ALOX5

Summary Top Help

Gene Description:

arachidonate 5-lipoxygenase

Synonyms:

5LPG, 5LO, LOG5, ALOX5, LOX5A, Alox5, AI850497, F730011J02, 5-LO, 5-LOX, 5LX

Orthologs:

Human ALOX5 (protein-coding), Mouse Alox5 (protein-coding), Rat Alox5 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr10:45869629..45941565 (71.94 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:116360089..116411196 (51.11 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:152610283..152657891 (47.61 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ALOX5:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ALOX5:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 1

Reactome: 4

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 29

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 364

The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions.
Walther M, Hofheinz K, Vogel R, Roffeis J, Kühn H
Arch Biochem Biophys. 2011
PubMed ID: 21951814
Two dimensional difference gel electrophoresis analysis of cerebrospinal fluid in tuberculous meningitis patients.
Kataria J, Rukmangadachar LA, Hariprasad G, O J, Tripathi M, Srinivasan A
J Proteomics. 2011
PubMed ID: 21723968
A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia.
Chen Y, Sullivan C, Peng C, Shan Y, Hu Y, Li D, Li S
Blood. 2011
PubMed ID: 21596859
Molecular basis for the reduced catalytic activity of the naturally occurring T560M mutant of human 12/15-lipoxygenase that has been implicated in coronary artery disease.
Schurmann K, Anton M, Ivanov I, Richter C, Kuhn H, Walther M
J Biol Chem. 2011
PubMed ID: 21558275
Increased Δ5- and Δ6-desaturase, cyclooxygenase-2, and lipoxygenase-5 expression and activity are associated with fatty acid and eicosanoid changes in cystic fibrosis.
Njoroge SW, Seegmiller AC, Katrangi W, Laposata M
Biochim Biophys Acta. 2011
PubMed ID: 21605700
Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage.
Yoshikawa K, Palumbo S, Toscano CD, Bosetti F
Prostaglandins Leukot Essent Fatty Acids. 2011
PubMed ID: 21555210
Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity.
Shen M, Zhang L, Lee KM, Vermeulen R, Hosgood HD, Li G, Yin S, Rothman N, Chanock S, Smith MT, Lan Q
Exp Mol Med. 2011
PubMed ID: 21540635
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Leukotriene B4 mediates neutrophil migration induced by heme.
Monteiro AP, Pinheiro CS, Luna-Gomes T, Alves LR, Maya-Monteiro CM, Porto BN, Barja-Fidalgo C, Benjamim CF, Peters-Golden M, Bandeira-Melo C, Bozza MT, Canetti C
J Immunol. 2011
PubMed ID: 21536805
ALOX5 gene variants affect eicosanoid production and response to fish oil supplementation.
Stephensen CB, Armstrong P, Newman JW, Pedersen TL, Legault J, Schuster GU, Kelley D, Vikman S, Hartiala J, Nassir R, Seldin MF, Allayee H
J Lipid Res. 2011
PubMed ID: 21296957
Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways.
Griesser M, Suzuki T, Tejera N, Mont S, Boeglin WE, Pozzi A, Schneider C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21482803
Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an alzheimer's disease transgenic mouse model involvement of γ-secretase.
Chu J, Praticò D
Am J Pathol. 2011
PubMed ID: 21435457
Upregulation of the 5-lipoxygenase pathway in human aortic valves correlates with severity of stenosis and leads to leukotriene-induced effects on valvular myofibroblasts.
Nagy E, Andersson DC, Caidahl K, Eriksson MJ, Eriksson P, Franco-Cereceda A, Hansson GK, Bäck M
Circulation. 2011
PubMed ID: 21403093
[5-lipoxygenase is involved in rotenone-induced injury in PC12 cells].
Zhang XY, Zhang LH, Li CT, Chen WJ, Zhao JB, Wei EQ
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011
PubMed ID: 21488210
5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.
Blaho VA, Zhang Y, Hughes-Hanks JM, Brown CR
J Immunol. 2011
PubMed ID: 21270404
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Cheon EC, Khazaie K, Khan MW, Strouch MJ, Krantz SB, Phillips J, Blatner NR, Hix LM, Zhang M, Dennis KL, Salabat MR, Heiferman M, Grippo PJ, Munshi HG, Gounaris E, Bentrem DJ
Cancer Res. 2011
PubMed ID: 21216893
Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.
Ha YJ, Seul HJ, Lee JR
Exp Mol Med. 2011
PubMed ID: 21200133
5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids.
Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE
Sci Transl Med. 2011
PubMed ID: 21307302
Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression.
Serezani CH, Lewis C, Jancar S, Peters-Golden M
J Clin Invest. 2011
PubMed ID: 21206089
The structure of human 5-lipoxygenase.
Gilbert NC, Bartlett SG, Waight MT, Neau DB, Boeglin WE, Brash AR, Newcomer ME
Science. 2011
PubMed ID: 21233389
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.
Puccio S, Chu J, Praticò D
PLoS One. 2011
PubMed ID: 21253592
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.
Nagashima T, Ichimiya S, Kikuchi T, Saito Y, Matsumiya H, Ara S, Koshiba S, Zhang J, Hatate C, Tonooka A, Kubo T, Ye RC, Hirose B, Shirasaki H, Izumi T, Takami T, Himi T, Sato N
Am J Pathol. 2011
PubMed ID: 21224059
Interaction of ceruloplasmin and 5-lipoxygenase.
Sokolov AV, Golenkina EA, Kostevich VA, Vasilyev VB, Sud'ina GF
Biochemistry (Mosc). 2010
PubMed ID: 21314617
5-Lipoxygenase in mouse cerebellar Purkinje cells.
Chen H, Dzitoyeva S, Manev H
Neuroscience. 2010
PubMed ID: 20851170
Interplay of cysteinyl leukotrienes and TGF-β in the activation of hepatic stellate cells from Schistosoma mansoni granulomas.
Paiva LA, Maya-Monteiro CM, Bandeira-Melo C, Silva PM, El-Cheikh MC, Teodoro AJ, Borojevic R, Perez SA, Bozza PT
Biochim Biophys Acta. 2010
PubMed ID: 20817008
Novel 5-lipoxygenase isoforms affect the biosynthesis of 5-lipoxygenase products.
Boudreau LH, Bertin J, Robichaud PP, Laflamme M, Ouellette RJ, Flamand N, Surette ME
FASEB J. 2010
PubMed ID: 21098726
Flavocoxid, a dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis.
Polito F, Bitto A, Irrera N, Squadrito F, Fazzari C, Minutoli L, Altavilla D
Br J Pharmacol. 2010
PubMed ID: 20977452
Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis.
Chen M, Lam BK, Luster AD, Zarini S, Murphy RC, Bair AM, Soberman RJ, Lee DM
J Immunol. 2010
PubMed ID: 20876351
HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages.
Lee SJ, Kim CE, Seo KW, Kim CD
Cardiovasc Res. 2010
PubMed ID: 20554538
Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier.
Zhu L, Maruvada R, Sapirstein A, Malik KU, Peters-Golden M, Kim KS
Infect Immun. 2010
PubMed ID: 20696828
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group
Diabetes. 2010
PubMed ID: 20682687
An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Hum Genet. 2010
PubMed ID: 20677014
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Zileuton reduces inflammatory reaction and brain damage following permanent cerebral ischemia in rats.
Tu XK, Yang WZ, Wang CH, Shi SS, Zhang YL, Chen CM, Yang YK, Jin CD, Wen S
Inflammation. 2010
PubMed ID: 20204486
Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies.
Obrosova IG, Stavniichuk R, Drel VR, Shevalye H, Vareniuk I, Nadler JL, Schmidt RE
Am J Pathol. 2010
PubMed ID: 20724598
Anti-atherogenic effect of BHB-TZD having inhibitory activities on cyclooxygenase and 5-lipoxygenase in hyperlipidemic mice.
Choi JH, Jeon HJ, Park JG, Sonn SK, Lee MR, Lee MN, You HJ, Kim GY, Kim JH, Lee MH, Kwon OS, Nam KH, Kim HC, Jeong TS, Lee WS, Oh GT
Atherosclerosis. 2010
PubMed ID: 20684827
Overexpression of 5-lipoxygenase in sporadic colonic adenomas and a possible new aspect of colon carcinogenesis.
Wasilewicz MP, Kołodziej B, Bojułko T, Kaczmarczyk M, Sulzyc-Bielicka V, Bielicki D, Ciepiela K
Int J Colorectal Dis. 2010
PubMed ID: 20549218
Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis.
Divangahi M, Desjardins D, Nunes-Alves C, Remold HG, Behar SM
Nat Immunol. 2010
PubMed ID: 20622882
5-lipoxygenase is a key determinant of acute myocardial inflammation and mortality during Trypanosoma cruzi infection.
Pavanelli WR, Gutierrez FR, Mariano FS, Prado CM, Ferreira BR, Teixeira MM, Canetti C, Rossi MA, Cunha FQ, Silva JS
Microbes Infect. 2010
PubMed ID: 20381637
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D
Hum Immunol. 2010
PubMed ID: 20438785
mRNA levels of enzymes and receptors implicated in arachidonic acid metabolism in gliomas.
De Armas R, Durand K, Guillaudeau A, Weinbreck N, Robert S, Moreau JJ, Caire F, Acosta G, Pebet M, Chaunavel A, Marin B, Labrousse F, Denizot Y
Clin Biochem. 2010
PubMed ID: 20382140
5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase.
Yun MR, Park HM, Seo KW, Lee SJ, Im DS, Kim CD
Free Radic Res. 2010
PubMed ID: 20370567
Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy.
Khan M, Singh J, Gilg AG, Uto T, Singh I
J Lipid Res. 2010
PubMed ID: 20173212
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
Protection from hepatic lipid accumulation and inflammation by genetic ablation of 5-lipoxygenase.
Titos E, Ferré N, Lozano JJ, Horrillo R, López-Parra M, Arroyo V, Clària J
Prostaglandins Other Lipid Mediat. 2010
PubMed ID: 20227514
Risk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20406964
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.
Lepage C, Liagre B, Cook-Moreau J, Pinon A, Beneytout JL
Int J Oncol. 2010
PubMed ID: 20372792
Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia.
Mancuso P, Lewis C, Serezani CH, Goel D, Peters-Golden M
Infect Immun. 2010
PubMed ID: 20231413
Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow.
Queto T, Gaspar-Elsas MI, Masid-de-Brito D, Vasconcelos ZF, Ferraris FK, Penido C, Cunha FQ, Kanaoka Y, Lam BK, Xavier-Elsas P
J Leukoc Biol. 2010
PubMed ID: 20219953
Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Int J Mol Med. 2010
PubMed ID: 20198315
The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells.
Finkensieper A, Kieser S, Bekhite MM, Richter M, Mueller JP, Graebner R, Figulla HR, Sauer H, Wartenberg M
Cardiovasc Res. 2010
PubMed ID: 19965960
A mutant of HBx (HBxDelta127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase.
Wang Q, Zhang WY, Ye LH, Zhang XD
Acta Pharmacol Sin. 2010
PubMed ID: 20173757
Genome-wide association study of hematological and biochemical traits in a Japanese population.
Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N
Nat Genet. 2010
PubMed ID: 20139978
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, Zhang X
Neoplasia. 2010
PubMed ID: 20126469
Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
Burdon KP, Rudock ME, Lehtinen AB, Langefeld CD, Bowden DW, Register TC, Liu Y, Freedman BI, Carr JJ, Hedrick CC, Rich SS
Mediators Inflamm. 2010
PubMed ID: 20592751
A pilot study on prostate cancer risk and pro-inflammatory genotypes: pathophysiology and therapeutic implications.
Balistreri CR, Caruso C, Carruba G, Miceli V, Campisi I, Listì F, Lio D, Colonna-Romano G, Candore G
Curr Pharm Des. 2010
PubMed ID: 20388081
Role of cyclooxygenase-2 and 5-lipoxygenase polymorphisms in Alzheimer's disease in a population from northern Italy: implication for pharmacogenomics.
Listì F, Caruso C, Lio D, Colonna-Romano G, Chiappelli M, Licastro F, Candore G
J Alzheimers Dis. 2010
PubMed ID: 20110601
Endogenous LXA4 circuits are determinants of pathological angiogenesis in response to chronic injury.
Leedom AJ, Sullivan AB, Dong B, Lau D, Gronert K
Am J Pathol. 2010
PubMed ID: 20008149
Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Am J Hypertens. 2010
PubMed ID: 19851296
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.
Esser J, Rakonjac M, Hofmann B, Fischer L, Provost P, Schneider G, Steinhilber D, Samuelsson B, Rådmark O
Biochem J. 2010
PubMed ID: 19807693
5-Lipoxygenase and epigenetic DNA methylation in aging cultures of cerebellar granule cells.
Imbesi M, Dzitoyeva S, Ng LW, Manev H
Neuroscience. 2009
PubMed ID: 19778587
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
Functional analysis of 5-lipoxygenase promoter repeat variants.
Vikman S, Brena RM, Armstrong P, Hartiala J, Stephensen CB, Allayee H
Hum Mol Genet. 2009
PubMed ID: 19717473
Gastroprotective action of Cochinchina momordica seed extract is mediated by activation of CGRP and inhibition of cPLA(2)/5-LOX pathway.
Kang JM, Kim N, Kim B, Kim JH, Lee BY, Park JH, Lee MK, Lee HS, Jang IJ, Kim JS, Jung HC, Song IS
Dig Dis Sci. 2009
PubMed ID: 19130224
5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines.
Ishii K, Zaitsu M, Yonemitsu N, Kan Y, Hamasaki Y, Matsuo M
Clin Neuropathol. 2009
PubMed ID: 19919819
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Pharmacological inhibition of 5-lipoxygenase accelerates and enhances fracture-healing.
Cottrell JA, O'Connor JP
J Bone Joint Surg Am. 2009
PubMed ID: 19884440
Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P
J Immunol. 2009
PubMed ID: 19734227
Association of gene polymorphisms with chronic kidney disease in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Int J Mol Med. 2009
PubMed ID: 19724895
CJ-13610, an orally active inhibitor of 5-lipoxygenase is efficacious in preclinical models of pain.
Cortes-Burgos LA, Zweifel BS, Settle SL, Pufahl RA, Anderson GD, Hardy MM, Weir DE, Hu G, Happa FA, Stewart Z, Muthian S, Graneto MJ, Masferrer JL
Eur J Pharmacol. 2009
PubMed ID: 19580807
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y
Int J Mol Med. 2009
PubMed ID: 19578796
Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair.
Divangahi M, Chen M, Gan H, Desjardins D, Hickman TT, Lee DM, Fortune S, Behar SM, Remold HG
Nat Immunol. 2009
PubMed ID: 19561612
Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice.
Poeckel D, Zemski Berry KA, Murphy RC, Funk CD
J Biol Chem. 2009
PubMed ID: 19509298
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma.
Bizzintino JA, Khoo SK, Zhang G, Martin AC, Rueter K, Geelhoed GC, Goldblatt J, Laing IA, Le Souëf PN, Hayden CM
Prostaglandins Leukot Essent Fatty Acids. 2009
PubMed ID: 19524426
Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia.
Chen Y, Hu Y, Zhang H, Peng C, Li S
Nat Genet. 2009
PubMed ID: 19503090
5-Lipoxygenase-mediated endogenous DNA damage.
Jian W, Lee SH, Williams MV, Blair IA
J Biol Chem. 2009
PubMed ID: 19390118
Genotyping the GGGCGG tandem repeat promoter polymorphism in the 5-lipoxygenase enzyme gene (ALOX5) by pyrosequencing assay.
Schentrup AM, Allayee H, Lima JJ, Johnson JA, Langaee TY
Genet Test Mol Biomarkers. 2009
PubMed ID: 19473080
Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation.
Zarini S, Gijón MA, Ransome AE, Murphy RC, Sala A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19416808
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity.
York TP, Vargas-Irwin C, Anderson WH, van den Oord EJ
Pharmacogenomics. 2009
PubMed ID: 19450127
Functional variants of the human 5-lipoxygenase gene and their genetic diagnosis.
Geiger EV, Doehring A, Kirchhof A, Lötsch J
Prostaglandins Leukot Essent Fatty Acids. 2009
PubMed ID: 19446447
Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19423540
Analyses of associations with asthma in four asthma population samples from Canada and Australia.
Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Paré PD, Hudson TJ
Hum Genet. 2009
PubMed ID: 19247692
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.
Strid T, Svartz J, Franck N, Hallin E, Ingelsson B, Söderström M, Hammarström S
Biochem Biophys Res Commun. 2009
PubMed ID: 19233132
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production.
Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19289819
Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection.
Sorgi CA, Secatto A, Fontanari C, Turato WM, Belangér C, de Medeiros AI, Kashima S, Marleau S, Covas DT, Bozza PT, Faccioli LH
J Immunol. 2009
PubMed ID: 19299700
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice.
Cao RY, St Amand T, Gräbner R, Habenicht AJ, Funk CD
Atherosclerosis. 2009
PubMed ID: 18804760
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas' disease.
Borges CL, Cecchini R, Tatakihara VL, Malvezi AD, Yamada-Ogatta SF, Rizzo LV, Pinge-Filho P
Immunol Lett. 2009
PubMed ID: 19428550
5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci.
Tantisira KG, Lima J, Sylvia J, Klanderman B, Weiss ST
Pharmacogenet Genomics. 2009
PubMed ID: 19214143
4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase.
Yun MR, Im DS, Lee SJ, Park HM, Bae SS, Lee WS, Kim CD
Free Radic Biol Med. 2009
PubMed ID: 19135147
Genetic variation in the leukotriene pathway and carotid intima-media thickness: a 2-stage replication study.
Bevan S, Lorenz MW, Sitzer M, Markus HS
Stroke. 2009
PubMed ID: 19131661
Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
Crosslin DR, Shah SH, Nelson SC, Haynes CS, Connelly JJ, Gadson S, Goldschmidt-Clermont PJ, Vance JM, Rose J, Granger CB, Seo D, Gregory SG, Kraus WE, Hauser ER
Hum Genet. 2009
PubMed ID: 19130089
Lysophosphatidylcholine enhances oxidative stress via the 5-lipoxygenase pathway in rat aorta during aging.
Zou Y, Kim DH, Jung KJ, Heo HS, Kim CH, Baik HS, Yu BP, Yokozawa T, Chung HY
Rejuvenation Res. 2009
PubMed ID: 19226207
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.
Dincbas-Renqvist V, Pépin G, Rakonjac M, Plante I, Ouellet DL, Hermansson A, Goulet I, Doucet J, Samuelsson B, Rådmark O, Provost P
Biochim Biophys Acta. 2009
PubMed ID: 19022417
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
Flamand N, Luo M, Peters-Golden M, Brock TG
J Biol Chem. 2009
PubMed ID: 18978352
5-Lipoxygenase pathway gene polymorphisms: lack of association with asthma in a Spanish population.
Torres-Galván SM, Cumplido JA, Buset N, Caballero-Hidalgo A, Blanco C, Hernández E, Carrillo T
J Investig Allergol Clin Immunol. 2009
PubMed ID: 20128419
5-Lipoxygenase DNA methylation and mRNA content in the brain and heart of young and old mice.
Dzitoyeva S, Imbesi M, Ng LW, Manev H
Neural Plast. 2009
PubMed ID: 20052386
Cardioprotective effect of 5-lipoxygenase gene (ALOX5) silencing in ischemia-reperfusion.
Lisovyy OO, Dosenko VE, Nagibin VS, Tumanovska LV, Korol MO, Surova OV, Moibenko OO
Acta Biochim Pol. 2009
PubMed ID: 20011686
Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.
Andreotti G, Menashe I, Chen J, Chang SC, Rashid A, Gao YT, Han TQ, Sakoda LC, Chanock S, Rosenberg PS, Hsing AW
Eur J Epidemiol. 2009
PubMed ID: 19888660
Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.
Peskar BM, Ehrlich K, Schuligoi R, Peskar BA
Pharmacology. 2009
PubMed ID: 19816089
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.
Gheorghe KR, Korotkova M, Catrina AI, Backman L, af Klint E, Claesson HE, Rådmark O, Jakobsson PJ
Arthritis Res Ther. 2009
PubMed ID: 19497113
Effects of celecoxib and nordihydroguaiaretic acid on puromycin aminonucleoside-induced nephrosis in the rat.
Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Chung HC, Yang BY, Lee MY, Sol MY
J Korean Med Sci. 2009
PubMed ID: 19194550
Post-treatment effects of erythropoietin and nordihydroguaiaretic acid on recovery from cisplatin-induced acute renal failure in the rat.
Lee DW, Kwak IS, Lee SB, Song SH, Seong EY, Yang BY, Lee MY, Sol MY
J Korean Med Sci. 2009
PubMed ID: 19194548
High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes.
Mahshid Y, Lisy MR, Wang X, Spanbroek R, Flygare J, Christensson B, Björkholm M, Sander B, Habenicht AJ, Claesson HE
BMC Immunol. 2009
PubMed ID: 19134178
Inhaled carbenoxolone prevents allergic airway inflammation and airway hyperreactivity in a mouse model of asthma.
Ram A, Singh SK, Singh VP, Kumar S, Ghosh B
Int Arch Allergy Immunol. 2009
PubMed ID: 19033731
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.
Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O
J Med Chem. 2008
PubMed ID: 19053751
The nuclear membrane organization of leukotriene synthesis.
Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19075240
Leukotrienes are potent adjuvant during fungal infection: effects on memory T cells.
Medeiros AI, Sá-Nunes A, Turato WM, Secatto A, Frantz FG, Sorgi CA, Serezani CH, Deepe GS, Faccioli LH
J Immunol. 2008
PubMed ID: 19050273
The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells.
Willey MB, Alborn WE, Lutzke BS, Lelacheur RM, White RJ, Stavrakis G, Konrad RJ, Ackermann BL
J Pharm Biomed Anal. 2008
PubMed ID: 18996667
Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity.
Leifert WR, Abeywardena MY
Nutr Res. 2008
PubMed ID: 19083497
Increased 5-lipoxygenase immunoreactivity in the hippocampus of patients with Alzheimer's disease.
Ikonomovic MD, Abrahamson EE, Uz T, Manev H, Dekosky ST
J Histochem Cytochem. 2008
PubMed ID: 18678882
Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.
López-Parra M, Titos E, Horrillo R, Ferré N, González-Périz A, Martínez-Clemente M, Planagumà A, Masferrer J, Arroyo V, Clària J
J Lipid Res. 2008
PubMed ID: 18645210
The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis.
Venerito M, Kuester D, Wex T, Roessner A, Malfertheiner P, Treiber G
Cancer Lett. 2008
PubMed ID: 18571838
Correlative study of microvessel density and 5-lipoxygenase expression in human sporadic colorectal cancer.
Barresi V, Vitarelli E, Tuccari G, Barresi G
Arch Pathol Lab Med. 2008
PubMed ID: 18976020
Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.
Melstrom LG, Bentrem DJ, Salabat MR, Kennedy TJ, Ding XZ, Strouch M, Rao SM, Witt RC, Ternent CA, Talamonti MS, Bell RH, Adrian TA
Clin Cancer Res. 2008
PubMed ID: 18927292
5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer.
Wang J, John EM, Ingles SA
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18843019
Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction.
Allayee H, Baylin A, Hartiala J, Wijesuriya H, Mehrabian M, Lusis AJ, Campos H
Am J Clin Nutr. 2008
PubMed ID: 18842779
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Phosphorylation of 5-lipoxygenase at ser523 by protein kinase A determines whether pioglitazone and atorvastatin induce proinflammatory leukotriene B4 or anti-inflammatory 15-epi-lipoxin a4 production.
Ye Y, Lin Y, Perez-Polo JR, Uretsky BF, Ye Z, Tieu BC, Birnbaum Y
J Immunol. 2008
PubMed ID: 18714024
ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.
Telleria JJ, Blanco-Quiros A, Varillas D, Armentia A, Fernandez-Carvajal I, Jesus Alonso M, Diez I
Respir Med. 2008
PubMed ID: 18339529
Caffeic acid attenuates the decrease of cortical BDNF transcript IV mRNA induced by swim stress in wild-type but not in 5-lipoxygenase-deficient mice.
Dzitoyeva S, Imbesi M, Uz T, Dimitrijevic N, Manev H, Manev R
J Neural Transm. 2008
PubMed ID: 18305891
Effects of MK-886, a 5-lipoxygenase activating protein (FLAP) inhibitor, and 5-lipoxygenase deficiency on the forced swimming behavior of mice.
Uz T, Dimitrijevic N, Imbesi M, Manev H, Manev R
Neurosci Lett. 2008
PubMed ID: 18403121
Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.
Assimes TL, Knowles JW, Priest JR, Basu A, Volcik KA, Southwick A, Tabor HK, Hartiala J, Allayee H, Grove ML, Tabibiazar R, Sidney S, Fortmann SP, Go A, Hlatky M, Iribarren C, Boerwinkle E, Myers R, Risch N, Quertermous T
Hum Genet. 2008
PubMed ID: 18369664
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy.
Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS
Diabetes. 2008
PubMed ID: 18346986
Association studies of ALOX5 and bone mineral density in healthy adults.
Foroud T, Ichikawa S, Koller D, Lai D, Curry L, Xuei X, Edenberg HJ, Hui S, Peacock M, Econs MJ
Osteoporos Int. 2008
PubMed ID: 17909879
A rat air pouch model for evaluating the efficacy and selectivity of 5-lipoxygenase inhibitors.
Zweifel BS, Hardy MM, Anderson GD, Dufield DR, Pufahl RA, Masferrer JL
Eur J Pharmacol. 2008
PubMed ID: 18295198
The Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene promoter is not associated with late onset Alzheimer disease.
Alvarez V, González P, Corao AI, Menéndez M, Lahoz CH, Martínez C, Calatayud M, Morales B, Coto E
Alzheimer Dis Assoc Disord. 2008
PubMed ID: 18525291
Lipoxygenase pathway receptor expression in ovarian cancer.
Rocconi RP, Kirby TO, Seitz RS, Beck R, Straughn JM, Alvarez RD, Huh WK
Reprod Sci. 2008
PubMed ID: 18421027
Candidate genes of the 5-lipoxygenase pathway in acute coronary syndrome: a pilot study.
Wung SF, Aouizerat BE
Biol Res Nurs. 2008
PubMed ID: 18398223
The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes.
Albert D, Pergola C, Koeberle A, Dodt G, Steinhilber D, Werz O
J Leukoc Biol. 2008
PubMed ID: 18218859
ALOX5 variants associated with susceptibility to human pulmonary tuberculosis.
Herb F, Thye T, Niemann S, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Werz O, Rüsch-Gerdes S, Horstmann RD, Meyer CG
Hum Mol Genet. 2008
PubMed ID: 18174194
5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease.
Firuzi O, Zhuo J, Chinnici CM, Wisniewski T, Praticò D
FASEB J. 2008
PubMed ID: 17998412
Variations in DNA elucidate molecular networks that cause disease.
Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE
Nature. 2008
PubMed ID: 18344982
Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma.
Möbius C, Aust G, Wiedmann M, Wittekind C, Mössner J, Hauss J, Witzigmann H
Anticancer Res. 2008
PubMed ID: 18507031
Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury.
Jiang W, Hall SR, Moos MP, Cao RY, Ishii S, Ogunyankin KO, Melo LG, Funk CD
Am J Pathol. 2008
PubMed ID: 18276782
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors.
Sud'ina GF, Pushkareva MA, Shephard P, Klein T
Prostaglandins Leukot Essent Fatty Acids. 2008
PubMed ID: 18280718
A novel polymorphism, E254K, in the 5-lipoxygenase gene associated with bronchial asthma.
Bai C, Matsui E, Ohnishi H, Kimata K, Kasahara K, Kaneko H, Kato Z, Fukao T, Kondo N
Int J Mol Med. 2008
PubMed ID: 18204779
5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10-/- mice.
Narushima S, DiMeo D, Tian J, Zhang J, Liu D, Berg DJ
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18048478
Increased interleukin-10 production and Th2 skewing in the absence of 5-lipoxygenase.
DiMeo D, Tian J, Zhang J, Narushima S, Berg DJ
Immunology. 2008
PubMed ID: 17894798
Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells.
Qiu H, Strååt K, Rahbar A, Wan M, Söderberg-Nauclér C, Haeggström JZ
J Exp Med. 2008
PubMed ID: 18180307
Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: A case-control study.
Maznyczka A, Braund P, Mangino M, Samani NJ
Atherosclerosis. 2008
PubMed ID: 18179798
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
Küry S, Buecher B, Robiou-du-Pont S, Scoul C, Colman H, Le Neel T, Le Houérou C, Faroux R, Ollivry J, Lafraise B, Chupin LD, Sébille V, Bézieau S
BMC Cancer. 2008
PubMed ID: 18992148
Pro-inflammatory gene variants in myocardial infarction and longevity: implications for pharmacogenomics.
Listì F, Caruso M, Incalcaterra E, Hoffmann E, Caimi G, Balistreri CR, Vasto S, Scafidi V, Caruso C, Candore G
Curr Pharm Des. 2008
PubMed ID: 18991687
Influence of leukotriene gene polymorphisms on chronic rhinosinusitis.
Al-Shemari H, Bossé Y, Hudson TJ, Cabaluna M, Duval M, Lemire M, Vallee-Smedja S, Frenkiel S, Desrosiers M
BMC Med Genet. 2008
PubMed ID: 18366797
Involvement of LTB4 in zymosan-induced joint nociception in mice: participation of neutrophils and PGE2.
Guerrero AT, Verri WA, Cunha TM, Silva TA, Schivo IR, Dal-Secco D, Canetti C, Rocha FA, Parada CA, Cunha FQ, Ferreira SH
J Leukoc Biol. 2008
PubMed ID: 17913976
Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function.
Vannella KM, McMillan TR, Charbeneau RP, Wilke CA, Thomas PE, Toews GB, Peters-Golden M, Moore BB
J Immunol. 2007
PubMed ID: 18025235
IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production.
Verri WA, Cunha TM, Ferreira SH, Wei X, Leung BP, Fraser A, McInnes IB, Liew FY, Cunha FQ
Eur J Immunol. 2007
PubMed ID: 17979156
NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.
Coffey MJ, Serezani CH, Phare SM, Flamand N, Peters-Golden M
J Leukoc Biol. 2007
PubMed ID: 17761955
Class A scavenger receptor-mediated macrophage adhesion requires coupling of calcium-independent phospholipase A(2) and 12/15-lipoxygenase to Rac and Cdc42 activation.
Nikolic DM, Gong MC, Turk J, Post SR
J Biol Chem. 2007
PubMed ID: 17873277
FcepsilonRI- and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase- and cyclooxygenase-dependent and NADPH oxidase-independent.
Swindle EJ, Coleman JW, DeLeo FR, Metcalfe DD
J Immunol. 2007
PubMed ID: 17982097
Expanding expression of the 5-lipoxygenase/leukotriene B4 pathway in atherosclerotic lesions of diabetic patients promotes plaque instability.
Zhou YJ, Wang JH, Li L, Yang HW, Wen de L, He QC
Biochem Biophys Res Commun. 2007
PubMed ID: 17825794
The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes.
Schnur N, Seuter S, Katryniok C, Rådmark O, Steinhilber D
Biochim Biophys Acta. 2007
PubMed ID: 17894944
Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma.
Faronato M, Muzzonigro G, Milanese G, Menna C, Bonfigli AR, Catalano A, Procopio A
Histol Histopathol. 2007
PubMed ID: 17616938
Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice.
Adamek A, Jung S, Dienesch C, Laser M, Ertl G, Bauersachs J, Frantz S
Eur J Pharmacol. 2007
PubMed ID: 17586489
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
Involvement of 5-lipoxygenase in survival of Epstein-Barr virus (EBV)-converted B lymphoma cells.
Belfiore MC, Natoni A, Barzellotti R, Merendino N, Pessina G, Ghibelli L, Gualandi G
Cancer Lett. 2007
PubMed ID: 17467166
Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J
Am J Med Genet B Neuropsychiatr Genet. 2007
PubMed ID: 17373700
CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients.
Kim SH, Ye YM, Hur GY, Lee SK, Sampson AP, Lee HY, Park HS
Pharmacogenomics. 2007
PubMed ID: 17924829
Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study.
Shen CD, Zhang WL, Sun K, Wang YB, Zhen YS, Hui RT
Ann Hum Genet. 2007
PubMed ID: 17521309
Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice.
Cao RY, Adams MA, Habenicht AJ, Funk CD
Prostaglandins Other Lipid Mediat. 2007
PubMed ID: 17643886
Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene.
Seuter S, Väisänen S, Rådmark O, Carlberg C, Steinhilber D
Biochim Biophys Acta. 2007
PubMed ID: 17500032
Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines.
Zhou GX, Ding XL, Huang JF, Zhang H, Wu SB
Biochim Biophys Acta. 2007
PubMed ID: 17434678
Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin.
Doepping S, Funk CD, Habenicht AJ, Spanbroek R
J Invest Dermatol. 2007
PubMed ID: 17392829
Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4.
Jame AJ, Lackie PM, Cazaly AM, Sayers I, Penrose JF, Holgate ST, Sampson AP
Clin Exp Allergy. 2007
PubMed ID: 17517102
Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock.
Wielockx B, Staelens J, Puimège L, Vanlaere I, Van Roy M, van Lint P, Van Roy F, Libert C
J Immunol. 2007
PubMed ID: 17404289
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease.
Berger W, De Chandt MT, Cairns CB
Int J Clin Pract. 2007
PubMed ID: 17394438
A functional Sp1/Egr1-tandem repeat polymorphism in the 5-lipoxygenase gene is not associated with myocardial infarction.
González P, Reguero JR, Lozano I, Morís C, Coto E
Int J Immunogenet. 2007
PubMed ID: 17373938
Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.
Klotsman M, York TP, Pillai SG, Vargas-Irwin C, Sharma SS, van den Oord EJ, Anderson WH
Pharmacogenet Genomics. 2007
PubMed ID: 17460547
Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma.
Gong Z, Hebert JR, Bostick RM, Deng Z, Hurley TG, Dixon DA, Nitcheva D, Xie D
Cancer. 2007
PubMed ID: 17236225
TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects.
Carlson CS, Heagerty PJ, Nord AS, Pritchard DK, Ranchalis J, Boguch JM, Duan H, Hatsukami TS, Schwartz SM, Rieder MJ, Nickerson DA, Jarvik GP
Hum Genet. 2007
PubMed ID: 17115186
Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice?
Funk CD, Cao RY, Zhao L, Habenicht AJ
Ann N Y Acad Sci. 2006
PubMed ID: 17182931
Platelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase.
Berg C, Hammarström S, Herbertsson H, Lindström E, Svensson AC, Söderström M, Tengvall P, Bengtsson T
Thromb Haemost. 2006
PubMed ID: 17080223
Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase.
Butovich IA, Lukyanova SM, Bachmann C
J Lipid Res. 2006
PubMed ID: 16899822
Expression of 5-lipoxygenase in human colorectal cancer.
Soumaoro LT, Iida S, Uetake H, Ishiguro M, Takagi Y, Higuchi T, Yasuno M, Enomoto M, Sugihara K
World J Gastroenterol. 2006
PubMed ID: 17072961
The coding sequence mediates induction of 5-lipoxygenase expression by Smads3/4.
Seuter S, Sorg BL, Steinhilber D
Biochem Biophys Res Commun. 2006
PubMed ID: 16919603
Distinct effects of annexin A7 and p53 on arachidonate lipoxygenation in prostate cancer cells involve 5-lipoxygenase transcription.
Torosyan Y, Dobi A, Naga S, Mezhevaya K, Glasman M, Norris C, Jiang G, Mueller G, Pollard H, Srivastava M
Cancer Res. 2006
PubMed ID: 17018618
Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats.
Manjunatha H, Srinivasan K
FEBS J. 2006
PubMed ID: 16956363
Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility.
Serezani CH, Perrela JH, Russo M, Peters-Golden M, Jancar S
J Immunol. 2006
PubMed ID: 16920959
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.
Rakonjac M, Fischer L, Provost P, Werz O, Steinhilber D, Samuelsson B, Rådmark O
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16924104
Role of 5-lipoxygenase in IL-13-induced pulmonary inflammation and remodeling.
Shim YM, Zhu Z, Zheng T, Lee CG, Homer RJ, Ma B, Elias JA
J Immunol. 2006
PubMed ID: 16849505
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site.
Sorg BL, Klan N, Seuter S, Dishart D, Rådmark O, Habenicht A, Carlberg C, Werz O, Steinhilber D
Biochim Biophys Acta. 2006
PubMed ID: 16750418
Increased expression of lipoxygenase enzymes during pollen season in nasal biopsies of pollen-allergic patients.
Plewako H, Holmberg K, Oancea I, Rak S
Allergy. 2006
PubMed ID: 16677242
Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice.
Ghazalpour A, Wang X, Lusis AJ, Mehrabian M
Genetics. 2006
PubMed ID: 16624897
Differential regulation by leukotrienes and calcium of Fc gamma receptor-induced phagocytosis and Syk activation in dendritic cells versus macrophages.
Canetti C, Aronoff DM, Choe M, Flamand N, Wettlaufer S, Toews GB, Chen GH, Peters-Golden M
J Leukoc Biol. 2006
PubMed ID: 16574771
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.
Qiu H, Gabrielsen A, Agardh HE, Wan M, Wetterholm A, Wong CH, Hedin U, Swedenborg J, Hansson GK, Samuelsson B, Paulsson-Berne G, Haeggström JZ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16698924
Activation of 5-lipoxygenase after oxygen-glucose deprivation is partly mediated via NMDA receptor in rat cortical neurons.
Ge QF, Wei EQ, Zhang WP, Hu X, Huang XJ, Zhang L, Song Y, Ma ZQ, Chen Z, Luo JH
J Neurochem. 2006
PubMed ID: 16606359
Inhibitory effects of mizolastine on ultraviolet B-induced leukotriene B4 production and 5-lipoxygenase expression in normal human dermal fibroblasts in vitro.
Yan Y, Wang B, Zuo YG, Qu T
Photochem Photobiol. 2006
PubMed ID: 16402861
Arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits.
Lyons MA
Circ Res. 2006
PubMed ID: 16645143
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells.
Chen JH, Bian XW, Yao XH, Gong W, Hu J, Chen K, Iribarren P, Zhao W, Zhou XD
Biochem Biophys Res Commun. 2006
PubMed ID: 16516855
Neutrophil-derived leukotriene B4 is required for inflammatory arthritis.
Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, Lee DM
J Exp Med. 2006
PubMed ID: 16567388
Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine.
Zarini S, Gijón MA, Folco G, Murphy RC
J Biol Chem. 2006
PubMed ID: 16495221
Binding investigation of human 5-lipoxygenase with its inhibitors by SPR technology correlating with molecular docking simulation.
Du L, Zhang Z, Luo X, Chen K, Shen X, Jiang H
J Biochem. 2006
PubMed ID: 16672272
Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis.
Liao T, Ke Y, Shao WH, Haribabu B, Kaplan HJ, Sun D, Shao H
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 16565390
N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity.
Taccone-Gallucci M, Manca-di-Villahermosa S, Battistini L, Stuffler RG, Tedesco M, Maccarrone M
Kidney Int. 2006
PubMed ID: 16531984
Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps.
Poole EM, Bigler J, Whitton J, Sibert JG, Potter JD, Ulrich CM
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16537708
Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C
Nat Immunol. 2006
PubMed ID: 16444258
Influence of leukotriene pathway polymorphisms on response to montelukast in asthma.
Lima JJ, Zhang S, Grant A, Shao L, Tantisira KG, Allayee H, Wang J, Sylvester J, Holbrook J, Wise R, Weiss ST, Barnes K
Am J Respir Crit Care Med. 2006
PubMed ID: 16293801
Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.
Flamand N, Lefebvre J, Surette ME, Picard S, Borgeat P
J Biol Chem. 2006
PubMed ID: 16275640
Pharmacological inhibition of leukotrienes in an animal model of bleomycin-induced acute lung injury.
Failla M, Genovese T, Mazzon E, Gili E, Muià C, Sortino M, Crimi N, Caputi AP, Cuzzocrea S, Vancheri C
Respir Res. 2006
PubMed ID: 17118201
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
Am J Hum Genet. 2006
PubMed ID: 16385451
ALOX5 promoter genotype, asthma severity and LTC production by eosinophils.
Kalayci O, Birben E, Sackesen C, Keskin O, Tahan F, Wechsler ME, Civelek E, Soyer OU, Adalioglu G, Tuncer A, Israel E, Lilly C
Allergy. 2006
PubMed ID: 16364163
Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats.
Lefebvre B, Caron F, Bessard G, Stanke-Labesque F
J Hypertens. 2006
PubMed ID: 16331105
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.
Dishart D, Schnur N, Klan N, Werz O, Steinhilber D, Samuelsson B, Rådmark O
Biochim Biophys Acta. 2005
PubMed ID: 16413224
Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent.
Peebles RS, Hashimoto K, Sheller JR, Moore ML, Morrow JD, Ji S, Elias JA, Goleniewska K, O'neal J, Mitchell DB, Graham BS, Zhou W
J Immunol. 2005
PubMed ID: 16339565
Stress-induced nuclear export of 5-lipoxygenase.
Hanaka H, Shimizu T, Izumi T
Biochem Biophys Res Commun. 2005
PubMed ID: 16165096
Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population.
Kim SH, Choi JH, Holloway JW, Suh CH, Nahm DH, Ha EH, Park CS, Park HS
J Korean Med Sci. 2005
PubMed ID: 16361798
Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits.
Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE
Nat Genet. 2005
PubMed ID: 16200066
Expression of 5-lipoxygenase in specialized epithelial cells of nasopharyngeal-associated lymphoid tissue.
Brock TG
J Mol Histol. 2005
PubMed ID: 16733792
Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}.
Rossi A, Acquaviva AM, Iuliano F, Di Paola R, Cuzzocrea S, Sautebin L
J Leukoc Biol. 2005
PubMed ID: 16046553
Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils.
Serezani CH, Aronoff DM, Jancar S, Peters-Golden M
J Leukoc Biol. 2005
PubMed ID: 16006535
Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis.
Machado ER, Ueta MT, Lourenço EV, Anibal FF, Sorgi CA, Soares EG, Roque-Barreira MC, Medeiros AI, Faccioli LH
J Immunol. 2005
PubMed ID: 16148135
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.
Werz O, Tretiakova I, Michel A, Ulke-Lemee A, Hörnig M, Franke L, Schneider G, Samuelsson B, Rådmark O, Steinhilber D
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16135563
The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis.
Lötzer K, Funk CD, Habenicht AJ
Biochim Biophys Acta. 2005
PubMed ID: 16081317
Antisense transcription in the mammalian transcriptome.
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Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
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Science. 2005
PubMed ID: 16141072
Involvement of 5-lipoxygenase in spinal cord injury.
Genovese T, Mazzon E, Rossi A, Di Paola R, Cannavò G, Muià C, Crisafulli C, Bramanti P, Sautebin L, Cuzzocrea S
J Neuroimmunol. 2005
PubMed ID: 16019083
Association between 5-lipoxygenase expression and plaque instability in humans.
Cipollone F, Mezzetti A, Fazia ML, Cuccurullo C, Iezzi A, Ucchino S, Spigonardo F, Bucci M, Cuccurullo F, Prescott SM, Stafforini DM
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15933245
5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury.
Caironi P, Ichinose F, Liu R, Jones RC, Bloch KD, Zapol WM
Am J Respir Crit Care Med. 2005
PubMed ID: 15894604
Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase.
Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M
Blood. 2005
PubMed ID: 15718414
1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain.
Hörnig C, Albert D, Fischer L, Hörnig M, Rådmark O, Steinhilber D, Werz O
J Biol Chem. 2005
PubMed ID: 15923196
5-Lipoxygenase, a marker for early pancreatic intraepithelial neoplastic lesions.
Hennig R, Grippo P, Ding XZ, Rao SM, Buchler MW, Friess H, Talamonti MS, Bell RH, Adrian TE
Cancer Res. 2005
PubMed ID: 16024599
Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production.
Bafica A, Scanga CA, Serhan C, Machado F, White S, Sher A, Aliberti J
J Clin Invest. 2005
PubMed ID: 15931391
5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration.
Cuzzocrea S, Rossi A, Mazzon E, Di Paola R, Genovese T, Muià C, Caputi AP, Sautebin L
Lab Invest. 2005
PubMed ID: 15821759
Mutation analysis of the human 5-lipoxygenase C-terminus: support for a stabilizing C-terminal loop.
Okamoto H, Hammarberg T, Zhang YY, Persson B, Watanabe T, Samuelsson B, Rådmark O
Biochim Biophys Acta. 2005
PubMed ID: 15848143
Increased 5-lipoxygenase expression and induction of apoptosis by its inhibitors in esophageal cancer: a potential target for prevention.
Hoque A, Lippman SM, Wu TT, Xu Y, Liang ZD, Swisher S, Zhang H, Cao L, Ajani JA, Xu XC
Carcinogenesis. 2005
PubMed ID: 15661803
Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition.
Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC
Pediatr Nephrol. 2005
PubMed ID: 15549416
Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis.
Benjamim CF, Canetti C, Cunha FQ, Kunkel SL, Peters-Golden M
J Immunol. 2005
PubMed ID: 15661924
5-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation.
Catalano A, Rodilossi S, Caprari P, Coppola V, Procopio A
EMBO J. 2005
PubMed ID: 15616590
5-lipoxygenase expression and activity in aorta from streptozotocin-induced diabetic rats.
Hardy G, Vergnaud S, Lunardi J, Peoc'h M, Bessard G, Stanke-Labesque F
Prostaglandins Other Lipid Mediat. 2005
PubMed ID: 15789618
AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities.
Ménard C, Valastro B, Martel MA, Chartier E, Marineau A, Baudry M, Massicotte G
Hippocampus. 2005
PubMed ID: 15630695
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, Lavigne M, Pelletier JP
Arthritis Rheum. 2004
PubMed ID: 15593193
Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
Goodman JE, Bowman ED, Chanock SJ, Alberg AJ, Harris CC
Carcinogenesis. 2004
PubMed ID: 15308583
Multiple nuclear localization sequences allow modulation of 5-lipoxygenase nuclear import.
Luo M, Pang CW, Gerken AE, Brock TG
Traffic. 2004
PubMed ID: 15479450
Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.
Collin M, Rossi A, Cuzzocrea S, Patel NS, Di Paola R, Hadley J, Collino M, Sautebin L, Thiemermann C
J Leukoc Biol. 2004
PubMed ID: 15328337
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Induction of inducible nitric oxide synthase by lipopolysaccharide/interferon gamma and sepsis down-regulates 5-lipoxygenase metabolism in murine alveolar macrophages.
Coffey M, Phare S, Peters-Golden M
Exp Lung Res. 2004
PubMed ID: 15371096
Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523.
Luo M, Jones SM, Phare SM, Coffey MJ, Peters-Golden M, Brock TG
J Biol Chem. 2004
PubMed ID: 15280375
Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase.
Emerson MR, LeVine SM
Brain Res. 2004
PubMed ID: 15328042
5-lipoxygenase and cyclooxygenase regulate wound closure in NIH/3T3 fibroblast monolayers.
Green JA, Stockton RA, Johnson C, Jacobson BS
Am J Physiol Cell Physiol. 2004
PubMed ID: 15197007
Lipoxygenase-dependent superoxide release in skeletal muscle.
Zuo L, Christofi FL, Wright VP, Bao S, Clanton TL
J Appl Physiol. 2004
PubMed ID: 15107407
Characterization of calcium and magnesium binding domains of human 5-lipoxygenase.
Bindu PH, Sastry GM, Sastry GN
Biochem Biophys Res Commun. 2004
PubMed ID: 15219851
E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, Morham SG, Langenbach R, Stock JL, McNeish JD, Smithies O, Coffman TM, Koller BH
J Immunol. 2004
PubMed ID: 15240726
The expression of cyclooxygenase-1, cyclooxygenase-2 and 5-lipoxygenase in inflammatory muscle tissue of patients with polymyositis and dermatomyositis.
Studýnková JT, Kuchen S, Jeisy E, Schedel J, Charvát F, Jarosová K, Sprott H, Matucci-Cerinic M, Gay RE, Michel BA, Pavelka K, Vencovský J, Gay S
Clin Exp Rheumatol. 2004
PubMed ID: 15301234
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
Nature. 2004
PubMed ID: 15164054
Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats.
Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang YY
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 14726295
Cerebral ischemia in 5-lipoxygenase knockout mice.
Kitagawa K, Matsumoto M, Hori M
Brain Res. 2004
PubMed ID: 15033436
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Matsuyama M, Yoshimura R, Mitsuhashi M, Hase T, Tsuchida K, Takemoto Y, Kawahito Y, Sano H, Nakatani T
Int J Oncol. 2004
PubMed ID: 15010818
Relationship between lipoxygenase and human testicular cancer.
Yoshimura R, Matsuyama M, Mitsuhashi M, Takemoto Y, Tsuchida K, Kawahito Y, Sano H, Nakatani T
Int J Mol Med. 2004
PubMed ID: 14767568
Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase.
Choi JH, Park HS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD
Hum Genet. 2004
PubMed ID: 14749922
Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis.
Dwyer JH, Allayee H, Dwyer KM, Fan J, Wu H, Mar R, Lusis AJ, Mehrabian M
N Engl J Med. 2004
PubMed ID: 14702425
Metabolic changes of arachidonic acid after cerebral ischemia-reperfusion in diabetic rats.
Zhang RL, Lu CZ, Ren HM, Xiao BG
Exp Neurol. 2003
PubMed ID: 14769366
Arachidonic acid cascade inhibitors modulate phorbol ester-induced oxidative stress in female ICR mouse skin: differential roles of 5-lipoxygenase and cyclooxygenase-2 in leukocyte infiltration and activation.
Nakamura Y, Kozuka M, Naniwa K, Takabayashi S, Torikai K, Hayashi R, Sato T, Ohigashi H, Osawa T
Free Radic Biol Med. 2003
PubMed ID: 14572603
Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors.
Yoshimura R, Matsuyama M, Tsuchida K, Kawahito Y, Sano H, Nakatani T
J Urol. 2003
PubMed ID: 14532840
The C2-like beta-barrel domain mediates the Ca2+-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1.
Bürkert E, Arnold C, Hammarberg T, Rådmark O, Steinhilber D, Werz O
J Biol Chem. 2003
PubMed ID: 12893830
Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity.
Luo M, Jones SM, Peters-Golden M, Brock TG
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14530386
Levels of expression of lipoxygenases and cyclooxygenase-2 in human breast cancer.
Jiang WG, Douglas-Jones A, Mansel RE
Prostaglandins Leukot Essent Fatty Acids. 2003
PubMed ID: 12907138
5-lipoxygenase knockout mice exhibit a resistance to acute pancreatitis induced by cerulein.
Cuzzocrea S, Rossi A, Serraino I, Di Paola R, Dugo L, Genovese T, Britti D, Sciarra G, De Sarro A, Caputi AP, Sautebin L
Immunology. 2003
PubMed ID: 12941149
5-lipoxygenase knockout mice exhibit a resistance to splanchnic artery occlusion shock.
Cuzzocrea S, Rossi A, Serraino I, Di Paola R, Dugo L, Genovese T, Caputi AP, Sautebin L
Shock. 2003
PubMed ID: 12923494
5-Lipoxygenase is involved in the angiotensin II-induced NAD(P)H-oxidase activation.
Luchtefeld M, Drexler H, Schieffer B
Biochem Biophys Res Commun. 2003
PubMed ID: 12914802
Promoter polymorphism in the 5-lipoxygenase (ALOX5) and 5-lipoxygenase-activating protein (ALOX5AP) genes and asthma susceptibility in a Caucasian population.
Sayers I, Barton S, Rorke S, Sawyer J, Peng Q, Beghé B, Ye S, Keith T, Clough JB, Holloway JW, Sampson AP, Holgate ST
Clin Exp Allergy. 2003
PubMed ID: 12911785
Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase.
Ghosh J
Biochem Biophys Res Commun. 2003
PubMed ID: 12859962
Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression.
Wang XJ, Dyson MT, Jo Y, Eubank DW, Stocco DM
J Steroid Biochem Mol Biol. 2003
PubMed ID: 12943700
5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan.
Cuzzocrea S, Rossi A, Serraino I, Mazzon E, Di Paola R, Dugo L, Genovese T, Calabrò B, Caputi AP, Sautebin L
J Leukoc Biol. 2003
PubMed ID: 12773506
Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog.
Kuhn H, Anton M, Gerth C, Habenicht A
Arterioscler Thromb Vasc Biol. 2003
PubMed ID: 12730086
Platelets abrogate leukotriene B(4) generation by human blood neutrophils stimulated with monosodium urate monohydrate or f-Met-Leu-Phe in vitro.
Chabannes B, Poubelle PE, Molière P, De Médicis R, Lussier A, Lagarde M
Lab Invest. 2003
PubMed ID: 12695552
Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.
Klegeris A, McGeer PL
J Leukoc Biol. 2003
PubMed ID: 12629151
Increased expression of 5-lipoxygenase in glioblastoma multiforme.
Golubic M, Prayson RA, Vargo L, Bondar J, Barnett GH
Adv Exp Med Biol. 2003
PubMed ID: 12751769
The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.
Nielsen CK, Ohd JF, Wikström K, Massoumi R, Paruchuri S, Juhas M, Sjölander A
Adv Exp Med Biol. 2003
PubMed ID: 12751768
LTC4 production by eosinophils in asthmatic subjects with alternative forms of ALOX-5 core promoter.
Kalayci O, Wechsler M, Galper B, Hong C, Israel E, Drazen JM, Lilly CM
Adv Exp Med Biol. 2003
PubMed ID: 12751728
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.
Bürkert E, Szellas D, Rådmark O, Steinhilber D, Werz O
J Leukoc Biol. 2003
PubMed ID: 12525578
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs.
Hosford GE, Koyanagi KS, Leung WI, Olson DM
Exp Lung Res. 2002
PubMed ID: 12490039
Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein.
Jones SM, Luo M, Healy AM, Peters-Golden M, Brock TG
J Biol Chem. 2002
PubMed ID: 12140292
Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism.
Coffey MJ, Phare SM, Peters-Golden M
Biochim Biophys Acta. 2002
PubMed ID: 12385890
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.
Tong WG, Ding XZ, Witt RC, Adrian TE
Mol Cancer Ther. 2002
PubMed ID: 12481414
Cholesterol-dependent modulation of the toxicity of HIV-1 coat protein gp120 in human neuroblastoma cells.
Maccarrone M, Navarra M, Catani V, Corasaniti MT, Bagetta G, Finazzi-Agrò A
J Neurochem. 2002
PubMed ID: 12354292
Expression of 5-lipoxygenase mRNA is unchanged in the colon of patients with active inflammatory bowel disease.
Hendel J, Ahnfelt-Rønne I, Nielsen OH
Inflamm Res. 2002
PubMed ID: 12234060
5-Lipoxygenase and leukotriene B(4) receptor are expressed in human pancreatic cancers but not in pancreatic ducts in normal tissue.
Hennig R, Ding XZ, Tong WG, Schneider MB, Standop J, Friess H, Büchler MW, Pour PM, Adrian TE
Am J Pathol. 2002
PubMed ID: 12163367
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice.
Mehrabian M, Allayee H, Wong J, Shi W, Wang XP, Shaposhnik Z, Funk CD, Lusis AJ, Shih W
Circ Res. 2002
PubMed ID: 12142344
5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists.
Fowler SJ, Hall IP, Wilson AM, Wheatley AP, Lipworth BJ
Eur J Clin Pharmacol. 2002
PubMed ID: 12107604
Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo.
Fabre JE, Goulet JL, Riche E, Nguyen M, Coggins K, Offenbacher S, Koller BH
J Clin Invest. 2002
PubMed ID: 12021253
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).
Werz O, Szellas D, Steinhilber D, Rådmark O
J Biol Chem. 2002
PubMed ID: 11844797
Molecular basis of the specific subcellular localization of the C2-like domain of 5-lipoxygenase.
Kulkarni S, Das S, Funk CD, Murray D, Cho W
J Biol Chem. 2002
PubMed ID: 11796736
Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme.
Hemak J, Gale D, Brock TG
J Mol Model. 2002
PubMed ID: 12111389
Cloning and functional analysis of the mouse 5-lipoxygenase promoter.
Silverman ES, Le L, Baron RM, Hallock A, Hjoberg J, Shikanai T, Storm van's Gravesande K, Auron PE, Lu W
Am J Respir Cell Mol Biol. 2002
PubMed ID: 11919084
Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation.
Segal BH, Kuhns DB, Ding L, Gallin JI, Holland SM
J Leukoc Biol. 2002
PubMed ID: 11867678
Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects.
Seymour ML, Gilby N, Bardin PG, Fraenkel DJ, Sanderson G, Penrose JF, Holgate ST, Johnston SL, Sampson AP
J Infect Dis. 2002
PubMed ID: 11865407
5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes.
Graupera M, García-Pagán JC, Titos E, Claria J, Massaguer A, Bosch J, Rodés J
Gastroenterology. 2002
PubMed ID: 11832453
Protection from pulmonary fibrosis in leukotriene-deficient mice.
Peters-Golden M, Bailie M, Marshall T, Wilke C, Phan SH, Toews GB, Moore BB
Am J Respir Crit Care Med. 2002
PubMed ID: 11790660
Calcium binding to 5-lipoxygenase.
Hammarberg T, Reddy KV, Persson B, Rådmark O
Adv Exp Med Biol. 2002
PubMed ID: 12664574
Down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to lipopolysaccharide.
Brock TG
Adv Exp Med Biol. 2002
PubMed ID: 12664571
5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior.
Uz T, Dimitrijevic N, Tueting P, Manev H
Restor Neurol Neurosci. 2002
PubMed ID: 12237493
Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice.
Goulet JL, Griffiths RC, Ruiz P, Mannon RB, Flannery P, Platt JL, Koller BH, Coffman TM
J Immunol. 2001
PubMed ID: 11714834
Predictive genetic testing -- new possibilities in determination of risk of complex diseases.
Quinzii C, Belpinati F, Pignatti PF
Croat Med J. 2001
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Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization.
Escoubet-Lozach L, M'Rini C, Rey A, Béraud M, Lepert JC, Courtade M, Frisach MF, Pipy B
Clin Exp Allergy. 2001
PubMed ID: 11468001
Neurogenesis and neuroprotection in the adult brain. A putative role for 5-lipoxygenase?
Manev H, Uz T, Manev R, Zhang Z
Ann N Y Acad Sci. 2001
PubMed ID: 11462800
5-Lipoxygenase interacts with coactosin-like protein.
Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O
J Biol Chem. 2001
PubMed ID: 11297527
Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice.
Ichinose F, Zapol WM, Sapirstein A, Ullrich R, Tager AM, Coggins K, Jones R, Bloch KD
Circ Res. 2001
PubMed ID: 11325876
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Structural basis for lipoxygenase specificity. Conversion of the human leukocyte 5-lipoxygenase to a 15-lipoxygenating enzyme species by site-directed mutagenesis.
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J Biol Chem. 2001
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences.
Zhang YY, Hammarberg T, Radmark O, Samuelsson B, Ng CF, Funk CD, Loscalzo J
Biochem J. 2000
PubMed ID: 11042125
In situ amplification of 5-lipoxygenase and 5-lipoxygenase-activating protein in allergic airway inflammation and inhibition by leukotriene blockade.
Chu SJ, Tang LO, Watney E, Chi EY, Henderson WR
J Immunol. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
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Comparative effects of long-acting beta2-agonists, leukotriene receptor antagonists, and a 5-lipoxygenase inhibitor on exercise-induced asthma.
Coreno A, Skowronski M, Kotaru C, McFadden ER
J Allergy Clin Immunol. 2000
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5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases.
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Proc Natl Acad Sci U S A. 2000
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The molecular biology and regulation of 5-lipoxygenase.
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Am J Respir Crit Care Med. 2000
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Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase.
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J Biol Chem. 1999
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Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice.
Goulet JL, Griffiths RC, Ruiz P, Spurney RF, Pisetsky DS, Koller BH, Coffman TM
J Immunol. 1999
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Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment.
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Nat Genet. 1999
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Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade.
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Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics.
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Biochem Biophys Res Commun. 1998
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5-Lipoxygenase expression in Langerhans cells of normal human epidermis.
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5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension.
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Am J Respir Crit Care Med. 1998
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Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
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5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice.
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Contrasting effects of proinflammatory and T-helper lymphocyte subset-2 cytokines on the 5-lipoxygenase pathway in monocytes.
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Inhibition of LTB4 biosynthesis in situ by CGS 23885, a potent 5-lipoxygenase inhibitor, correlates with its pleural fluid concentrations in an experimentally induced rat pleurisy model.
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Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence.
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J Biol Chem. 1997
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A transforming growth factor-beta regulable RNA-binding protein interacts specifically with germline Ig alpha transcripts.
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Int Immunol. 1997
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Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities.
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J Immunol. 1996
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The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice.
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Biochim Biophys Acta. 1996
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The importance of leukotrienes in airway inflammation in a mouse model of asthma.
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Genome Res. 1996
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Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats.
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J Clin Invest. 1996
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Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis.
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J Clin Invest. 1996
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Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2.
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Anal Biochem. 1995
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Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes.
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cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase.
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Nature. 1994
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5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.
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J Biol Chem. 1994
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Cyclooxygenase gene expression in human endometrium and decidua.
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Targeted gene disruption by homologous recombination. Toward an understanding of specific blood cell functions.
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Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids.
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Am J Respir Crit Care Med. 1994
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5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.
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J Exp Med. 1993
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5-Lipoxygenase activity in the human pancreas.
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J Lipid Mediat. 1993
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Crystallographic determination of the active site iron and its ligands in soybean lipoxygenase L-1.
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Biochemistry. 1993
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J Pharmacol Exp Ther. 1992
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Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.
Ishii S, Noguchi M, Miyano M, Matsumoto T, Noma M
Biochem Biophys Res Commun. 1992
PubMed ID: 1540191
Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.
Nguyen T, Falgueyret JP, Abramovitz M, Riendeau D
J Biol Chem. 1991
PubMed ID: 1939225
Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis.
Gross NJ, Holloway NO, Narine KR
Radiat Res. 1991
PubMed ID: 1886988
Characterization of the human 5-lipoxygenase gene promoter.
Hoshiko S, Rådmark O, Samuelsson B
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2251250
Characterization of the human 5-lipoxygenase gene.
Funk CD, Hoshiko S, Matsumoto T, Rdmark O, Samuelsson B
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2565035
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
Matsumoto T, Funk CD, Rådmark O, Höög JO, Jörnvall H, Samuelsson B
Adv Prostaglandin Thromboxane Leukot Res. 1989
PubMed ID: 2526519
Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase.
Balcarek JM, Theisen TW, Cook MN, Varrichio A, Hwang SM, Strohsacker MW, Crooke ST
J Biol Chem. 1988
PubMed ID: 3417684
Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.
Rouzer CA, Kargman S
J Biol Chem. 1988
PubMed ID: 3134355
Cloning of the cDNA for human 5-lipoxygenase.
Dixon RA, Jones RE, Diehl RE, Bennett CD, Kargman S, Rouzer CA
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3422434
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
Matsumoto T, Funk CD, Rådmark O, Höög JO, Jörnvall H, Samuelsson B
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2829172
Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase.
Rouzer CA, Samuelsson B
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3118366

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	240	11689	25290
EnsEMBL Gene(s)	ENSG00000012779	ENSMUSG00000025701	ENSRNOG00000012972
Unigene	Hs.89499	Mm.41072	Rn.9662
Homologene	ALOX5	Alox5	Alox5
OMIM	152390	N/A	N/A
GeneCards	ALOX5	N/A	N/A
Beta Cell Genomics	DT.121243064 DT.449694 DT.92427412	DT.110483153 DT.490623 DT.94294351 DT.97338506 DT.99853905	N/A
Reactome	P09917	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	240	11689	25290

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
ALOX5	COTL1	HPRD, IntAct, BioGRID	empirical	11297527 10051563
ALOX5	ALOX5AP	HPRD	empirical	9445303
ALOX5	COTL1P1	BioGRID	empirical	10051563
ALOX5	GRB2	HPRD, BioGRID	empirical	8585605 7929073
ALOX5	ACTB	HPRD	empirical	7929073
ALOX5	MAPKAPK2	HPRD	empirical	10779545 11844797
ALOX5	TGFBRAP1	HPRD	empirical	10051563