FLOT2
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(Human) GRCh37 - chr17:27206353..27224715 (18.36 kb) View in Genome Browser
(Mouse) NCBIM37 - chr11:77851433..77873936 (22.50 kb) View in Genome Browser
(Rat) RGSC3.4 - chr10:64081463..64104166 (22.70 kb) View in Genome Browser
HaemAtlas Expression Table for FLOT2:
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for FLOT2:The FLOT2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| FLOT2 | FLOT1 | HPRD, MINT | empirical | 17113085 19298817 |
| FLOT2 | CFTR | IntAct | empirical | 17110338 |
| FLOT2 | CBX1 | IntAct, BioGRID | empirical | 20360068 |
| FLOT2 | TRIM69 | IntAct, BioGRID | empirical | 20360068 |
| FLOT2 | DOM3Z | HPRD, MINT, IntAct | empirical | 14667819 |
| FLOT2 | SPATA24 | IntAct | empirical | 21988832 |
| FLOT2 | FYN | HPRD | empirical | 11598189 |
| FLOT2 | GRIN1 | MINT | empirical | 19298817 |
| FLOT2 | GRIN2B | MINT | empirical | 19298817 |
| FLOT2 | APP | IntAct | empirical | 22036569 |
| FLOT2 | IRS1 | IntAct | empirical | 15602769 |
| FLOT2 | MME | IntAct, BioGRID | empirical | 17342744 |
| FLOT2 | ATP6V1A | IntAct | empirical | 21674799 |
| FLOT2 | NMNAT1 | IntAct | empirical | 21988832 |
| FLOT2 | UBC | BioGRID | empirical | 21987572 21139048 21890473 21906983 |
| FLOT2 | YWHAB | IntAct | empirical | 16635246 |
| FLOT2 | CAV1 | HPRD, IntAct, BioGRID | empirical | 10212252 15293782 |
| FLOT2 | CAV2 | HPRD | empirical | 10212252 |
| FLOT2 | CAV3 | MINT | empirical | 16932745 |
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Publications: 77
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Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.
Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21187433
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.
Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Krüger M, Rudel T, Linder S
Mol Biol Cell. 2011
PubMed ID: 21119006
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Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.
Ludwig A, Otto GP, Riento K, Hams E, Fallon PG, Nichols BJ
J Cell Biol. 2010
PubMed ID: 21059848
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Flotillin-mediated endocytic events dictate cell type-specific responses to semaphorin 3A.
Carcea I, Ma'ayan A, Mesias R, Sepulveda B, Salton SR, Benson DL
J Neurosci. 2010
PubMed ID: 21068336
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A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.
Gorbea C, Pratt G, Ustrell V, Bell R, Sahasrabudhe S, Hughes RE, Rechsteiner M
J Biol Chem. 2010
PubMed ID: 20682791
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Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
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Cellular roles of the prion protein in association with reggie/flotillin microdomains.
Solis GP, Malaga-Trillo E, Plattner H, Stuermer CA
Front Biosci. 2010
PubMed ID: 20515742
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Basolateral internalization of GPI-anchored proteins occurs via a clathrin-independent flotillin-dependent pathway in polarized hepatic cells.
Aït-Slimane T, Galmes R, Trugnan G, Maurice M
Mol Biol Cell. 2009
PubMed ID: 19605558
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Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.
Hung YH, Robb EL, Volitakis I, Ho M, Evin G, Li QX, Culvenor JG, Masters CL, Cherny RA, Bush AI
J Biol Chem. 2009
PubMed ID: 19542222
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An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
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Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis.
Babuke T, Ruonala M, Meister M, Amaddii M, Genzler C, Esposito A, Tikkanen R
Cell Signal. 2009
PubMed ID: 19318123
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Reggies/flotillins regulate retinal axon regeneration in the zebrafish optic nerve and differentiation of hippocampal and N2a neurons.
Munderloh C, Solis GP, Bodrikov V, Jaeger FA, Wiechers M, Málaga-Trillo E, Stuermer CA
J Neurosci. 2009
PubMed ID: 19458231
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm.
Miranda PV, Allaire A, Sosnik J, Visconti PE
Biol Reprod. 2009
PubMed ID: 19144954
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NMDA receptors interact with flotillin-1 and -2, lipid raft-associated proteins.
Swanwick CC, Shapiro ME, Yi Z, Chang K, Wenthold RJ
FEBS Lett. 2009
PubMed ID: 19298817
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Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase.
Riento K, Frick M, Schafer I, Nichols BJ
J Cell Sci. 2009
PubMed ID: 19258392
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Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2.
Lalazar G, Ben Ya'acov A, Livovsky DM, El Haj M, Pappo O, Preston S, Zolotarov L, Ilan Y
Am J Pathol. 2009
PubMed ID: 19246642
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Flotillins are involved in the polarization of primitive and mature hematopoietic cells.
Rajendran L, Beckmann J, Magenau A, Boneberg EM, Gaus K, Viola A, Giebel B, Illges H
PLoS One. 2009
PubMed ID: 20027317
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Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod.
Rossy J, Schlicht D, Engelhardt B, Niggli V
PLoS One. 2009
PubMed ID: 19404397
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Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2.
Langhorst MF, Reuter A, Jaeger FA, Wippich FM, Luxenhofer G, Plattner H, Stuermer CA
Eur J Cell Biol. 2008
PubMed ID: 18237819
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Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons.
Schneider A, Rajendran L, Honsho M, Gralle M, Donnert G, Wouters F, Hell SW, Simons M
J Neurosci. 2008
PubMed ID: 18337418
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Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members.
Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
Mol Cancer Res. 2008
PubMed ID: 18296650
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Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin.
Langhorst MF, Solis GP, Hannbeck S, Plattner H, Stuermer CA
FEBS Lett. 2007
PubMed ID: 17854803
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Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein.
Limpert AS, Karlo JC, Landreth GE
Mol Cell Biol. 2007
PubMed ID: 17548467
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Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding.
Frick M, Bright NA, Riento K, Bray A, Merrified C, Nichols BJ
Curr Biol. 2007
PubMed ID: 17600709
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Reggie-1 and reggie-2 localize in non-caveolar rafts in epithelial cells: cellular localization is not dependent on the expression of caveolin proteins.
Fernow I, Icking A, Tikkanen R
Eur J Cell Biol. 2007
PubMed ID: 17482312
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Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells.
Murata T, Lin MI, Stan RV, Bauer PM, Yu J, Sessa WC
J Biol Chem. 2007
PubMed ID: 17416589
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The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase.
Sugawara Y, Nishii H, Takahashi T, Yamauchi J, Mizuno N, Tago K, Itoh H
Cell Signal. 2007
PubMed ID: 17307333
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HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells.
Dall'Era MA, Oudes A, Martin DB, Liu AY
Prostate. 2007
PubMed ID: 17342744
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Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains.
Solis GP, Hoegg M, Munderloh C, Schrock Y, Malaga-Trillo E, Rivera-Milla E, Stuermer CA
Biochem J. 2007
PubMed ID: 17206938
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Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389395
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Arginase-flotillin interaction brings arginase to red blood cell membrane.
Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z
FEBS Lett. 2006
PubMed ID: 17113085
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High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma.
Doherty SD, Prieto VG, George S, Hazarika P, Duvic M
Melanoma Res. 2006
PubMed ID: 17013097
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Caveolins and flotillin-2 are present in the blood stages of Plasmodium vivax.
Bracho C, Dunia I, Romano M, Raposo G, De La Rosa M, Benedetti EL, Pérez HA
Parasitol Res. 2006
PubMed ID: 16521037
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DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
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Preformed reggie/flotillin caps: stable priming platforms for macrodomain assembly in T cells.
Langhorst MF, Reuter A, Luxenhofer G, Boneberg EM, Legler DF, Plattner H, Stuermer CA
FASEB J. 2006
PubMed ID: 16452278
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G
J Biol Chem. 2005
PubMed ID: 15886206
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Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
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D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells.
Yu P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA
Kidney Int. 2004
PubMed ID: 15569306
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Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1.
Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M
Cancer Res. 2004
PubMed ID: 15492257
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
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Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression.
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Biochem J. 2004
PubMed ID: 14599293
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Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
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Genomics. 2004
PubMed ID: 14667819
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.
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Biochem Biophys Res Commun. 2003
PubMed ID: 12927782
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Xanthine oxidoreductase is central to the evolution and function of the innate immune system.
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Trends Immunol. 2003
PubMed ID: 12967676
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Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.
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J Biol Chem. 2003
PubMed ID: 12493773
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
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Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.
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Mol Vis. 2002
PubMed ID: 12107410
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
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Science. 2002
PubMed ID: 12040188
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The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs.
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Immunobiology. 2002
PubMed ID: 11999340
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Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.
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Mol Biol Cell. 2001
PubMed ID: 11598189
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Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts.
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Blood. 2001
PubMed ID: 11159550
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Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
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Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals.
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Int J Biochem Cell Biol. 2001
PubMed ID: 11167132
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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Genome Res. 2000
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Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation.
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Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe.
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High-efficiency full-length cDNA cloning.
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Methods Enzymol. 1999
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Identification of reggie-1 and reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons.
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Gene. 1997
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Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins.
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Genomics. 1995
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J Biol Chem. 1994
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Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
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The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12.
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Genomics. 1991
PubMed ID: 1769667
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Biochemical diversity and evolution in the genus Mus.
Bonhomme F, Catalan J, Britton-Davidian J, Chapman VM, Moriwaki K, Nevo E, Thaler L
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