA, Gooi HC, Barton A, Worthington J, Emery P, UKRAG Consortium, YEAR Consortium
  Arthritis Res Ther. 2010
  PubMed ID: 20353580
   
  
• Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are associated with humoral responses to early food allergens in children.
  Savilahti EM, Ilonen J, Kiviniemi M, Saarinen KM, Vaarala O, Savilahti E
  Int Arch Allergy Immunol. 2010
  PubMed ID: 20016199
   
  
• Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease.
  Lopez-Escamez JA, Saenz-Lopez P, Acosta L, Moreno A, Gazquez I, Perez-Garrigues H, Lopez-Nevot A, Lopez-Nevot MA
  Laryngoscope. 2010
  PubMed ID: 19780033
   
  
• Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophilia A.
  Bafunno V, Santacroce R, Chetta M, D'Andrea G, Pisanelli D, Sessa F, Trotta T, Tagariello G, Peyvandi F, Margaglione M
  Haemophilia. 2009
  PubMed ID: 20015215
   
  
• Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.
  Dubinsky MC, Mei L, Friedman M, Dhere T, Haritunians T, Hakonarson H, Kim C, Glessner J, Targan SR, McGovern DP, Taylor KD, Rotter JI
  Inflamm Bowel Dis. 2009
  PubMed ID: 20014019
   
  
• Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
  Mahdi H, Fisher BA, Källberg H, Plant D, Malmström V, Rönnelid J, Charles P, Ding B, Alfredsson L, Padyukov L, Symmons DP, Venables PJ, Klareskog L, Lundberg K
  Nat Genet. 2009
  PubMed ID: 19898480
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.
  McClure A, Lunt M, Eyre S, Ke X, Thomson W, Hinks A, Bowes J, Gibbons L, Plant D, Wilson AG, Marinou I, Morgan AW, Emery P, BIRAC consortium, Steer S, Hocking LJ, Reid DM, Wordsworth P, Harrison P, Worthington J, Barton A
  Rheumatology (Oxford). 2009
  PubMed ID: 19741008
   
  
• Common and different genetic background for rheumatoid arthritis and coeliac disease.
  Coenen MJ, Trynka G, Heskamp S, Franke B, van Diemen CC, Smolonska J, van Leeuwen M, Brouwer E, Boezen MH, Postma DS, Platteel M, Zanen P, Lammers JW, Groen HJ, Mali WP, Mulder CJ, Tack GJ, Verbeek WH, Wolters VM, Houwen RH, Mearin ML, van Heel DA, Radstake TR, van Riel PL, Wijmenga C, Barrera P, Zhernakova A
  Hum Mol Genet. 2009
  PubMed ID: 19648290
   
  
• Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.
  Morgan AW, Thomson W, Martin SG, Yorkshire Early Arthritis Register Consortium, Carter AM, UK Rheumatoid Arthritis Genetics Consortium, Erlich HA, Barton A, Hocking L, Reid DM, Harrison P, Wordsworth P, Steer S, Worthington J, Emery P, Wilson AG, Barrett JH
  Arthritis Rheum. 2009
  PubMed ID: 19714585
   
  
• Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population.
  Lamsyah H, Rueda B, Baassi L, Elaouad R, Bottini N, Sadki K, Martin J
  Tissue Antigens. 2009
  PubMed ID: 19563523
   
  
• Juvenile onset Systemic Lupus Erythematosus thyroid dysfunction: a subgroup with mild disease?
  Parente Costa L, Bonfá E, Martinago CD, de Oliveira RM, Carvalho JF, Pereira RM
  J Autoimmun. 2009
  PubMed ID: 19419839
   
  
• The PTPN22(gain-of-function)+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.
  Chuang WY, Ströbel P, Belharazem D, Rieckmann P, Toyka KV, Nix W, Schalke B, Gold R, Kiefer R, Klinker E, Opitz A, Inoue M, Kuo TT, Müller-Hermelink HK, Marx A
  Genes Immun. 2009
  PubMed ID: 19693092
   
  
• Regulation of lymphoid tyrosine phosphatase activity: inhibition of the catalytic domain by the proximal interdomain.
  Liu Y, Stanford SM, Jog SP, Fiorillo E, Orrú V, Comai L, Bottini N
  Biochemistry. 2009
  PubMed ID: 19586056
   
  
• Tacrolimus differentially regulates the proliferation of conventional and regulatory CD4(+) T cells.
  Kogina K, Shoda H, Yamaguchi Y, Tsuno NH, Takahashi K, Fujio K, Yamamoto K
  Mol Cells. 2009
  PubMed ID: 19714314
   
  
• Lack of association with rheumatoid arthritis of selected polymorphisms in 4 candidate genes: CFH, CD209, eotaxin-3, and MHC2TA.
  Dieguez-Gonzalez R, Akar S, Calaza M, Gonzalez-Alvaro I, Fernandez-Gutierrez B, Lamas JR, de la Serna AR, Caliz R, Blanco FJ, Pascual-Salcedo D, Velloso ML, Perez-Pampin E, Pablos JL, Navarro F, Narvaez J, Lopez-Longo FJ, Herrero-Beaumont G, Gomez-Reino JJ, Gonzalez A
  J Rheumatol. 2009
  PubMed ID: 19567623
   
  
• Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a ten-year prospective study.
  Syversen SW, Goll GL, van der Heijde D, Landewé R, Lie BA, Odegard S, Uhlig T, Gaarder PI, Kvien TK
  Ann Rheum Dis. 2009
  PubMed ID: 19648126
   
  
• REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
  Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL, Xie G, Begovich AB, Siminovitch KA
  Nat Genet. 2009
  PubMed ID: 19503088
   
  
• The autoimmunity-related polymorphism PTPN22 1858C/T is associated with anti-titin antibody-positive myasthenia gravis.
  Greve B, Hoffmann P, Illes Z, Rozsa C, Berger K, Weissert R, Melms A
  Hum Immunol. 2009
  PubMed ID: 19406179
   
  
• The Role of Polymorphic Protein Tyrosine Phosphatase Non-Receptor Type 22 in Leprosy.
  Rani R, Singh A, Israni N, Singh A, Sharma P, Kar HK
  J Invest Dermatol. 2009
  PubMed ID: 19516267
   
  
• Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation .
  Tsai SJ, Sen U, Zhao L, Greenleaf WB, Dasgupta J, Fiorillo E, Orrú V, Bottini N, Chen XS
  Biochemistry. 2009
  PubMed ID: 19371084
   
  
• PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population.
  Burr ML, Naseem H, Hinks A, Eyre S, Gibbons L, Bowes J, Consortium B, Consortium Y, Wilson AG, Maxwell J, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth BP, Harrison P, Thomson W, Worthington J, Barton A
  Ann Rheum Dis. 2009
  PubMed ID: 19470526
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• The R620W polymorphism of the protein tyrosine phosphatase 22 gene in autoimmune thyroid diseases and rheumatoid arthritis in the Tunisian population.
  Chabchoub G, Teixiera EP, Maalej A, Ben Hamad M, Bahloul Z, Cornelis F, Ayadi H
  Ann Hum Biol. 2009
  PubMed ID: 19343596
   
  
• No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey.
  Sahin N, Gunduz F, Inanc N, Direskeneli H, Saruhan-Direskeneli G
  Rheumatol Int. 2009
  PubMed ID: 19357851
   
  
• PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
  Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A
  J Immunol. 2009
  PubMed ID: 19299707
   
  
• Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.
  Arechiga AF, Habib T, He Y, Zhang X, Zhang ZY, Funk A, Buckner JH
  J Immunol. 2009
  PubMed ID: 19265110
   
  
• The PTPN22 C1858T (R620W) functional polymorphism in kidney transplantation.
  Sfar I, Gorgi Y, Aouadi H, Maklouf M, Ben Romdhane T, Jendoubi-Ayed S, Bardi R, Abderrahim E, Ben Abdallah T, Ayed K
  Transplant Proc. 2009
  PubMed ID: 19328948
   
  
• Genetic risk factors for rheumatoid arthritis differ in caucasian and Korean populations.
  Lee HS, Korman BD, Le JM, Kastner DL, Remmers EF, Gregersen PK, Bae SC
  Arthritis Rheum. 2009
  PubMed ID: 19180477
   
  
• Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
  Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
  Am J Obstet Gynecol. 2009
  PubMed ID: 19019335
   
  
• A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
  Orrú V, Tsai SJ, Rueda B, Fiorillo E, Stanford SM, Dasgupta J, Hartiala J, Zhao L, Ortego-Centeno N, D'Alfonso S, Italian Collaborative Group, Arnett FC, Wu H, Gonzalez-Gay MA, Tsao BP, Pons-Estel B, Alarcon-Riquelme ME, He Y, Zhang ZY, Allayee H, Chen XS, Martin J, Bottini N
  Hum Mol Genet. 2009
  PubMed ID: 18981062
   
  
• Large-scale structural analysis of the classical human protein tyrosine phosphatome.
  Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
  Cell. 2009
  PubMed ID: 19167335
   
  
• Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis.
  Sfar I, Dhaouadi T, Habibi I, Abdelmoula L, Makhlouf M, Ben Romdhane T, Jendoubi-Ayed S, Aouadi H, Ben Abdallah T, Ayed K, Zouari R, Lakhoua-Gorgi Y
  Arch Inst Pasteur Tunis. 2009
  PubMed ID: 20707220
   
  
• If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
  Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
  Reprod Biol Endocrinol. 2009
  PubMed ID: 19527514
   
  
• Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients.
  Horie Y, Kitaichi N, Katsuyama Y, Yoshida K, Miura T, Ota M, Asukata Y, Inoko H, Mizuki N, Ishida S, Ohno S
  Mol Vis. 2009
  PubMed ID: 19503742
   
  
• A new PCR-RFLP assay for -1123 G>C polymorphism in the PTPN22 gene: allele and genotype frequencies in a western Mexican population.
  Padilla-Gutiérrez JR, Valle Y, Vázquez-Del Mercado M, Maldonado M, Muñoz-Valle JF
  Clin Chem Lab Med. 2009
  PubMed ID: 19327125
   
  
• PTPN22/LYP 1858C>T gene polymorphism and susceptibility to endometriosis in a Polish population.
  Płoski R, Dziunycz P, Kostrzewa G, Roszkowski PI, Barcz E, Zabek J, Milewski Ł, Kamiński P, Malejczyk J
  J Reprod Immunol. 2009
  PubMed ID: 19237203
   
  
• Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
  Martin TM, Bye L, Modi N, Stanford MR, Vaughan R, Smith JR, Wade NK, Mackensen F, Suhler EB, Rosenbaum JT, Wallace GR
  Mol Vis. 2009
  PubMed ID: 19180256
   
  
• The phagosomal proteome in interferon-gamma-activated macrophages.
  Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
  Immunity. 2009
  PubMed ID: 19144319
   
  
• PTPN22 C1858T polymorphism and human brucellosis.
  Bravo MJ, Colmenero JD, Queipo-Ortuño MI, Morata P, Orozco G, Martin J, Alonso A, Caballero A
  Scand J Infect Dis. 2009
  PubMed ID: 19107641
   
  
• PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection.
  Montes-Cano MA, García-Lozano JR, Aguilar-Reina J, Romero-Gómez M, Barroso N, Nuñez-Roldán A, Martín J, González-Escribano MF
  Viral Immunol. 2008
  PubMed ID: 19115939
   
  
• Association of the lymphoid protein tyrosine phosphatase, R620W variant, with chronic mucocutaneous candidiasis.
  Nahum A, Bates A, Sharfe N, Roifman CM
  J Allergy Clin Immunol. 2008
  PubMed ID: 19084113
   
  
• PTPN22 allele polymorphisms in 15 Chinese populations.
  Zhang ZH, Chen F, Zhang XL, Jin Y, Bai J, Fu SB
  Int J Immunogenet. 2008
  PubMed ID: 19046301
   
  
• Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
  Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA
  Nat Genet. 2008
  PubMed ID: 18978792
   
  
• Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects.
  Farago B, Talian GC, Komlosi K, Nagy G, Berki T, Gyetvai A, Szekanecz Z, Nyarady Z, Kiss CG, Nemeth P, Czirjak L, Melegh B
  Rheumatol Int. 2008
  PubMed ID: 19034456
   
  
• Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients.
  Pazár B, Gergely P, Nagy ZB, Gombos T, Pozsonyi E, Rajczy K, Balogh Z, Sevcic K, Orbán I, Szodoray P, Poór G
  Clin Exp Rheumatol. 2008
  PubMed ID: 19210888
   
  
• Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland.
  Piotrowski P, Lianeri M, Wudarski M, Lacki JK, Jagodziński PP
  Clin Exp Rheumatol. 2008
  PubMed ID: 19210878
   
  
• Further Genetic Evidence for Three Psoriasis-Risk Genes: ADAM33, CDKAL1, and PTPN22.
  Li Y, Liao W, Chang M, Schrodi SJ, Bui N, Catanese JJ, Poon A, Matsunami N, Callis-Duffin KP, Leppert MF, Bowcock AM, Kwok PY, Krueger GG, Begovich AB
  J Invest Dermatol. 2008
  PubMed ID: 18923449
   
  
• Smoking and inflammatory diseases.
  Vittecoq O, Lequerré T, Goëb V, Le Loët X, Abdesselam TA, Klemmer N
  Best Pract Res Clin Rheumatol. 2008
  PubMed ID: 19028372
   
  
• The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients.
  Chinoy H, Platt H, Lamb JA, Betteridge Z, Gunawardena H, Fertig N, Varsani H, Davidson J, Oddis CV, McHugh NJ, Wedderburn LR, Ollier WE, Cooper RG, UK Adult Onset Myositis Immunogenetic Collaboration and the Juvenile Dermatomyositis Research Group
  Arthritis Rheum. 2008
  PubMed ID: 18821667
   
  
• Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
  Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM
  Nat Genet. 2008
  PubMed ID: 18794853
   
  
• Homozygosity for DNASE2 single-nucleotide polymorphisms in the 5' regulatory region is associated with rheumatoid arthritis.
  Rossol M, Pierer M, Arnold S, Keyszer G, Burkhardt H, Baerwald C, Wagner U
  Ann Rheum Dis. 2008
  PubMed ID: 18812394
   
  
• Association of genetic profiles to Crohn's disease by linear combinations of single nucleotide polymorphisms.
  D'Addabbo A, Latiano A, Palmieri O, Creanza MT, Maglietta R, Annese V, Ancona N
  Artif Intell Med. 2008
  PubMed ID: 18804983
   
  
• The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
  Kariuki SN, Crow MK, Niewold TB
  Arthritis Rheum. 2008
  PubMed ID: 18759295
   
  
• The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22 gene) predisposes to autoimmune Addison's disease.
  Roycroft M, Fichna M, McDonald D, Owen K, Zurawek M, Gryczyńska M, Januszkiewicz-Lewandowska D, Fichna P, Cordell H, Donaldson P, Nowak J, Pearce S
  Clin Endocrinol (Oxf). 2008
  PubMed ID: 18710467
   
  
• [Association of polymorphism of proteintyrosine phosphatase nonreceptor-22 gene with AITD.]
  Yu ZY, Zhang JA, Maier HB, Wang Y, Xiao WX, Quan Y, Dong BN
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008
  PubMed ID: 18687223
   
  
• Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
  Julià A, Ballina J, Cañete JD, Balsa A, Tornero-Molina J, Naranjo A, Alperi-López M, Erra A, Pascual-Salcedo D, Barceló P, Camps J, Marsal S
  Arthritis Rheum. 2008
  PubMed ID: 18668548
   
  
• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
  Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ
  Nat Genet. 2008
  PubMed ID: 18587394
   
  
• Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis.
  Goëb V, Dieudé P, Daveau R, Thomas-L'otellier M, Jouen F, Hau F, Boumier P, Tron F, Gilbert D, Fardellone P, Cornélis F, Le Loët X, Vittecoq O
  Rheumatology (Oxford). 2008
  PubMed ID: 18535030
   
  
• PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis.
  Lefvert AK, Zhao Y, Ramanujam R, Yu S, Pirskanen R, Hammarström L
  J Neuroimmunol. 2008
  PubMed ID: 18533277
   
  
• The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis.
  Dieudé P, Guedj M, Wipff J, Avouac J, Hachulla E, Diot E, Granel B, Sibilia J, Cabane J, Meyer O, Mouthon L, Kahan A, Boileau C, Allanore Y
  Arthritis Rheum. 2008
  PubMed ID: 18576360
   
  
• The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations.
  Azarian M, Busson M, Rocha V, Ribaud P, Peffault de Latour R, Bleux H, Lepage V, Charron D, Toubert A, Socié G, Loiseau P
  Transplantation. 2008
  PubMed ID: 18580482
   
  
• Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population.
  Ichimura M, Kaku H, Fukutani T, Koga H, Mukai T, Miyake I, Yamada K, Koda Y, Hiromatsu Y
  Thyroid. 2008
  PubMed ID: 18578611
   
  
• Variants of CARD15, TNFA and PTPN22 and susceptibility to Crohn's disease in the Czech population: high frequency of the CARD15 1007fs.
  Hradsky O, Lenicek M, Dusatkova P, Bronsky J, Nevoral J, Valtrova V, Kotalova R, Szitanyi P, Petro R, Starzykova V, Bortlik M, Vitek L, Lukas M, Cinek O
  Tissue Antigens. 2008
  PubMed ID: 18489434
   
  
• Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides.
  Innala L, Kokkonen H, Eriksson C, Jidell E, Berglin E, Dahlqvst SR
  J Rheumatol. 2008
  PubMed ID: 18398946
   
  
• Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
  Costenbader KH, Chang SC, De Vivo I, Plenge R, Karlson EW
  Arthritis Res Ther. 2008
  PubMed ID: 18462498
   
  
• PTPN22 gene polymorphism in Takayasu's arteritis.
  Sahin N, Aksu K, Kamali S, Bicakcigil M, Ozbalkan Z, Fresko I, Ozer H, Akar S, Onat AM, Cobankara V, Kiraz S, Oztürk MA, Tunç E, Yücel E, Ates A, Keser G, Inanc M, Direskeneli H, Saruhan-Direskeneli G, RAED Vasculitis Study Group
  Rheumatology (Oxford). 2008
  PubMed ID: 18375974
   
  
• Polymorphisms in the PTPN22 region are associated with psoriasis of early onset.
  Smith RL, Warren RB, Eyre S, Ke X, Young HS, Allen M, Strachan D, McArdle W, Gittins MP, Barker JN, Griffiths CE, Worthington J
  Br J Dermatol. 2008
  PubMed ID: 18341666
   
  
• The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population.
  Laberge GS, Birlea SA, Fain PR, Spritz RA
  Pigment Cell Melanoma Res. 2008
  PubMed ID: 18426414
   
  
• Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis.
  Michou L, Teixeira VH, Pierlot C, Lasbleiz S, Bardin T, Dieudé P, Prum B, Cornélis F, Petit-Teixeira E
  Ann Rheum Dis. 2008
  PubMed ID: 17660221
   
  
• Association between PTPN22 and endometriosis.
  Ammendola M, Bottini N, Pietropolli A, Saccucci P, Gloria-Bottini F
  Fertil Steril. 2008
  PubMed ID: 17624340
   
  
• Association of RF and anti-CCP positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-TNF response in RA.
  Potter C, Hyrich KL, Tracey A, Lunt M, Plant D, Symmons DP, Thomson W, Worthington J, Emery P, Morgan AW, Wilson AG, Isaacs JD, Barton A
  Ann Rheum Dis. 2008
  PubMed ID: 18375541
   
  
• Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population.
  Laddha NC, Dwivedi M, Shajil EM, Prajapati H, Marfatia YS, Begum R
  J Dermatol Sci. 2008
  PubMed ID: 18037273
   
  
• Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease.
  Kisiel B, Bednarczuk T, Kostrzewa G, Kosińska J, Miśkiewicz P, Płazińska MT, Bar-Andziak E, Królicki L, Krajewski P, Płoski R
  Clin Endocrinol (Oxf). 2008
  PubMed ID: 17941906
   
  
• Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study.
  Karlson EW, Chibnik LB, Cui J, Plenge RM, Glass RJ, Maher NE, Parker A, Roubenoff R, Izmailova E, Coblyn JS, Weinblatt ME, Shadick NA
  Ann Rheum Dis. 2008
  PubMed ID: 17666451
   
  
• Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease.
  Skinningsrud B, Husebye ES, Gervin K, Løvås K, Blomhoff A, Wolff AB, Kemp EH, Egeland T, Undlien DE
  Eur J Hum Genet. 2008
  PubMed ID: 18301444
   
  
• Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis.
  Farragher TM, Goodson NJ, Naseem H, Silman AJ, Thomson W, Symmons D, Barton A
  Arthritis Rheum. 2008
  PubMed ID: 18240242
   
  
• Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
  International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD, Nath SK, Guthridge JM, Cobb BL, Mirel DB, Marion MC, Williams AH, Divers J, Wang W, Frank SG, Namjou B, Gabriel SB, Lee AT, Gregersen PK, Behrens TW, Taylor KE, Fernando M, Zidovetzki R, Gaffney PM, Edberg JC, Rioux JD, Ojwang JO, James JA, Merrill JT, Gilkeson GS, Seldin MF, Yin H, Baechler EC, Li QZ, Wakeland EK, Bruner GR, Kaufman KM, Kelly JA
  Nat Genet. 2008
  PubMed ID: 18204446
   
  
• Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis.
  Orozco G, Pascual-Salcedo D, López-Nevot MA, Cobo T, Cabezón A, Martín-Mola E, Balsa A, Martín J
  Rheumatology (Oxford). 2008
  PubMed ID: 18156150
   
  
• The R620W polymorphism in PTPN22 confers general susceptibility for the development of alopecia areata.
  Betz RC, König K, Flaquer A, Redler S, Eigelshoven S, Kortüm AK, Hanneken S, Hillmer A, Tüting T, Lambert J, De Weert J, Kruse R, Lutz G, Blaumeiser B, Nöthen MM
  Br J Dermatol. 2008
  PubMed ID: 18028494
   
  
• The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome.
  Naseem H, Thomson W, Silman A, Worthington J, Symmons D, Barton A
  Ann Rheum Dis. 2008
  PubMed ID: 17666450
   
  
• PTPN22 Is Genetically Associated with Risk of Generalized Vitiligo, but CTLA4 Is Not.
  Laberge GS, Bennett DC, Fain PR, Spritz RA
  J Invest Dermatol. 2008
  PubMed ID: 18200060
   
  
• Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
  Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
  PLoS ONE. 2008
  PubMed ID: 18818748
   
  
• Prevalence of common disease-associated variants in Asian Indians.
  Pemberton TJ, Mehta NU, Witonsky D, Di Rienzo A, Allayee H, Conti DV, Patel PI
  BMC Genet. 2008
  PubMed ID: 18248681
   
  
• Multiple pathways involved in the biosynthesis of anandamide.
  Liu J, Wang L, Harvey-White J, Huang BX, Kim HY, Luquet S, Palmiter RD, Krystal G, Rai R, Mahadevan A, Razdan RK, Kunos G
  Neuropharmacology. 2008
  PubMed ID: 17631919
   
  
• Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
  Yu X, Sun JP, He Y, Guo X, Liu S, Zhou B, Hudmon A, Zhang ZY
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 18056643
   
  
• Rheumatoid arthritis association at 6q23.
  Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, Donn R, Symmons D, Hider S, Bruce IN, Wellcome Trust Case Control Consortium, Wilson AG, Marinou I, Morgan A, Emery P, YEAR Consortium, Carter A, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Strachan D, Worthington J
  Nat Genet. 2007
  PubMed ID: 17982455
   
  
• Associations between the PTPN22 1858C->T polymorphism and radiographic joint destruction in patients with rheumatoid arthritis: results from a 10-year longitudinal study.
  Lie BA, Viken MK, Odegård S, van der Heijde D, Landewé R, Uhlig T, Kvien TK
  Ann Rheum Dis. 2007
  PubMed ID: 17472988
   
  
• PTPN22 gene polymorphism in Behçet's disease.
  Sahin N, Bicakcigil M, Atagunduz P, Direskeneli H, Saruhan-Direskeneli G
  Tissue Antigens. 2007
  PubMed ID: 17868256
   
  
• PTPN22 R620W polymorphism is not associated with pemphigus.
  Mejri K, Kallel-Sellami M, Petit-Teixeira E, Abida O, Mbarek H, Zitouni M, Ben Ayed M, Teixeira VH, Mokni M, Fazza B, Turki H, Tron F, Gilbert D, Masmoudi H, Cornelis F, Makni S
  Br J Dermatol. 2007
  PubMed ID: 17854359
   
  
• The association of the PTPN22 620W polymorphism with Behcet's disease.
  Baranathan V, Stanford MR, Vaughan RW, Kondeatis E, Graham E, Fortune F, Madanat W, Kanawati C, Ghabra M, Murray PI, Wallace GR
  Ann Rheum Dis. 2007
  PubMed ID: 17660222
   
  
• Association of p53 codon 72 polymorphism with endometriosis.
  Ammendola M, Gloria-Bottini F, Sesti F, Piccione E, Bottini E
  Fertil Steril. 2007
  PubMed ID: 17931634
   
  
• Gender-specific association of the PTPN22 C1858T polymorphism with achalasia.
  Santiago JL, Martínez A, Benito MS, Ruiz de León A, Mendoza JL, Fernández-Arquero M, Figueredo MA, de la Concha EG, Urcelay E
  Hum Immunol. 2007
  PubMed ID: 17961776
   
  
• Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes.
  Rieck M, Arechiga A, Onengut-Gumuscu S, Greenbaum C, Concannon P, Buckner JH
  J Immunol. 2007
  PubMed ID: 17878369
   
  
• Association of PTPN22 with rheumatoid arthritis among South Asians in the UK.
  Mastana S, Gilmour A, Ghelani A, Smith H, Samanta A
  J Rheumatol. 2007
  PubMed ID: 17696275
   
  
• Evaluating the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in inflammatory bowel disease: a meta-analysis.
  Latiano A, Palmieri O, Valvano MR, Bossa F, Latiano T, Corritore G, DeSanto E, Andriulli A, Annese V
  Inflamm Bowel Dis. 2007
  PubMed ID: 17600378
   
  
• Association of PTPN22 single nucleotide polymorphism with rheumatoid arthritis but not with allergic asthma.
  Majorczyk E, Jasek M, Płoski R, Wagner M, Kosior A, Pawlik A, Obojski A, Luszczek W, Nowak I, Wiśniewski A, Kuśnierczyk P
  Eur J Hum Genet. 2007
  PubMed ID: 17579671
   
  
• TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
  Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, Liew A, Khalili H, Chandrasekaran A, Davies LR, Li W, Tan AK, Bonnard C, Ong RT, Thalamuthu A, Pettersson S, Liu C, Tian C, Chen WV, Carulli JP, Beckman EM, Altshuler D, Alfredsson L, Criswell LA, Amos CI, Seldin MF, Kastner DL, Klareskog L, Gregersen PK
  N Engl J Med. 2007
  PubMed ID: 17804836
   
  
• Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to Henoch-Schönlein purpura.
  Orozco G, Miranda-Filloy JA, Martin J, Gonzalez-Gay MA
  Clin Exp Rheumatol. 2007
  PubMed ID: 18078626
   
  
• Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.
  Marinou I, Healy J, Mewar D, Moore DJ, Dickson MC, Binks MH, Montgomery DS, Walters K, Wilson AG
  Arthritis Rheum. 2007
  PubMed ID: 17665434
   
  
• Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
  Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG
  Nat Genet. 2007
  PubMed ID: 17554260
   
  
• Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients.
  Feitsma AL, Toes RE, Begovich AB, Chokkalingam AP, de Vries RR, Huizinga TW, van der Helm-van Mil AH
  Rheumatology (Oxford). 2007
  PubMed ID: 17341507
   
  
• IRF5 rs2004640-T allele, the new genetic factor for systemic lupus erythematosus, is not associated with rheumatoid arthritis.
  Garnier S, Dieudé P, Michou L, Barbet S, Tan A, Lasbleiz S, Bardin T, Prum B, Cornélis F
  Ann Rheum Dis. 2007
  PubMed ID: 17158136
   
  
• Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
  Kallberg H, Padyukov L, Plenge RM, Ronnelid J, Gregersen PK, van der Helm-van Mil AH, Toes RE, Huizinga TW, Klareskog L, Alfredsson L, Epidemiological Investigation of Rheumatoid Arthritis study group
  Am J Hum Genet. 2007
  PubMed ID: 17436241
   
  
• Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK.
  Hinks A, Eyre S, Barton A, Thomson W, Worthington J
  Ann Rheum Dis. 2007
  PubMed ID: 17170052
   
  
• The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.
  Wesoly J, Hu X, Thabet MM, Chang M, Uh H, Allaart CF, Toes RE, Houwing-Duistermaat JJ, Begovich AB, Huizinga TW
  Rheumatology (Oxford). 2007
  PubMed ID: 17135225
   
  
• PTPN22 620W allele is not associated with aplastic anemia.
  Graf SA, Calado RT, Young NS
  Am J Hematol. 2007
  PubMed ID: 17034023
   
  
• Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection.
  Robledo G, González CI, Morillo C, Martín J, González A
  Tissue Antigens. 2007
  PubMed ID: 17493151
   
  
• Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study.
  Pertovaara M, Raitala A, Juonala M, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT, Hurme M
  Clin Exp Immunol. 2007
  PubMed ID: 17223967
   
  
• Association of PTPN22 haplotypes with Graves' disease.
  Heward JM, Brand OJ, Barrett JC, Carr-Smith JD, Franklyn JA, Gough SC
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17148556
   
  
• Modeling the effect of PTPN22 in rheumatoid arthritis.
  Bourgey M, Perdry H, Clerget-Darpoux F
  BMC Proc. 2007
  PubMed ID: 18466535
   
  
• Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
  Yoo YJ, Gao G, Zhang K
  BMC Proc. 2007
  PubMed ID: 18466531
   
  
• Genome-wide linkage and association analysis of rheumatoid arthritis in a Canadian population.
  Wei Z, Li M
  BMC Proc. 2007
  PubMed ID: 18466515
   
  
• Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
  Mei L, Li X, Yang K, Cui J, Fang B, Guo X, Rotter JI
  BMC Proc. 2007
  PubMed ID: 18466513
   
  
• Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis.
  Gagnon F, Hajage D, Plancoulaine S, Tezenas du Montcel S
  BMC Proc. 2007
  PubMed ID: 18466483
   
  
• Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.
  Ding Y, Cong L, Ionita-Laza I, Lo SH, Zheng T
  BMC Proc. 2007
  PubMed ID: 18466472
   
  
• Meta-genetic association of rheumatoid arthritis and PTPN22 using PedGenie 2.1.
  Curtin K, Wong J, Allen-Brady K, Camp NJ
  BMC Proc. 2007
  PubMed ID: 18466461
   
  
• The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden.
  Kokkonen H, Johansson M, Innala L, Jidell E, Rantapää-Dahlqvist S
  Arthritis Res Ther. 2007
  PubMed ID: 17553139
   
  
• Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis.
  Steer S, Abkevich V, Gutin A, Cordell HJ, Gendall KL, Merriman ME, Rodger RA, Rowley KA, Chapman P, Gow P, Harrison AA, Highton J, Jones PB, O'Donnell J, Stamp L, Fitzgerald L, Iliev D, Kouzmine A, Tran T, Skolnick MH, Timms KM, Lanchbury JS, Merriman TR
  Genes Immun. 2007
  PubMed ID: 17159887
   
  
• The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis.
  Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK, Harley JB
  Rheumatology (Oxford). 2007
  PubMed ID: 16760194
   
  
• Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis.
  Gourh P, Tan FK, Assassi S, Ahn CW, McNearney TA, Fischbach M, Arnett FC, Mayes MD
  Arthritis Rheum. 2006
  PubMed ID: 17133608
   
  
• Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.
  Newman WG, Zhang Q, Liu X, Walker E, Ternan H, Owen J, Johnson B, Greer W, Mosher DP, Maksymowych WP, Bykerk VP, Keystone EC, Amos CI, Siminovitch KA
  Arthritis Rheum. 2006
  PubMed ID: 17133579
   
  
• Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population.
  Baca V, Velázquez-Cruz R, Salas-Martínez G, Espinosa-Rosales F, Saldaña-Alvarez Y, Orozco L
  Genes Immun. 2006
  PubMed ID: 17066073
   
  
• Multiplex family-based study in systemic lupus erythematosus: association between the R620W polymorphism of PTPN22 and the FcgammaRIIa (CD32A) R131 allele.
  Balada E, Villarreal-Tolchinsky J, Ordi-Ros J, Labrador M, Serrano-Acedo S, Martinez-Lostao L, Vilardell-Tarrés M
  Tissue Antigens. 2006
  PubMed ID: 17092257
   
  
• Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population.
  Ikari K, Momohara S, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N
  Rheumatology (Oxford). 2006
  PubMed ID: 16690758
   
  
• A biosynthetic pathway for anandamide.
  Liu J, Wang L, Harvey-White J, Osei-Hyiaman D, Razdan R, Gong Q, Chan AC, Zhou Z, Huang BX, Kim HY, Kunos G
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16938887
   
  
• Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis.
  Harbo HF, Ekstrøm PO, Lorentzen AR, Sundvold-Gjerstad V, Celius EG, Sawcer S, Spurkland A
  J Neuroimmunol. 2006
  PubMed ID: 16764945
   
  
• Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients.
  Harrison P, Pointon JJ, Farrar C, Brown MA, Wordsworth BP
  Rheumatology (Oxford). 2006
  PubMed ID: 16490755
   
  
• The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata.
  Kemp EH, McDonagh AJ, Wengraf DA, Messenger AG, Gawkrodger DJ, Cork MJ, Tazi-Ahnini R
  Hum Immunol. 2006
  PubMed ID: 16829308
   
  
• Evidence for susceptibility determinant(s) to psoriasis vulgaris in or near PTPN22 in German patients.
  Hüffmeier U, Steffens M, Burkhardt H, Lascorz J, Schürmeier-Horst F, Ständer M, Kelsch R, Baumann C, Küster W, Mössner R, Reich K, Wienker TF, Traupe H, Reis A
  J Med Genet. 2006
  PubMed ID: 16339849
   
  
• The DNA sequence and biological annotation of human chromosome 1.
  Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
  Nature. 2006
  PubMed ID: 16710414
   
  
• Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis.
  Balada E, Simeón-Aznar CP, Serrano-Acedo S, Martínez-Lostao L, Selva-O'Callaghan A, Fonollosa-Pla V, Vilardell-Tarrés M
  Clin Exp Rheumatol. 2006
  PubMed ID: 16870103
   
  
• The PTPN22 1858T variant is not associated with primary biliary cirrhosis.
  Milkiewicz P, Pache I, Buwaneswaran H, Liu X, Coltescu C, Heathcote EJ, Siminovitch KA
  Tissue Antigens. 2006
  PubMed ID: 16671954
   
  
• Identification of substrates of human protein-tyrosine phosphatase PTPN22.
  Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, Jeffery D, Mortara K, Sampang J, Williams SR, Buggy J, Clark JM
  J Biol Chem. 2006
  PubMed ID: 16461343
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Male restricted genetic association of variant R620W in PTPN22 with psoriatic arthritis.
  Hüffmeier U, Reis A, Steffens M, Lascorz J, Böhm B, Lohmann J, Wendler J, Traupe H, Küster W, Wienker TF, Burkhardt H
  J Invest Dermatol. 2006
  PubMed ID: 16456530
   
  
• Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis.
  Vandiedonck C, Capdevielle C, Giraud M, Krumeich S, Jais JP, Eymard B, Tranchant C, Gajdos P, Garchon HJ
  Ann Neurol. 2006
  PubMed ID: 16437561
   
  
• Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients.
  Pierer M, Kaltenhäuser S, Arnold S, Wahle M, Baerwald C, Häntzschel H, Wagner U
  Arthritis Res Ther. 2006
  PubMed ID: 16635271
   
  
• A functional PTPN22 polymorphism associated with several autoimmune diseases is not associated with IgA deficiency in the Spanish population.
  Núñez C, López-Mejías R, Martínez A, García-Rodríguez MC, Fernández-Arquero M, de la Concha EG, Urcelay E
  BMC Med Genet. 2006
  PubMed ID: 16539704
   
  
• Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study.
  Butt C, Peddle L, Greenwood C, Hamilton S, Gladman D, Rahman P
  Arthritis Res Ther. 2006
  PubMed ID: 16507123
   
  
• PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.
  Johansson M, Arlestig L, Hallmans G, Rantapää-Dahlqvist S
  Arthritis Res Ther. 2006
  PubMed ID: 16507117
   
  
• Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
  Burkhardt H, Hüffmeier U, Spriewald B, Böhm B, Rau R, Kallert S, Engström A, Holmdahl R, Reis A
  Arthritis Rheum. 2006
  PubMed ID: 16385499
   
  
• Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
  Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
  Genome Res. 2006
  PubMed ID: 16344560
   
  
• Genetic influence of PTPN22 R620W polymorphism in tuberculosis.
  Gomez LM, Anaya JM, Martin J
  Hum Immunol. 2005
  PubMed ID: 16690411
   
  
• Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
  Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD
  Am J Hum Genet. 2005
  PubMed ID: 16380915
   
  
• Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.
  Seldin MF, Shigeta R, Laiho K, Li H, Saila H, Savolainen A, Leirisalo-Repo M, Aho K, Tuomilehto-Wolf E, Kaarela K, Kauppi M, Alexander HC, Begovich AB, Tuomilehto J
  Genes Immun. 2005
  PubMed ID: 16107870
   
  
• The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1.
  Reddy MV, Johansson M, Sturfelt G, Jönsen A, Gunnarsson I, Svenungsson E, Rantapää-Dahlqvist S, Alarcón-Riquelme ME
  Genes Immun. 2005
  PubMed ID: 16052172
   
  
• HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?
  Brand O, Gough S, Heward J
  Expert Rev Mol Med. 2005
  PubMed ID: 16229750
   
  
• Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease.
  Kurylowicz A, Kula D, Ploski R, Skorka A, Jurecka-Lubieniecka B, Zebracka J, Steinhof-Radwanska K, Hasse-Lazar K, Hiromatsu Y, Jarzab B, Bednarczuk T
  Thyroid. 2005
  PubMed ID: 16279844
   
  
• The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese.
  Ban Y, Tozaki T, Taniyama M, Tomita M, Ban Y
  Thyroid. 2005
  PubMed ID: 16279843
   
  
• The functional genetic variation in the PTPN22 gene has a negligible effect on the susceptibility to develop inflammatory bowel disease.
  Martín MC, Oliver J, Urcelay E, Orozco G, Gómez-Garcia M, López-Nevot MA, Piñero A, Brieva JA, de la Concha EG, Nieto A, Martín J
  Tissue Antigens. 2005
  PubMed ID: 16185327
   
  
• PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.
  Carlton VE, Hu X, Chokkalingam AP, Schrodi SJ, Brandon R, Alexander HC, Chang M, Catanese JJ, Leong DU, Ardlie KG, Kastner DL, Seldin MF, Criswell LA, Gregersen PK, Beasley E, Thomson G, Amos CI, Begovich AB
  Am J Hum Genet. 2005
  PubMed ID: 16175503
   
  
• A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease.
  Wagenleiter SE, Klein W, Griga T, Schmiegel W, Epplen JT, Jagiello P
  Int J Immunogenet. 2005
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• Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.
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