XRCC6

Summary Top Help

Gene Description:

X-ray repair complementing defective repair in Chinese hamster cells 6

Synonyms:

Kup70, Ku70, ML8, CTC75, TLAA, Xrcc6, G22p1, KU70, 70kDa, G22P1, CTCBF, XRCC6

Orthologs:

Human XRCC6 (protein-coding), Mouse Xrcc6 (protein-coding), Rat Xrcc6 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm34	Rat	chr7:96517746..137757704	41.24	447

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr22:42017123..42060052 (42.93 kb) View in Genome Browser

(Mouse) NCBIM37 - chr15:81818265..81870515 (52.25 kb) View in Genome Browser

(Rat) RGSC3.4 - chr7:120401944..120422923 (20.98 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for XRCC6:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for XRCC6:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 1

Reactome: 5

NCI-Nature Pathway Interaction Database: 5

Gene Ontology: 37

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 335

Ku regulates signaling to DNA damage response pathways through the Ku70 von Willebrand A domain.
Fell VL, Schild-Poulter C
Mol Cell Biol. 2012
PubMed ID: 22037767
Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism.
Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA
Biochem Biophys Res Commun. 2011
PubMed ID: 22079093
Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons.
Mandraju R, Chekuri A, Bhaskar C, Duning K, Kremerskothen J, Kondapi AK
Arch Biochem Biophys. 2011
PubMed ID: 22019940
Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS
J Proteomics. 2011
PubMed ID: 22178446
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM
Chem Biol. 2011
PubMed ID: 22118674
Accumulation of Ku70 at DNA double-strand breaks in living epithelial cells.
Koike M, Yutoku Y, Koike A
Exp Cell Res. 2011
PubMed ID: 21820429
KARP-1 works as a heterodimer with Ku70, but the function of KARP-1 cannot perfectly replace that of Ku80 in DSB repair.
Koike M, Yutoku Y, Koike A
Exp Cell Res. 2011
PubMed ID: 21756904
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21825151
Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics.
Jia H, Liu C, Ge F, Xiao C, Lu C, Wang T, He Q
Biomed Environ Sci. 2011
PubMed ID: 22108332
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Host protein Ku70 binds and protects HIV-1 integrase from proteasomal degradation and is required for HIV replication.
Zheng Y, Ao Z, Wang B, Jayappa KD, Yao X
J Biol Chem. 2011
PubMed ID: 21454661
Establishment of ku70-deficient lung epithelial cell lines and their hypersensitivity to low-dose x-irradiation.
Koike M, Yutoku Y, Koike A
J Vet Med Sci. 2011
PubMed ID: 21160137
Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.
Zhang X, Brann TW, Zhou M, Yang J, Oguariri RM, Lidie KB, Imamichi H, Huang DW, Lempicki RA, Baseler MW, Veenstra TD, Young HA, Lane HC, Imamichi T
J Immunol. 2011
PubMed ID: 21398614
Role of the XRCC5/XRCC6 dimer in carcinogenesis and pharmacogenomics.
Bau DT, Tsai CW, Wu CN
Pharmacogenomics. 2011
PubMed ID: 21521024
Depletion of Ku70/80 reduces the levels of extrachromosomal telomeric circles and inhibits proliferation of ALT cells.
Li B, Reddy S, Comai L
Aging (Albany NY). 2011
PubMed ID: 21512205
Genetic polymorphisms in DNA double-strand break repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma.
Li R, Yang Y, An Y, Zhou Y, Liu Y, Yu Q, Lu D, Wang H, Jin L, Zhou W, Qian J, Shugart YY
Carcinogenesis. 2011
PubMed ID: 21304054
Ku70 and Rad51 vary in their importance for the repair of doxorubicin- versus etoposide-induced DNA damage.
Schonn I, Hennesen J, Dartsch DC
Apoptosis. 2011
PubMed ID: 21107697
An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 14-3-3 proteins.
Hoek M, Myers MP, Stillman B
J Biol Chem. 2011
PubMed ID: 21209461
Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF.
Yano K, Morotomi-Yano K, Lee KJ, Chen DJ
FEBS Lett. 2011
PubMed ID: 21349273
Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair.
Paddock MN, Bauman AT, Higdon R, Kolker E, Takeda S, Scharenberg AM
DNA Repair (Amst). 2011
PubMed ID: 21256093
Is there any association between TACSTD2, KIAA1253, Ku70 and mutant KRAS gene expression and clinical-pathological features of colorectal cancer?
Ghezzi TL, Brum IS, Biolchi V, Garicochea B, Fillmann LS, Corleta OC
Exp Oncol. 2011
PubMed ID: 21423092
The DNA repair complex Ku70/86 modulates Apaf1 expression upon DNA damage.
De Zio D, Bordi M, Tino E, Lanzuolo C, Ferraro E, Mora E, Ciccosanti F, Fimia GM, Orlando V, Cecconi F
Cell Death Differ. 2011
PubMed ID: 20966962
Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix.
Choi HR, Cho KA, Kang HT, Lee JB, Kaeberlein M, Suh Y, Chung IK, Park SC
Aging Cell. 2011
PubMed ID: 21108727
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.
Fnu S, Williamson EA, De Haro LP, Brenneman M, Wray J, Shaheen M, Radhakrishnan K, Lee SH, Nickoloff JA, Hromas R
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21187428
Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan.
Yang MD, Wang HC, Chang WS, Tsai CW, Bau DT
BMC Cancer. 2011
PubMed ID: 21575261
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
The ACF1 complex is required for DNA double-strand break repair in human cells.
Lan L, Ui A, Nakajima S, Hatakeyama K, Hoshi M, Watanabe R, Janicki SM, Ogiwara H, Kohno T, Kanno S, Yasui A
Mol Cell. 2010
PubMed ID: 21172662
Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining.
Velma V, Carrero ZI, Cosman AM, Hebert MD
FEBS Lett. 2010
PubMed ID: 21070772
Low expression of Ku70/80, but high expression of DNA-PKcs, predict good response to radiotherapy in early breast cancer.
Söderlund Leifler K, Queseth S, Fornander T, Askmalm MS
Int J Oncol. 2010
PubMed ID: 21042724
Identification of differential protein interactors of lamin A and progerin.
Kubben N, Voncken JW, Demmers J, Calis C, van Almen G, Pinto Y, Misteli T
Nucleus. 2010
PubMed ID: 21327095
The DNA damage repair protein Ku70 interacts with FOXO4 to coordinate a conserved cellular stress response.
Brenkman AB, van den Broek NJ, de Keizer PL, van Gent DC, Burgering BM
FASEB J. 2010
PubMed ID: 20570964
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert MR, Aldape KD, Xing J, Wu X, Wei Q, Bondy ML
Carcinogenesis. 2010
PubMed ID: 20610542
Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.
Hu H, Zhang Y, Zou M, Yang S, Liang XQ
J Cancer Res Clin Oncol. 2010
PubMed ID: 20127252
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium
Am J Epidemiol. 2010
PubMed ID: 20522537
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway.
Pace P, Mosedale G, Hodskinson MR, Rosado IV, Sivasubramaniam M, Patel KJ
Science. 2010
PubMed ID: 20538911
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.
Liu H, Herrmann CH, Chiang K, Sung TL, Moon SH, Donehower LA, Rice AP
Biochem Biophys Res Commun. 2010
PubMed ID: 20493174
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A
Genes Dev. 2010
PubMed ID: 20504901
DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.
Takedachi A, Saijo M, Tanaka K
Mol Cell Biol. 2010
PubMed ID: 20368362
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.
Wang H, Zhang X, Wang P, Yu X, Essers J, Chen D, Kanaar R, Takeda S, Wang Y
Nucleic Acids Res. 2010
PubMed ID: 20150414
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J
Breast Cancer Res Treat. 2010
PubMed ID: 20496165
Radiation-induced survivin nuclear accumulation is linked to DNA damage repair.
Capalbo G, Dittmann K, Weiss C, Reichert S, Hausmann E, Rödel C, Rödel F
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20394854
Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity.
Kanungo J
Mol Cell Biochem. 2010
PubMed ID: 20047046
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.
Roberts SA, Strande N, Burkhalter MD, Strom C, Havener JM, Hasty P, Ramsden DA
Nature. 2010
PubMed ID: 20383123
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair.
Lee HS, Park JH, Kim SJ, Kwon SJ, Kwon J
EMBO J. 2010
PubMed ID: 20224553
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
Distribution, cellular localization, and therapeutic potential of the tumor-associated antigen Ku70/80 in glioblastoma multiforme.
Persson O, Salford LG, Fransson J, Widegren B, Borrebaeck CA, Holmqvist B
J Neurooncol. 2010
PubMed ID: 19809793
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal.
Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T
Science. 2010
PubMed ID: 20339076
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133803
Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW
J Exp Med. 2010
PubMed ID: 20142431
Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity.
Vandersickel V, Depuydt J, Van Bockstaele B, Perletti G, Philippe J, Thierens H, Vral A
J Radiat Res (Tokyo). 2010
PubMed ID: 21116096
Ku70 acetylation in neuroblastoma pathogenesis and therapy.
Castle V, Kwok R, Opipari A, Subramanian C
Trans Am Clin Climatol Assoc. 2010
PubMed ID: 20697560
Analysis of the polymorphisms in non-homologous DNA end joining (NHEJ) gene Ku70 and Ligase IV in sporadic breast cancer in women.
Sobczuk A, Smolarz B, Romanowicz H, Zadrozny M, Baszczyński J, Westfal B, Pertyński T
Pol J Pathol. 2010
PubMed ID: 20496270
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
Ohno M, Kunimoto M, Nishizuka M, Osada S, Imagawa M
Biochem Biophys Res Commun. 2009
PubMed ID: 19833092
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Ku70 regulates Bax-mediated pathogenesis in laminin-alpha2-deficient human muscle cells and mouse models of congenital muscular dystrophy.
Vishnudas VK, Miller JB
Hum Mol Genet. 2009
PubMed ID: 19692349
The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation.
Liu J, Naegele JR, Lin SL
Brain Res. 2009
PubMed ID: 19664609
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.
Wang Q, Gao F, Wang T, Flagg T, Deng X
Neoplasia. 2009
PubMed ID: 19794960
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ
Science. 2009
PubMed ID: 19661379
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Beskow C, Skikuniene J, Holgersson A, Nilsson B, Lewensohn R, Kanter L, Viktorsson K
Br J Cancer. 2009
PubMed ID: 19672258
Hepatitis C virus-core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes.
Saitou K, Mizumoto K, Nishimura T, Kai C, Tsukiyama-Kohara K
Virus Res. 2009
PubMed ID: 19467273
A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure.
Willems P, De Ruyck K, Van den Broecke R, Makar A, Perletti G, Thierens H, Vral A
J Cancer Res Clin Oncol. 2009
PubMed ID: 19219618
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666485
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Protective effect of lycopene on oxidative stress-induced cell death of pancreatic acinar cells.
Seo JY, Masamune A, Shimosegawa T, Kim H
Ann N Y Acad Sci. 2009
PubMed ID: 19723106
Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes: a multiple genotype-phenotype study.
Tseng RC, Hsieh FJ, Shih CM, Hsu HS, Chen CY, Wang YC
Cancer. 2009
PubMed ID: 19408343
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization.
Gama V, Gomez JA, Mayo LD, Jackson MW, Danielpour D, Song K, Haas AL, Laughlin MJ, Matsuyama S
Cell Death Differ. 2009
PubMed ID: 19247369
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
Mol Cell. 2009
PubMed ID: 19394292
p53 acetylation is crucial for its transcription-independent proapoptotic functions.
Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, Monteiro A, Liu X, Hung MC, Wang HG
J Biol Chem. 2009
PubMed ID: 19265193
Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells.
Li H, Choi YJ, Hanes MA, Marple T, Vogel H, Hasty P
Oncogene. 2009
PubMed ID: 19330025
Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner.
Chan YG, Cardwell MM, Hermanas TM, Uchiyama T, Martinez JJ
Cell Microbiol. 2009
PubMed ID: 19134120
Cerebral expression of DNA repair protein, Ku70, and its association with cell proliferation following cerebral hypoxia-ischemia in neonatal rats.
Meng S, Lin L, Lama S, Qiao M, Tuor UI
Int J Dev Neurosci. 2009
PubMed ID: 19121380
Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.
Hossain MB, Ji P, Anish R, Jacobson RH, Takada S
J Biol Chem. 2009
PubMed ID: 19181665
A role of DNA-PK for the metabolic gene regulation in response to insulin.
Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS
Cell. 2009
PubMed ID: 19303849
MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP
J Exp Med. 2009
PubMed ID: 19221393
Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes.
Werbrouck J, De Ruyck K, Duprez F, Veldeman L, Claes K, Van Eijkeren M, Boterberg T, Willems P, Vral A, De Neve W, Thierens H
Int J Radiat Oncol Biol Phys. 2009
PubMed ID: 19251090
Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.
Pucci S, Paola M, Fabiola S, David BA, Luigi SG
Cell Cycle. 2009
PubMed ID: 19177010
Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.
Linkermann A, Gelhaus C, Lettau M, Qian J, Kabelitz D, Janssen O
Biochim Biophys Acta. 2009
PubMed ID: 19041431
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.
Vineis P, Manuguerra M, Kavvoura FK, Guarrera S, Allione A, Rosa F, Di Gregorio A, Polidoro S, Saletta F, Ioannidis JP, Matullo G
J Natl Cancer Inst. 2009
PubMed ID: 19116388
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF
Aging (Albany NY). 2009
PubMed ID: 20157594
Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.
Nolens G, Pignon JC, Koopmansch B, Elmoualij B, Zorzi W, De Pauw E, Winkler R
Breast Cancer Res. 2009
PubMed ID: 19906305
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
Gurley KE, Moser R, Gu Y, Hasty P, Kemp CJ
EMBO Rep. 2009
PubMed ID: 19057578
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes.
Bredemeyer AL, Helmink BA, Innes CL, Calderon B, McGinnis LM, Mahowald GK, Gapud EJ, Walker LM, Collins JB, Weaver BK, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP
Nature. 2008
PubMed ID: 18849970
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.
Kim E, Li K, Lieu C, Tong S, Kawai S, Fukutomi T, Zhou Y, Wands J, Li J
J Hepatol. 2008
PubMed ID: 18809223
Ku antigen interacts with abasic sites.
Ilina ES, Lavrik OI, Khodyreva SN
Biochim Biophys Acta. 2008
PubMed ID: 18757043
Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.
Lara PC, Lloret M, Clavo B, Apolinario RM, Bordón E, Rey A, Falcón O, Alonso AR, Belka C
Radiother Oncol. 2008
PubMed ID: 18706726
Single-nucleotide polymorphisms in DNA double-strand break repair genes: association with head and neck cancer and interaction with tobacco use and alcohol consumption.
Werbrouck J, De Ruyck K, Duprez F, Van Eijkeren M, Rietzschel E, Bekaert S, Vral A, De Neve W, Thierens H
Mutat Res. 2008
PubMed ID: 18768166
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP
Mol Cell Biol. 2008
PubMed ID: 18710944
No overt nucleosome eviction at deprotected telomeres.
Wu P, de Lange T
Mol Cell Biol. 2008
PubMed ID: 18625717
Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer.
Pavón MA, Parreño M, León X, Sancho FJ, Céspedes MV, Casanova I, Lopez-Pousa A, Mangues MA, Quer M, Barnadas A, Mangues R
Int J Cancer. 2008
PubMed ID: 18546291
Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues.
Uehara Y, Ikehata H, Komura J, Ito A, Ogata M, Itoh T, Hirayama R, Furusawa Y, Ando K, Paunesku T, Woloschak GE, Komatsu K, Matsuura S, Ikura T, Kamiya K, Ono T
Radiat Res. 2008
PubMed ID: 18666816
Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity.
Shin A, Lee KM, Ahn B, Park CG, Noh SK, Park DY, Ahn SH, Yoo KY, Kang D
Asian Pac J Cancer Prev. 2008
PubMed ID: 18990028
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair.
Bennardo N, Cheng A, Huang N, Stark JM
PLoS Genet. 2008
PubMed ID: 18584027
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Teoh NC, Dan YY, Swisshelm K, Lehman S, Wright JH, Haque J, Gu Y, Fausto N
Hepatology. 2008
PubMed ID: 18506893
Prognostic importance of DNA repair gene polymorphisms of XRCC1 Arg399Gln and XPD Lys751Gln in lung cancer patients from India.
Sreeja L, Syamala VS, Syamala V, Hariharan S, Raveendran PB, Vijayalekshmi RV, Madhavan J, Ankathil R
J Cancer Res Clin Oncol. 2008
PubMed ID: 17952468
Oral cancer and genetic polymorphism of DNA double strand break gene Ku70 in Taiwan.
Bau DT, Tseng HC, Wang CH, Chiu CF, Hua CH, Wu CN, Liang SY, Wang CL, Tsai CW, Tsai MH
Oral Oncol. 2008
PubMed ID: 18487076
A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A
Nucleic Acids Res. 2008
PubMed ID: 18385154
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.
Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W
Mol Cell. 2008
PubMed ID: 18406329
Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation.
Amsel AD, Rathaus M, Kronman N, Cohen HY
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18362350
Influence of Multiple Genetic Polymorphisms on Genitourinary Morbidity After Carbon Ion Radiotherapy for Prostate Cancer.
Suga T, Iwakawa M, Tsuji H, Ishikawa H, Oda E, Noda S, Otsuka Y, Ishikawa A, Ishikawa KI, Shimazaki J, Mizoe JE, Tsujii H, Imai T
Int J Radiat Oncol Biol Phys. 2008
PubMed ID: 18374504
Accumulation of Ku80 proteins at DNA double-strand breaks in living cells.
Koike M, Koike A
Exp Cell Res. 2008
PubMed ID: 18164703
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.
Pabla N, Huang S, Mi QS, Daniel R, Dong Z
J Biol Chem. 2008
PubMed ID: 18162465
Transcriptome sequencing of malignant pleural mesothelioma tumors.
Sugarbaker DJ, Richards WG, Gordon GJ, Dong L, De Rienzo A, Maulik G, Glickman JN, Chirieac LR, Hartman ML, Taillon BE, Du L, Bouffard P, Kingsmore SF, Miller NA, Farmer AD, Jensen RV, Gullans SR, Bueno R
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18303113
Association of autoantibodies with Ku and DNA repair proteins in connective tissue diseases.
Schild-Poulter C, Su A, Shih A, Kelly OP, Fritzler MJ, Goldstein R, Haché RJ
Rheumatology (Oxford). 2008
PubMed ID: 18208821
Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity.
Willems P, Claes K, Baeyens A, Vandersickel V, Werbrouck J, De Ruyck K, Poppe B, Van den Broecke R, Makar A, Marras E, Perletti G, Thierens H, Vral A
Genes Chromosomes Cancer. 2008
PubMed ID: 18000863
NF-kappaB p65 regulates nuclear translocation of Ku70 via degradation of heat shock cognate protein 70 in pancreatic acinar AR42J cells.
Lim JW, Kim KH, Kim H
Int J Biochem Cell Biol. 2008
PubMed ID: 18378183
hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo.
Mateuca RA, Roelants M, Iarmarcovai G, Aka PV, Godderis L, Tremp A, Bonassi S, Fenech M, Bergé-Lefranc JL, Kirsch-Volders M
Mutagenesis. 2008
PubMed ID: 17971348
Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.
Someya M, Sakata K, Matsumoto Y, Satoh M, Narimatsu H, Hareyama M
Oncol Rep. 2007
PubMed ID: 17982634
Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.
Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S
Cell Death Differ. 2007
PubMed ID: 17885668
Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer.
Li H, Vogel H, Holcomb VB, Gu Y, Hasty P
Mol Cell Biol. 2007
PubMed ID: 17875923
Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis.
Com E, Lagadec C, Page A, El Yazidi-Belkoura I, Slomianny C, Spencer A, Hammache D, Rudkin BB, Hondermarck H
Mol Cell Proteomics. 2007
PubMed ID: 17617666
Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells.
Prall WC, Czibere A, Jäger M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M
Mech Ageing Dev. 2007
PubMed ID: 17714764
Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma.
Liu Y, Zhang H, Zhou K, Chen L, Xu Z, Zhong Y, Liu H, Li R, Shugart YY, Wei Q, Jin L, Huang F, Lu D, Zhou L
Carcinogenesis. 2007
PubMed ID: 17389609
Bin1 interacts with and restrains the DNA end-binding protein complex Ku.
Ramalingam A, Farmer GE, Stamato TD, Prendergast GC
Cell Cycle. 2007
PubMed ID: 17671430
DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage.
Schild-Poulter C, Shih A, Tantin D, Yarymowich NC, Soubeyrand S, Sharp PA, Haché RJ
Oncogene. 2007
PubMed ID: 17213819
Transport of the leaderless protein Ku on the cell surface of activated monocytes regulates their migratory abilities.
Paupert J, Dauvillier S, Salles B, Muller C
EMBO Rep. 2007
PubMed ID: 17496833
Arsenite-induced alterations in Ku70-deficient cells: a model to study genotoxic effects.
Liu QZ, Jiang GF, He Y, Wang XR, Zhou JW, Zhuang ZX
J Toxicol Environ Health A. 2007
PubMed ID: 17479409
Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis.
Mazumder S, Plesca D, Kinter M, Almasan A
Mol Cell Biol. 2007
PubMed ID: 17325036
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Wang X, Liu L, Montagna C, Ried T, Deng CX
Cell Death Differ. 2007
PubMed ID: 17318223
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.
Tomimatsu N, Tahimic CG, Otsuki A, Burma S, Fukuhara A, Sato K, Shiota G, Oshimura M, Chen DJ, Kurimasa A
J Biol Chem. 2007
PubMed ID: 17272272
Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells.
Tu LC, Yan X, Hood L, Lin B
Mol Cell Proteomics. 2007
PubMed ID: 17220478
Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.
Jeyakumar M, Liu XF, Erdjument-Bromage H, Tempst P, Bagchi MK
J Biol Chem. 2007
PubMed ID: 17242407
SIRT1 promotes DNA repair activity and deacetylation of Ku70.
Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH
Exp Mol Med. 2007
PubMed ID: 17334224
A role for the HOXB7 homeodomain protein in DNA repair.
Rubin E, Wu X, Zhu T, Cheung JC, Chen H, Lorincz A, Pandita RK, Sharma GG, Ha HC, Gasson J, Hanakahi LA, Pandita TK, Sukumar S
Cancer Res. 2007
PubMed ID: 17308091
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura Y, Imai K, Hirohashi S, Yamada T
Cancer Res. 2007
PubMed ID: 17283121
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
Pterygium and genetic polymorphism of DNA double strand break repair gene Ku70.
Tsai YY, Bau DT, Chiang CC, Cheng YW, Tseng SH, Tsai FJ
Mol Vis. 2007
PubMed ID: 17768380
Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells.
Shi L, Qiu D, Zhao G, Corthesy B, Lees-Miller S, Reeves WH, Kao PN
Nucleic Acids Res. 2007
PubMed ID: 17389650
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs.
Rivera-Calzada A, Spagnolo L, Pearl LH, Llorca O
EMBO Rep. 2007
PubMed ID: 17159921
Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence.
Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
Exp Mol Med. 2006
PubMed ID: 17202845
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4.
Mari PO, Florea BI, Persengiev SP, Verkaik NS, Brüggenwirth HT, Modesti M, Giglia-Mari G, Bezstarosti K, Demmers JA, Luider TM, Houtsmuller AB, van Gent DC
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17124166
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.
Drouet J, Frit P, Delteil C, de Villartay JP, Salles B, Calsou P
J Biol Chem. 2006
PubMed ID: 16857680
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination.
Celli GB, Denchi EL, de Lange T
Nat Cell Biol. 2006
PubMed ID: 16845382
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.
Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG
Science. 2006
PubMed ID: 16794079
Effect of Ku proteins on IRES-mediated translation.
Silvera D, Koloteva-Levine N, Burma S, Elroy-Stein O
Biol Cell. 2006
PubMed ID: 16448389
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.
Spagnolo L, Rivera-Calzada A, Pearl LH, Llorca O
Mol Cell. 2006
PubMed ID: 16713581
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.
Riedel CG, Katis VL, Katou Y, Mori S, Itoh T, Helmhart W, Gálová M, Petronczki M, Gregan J, Cetin B, Mudrak I, Ogris E, Mechtler K, Pelletier L, Buchholz F, Shirahige K, Nasmyth K
Nature. 2006
PubMed ID: 16541024
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.
Zhu P, Zhang D, Chowdhury D, Martinvalet D, Keefe D, Shi L, Lieberman J
EMBO Rep. 2006
PubMed ID: 16440001
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.
Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T
EMBO J. 2006
PubMed ID: 16407974
Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression.
Grote J, König S, Ackermann D, Sopalla C, Benedyk M, Los M, Kerkhoff C
BMC Mol Biol. 2006
PubMed ID: 17187679
Recognition of cytosolic DNA activates an IRF3-dependent innate immune response.
Stetson DB, Medzhitov R
Immunity. 2006
PubMed ID: 16413926
Alternative pathways for the repair of RAG-induced DNA breaks.
Weinstock DM, Jasin M
Mol Cell Biol. 2006
PubMed ID: 16354685
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ
J Biol Chem. 2005
PubMed ID: 16159877
Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii.
Martinez JJ, Seveau S, Veiga E, Matsuyama S, Cossart P
Cell. 2005
PubMed ID: 16360032
Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
Niture SK, Doneanu CE, Velu CS, Bailey NI, Srivenugopal KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16226712
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.
Jung SY, Malovannaya A, Wei J, O'Malley BW, Qin J
Mol Endocrinol. 2005
PubMed ID: 16051665
Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.
Lee JC, Lee CH, Su CL, Huang CW, Liu HS, Lin CN, Won SJ
Carcinogenesis. 2005
PubMed ID: 15905197
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.
Gevaert K, Staes A, Van Damme J, De Groot S, Hugelier K, Demol H, Martens L, Goethals M, Vandekerckhove J
Proteomics. 2005
PubMed ID: 16097034
The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells.
Griffin C, Waard H, Deans B, Thacker J
DNA Repair (Amst). 2005
PubMed ID: 15979950
WW domains provide a platform for the assembly of multiprotein networks.
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T
Mol Cell Biol. 2005
PubMed ID: 16055720
Decreased origin usage and initiation of DNA replication in haploinsufficient HCT116 Ku80+/- cells.
Sibani S, Price GB, Zannis-Hadjopoulos M
J Cell Sci. 2005
PubMed ID: 16014376
Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk.
Lee KM, Choi JY, Kang C, Kang CP, Park SK, Cho H, Cho DY, Yoo KY, Noh DY, Ahn SH, Park CG, Wei Q, Kang D
Clin Cancer Res. 2005
PubMed ID: 15958648
Oxidative damage and defective DNA repair is linked to apoptosis of migrating neurons and progenitors during cerebral cortex development in Ku70-deficient mice.
Narasimhaiah R, Tuchman A, Lin SL, Naegele JR
Cereb Cortex. 2005
PubMed ID: 15342428
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase.
Feki A, Jefford CE, Berardi P, Wu JY, Cartier L, Krause KH, Irminger-Finger I
Oncogene. 2005
PubMed ID: 15782130
Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.
Katz DJ, Beer MA, Levorse JM, Tilghman SM
Mol Cell Biol. 2005
PubMed ID: 15870260
Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.
Ayene IS, Ford LP, Koch CJ
Mol Cancer Ther. 2005
PubMed ID: 15827325
Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
Mayeur GL, Kung WJ, Martinez A, Izumiya C, Chen DJ, Kung HJ
J Biol Chem. 2005
PubMed ID: 15640154
Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.
Mischo HE, Hemmerich P, Grosse F, Zhang S
J Biol Chem. 2005
PubMed ID: 15613478
DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.
Drouet J, Delteil C, Lefrançois J, Concannon P, Salles B, Calsou P
J Biol Chem. 2005
PubMed ID: 15520013
DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.
Dragoi AM, Fu X, Ivanov S, Zhang P, Sheng L, Wu D, Li GC, Chu WM
EMBO J. 2005
PubMed ID: 15678105
Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.
Wang Q, Zhang Z, Blackwell K, Carmichael GG
Curr Biol. 2005
PubMed ID: 15723802
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Retroviral DNA integration--mechanism and consequences.
Lewinski MK, Bushman FD
Adv Genet. 2005
PubMed ID: 16291214
Human Ku70/80 interacts directly with hTR, the RNA component of human telomerase.
Ting NS, Yu Y, Pohorelic B, Lees-Miller SP, Beattie TL
Nucleic Acids Res. 2005
PubMed ID: 15824061
Tagging genes with cassette-exchange sites.
Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R
Nucleic Acids Res. 2005
PubMed ID: 15741177
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Genetic steps of mammalian homologous repair with distinct mutagenic consequences.
Stark JM, Pierce AJ, Oh J, Pastink A, Jasin M
Mol Cell Biol. 2004
PubMed ID: 15485900
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression.
Sucharov CC, Helmke SM, Langer SJ, Perryman MB, Bristow M, Leinwand L
Mol Cell Biol. 2004
PubMed ID: 15367688
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE
Mol Cell. 2004
PubMed ID: 15383276
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.
Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C
J Biol Chem. 2004
PubMed ID: 15159402
Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule.
Sawchuk DJ, Mansilla-Soto J, Alarcon C, Singha NC, Langen H, Bianchi ME, Lees-Miller SP, Nussenzweig MC, Cortes P
J Biol Chem. 2004
PubMed ID: 15123719
The human Rap1 protein complex and modulation of telomere length.
O'Connor MS, Safari A, Liu D, Qin J, Songyang Z
J Biol Chem. 2004
PubMed ID: 15100233
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
A human cellular protein activity (OF-1), which binds herpes simplex virus type 1 origin, contains the Ku70/Ku80 heterodimer.
Murata LB, Dodson MS, Hall JD
J Virol. 2004
PubMed ID: 15220460
Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.
Wang H, Fang R, Cho JY, Libermann TA, Oettgen P
J Biol Chem. 2004
PubMed ID: 15075319
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1.
Li B, Navarro S, Kasahara N, Comai L
J Biol Chem. 2004
PubMed ID: 14734561
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
The Membrane-associated form of the DNA repair protein Ku is involved in cell adhesion to fibronectin.
Monferran S, Muller C, Mourey L, Frit P, Salles B
J Mol Biol. 2004
PubMed ID: 15019772
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA
Mol Cell. 2004
PubMed ID: 15023334
Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47.
Dreveny I, Kondo H, Uchiyama K, Shaw A, Zhang X, Freemont PS
EMBO J. 2004
PubMed ID: 14988733
Application of new in situ hybridization probes for Ku70 and Ku80 in tissue microarrays of paraffin-embedded malignant melanomas: correlation with immunohistochemical analysis.
Korabiowska M, Bauer H, Quentin T, Stachura J, Cordon-Cardo C, Brinck U
Hum Pathol. 2004
PubMed ID: 14991539
Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.
Hammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH
Endocrinology. 2004
PubMed ID: 14576192
The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells.
Lim JW, Kim H, Kim KH
J Biol Chem. 2004
PubMed ID: 14570916
A genome annotation-driven approach to cloning the human ORFeome.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I
Genome Biol. 2004
PubMed ID: 15461802
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.
Libby BJ, Reinholdt LG, Schimenti JC
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14668445
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.
Park EJ, Chan DW, Park JH, Oettinger MA, Kwon J
Nucleic Acids Res. 2003
PubMed ID: 14627815
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Oxidative stress induces nuclear loss of DNA repair proteins Ku70 and Ku80 and apoptosis in pancreatic acinar AR42J cells.
Song JY, Lim JW, Kim H, Morio T, Kim KH
J Biol Chem. 2003
PubMed ID: 12867423
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex.
Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y
J Biol Chem. 2003
PubMed ID: 12756247
Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair.
Leppard JB, Dong Z, Mackey ZB, Tomkinson AE
Mol Cell Biol. 2003
PubMed ID: 12897160
The role of DNA breaks in genomic instability and tumorigenesis.
Mills KD, Ferguson DO, Alt FW
Immunol Rev. 2003
PubMed ID: 12846809
Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements.
Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P
J Biol Chem. 2003
PubMed ID: 12672812
Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.
Fu YP, Yu JC, Cheng TC, Lou MA, Hsu GC, Wu CY, Chen ST, Wu HS, Wu PE, Shen CY
Cancer Res. 2003
PubMed ID: 12750264
Synthesis and functional analyses of nuclear clusterin, a cell death protein.
Leskov KS, Klokov DY, Li J, Kinsella TJ, Boothman DA
J Biol Chem. 2003
PubMed ID: 12551933
Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.
Ko L, Chin WW
J Biol Chem. 2003
PubMed ID: 12519782
Function of DNA-protein kinase catalytic subunit during the early meiotic prophase without Ku70 and Ku86.
Hamer G, Roepers-Gajadien HL, van Duyn-Goedhart A, Gademan IS, Kal HB, van Buul PP, Ashley T, de Rooij DG
Biol Reprod. 2003
PubMed ID: 12604618
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
Calsou P, Delteil C, Frit P, Drouet J, Salles B
J Mol Biol. 2003
PubMed ID: 12547193
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Human neutrophils isolated from peripheral blood contain Ku protein but not DNA-dependent protein kinase.
Kurosawa A, Shinohara K, Watanabe F, Shimizu-Saito K, Koiwai O, Yamamoto K, Teraoka H
Int J Biochem Cell Biol. 2003
PubMed ID: 12467650
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Human Ku70/80 associates physically with telomerase through interaction with hTERT.
Chai W, Ford LP, Lenertz L, Wright WE, Shay JW
J Biol Chem. 2002
PubMed ID: 12377759
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells.
Lim JW, Kim H, Kim KH
J Biol Chem. 2002
PubMed ID: 12324457
Implication of the lymphocyte-specific nuclear body protein Sp140 in an innate response to human immunodeficiency virus type 1.
Madani N, Millette R, Platt EJ, Marin M, Kozak SL, Bloch DB, Kabat D
J Virol. 2002
PubMed ID: 12368356
A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T
J Biol Chem. 2002
PubMed ID: 12171929
Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene.
Norwitz ER, Xu S, Xu J, Spiryda LB, Park JS, Jeong KH, McGee EA, Kaiser UB
J Biol Chem. 2002
PubMed ID: 12145309
Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.
Willis DM, Loewy AP, Charlton-Kachigian N, Shao JS, Ornitz DM, Towler DA
J Biol Chem. 2002
PubMed ID: 12145306
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity.
Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka K, Taniguchi N, Sobue G
J Biol Chem. 2002
PubMed ID: 12145308
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
Zipper LM, Mulcahy RT
J Biol Chem. 2002
PubMed ID: 12145307
Dimerization, translocation and localization of Ku70 and Ku80 proteins.
Koike M
J Radiat Res (Tokyo). 2002
PubMed ID: 12518983
Relationship between DNA mismatch repair genes expression, Ku-genes expression and ploidy-related parameters in the progression of pigmented lesions of the skin.
Korabiowska M, Tscherny M, Stachura J, Ruschenburg I, Cordon-Cardo C, Brinck U
In Vivo. 2002
PubMed ID: 12494870
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.
Karmakar P, Snowden CM, Ramsden DA, Bohr VA
Nucleic Acids Res. 2002
PubMed ID: 12177300
Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.
Inamdar KV, Pouliot JJ, Zhou T, Lees-Miller SP, Rasouli-Nia A, Povirk LF
J Biol Chem. 2002
PubMed ID: 12023295
Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation.
Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A, Klinman DM
J Exp Med. 2002
PubMed ID: 12119352
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy.
Greene WC, Peterlin BM
Nat Med. 2002
PubMed ID: 12091904
Synapsis of DNA ends by DNA-dependent protein kinase.
DeFazio LG, Stansel RM, Griffith JD, Chu G
EMBO J. 2002
PubMed ID: 12065431
Deficiency in nuclear accumulation of G22p1 and Xrcc5 proteins in hyper-radiosensitive Long-Evans Cinnamon (LEC) rat cells after X irradiation.
Okui T, Endoh D, Kon Y, Hayashi M
Radiat Res. 2002
PubMed ID: 11966321
Binding of inositol hexakisphosphate (IP6) to Ku but not to DNA-PKcs.
Ma Y, Lieber MR
J Biol Chem. 2002
PubMed ID: 11821378
Defining interactions between DNA-PK and ligase IV/XRCC4.
Hsu HL, Yannone SM, Chen DJ
DNA Repair (Amst). 2002
PubMed ID: 12509254
Studies on the mode of Ku interaction with DNA.
Arosio D, Cui S, Ortega C, Chovanec M, Di Marco S, Baldini G, Falaschi A, Vindigni A
J Biol Chem. 2002
PubMed ID: 11796732
Directed proteomic analysis of the human nucleolus.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI
Curr Biol. 2002
PubMed ID: 11790298
Divergence in intracellular signaling between interleukin-4 (IL-4) and IL-13 in human cells localizes to monomeric/dimeric expression of a transcription factor, the lupus autoantigen 70/80, induced by both cytokines.
Kelavkar U, Wang S, Badr K
Adv Exp Med Biol. 2002
PubMed ID: 12664629
KU 70/80 lupus autoantigen is the transcription factor induced by interleukins (IL)-13 and -4 leading to induction of 15-lipoxygenase (15-LO) in human cells.
Kelavkar U, Wang S, Badr K
Adv Exp Med Biol. 2002
PubMed ID: 12664628
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.
Pierce AJ, Hu P, Han M, Ellis N, Jasin M
Genes Dev. 2001
PubMed ID: 11751629
The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70.
Zhang Z, Zhu L, Lin D, Chen F, Chen DJ, Chen Y
J Biol Chem. 2001
PubMed ID: 11457852
Involvement of DNA-dependent protein kinase in regulation of stress-induced JNK activation.
Park SJ, Oh EJ, Yoo MA, Lee SH
DNA Cell Biol. 2001
PubMed ID: 11749722
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.
Walker JR, Corpina RA, Goldberg J
Nature. 2001
PubMed ID: 11493912
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.
d'Adda di Fagagna F, Hande MP, Tong WM, Roth D, Lansdorp PM, Wang ZQ, Jackson SP
Curr Biol. 2001
PubMed ID: 11516951
High-throughput sequence identification of gene coding variants within alcohol-related QTLs.
Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson TE, Sikela JM
Mamm Genome. 2001
PubMed ID: 11471062
Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection.
Li L, Olvera JM, Yoder KE, Mitchell RS, Butler SL, Lieber M, Martin SL, Bushman FD
EMBO J. 2001
PubMed ID: 11406603
The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase.
Schild-Poulter C, Pope L, Giffin W, Kochan JC, Ngsee JK, Traykova-Andonova M, Haché RJ
J Biol Chem. 2001
PubMed ID: 11279128
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.
Orren DK, Machwe A, Karmakar P, Piotrowski J, Cooper MP, Bohr VA
Nucleic Acids Res. 2001
PubMed ID: 11328876
Human Ku70 interacts with heterochromatin protein 1alpha.
Song K, Jung Y, Jung D, Lee I
J Biol Chem. 2001
PubMed ID: 11112778
Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells.
Balajee AS, Geard CR
Nucleic Acids Res. 2001
PubMed ID: 11239001
Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase.
Romero F, Multon MC, Ramos-Morales F, Domínguez A, Bernal JA, Pintor-Toro JA, Tortolero M
Nucleic Acids Res. 2001
PubMed ID: 11238996
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.
Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248063
Tumor specific modulation of KU70/80 DNA binding activity in breast and bladder human tumor biopsies.
Pucci S, Mazzarelli P, Rabitti C, Giai M, Gallucci M, Flammia G, Alcini A, Altomare V, Fazio VM
Oncogene. 2001
PubMed ID: 11314007
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku proteins G22p1 (Ku70) and Xrcc5 (Ku80) in rat fibroblasts.
Endoh D, Okui T, Kon Y, Hayashi M
Radiat Res. 2001
PubMed ID: 11175667
Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.
Daniel R, Katz RA, Merkel G, Hittle JC, Yen TJ, Skalka AM
Mol Cell Biol. 2001
PubMed ID: 11158303
Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms.
Tang D, Xie Y, Zhao M, Stevenson MA, Calderwood SK
Biochem Biophys Res Commun. 2001
PubMed ID: 11162511
DNA-Dependent protein kinase is not required for efficient lentivirus integration.
Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z
J Virol. 2000
PubMed ID: 11070027
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Functional interaction between Ku and the werner syndrome protein in DNA end processing.
Li B, Comai L
J Biol Chem. 2000
PubMed ID: 10880505
Interaction of human Ku70 with TRF2.
Song K, Jung D, Jung Y, Lee SG, Lee I
FEBS Lett. 2000
PubMed ID: 10984620
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.
Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10823907
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
Ko L, Cardona GR, Chin WW
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10823961
Ku recruits the XRCC4-ligase IV complex to DNA ends.
Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA
Mol Cell Biol. 2000
PubMed ID: 10757784
Ku complex interacts with and stimulates the Werner protein.
Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA
Genes Dev. 2000
PubMed ID: 10783163
Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors.
Sartorius CA, Takimoto GS, Richer JK, Tung L, Horwitz KB
J Mol Endocrinol. 2000
PubMed ID: 10750018
Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716994
The DNA sequence of human chromosome 22.
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP
Nature. 1999
PubMed ID: 10591208
Association of terminal deoxynucleotidyl transferase with Ku.
Mahajan KN, Gangi-Peterson L, Sorscher DH, Wang J, Gathy KN, Mahajan NP, Reeves WH, Mitchell BS
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10570175
Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis.
Goedecke W, Eijpe M, Offenberg HH, van Aalderen M, Heyting C
Nat Genet. 1999
PubMed ID: 10508516
A novel neuron-specific DNA end-binding factor in the murine brain.
Hurd YL, Yakovleva T, Nussenzweig A, Li GC, Terenius L, Bakalkin G
Mol Cell Neurosci. 1999
PubMed ID: 10576891
Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb.
Morio T, Hanissian SH, Bacharier LB, Teraoka H, Nonoyama S, Seki M, Kondo J, Nakano H, Lee SK, Geha RS, Yata J
Immunity. 1999
PubMed ID: 10514012
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex.
Gell D, Jackson SP
Nucleic Acids Res. 1999
PubMed ID: 10446239
Defining functional domains of Ku80: DNA end binding and survival after radiation.
Osipovich O, Duhe RJ, Hasty P, Durum SK, Muegge K
Biochem Biophys Res Commun. 1999
PubMed ID: 10441505
Ku binds telomeric DNA in vitro.
Bianchi A, de Lange T
J Biol Chem. 1999
PubMed ID: 10409678
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
Galande S, Kohwi-Shigematsu T
J Biol Chem. 1999
PubMed ID: 10400681
Isolation of Ku70-binding proteins (KUBs).
Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ, Boothman DA
Nucleic Acids Res. 1999
PubMed ID: 10219089
Ku, a DNA repair protein with multiple cellular functions?
Featherstone C, Jackson SP
Mutat Res. 1999
PubMed ID: 10377944
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit.
Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE, Jeggo PA
Mol Cell Biol. 1999
PubMed ID: 10207052
A role for DNA-PK in retroviral DNA integration.
Daniel R, Katz RA, Skalka AM
Science. 1999
PubMed ID: 10213687
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y
EMBO J. 1999
PubMed ID: 10064605
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Kurimasa A, Ouyang H, Dong LJ, Wang S, Li X, Cordon-Cardo C, Chen DJ, Li GC
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9990036
DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer.
Chan DW, Ye R, Veillette CJ, Lees-Miller SP
Biochemistry. 1999
PubMed ID: 10026262
The Ku70 autoantigen interacts with p40phox in B lymphocytes.
Grandvaux N, Grizot S, Vignais PV, Dagher MC
J Cell Sci. 1999
PubMed ID: 9914162
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
DNA end-joining catalyzed by human cell-free extracts.
Baumann P, West SC
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9826654
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Frank KM, Sekiguchi JM, Seidl KJ, Swat W, Rathbun GA, Cheng HL, Davidson L, Kangaloo L, Alt FW
Nature. 1998
PubMed ID: 9823897
Expression, localization and functional interactions of Ku70 subunit of DNA-PK in peripheral lymphocytes and Nalm-19 cells after irradiation.
Kumaravel TS, Bharathy K, Kudoh S, Tanaka K, Kamada N
Int J Radiat Biol. 1998
PubMed ID: 9798959
Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini.
West RB, Yaneva M, Lieber MR
Mol Cell Biol. 1998
PubMed ID: 9742108
Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells.
Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S
EMBO J. 1998
PubMed ID: 9736627
Ku70: a candidate tumor suppressor gene for murine T cell lymphoma.
Li GC, Ouyang H, Li X, Nagasawa H, Little JB, Chen DJ, Ling CC, Fuks Z, Cordon-Cardo C
Mol Cell. 1998
PubMed ID: 9702186
Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization.
Bakalkin G, Yakovleva T, Hurd YL, Nussenzweig A, Li GC, Terenius L
Neuroreport. 1998
PubMed ID: 9674610
Ku70 is required for late B cell development and immunoglobulin heavy chain class switching.
Manis JP, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L, Rajewsky K, Alt FW
J Exp Med. 1998
PubMed ID: 9625768
Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.
Fukumura R, Araki R, Fujimori A, Mori M, Saito T, Watanabe F, Sarashi M, Itsukaichi H, Eguchi-Kasai K, Sato K, Tatsumi K, Abe M
J Biol Chem. 1998
PubMed ID: 9582343
Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex.
Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL
Mol Cell Biol. 1998
PubMed ID: 9488450
Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells.
Bandyopadhyay D, Mandal M, Adam L, Mendelsohn J, Kumar R
J Biol Chem. 1998
PubMed ID: 9430697
Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.
Jin S, Weaver DT
EMBO J. 1997
PubMed ID: 9362500
Growth retardation and leaky SCID phenotype of Ku70-deficient mice.
Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW
Immunity. 1997
PubMed ID: 9390689
Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit.
Jin S, Kharbanda S, Mayer B, Kufe D, Weaver DT
J Biol Chem. 1997
PubMed ID: 9312071
Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo.
Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C, Li W, Cheong N, Nussenzweig M, Iliakis G, Chen DJ, Li GC
J Exp Med. 1997
PubMed ID: 9294146
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.
Gu Y, Jin S, Gao Y, Weaver DT, Alt FW
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9223317
The end-joining reaction in V(D)J recombination.
Smider V, Chu G
Semin Immunol. 1997
PubMed ID: 9200330
Chromosomal localization of the mouse and rat DNA double-strand break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA expression in various mouse tissues.
Koike M, Matsuda Y, Mimori T, Harada YN, Shiomi N, Shiomi T
Genomics. 1996
PubMed ID: 8954777
Expression of human glucocorticoid receptor gene and interaction of nuclear proteins with the transcriptional control element.
Warriar N, Pagé N, Govindan MV
J Biol Chem. 1996
PubMed ID: 8702520
Genomic structure and chromosomal assignment of the mouse Ku70 gene.
Takiguchi Y, Kurimasa A, Chen F, Pardington PE, Kuriyama T, Okinaka RT, Moyzis R, Chen DJ
Genomics. 1996
PubMed ID: 8661113
The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.
Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T
J Biol Chem. 1996
PubMed ID: 8621488
Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes.
Oderwald H, Hughes MJ, Jost JP
FEBS Lett. 1996
PubMed ID: 8605992
A tick homologue of the human DNA helicase II 70-kDa subunit.
Paesen GC, Zanotto PM, Nuttall PA
Biochim Biophys Acta. 1996
PubMed ID: 8597595
p95vav associates with the nuclear protein Ku-70.
Romero F, Dargemont C, Pozo F, Reeves WH, Camonis J, Gisselbrecht S, Fischer S
Mol Cell Biol. 1996
PubMed ID: 8524317
Nomenclature of human genes involved in ionizing radiation sensitivity.
Thompson LH, Jeggo PA
Mutat Res. 1995
PubMed ID: 7565861
Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.
Genersch E, Eckerskorn C, Lottspeich F, Herzog C, Kühn K, Pöschl E
EMBO J. 1995
PubMed ID: 7882982
Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.
Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J
EMBO J. 1994
PubMed ID: 7957065
Lupus autoantigen Ku protein binds HIV-1 TAR RNA in vitro.
Kaczmarski W, Khan SA
Biochem Biophys Res Commun. 1993
PubMed ID: 8240370
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.
Gottlieb TM, Jackson SP
Cell. 1993
PubMed ID: 8422676
Immunolocalization of Ku-proteins (p80/p70): localization of p70 to nucleoli and periphery of both interphase nuclei and metaphase chromosomes.
Higashiura M, Shimizu Y, Tanimoto M, Morita T, Yagura T
Exp Cell Res. 1992
PubMed ID: 1639139
The nucleotide sequence of a mouse cDNA encoding the 80 kDa subunit of the Ku (p70/p80) autoantigen.
Falzon M, Kuff EL
Nucleic Acids Res. 1992
PubMed ID: 1641347
Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides.
Griffith AJ, Craft J, Evans J, Mimori T, Hardin JA
Mol Biol Rep. 1992
PubMed ID: 1608402
Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells.
Wedrychowski A, Henzel W, Huston L, Paslidis N, Ellerson D, McRae M, Seong D, Howard OM, Deisseroth A
J Biol Chem. 1992
PubMed ID: 1537839
Genes newly identified as regulated by glucocorticoids in murine thymocytes.
Baughman G, Harrigan MT, Campbell NF, Nurrish SJ, Bourgeois S
Mol Endocrinol. 1991
PubMed ID: 2072923
Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species.
Porges AJ, Ng T, Reeves WH
J Immunol. 1990
PubMed ID: 1701785
Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.
Reeves WH, Sthoeger ZM
J Biol Chem. 1989
PubMed ID: 2466842
Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.
Chan JY, Lerman MI, Prabhakar BS, Isozaki O, Santisteban P, Kuppers RC, Oates EL, Notkins AL, Kohn LD
J Biol Chem. 1989
PubMed ID: 2917966

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2547	14375	25019
EnsEMBL Gene(s)	ENSG00000196419	ENSMUSG00000022471	ENSRNOG00000006392
Unigene	Hs.292493	Mm.288809	Rn.161996
Homologene	XRCC6	Xrcc6	Xrcc6
OMIM	152690	N/A	N/A
GeneCards	XRCC6	N/A	N/A
Beta Cell Genomics	DT.100753842 DT.100891260 DT.100891296 DT.100891297 DT.100891332 DT.120633355 DT.40237757 DT.91648729 DT.91893522 DT.91936042 DT.92002298 DT.95236564 DT.97801829 DT.97868396	DT.101390581 DT.491519 DT.94216367	N/A
Reactome	P12956	N/A	N/A
Plasma Peptide Atlas	ENSP00000352257	N/A	N/A
WikiGenes	2547	14375	25019

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
XRCC6	HDAC5	BioGRID	empirical	21081666
XRCC6	CHAF1A	BioGRID	empirical	21209461
XRCC6	CDK2	BioGRID	empirical	15159402
XRCC6	CDKN1A	HPRD	empirical	9798959
XRCC6	NDRG1	IntAct	empirical	17220478
XRCC6	TADA3	MINT, IntAct	empirical	15383276
XRCC6	CEBPA	IntAct	empirical	16490787
XRCC6	CBX1	IntAct	empirical	21888893
XRCC6	ILVBL	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	CHEK1	HPRD, BioGRID	empirical	12756247
XRCC6	CAPN11	IntAct	empirical	21988832
XRCC6	BAZ1A	BioGRID	empirical	21172662
XRCC6	WBP4	MINT, BioGRID	empirical	16055720
XRCC6	ADCY7	IntAct	empirical	21988832
XRCC6	CDCA5	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	CBX3	IntAct	empirical	21888893
XRCC6	GABARAP	IntAct	empirical	20562859
XRCC6	GABARAPL2	IntAct	empirical	20562859
XRCC6	ARAP1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	CLU	HPRD	empirical	10219089 12551933
XRCC6	CLTC	HPRD, MINT, IntAct	empirical	15383276
XRCC6	COPB1	IntAct	empirical	21988832
XRCC6	CREBBP	BioGRID	empirical	9488450 15023334
XRCC6	PARP1	HPRD, IntAct, BioGRID	empirical	17283121 14734561 16794079 10400681
XRCC6	CSNK2A1	IntAct	empirical	20711232
XRCC6	CTBP2	IntAct	empirical	21988832
XRCC6	SGOL1	HPRD	empirical	16541024
XRCC6	DDB2	BioGRID	empirical	20368362
XRCC6	DHX9	BioGRID	empirical	15723802
XRCC6	DLX2	BioGRID	empirical	11279128
XRCC6	DNTT	HPRD, BioGRID	empirical	10570175
XRCC6	EFNA1	BioGRID	empirical	21900206
XRCC6	EGFR	HPRD	empirical	9430697
XRCC6	EP300	IntAct, BioGRID	empirical	21988832 15023334
XRCC6	EPS8	IntAct	empirical	21988832
XRCC6	ERG	IntAct	empirical	21575865
XRCC6	ESR1	BioGRID	empirical	16794079
XRCC6	ETS1	IntAct	empirical	21575865
XRCC6	ETV1	IntAct	empirical	21575865
XRCC6	RRAS2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	NCOA6	HPRD, BioGRID	empirical	12519782 10823961
XRCC6	KIAA0182	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	SIRT3	BioGRID	empirical	18710944
XRCC6	SIRT1	IntAct	empirical	17334224 15205477
XRCC6	CBX5	HPRD, BioGRID	empirical	11112778
XRCC6	SRRM2	BioGRID	empirical	16159877
XRCC6	ORC6	BioGRID	empirical	15910003
XRCC6	GABARAPL1	IntAct	empirical	20562859
XRCC6	EID1	BioGRID	empirical	21900206
XRCC6	ABL1	HPRD, BioGRID	empirical	9798959
XRCC6	KAT2A	HPRD, MIPS, BioGRID	empirical	9488450 9488451
XRCC6	BIN1	BioGRID	empirical	17671430
XRCC6	GRB2	IntAct	empirical	12577067
XRCC6	TFCP2L1	BioGRID	empirical	20362541
XRCC6	ANXA1	BioGRID	empirical	21900206
XRCC6	H2AFX	BioGRID	empirical	15613478 18406329 20224553
XRCC6	HTT	HPRD, MINT, IntAct, BioGRID	empirical	15383276
XRCC6	HDGF	IntAct	empirical	21907836
XRCC6	HMGA1	IntAct	empirical	18850631
XRCC6	HOXB7	IntAct, BioGRID	empirical	17308091
XRCC6	HOXC4	HPRD, BioGRID	empirical	11279128
XRCC6	HOXD4	BioGRID	empirical	11279128
XRCC6	APEX1	HPRD	empirical	8621488
XRCC6	HSF1	HPRD, BioGRID	empirical	11162511
XRCC6	BIRC5	BioGRID	empirical	20394854
XRCC6	ILF2	BioGRID	empirical	17389650
XRCC6	PDX1	BioGRID	empirical	16166097
XRCC6	AR	HPRD	empirical	15640154
XRCC6	LIG3	BioGRID	empirical	12897160
XRCC6	LIG4	BioGRID	empirical	15520013
XRCC6	LMNA	BioGRID	empirical	21327095
XRCC6	SMAD3	HPRD, MINT	empirical	15231748
XRCC6	ARRB2	IntAct	empirical	17620599
XRCC6	SMAD7	HPRD, MINT	empirical	15231748
XRCC6	MDM2	BioGRID	empirical	19247369
XRCC6	MGMT	BioGRID	empirical	16226712
XRCC6	ATXN3	BioGRID	empirical	17885668
XRCC6	MRE11A	HPRD	empirical	10508516
XRCC6	MSX2	HPRD, BioGRID	empirical	12145307 12145306
XRCC6	MYC	IntAct, BioGRID	empirical	17314511
XRCC6	NCF4	HPRD, BioGRID	empirical	9914162
XRCC6	NHP2L1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	NIT1	HPRD, IntAct, BioGRID	empirical	16169070
XRCC6	NOTCH1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	ORC2	BioGRID	empirical	15910003
XRCC6	ORC4	BioGRID	empirical	15910003
XRCC6	PAEP	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	PAFAH1B3	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	PCNA	HPRD, BioGRID	empirical	11239001 12171929
XRCC6	SIRT6	BioGRID	empirical	20157594
XRCC6	PDK1	BioGRID	empirical	21900206
XRCC6	PECAM1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	PGAM1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	PGR	HPRD	empirical	10750018
XRCC6	SERPINB9	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	ATP6V1E1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	TERF2IP	IntAct, BioGRID	empirical	15383534 15100233
XRCC6	POR	HPRD, MINT, IntAct	empirical	16169070
XRCC6	POU2F1	HPRD, BioGRID	empirical	12672812 11279128 17213819
XRCC6	POU2F2	HPRD, BioGRID	empirical	11279128
XRCC6	POU5F1	IntAct, BioGRID	empirical	20362542
XRCC6	CMTM6	BioGRID	empirical	21900206
XRCC6	QRSL1	BioGRID	empirical	21900206
XRCC6	SMPD3	IntAct	empirical	16169070
XRCC6	PNRC2	BioGRID	empirical	21900206
XRCC6	PRPF40A	BioGRID	empirical	16055720
XRCC6	PRKAR1A	IntAct	empirical	20195357
XRCC6	C9orf46	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	PRKDC	HPRD, IntAct, BioGRID	empirical	11279128 10446239 9312071 17308091 19303849 20711232 21575865 10064605 15520013 8422676
XRCC6	MAPK8	HPRD	empirical	11749722
XRCC6	MAPK13	IntAct, BioGRID	empirical	19135240
XRCC6	MAP2K5	IntAct	empirical	21988832
XRCC6	PSMA3	BioGRID	empirical	22079093
XRCC6	SMARCAD1	BioGRID	empirical	21549307
XRCC6	ZNF512B	MINT	empirical	15231748
XRCC6	CRAMP1L	MINT	empirical	16169070
XRCC6	BARD1	HPRD, IntAct, BioGRID	empirical	15782130
XRCC6	BAX	IntAct, BioGRID	empirical	15205477 19247369
XRCC6	ABCD4	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	RASA1	BioGRID	empirical	21900206
XRCC6	RBBP4	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	RGS2	BioGRID	empirical	21900206
XRCC6	RPA2	BioGRID	empirical	10064605
XRCC6	RPLP1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	RPS10	BioGRID	empirical	21900206
XRCC6	SDHC	BioGRID	empirical	21900206
XRCC6	SKIL	HPRD, MINT	empirical	15231748
XRCC6	ACD	HPRD, MINT, IntAct	empirical	16169070
XRCC6	SNTA1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	SPARC	BioGRID	empirical	21900206
XRCC6	SPI1	IntAct	empirical	21575865
XRCC6	TAC1	BioGRID	empirical	21900206
XRCC6	TAL1	MINT, BioGRID	empirical	16407974
XRCC6	TBCD	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	TCF4	HPRD	empirical	17283121
XRCC6	TCF7L2	IntAct	empirical	17283121
XRCC6	BTG1	BioGRID	empirical	21900206
XRCC6	TERF2	HPRD, BioGRID	empirical	11112778 10984620
XRCC6	TERT	BioGRID	empirical	12377759
XRCC6	THRA	BioGRID	empirical	17242407
XRCC6	THRB	BioGRID	empirical	17242407
XRCC6	TP53	HPRD, IntAct, BioGRID	empirical	15782130 18162465
XRCC6	CCT3	HPRD, MINT, IntAct	empirical	15383276
XRCC6	UBC	BioGRID	empirical	16196087 19247369 22178446 22118674 22108332 18781797 21987572 21139048 21890473 21906983
XRCC6	USF1	IntAct, BioGRID	empirical	19303849
XRCC6	VAV1	HPRD, BioGRID	empirical	8524317
XRCC6	VBP1	BioGRID	empirical	21900206
XRCC6	WRN	HPRD, IntAct, BioGRID	empirical	12177300 10783163 11328876 14734561 10880505
XRCC6	XRCC4	BioGRID	empirical	15520013
XRCC6	FMNL1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	XRCC5	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	10446239 12519782 10207052 8702520 12145306 17159921 11493912 17283121 17308091 21679440 10783163 14681455 9488451 9488450 10219089 10984620 15520013 15023334 21172662 21070772 21454661 15367688 15910003
XRCC6	YY1	BioGRID	empirical	15367688
XRCC6	YWHAZ	HPRD, MINT, IntAct, BioGRID	empirical	16169070
XRCC6	MLF1IP	BioGRID	empirical	21900206
XRCC6	GAL3ST4	HPRD, BioGRID	empirical	16169070
XRCC6	NAA15	HPRD, BioGRID	empirical	12145309 12145306
XRCC6	COIL	BioGRID	empirical	21070772
XRCC6	MAP1LC3B	IntAct	empirical	20562859
XRCC6	RNF146	BioGRID	empirical	21825151
XRCC6	HIST1H3A	BioGRID	empirical	21187428
XRCC6	HIST1H3E	BioGRID	empirical	20504901
XRCC6	C11orf68	BioGRID	empirical	20360068
XRCC6	RUNX2	HPRD, BioGRID	empirical	12145308 12145306
XRCC6	KAT2B	BioGRID	empirical	15023334
XRCC6	CCNA1	HPRD, BioGRID	empirical	15159402
XRCC6	FCHSD1	BioGRID	empirical	19041431
XRCC6	HN1L	HPRD, IntAct	empirical	16169070
XRCC6	XRCC6BP1	HPRD, BioGRID	empirical	10219089
XRCC6	PTTG1	HPRD, BioGRID	empirical	11238996
XRCC6	SEP15	BioGRID	empirical	21900206
XRCC6	CHD1L	BioGRID	empirical	19666485 19661379
XRCC6	CD40	HPRD, BioGRID	empirical	10514012
XRCC6	RBM39	BioGRID	empirical	16051665
XRCC6	HERPUD1	BioGRID	empirical	21900206
XRCC6	KIAA0408	BioGRID	empirical	21900206
XRCC6	KIAA0101	BioGRID	empirical	21628590
XRCC6	NR1H4	BioGRID	empirical	19833092