FYN

Summary Top Help

Gene Description:

FYN oncogene related to SRC, FGR, YES; Fyn proto-oncogene

Synonyms:

AI448320, FYN, SYN, p59-FYN, AW552119, Fyn, SLK

Orthologs:

Human FYN (protein-coding), Mouse Fyn (protein-coding), Rat Fyn (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr6:111981535..112194655 (213.12 kb) View in Genome Browser

(Mouse) NCBIM37 - chr10:39088661..39285187 (196.53 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:43501853..43695567 (193.71 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for FYN:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for FYN:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 12

Biocarta: 9

Reactome: 28

NCI-Nature Pathway Interaction Database: 26

Gene Ontology: 26

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 785

TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.
Azhibekov TA, Wu Z, Padiyar A, Bruggeman LA, Simske JS
Am J Physiol Cell Physiol. 2011
PubMed ID: 21881001
Heterogeneous expression of Src tyrosine kinases Lyn, Fyn and Syk in classical Hodgkin lymphoma: prognostic implications.
Martín P, Salas C, Provencio M, Abraira V, Bellas C
Leuk Lymphoma. 2011
PubMed ID: 21749309
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
Mori T, Ikeda DD, Fukushima T, Takenoshita S, Kochi H
Cell Cycle. 2011
PubMed ID: 21952639
Fyn requires HnRNPA2B1 and Sam68 to synergistically regulate apoptosis in pancreatic cancer.
Chen ZY, Cai L, Zhu J, Chen M, Chen J, Li ZH, Liu XD, Wang SG, Bie P, Jiang P, Dong JH, Li XW
Carcinogenesis. 2011
PubMed ID: 21642356
1H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide.
Huculeci R, Buts L, Lenaerts T, van Nuland NA
Biomol NMR Assign. 2011
PubMed ID: 21298565
Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice.
Babus LW, Little EM, Keenoy KE, Minami SS, Chen E, Song JM, Caviness J, Koo SY, Pak DT, Rebeck GW, Turner RS, Hoe HS
Brain Res. 2011
PubMed ID: 21872217
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
A new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.
Bamberger M, Santos AM, Gonçalves CM, Oliveira MI, James JR, Moreira A, Lozano F, Davis SJ, Carmo AM
J Biol Chem. 2011
PubMed ID: 21757751
Nephrin expression in adult rodent central nervous system and its interaction with glutamate receptors.
Li M, Armelloni S, Ikehata M, Corbelli A, Pesaresi M, Calvaresi N, Giardino L, Mattinzoli D, Nisticò F, Andreoni S, Puliti A, Ravazzolo R, Forloni G, Messa P, Rastaldi MP
J Pathol. 2011
PubMed ID: 21630272
Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes.
Minami SS, Hoe HS, Rebeck GW
J Neurochem. 2011
PubMed ID: 21534960
Identification of Fyn as the binding partner for the WASP N-terminal domain in T cells.
Sato M, Sawahata R, Takenouchi T, Kitani H
Int Immunol. 2011
PubMed ID: 21705469
Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau.
Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W, Williamson R
FEBS J. 2011
PubMed ID: 21692989
Fyn, a Potential Target for Alzheimer's Disease.
Yang K, Belrose J, Trepanier CH, Lei G, Jackson MF, Macdonald JF
J Alzheimers Dis. 2011
PubMed ID: 21799250
Gab2, via PI-3K, regulates ARF1 in FcεRI-mediated granule translocation and mast cell degranulation.
Nishida K, Yamasaki S, Hasegawa A, Iwamatsu A, Koseki H, Hirano T
J Immunol. 2011
PubMed ID: 21653832
Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.
Kim S, Kunapuli SP
J Biol Chem. 2011
PubMed ID: 21592972
Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1).
Curtiss ML, Hostager BS, Stepniak E, Singh M, Manhica N, Knisz J, Traver G, Rennert PD, Colgan JD, Rothman PB
Mol Immunol. 2011
PubMed ID: 21513984
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state.
Chen K, Li W, Major J, Rahaman SO, Febbraio M, Silverstein RL
Blood. 2011
PubMed ID: 21427288
Fyn is downstream of the HGF/MET signaling axis and affects cellular shape and tropism in PC3 cells.
Jensen AR, David SY, Liao C, Dai J, Keller ET, Al-Ahmadie H, Dakin-Haché K, Usatyuk P, Sievert MF, Paner GP, Yala S, Cervantes GM, Natarajan V, Salgia R, Posadas EM
Clin Cancer Res. 2011
PubMed ID: 21364031
Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration.
Yadav V, Denning MF
Mol Carcinog. 2011
PubMed ID: 21480388
Differential transformation capacity of Src family kinases during the initiation of prostate cancer.
Cai H, Smith DA, Memarzadeh S, Lowell CA, Cooper JA, Witte ON
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21464326
Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells.
Kim AN, Jeon WK, Lim KH, Lee HY, Kim WJ, Kim BC
Biochem Biophys Res Commun. 2011
PubMed ID: 21371426
Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression.
Kaspar JW, Jaiswal AK
FASEB J. 2011
PubMed ID: 21097520
Centrosome docking at the immunological synapse is controlled by Lck signaling.
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
J Cell Biol. 2011
PubMed ID: 21339332
Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling.
Séverin S, Pollitt AY, Navarro-Nuñez L, Nash CA, Mourão-Sá D, Eble JA, Senis YA, Watson SP
J Biol Chem. 2011
PubMed ID: 21098033
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.
Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L
J Neurosci. 2011
PubMed ID: 21228179
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA
PLoS One. 2011
PubMed ID: 21915273
The conformation and activation of Fyn kinase in the oocyte determine its localisation to the spindle poles and cleavage furrow.
Levi M, Maro B, Shalgi R
Reprod Fertil Dev. 2011
PubMed ID: 21871204
Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.
Samarakoon R, Chitnis SS, Higgins SP, Higgins CE, Krepinsky JC, Higgins PJ
PLoS One. 2011
PubMed ID: 21829547
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.
Yang HB, Yang X, Cao J, Li S, Liu YN, Suo ZW, Cui HB, Guo Z, Hu XD
J Neurochem. 2011
PubMed ID: 21054385
Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration.
Yeo MG, Oh HJ, Cho HS, Chun JS, Marcantonio EE, Song WK
J Cell Physiol. 2011
PubMed ID: 20658524
Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC.
Fenouille N, Puissant A, Dufies M, Robert G, Jacquel A, Ohanna M, Deckert M, Pasquet JM, Mahon FX, Cassuto JP, Raynaud S, Tartare-Deckert S, Auberger P
Cancer Res. 2010
PubMed ID: 21098700
Fyn kinase is involved in cleavage furrow ingression during meiosis and mitosis.
Levi M, Maro B, Shalgi R
Reproduction. 2010
PubMed ID: 20841362
Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells.
Kim HJ, Warren JT, Kim SY, Chappel JC, DeSelm CJ, Ross FP, Zou W, Teitelbaum SL
J Cell Biochem. 2010
PubMed ID: 20717919
CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.
Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M, Silverstein RL
J Clin Invest. 2010
PubMed ID: 20978343
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.
Yang X, Dutta U, Shaw LM
Mol Cell Biol. 2010
PubMed ID: 20855525
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells.
Suzuki R, Liu X, Olivera A, Aguiniga L, Yamashita Y, Blank U, Ambudkar I, Rivera J
J Leukoc Biol. 2010
PubMed ID: 20571036
VEGF secretion during hypoxia depends on free radicals-induced Fyn kinase activity in mast cells.
García-Román J, Ibarra-Sánchez A, Lamas M, González Espinosa C
Biochem Biophys Res Commun. 2010
PubMed ID: 20850416
Glucocorticoids downregulate Fyn and inhibit IP(3)-mediated calcium signaling to promote autophagy in T lymphocytes.
Harr MW, McColl KS, Zhong F, Molitoris JK, Distelhorst CW
Autophagy. 2010
PubMed ID: 20814235
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.
Cannons JL, Wu JZ, Gomez-Rodriguez J, Zhang J, Dong B, Liu Y, Shaw S, Siminovitch KA, Schwartzberg PL
J Immunol. 2010
PubMed ID: 20668219
Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.
Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL
Mol Cell Biol. 2010
PubMed ID: 20606012
Myristoylation and membrane binding regulate c-Src stability and kinase activity.
Patwardhan P, Resh MD
Mol Cell Biol. 2010
PubMed ID: 20584982
Fyn promotes phosphorylation of collapsin response mediator protein 1 at tyrosine 504, a novel, isoform-specific regulatory site.
Buel GR, Rush J, Ballif BA
J Cell Biochem. 2010
PubMed ID: 20506281
Well-known signaling proteins exert new functions in the nucleus and mitochondria.
Büchner N, Altschmied J, Jakob S, Saretzki G, Haendeler J
Antioxid Redox Signal. 2010
PubMed ID: 19958149
Stress-evoked tyrosine phosphorylation of signal regulatory protein alpha regulates behavioral immobility in the forced swim test.
Ohnishi H, Murata T, Kusakari S, Hayashi Y, Takao K, Maruyama T, Ago Y, Koda K, Jin FJ, Okawa K, Oldenborg PA, Okazawa H, Murata Y, Furuya N, Matsuda T, Miyakawa T, Matozaki T
J Neurosci. 2010
PubMed ID: 20685990
Expression of Fyn kinase modulates EMT in oral cancer cells.
Lewin B, Siu A, Baker C, Dang D, Schnitt R, Eisapooran P, Ramos DM
Anticancer Res. 2010
PubMed ID: 20682987
FYN-dependent muscle-immune interaction after sciatic nerve injury.
Hanwei H, Zhao H
Muscle Nerve. 2010
PubMed ID: 20544909
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Mund T, Pelham HR
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534535
PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals.
Kovalovsky D, Alonzo ES, Uche OU, Eidson M, Nichols KE, Sant'Angelo DB
J Immunol. 2010
PubMed ID: 20495068
Fyn kinase contributes to tyrosine phosphorylation of the GABA(A) receptor gamma2 subunit.
Jurd R, Tretter V, Walker J, Brandon NJ, Moss SJ
Mol Cell Neurosci. 2010
PubMed ID: 20233604
The limited contribution of Fyn and Gab2 to the high affinity IgE receptor signaling in mast cells.
Barbu EA, Zhang J, Siraganian RP
J Biol Chem. 2010
PubMed ID: 20335178
Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes.
Audard V, Zhang SY, Copie-Bergman C, Rucker-Martin C, Ory V, Candelier M, Baia M, Lang P, Pawlak A, Sahali D
Blood. 2010
PubMed ID: 20200355
Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
Murata Y, Mori M, Kotani T, Supriatna Y, Okazawa H, Kusakari S, Saito Y, Ohnishi H, Matozaki T
Genes Cells. 2010
PubMed ID: 20398064
Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.
Ruschmann J, Ho V, Antignano F, Kuroda E, Lam V, Ibaraki M, Snyder K, Kim C, Flavell RA, Kawakami T, Sly L, Turhan AG, Krystal G
Exp Hematol. 2010
PubMed ID: 20304029
Entry of Neisseria meningitidis into mammalian cells requires the Src family protein tyrosine kinases.
Slanina H, König A, Hebling S, Hauck CR, Frosch M, Schubert-Unkmeir A
Infect Immun. 2010
PubMed ID: 20176789
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes.
Levi M, Maro B, Shalgi R
Cell Cycle. 2010
PubMed ID: 20372074
Fyn: a novel molecular target in cancer.
Saito YD, Jensen AR, Salgia R, Posadas EM
Cancer. 2010
PubMed ID: 20151426
FcepsilonRI beta-chain ITAM amplifies PI3K-signaling to ensure synergistic degranulation response via FcepsilonRI and adenosine receptors.
Nunomura S, Gon Y, Yoshimaru T, Kashiwakura J, Kawakami T, Ra C
Eur J Immunol. 2010
PubMed ID: 20101614
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A
Immunity. 2010
PubMed ID: 20346773
Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH, Jang JW, Li YH, Chi XZ, Lee KS, Wee H, Ito Y, Oh BC, Bae SC
J Biol Chem. 2010
PubMed ID: 20100835
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.
Yamada E, Pessin JE, Kurland IJ, Schwartz GJ, Bastie CC
Cell Metab. 2010
PubMed ID: 20142099
Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells.
Kettner A, Di Matteo M, Santoni A
Mol Immunol. 2010
PubMed ID: 20004975
Roles of Fyn in pancreatic cancer metastasis.
Chen ZY, Cai L, Bie P, Wang SG, Jiang Y, Dong JH, Li XW
J Gastroenterol Hepatol. 2010
PubMed ID: 19968749
Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice.
Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL
Eur J Immunol. 2010
PubMed ID: 19904769
beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.
Porro F, Rosato-Siri M, Leone E, Costessi L, Iaconcig A, Tongiorgi E, Muro AF
Genes Brain Behav. 2010
PubMed ID: 19900187
The role of Fyn kinase in the release from metaphase in mammalian oocytes.
Levi M, Shalgi R
Mol Cell Endocrinol. 2010
PubMed ID: 19733625
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake.
Abrami L, Kunz B, van der Goot FG
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080640
Fyn kinase controls FcepsilonRI receptor-operated calcium entry necessary for full degranulation in mast cells.
Sanchez-Miranda E, Ibarra-Sanchez A, Gonzalez-Espinosa C
Biochem Biophys Res Commun. 2010
PubMed ID: 20043875
Role of Fyn kinase in oocyte developmental potential.
Luo J, McGinnis LK, Kinsey WH
Reprod Fertil Dev. 2010
PubMed ID: 20591331
Dopamine D1 receptor-mediated NMDA receptor insertion depends on Fyn but not Src kinase pathway in prefrontal cortical neurons.
Hu JL, Liu G, Li YC, Gao WJ, Huang YQ
Mol Brain. 2010
PubMed ID: 20569495
Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strength.
Laird RM, Hayes SM
PLoS One. 2010
PubMed ID: 20126650
Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.
Couch FJ, Wang X, Bamlet WR, de Andrade M, Petersen GM, McWilliams RR
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20056645
Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.
Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K
J Clin Invest. 2010
PubMed ID: 20038804
Fyn and CD70 expression in CD4+ T cells from patients with systemic lupus erythematosus.
Kozlowska A, Hrycaj P, Lacki JK, Jagodzinski PP
J Rheumatol. 2010
PubMed ID: 19955046
Beta-amyloid protein (25-35) disrupts hippocampal network activity: role of Fyn-kinase.
Peña F, Ordaz B, Balleza-Tapia H, Bernal-Pedraza R, Márquez-Ramos A, Carmona-Aparicio L, Giordano M
Hippocampus. 2010
PubMed ID: 19294646
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.
Salmond RJ, Emery J, Okkenhaug K, Zamoyska R
J Immunol. 2009
PubMed ID: 19917692
Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.
Brignatz C, Paronetto MP, Opi S, Cappellari M, Audebert S, Feuillet V, Bismuth G, Roche S, Arold ST, Sette C, Collette Y
Mol Cell Biol. 2009
PubMed ID: 19805512
Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.
Wang PS, Wang J, Xiao ZC, Pallen CJ
J Biol Chem. 2009
PubMed ID: 19812040
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
Knezevic N, Tauseef M, Thennes T, Mehta D
J Exp Med. 2009
PubMed ID: 19917775
Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.
Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC, Lee SC, Ryu SE, Yu DY, Chung BH, Kim E, Myung PK, Lee JR
EMBO J. 2009
PubMed ID: 19816407
Fyn kinase is involved in oligodendroglial cell differentiation induced by apotransferrin.
Perez MJ, Ortiz EH, Roffé M, Soto EF, Pasquini JM
J Neurosci Res. 2009
PubMed ID: 19115405
E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.
Bandi SR, Brandts C, Rensinghoff M, Grundler R, Tickenbrock L, Köhler G, Duyster J, Berdel WE, Müller-Tidow C, Serve H, Sargin B, Study Alliance Leukemias
Blood. 2009
PubMed ID: 19734451
Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ
PLoS Genet. 2009
PubMed ID: 19956733
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.
Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y
J Biol Chem. 2009
PubMed ID: 19652227
Fyn kinase function in lipid utilization: a new upstream regulator of AMPK activity?
Vatish M, Yamada E, Pessin JE, Bastie CC
Arch Physiol Biochem. 2009
PubMed ID: 19728795
Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion.
Chari R, Kim S, Murugappan S, Sanjay A, Daniel JL, Kunapuli SP
Blood. 2009
PubMed ID: 19587372
Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development.
Relucio J, Tzvetanova ID, Ao W, Lindquist S, Colognato H
J Neurosci. 2009
PubMed ID: 19776266
Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients.
Lu KV, Zhu S, Cvrljevic A, Huang TT, Sarkaria S, Ahkavan D, Dang J, Dinca EB, Plaisier SB, Oderberg I, Lee Y, Chen Z, Caldwell JS, Xie Y, Loo JA, Seligson D, Chakravari A, Lee FY, Weinmann R, Cloughesy TF, Nelson SF, Bergers G, Graeber T, Furnari FB, James CD, Cavenee WK, Johns TG, Mischel PS
Cancer Res. 2009
PubMed ID: 19690143
Expression of full-length and truncated Fyn tyrosine kinase transcripts and encoded proteins during spermatogenesis and localization during acrosome biogenesis and fertilization.
Kierszenbaum AL, Rivkin E, Talmor-Cohen A, Shalgi R, Tres LL
Mol Reprod Dev. 2009
PubMed ID: 19441121
Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex.
Luo J, McGinnis LK, Kinsey WH
Mol Reprod Dev. 2009
PubMed ID: 19363790
Decreased expression of Fyn protein and disbalanced alternative splicing patterns in platelets from patients with schizophrenia.
Hattori K, Fukuzako H, Hashiguchi T, Hamada S, Murata Y, Isosaka T, Yuasa S, Yagi T
Psychiatry Res. 2009
PubMed ID: 19501919
An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation.
Laursen LS, Chan CW, ffrench-Constant C
J Neurosci. 2009
PubMed ID: 19625508
Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors.
Grosso S, Puissant A, Dufies M, Colosetti P, Jacquel A, Lebrigand K, Barbry P, Deckert M, Cassuto JP, Mari B, Auberger P
Mol Cancer Ther. 2009
PubMed ID: 19567819
Profiling of the early transcriptional response of murine gammadelta T cells following TCR stimulation.
Laird RM, Hayes SM
Mol Immunol. 2009
PubMed ID: 19439358
Protein tyrosine phosphatase-alpha complexes with the IGF-I receptor and undergoes IGF-I-stimulated tyrosine phosphorylation that mediates cell migration.
Chen SC, Khanna RS, Bessette DC, Samayawardhena LA, Pallen CJ
Am J Physiol Cell Physiol. 2009
PubMed ID: 19420001
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions.
Hsu KL, Fan HJ, Chen YC, Huang YS, Chen CH, Wu JC, Wang SM
Int J Biochem Cell Biol. 2009
PubMed ID: 19166962
The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients.
Szczepankiewicz A, Skibinska M, Suwalska A, Hauser J, Rybakowski JK
Hum Psychopharmacol. 2009
PubMed ID: 19330793
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.
Sun J, Hopkins BD, Tsujikawa K, Perruzzi C, Adini I, Swerlick R, Bornstein P, Lawler J, Benjamin LE
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19304944
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
SRC family kinases are required for limb trajectory selection by spinal motor axons.
Kao TJ, Palmesino E, Kania A
J Neurosci. 2009
PubMed ID: 19403835
Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation.
Charles N, Watford WT, Ramos HL, Hellman L, Oettgen HC, Gomez G, Ryan JJ, O'Shea JJ, Rivera J
Immunity. 2009
PubMed ID: 19362019
Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.
Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T, Yamaguchi N
J Cell Sci. 2009
PubMed ID: 19258394
Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.
Riento K, Frick M, Schafer I, Nichols BJ
J Cell Sci. 2009
PubMed ID: 19258392
Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.
Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S
J Biol Chem. 2009
PubMed ID: 19179337
Influence of membrane surface charge and post-translational modifications to myelin basic protein on its ability to tether the Fyn-SH3 domain to a membrane in vitro.
Homchaudhuri L, Polverini E, Gao W, Harauz G, Boggs JM
Biochemistry. 2009
PubMed ID: 19178193
Functions of Fyn kinase in the completion of meiosis in mouse oocytes.
McGinnis LK, Kinsey WH, Albertini DF
Dev Biol. 2009
PubMed ID: 19118543
Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells.
Gao Y, Howard A, Ban K, Chandra J
J Biol Chem. 2009
PubMed ID: 19131339
T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.
Salmond RJ, Filby A, Qureshi I, Caserta S, Zamoyska R
Immunol Rev. 2009
PubMed ID: 19290918
Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn.
Hayward RD, Hume PJ, Humphreys D, Phillips N, Smith K, Koronakis V
Cell Microbiol. 2009
PubMed ID: 19016778
Characterization of Fyn signaling on the age-dependent immuno-modulation on traumatic rats.
Xiao S, Wang J, Jiang J, Cao X, Wu G, Zhao H
Brain Res. 2009
PubMed ID: 19109931
Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA.
Rajasekharan S, Baker KA, Horn KE, Jarjour AA, Antel JP, Kennedy TE
Development. 2009
PubMed ID: 19141671
Grp94 is Tyr-phosphorylated by Fyn in the lumen of the endoplasmic reticulum and translocates to Golgi in differentiating myoblasts.
Frasson M, Vitadello M, Brunati AM, La Rocca N, Tibaldi E, Pinna LA, Gorza L, Donella-Deana A
Biochim Biophys Acta. 2009
PubMed ID: 19000718
Fyn mediates leptin actions in the thymus of rodents.
Girasol A, Albuquerque GG, Mansour E, Araújo EP, Degasperi G, Denis RG, Carvalheira JB, Saad MJ, Velloso LA
PLoS One. 2009
PubMed ID: 19888448
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Voss M, Lettau M, Janssen O
BMC Immunol. 2009
PubMed ID: 19807924
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking.
Kim JK, Klinger M, Benjamin J, Xiao Y, Erle DJ, Littman DR, Killeen N
PLoS One. 2009
PubMed ID: 19668367
The microtubule-associated protein tau is also phosphorylated on tyrosine.
Lebouvier T, Scales TM, Williamson R, Noble W, Duyckaerts C, Hanger DP, Reynolds CH, Anderton BH, Derkinderen P
J Alzheimers Dis. 2009
PubMed ID: 19542604
FYN kinase gene: another glutamatergic gene associated with bipolar disorder?
Szczepankiewicz A, Rybakowski JK, Skibinska M, Dmitrzak-Weglarz M, Leszczynska-Rodziewicz A, Wilkosc M, Hauser J
Neuropsychobiology. 2009
PubMed ID: 19468241
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization.
Vacaresse N, Møller B, Danielsen EM, Okada M, Sap J
J Biol Chem. 2008
PubMed ID: 18948260
Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1.
Wagner MC, Rhodes G, Wang E, Pruthi V, Arif E, Saleem MA, Wean SE, Garg P, Verma R, Holzman LB, Gattone V, Molitoris BA, Nihalani D
J Biol Chem. 2008
PubMed ID: 18922801
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase.
Macurek L, Dráberová E, Richterová V, Sulimenko V, Sulimenko T, Dráberová L, Marková V, Dráber P
Biochem J. 2008
PubMed ID: 18636972
Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
Li J, Niu XL, Madamanchi NR
J Biol Chem. 2008
PubMed ID: 18854310
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.
Knock GA, Snetkov VA, Shaifta Y, Drndarski S, Ward JP, Aaronson PI
Cardiovasc Res. 2008
PubMed ID: 18682436
Inhibition of DNA methyltransferase activity upregulates Fyn tyrosine kinase expression in Hut-78 T-lymphoma cells.
Kozłowska A, Jagodziński PP
Biomed Pharmacother. 2008
PubMed ID: 18337055
Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cells.
Saksena S, Gill RK, Tyagi S, Alrefai WA, Ramaswamy K, Dudeja PK
Biochem J. 2008
PubMed ID: 18564062
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells.
Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL
J Immunol. 2008
PubMed ID: 18832694
Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men.
Pastor IJ, Laso FJ, Inés S, Marcos M, González-Sarmiento R
Eur Psychiatry. 2008
PubMed ID: 18849153
Protein kinases and addiction.
Lee AM, Messing RO
Ann N Y Acad Sci. 2008
PubMed ID: 18991950
Arrestin-3 is essential for the activation of Fyn by the luteinizing hormone receptor (LHR) in MA-10 cells.
Galet C, Ascoli M
Cell Signal. 2008
PubMed ID: 18647647
Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts.
Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Ballek O, Davidson D, Veillette A, Julius M
J Biol Chem. 2008
PubMed ID: 18660530
Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
Vieira AR, McHenry TG, Daack-Hirsch S, Murray JC, Marazita ML
Genet Med. 2008
PubMed ID: 18978678
Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning.
Isosaka T, Hattori K, Kida S, Kohno T, Nakazawa T, Yamamoto T, Yagi T, Yuasa S
Eur J Neurosci. 2008
PubMed ID: 18691323
Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation.
Chiu YJ, McBeath E, Fujiwara K
J Cell Biol. 2008
PubMed ID: 18710921
Differential requirement for the SAP-Fyn interaction during NK T cell development and function.
Nunez-Cruz S, Yeo WC, Rothman J, Ojha P, Bassiri H, Juntilla M, Davidson D, Veillette A, Koretzky GA, Nichols KE
J Immunol. 2008
PubMed ID: 18684920
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X
Blood. 2008
PubMed ID: 18550847
Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn.
Miyamoto Y, Yamauchi J, Tanoue A
J Neurosci. 2008
PubMed ID: 18701695
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.
Jin H, Lanning NJ, Carter-Su C
Mol Endocrinol. 2008
PubMed ID: 18499741
Myricetin suppresses UVB-induced skin cancer by targeting Fyn.
Jung SK, Lee KW, Byun S, Kang NJ, Lim SH, Heo YS, Bode AM, Bowden GT, Lee HJ, Dong Z
Cancer Res. 2008
PubMed ID: 18632659
Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity.
Zhong MC, Veillette A
J Biol Chem. 2008
PubMed ID: 18482989
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Tang X, Jang SW, Okada M, Chan CB, Feng Y, Liu Y, Luo SW, Hong Y, Rama N, Xiong WC, Mehlen P, Ye K
Nat Cell Biol. 2008
PubMed ID: 18469807
Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development.
Goto J, Tezuka T, Nakazawa T, Sagara H, Yamamoto T
Mol Cell Neurosci. 2008
PubMed ID: 18403215
Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules.
White R, Gonsior C, Krämer-Albers EM, Stöhr N, Hüttelmaier S, Trotter J
J Cell Biol. 2008
PubMed ID: 18490510
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
Reddy KB, Smith DM, Plow EF
J Cell Sci. 2008
PubMed ID: 18430780
Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism.
Williamson R, Usardi A, Hanger DP, Anderton BH
FASEB J. 2008
PubMed ID: 18096814
Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S
J Biol Chem. 2008
PubMed ID: 18258597
Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.
Brackenbury WJ, Davis TH, Chen C, Slat EA, Detrow MJ, Dickendesher TL, Ranscht B, Isom LL
J Neurosci. 2008
PubMed ID: 18354028
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration.
Dey N, Crosswell HE, De P, Parsons R, Peng Q, Su JD, Durden DL
Cancer Res. 2008
PubMed ID: 18339867
Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
Hoe HS, Minami SS, Makarova A, Lee J, Hyman BT, Matsuoka Y, Rebeck GW
J Biol Chem. 2008
PubMed ID: 18089558
TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.
Samarakoon R, Higgins SP, Higgins CE, Higgins PJ
J Mol Cell Cardiol. 2008
PubMed ID: 18255094
BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia.
Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB, Chandra J
Blood. 2008
PubMed ID: 18180382
Fyn is a novel target of (-)-epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation.
He Z, Tang F, Ermakova S, Li M, Zhao Q, Cho YY, Ma WY, Choi HS, Bode AM, Yang CS, Dong Z
Mol Carcinog. 2008
PubMed ID: 18095272
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
Regulation of FynT function by dual domain docking on PAG/Cbp.
Solheim SA, Torgersen KM, Taskén K, Berge T
J Biol Chem. 2008
PubMed ID: 18056706
Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer.
Sørensen KD, Borre M, Ørntoft TF, Dyrskjøt L, Tørring N
Int J Cancer. 2008
PubMed ID: 17943724
Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTP alpha.
Ye H, Tan YL, Ponniah S, Takeda Y, Wang SQ, Schachner M, Watanabe K, Pallen CJ, Xiao ZC
EMBO J. 2008
PubMed ID: 18046458
Quantifying information transfer by protein domains: analysis of the Fyn SH2 domain structure.
Lenaerts T, Ferkinghoff-Borg J, Stricher F, Serrano L, Schymkowitz JW, Rousseau F
BMC Struct Biol. 2008
PubMed ID: 18842137
Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.
Li Y, Rowland C, Xiromerisiou G, Lagier RJ, Schrodi SJ, Dradiotis E, Ross D, Bui N, Catanese J, Aggelakis K, Grupe A, Hadjigeorgiou G
PLoS ONE. 2008
PubMed ID: 18628988
The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly.
Pires de Miranda M, Alenquer M, Marques S, Rodrigues L, Lopes F, Bustelo XR, Simas JP
PLoS ONE. 2008
PubMed ID: 18301737
Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction.
Shelton H, Harris M
Virol J. 2008
PubMed ID: 18267011
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Association analysis of tyrosine kinase FYN gene polymorphisms in asthmatic children.
Szczepankiewicz A, Breborowicz A, Skibińska M, Wiłkość M, Tomaszewska M, Hauser J
Int Arch Allergy Immunol. 2008
PubMed ID: 17703099
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.
Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG
J Biol Chem. 2007
PubMed ID: 17925405
Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB
Mol Cell Biol. 2007
PubMed ID: 17923684
Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma.
Ilić V, Milosević-Jovcić N, Petrović S, Marković D, Bila J, Bosković D, Stefanović G, Marković O, Glibetić M
Ann Hematol. 2007
PubMed ID: 17701175
The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.
Li W, Sofi MH, Rietdijk S, Wang N, Terhorst C, Chang CH
Immunity. 2007
PubMed ID: 18031696
Fyn regulates the duration of TCR engagement needed for commitment to effector function.
Filby A, Seddon B, Kleczkowska J, Salmond R, Tomlinson P, Smida M, Lindquist JA, Schraven B, Zamoyska R
J Immunol. 2007
PubMed ID: 17878361
Activation of T cells by cross-linking Qa-2, the ped gene product, requires Fyn.
De Fazio SR, Warner CM
Am J Reprod Immunol. 2007
PubMed ID: 17845201
Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.
Holmes K, Roberts OL, Thomas AM, Cross MJ
Cell Signal. 2007
PubMed ID: 17658244
CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex.
Stuart LM, Bell SA, Stewart CR, Silver JM, Richard J, Goss JL, Tseng AA, Zhang A, El Khoury JB, Moore KJ
J Biol Chem. 2007
PubMed ID: 17623670
Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase.
Clarkson NG, Simmonds SJ, Puklavec MJ, Brown MH
J Biol Chem. 2007
PubMed ID: 17599905
Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development.
Hager E, Hawwari A, Matsuda JL, Krangel MS, Gapin L
J Immunol. 2007
PubMed ID: 17675483
The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.
Sandilands E, Brunton VG, Frame MC
J Cell Sci. 2007
PubMed ID: 17623777
Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway.
Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R
J Immunol. 2007
PubMed ID: 17579091
A novel role for Fyn: change in sphere formation ability in murine embryonic stem cells.
Makinodan E, Manabe T, Makinodan M, Yamauchi T, Matsuyoshi H, Sakumura R, Tatsumi K, Wanaka A
Neuroscience. 2007
PubMed ID: 17521824
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
PubMed ID: 17474147
Localized activation of Src-family protein kinases in the mouse egg.
McGinnis LK, Albertini DF, Kinsey WH
Dev Biol. 2007
PubMed ID: 17449027
Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia.
Rybakowski JK, Borkowska A, Skibinska M, Hauser J
Psychiatr Genet. 2007
PubMed ID: 17417065
Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL.
Yip YP, Kronstadt-O'Brien P, Capriotti C, Cooper JA, Yip JW
J Comp Neurol. 2007
PubMed ID: 17394141
The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts.
Pereira DB, Chao MV
J Neurosci. 2007
PubMed ID: 17475794
Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn.
Bastie CC, Zong H, Xu J, Busa B, Judex S, Kurland IJ, Pessin JE
Cell Metab. 2007
PubMed ID: 17488639
Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.
Samayawardhena LA, Kapur R, Craig AW
Blood. 2007
PubMed ID: 17213284
Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.
Bjarnadottir M, Misner DL, Haverfield-Gross S, Bruun S, Helgason VG, Stefansson H, Sigmundsson A, Firth DR, Nielsen B, Stefansdottir R, Novak TJ, Stefansson K, Gurney ME, Andresson T
J Neurosci. 2007
PubMed ID: 17460065
Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals.
Yamada Y, Ando F, Shimokata H
Int J Mol Med. 2007
PubMed ID: 17334644
Restoration of FcRgamma/Fyn signaling repairs central nervous system demyelination.
Seiwa C, Yamamoto M, Tanaka K, Fukutake M, Ueki T, Takeda S, Sakai R, Ishige A, Watanabe K, Akita M, Yagi T, Tanaka K, Asou H
J Neurosci Res. 2007
PubMed ID: 17290413
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Jiang Y, Cheng H
Leuk Res. 2007
PubMed ID: 16938345
Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior.
Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, Janak PH, Lovinger DM, Ron D
J Neurosci. 2007
PubMed ID: 17392475
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.
Davidson D, Schraven B, Veillette A
Mol Cell Biol. 2007
PubMed ID: 17210649
Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.
Castaño J, Solanas G, Casagolda D, Raurell I, Villagrasa P, Bustelo XR, García de Herreros A, Duñach M
Mol Cell Biol. 2007
PubMed ID: 17194753
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn.
Yun HM, Kim S, Kim HJ, Kostenis E, Kim JI, Seong JY, Baik JH, Rhim H
J Biol Chem. 2007
PubMed ID: 17189269
Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition.
Frossi B, Rivera J, Hirsch E, Pucillo C
J Immunol. 2007
PubMed ID: 17277164
A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties.
Grabulovski D, Kaspar M, Neri D
J Biol Chem. 2007
PubMed ID: 17130124
Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell survival.
Tang X, Feng Y, Ye K
Cell Death Differ. 2007
PubMed ID: 16841086
SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase.
McCausland MM, Yusuf I, Tran H, Ono N, Yanagi Y, Crotty S
J Immunol. 2007
PubMed ID: 17202343
Srcasm corrects Fyn-induced epidermal hyperplasia by kinase down-regulation.
Li W, Marshall C, Mei L, Gelfand J, Seykora JT
J Biol Chem. 2007
PubMed ID: 17046829
Cellular prion protein modulates the intracellular calcium response to hydrogen peroxide.
Krebs B, Wiebelitz A, Balitzki-Korte B, Vassallo N, Paluch S, Mitteregger G, Onodera T, Kretzschmar HA, Herms J
J Neurochem. 2007
PubMed ID: 17241158
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.
Zuccato E, Blott EJ, Holt O, Sigismund S, Shaw M, Bossi G, Griffiths GM
J Cell Sci. 2007
PubMed ID: 17164290
Force sensing by mechanical extension of the Src family kinase substrate p130Cas.
Sawada Y, Tamada M, Dubin-Thaler BJ, Cherniavskaya O, Sakai R, Tanaka S, Sheetz MP
Cell. 2006
PubMed ID: 17129785
TNF-alpha increases tyrosine phosphorylation of vascular endothelial cadherin and opens the paracellular pathway through fyn activation in human lung endothelia.
Angelini DJ, Hyun SW, Grigoryev DN, Garg P, Gong P, Singh IS, Passaniti A, Hasday JD, Goldblum SE
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16891393
ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKCzeta-controlled ERK1/2 activity within the nucleus.
Godeny MD, Sayeski PP
Am J Physiol Cell Physiol. 2006
PubMed ID: 16723512
Brain-derived neurotrophic factor rapidly increases NMDA receptor channel activity through Fyn-mediated phosphorylation.
Xu F, Plummer MR, Len GW, Nakazawa T, Yamamoto T, Black IB, Wu K
Brain Res. 2006
PubMed ID: 17045972
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
Lamalice L, Houle F, Huot J
J Biol Chem. 2006
PubMed ID: 16966330
Phosphorylation at Tyr-694 of Nogo-A by Src-family kinases.
Yokoyama K, Tezuka T, Hoshina N, Nakazawa T, Yamamoto T
Biochem Biophys Res Commun. 2006
PubMed ID: 16979591
Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.
Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R
Mol Cell Biol. 2006
PubMed ID: 16966372
Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation.
Laplante P, Raymond MA, Labelle A, Abe J, Iozzo RV, Hébert MJ
J Biol Chem. 2006
PubMed ID: 16882656
Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN.
Löwenberg M, Verhaar AP, Bilderbeek J, Marle J, Buttgereit F, Peppelenbosch MP, van Deventer SJ, Hommes DW
EMBO Rep. 2006
PubMed ID: 16888650
Critical roles of Src family tyrosine kinases in excitatory neuronal differentiation of cultured embryonic stem cells.
Theus MH, Wei L, Francis K, Yu SP
Exp Cell Res. 2006
PubMed ID: 16859680
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V
Biochem Biophys Res Commun. 2006
PubMed ID: 16899217
Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells.
Tan AH, Wong SC, Lam KP
J Biol Chem. 2006
PubMed ID: 16880206
Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.
Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F
J Biol Chem. 2006
PubMed ID: 16831868
A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling.
Rajagopal R, Chao MV
Mol Cell Neurosci. 2006
PubMed ID: 16860569
Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor.
Samayawardhena LA, Hu J, Stein PL, Craig AW
Cell Signal. 2006
PubMed ID: 16442778
Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP.
Liu H, Nakazawa T, Tezuka T, Yamamoto T
J Biol Chem. 2006
PubMed ID: 16777849
Structure of human Fyn kinase domain complexed with staurosporine.
Kinoshita T, Matsubara M, Ishiguro H, Okita K, Tada T
Biochem Biophys Res Commun. 2006
PubMed ID: 16782058
Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor.
Chen R, Latour S, Shi X, Veillette A
Mol Cell Biol. 2006
PubMed ID: 16847311
Muscarinic M2 receptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases.
Stirnweiss J, Valkova C, Ziesché E, Drube S, Liebmann C
Cell Signal. 2006
PubMed ID: 16337776
Fyn-induced phosphorylation of beta-adducin at tyrosine 489 and its role in their subcellular localization.
Gotoh H, Okumura N, Yagi T, Okumura A, Shima T, Nagai K
Biochem Biophys Res Commun. 2006
PubMed ID: 16765915
Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.
Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R
J Immunol. 2006
PubMed ID: 16818765
The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons.
Huang J, Sakai R, Furuichi T
Mol Biol Cell. 2006
PubMed ID: 16687575
Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.
Sulimenko V, Dráberová E, Sulimenko T, Macurek L, Richterová V, Dráber P, Dráber P
J Immunol. 2006
PubMed ID: 16751367
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.
Cannons JL, Yu LJ, Jankovic D, Crotty S, Horai R, Kirby M, Anderson S, Cheever AW, Sher A, Schwartzberg PL
J Exp Med. 2006
PubMed ID: 16754717
Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
Mason LH, Willette-Brown J, Taylor LS, McVicar DW
J Immunol. 2006
PubMed ID: 16709819
Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge.
Kostic A, Sheetz MP
Mol Biol Cell. 2006
PubMed ID: 16597701
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.
Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS
J Clin Invest. 2006
PubMed ID: 16628251
FAK-dependent regulation of myofibroblast differentiation.
Greenberg RS, Bernstein AM, Benezra M, Gelman IH, Taliana L, Masur SK
FASEB J. 2006
PubMed ID: 16585062
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.
Martín-Cófreces NB, Sancho D, Fernández E, Vicente-Manzanares M, Gordón-Alonso M, Montoya MC, Michel F, Acuto O, Alarcón B, Sánchez-Madrid F
J Immunol. 2006
PubMed ID: 16547257
Fyn is required for haloperidol-induced catalepsy in mice.
Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, Kohsaka S, Yagi T, Yuasa S
J Biol Chem. 2006
PubMed ID: 16407246
Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling.
Morita A, Yamashita N, Sasaki Y, Uchida Y, Nakajima O, Nakamura F, Yagi T, Taniguchi M, Usui H, Katoh-Semba R, Takei K, Goshima Y
J Neurosci. 2006
PubMed ID: 16540575
Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.
Okabe S, Tauchi T, Ohyashiki K, Broxmeyer HE
Blood Cells Mol Dis. 2006
PubMed ID: 16503409
NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice.
Isosaka T, Hattori K, Yagi T
Brain Res. 2006
PubMed ID: 16438943
Altered gene expression in the subdivisions of the amygdala of Fyn-deficient mice as revealed by laser capture microdissection and mKIAA cDNA array analysis.
Kai N, Iwase K, Imai K, Nakahira E, Soma M, Ohtsuka S, Yagi T, Kobayashi K, Koga H, Takiguchi M, Yuasa S
Brain Res. 2006
PubMed ID: 16427614
Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI.
Yu M, Lowell CA, Neel BG, Gu H
J Immunol. 2006
PubMed ID: 16456001
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses.
Olivera A, Urtz N, Mizugishi K, Yamashita Y, Gilfillan AM, Furumoto Y, Gu H, Proia RL, Baumruker T, Rivera J
J Biol Chem. 2006
PubMed ID: 16316995
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.
Kärkkäinen S, Hiipakka M, Wang JH, Kleino I, Vähä-Jaakkola M, Renkema GH, Liss M, Wagner R, Saksela K
EMBO Rep. 2006
PubMed ID: 16374509
Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation.
Yang C, Zhou W, Jeon MS, Demydenko D, Harada Y, Zhou H, Liu YC
Mol Cell. 2006
PubMed ID: 16387660
Modelling thymic HIV-1 Nef effects.
Stove V, Verhasselt B
Curr HIV Res. 2006
PubMed ID: 16454711
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Protein tyrosine phosphatase alpha regulates Fyn activity and Cbp/PAG phosphorylation in thymocyte lipid rafts.
Maksumova L, Le HT, Muratkhodjaev F, Davidson D, Veillette A, Pallen CJ
J Immunol. 2005
PubMed ID: 16339530
Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src.
Macdonald DS, Weerapura M, Beazely MA, Martin L, Czerwinski W, Roder JC, Orser BA, MacDonald JF
J Neurosci. 2005
PubMed ID: 16339032
Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells.
Gomez G, Gonzalez-Espinosa C, Odom S, Baez G, Cid ME, Ryan JJ, Rivera J
J Immunol. 2005
PubMed ID: 16301670
CD1d-independent developmental acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with complementarity determining region 3-diverse and biased Vbeta2/Vbeta7/Vbeta8/Valpha3.2 T cell receptor usage.
Chen YT, Kung JT
J Immunol. 2005
PubMed ID: 16272308
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
Roskoski R
Biochem Biophys Res Commun. 2005
PubMed ID: 16129412
Requirement of SRC-family tyrosine kinases in fat accumulation.
Sun Y, Ma YC, Huang J, Chen KY, McGarrigle DK, Huang XY
Biochemistry. 2005
PubMed ID: 16262245
Disease-related modifications in tau affect the interaction between Fyn and Tau.
Bhaskar K, Yen SH, Lee G
J Biol Chem. 2005
PubMed ID: 16115884
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L
J Neurosci. 2005
PubMed ID: 16237174
Disruption of the actin network enhances MAP-2c and Fyn-induced process outgrowth.
Zamora-Leon SP, Shafit-Zagardo B
Cell Motil Cytoskeleton. 2005
PubMed ID: 16145685
Absence of Fyn and Src causes a reeler-like phenotype.
Kuo G, Arnaud L, Kronstad-O'Brien P, Cooper JA
J Neurosci. 2005
PubMed ID: 16162939
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
Abe T, Matsumura S, Katano T, Mabuchi T, Takagi K, Xu L, Yamamoto A, Hattori K, Yagi T, Watanabe M, Nakazawa T, Yamamoto T, Mishina M, Nakai Y, Ito S
Eur J Neurosci. 2005
PubMed ID: 16190898
Evidence for involvement of p59fyn in fasting-induced thymic involution.
Nishio H, Takase I, Fukunishi S, Takagi T, Tamura A, Miyazaki T, Suzuki K
Scand J Immunol. 2005
PubMed ID: 16101815
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase.
Derkinderen P, Scales TM, Hanger DP, Leung KY, Byers HL, Ward MA, Lenz C, Price C, Bird IN, Perera T, Kellie S, Williamson R, Noble W, Van Etten RA, Leroy K, Brion JP, Reynolds CH, Anderton BH
J Neurosci. 2005
PubMed ID: 16014719
Fyn is a downstream target of the pleiotrophin/receptor protein tyrosine phosphatase beta/zeta-signaling pathway: regulation of tyrosine phosphorylation of Fyn by pleiotrophin.
Pariser H, Ezquerra L, Herradon G, Perez-Pinera P, Deuel TF
Biochem Biophys Res Commun. 2005
PubMed ID: 15925565
Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.
Nishida K, Yamasaki S, Ito Y, Kabu K, Hattori K, Tezuka T, Nishizumi H, Kitamura D, Goitsuka R, Geha RS, Yamamoto T, Yagi T, Hirano T
J Cell Biol. 2005
PubMed ID: 15998803
Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.
Bloch-Queyrat C, Fondanèche MC, Chen R, Yin L, Relouzat F, Veillette A, Fischer A, Latour S
J Exp Med. 2005
PubMed ID: 15998796
Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.
Xie Z, Singleton PA, Bourguignon LY, Bikle DD
Mol Biol Cell. 2005
PubMed ID: 15872086
Mice lacking the IFN-gamma receptor or fyn develop severe experimental autoimmune uveoretinitis characterized by different immune responses.
Fukushima A, Yamaguchi T, Ishida W, Fukata K, Udaka K, Ueno H
Immunogenetics. 2005
PubMed ID: 15902435
Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role.
Ho GJ, Hashimoto M, Adame A, Izu M, Alford MF, Thal LJ, Hansen LA, Masliah E
Neurobiol Aging. 2005
PubMed ID: 15708437
Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth.
Santuccione A, Sytnyk V, Leshchyns'ka I, Schachner M
J Cell Biol. 2005
PubMed ID: 15851519
Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell CA, Kawakami T
J Immunol. 2005
PubMed ID: 15814670
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ, Ashwell JD
Nat Immunol. 2005
PubMed ID: 15735648
Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo.
Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaeus RC
Circ Res. 2005
PubMed ID: 15731459
Interactions of TOM1L1 with the multivesicular body sorting machinery.
Puertollano R
J Biol Chem. 2005
PubMed ID: 15611048
Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product.
Pasquier B, Yin L, Fondanèche MC, Relouzat F, Bloch-Queyrat C, Lambert N, Fischer A, de Saint-Basile G, Latour S
J Exp Med. 2005
PubMed ID: 15738056
Impairment of conditioned freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function.
Kojima N, Sakamoto T, Endo S, Niki H
Eur J Neurosci. 2005
PubMed ID: 15813945
Pigment epithelium-derived factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn.
Kanda S, Mochizuki Y, Nakamura T, Miyata Y, Matsuyama T, Kanetake H
J Cell Sci. 2005
PubMed ID: 15713745
Regulation of NKT cell development by SAP, the protein defective in XLP.
Nichols KE, Hom J, Gong SY, Ganguly A, Ma CS, Cannons JL, Tangye SG, Schwartzberg PL, Koretzky GA, Stein PL
Nat Med. 2005
PubMed ID: 15711562
Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen.
Kohno M, Yamasaki S, Tybulewicz VL, Saito T
Blood. 2005
PubMed ID: 15542585
Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling.
Paccani SR, Patrussi L, Ulivieri C, Masferrer JL, D'Elios MM, Baldari CT
Blood. 2005
PubMed ID: 15514010
Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor.
Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N
J Neurosci. 2005
PubMed ID: 15716419
Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability.
Criscuoli ML, Nguyen M, Eliceiri BP
Blood. 2005
PubMed ID: 15486073
The adaptor protein 3BP2 associates with VAV guanine nucleotide exchange factors to regulate NFAT activation by the B-cell antigen receptor.
Foucault I, Le Bras S, Charvet C, Moon C, Altman A, Deckert M
Blood. 2005
PubMed ID: 15345594
Regulation of ultraviolet B-induced phosphorylation of histone H3 at serine 10 by Fyn kinase.
He Z, Cho YY, Ma WY, Choi HS, Bode AM, Dong Z
J Biol Chem. 2005
PubMed ID: 15537652
Fyn phosphorylates human MAP-2c on tyrosine 67.
Zamora-Leon SP, Bresnick A, Backer JM, Shafit-Zagardo B
J Biol Chem. 2005
PubMed ID: 15536091
Stromal cell-derived factor-1alpha/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1.
Okabe S, Fukuda S, Kim YJ, Niki M, Pelus LM, Ohyashiki K, Pandolfi PP, Broxmeyer HE
Blood. 2005
PubMed ID: 15345598
Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation.
Lu Z, Ku L, Chen Y, Feng Y
J Biol Chem. 2005
PubMed ID: 15528192
RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation.
Bodrikov V, Leshchyns'ka I, Sytnyk V, Overvoorde J, den Hertog J, Schachner M
J Cell Biol. 2005
PubMed ID: 15623578
Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events.
Werdich XQ, Penn JS
Angiogenesis. 2005
PubMed ID: 16400523
Nef: "necessary and enforcing factor" in HIV infection.
Joseph AM, Kumar M, Mitra D
Curr HIV Res. 2005
PubMed ID: 15638726
Characterization of the interactions of the nephrin intracellular domain.
Liu XL, Kilpeläinen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, Pikkarainen T, Yan K, Jonsson AP, Tryggvason K
FEBS J. 2005
PubMed ID: 15634346
Substrate-trapping techniques in the identification of cellular PTP targets.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML
Methods. 2005
PubMed ID: 15588985
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin.
Li H, Lemay S, Aoudjit L, Kawachi H, Takano T
J Am Soc Nephrol. 2004
PubMed ID: 15579503
Development of CD1d-restricted NKT cells in the mouse thymus.
Dao T, Guo D, Ploss A, Stolzer A, Saylor C, Boursalian TE, Im JS, Sant'Angelo DB
Eur J Immunol. 2004
PubMed ID: 15549774
Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidance.
Meriane M, Tcherkezian J, Webber CA, Danek EI, Triki I, McFarlane S, Bloch-Gallego E, Lamarche-Vane N
J Cell Biol. 2004
PubMed ID: 15557120
RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction.
McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D
J Neurosci. 2004
PubMed ID: 15548669
Auditory-conditioned-fear-dependent c-Fos expression is altered in the emotion-related brain structures of Fyn-deficient mice.
Kubota O, Hattori K, Hashimoto K, Yagi T, Sato T, Iyo M, Yuasa S
Brain Res Mol Brain Res. 2004
PubMed ID: 15519685
Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.
Davidson D, Shi X, Zhang S, Wang H, Nemer M, Ono N, Ohno S, Yanagi Y, Veillette A
Immunity. 2004
PubMed ID: 15539156
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1.
Cannons JL, Yu LJ, Hill B, Mijares LA, Dombroski D, Nichols KE, Antonellis A, Koretzky GA, Gardner K, Schwartzberg PL
Immunity. 2004
PubMed ID: 15539155
Activation of FAK and Src are receptor-proximal events required for netrin signaling.
Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL
Nat Neurosci. 2004
PubMed ID: 15494734
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction.
Liu G, Beggs H, Jürgensen C, Park HT, Tang H, Gorski J, Jones KR, Reichardt LF, Wu J, Rao Y
Nat Neurosci. 2004
PubMed ID: 15494732
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W
J Exp Med. 2004
PubMed ID: 15477350
Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling.
Sugie K, Jeon MS, Grey HM
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15465914
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study.
Loers G, Aboul-Enein F, Bartsch U, Lassmann H, Schachner M
Mol Cell Neurosci. 2004
PubMed ID: 15485773
PKC-interacting proteins: from function to pharmacology.
Poole AW, Pula G, Hers I, Crosby D, Jones ML
Trends Pharmacol Sci. 2004
PubMed ID: 15380937
Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.
Kaabeche K, Lemonnier J, Le Mée S, Caverzasio J, Marie PJ
J Biol Chem. 2004
PubMed ID: 15190072
Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase.
Ghosh AK, Reddi AL, Rao NL, Duan L, Band V, Band H
J Biol Chem. 2004
PubMed ID: 15208330
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr.
Choi WS, Hiragun T, Lee JH, Kim YM, Kim HP, Chahdi A, Her E, Han JW, Beaven MA
Mol Cell Biol. 2004
PubMed ID: 15282299
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.
Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S
Hum Mol Genet. 2004
PubMed ID: 15175272
Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E.
Li C, Sasaki Y, Takei K, Yamamoto H, Shouji M, Sugiyama Y, Kawakami T, Nakamura F, Yagi T, Ohshima T, Goshima Y
J Neurosci. 2004
PubMed ID: 15240808
Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation.
Phillips N, Hayward RD, Koronakis V
Nat Cell Biol. 2004
PubMed ID: 15220932
Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells.
Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM
J Immunol. 2004
PubMed ID: 15210764
Tyrosine phosphorylation of calponins. Inhibition of the interaction with F-actin.
Abouzaglou J, Bénistant C, Gimona M, Roustan C, Kassab R, Fattoum A
Eur J Biochem. 2004
PubMed ID: 15206927
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny.
Gadue P, Yin L, Jain S, Stein PL
J Immunol. 2004
PubMed ID: 15128794
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L
J Neurosci. 2004
PubMed ID: 15140940
Regulation of TRPC6 channel activity by tyrosine phosphorylation.
Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K
J Biol Chem. 2004
PubMed ID: 14761972
No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.
Watanabe T, Ohnuma T, Shibata N, Ohtsuka M, Ueki A, Nagao M, Arai H
Neurosci Lett. 2004
PubMed ID: 15082191
Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353.
Cui J, Matkovich SJ, deSouza N, Li S, Rosemblit N, Marks AR
J Biol Chem. 2004
PubMed ID: 14761954
Defective neocortical development in Fyn-tyrosine-kinase-deficient mice.
Yuasa S, Hattori K, Yagi T
Neuroreport. 2004
PubMed ID: 15073522
HIV/SIV escape from immune surveillance: focus on Nef.
Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M
Curr HIV Res. 2004
PubMed ID: 15078178
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta.
Filipp D, Leung BL, Zhang J, Veillette A, Julius M
J Immunol. 2004
PubMed ID: 15034040
Protein tyrosine phosphatase epsilon activates Yes and Fyn in Neu-induced mammary tumor cells.
Granot-Attas S, Elson A
Exp Cell Res. 2004
PubMed ID: 14980517
Phosphorylation of tau by fyn: implications for Alzheimer's disease.
Lee G, Thangavel R, Sharma VM, Litersky JM, Bhaskar K, Fang SM, Do LH, Andreadis A, Van Hoesen G, Ksiezak-Reding H
J Neurosci. 2004
PubMed ID: 14999081
Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice.
Hamaguchi-Hamada K, Sanbo C, Hamada S, Yagi T
Neurosci Res. 2004
PubMed ID: 15154672
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
Macdonald A, Crowder K, Street A, McCormick C, Harris M
J Gen Virol. 2004
PubMed ID: 14993658
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
Gorska MM, Stafford SJ, Cen O, Sur S, Alam R
J Exp Med. 2004
PubMed ID: 14757743
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
[Analysis of the fyn kinase gene in Alzheimer's disease and schizophrenia]
Nakano Y, Akahane A, Tanaka H, Ueno M, Kunugi H, Nanko S
No To Shinkei. 2004
PubMed ID: 15098360
Altered gene expression in the adult brain of fyn-deficient mice.
Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T
Cell Mol Neurobiol. 2004
PubMed ID: 15049519
Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.
Leavitt SA, SchOn A, Klein JC, Manjappara U, Chaiken IM, Freire E
Curr Protein Pept Sci. 2004
PubMed ID: 14965316
Immunoseparation of Prion protein-enriched domains from other detergent-resistant membrane fractions, isolated from neuronal cells.
Botto L, Masserini M, Cassetti A, Palestini P
FEBS Lett. 2004
PubMed ID: 14741357
E2A proteins enforce a proliferation checkpoint in developing thymocytes.
Engel I, Murre C
EMBO J. 2004
PubMed ID: 14685278
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA
J Exp Med. 2004
PubMed ID: 14707117
Unchanged scrapie pathology in brain tissue of tyrosine kinase Fyn-deficient mice.
Schwarz A, Burwinkel M, Riemer C, Schultz J, Baier M
Neurodegener Dis. 2004
PubMed ID: 16908977
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
The dual response of protein kinase Fyn to neural trauma: early induction in neurons and delayed induction in reactive astrocytes.
Chun JT, Crispino M, Tocco G
Exp Neurol. 2004
PubMed ID: 14697322
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.
Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, Santos R, Schadt EE, Stoughton R, Shoemaker DD
Science. 2003
PubMed ID: 14684825
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts.
Schumann G, Rujescu D, Kissling C, Soyka M, Dahmen N, Preuss UW, Wieman S, Depner M, Wellek S, Lascorz J, Bondy B, Giegling I, Anghelescu I, Cowen MS, Poustka A, Spanagel R, Mann K, Henn FA, Szegedi A
Biol Psychiatry. 2003
PubMed ID: 14675807
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI
Dev Biol. 2003
PubMed ID: 14651920
Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts.
Shima T, Nada S, Okada M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14645715
Identification and activation of Src family kinases in primary megakaryocytes.
Lannutti BJ, Shim MH, Blake N, Reems JA, Drachman JG
Exp Hematol. 2003
PubMed ID: 14662334
Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury.
Kotadia BK, Ravindranath TM, Choudhry MA, Haque F, Al-Ghoul W, Sayeed MM
Shock. 2003
PubMed ID: 14625475
Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck.
Yokoyama N, Miller WT
J Biol Chem. 2003
PubMed ID: 14506255
Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn.
Nada S, Shima T, Yanai H, Husi H, Grant SG, Okada M, Akiyama T
J Biol Chem. 2003
PubMed ID: 13129934
Cooperative roles of Fyn and cortactin in cell migration of metastatic murine melanoma.
Huang J, Asawa T, Takato T, Sakai R
J Biol Chem. 2003
PubMed ID: 13129922
Tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCgamma1 and Sam68.
Paronetto MP, Venables JP, Elliott DJ, Geremia R, Rossi P, Sette C
Oncogene. 2003
PubMed ID: 14647465
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1.
Sanguinetti AR, Cao H, Corley Mastick C
Biochem J. 2003
PubMed ID: 12921535
Alphavbeta6-Fyn signaling promotes oral cancer progression.
Li X, Yang Y, Hu Y, Dang D, Regezi J, Schmidt BL, Atakilit A, Chen B, Ellis D, Ramos DM
J Biol Chem. 2003
PubMed ID: 12917446
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases.
Ballif BA, Arnaud L, Cooper JA
Brain Res Mol Brain Res. 2003
PubMed ID: 14559149
Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.
Bock HH, Jossin Y, Liu P, Förster E, May P, Goffinet AM, Herz J
J Biol Chem. 2003
PubMed ID: 12882964
Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.
Miravet S, Piedra J, Castaño J, Raurell I, Francí C, Duñach M, García de Herreros A
Mol Cell Biol. 2003
PubMed ID: 14517306
Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia.
Ma J, Zhang GY
Neurosci Lett. 2003
PubMed ID: 12932824
Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases.
Lahdenperä J, Kilpeläinen P, Liu XL, Pikkarainen T, Reponen P, Ruotsalainen V, Tryggvason K
Kidney Int. 2003
PubMed ID: 12846735
Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.
Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE
J Biol Chem. 2003
PubMed ID: 12730241
Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho.
Martinez MC, Ochiishi T, Majewski M, Kosik KS
J Cell Biol. 2003
PubMed ID: 12835311
p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.
Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T
Mol Biol Cell. 2003
PubMed ID: 12857875
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells.
Seddon B, Tomlinson P, Zamoyska R
Nat Immunol. 2003
PubMed ID: 12808452
H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity.
Thornton C, Yaka R, Dinh S, Ron D
J Biol Chem. 2003
PubMed ID: 12695509
p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.
Taniguchi S, Liu H, Nakazawa T, Yokoyama K, Tezuka T, Yamamoto T
Biochem Biophys Res Commun. 2003
PubMed ID: 12788081
Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin.
Verma R, Wharram B, Kovari I, Kunkel R, Nihalani D, Wary KK, Wiggins RC, Killen P, Holzman LB
J Biol Chem. 2003
PubMed ID: 12668668
Reelin and brain development.
Tissir F, Goffinet AM
Nat Rev Neurosci. 2003
PubMed ID: 12778121
Regulation of Fyn through translocation of activated Lck into lipid rafts.
Filipp D, Zhang J, Leung BL, Shaw A, Levin SD, Veillette A, Julius M
J Exp Med. 2003
PubMed ID: 12732664
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation.
Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C
Immunity. 2003
PubMed ID: 12753742
Scaffolding of Fyn kinase to the NMDA receptor determines brain region sensitivity to ethanol.
Yaka R, Phamluong K, Ron D
J Neurosci. 2003
PubMed ID: 12736333
Transmodulation between phospholipase D and c-Src enhances cell proliferation.
Ahn BH, Kim SY, Kim EH, Choi KS, Kwon TK, Lee YH, Chang JS, Kim MS, Jo YH, Min DS
Mol Cell Biol. 2003
PubMed ID: 12697812
Expression of Fyn, a non-receptor tyrosine kinase in prefrontal cortex from patients with schizophrenia and its correlation with clinical onset.
Ohnuma T, Kato H, Arai H, McKenna PJ, Emson PC
Brain Res Mol Brain Res. 2003
PubMed ID: 12670706
The role of PI3K in immune cells.
Koyasu S
Nat Immunol. 2003
PubMed ID: 12660731
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.
Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M
Mol Cell Biol. 2003
PubMed ID: 12640114
Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress.
Xu H, Zhao H, Tian W, Yoshida K, Roullet JB, Cohen DM
J Biol Chem. 2003
PubMed ID: 12538589
Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1.
Yaka R, He DY, Phamluong K, Ron D
J Biol Chem. 2003
PubMed ID: 12524444
Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia.
Chen M, Hou X, Zhang G
Neurosci Lett. 2003
PubMed ID: 12618293
Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development.
Saijo K, Schmedt C, Su IH, Karasuyama H, Lowell CA, Reth M, Adachi T, Patke A, Santana A, Tarakhovsky A
Nat Immunol. 2003
PubMed ID: 12563261
Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.
Li C, Iosef C, Jia CY, Han VK, Li SS
J Biol Chem. 2003
PubMed ID: 12458214
Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck.
Niu S, Xie H, Marcantonio EE
Mol Biol Cell. 2003
PubMed ID: 12589038
SAP couples Fyn to SLAM immune receptors.
Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ
Nat Cell Biol. 2003
PubMed ID: 12545174
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation.
Latour S, Roncagalli R, Chen R, Bakinowski M, Shi X, Schwartzberg PL, Davidson D, Veillette A
Nat Cell Biol. 2003
PubMed ID: 12545173
Reelin activates SRC family tyrosine kinases in neurons.
Bock HH, Herz J
Curr Biol. 2003
PubMed ID: 12526740
Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development.
Arnaud L, Ballif BA, Förster E, Cooper JA
Curr Biol. 2003
PubMed ID: 12526739
Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.
Messina S, Onofri F, Bongiorno-Borbone L, Giovedì S, Valtorta F, Girault JA, Benfenati F
J Neurochem. 2003
PubMed ID: 12558988
Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.
Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Béliveau R
Mol Biol Cell. 2003
PubMed ID: 12529448
Src kinase becomes preferentially associated with the VEGFR, KDR/Flk-1, following VEGF stimulation of vascular endothelial cells.
Chou MT, Wang J, Fujita DJ
BMC Biochem. 2002
PubMed ID: 12509223
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Defective thymocyte maturation by transgenic expression of a truncated form of the T lymphocyte adapter molecule and Fyn substrate, Sin.
Donlin LT, Roman CA, Adlam M, Regelmann AG, Alexandropoulos K
J Immunol. 2002
PubMed ID: 12471123
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.
Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW
J Biol Chem. 2002
PubMed ID: 12239221
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.
Tsujikawa K, Ichijo T, Moriyama K, Tadotsu N, Sakamoto K, Sakane N, Fukada S, Furukawa T, Saito H, Yamamoto H
Mol Cancer Res. 2002
PubMed ID: 12496362
Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).
Ko BC, Lam AK, Kapus A, Fan L, Chung SK, Chung SS
J Biol Chem. 2002
PubMed ID: 12359721
Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules.
Freund C, Kühne R, Yang H, Park S, Reinherz EL, Wagner G
EMBO J. 2002
PubMed ID: 12426371
Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia.
Hou XY, Zhang GY, Yan JZ, Chen M, Liu Y
Brain Res. 2002
PubMed ID: 12419528
Identification of an alternatively spliced isoform of the fyn tyrosine kinase.
Goldsmith JF, Hall CG, Atkinson TP
Biochem Biophys Res Commun. 2002
PubMed ID: 12408980
An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn.
Rao N, Ghosh AK, Douillard P, Andoniou CE, Zhou P, Band H
Signal Transduct. 2002
PubMed ID: 19966925
Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma.
Berwanger B, Hartmann O, Bergmann E, Bernard S, Nielsen D, Krause M, Kartal A, Flynn D, Wiedemeyer R, Schwab M, Schäfer H, Christiansen H, Eilers M
Cancer Cell. 2002
PubMed ID: 12450793
Sustained activation of N-WASP through phosphorylation is essential for neurite extension.
Suetsugu S, Hattori M, Miki H, Tezuka T, Yamamoto T, Mikoshiba K, Takenawa T
Dev Cell. 2002
PubMed ID: 12431372
SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation.
Wu L, Yu Z, Shen SH
J Biol Chem. 2002
PubMed ID: 12171928
The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.
Feuillet V, Semichon M, Restouin A, Harriague J, Janzen J, Magee A, Collette Y, Bismuth G
Oncogene. 2002
PubMed ID: 12370810
Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase.
Sette C, Paronetto MP, Barchi M, Bevilacqua A, Geremia R, Rossi P
EMBO J. 2002
PubMed ID: 12374739
P59(fyn) is upregulated in anergic CD8+ T cells.
Welke J, Zavazava N
Hum Immunol. 2002
PubMed ID: 12368035
c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination.
Taher TE, Tjin EP, Beuling EA, Borst J, Spaargaren M, Pals ST
J Immunol. 2002
PubMed ID: 12244174
Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil.
Stork O, Kojima N, Stork S, Kume N, Obata K
Brain Res Mol Brain Res. 2002
PubMed ID: 12399115
QM, a putative tumor suppressor, regulates proto-oncogene c-yes.
Oh HS, Kwon H, Sun SK, Yang CH
J Biol Chem. 2002
PubMed ID: 12138090
Phosphorylation of c-Cbl protooncogene product following ethanol administration in rat cerebellum: possible involvement of Fyn kinase.
Nishio H, Otsuka M, Kinoshita S, Tokuoka T, Nakajima M, Noda Y, Fukuyama Y, Suzuki K
Brain Res. 2002
PubMed ID: 12231245
TCR signals mediated by Src family kinases are essential for the survival of naive T cells.
Seddon B, Zamoyska R
J Immunol. 2002
PubMed ID: 12218114
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, Minaki Y, Kato A, Tani-Ichi S, Hamaoka T, Kosugi A
J Immunol. 2002
PubMed ID: 12218089
Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc.
Roccato E, Miranda C, Ranzi V, Gishizki M, Pierotti MA, Greco A
Br J Cancer. 2002
PubMed ID: 12237775
Role of NFAT and AP-1 in PGE2-mediated T cell suppression in burn injury.
Choudhry MA, Mao H, Haque F, Khan M, Fazal N, Sayeed MM
Shock. 2002
PubMed ID: 12353920
Activation of phospholipase Cgamma2 by tyrosine phosphorylation.
Ozdener F, Dangelmaier C, Ashby B, Kunapuli SP, Daniel JL
Mol Pharmacol. 2002
PubMed ID: 12181444
Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.
Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y
Neuron. 2002
PubMed ID: 12372285
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation.
Parravicini V, Gadina M, Kovarova M, Odom S, Gonzalez-Espinosa C, Furumoto Y, Saitoh S, Samelson LE, O'Shea JJ, Rivera J
Nat Immunol. 2002
PubMed ID: 12089510
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
Kassenbrock CK, Hunter S, Garl P, Johnson GL, Anderson SM
J Biol Chem. 2002
PubMed ID: 11994282
Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.
Prevost N, Woulfe D, Tanaka T, Brass LF
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12084815
CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.
Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12077322
Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.
Nguyen TH, Liu J, Lombroso PJ
J Biol Chem. 2002
PubMed ID: 11983687
Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases.
Nakamura T, Yamashita H, Nagano Y, Takahashi T, Avraham S, Avraham H, Matsumoto M, Nakamura S
FEBS Lett. 2002
PubMed ID: 12096713
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling.
Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP
J Biol Chem. 2002
PubMed ID: 11943772
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.
Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11943848
Characterization and location of Src-dependent tyrosine phosphorylation in rat brain mitochondria.
Salvi M, Brunati AM, Bordin L, La Rocca N, Clari G, Toninello A
Biochim Biophys Acta. 2002
PubMed ID: 12007793
UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug.
Oneyama C, Nakano H, Sharma SV
Oncogene. 2002
PubMed ID: 11960376
A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.
Lowin-Kropf B, Kunz B, Schneider P, Held W
Eur J Immunol. 2002
PubMed ID: 11870621
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR
J Biol Chem. 2002
PubMed ID: 11741929
Src family kinase-dependent phosphorylation of a 29-kDa caveolin-associated protein.
Newcomb LF, Mastick CC
Biochem Biophys Res Commun. 2002
PubMed ID: 11820784
Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau.
Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J
J Neurosci. 2002
PubMed ID: 11826099
Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.
Howie D, Simarro M, Sayos J, Guirado M, Sancho J, Terhorst C
Blood. 2002
PubMed ID: 11806999
Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation.
Negro A, Brunati AM, Donella-Deana A, Massimino ML, Pinna LA
FASEB J. 2002
PubMed ID: 11744621
Light-potentiation of acoustic startle response (ASR) and monoamine efflux related to fearfulness in Fyn-deficient mice.
Hironaka N, Yagi T, Niki H
Brain Res Mol Brain Res. 2002
PubMed ID: 11834300
'Srcasm: a novel Src activating and signaling molecule.
Seykora JT, Mei L, Dotto GP, Stein PL
J Biol Chem. 2002
PubMed ID: 11711534
NCAM regulates cell motility.
Prag S, Lepekhin EA, Kolkova K, Hartmann-Petersen R, Kawa A, Walmod PS, Belman V, Gallagher HC, Berezin V, Bock E, Pedersen N
J Cell Sci. 2002
PubMed ID: 11839780
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.
Calautti E, Grossi M, Mammucari C, Aoyama Y, Pirro M, Ono Y, Li J, Dotto GP
J Cell Biol. 2002
PubMed ID: 11777936
Fyn tyrosine kinase in Sertoli cells is involved in mouse spermatogenesis.
Maekawa M, Toyama Y, Yasuda M, Yagi T, Yuasa S
Biol Reprod. 2002
PubMed ID: 11751285
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
Wolf I, Jenkins BJ, Liu Y, Seiffert M, Custodio JM, Young P, Rohrschneider LR
Mol Cell Biol. 2002
PubMed ID: 11739737
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.
Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O
FEBS Lett. 2001
PubMed ID: 11741599
Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.
Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP
Biochemistry. 2001
PubMed ID: 11724572
Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21.
Chalhoub N, Benachenhou N, Vacher J
Mamm Genome. 2001
PubMed ID: 11707774
Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin.
Shima T, Okumura N, Takao T, Satomi Y, Yagi T, Okada M, Nagai K
J Biol Chem. 2001
PubMed ID: 11526103
The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
Korkaya H, Jameel S, Gupta D, Tyagi S, Kumar R, Zafrullah M, Mazumdar M, Lal SK, Xiaofang L, Sehgal D, Das SR, Sahal D
J Biol Chem. 2001
PubMed ID: 11518702
Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells.
Hu H, Rudd CE, Schneider H
Biochem Biophys Res Commun. 2001
PubMed ID: 11676481
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion.
Mariotti A, Kedeshian PA, Dans M, Curatola AM, Gagnoux-Palacios L, Giancotti FG
J Cell Biol. 2001
PubMed ID: 11684709
Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2.
Zamora-Leon SP, Lee G, Davies P, Shafit-Zagardo B
J Biol Chem. 2001
PubMed ID: 11546790
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members.
Rajala RV, Datla RS, Carlsen SA, Anderson DH, Qi Z, Wang JH, Sharma RK
Biochem Biophys Res Commun. 2001
PubMed ID: 11594778
Dual role of Fyn in the regulation of FAK+6,7 by cannabinoids in hippocampus.
Derkinderen P, Toutant M, Kadaré G, Ledent C, Parmentier M, Girault JA
J Biol Chem. 2001
PubMed ID: 11468287
Plexin signaling via off-track and rho family GTPases.
Whitford KL, Ghosh A
Neuron. 2001
PubMed ID: 11604131
Tyrosine phosphorylation of ionotropic glutamate receptors by Fyn or Src differentially modulates their susceptibility to calpain and enhances their binding to spectrin and PSD-95.
Rong Y, Lu X, Bernard A, Khrestchatisky M, Baudry M
J Neurochem. 2001
PubMed ID: 11677266
Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.
Stuermer CA, Lang DM, Kirsch F, Wiechers M, Deininger SO, Plattner H
Mol Biol Cell. 2001
PubMed ID: 11598189
Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation.
Wolf RM, Wilkes JJ, Chao MV, Resh MD
J Neurobiol. 2001
PubMed ID: 11536198
Transient tyrosine phosphorylation of human ryanodine receptor upon T cell stimulation.
Guse AH, Tsygankov AY, Weber K, Mayr GW
J Biol Chem. 2001
PubMed ID: 11466305
Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.
Liang X, Nazarian A, Erdjument-Bromage H, Bornmann W, Tempst P, Resh MD
J Biol Chem. 2001
PubMed ID: 11423543
Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset.
Tamura T, Igarashi O, Hino A, Yamane H, Aizawa S, Kato T, Nariuchi H
J Immunol. 2001
PubMed ID: 11489976
Tyrosine phosphorylation of the N-methyl-D-aspartate receptor by exogenous and postsynaptic density-associated Src-family kinases.
Cheung HH, Gurd JW
J Neurochem. 2001
PubMed ID: 11483655
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product.
Latour S, Gish G, Helgason CD, Humphries RK, Pawson T, Veillette A
Nat Immunol. 2001
PubMed ID: 11477403
Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.
Simpson A, Uitto J, Rodeck U, Mahoney MG
Gene. 2001
PubMed ID: 11483358
Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression.
Miyakawa T, Yagi T, Takao K, Niki H
Behav Brain Res. 2001
PubMed ID: 11287076
N-Methyl-D-aspartate-induced c-Fos expression is enhanced in the forebrain structures related to emotion in Fyn-deficient mice.
Hattori K, Yagi T, Maekawa M, Sato T, Yuasa S
Brain Res. 2001
PubMed ID: 11423094
Src-class kinases act within the agrin/MuSK pathway to regulate acetylcholine receptor phosphorylation, cytoskeletal anchoring, and clustering.
Mohamed AS, Rivas-Plata KA, Kraas JR, Saleh SM, Swope SL
J Neurosci. 2001
PubMed ID: 11356869
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.
Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME
J Biol Chem. 2001
PubMed ID: 11278857
Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.
Smith CL, Mittaud P, Prescott ED, Fuhrer C, Burden SJ
J Neurosci. 2001
PubMed ID: 11312300
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity.
Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A
J Biol Chem. 2001
PubMed ID: 11278378
Genetic ablation of the src kinase p59fynT exacerbates pulmonary inflammation in an allergic mouse model.
Kudlacz EM, Andresen CJ, Salafia M, Whitney CA, Naclerio B, Changelian PS
Am J Respir Cell Mol Biol. 2001
PubMed ID: 11306441
Residues Y429 and Y463 of the human CD5 are targeted by protein tyrosine kinases.
Vilà JM, Gimferrer I, Padilla O, Arman M, Places L, Simarro M, Vives J, Lozano F
Eur J Immunol. 2001
PubMed ID: 11298344
A unique role for Fyn in CNS myelination.
Sperber BR, Boyle-Walsh EA, Engleka MJ, Gadue P, Peterson AC, Stein PL, Scherer SS, McMorris FA
J Neurosci. 2001
PubMed ID: 11245687
TGF-beta abrogates TCR-mediated signaling by upregulating tyrosine phosphatases in T cells.
Choudhry MA, Sir O, Sayeed MM
Shock. 2001
PubMed ID: 11236902
A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens.
Thut CJ, Rountree RB, Hwa M, Kingsley DM
Dev Biol. 2001
PubMed ID: 11180952
Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway.
Linseman DA, Heidenreich KA, Fisher SK
J Biol Chem. 2001
PubMed ID: 11087735
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.
Nakamura T, Yamashita H, Takahashi T, Nakamura S
Biochem Biophys Res Commun. 2001
PubMed ID: 11162638
RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.
Thien CB, Walker F, Langdon WY
Mol Cell. 2001
PubMed ID: 11239464
Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke.
Paul R, Zhang ZG, Eliceiri BP, Jiang Q, Boccia AD, Zhang RL, Chopp M, Cheresh DA
Nat Med. 2001
PubMed ID: 11175854
p59fyn (Fyn) promotes the survival of anergic CD4-CD8- alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation.
Utting O, Priatel JJ, Teh SJ, Teh HS
J Immunol. 2001
PubMed ID: 11160194
SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF.
Wang B, Lemay S, Tsai S, Veillette A
Mol Cell Biol. 2001
PubMed ID: 11158295
Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn.
Yu CC, Yen TS, Lowell CA, DeFranco AL
Curr Biol. 2001
PubMed ID: 11166177
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor.
Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T
J Biol Chem. 2001
PubMed ID: 11024032
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.
Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL
BMC Immunol. 2001
PubMed ID: 11353545
Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway.
Quek LS, Pasquet JM, Hers I, Cornall R, Knight G, Barnes M, Hibbs ML, Dunn AR, Lowell CA, Watson SP
Blood. 2000
PubMed ID: 11110698
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling.
Miki H, Yamaguchi H, Suetsugu S, Takenawa T
Nature. 2000
PubMed ID: 11130076
Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia.
Ishiguro H, Saito T, Shibuya H, Toru M, Arinami T
Am J Med Genet. 2000
PubMed ID: 11121167
A critical role for p59(fyn) in CD2-based signal transduction.
Fukai I, Hussey RE, Sunder-Plassmann R, Reinherz EL
Eur J Immunol. 2000
PubMed ID: 11093170
The protein tyrosine kinase family of the human genome.
Robinson DR, Wu YM, Lin SF
Oncogene. 2000
PubMed ID: 11114734
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.
Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB
J Biol Chem. 2000
PubMed ID: 10945997
A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation.
Cabodi S, Calautti E, Talora C, Kuroki T, Stein PL, Dotto GP
Mol Cell. 2000
PubMed ID: 11106751
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor.
Imokawa G, Kobayasi T, Miyagishi M
J Biol Chem. 2000
PubMed ID: 10921922
Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase.
Del Giudice E, Gaetaniello L, Matrecano E, Cosentini E, Ursini MV, Racioppi L, Arrigo G, Pignata C
Neuropediatrics. 2000
PubMed ID: 11204284
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo.
Assarsson E, Kambayashi T, Sandberg JK, Hong S, Taniguchi M, Van Kaer L, Ljunggren HG, Chambers BJ
J Immunol. 2000
PubMed ID: 11034371
Severe hypomyelination of the murine CNS in the absence of myelin-associated glycoprotein and fyn tyrosine kinase.
Biffiger K, Bartsch S, Montag D, Aguzzi A, Schachner M, Bartsch U
J Neurosci. 2000
PubMed ID: 11007902
T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.
Huang J, Tilly D, Altman A, Sugie K, Grey HM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11005864
Decreased locomotor activity in mice carrying transgenic Fyn tyrosine kinase.
Ishibashi H, Kojima N, Obata K
Biochem Biophys Res Commun. 2000
PubMed ID: 11027535
Collagen, convulxin, and thrombin stimulate aggregation-independent tyrosine phosphorylation of CD31 in platelets. Evidence for the involvement of Src family kinases.
Cicmil M, Thomas JM, Sage T, Barry FA, Leduc M, Bon C, Gibbins JM
J Biol Chem. 2000
PubMed ID: 10858437
The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.
Sasaoka T, Kobayashi M
Endocr J. 2000
PubMed ID: 11075717
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.
Schaak S, Cussac D, Cayla C, Devedjian JC, Guyot R, Paris H, Denis C
Gut. 2000
PubMed ID: 10896916
Changes in circadian period and morphology of the hypothalamic suprachiasmatic nucleus in fyn kinase-deficient mice.
Shima T, Yagi T, Isojima Y, Okumura N, Okada M, Nagai K
Brain Res. 2000
PubMed ID: 10869499
Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells.
Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K
J Biol Chem. 2000
PubMed ID: 10764799
Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402.
Katagiri T, Takahashi T, Sasaki T, Nakamura S, Hattori S
J Biol Chem. 2000
PubMed ID: 10867021
Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family.
Langlais P, Dong LQ, Hu D, Liu F
Oncogene. 2000
PubMed ID: 10871840
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.
Satterthwaite AB, Willis F, Kanchanastit P, Fruman D, Cantley LC, Helgason CD, Humphries RK, Lowell CA, Simon M, Leitges M, Tarakhovsky A, Tedder TF, Lesche R, Wu H, Witte ON
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10829070
The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase.
Slack BE
Biochem J. 2000
PubMed ID: 10816433
Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.
Iseki M, Takaki S, Takatsu K
Biochem Biophys Res Commun. 2000
PubMed ID: 10872802
Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.
Chen LM, Bailey D, Fernandez-Valle C
J Neurosci. 2000
PubMed ID: 10804218
Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
Scholz G, Cartledge K, Dunn AR
J Biol Chem. 2000
PubMed ID: 10799548
Classical oncogenes and tumor suppressor genes: a comparative genomics perspective.
Pickeral OK, Li JZ, Barrow I, Boguski MS, Makałowski W, Zhang J
Neoplasia. 2000
PubMed ID: 10935514
Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system.
Seiwa C, Sugiyama I, Yagi T, Iguchi T, Asou H
Neurosci Res. 2000
PubMed ID: 10802341
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B
J Exp Med. 2000
PubMed ID: 10790433
Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells.
Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK
Exp Cell Res. 2000
PubMed ID: 10739664
A novel pro-Arg motif recognized by WW domains.
Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB
J Biol Chem. 2000
PubMed ID: 10744724
Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.
Lemay S, Davidson D, Latour S, Veillette A
Mol Cell Biol. 2000
PubMed ID: 10733577
HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells.
Ingley E, Sarna MK, Beaumont JG, Tilbrook PA, Tsai S, Takemoto Y, Williams JH, Klinken SP
J Biol Chem. 2000
PubMed ID: 10713104
Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain.
Chow A, Davis AJ, Gawler DJ
FEBS Lett. 2000
PubMed ID: 10708762
Dynamic characteristics and adaptability of reflex eye movements of Fyn-kinase-deficient mice.
Kitazawa H, Katoh A, Yagi T, Nagao S
Neurosci Lett. 2000
PubMed ID: 10675790
Lck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitions.
Lin K, Longo NS, Wang X, Hewitt JA, Abraham KM
J Exp Med. 2000
PubMed ID: 10684862
Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.
Briggs SD, Lerner EC, Smithgall TE
Biochemistry. 2000
PubMed ID: 10642173
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.
Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ
J Biol Chem. 2000
PubMed ID: 10636929
Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes.
Perez-Villar JJ, Kanner SB
J Immunol. 1999
PubMed ID: 10586033
Proteins of the CNR family are multiple receptors for Reelin.
Senzaki K, Ogawa M, Yagi T
Cell. 1999
PubMed ID: 10612399
Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.
Eliceiri BP, Paul R, Schwartzberg PL, Hood JD, Leng J, Cheresh DA
Mol Cell. 1999
PubMed ID: 10635317
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.
Geng L, Raab M, Rudd CE
J Immunol. 1999
PubMed ID: 10570256
A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn.
Sayeski PP, Ali MS, Safavi A, Lyles M, Kim SO, Frank SJ, Bernstein KE
J Biol Chem. 1999
PubMed ID: 10551884
The conserved core of human immunodeficiency virus type 1 Nef is essential for association with Lck and for enhanced viral replication in T-lymphocytes.
Cheng H, Hoxie JP, Parks WP
Virology. 1999
PubMed ID: 10544125
Physical and functional association of LFA-1 with DNAM-1 adhesion molecule.
Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A
Immunity. 1999
PubMed ID: 10591186
The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).
Hartmann AM, Nayler O, Schwaiger FW, Obermeier A, Stamm S
Mol Biol Cell. 1999
PubMed ID: 10564280
The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.
Beard MB, O'Connell JC, Bolger GB, Houslay MD
FEBS Lett. 1999
PubMed ID: 10571082
Molecular cloning and characterization of a novel cbl-family gene, cbl-c.
Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T
Gene. 1999
PubMed ID: 10571044
The Src family tyrosine kinase Fyn regulates natural killer T cell development.
Gadue P, Morton N, Stein PL
J Exp Med. 1999
PubMed ID: 10523617
Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice.
Eberl G, Lowin-Kropf B, MacDonald HR
J Immunol. 1999
PubMed ID: 10510341
Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.
Choi S, Park S
Oncogene. 1999
PubMed ID: 10498895
SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor.
Marchetto S, Fournier E, Beslu N, Aurran-Schleinitz T, Dubreuil P, Borg JP, Birnbaum D, Rosnet O
Leukemia. 1999
PubMed ID: 10482988
Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling.
Horikawa K, Nishizumi H, Umemori H, Aizawa S, Takatsu K, Yamamoto T
Int Immunol. 1999
PubMed ID: 10464165
Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression.
Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A
J Immunol. 1999
PubMed ID: 10453000
Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase.
Banin S, Gout I, Brickell P
Mol Biol Rep. 1999
PubMed ID: 10532312
The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains.
Takagi N, Cheung HH, Bissoon N, Teves L, Wallace MC, Gurd JW
J Cereb Blood Flow Metab. 1999
PubMed ID: 10458595
Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes.
Ricci JE, Maulon L, Luciano F, Guerin S, Livolsi A, Mari B, Breittmayer JP, Peyron JF, Auberger P
Oncogene. 1999
PubMed ID: 10435619
Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn.
Ron D, Napolitano EW, Voronova A, Vasquez NJ, Roberts DN, Calio BL, Caothien RH, Pettiford SM, Wellik S, Mandac JB, Kauvar LM
J Biol Chem. 1999
PubMed ID: 10383400
Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase.
Osterhout DJ, Wolven A, Wolf RM, Resh MD, Chao MV
J Cell Biol. 1999
PubMed ID: 10366594
CMS: an adapter molecule involved in cytoskeletal rearrangements.
Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10339567
Src family kinases are required for integrin but not PDGFR signal transduction.
Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P
EMBO J. 1999
PubMed ID: 10228160
Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in T-cell receptor-mediated signalling.
Kanda H, Mimura T, Hamasaki K, Yamamoto K, Yazaki Y, Hirai H, Nojima Y
Immunology. 1999
PubMed ID: 10447714
Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.
Weil R, Levraud JP, Dodon MD, Bessia C, Hazan U, Kourilsky P, Israël A
J Virol. 1999
PubMed ID: 10196263
Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells.
Tang H, Zhao ZJ, Huang XY, Landon EJ, Inagami T
J Biol Chem. 1999
PubMed ID: 10212213
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B
J Exp Med. 1999
PubMed ID: 10209036
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
Howlett CJ, Bisson SA, Resek ME, Tigley AW, Robbins SM
Biochem Biophys Res Commun. 1999
PubMed ID: 10092522
Embryonic stem cells can be used to construct hybrid cell lines containing a single, selectable murine chromosome.
Jakobs PM, Smith L, Thayer M, Grompe M
Mamm Genome. 1999
PubMed ID: 10087297
Wiskott-Aldrich syndrome protein, WASP.
O'Sullivan E, Kinnon C, Brickell P
Int J Biochem Cell Biol. 1999
PubMed ID: 10224664
Genetic localization and transmission of the mouse osteopetrotic grey-lethal mutation.
Vacher J, Bernard H
Mamm Genome. 1999
PubMed ID: 10051318
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R
EMBO J. 1999
PubMed ID: 10022833
Timing and casting for actors of thymic negative selection.
Dautigny N, Le Campion A, Lucas B
J Immunol. 1999
PubMed ID: 9973382
Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB
J Immunol. 1999
PubMed ID: 9973379
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Hunter S, Burton EA, Wu SC, Anderson SM
J Biol Chem. 1999
PubMed ID: 9890970
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.
Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9892651
Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice.
Lu YF, Kojima N, Tomizawa K, Moriwaki A, Matsushita M, Obata K, Matsui H
Eur J Neurosci. 1999
PubMed ID: 9987012
Transcriptional map of chromosome region 6q16-->q21.
Karayianni E, Magnanini C, Orphanos V, Negrini M, Maniatis GM, Spathas DH, Barbanti-Brodano G, Morelli C
Cytogenet Cell Genet. 1999
PubMed ID: 10575223
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes.
Helland R, Berglund GI, Otlewski J, Apostoluk W, Andersen OA, Willassen NP, Smalås AO
Acta Crystallogr D Biol Crystallogr. 1999
PubMed ID: 10089404
Two species of mRNAs for the fyn proto-oncogene are produced by an alternative polyadenylation.
Lee C, Kim MG, Jeon SH, Park DE, Park SD, Seong RH
Mol Cells. 1998
PubMed ID: 9895129
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
Zhu T, Goh EL, LeRoith D, Lobie PE
J Biol Chem. 1998
PubMed ID: 9837978
ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.
Brown MT, Andrade J, Radhakrishna H, Donaldson JG, Cooper JA, Randazzo PA
Mol Cell Biol. 1998
PubMed ID: 9819391
RA70 is a src kinase-associated protein expressed ubiquitously.
Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T
Biochem Biophys Res Commun. 1998
PubMed ID: 9837776
Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.
Michel F, Grimaud L, Tuosto L, Acuto O
J Biol Chem. 1998
PubMed ID: 9822663
Angiotensin II-induced tyrosine phosphorylation of signal transducers and activators of transcription 1 is regulated by Janus-activated kinase 2 and Fyn kinases and mitogen-activated protein kinase phosphatase 1.
Venema RC, Venema VJ, Eaton DC, Marrero MB
J Biol Chem. 1998
PubMed ID: 9804857
Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation.
Timokhina I, Kissel H, Stella G, Besmer P
EMBO J. 1998
PubMed ID: 9799234
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.
Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A
Immunity. 1998
PubMed ID: 9846481
Tau interacts with src-family non-receptor tyrosine kinases.
Lee G, Newman ST, Gard DL, Band H, Panchamoorthy G
J Cell Sci. 1998
PubMed ID: 9763511
Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice.
Kojima N, Ishibashi H, Obata K, Kandel ER
Learn Mem. 1998
PubMed ID: 10489260
Son of sevenless binds to the SH3 domain of src-type tyrosine kinase.
Park C, Choi Y, Yun Y
Mol Cells. 1998
PubMed ID: 9856337
RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.
Arold S, O'Brien R, Franken P, Strub MP, Hoh F, Dumas C, Ladbury JE
Biochemistry. 1998
PubMed ID: 9778343
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.
Sieg DJ, Ilić D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD
EMBO J. 1998
PubMed ID: 9774338
Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK).
Anfosso F, Bardin N, Francès V, Vivier E, Camoin-Jau L, Sampol J, Dignat-George F
J Biol Chem. 1998
PubMed ID: 9756930
Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.
Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA
J Biol Chem. 1998
PubMed ID: 9748251
Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.
Ohba T, Ishino M, Aoto H, Sasaki T
Anal Biochem. 1998
PubMed ID: 9750131
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.
Wary KK, Mariotti A, Zurzolo C, Giancotti FG
Cell. 1998
PubMed ID: 9741627
Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).
Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T
Biochem Biophys Res Commun. 1998
PubMed ID: 9712716
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.
Bruyns E, Marie-Cardine A, Kirchgessner H, Sagolla K, Shevchenko A, Mann M, Autschbach F, Bensussan A, Meuer S, Schraven B
J Exp Med. 1998
PubMed ID: 9687533
Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc.
Walk SF, March ME, Ravichandran KS
Eur J Immunol. 1998
PubMed ID: 9710204
Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.
Lin H, Hutchcroft JE, Andoniou CE, Kamoun M, Band H, Bierer BE
J Biol Chem. 1998
PubMed ID: 9677430
Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions.
Hock B, Böhme B, Karn T, Feller S, Rübsamen-Waigmann H, Strebhardt K
Oncogene. 1998
PubMed ID: 9674711
The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
Chan VW, Mecklenbräuker I, Su I, Texido G, Leitges M, Carsetti R, Lowell CA, Rajewsky K, Miyake K, Tarakhovsky A
J Exp Med. 1998
PubMed ID: 9653087
p59fyn and pp60c-src modulate axonal guidance in the developing mouse olfactory pathway.
Morse WR, Whitesides JG, LaMantia AS, Maness PF
J Neurobiol. 1998
PubMed ID: 9658338
Association of the Src family tyrosine kinase Fyn with TrkB.
Iwasaki Y, Gay B, Wada K, Koizumi S
J Neurochem. 1998
PubMed ID: 9648856
T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation.
Pedraza-Alva G, Mérida LB, Burakoff SJ, Rosenstein Y
J Biol Chem. 1998
PubMed ID: 9603925
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.
Kohmura N, Senzaki K, Hamada S, Kai N, Yasuda R, Watanabe M, Ishii H, Yasuda M, Mishina M, Yagi T
Neuron. 1998
PubMed ID: 9655502
T cells expressing receptors of different affinity for antigen ligands reveal a unique role for p59fyn in T cell development and optimal stimulation of T cells by antigen.
Utting O, Teh SJ, Teh HS
J Immunol. 1998
PubMed ID: 9605142
CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes.
Ilangumaran S, Briol A, Hoessli DC
Blood. 1998
PubMed ID: 9573028
Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets.
Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9576921
Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region.
Zisch AH, Kalo MS, Chong LD, Pasquale EB
Oncogene. 1998
PubMed ID: 9632142
Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth.
Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng HB, Rauvala H
J Biol Chem. 1998
PubMed ID: 9553134
Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.
Deckert M, Elly C, Altman A, Liu YC
J Biol Chem. 1998
PubMed ID: 9535867
Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn.
Bhandari V, Lim KL, Pallen CJ
J Biol Chem. 1998
PubMed ID: 9535845
Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction.
Pao LI, Famiglietti SJ, Cambier JC
J Immunol. 1998
PubMed ID: 9531288
Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.
Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D
J Biol Chem. 1998
PubMed ID: 9507006
Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C.
Soltoff SP, Avraham H, Avraham S, Cantley LC
J Biol Chem. 1998
PubMed ID: 9446569
Prostaglandin E2 modulation of p59fyn tyrosine kinase in T lymphocytes during sepsis.
Choudhry MA, Uddin S, Sayeed MM
J Immunol. 1998
PubMed ID: 9551931
The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells.
Dumler I, Weis A, Mayboroda OA, Maasch C, Jerke U, Haller H, Gulba DC
J Biol Chem. 1998
PubMed ID: 9417082
Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice.
Kitazawa H, Yagi T, Miyakawa T, Niki H, Kawai N
J Neurophysiol. 1998
PubMed ID: 9425184
PDGF-induced phosphorylation of Tyr28 in the N-terminus of Fyn affects Fyn activation.
Hansen K, Alonso G, Courtneidge SA, Rönnstrand L, Heldin CH
Biochem Biophys Res Commun. 1997
PubMed ID: 9425276
Itk and Fyn make independent contributions to T cell activation.
Liao XC, Littman DR, Weiss A
J Exp Med. 1997
PubMed ID: 9396778
Prolactin induced tyrosine phosphorylation of p59fyn may mediate phosphatidylinositol 3-kinase activation in Nb2 cells.
al-Sakkaf KA, Dobson PR, Brown BL
J Mol Endocrinol. 1997
PubMed ID: 9460655
Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1.
Hunter AJ, Shimizu Y
J Immunol. 1997
PubMed ID: 9366405
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates.
Tachibana K, Urano T, Fujita H, Ohashi Y, Kamiguchi K, Iwata S, Hirai H, Morimoto C
J Biol Chem. 1997
PubMed ID: 9360983
Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.
Tamma SM, Chirmule N, McCloskey TW, Oyaizu N, Kalyanaraman VS, Pahwa S
Clin Immunol Immunopathol. 1997
PubMed ID: 9344703
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function.
Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, Niki H
Science. 1997
PubMed ID: 9381182
A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.
Matuoka K, Miki H, Takahashi K, Takenawa T
Biochem Biophys Res Commun. 1997
PubMed ID: 9344857
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Arold S, Franken P, Strub MP, Hoh F, Benichou S, Benarous R, Dumas C
Structure. 1997
PubMed ID: 9351809
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity.
Mulhern TD, Shaw GL, Morton CJ, Day AJ, Campbell ID
Structure. 1997
PubMed ID: 9351806
Co-localization of Fyn with CD3 complex, CD45 or CD28 depends on different mechanisms.
zur Hausen JD, Burn P, Amrein KE
Eur J Immunol. 1997
PubMed ID: 9368621
Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling.
Bourette RP, Myles GM, Choi JL, Rohrschneider LR
EMBO J. 1997
PubMed ID: 9312046
A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets.
Tsuji M, Ezumi Y, Arai M, Takayama H
J Biol Chem. 1997
PubMed ID: 9295288
A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5.
Yasue T, Nishizumi H, Aizawa S, Yamamoto T, Miyake K, Mizoguchi C, Uehara S, Kikuchi Y, Takatsu K
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9294206
Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase.
Oda T, Kujovich J, Reis M, Newman B, Druker BJ
Oncogene. 1997
PubMed ID: 9315092
Suppression of autoimmune disease and of massive lymphadenopathy in MRL/Mp-lpr/lpr mice lacking tyrosine kinase Fyn (p59fyn).
Takahashi T, Yagi T, Kakinuma S, Kurokawa A, Okada T, Takatsu K, Aizawa S, Katagiri T
J Immunol. 1997
PubMed ID: 9278347
CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.
Tamma SM, Chirmule N, Yagura H, Oyaizu N, Kalyanaraman V, Pahwa S
Blood. 1997
PubMed ID: 9269777
Skin abnormality in aged fyn-/- fak+/- mice.
Ilić D, Kanazawa S, Nishizumi H, Aizawa S, Kuroki T, Mori S, Yamamoto T
Carcinogenesis. 1997
PubMed ID: 9276618
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.
da Silva AJ, Li Z, de Vera C, Canto E, Findell P, Rudd CE
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207119
Binding of src-like kinases to the beta-subunit of the interleukin-3 receptor.
Burton EA, Hunter S, Wu SC, Anderson SM
J Biol Chem. 1997
PubMed ID: 9195918
Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes.
Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B
J Biol Chem. 1997
PubMed ID: 9195899
Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2.
Manié SN, Astier A, Haghayeghi N, Canty T, Druker BJ, Hirai H, Freedman AS
J Biol Chem. 1997
PubMed ID: 9188452
Interaction of p59fyn with interferon-activated Jak kinases.
Uddin S, Sher DA, Alsayed Y, Pons S, Colamonici OR, Fish EN, White MF, Platanias LC
Biochem Biophys Res Commun. 1997
PubMed ID: 9196040
Identification of novel human WW domain-containing proteins by cloning of ligand targets.
Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM
J Biol Chem. 1997
PubMed ID: 9169421
Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association.
Wolven A, Okamura H, Rosenblatt Y, Resh MD
Mol Biol Cell. 1997
PubMed ID: 9201723
Molecular cloning of Fyn-associated molecules in the mouse central nervous system.
Kai N, Mishina M, Yagi T
J Neurosci Res. 1997
PubMed ID: 9185665
Mouse CD24 as a signaling molecule for integrin-mediated cell binding: functional and physical association with src-kinases.
Sammar M, Gulbins E, Hilbert K, Lang F, Altevogt P
Biochem Biophys Res Commun. 1997
PubMed ID: 9177270
The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.
Miner JH, Patton BL, Lentz SI, Gilbert DJ, Snider WD, Jenkins NA, Copeland NG, Sanes JR
J Cell Biol. 1997
PubMed ID: 9151674
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene.
Kojima N, Wang J, Mansuy IM, Grant SG, Mayford M, Kandel ER
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9114065
Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling.
Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A
J Exp Med. 1997
PubMed ID: 9104812
Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation.
Gotoh N, Toyoda M, Shibuya M
Mol Cell Biol. 1997
PubMed ID: 9121430
NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn).
Beggs HE, Baragona SC, Hemperly JJ, Maness PF
J Biol Chem. 1997
PubMed ID: 9079653
RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes.
Ganju RK, Hatch WC, Avraham H, Ona MA, Druker B, Avraham S, Groopman JE
J Exp Med. 1997
PubMed ID: 9091579
Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirement for NH2-terminal myristoylation and palmitoylation at cysteine-3.
van't Hof W, Resh MD
J Cell Biol. 1997
PubMed ID: 9060467
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J
J Biol Chem. 1997
PubMed ID: 9045636
Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.
Peles E, Nativ M, Lustig M, Grumet M, Schilling J, Martinez R, Plowman GD, Schlessinger J
EMBO J. 1997
PubMed ID: 9118959
The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ
J Clin Invest. 1997
PubMed ID: 9062339
Lck regulates Vav activation of members of the Rho family of GTPases.
Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D
Mol Cell Biol. 1997
PubMed ID: 9032261
Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.
Price DJ, Rivnay B, Fu Y, Jiang S, Avraham S, Avraham H
J Biol Chem. 1997
PubMed ID: 9038210
Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.
Tailor P, Gilman J, Williams S, Couture C, Mustelin T
J Biol Chem. 1997
PubMed ID: 9038134
A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase C gamma2 in platelets independent of the integrin alpha2beta1.
Asselin J, Gibbins JM, Achison M, Lee YH, Morton LF, Farndale RW, Barnes MJ, Watson SP
Blood. 1997
PubMed ID: 9028946
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
Raab M, da Silva AJ, Findell PR, Rudd CE
Immunity. 1997
PubMed ID: 9047237
Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development.
Page ST, van Oers NS, Perlmutter RM, Weiss A, Pullen AM
Eur J Immunol. 1997
PubMed ID: 9045930
The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling.
Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE
J Biol Chem. 1997
PubMed ID: 8995379
HIV glycoprotein gp120 inhibits TCR-CD3-mediated activation of fyn and lck.
Morio T, Chatila T, Geha RS
Int Immunol. 1997
PubMed ID: 9043947
Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells.
Shimizu Y, Sugiyama H, Fujii Y, Sasaki K, Inoue K, Ogawa H, Tamaki H, Miyake S, Oji Y, Soma T, Yamagami T, Hirata M, Ikeda K, Monden T, Kishimoto T
Am J Hematol. 1997
PubMed ID: 8980254
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Renzoni DA, Pugh DJ, Siligardi G, Das P, Morton CJ, Rossi C, Waterfield MD, Campbell ID, Ladbury JE
Biochemistry. 1996
PubMed ID: 8961927
Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice.
Miyakawa T, Yagi T, Tateishi K, Niki H
Neuroreport. 1996
PubMed ID: 8981455
Expression of tyrosine kinase gene in mouse thymic stromal cells.
Rinke de Wit TF, Izon DJ, Revilla C, Oosterwegel M, Bakker AQ, van Ewijk W, Kruisbeek AM
Int Immunol. 1996
PubMed ID: 8943574
alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.
van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A
Immunity. 1996
PubMed ID: 8934570
Fyn can partially substitute for Lck in T lymphocyte development.
Groves T, Smiley P, Cooke MP, Forbush K, Perlmutter RM, Guidos CJ
Immunity. 1996
PubMed ID: 8934569
The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2.
Pathan NI, Geahlen RL, Harrison ML
J Biol Chem. 1996
PubMed ID: 8910336
Identification of Itk/Tsk Src homology 3 domain ligands.
Bunnell SC, Henry PA, Kolluri R, Kirchhausen T, Rickles RJ, Berg LJ
J Biol Chem. 1996
PubMed ID: 8810341
The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP.
Davis AJ, Butt JT, Walker JH, Moss SE, Gawler DJ
J Biol Chem. 1996
PubMed ID: 8798684
Thy-1 molecule associates with protein tyrosine kinase(s) in rat mesangial cells.
Narisawa-Saito M, Yamanashi Y, Morioka T, Oite T, Shimizu F
Clin Exp Immunol. 1996
PubMed ID: 8870703
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
HIV infection in vitro enhances the activity of src-family protein tyrosine kinases.
Phipps DJ, Read SE, Piovesan JP, Mills GB, Branch DR
AIDS. 1996
PubMed ID: 8883579
In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation.
Bewarder N, Weinrich V, Budde P, Hartmann D, Flaswinkel H, Reth M, Frey J
Mol Cell Biol. 1996
PubMed ID: 8756631
The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).
O'Connell JC, McCallum JF, McPhee I, Wakefield J, Houslay ES, Wishart W, Bolger G, Frame M, Houslay MD
Biochem J. 1996
PubMed ID: 8761480
Taste aversion learning in fyn mutant mice.
Schafe GE, Stein PL, Park CR, Bernstein IL
Behav Neurosci. 1996
PubMed ID: 8864276
Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases.
Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I
Curr Biol. 1996
PubMed ID: 8805332
Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM
J Exp Med. 1996
PubMed ID: 8760790
Preservation of spatial learning in fyn tyrosine kinase knockout mice.
Huerta PT, Scearce KA, Farris SM, Empson RM, Prusky GT
Neuroreport. 1996
PubMed ID: 8904782
Impaired development of CD4+ CD8+ thymoyctes by csk-'knock-in' into fyn locus.
Kanazawa S, Ilic D, Hashiyama M, Okada M, Noumura T, Aizawa S, Suda T
Oncogene. 1996
PubMed ID: 8700547
Solution structure and peptide binding of the SH3 domain from human Fyn.
Morton CJ, Pugh DJ, Brown EL, Kahmann JD, Renzoni DA, Campbell ID
Structure. 1996
PubMed ID: 8805554
Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain.
Lee CH, Saksela K, Mirza UA, Chait BT, Kuriyan J
Cell. 1996
PubMed ID: 8681387
Multiple features of the p59fyn src homology 4 domain define a motif for immune-receptor tyrosine-based activation motif (ITAM) binding and for plasma membrane localization.
Timson Gauen LK, Linder ME, Shaw AS
J Cell Biol. 1996
PubMed ID: 8655574
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
Sun XJ, Pons S, Asano T, Myers MG, Glasheen E, White MF
J Biol Chem. 1996
PubMed ID: 8631859
Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness.
Miyakawa T, Yagi T, Kagiyama A, Niki H
Brain Res Mol Brain Res. 1996
PubMed ID: 8738145
A physical interaction between the cell death protein Fas and the tyrosine kinase p59fynT.
Atkinson EA, Ostergaard H, Kane K, Pinkoski MJ, Caputo A, Olszowy MW, Bleackley RC
J Biol Chem. 1996
PubMed ID: 8626376
Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta.
Denning MF, Dlugosz AA, Threadgill DW, Magnuson T, Yuspa SH
J Biol Chem. 1996
PubMed ID: 8621384
An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro.
Forrester LM, Nagy A, Sam M, Watt A, Stevenson L, Bernstein A, Joyner AL, Wurst W
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643689
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H
J Biol Chem. 1996
PubMed ID: 8621719
Altered brain fyn kinase in a murine acquired immunodeficiency syndrome.
Sei Y, Whitesell L, Kustova Y, Paul IA, Morse HC, Skolnick P, Basile AS
FASEB J. 1996
PubMed ID: 8641568
p59fyn-p125FAK cooperation in development of CD4+CD8+ thymocytes.
Kanazawa S, Ilić D, Hashiyama M, Noumura T, Yamamoto T, Suda T, Aizawa S
Blood. 1996
PubMed ID: 8562954
Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein JL, Tessier-Lavigne M
Mol Cell Neurosci. 1996
PubMed ID: 8812055
HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation.
Tian H, Lempicki R, King L, Donoghue E, Samelson LE, Cohen DI
Int Immunol. 1996
PubMed ID: 8671590
Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn.
Ishino M, Ohba T, Sasaki H, Sasaki T
Oncogene. 1995
PubMed ID: 8570184
Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase.
Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B
Eur J Immunol. 1995
PubMed ID: 8566014
Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.
Wang XY, Fuhrer DK, Marshall MS, Yang YC
J Biol Chem. 1995
PubMed ID: 7499280
The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum.
Olive S, Dubois C, Schachner M, Rougon G
J Neurochem. 1995
PubMed ID: 7595520
Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain.
Hane M, Lowin B, Peitsch M, Becker K, Tschopp J
FEBS Lett. 1995
PubMed ID: 7589480
A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.
Lee CH, Leung B, Lemmon MA, Zheng J, Cowburn D, Kuriyan J, Saksela K
EMBO J. 1995
PubMed ID: 7588629
Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains.
Chalupny NJ, Aruffo A, Esselstyn JM, Chan PY, Bajorath J, Blake J, Gilliland LK, Ledbetter JA, Tepper MA
Eur J Immunol. 1995
PubMed ID: 7589101
The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor zeta chain tyrosine-based activation motif.
Osman N, Lucas S, Cantrell D
Eur J Immunol. 1995
PubMed ID: 7589084
Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains.
Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC
Mol Cell Biol. 1995
PubMed ID: 7565724
Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.
Deans JP, Kalt L, Ledbetter JA, Schieven GL, Bolen JB, Johnson P
J Biol Chem. 1995
PubMed ID: 7545683
fyn tyrosine kinase is involved in keratinocyte differentiation control.
Calautti E, Missero C, Stein PL, Ezzell RM, Dotto GP
Genes Dev. 1995
PubMed ID: 7557381
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
Raab M, Cai YC, Bunnell SC, Heyeck SD, Berg LJ, Rudd CE
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7568038
Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase.
Reith AD
Mamm Genome. 1995
PubMed ID: 8535092
Involvement of p59fynT in interleukin-5 receptor signaling.
Appleby MW, Kerner JD, Chien S, Maliszewski CR, Bondada S, Perlmutter RM, Bondadaa S [corrected to Bondada S
J Exp Med. 1995
PubMed ID: 7650487
The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase.
Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H
J Biol Chem. 1995
PubMed ID: 7642581
Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.
Grant SG, Karl KA, Kiebler MA, Kandel ER
Genes Dev. 1995
PubMed ID: 7544314
Induction of lytic pathways in T cell clones derived from wild-type or protein tyrosine kinase Fyn mutant mice.
Lancki DW, Fields P, Qian D, Fitch FW
Immunol Rev. 1995
PubMed ID: 7493751
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.
Thomas SM, Soriano P, Imamoto A
Nature. 1995
PubMed ID: 7617039
Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins.
Neumeister EN, Zhu Y, Richard S, Terhorst C, Chan AC, Shaw AS
Mol Cell Biol. 1995
PubMed ID: 7760813
Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
Lancki DW, Qian D, Fields P, Gajewski T, Fitch FW
J Immunol. 1995
PubMed ID: 7722293
Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.
Toshima J, Ohashi K, Iwashita S, Mizuno K
Biochem Biophys Res Commun. 1995
PubMed ID: 7537495
Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
Alexandropoulos K, Cheng G, Baltimore D
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7536925
Differential regulation of fyn-associated protein tyrosine kinase activity by macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF).
Li Y, Chen B
J Leukoc Biol. 1995
PubMed ID: 7884321
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.
Saksela K, Cheng G, Baltimore D
EMBO J. 1995
PubMed ID: 7859737
Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.
Rigley K, Slocombe P, Proudfoot K, Wahid S, Mandair K, Bebbington C
J Immunol. 1995
PubMed ID: 7822789
Enhanced susceptibility of audiogenic seizures in Fyn-kinase deficient mice.
Miyakawa T, Yagi T, Taniguchi M, Matsuura H, Tateishi K, Niki H
Brain Res Mol Brain Res. 1995
PubMed ID: 7723633
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.
Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, Shaw AS
Mol Cell Biol. 1995
PubMed ID: 7799925
Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Lee GH, Bennett LM, Carabeo RA, Drinkwater NR
Genetics. 1995
PubMed ID: 7705639
Identification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules.
Jaramillo ML, Afar DE, Almazan G, Bell JC
J Biol Chem. 1994
PubMed ID: 7525550
Palmitoylation of multiple Src-family kinases at a homologous N-terminal motif.
Koegl M, Zlatkine P, Ley SC, Courtneidge SA, Magee AI
Biochem J. 1994
PubMed ID: 7980442
NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice.
Beggs HE, Soriano P, Maness PF
J Cell Biol. 1994
PubMed ID: 7962063
Increased fearfulness of Fyn tyrosine kinase deficient mice.
Miyakawa T, Yagi T, Watanabe S, Niki H
Brain Res Mol Brain Res. 1994
PubMed ID: 7877449
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH
J Biol Chem. 1994
PubMed ID: 7929439
Fyn expression during early neurogenesis in mouse embryos.
Yagi T, Shigetani Y, Furuta Y, Nada S, Okado N, Ikawa Y, Aizawa S
Oncogene. 1994
PubMed ID: 8058305
Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.
Stein PL, Vogel H, Soriano P
Genes Dev. 1994
PubMed ID: 7958873
Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells.
Bull HA, Brickell PM, Dowd PM
FEBS Lett. 1994
PubMed ID: 7521304
Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.
Cheng G, Ye ZS, Baltimore D
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8058772
High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Musacchio A, Saraste M, Wilmanns M
Nat Struct Biol. 1994
PubMed ID: 7664083
Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.
Larsson-Blomberg L, Dzierzak E
FEBS Lett. 1994
PubMed ID: 8034026
Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells.
Davidson D, Viallet J, Veillette A
Mol Cell Biol. 1994
PubMed ID: 8007959
Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner.
Cleghon V, Morrison DK
J Biol Chem. 1994
PubMed ID: 7517401
Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains.
Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, Michael WM, Dreyfuss G, Brugge JS
Mol Cell Biol. 1994
PubMed ID: 7516469
Activation of src family kinases in human pre-B cells by IL-7.
Seckinger P, Fougereau M
J Immunol. 1994
PubMed ID: 7515933
Dual myristylation and palmitylation of Src family member p59fyn affects subcellular localization.
Alland L, Peseckis SM, Atherton RE, Berthiaume L, Resh MD
J Biol Chem. 1994
PubMed ID: 8206991
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif.
Gauen LK, Zhu Y, Letourneur F, Hu Q, Bolen JB, Matis LA, Klausner RD, Shaw AS
Mol Cell Biol. 1994
PubMed ID: 8196616
The protein tyrosine kinase P59fyn is associated with prolactin (PRL) receptor and is activated by PRL stimulation of T-lymphocytes.
Clevenger CV, Medaglia MV
Mol Endocrinol. 1994
PubMed ID: 7935483
CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.
Burns CM, Sakaguchi K, Appella E, Ashwell JD
J Biol Chem. 1994
PubMed ID: 8175795
Gene order is conserved within the human chromosome 21 linkage group on mouse chromosome 10.
Irving NG, Cabin DE, Swanson DA, Reeves RH
Genomics. 1994
PubMed ID: 7916323
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.
Clark MR, Johnson SA, Cambier JC
EMBO J. 1994
PubMed ID: 8168489
Initial events of myelination involve Fyn tyrosine kinase signalling.
Umemori H, Sato S, Yagi T, Aizawa S, Yamamoto T
Nature. 1994
PubMed ID: 7509042
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
Kapeller R, Prasad KV, Janssen O, Hou W, Schaffhausen BS, Rudd CE, Cantley LC
J Biol Chem. 1994
PubMed ID: 8294442
Non-receptor tyrosine kinases in mammalian neurogenesis.
Aizawa S, Yagi T, Furuta Y, Ikawa Y, Nada S, Nakagawa H, Okada M
Princess Takamatsu Symp. 1994
PubMed ID: 8983085
Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system.
Takeuchi M, Kuramochi S, Fusaki N, Nada S, Kawamura-Tsuzuku J, Matsuda S, Semba K, Toyoshima K, Okada M, Yamamoto T
J Biol Chem. 1993
PubMed ID: 8262983
A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice.
Yagi T, Aizawa S, Tokunaga T, Shigetani Y, Takeda N, Ikawa Y
Nature. 1993
PubMed ID: 8264796
Regional localization of Fyn in adult brain; studies with mice in which fyn gene was replaced by lacZ.
Yagi T, Shigetani Y, Okado N, Tokunaga T, Ikawa Y, Aizawa S
Oncogene. 1993
PubMed ID: 8247536
T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T).
da Silva AJ, Janssen O, Rudd CE
J Exp Med. 1993
PubMed ID: 7504057
The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter.
Wenger RH, Rochelle JM, Seldin MF, Köhler G, Nielsen PJ
J Biol Chem. 1993
PubMed ID: 8226859
Spatial learning in mutant mice.
Deutsch JA
Science. 1993
PubMed ID: 8235598
The GTPase dynamin binds to and is activated by a subset of SH3 domains.
Gout I, Dhand R, Hiles ID, Fry MJ, Panayotou G, Das P, Truong O, Totty NF, Hsuan J, Booker GW
Cell. 1993
PubMed ID: 8402898
Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.
Shenoy-Scaria AM, Gauen LK, Kwong J, Shaw AS, Lublin DM
Mol Cell Biol. 1993
PubMed ID: 8413237
The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation.
Garnett D, Barclay AN, Carmo AM, Beyers AD
Eur J Immunol. 1993
PubMed ID: 8104794
Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.
Pleiman CM, Clark MR, Gauen LK, Winitz S, Coggeshall KM, Johnson GL, Shaw AS, Cambier JC
Mol Cell Biol. 1993
PubMed ID: 8395016
Physical association of the cytoplasmic domain of CD2 with the tyrosine kinases p56lck and p59fyn.
Carmo AM, Mason DW, Beyers AD
Eur J Immunol. 1993
PubMed ID: 8103744
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
Prasad KV, Janssen O, Kapeller R, Raab M, Cantley LC, Rudd CE
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8394019
Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.
Noble ME, Musacchio A, Saraste M, Courtneidge SA, Wierenga RK
EMBO J. 1993
PubMed ID: 7687536
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
Science. 1993
PubMed ID: 8493579
Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.
Kobayashi N, Kono T, Hatakeyama M, Minami Y, Miyazaki T, Perlmutter RM, Taniguchi T
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8483935
In vitro tyrosine phosphorylation of PLC-gamma 1 and PLC-gamma 2 by src-family protein tyrosine kinases.
Liao F, Shin HS, Rhee SG
Biochem Biophys Res Commun. 1993
PubMed ID: 7682059
Differential effects of expression of the CD45 tyrosine protein phosphatase on the tyrosine phosphorylation of the lck, fyn, and c-src tyrosine protein kinases.
Hurley TR, Hyman R, Sefton BM
Mol Cell Biol. 1993
PubMed ID: 8441403
Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.
Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF
EMBO J. 1993
PubMed ID: 7681396
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.
Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER
Science. 1992
PubMed ID: 1361685
Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD.
da Silva AJ, Yamamoto M, Zalvan CH, Rudd CE
Mol Immunol. 1992
PubMed ID: 1454062
Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1.
Shenoy-Scaria AM, Kwong J, Fujita T, Olszowy MW, Shaw AS, Lublin DM
J Immunol. 1992
PubMed ID: 1385527
Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system.
Umemori H, Wanaka A, Kato H, Takeuchi M, Tohyama M, Yamamoto T
Brain Res Mol Brain Res. 1992
PubMed ID: 1337939
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system.
Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, Waterfield MD
Biochem J. 1992
PubMed ID: 1334406
Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells.
Bell GM, Bolen JB, Imboden JB
Mol Cell Biol. 1992
PubMed ID: 1280324
High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.
Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, Schlessinger J
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1409582
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn.
Appleby MW, Gross JA, Cooke MP, Levin SD, Qian X, Perlmutter RM
Cell. 1992
PubMed ID: 1516132
pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells.
Stein PL, Lee HM, Rich S, Soriano P
Cell. 1992
PubMed ID: 1387588
Chromosomal mapping of the human (MACS) and mouse (Macs) genes encoding the MARCKS protein.
Blackshear PJ, Tuttle JS, Oakey RJ, Seldin MF, Chery M, Philippe C, Stumpo DJ
Genomics. 1992
PubMed ID: 1427822
The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells.
Thomas PM, Samelson LE
J Biol Chem. 1992
PubMed ID: 1351058
Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase.
Mustelin T, Pessa-Morikawa T, Autero M, Gassmann M, Andersson LC, Gahmberg CG, Burn P
Eur J Immunol. 1992
PubMed ID: 1533589
Induction of Fc epsilon RII/CD23 on PHA-activated human peripheral blood T lymphocytes and the association of Fyn tyrosine kinase with Fc epsilon RII/CD23.
Maekawa N, Kawabe T, Sugie K, Kawakami T, Iwata S, Uchida A, Yodoi J
Res Immunol. 1992
PubMed ID: 1387715
Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.
Beyers AD, Spruyt LL, Williams AF
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1372996
p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets.
Cichowski K, McCormick F, Brugge JS
J Biol Chem. 1992
PubMed ID: 1544885
Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping.
Haefliger JA, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG, Paul DL
J Biol Chem. 1992
PubMed ID: 1370487
Protein tyrosine kinase p59fyn is associated with the T cell receptor-CD3 complex in functional human lymphocytes.
Gassmann M, Guttinger M, Amrein KE, Burn P
Eur J Immunol. 1992
PubMed ID: 1530920
Induction of Fc epsilon RII/CD23 on PHA-activated human peripheral blood T lymphocytes and association of fyn tyrosine kinase with Fc epsilon RII/CD23.
Maekawa N, Kawabe T, Sugie K, Kawakami T, Maeda Y, Uchida A, Yodoi J
Int J Tissue React. 1992
PubMed ID: 1446976
The p60c-src family of protein-tyrosine kinases: structure, regulation, and function.
Brickell PM
Crit Rev Oncog. 1992
PubMed ID: 1384720
CSK: a protein-tyrosine kinase involved in regulation of src family kinases.
Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H
J Biol Chem. 1991
PubMed ID: 1722201
Fyn tyrosine kinase associated with Fc epsilon RII/CD23: possible multiple roles in lymphocyte activation.
Sugie K, Kawakami T, Maeda Y, Kawabe T, Uchida A, Yodoi J
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1717997
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.
Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1715582
Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).
Cooke MP, Abraham KM, Forbush KA, Perlmutter RM
Cell. 1991
PubMed ID: 2015626
Novel putative protein kinase clones from a rat large granular lymphocyte tumor cell line.
Yue CC
Mol Immunol. 1991
PubMed ID: 2062320
Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen.
Cheng SH, Espino PC, Marshall J, Harvey R, Merrill J, Smith AE
J Virol. 1991
PubMed ID: 1985196
In vivo phosphorylation and membrane association of the fyn proto-oncogene product in IM-9 human lymphoblasts.
Peters DJ, McGrew BR, Perron DC, Liptak LM, Laudano AP
Oncogene. 1990
PubMed ID: 1699196
Association between the PDGF receptor and members of the src family of tyrosine kinases.
Kypta RM, Goldberg Y, Ulug ET, Courtneidge SA
Cell. 1990
PubMed ID: 1696179
A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross.
Justice MJ, Siracusa LD, Gilbert DJ, Heisterkamp N, Groffen J, Chada K, Silan CM, Copeland NG, Jenkins NA
Genetics. 1990
PubMed ID: 1975791
Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.
Dymecki SM, Niederhuber JE, Desiderio SV
Science. 1990
PubMed ID: 2404338
Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.
Cooke MP, Perlmutter RM
New Biol. 1989
PubMed ID: 2488273
Chromosomal localization of the human fyn gene.
Popescu NC, Kawakami T, Matsui T, Robbins KC
Oncogene. 1987
PubMed ID: 3330788
Isolation and oncogenic potential of a novel human src-like gene.
Kawakami T, Pennington CY, Robbins KC
Mol Cell Biol. 1986
PubMed ID: 3099169
yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.
Semba K, Nishizawa M, Miyajima N, Yoshida MC, Sukegawa J, Yamanashi Y, Sasaki M, Yamamoto T, Toyoshima K
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3526330
Classical conditioning of blood pressure in Macaca mulatta with cardiac rate controlled.
Turkkan JS, Schoenfeld WN
Pavlov J Biol Sci. 1979
PubMed ID: 119942
The behavior of holo- and apo-forms of bovine superoxide dismutase at low pH.
Fee JA, Phillips WD
Biochim Biophys Acta. 1975
PubMed ID: 82

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2534	14360	25150
EnsEMBL Gene(s)	ENSG00000010810	ENSMUSG00000019843	ENSRNOG00000000596
Unigene	Hs.390567	Mm.4848	Rn.19361
Homologene	FYN	Fyn	Fyn
OMIM	137025	N/A	N/A
GeneCards	FYN	N/A	N/A
Beta Cell Genomics	DT.121320911 DT.86843886 DT.92435837 DT.95132434 DT.95289422	DT.101277672 DT.101725436 DT.534255 DT.94309707 DT.99840621	N/A
Reactome	P06241	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	2534	14360	25150

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
FYN	HDAC6	IntAct	empirical	17474147
FYN	HCN4	IntAct	empirical	17474147
FYN	CHAF1A	IntAct	empirical	17474147
FYN	TOM1L1	HPRD	empirical	11711534
FYN	G3BP1	MINT	empirical	15743820
FYN	WASF2	HPRD	empirical	10532312
FYN	TNK2	HPRD	empirical	14506255 11087735
FYN	CDK5	HPRD	empirical	12372285
FYN	FLOT1	HPRD	empirical	11598189
FYN	HNRNPR	IntAct	empirical	17474147
FYN	SF3B4	IntAct	empirical	17474147
FYN	TRAIP	IntAct	empirical	17474147
FYN	TUBA1B	HPRD	empirical	11826099
FYN	GNB2L1	HPRD	empirical	11943848 12524444
FYN	RPP38	IntAct	empirical	17474147
FYN	CENPA	IntAct	empirical	17474147
FYN	SH2B2	HPRD	empirical	10872802
FYN	TGOLN2	IntAct	empirical	17474147
FYN	KHDRBS1	HPRD, MINT, IntAct	empirical	9045636 7516469 15102471
FYN	CD226	HPRD	empirical	10591186
FYN	GRAP	HPRD	empirical	8995379
FYN	BAZ2A	IntAct	empirical	17474147
FYN	MAP4K5	IntAct	empirical	17474147
FYN	MAP4K1	IntAct	empirical	17474147
FYN	GPR45	IntAct	empirical	17474147
FYN	CSMD2	IntAct	empirical	17474147
FYN	ARHGAP33	HPRD, IntAct	empirical	16777849
FYN	CLNK	MINT	empirical	12681493
FYN	ADD2	HPRD	empirical	11526103
FYN	RAVER1	MINT, IntAct	empirical	15102471
FYN	CNN1	HPRD	empirical	15206927
FYN	CNN3	HPRD	empirical	15206927
FYN	CNTFR	IntAct	empirical	17474147
FYN	CNTN1	HPRD	empirical	7595520
FYN	DUSP15	IntAct	empirical	17474147
FYN	GAB3	HPRD	empirical	11739737
FYN	CRK	HPRD	empirical	9837978
FYN	TRIM69	IntAct	empirical	20360068
FYN	CSF1R	HPRD	empirical	7681396
FYN	CSF2RB	HPRD	empirical	9195918
FYN	CSK	HPRD	empirical	8262983 1985196
FYN	CTLA4	HPRD	empirical	9712716 9973379
FYN	CTNNB1	HPRD, MINT	empirical	12640114
FYN	CTNND2	HPRD	empirical	12835311
FYN	DAB2	IntAct	empirical	17474147
FYN	CD55	HPRD	empirical	1385527
FYN	DAG1	IntAct	empirical	17474147
FYN	DLG4	HPRD	empirical	12419528
FYN	DLX4	IntAct	empirical	17474147
FYN	DNASE1L2	IntAct	empirical	17474147
FYN	DOCK1	IntAct	empirical	17474147
FYN	DOCK3	IntAct	empirical	17474147
FYN	DOK1	HPRD	empirical	15345598
FYN	CELSR3	IntAct	empirical	17474147
FYN	EPHA4	HPRD	empirical	12084815
FYN	EPHA8	HPRD	empirical	10498895
FYN	EPHB3	HPRD	empirical	9674711
FYN	EPS15	IntAct	empirical	17474147
FYN	EXTL3	IntAct	empirical	17474147
FYN	F2RL2	IntAct	empirical	17474147
FYN	FANCA	IntAct	empirical	17474147
FYN	PTK2B	HPRD, MINT, IntAct	empirical	9091579 10867021 9104812 15102471
FYN	FCER2	HPRD	empirical	1387715 1446976 1717997
FYN	FCGR2A	HPRD	empirical	8756631
FYN	FCGR2B	IntAct	empirical	17474147
FYN	DLGAP4	IntAct	empirical	17474147
FYN	FOXF2	IntAct	empirical	17474147
FYN	RIMS1	IntAct	empirical	17474147
FYN	NFASC	IntAct	empirical	17474147
FYN	EPB41L3	IntAct	empirical	17474147
FYN	FLNA	IntAct	empirical	17474147
FYN	FLNC	IntAct	empirical	17474147
FYN	FLOT2	HPRD	empirical	11598189
FYN	FLT1	HPRD	empirical	12509223
FYN	VPS13A	IntAct	empirical	17474147
FYN	FN1	MINT	empirical	17130124
FYN	FNBP4	HPRD	empirical	10744724
FYN	CD2AP	HPRD, IntAct	empirical	10339567 17474147
FYN	ABL1	IntAct	empirical	17474147
FYN	NR5A1	IntAct	empirical	17474147
FYN	FYB	HPRD, MINT, IntAct	empirical	7504057 9207119 10570256 12681493 17474147
FYN	FYN	IntAct	empirical	14993658
FYN	GABBR1	IntAct	empirical	17474147
FYN	GAD1	IntAct	empirical	17474147
FYN	COBRA1	IntAct	empirical	17474147
FYN	DNM3	IntAct	empirical	17474147
FYN	NBEA	IntAct	empirical	17474147
FYN	ABL2	IntAct	empirical	17474147
FYN	LAT	IntAct	empirical	16938345
FYN	DKKL1	IntAct	empirical	17474147
FYN	BRPF3	IntAct	empirical	17474147
FYN	SIT1	HPRD	empirical	10209036
FYN	GNS	IntAct	empirical	17474147
FYN	CCR10	IntAct	empirical	17474147
FYN	NEK8	IntAct	empirical	17474147
FYN	GRB2	HPRD, Reactome	empirical	9344857 7537740 9525940 18374639 8995358 9259313 9590251
FYN	GRB10	HPRD	empirical	10871840
FYN	RAPGEF1	IntAct	empirical	17474147
FYN	GRIN2A	HPRD	empirical	12932824 10458595
FYN	GRIN2B	HPRD	empirical	10458595 11024032 11483655
FYN	NR3C1	HPRD	empirical	16888650
FYN	GSTZ1	IntAct	empirical	17474147
FYN	GTF3A	IntAct	empirical	17474147
FYN	SNX8	IntAct	empirical	17474147
FYN	SNX12	IntAct	empirical	17474147
FYN	GUCY2D	IntAct	empirical	17474147
FYN	HCLS1	IntAct	empirical	10713104
FYN	HEXA	IntAct	empirical	17474147
FYN	HNRNPK	HPRD, MINT	empirical	7516469 9185665
FYN	HOXC8	IntAct	empirical	17474147
FYN	AIRE	IntAct	empirical	17474147
FYN	HRAS	HPRD, MINT	empirical	12695509
FYN	HSP90AA1	HPRD	empirical	16888650
FYN	HTR6	HPRD, MINT, IntAct	empirical	17189269
FYN	NCKAP5	IntAct	empirical	17474147
FYN	FAS	HPRD, MINT	empirical	8626376 17159908
FYN	FASLG	HPRD, IntAct	empirical	7589480 19807924
FYN	IL2RB	HPRD	empirical	8483935
FYN	IL3RA	IntAct	empirical	17474147
FYN	SHROOM2	IntAct	empirical	17474147
FYN	IL7R	HPRD	empirical	7515933
FYN	IRS1	HPRD	empirical	8631859
FYN	ITGB4	HPRD	empirical	11684709
FYN	ITK	HPRD	empirical	8810341
FYN	ITPR1	HPRD	empirical	14761954
FYN	JAK2	HPRD	empirical	10551884
FYN	JUP	HPRD	empirical	14517306
FYN	KDR	HPRD, MINT	empirical	7929439 16966330
FYN	KIT	HPRD	empirical	12374739 9799234
FYN	LCP2	HPRD	empirical	9047237
FYN	PRICKLE3	IntAct	empirical	17474147
FYN	LTBP2	IntAct	empirical	17474147
FYN	LYN	Reactome	predicted	11943772
FYN	SH2D1A	HPRD, MINT	empirical	12545174 10089404 16983070 12545173
FYN	MAG	HPRD	empirical	7525550
FYN	MAP2	MINT	empirical	15536091
FYN	MAPT	HPRD, MINT	empirical	11826099 16014719 16115884
FYN	MBP	MINT	empirical	18067320
FYN	MCAM	HPRD	empirical	9756930
FYN	MKI67	IntAct	empirical	17474147
FYN	MOS	IntAct	empirical	17474147
FYN	PPP1R12A	IntAct	empirical	17474147
FYN	NCAM1	HPRD	empirical	11839780 9079653
FYN	NCK1	MINT	empirical	16966330
FYN	NEDD9	HPRD	empirical	9360983
FYN	NMT1	HPRD	empirical	11423543 11594778
FYN	NPHS1	HPRD	empirical	12846735 12668668
FYN	NTRK2	HPRD	empirical	9648856
FYN	ORC1	IntAct	empirical	17474147
FYN	PAK2	HPRD, MINT	empirical	16374509
FYN	PAX3	IntAct	empirical	17474147
FYN	ASAP1	MINT, IntAct	empirical	16636290 17474147 9819391
FYN	PAX7	IntAct	empirical	17474147
FYN	TRAT1	HPRD	empirical	9687533
FYN	GP6	HPRD, IntAct	empirical	11943772 1715582
FYN	DDX41	IntAct	empirical	17474147
FYN	EVL	HPRD	empirical	10945997
FYN	NCKIPSD	IntAct	empirical	17474147
FYN	PDGFRB	HPRD	empirical	1696179 9425276
FYN	PECAM1	HPRD	empirical	10858437
FYN	ACP1	HPRD	empirical	9038134
FYN	PIK3R1	HPRD, MINT	empirical	8394019 8294442 8395016
FYN	PIK3R2	HPRD	empirical	1334406
FYN	PKD1	IntAct	empirical	17474147
FYN	PLAUR	HPRD	empirical	9417082
FYN	PLCG1	HPRD	empirical	10586033
FYN	PLCG2	HPRD, MINT	empirical	8395016 12181444 7682059 15144186
FYN	PLD2	HPRD	empirical	12697812
FYN	PLXNA1	Reactome	predicted
FYN	PLXNA2	Reactome	predicted
FYN	POLD1	IntAct	empirical	17474147
FYN	PPP1R3D	IntAct	empirical	17474147
FYN	PLXNA3	Reactome	predicted
FYN	DOK4	HPRD	empirical	12730241
FYN	PRKCD	HPRD, IntAct	empirical	8621384 10383400 12721299
FYN	PRKCE	HPRD	empirical	8621384
FYN	PAG1	HPRD	empirical	10790433
FYN	PRKCH	HPRD	empirical	8621384
FYN	PRKCQ	HPRD, IntAct	empirical	10383400
FYN	PRKCZ	HPRD	empirical	8621384
FYN	TDRD1	IntAct	empirical	17474147
FYN	TRIM39	IntAct	empirical	17474147
FYN	SPHK2	HPRD, IntAct	empirical	16316995
FYN	MEPE	IntAct	empirical	17474147
FYN	TULP4	IntAct	empirical	17474147
FYN	RTN4	IntAct	empirical	17474147
FYN	SEPN1	IntAct	empirical	17474147
FYN	PTK2	HPRD, MINT, IntAct	empirical	11278857 15102471
FYN	PRX	IntAct	empirical	17474147
FYN	PTPN4	IntAct	empirical	17474147
FYN	PTPN11	HPRD	empirical	10212213
FYN	PTPRA	HPRD	empirical	9535845 8980254
FYN	PTPRC	HPRD	empirical	9368621 12589038 9535845 8980254
FYN	PTPRE	HPRD	empirical	14980517 15588985
FYN	PTPRF	HPRD	empirical	12496362
FYN	PTPRZ1	HPRD	empirical	15925565
FYN	PXN	HPRD	empirical	10804218
FYN	DLGAP3	IntAct	empirical	17474147
FYN	RAF1	HPRD	empirical	7517401
FYN	RASA1	MINT	empirical	8395016
FYN	TRPV4	HPRD	empirical	12538589
FYN	BCL3	HPRD, MINT	empirical	9576921 16099425
FYN	TSKS	IntAct	empirical	17474147
FYN	HCN2	IntAct	empirical	17474147
FYN	RRAS	IntAct	empirical	17474147
FYN	ATXN1	HPRD, MINT, IntAct	empirical	16713569
FYN	NPVF	IntAct	empirical	17474147
FYN	SH3BP2	HPRD	empirical	15345594
FYN	SHC1	HPRD, MINT	empirical	7516469 12237775 11075717 10764799 9121430 9446569 10816433 10896916 10921922 9741627 9710204 10482988
FYN	PDIA2	IntAct	empirical	17474147
FYN	SLAMF1	HPRD, MINT	empirical	12458214 11806999 12545173 16847311 11477403
FYN	WNK2	IntAct	empirical	17474147
FYN	BMP8B	IntAct	empirical	17474147
FYN	SNCA	HPRD	empirical	11162638 12096713 11744621
FYN	SOS1	HPRD, IntAct	empirical	9856337 17474147
FYN	SOS2	IntAct	empirical	17474147
FYN	SP1	IntAct	empirical	17474147
FYN	SPN	HPRD	empirical	9603925
FYN	SRC	MINT	empirical	16966330
FYN	BRCA2	IntAct	empirical	17474147
FYN	STAT1	HPRD	empirical	9804857
FYN	CDKL5	IntAct	empirical	17474147
FYN	SYK	HPRD	empirical	9535867
FYN	GCFC2	IntAct	empirical	17474147
FYN	DYNLT1	MINT, IntAct	empirical	15102471
FYN	THY1	HPRD	empirical	1351058
FYN	NKX2-1	IntAct	empirical	17474147
FYN	TMPO	IntAct	empirical	17474147
FYN	TRPC6	HPRD	empirical	14761972
FYN	TUBA4A	HPRD	empirical	8566014
FYN	TUBA3C	HPRD	empirical	11826099 8566014
FYN	TULP1	IntAct	empirical	17474147
FYN	C6	IntAct	empirical	17474147
FYN	TXK	HPRD	empirical	11353545
FYN	TYK2	HPRD	empirical	9196040
FYN	TYRO3	HPRD	empirical	7537495
FYN	UCK2	MINT, IntAct	empirical	15102471
FYN	VAV1	HPRD	empirical	9822663
FYN	WAS	HPRD, MINT	empirical	10224664 8805332 10532312 7565724 14707117
FYN	WIPF1	IntAct	empirical	17474147
FYN	XRCC1	IntAct	empirical	17474147
FYN	YWHAB	IntAct	empirical	16635246
FYN	ZAP70	HPRD	empirical	7760813
FYN	CACNA1F	IntAct	empirical	17474147
FYN	SUV39H2	IntAct	empirical	17474147
FYN	RIN3	IntAct	empirical	17474147
FYN	DOK3	HPRD	empirical	10733577
FYN	MED28	HPRD, MINT, IntAct	empirical	16899217 16964398
FYN	APOL5	IntAct	empirical	17474147
FYN	GPR63	IntAct	empirical	17474147
FYN	ISG20L2	IntAct	empirical	17474147
FYN	CAST	IntAct	empirical	17474147
FYN	FAM110A	IntAct	empirical	17474147
FYN	CASP3	HPRD	empirical	10435619
FYN	CASP8	HPRD	empirical	10435619
FYN	SEMA7A	IntAct	empirical	17474147
FYN	PTPN5	HPRD	empirical	11983687
FYN	CNTNAP1	HPRD, IntAct	empirical	9118959 17474147
FYN	CYP4F2	IntAct	empirical	17474147
FYN	SHANK3	IntAct	empirical	17474147
FYN	TCAP	IntAct	empirical	21988832
FYN	CAV1	HPRD	empirical	12529448
FYN	SKAP1	HPRD	empirical	9195899
FYN	SOCS1	HPRD	empirical	10022833
FYN	CBL	HPRD, MINT, BioGRID, Reactome	empirical	9535867 8621719 119942 82 11239464 9890970 10092522 10799548 7642581 15556646 17094785 19734451 7537740 9525940 18374639 8995358 9259313 9590251
FYN	CBLB	HPRD, MINT	empirical	16503409 9890970
FYN	SNX3	IntAct	empirical	17474147
FYN	ADAM15	HPRD, MINT	empirical	11741929 16374509
FYN	NRP1	Reactome	predicted
FYN	ASAP2	IntAct	empirical	17474147
FYN	CCKBR	IntAct	empirical	17474147
FYN	SYNJ2	IntAct	empirical	17474147
FYN	SPHK1	HPRD, IntAct	empirical	16316995
FYN	SKAP2	HPRD, MINT	empirical	9837776 12681493
FYN	WASF1	HPRD	empirical	10532312
FYN	NFS1	IntAct	empirical	17474147
FYN	UNC119	HPRD	empirical	14757743
FYN	FCGR2C	IntAct	empirical	17474147
FYN	SCARF2	IntAct	empirical	17474147
FYN	CD2	HPRD, MINT	empirical	9677430
FYN	PLXNA4	Reactome	predicted
FYN	YTHDC1	HPRD	empirical	15175272
FYN	SLC24A1	IntAct	empirical	17474147
FYN	CD247	HPRD	empirical	1454062 1530920 7589084 8760790 9368621
FYN	CD5	HPRD	empirical	11298344 15144186
FYN	DLGAP2	IntAct	empirical	17474147
FYN	DLGAP1	IntAct	empirical	17474147
FYN	ASB16	IntAct	empirical	17474147
FYN	MED14	IntAct	empirical	17474147
FYN	CD19	HPRD	empirical	7589101
FYN	MS4A1	HPRD	empirical	7545683
FYN	RP1L1	IntAct	empirical	17474147
FYN	CD86	Reactome	predicted	9973466 8946678
FYN	AKAP6	IntAct	empirical	17474147
FYN	CD36	HPRD	empirical	7521304
FYN	BCAR1	HPRD, MINT, IntAct	empirical	9188452 17129785 17474147 15102471
FYN	CD44	HPRD	empirical	9573028
FYN	CD48	HPRD	empirical	8104794
FYN	SDC3	HPRD	empirical	9553134
FYN	RIMS2	IntAct	empirical	17474147
FYN	CD79A	HPRD	empirical	9531288
FYN	CD79B	HPRD	empirical	9531288
FYN	ARHGAP32	HPRD, IntAct	empirical	12788081 12857875
FYN	MLL4	IntAct	empirical	17474147
FYN	SNX17	IntAct	empirical	17474147
FYN	CKAP5	IntAct	empirical	17474147
FYN	ARHGEF11	IntAct	empirical	17474147
FYN	CDK1	HPRD	empirical	8910336
FYN	LRBA	IntAct	empirical	17474147
FYN	CDC27	IntAct	empirical	17474147