FUS

Summary Top Help

Gene Description:

fusion, derived from t(12;16) malignant liposarcoma (human); fused in sarcoma

Synonyms:

Tls, FUS, TLS, D430004D17Rik, POMP75, Fus1, FUS1, ALS6, Fus, HNRNPP2, D930039C12Rik

Orthologs:

Human FUS (protein-coding), Mouse Fus (protein-coding), Rat Fus (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	508

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm10	Rat	chr1:178054386..201472944	23.42	321

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr16:31191431..31206192 (14.76 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:135110971..135125882 (14.91 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:187250871..187264742 (13.87 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for FUS:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for FUS:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 7

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 15

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 182

FUS mutations in sporadic amyotrophic lateral sclerosis: Clinical and genetic analysis.
Sproviero W, La Bella V, Mazzei R, Valentino P, Rodolico C, Simone IL, Logroscino G, Ungaro C, Magariello A, Patitucci A, Tedeschi G, Spataro R, Condino F, Bono F, Citrigno L, Monsurrò MR, Muglia M, Gambardella A, Quattrone A, Conforti FL
Neurobiol Aging. 2012
PubMed ID: 22055719
Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS
J Proteomics. 2011
PubMed ID: 22178446
Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.
Akimov V, Rigbolt KT, Nielsen MM, Blagoev B
Mol Biosyst. 2011
PubMed ID: 21956701
Transportin1: a marker of FTLD-FUS.
Brelstaff J, Lashley T, Holton JL, Lees AJ, Rossor MN, Bandopadhyay R, Revesz T
Acta Neuropathol. 2011
PubMed ID: 21847626
Low-grade fibromyxoid sarcoma of the perineum with heterotopic ossification: case report and review of the literature.
Lee AF, Yip S, Smith AC, Hayes MM, Nielsen TO, O'Connell JX
Hum Pathol. 2011
PubMed ID: 21658743
Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS.
Ito D, Suzuki N
Neurology. 2011
PubMed ID: 21956718
The ALS-associated proteins FUS and TDP-43 function together to affect Drosophila locomotion and life span.
Wang JW, Brent JR, Tomlinson A, Shneider NA, McCabe BD
J Clin Invest. 2011
PubMed ID: 21881207
Clinical and neuroanatomical signatures of tissue pathology in frontotemporal lobar degeneration.
Rohrer JD, Lashley T, Schott JM, Warren JE, Mead S, Isaacs AM, Beck J, Hardy J, de Silva R, Warrington E, Troakes C, Al-Sarraj S, King A, Borroni B, Clarkson MJ, Ourselin S, Holton JL, Fox NC, Revesz T, Rossor MN, Warren JD
Brain. 2011
PubMed ID: 21908872
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, Mackenzie IR
Brain. 2011
PubMed ID: 21856723
A comparative clinical, pathological, biochemical and genetic study of fused in sarcoma proteinopathies.
Lashley T, Rohrer JD, Bandopadhyay R, Fry C, Ahmed Z, Isaacs AM, Brelstaff JH, Borroni B, Warren JD, Troakes C, King A, Al-Saraj S, Newcombe J, Quinn N, Ostergaard K, Schrøder HD, Bojsen-Møller M, Braendgaard H, Fox NC, Rossor MN, Lees AJ, Holton JL, Revesz T
Brain. 2011
PubMed ID: 21752791
PGC-1α regulates translocated in liposarcoma activity: role in oxidative stress gene expression.
Sánchez-Ramos C, Tierrez A, Fabregat-Andrés O, Wild B, Sánchez-Cabo F, Arduini A, Dopazo A, Monsalve M
Antioxid Redox Signal. 2011
PubMed ID: 21338289
Low-grade fibromyxoid sarcoma of the small intestine: report of 4 cases with molecular cytogenetic confirmation.
Laurini JA, Zhang L, Goldblum JR, Montgomery E, Folpe AL
Am J Surg Pathol. 2011
PubMed ID: 21677541
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation.
Mackenzie IR, Ansorge O, Strong M, Bilbao J, Zinman L, Ang LC, Baker M, Stewart H, Eisen A, Rademakers R, Neumann M
Acta Neuropathol. 2011
PubMed ID: 21604077
A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.
Lanson NA, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE, Pandey UB
Hum Mol Genet. 2011
PubMed ID: 21487023
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
FUS gene mutations associated with familiar forms of amyotrophic lateral sclerosis affect cellular localization and aggregation properties of the encoded protein.
Shelkovnikova TA, Ustyugov AA, Smirnov AP, Skvortsova VI, Buchman VL, Bachurin SO, Ninkina NN
Dokl Biochem Biophys. 2011
PubMed ID: 21725888
FUS-CREB3L2/L1-positive sarcomas show a specific gene expression profile with upregulation of CD24 and FOXL1.
Möller E, Hornick JL, Magnusson L, Veerla S, Domanski HA, Mertens F
Clin Cancer Res. 2011
PubMed ID: 21536545
mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.
Spitzer JI, Ugras S, Runge S, Decarolis P, Antonescu C, Tuschl T, Singer S
Genes Chromosomes Cancer. 2011
PubMed ID: 21344536
A yeast model of FUS/TLS-dependent cytotoxicity.
Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH, Lindquist S, Ringe D, Petsko GA
PLoS Biol. 2011
PubMed ID: 21541368
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.
Sun Z, Diaz Z, Fang X, Hart MP, Chesi A, Shorter J, Gitler AD
PLoS Biol. 2011
PubMed ID: 21541367
FUS (16p11) gene rearrangement as detected by fluorescence in-situ hybridization in cutaneous low-grade fibromyxoid sarcoma: a potential diagnostic tool.
Patel RM, Downs-Kelly E, Dandekar MN, Fanburg-Smith JC, Billings SD, Tubbs RR, Goldblum JR
Am J Dermatopathol. 2011
PubMed ID: 21399449
Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations.
Kino Y, Washizu C, Aquilanti E, Okuno M, Kurosawa M, Yamada M, Doi H, Nukina N
Nucleic Acids Res. 2011
PubMed ID: 21109527
FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis.
Kryndushkin D, Wickner RB, Shewmaker F
Protein Cell. 2011
PubMed ID: 21452073
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Huang C, Zhou H, Tong J, Chen H, Liu YJ, Wang D, Wei X, Xia XG
PLoS Genet. 2011
PubMed ID: 21408206
No effect on SOD1 splicing by TARDP or FUS mutations.
Belzil VV, Daoud H, Dion PA, Rouleau GA
Arch Neurol. 2011
PubMed ID: 21403029
Extraskeletal Ewing's sarcoma in a 67-year-old man.
Hanaoka N, Goto T, Kasai T, Matsuura T, Nishisho T, Enishi T, Yasui N
J Orthop Sci. 2011
PubMed ID: 21327980
Identification of novel FUS mutations in sporadic cases of amyotrophic lateral sclerosis.
Belzil VV, Daoud H, St-Onge J, Desjarlais A, Bouchard JP, Dupre N, Lacomblez L, Salachas F, Pradat PF, Meininger V, Camu W, Dion PA, Rouleau GA
Amyotroph Lateral Scler. 2011
PubMed ID: 21261515
Identification of a FUS splicing mutation in a large family with amyotrophic lateral sclerosis.
Belzil VV, St-Onge J, Daoud H, Desjarlais A, Bouchard JP, Dupré N, Camu W, Dion PA, Rouleau GA
J Hum Genet. 2011
PubMed ID: 21160488
FUS/TLS gene mutations are the second most frequent cause of familial ALS in the Spanish population.
Syriani E, Morales M, Gamez J
Amyotroph Lateral Scler. 2011
PubMed ID: 21128870
Sclerosing epithelioid fibrosarcoma - a report of two cases with cytogenetic analysis of FUS gene rearrangement by FISH technique.
Rekhi B, Folpe AL, Deshmukh M, Jambhekar NA
Pathol Oncol Res. 2011
PubMed ID: 20499220
FUS mutations in sporadic amyotrophic lateral sclerosis.
Lai SL, Abramzon Y, Schymick JC, Stephan DA, Dunckley T, Dillman A, Cookson M, Calvo A, Battistini S, Giannini F, Caponnetto C, Mancardi GL, Spataro R, Monsurro MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Lombardo F, ITALSGEN Consortium, Mora G, Restagno G, Chiò A, Traynor BJ
Neurobiol Aging. 2011
PubMed ID: 20138404
FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.
Rodriguez R, Rubio R, Gutierrez-Aranda I, Melen GJ, Elosua C, García-Castro J, Menendez P
Stem Cells. 2011
PubMed ID: 21732477
FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth.
Brooke GN, Culley RL, Dart DA, Mann DJ, Gaughan L, McCracken SR, Robson CN, Spencer-Dene B, Gamble SC, Powell SM, Wait R, Waxman J, Walker MM, Bevan CL
Cancer Res. 2011
PubMed ID: 21169411
The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease.
Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IR, Perry RH, Skullerud K, Yokoo H, Cairns NJ
Acta Neuropathol. 2011
PubMed ID: 20886222
TLS and PRMT1 synergistically coactivate transcription at the survivin promoter through TLS arginine methylation.
Du K, Arai S, Kawamura T, Matsushita A, Kurokawa R
Biochem Biophys Res Commun. 2011
PubMed ID: 21187067
Promoter-associated long noncoding RNAs repress transcription through a RNA binding protein TLS.
Kurokawa R
Adv Exp Med Biol. 2011
PubMed ID: 21915790
FUS/TLS is a co-activator of androgen receptor in prostate cancer cells.
Haile S, Lal A, Myung JK, Sadar MD
PLoS One. 2011
PubMed ID: 21909421
Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS.
Ito D, Seki M, Tsunoda Y, Uchiyama H, Suzuki N
Ann Neurol. 2011
PubMed ID: 21280085
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ, Sapp P, McKenna-Yasek D, Brown RH, Hayward LJ
Hum Mol Genet. 2010
PubMed ID: 20699327
Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
Kim SH, Shanware NP, Bowler MJ, Tibbetts RS
J Biol Chem. 2010
PubMed ID: 20720006
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia.
Mackenzie IR, Rademakers R, Neumann M
Lancet Neurol. 2010
PubMed ID: 20864052
A Japanese ALS6 family with mutation R521C in the FUS/TLS gene: a clinical, pathological and genetic report.
Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M
J Neurol Sci. 2010
PubMed ID: 20621307
Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia.
Yan J, Deng HX, Siddique N, Fecto F, Chen W, Yang Y, Liu E, Donkervoort S, Zheng JG, Shi Y, Ahmeti KB, Brooks B, Engel WK, Siddique T
Neurology. 2010
PubMed ID: 20668259
Novel missense and truncating mutations in FUS/TLS in familial ALS.
Waibel S, Neumann M, Rabe M, Meyer T, Ludolph AC
Neurology. 2010
PubMed ID: 20660363
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C
EMBO J. 2010
PubMed ID: 20606625
Juvenile ALS with basophilic inclusions is a FUS proteinopathy with FUS mutations.
Bäumer D, Hilton D, Paine SM, Turner MR, Lowe J, Talbot K, Ansorge O
Neurology. 2010
PubMed ID: 20668261
SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V
J Med Genet. 2010
PubMed ID: 20577002
Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis.
Rademakers R, Stewart H, Dejesus-Hernandez M, Krieger C, Graff-Radford N, Fabros M, Briemberg H, Cashman N, Eisen A, Mackenzie IR
Muscle Nerve. 2010
PubMed ID: 20544928
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A
Exp Hematol. 2010
PubMed ID: 20412831
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20624952
Caudate atrophy on MRI is a characteristic feature of FTLD-FUS.
Josephs KA, Whitwell JL, Parisi JE, Petersen RC, Boeve BF, Jack CR, Dickson DW
Eur J Neurol. 2010
PubMed ID: 20236174
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.
Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T
Ann Neurol. 2010
PubMed ID: 20517935
FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS.
Tsai CP, Soong BW, Lin KP, Tu PH, Lin JL, Lee YC
Neurobiol Aging. 2010
PubMed ID: 20472325
De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis.
DeJesus-Hernandez M, Kocerha J, Finch N, Crook R, Baker M, Desaro P, Johnston A, Rutherford N, Wojtas A, Kennelly K, Wszolek ZK, Graff-Radford N, Boylan K, Rademakers R
Hum Mutat. 2010
PubMed ID: 20232451
Pigpen, a nuclear coiled body component protein, is involved in angiogenesis.
Yoshida T, Sato Y, Morita I, Abe M
Cancer Sci. 2010
PubMed ID: 20148893
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis.
Hewitt C, Kirby J, Highley JR, Hartley JA, Hibberd R, Hollinger HC, Williams TL, Ince PG, McDermott CJ, Shaw PJ
Arch Neurol. 2010
PubMed ID: 20385912
FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.
Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y
J Hum Genet. 2010
PubMed ID: 20224596
Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation.
Tateishi T, Hokonohara T, Yamasaki R, Miura S, Kikuchi H, Iwaki A, Tashiro H, Furuya H, Nagara Y, Ohyagi Y, Nukina N, Iwaki T, Fukumaki Y, Kira J
Acta Neuropathol. 2010
PubMed ID: 19967541
Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.
Corrado L, Del Bo R, Castellotti B, Ratti A, Cereda C, Penco S, Sorarù G, Carlomagno Y, Ghezzi S, Pensato V, Colombrita C, Gagliardi S, Cozzi L, Orsetti V, Mancuso M, Siciliano G, Mazzini L, Comi GP, Gellera C, Ceroni M, D'Alfonso S, Silani V
J Med Genet. 2010
PubMed ID: 19861302
Genetic contribution of FUS to frontotemporal lobar degeneration.
Van Langenhove T, van der Zee J, Sleegers K, Engelborghs S, Vandenberghe R, Gijselinck I, Van den Broeck M, Mattheijssens M, Peeters K, De Deyn PP, Cruts M, Van Broeckhoven C
Neurology. 2010
PubMed ID: 20124201
Specificity of fusion genes in adipocytic tumors.
Kubo T, Matsui Y, Naka N, Araki N, Myoui A, Endo K, Yasui N, Ohtani O, Suzuki K, Kimura T, Yoshikawa H, Ueda T
Anticancer Res. 2010
PubMed ID: 20332486
FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands.
Groen EJ, van Es MA, van Vught PW, Spliet WG, van Engelen-Lee J, de Visser M, Wokke JH, Schelhaas HJ, Ophoff RA, Fumoto K, Pasterkamp RJ, Dooijes D, Cuppen E, Veldink JH, van den Berg LH
Arch Neurol. 2010
PubMed ID: 20142531
FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis.
Broustal O, Camuzat A, Guillot-Noël L, Guy N, Millecamps S, Deffond D, Lacomblez L, Golfier V, Hannequin D, Salachas F, Camu W, Didic M, Dubois B, Meininger V, Le Ber I, Brice A, French clinical and genetic research network on FTD/FTD-MND
J Alzheimers Dis. 2010
PubMed ID: 21158017
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovée JV
Mol Cancer. 2010
PubMed ID: 20863376
Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
Huang C, Xia PY, Zhou H
Int J Biol Sci. 2010
PubMed ID: 20616880
FUS/TLS genetic variability in sporadic frontotemporal lobar degeneration.
Cantoni C, Fenoglio C, Cortini F, Venturelli E, Villa C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Scalabrini D, Franceschi M, Cappa S, Binetti G, Mariani C, Rainero I, Giordana MT, Bresolin N, Scarpini E, Galimberti D
J Alzheimers Dis. 2010
PubMed ID: 20061612
TLS inhibits RNA polymerase III transcription.
Tan AY, Manley JL
Mol Cell Biol. 2010
PubMed ID: 19841068
C-terminal FUS/TLS mutations in familial and sporadic ALS in Germany.
Drepper C, Herrmann T, Wessig C, Beck M, Sendtner M
Neurobiol Aging. 2009
PubMed ID: 20018407
FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis.
Blair IP, Williams KL, Warraich ST, Durnall JC, Thoeng AD, Manavis J, Blumbergs PC, Vucic S, Kiernan MC, Nicholson GA
J Neurol Neurosurg Psychiatry. 2009
PubMed ID: 19965854
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALS.
Damme PV, Goris A, Race V, Hersmus N, Dubois B, Bosch LV, Matthijs G, Robberecht W
Eur J Neurol. 2009
PubMed ID: 19922450
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR
Brain. 2009
PubMed ID: 19674978
Abundant FUS-immunoreactive pathology in neuronal intermediate filament inclusion disease.
Neumann M, Roeber S, Kretzschmar HA, Rademakers R, Baker M, Mackenzie IR
Acta Neuropathol. 2009
PubMed ID: 19669651
Mutations in FUS cause FALS and SALS in French and French Canadian populations.
Belzil VV, Valdmanis PN, Dion PA, Daoud H, Kabashi E, Noreau A, Gauthier J, S2D team, Hince P, Desjarlais A, Bouchard JP, Lacomblez L, Salachas F, Pradat PF, Camu W, Meininger V, Dupré N, Rouleau GA
Neurology. 2009
PubMed ID: 19741216
Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort.
Ticozzi N, Silani V, LeClerc AL, Keagle P, Gellera C, Ratti A, Taroni F, Kwiatkowski TJ, McKenna-Yasek DM, Sapp PC, Brown RH, Landers JE
Neurology. 2009
PubMed ID: 19741215
A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.
Takarada T, Tamaki K, Takumi T, Ogura M, Ito Y, Nakamichi N, Yoneda Y
J Neurochem. 2009
PubMed ID: 19558455
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.
Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH
Dev Biol. 2009
PubMed ID: 19501082
Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation.
Chiò A, Restagno G, Brunetti M, Ossola I, Calvo A, Mora G, Sabatelli M, Monsurrò MR, Battistini S, Mandrioli J, Salvi F, Spataro R, Schymick J, Traynor BJ, La Bella V, ITALSGEN Consortium
Neurobiol Aging. 2009
PubMed ID: 19450904
Identification of potentially damaging amino acid substitutions leading to human male infertility.
Kuzmin A, Jarvi K, Lo K, Spencer L, Chow GY, Macleod G, Wang Q, Varmuza S
Biol Reprod. 2009
PubMed ID: 19369647
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Rethinking ALS: the FUS about TDP-43.
Lagier-Tourenne C, Cleveland DW
Cell. 2009
PubMed ID: 19303844
Structural basis and specificity of human otubain 1-mediated deubiquitination.
Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM
Biochem J. 2009
PubMed ID: 18954305
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE
Science. 2009
PubMed ID: 19251628
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Kwiatkowski TJ, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH
Science. 2009
PubMed ID: 19251627
TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5.
Selamat W, Jamari I, Wang Y, Takumi T, Wong F, Fujii R
Neurosci Lett. 2009
PubMed ID: 19103256
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
Göransson M, Andersson MK, Forni C, Ståhlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
Oncogene. 2009
PubMed ID: 18850010
DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2.
Bento C, Andersson MK, Aman P
BMC Cell Biol. 2009
PubMed ID: 20017906
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization.
Sugita S, Seki K, Yokozawa K, Tochigi N, Furuta K, Hisaoka M, Hashimoto H, Shimoda T, Hasegawa T
Cancer Sci. 2009
PubMed ID: 19037998
Identification and characterization of FUS/TLS as a new target of ATM.
Gardiner M, Toth R, Vandermoere F, Morrice NA, Rouse J
Biochem J. 2008
PubMed ID: 18620545
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.
Goulet I, Boisvenue S, Mokas S, Mazroui R, Côté J
Hum Mol Genet. 2008
PubMed ID: 18632687
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.
Wang X, Arai S, Song X, Reichart D, Du K, Pascual G, Tempst P, Rosenfeld MG, Glass CK, Kurokawa R
Nature. 2008
PubMed ID: 18509338
TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells.
Pan J, Zou J, Wu DY, Roberson RS, Hennings LJ, Ma X, Yared M, Blackburn ML, Chansky HA, Yang L
Mol Cancer Res. 2008
PubMed ID: 18505930
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, Nukina N
J Biol Chem. 2008
PubMed ID: 18167354
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
Cironi L, Riggi N, Provero P, Wolf N, Suvà ML, Suvà D, Kindler V, Stamenkovic I
PLoS ONE. 2008
PubMed ID: 18648544
The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.
Andersson MK, Ståhlberg A, Arvidsson Y, Olofsson A, Semb H, Stenman G, Nilsson O, Aman P
BMC Cell Biol. 2008
PubMed ID: 18620564
Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins.
Shiohama A, Sasaki T, Noda S, Minoshima S, Shimizu N
Exp Cell Res. 2007
PubMed ID: 17765891
Fat-specific FUS-DDIT3-transgenic mice establish PPARgamma inactivation is required to liposarcoma development.
Pérez-Mancera PA, Vicente-Dueñas C, González-Herrero I, Sánchez-Martín M, Flores-Corral T, Sánchez-García I
Carcinogenesis. 2007
PubMed ID: 17468515
Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Gro
Guillou L, Benhattar J, Gengler C, Gallagher G, Ranchère-Vince D, Collin F, Terrier P, Terrier-Lacombe MJ, Leroux A, Marquès B, Aubain Somerhausen Nde S, Keslair F, Pedeutour F, Coindre JM
Am J Surg Pathol. 2007
PubMed ID: 17721195
Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
Sugiura T, Sakurai K, Nagano Y
Exp Cell Res. 2007
PubMed ID: 17196963
System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock.
Kornmann B, Schaad O, Bujard H, Takahashi JS, Schibler U
PLoS Biol. 2007
PubMed ID: 17298173
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Ballif BA, Cao Z, Schwartz D, Carraway KL, Gygi SP
J Proteome Res. 2006
PubMed ID: 16944949
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.
Engström K, Willén H, Kåbjörn-Gustafsson C, Andersson C, Olsson M, Göransson M, Järnum S, Olofsson A, Warnhammar E, Aman P
Am J Pathol. 2006
PubMed ID: 16651630
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases.
Radic MZ, Shah K, Zhang W, Lu Q, Lemke G, Hilliard GM
J Immunol. 2006
PubMed ID: 16365397
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines.
Fujii R, Takumi T
J Cell Sci. 2005
PubMed ID: 16317045
beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.
Sato S, Idogawa M, Honda K, Fujii G, Kawashima H, Takekuma K, Hoshika A, Hirohashi S, Yamada T
Gastroenterology. 2005
PubMed ID: 16230076
[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]
He J, Chen ZX, Xue YQ, Li JQ, He HL, Huang YP, He YX, Chai YH, Zhu LL
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 16215946
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease.
Kasyapa CS, Kunapuli P, Cowell JK
Exp Cell Res. 2005
PubMed ID: 15975576
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
WW domains provide a platform for the assembly of multiprotein networks.
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T
Mol Cell Biol. 2005
PubMed ID: 16055720
The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts.
Zou J, Ichikawa H, Blackburn ML, Hu HM, Zielinska-Kwiatkowska A, Mei Q, Roth GJ, Chansky HA, Yang L
Mol Cell Biol. 2005
PubMed ID: 15988032
Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
Göransson M, Elias E, Ståhlberg A, Olofsson A, Andersson C, Aman P
Int J Cancer. 2005
PubMed ID: 15688424
The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology.
Fujii R, Okabe S, Urushido T, Inoue K, Yoshimura A, Tachibana T, Nishikawa T, Hicks GG, Takumi T
Curr Biol. 2005
PubMed ID: 15797031
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA
BMC Dev Biol. 2005
PubMed ID: 16033648
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF).
Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA
Development. 2005
PubMed ID: 15604097
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
The sequence and analysis of duplication-rich human chromosome 16.
Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA
Nature. 2004
PubMed ID: 15616553
A neurogenomics approach to gene expression analysis in the developing brain.
Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T
Brain Res Mol Brain Res. 2004
PubMed ID: 15582152
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
Ong SE, Mittler G, Mann M
Nat Methods. 2004
PubMed ID: 15782174
Domain architectures and characterization of an RNA-binding protein, TLS.
Iko Y, Kodama TS, Kasai N, Oyama T, Morita EH, Muto T, Okumura M, Fujii R, Takumi T, Tate S, Morikawa K
J Biol Chem. 2004
PubMed ID: 15299008
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Comparable transforming capacities and differential gene expression patterns of variant FUS/CHOP fusion transcripts derived from soft tissue liposarcomas.
Schwarzbach MH, Koesters R, Germann A, Mechtersheimer G, Geisbill J, Winkler S, Niedergethmann M, Ridder R, Buechler MW, von Knebel Doeberitz M, Willeke F
Oncogene. 2004
PubMed ID: 15286712
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Fusion of the FUS and BBF2H7 genes in low grade fibromyxoid sarcoma.
Storlazzi CT, Mertens F, Nascimento A, Isaksson M, Wejde J, Brosjo O, Mandahl N, Panagopoulos I
Hum Mol Genet. 2003
PubMed ID: 12915480
Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis.
Alappat SR, Zhang M, Zhao X, Alliegro MA, Alliegro MC, Burdsal CA
Dev Dyn. 2003
PubMed ID: 12950080
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis.
Sapp PC, Hosler BA, McKenna-Yasek D, Chin W, Gann A, Genise H, Gorenstein J, Huang M, Sailer W, Scheffler M, Valesky M, Haines JL, Pericak-Vance M, Siddique T, Horvitz HR, Brown RH
Am J Hum Genet. 2003
PubMed ID: 12858291
Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q.
Ruddy DM, Parton MJ, Al-Chalabi A, Lewis CM, Vance C, Smith BN, Leigh PN, Powell JF, Siddique T, Meyjes EP, Baas F, de Jong V, Shaw CE
Am J Hum Genet. 2003
PubMed ID: 12840784
A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2.
Abalkhail H, Mitchell J, Habgood J, Orrell R, de Belleroche J
Am J Hum Genet. 2003
PubMed ID: 12830400
Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode.
Rappsilber J, Friesen WJ, Paushkin S, Dreyfuss G, Mann M
Anal Chem. 2003
PubMed ID: 12964758
Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins.
Meissner M, Lopato S, Gotzmann J, Sauermann G, Barta A
Exp Cell Res. 2003
PubMed ID: 12581738
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Comprehensive proteomic analysis of the human spliceosome.
Zhou Z, Licklider LJ, Gygi SP, Reed R
Nature. 2002
PubMed ID: 12226669
Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy.
Wada K, Inoue K, Hagiwara M
Biochim Biophys Acta. 2002
PubMed ID: 12183049
Temperature-dependent localization of TLS-CHOP to splicing factor compartments.
Göransson M, Wedin M, Aman P
Exp Cell Res. 2002
PubMed ID: 12169268
RNA splicing mediated by YB-1 is inhibited by TLS/CHOP in human myxoid liposarcoma cells.
Rapp TB, Yang L, Conrad EU, Mandahl N, Chansky HA
J Orthop Res. 2002
PubMed ID: 12168660
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays.
Lee J, Bedford MT
EMBO Rep. 2002
PubMed ID: 11850402
Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR.
Saunders LR, Perkins DJ, Balachandran S, Michaels R, Ford R, Mayeda A, Barber GN
J Biol Chem. 2001
PubMed ID: 11438536
Characterization of a new brain-specific isoform of the EWS oncoprotein.
Melot T, Dauphinot L, Sévenet N, Radvanyi F, Delattre O
Eur J Biochem. 2001
PubMed ID: 11422378
Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator.
Uranishi H, Tetsuka T, Yamashita M, Asamitsu K, Shimizu M, Itoh M, Okamoto T
J Biol Chem. 2001
PubMed ID: 11278855
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.
Waters BL, Panagopoulos I, Allen EF
Cancer Genet Cytogenet. 2000
PubMed ID: 11063792
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG
Nat Neurosci. 2000
PubMed ID: 10862698
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins.
Yang L, Embree LJ, Hickstein DD
Mol Cell Biol. 2000
PubMed ID: 10779324
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE
Nat Genet. 2000
PubMed ID: 10655065
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice.
Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooij DG, Akhmedov A, Ashley T, Ron D
EMBO J. 2000
PubMed ID: 10654943
Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation.
Baechtold H, Kuroda M, Sok J, Ron D, Lopez BS, Akhmedov AT
J Biol Chem. 1999
PubMed ID: 10567410
Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.
Bertrand P, Akhmedov AT, Delacote F, Durrbach A, Lopez BS
Oncogene. 1999
PubMed ID: 10442642
Induction of a secreted protein by the myxoid liposarcoma oncogene.
Kuroda M, Wang X, Sok J, Yin Y, Chung P, Giannotti JW, Jacobs KA, Fitz LJ, Murtha-Riel P, Turner KJ, Ron D
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10220412
Characterization of TFG in mus musculus and Caenorhabditis elegans.
Mencinger M, Aman P
Biochem Biophys Res Commun. 1999
PubMed ID: 10092511
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M
Gene. 1998
PubMed ID: 9795213
Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.
Yang L, Embree LJ, Tsai S, Hickstein DD
J Biol Chem. 1998
PubMed ID: 9774382
The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
Zhang D, Paley AJ, Childs G
J Biol Chem. 1998
PubMed ID: 9660765
The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS.
Hallier M, Lerga A, Barnache S, Tavitian A, Moreau-Gachelin F
J Biol Chem. 1998
PubMed ID: 9478924
TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors.
Powers CA, Mathur M, Raaka BM, Ron D, Samuels HH
Mol Endocrinol. 1998
PubMed ID: 9440806
TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling.
Zinszner H, Sok J, Immanuel D, Yin Y, Ron D
J Cell Sci. 1997
PubMed ID: 9264461
Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
Aman P, Panagopoulos I, Lassen C, Fioretos T, Mencinger M, Toresson H, Höglund M, Forster A, Rabbitts TH, Ron D, Mandahl N, Mitelman F
Genomics. 1996
PubMed ID: 8921363
Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation.
Panagopoulos I, Mandahl N, Ron D, Höglund M, Nilbert M, Mertens F, Mitelman F, Aman P
Cancer Res. 1994
PubMed ID: 7987849
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
Ichikawa H, Shimizu K, Hayashi Y, Ohki M
Cancer Res. 1994
PubMed ID: 8187069
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
Crozat A, Aman P, Mandahl N, Ron D
Nature. 1993
PubMed ID: 8510758
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
Rabbitts TH, Forster A, Larson R, Nathan P
Nat Genet. 1993
PubMed ID: 7503811
Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.
Eneroth M, Mandahl N, Heim S, Willén H, Rydholm A, Alberts KA, Mitelman F
Cancer Genet Cytogenet. 1990
PubMed ID: 2372777

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2521	233908	317385
EnsEMBL Gene(s)	ENSG00000089280	ENSMUSG00000030795	ENSRNOG00000023360
Unigene	Hs.46894	Mm.277680	Rn.100218
Homologene	FUS	Fus	Fus
OMIM	137070	N/A	N/A
GeneCards	FUS	N/A	N/A
Beta Cell Genomics	DT.100876810 DT.100876813 DT.100876816 DT.100876817 DT.100876818 DT.120687255 DT.120687296 DT.120687314 DT.448733 DT.95305442 DT.95338699	DT.101284696 DT.102548704 DT.110981358 DT.110981609 DT.110981648 DT.110981722 DT.50317164 DT.87071465 DT.91580339 DT.94377880 DT.94390620	N/A
Reactome	P35637	N/A	N/A
Plasma Peptide Atlas	ENSP00000254108	N/A	N/A
WikiGenes	2521	233908	317385

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
FUS	RBM5	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	ALYREF	Reactome	predicted	12176931 11991638 12477934
FUS	HNRNPR	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	SRRM1	HPRD, BioGRID, Reactome	empirical	12581738 12176931 11991638 12477934
FUS	EIF1B	IntAct	empirical	17353931
FUS	TNIP1	IntAct	empirical	21988832
FUS	CD2BP2	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	KHDRBS3	IntAct	empirical	21988832
FUS	SRSF10	HPRD, MINT, BioGRID	empirical	10779324 9774382
FUS	HNRNPA0	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPUL1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	WBP4	MINT, BioGRID	empirical	16055720
FUS	GABARAP	IntAct	empirical	20562859
FUS	U2AF2	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	GABARAPL2	IntAct	empirical	20562859
FUS	DHX9	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	ESR1	IntAct	empirical	21182205
FUS	ESRRA	IntAct	empirical	21988832
FUS	EWSR1	IntAct	empirical	21988832
FUS	HNRNPA3	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	DNAJC8	Reactome	predicted	12176931 11991638 6088074 6206566
FUS	PDS5A	IntAct, BioGRID	empirical	20360068
FUS	RPGRIP1L	IntAct	empirical	21565611
FUS	TARDBP	BioGRID	empirical	20720006
FUS	GABARAPL1	IntAct	empirical	20562859
FUS	FUS	HPRD	empirical	9774382
FUS	RBMX	IntAct, Reactome	empirical	21988832 12176931 12477934 6088074 6206566
FUS	GRB2	IntAct	empirical	19380743
FUS	GRIN1	HPRD, MINT, IntAct	empirical	10862698 16635246
FUS	GRIN2B	IntAct	empirical	10862698
FUS	GRIN2D	HPRD	empirical	10862698
FUS	GSK3B	IntAct	empirical	17353931
FUS	HLA-B	IntAct	empirical	17353931
FUS	HNRNPA1	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPA2B1	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPC	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPD	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPF	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPH1	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPH2	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPK	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPL	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	HNRNPU	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	PRMT1	HPRD, MINT, IntAct, BioGRID	empirical	11850402 16169070 12183049
FUS	ILF3	HPRD	empirical	11438536
FUS	EIF6	IntAct	empirical	17353931
FUS	ARHGDIA	IntAct	empirical	17353931
FUS	MAGEB2	IntAct	empirical	17353931
FUS	MAX	IntAct	empirical	20195357
FUS	MDH1	IntAct	empirical	21988832
FUS	HNRNPM	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	NFX1	Reactome	predicted	12176931 11991638 12477934
FUS	YBX1	HPRD, BioGRID, Reactome	empirical	12168660 12176931 11991638 12477934 6088074 6206566
FUS	PCBP1	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	PCBP2	Reactome	predicted	12176931 12477934 6088074 6206566
FUS	PCM1	BioGRID	empirical	21956701
FUS	CDC40	Reactome	predicted	12176931 11991638 6088074 6206566
FUS	POLR2A	HPRD	empirical	12168660
FUS	DGCR8	BioGRID	empirical	17765891
FUS	OTUB1	BioGRID	empirical	18954305
FUS	LYAR	IntAct	empirical	17353931
FUS	CCAR1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	MAPK13	IntAct, BioGRID	empirical	19135240
FUS	PSMB7	IntAct	empirical	21988832
FUS	PTBP1	HPRD, Reactome	empirical	12581738 12176931 12477934 6088074 6206566
FUS	SUGP1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	PTBP2	BioGRID	empirical	12581738
FUS	RELA	HPRD, BioGRID	empirical	11278855
FUS	RXRA	HPRD, BioGRID	empirical	9440806
FUS	SFPQ	HPRD, MINT	empirical	15975576
FUS	SRSF1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	SRSF2	HPRD, MINT, BioGRID, Reactome	empirical	9774382 12176931 11991638 12477934 6088074 6206566
FUS	SRSF3	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	SRSF4	HPRD, Reactome	empirical	12581738 12176931 11991638 6088074 6206566
FUS	SRSF5	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	SRSF6	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	SRSF7	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	SPI1	HPRD, BioGRID	empirical	9478924
FUS	THRA	HPRD, BioGRID	empirical	9440806
FUS	U2AF1	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	UBC	BioGRID	empirical	22178446 21139048 21890473 21906983
FUS	USF2	IntAct, BioGRID	empirical	17353931
FUS	YWHAE	BioGRID	empirical	16944949
FUS	SF1	HPRD, BioGRID	empirical	9660765
FUS	ZMYM2	HPRD, MINT	empirical	15975576
FUS	CCDC15	IntAct, BioGRID	empirical	20360068
FUS	SHOC2	IntAct, BioGRID	empirical	20360068
FUS	TAF15	IntAct	empirical	21988832
FUS	TDRD3	IntAct	empirical	21988832
FUS	MAP1LC3B	IntAct	empirical	20562859
FUS	SF3A2	MINT	empirical	17332742
FUS	SMC1A	Reactome	predicted	12176931 11991638 12477934 6088074 6206566
FUS	BCAR3	IntAct	empirical	17353931
FUS	SARNP	BioGRID	empirical	17196963
FUS	MAP1LC3A	IntAct	empirical	20562859
FUS	NKD2	IntAct	empirical	21988832
FUS	TP63	IntAct	empirical	20085233
FUS	SRSF9	IntAct, Reactome	empirical	21988832 12176931 11991638 12477934 6088074 6206566
FUS	SRSF11	Reactome	predicted	12176931 11991638 6088074 6206566
FUS	SAFB2	IntAct	empirical	21988832
FUS	KIAA0101	BioGRID	empirical	21628590
FUS	DHX38	Reactome	predicted	12176931 11991638 6088074 6206566