AKR1B1

Summary Top Help

Gene Description:

aldo-keto reductase family 1, member B1 (aldose reductase); aldo-keto reductase family 1, member B3 (aldose reductase)

Synonyms:

Aldor1, Akr1b1, ALDRED, Aldr1, ALR2, RATALDRED, ALDR1, AR, Alr, Akr1b4, AKR1B1, ALR-P-I, ADR, Ahr-1, Akr1b3, Ahr1

Orthologs:

Human AKR1B1 (protein-coding), Mouse Akr1b3 (protein-coding), Rat Akr1b1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm11	Rat	chr4:56920444..78042833	21.12	213

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr7:134127107..134144036 (16.93 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:34253930..34267497 (13.57 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:61645438..61659530 (149 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for AKR1B1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for AKR1B1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 6

Biocarta: None available

Reactome: 5

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 16

Publications from PubMed Top Help

Type 1 Diabetes Publications: 12

Association between (AC)n dinucleotide repeat polymorphism at the 5'-end of the aldose reductase gene and diabetic nephropathy: a meta-analysis.
Xu M, Chen X, Yan L, Cheng H, Chen W
J Mol Endocrinol. 2008
PubMed ID: 18434430
Evaluation of AC(n) and C(-106)T polymorphisms of the aldose reductase gene in Brazilian patients with DM1 and susceptibility to diabetic retinopathy.
Richeti F, Noronha RM, Waetge RT, de Vasconcellos JP, de Souza OF, Kneipp B, Assis N, Rocha MN, Calliari LE, Longui CA, Monte O, de Melo MB
Mol Vis. 2007
PubMed ID: 17563730
Identifying genetic susceptibilities to diabetes-related complications among individuals at low risk of complications: An application of tree-structured survival analysis.
Costacou T, Chang Y, Ferrell RE, Orchard TJ
Am J Epidemiol. 2006
PubMed ID: 16928730
Decline in neurophysiological function after 7 years in an adolescent diabetic cohort and the role of aldose reductase gene polymorphisms.
Thamotharampillai K, Chan AK, Bennetts B, Craig ME, Cusumano J, Silink M, Oates PJ, Donaghue KC
Diabetes Care. 2006
PubMed ID: 16936152
The association of aldose reductase gene (AKR1B1) polymorphisms with diabetic neuropathy in adolescents.
Donaghue KC, Margan SH, Chan AK, Holloway B, Silink M, Rangel T, Bennetts B
Diabet Med. 2005
PubMed ID: 16176189
Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients.
Lajer M, Tarnow L, Fleckner J, Hansen BV, Edwards DG, Parving HH, Boel E
Diabet Med. 2004
PubMed ID: 15270790
Diabetic nephropathy is associated with the 5'-end dinucleotide repeat polymorphism of the aldose reductase gene in Chinese subjects with Type 2 diabetes.
Liu YF, Wat NM, Chung SS, Ko BC, Lam KS
Diabet Med. 2002
PubMed ID: 11874426
Aldose reductase (AC)(n) microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabetes mellitus.
Ng DP, Conn J, Chung SS, Larkins RG
Diabetes Res Clin Pract. 2001
PubMed ID: 11182213
Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus.
Demaine A, Cross D, Millward A
Invest Ophthalmol Vis Sci. 2000
PubMed ID: 11095596
Aldose reductase gene expression is increased in diabetic nephropathy.
Shah VO, Dorin RI, Sun Y, Braun M, Zager PG
J Clin Endocrinol Metab. 1997
PubMed ID: 9215310
Increased white cell aldose reductase mRNA levels in diabetic patients.
Kicic E, Palmer TN
Diabetes Res Clin Pract. 1996
PubMed ID: 8877273
Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects.
Malone JI, Leavengood H, Peterson MJ, O'Brien MM, Page MG, Aldinger CE
Diabetes. 1984
PubMed ID: 6690344

Publications: 200

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Yang W, Thompson JW, Wang Z, Wang L, Sheng H, Foster MW, Moseley MA, Paschen W
J Proteome Res. 2012
PubMed ID: 22082260
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes.
Katakami N, Kaneto H, Takahara M, Matsuoka TA, Imamura K, Ishibashi F, Kanda T, Kawai K, Osonoi T, Matsuhisa M, Kashiwagi A, Kawamori R, Shimomura I, Yamasaki Y
Diabetes Res Clin Pract. 2011
PubMed ID: 21420193
Aldose reductase deficiency protects sugar-induced lens opacification in rats.
Reddy AB, Tammali R, Mishra R, Srivastava S, Srivastava SK, Ramana KV
Chem Biol Interact. 2011
PubMed ID: 21376710
Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds.
Shen Y, Zhong L, Johnson S, Cao D
Chem Biol Interact. 2011
PubMed ID: 21329684
Aldose reductase-mediated induction of epithelium-to-mesenchymal transition (EMT) in lens.
Zablocki GJ, Ruzycki PA, Overturf MA, Palla S, Reddy GB, Petrash JM
Chem Biol Interact. 2011
PubMed ID: 21329682
Aldose reductase (AKR1B3) regulates the accumulation of advanced glycosylation end products (AGEs) and the expression of AGE receptor (RAGE).
Baba SP, Hellmann J, Srivastava S, Bhatnagar A
Chem Biol Interact. 2011
PubMed ID: 21276777
Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats.
Kim CS, Kim J, Lee YM, Sohn E, Jo K, Kim JS
Arch Pharm Res. 2011
PubMed ID: 21656371
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo.
Tammali R, Reddy AB, Srivastava SK, Ramana KV
Angiogenesis. 2011
PubMed ID: 21409599
Catalytic mechanism of the primary human prostaglandin F2α synthase, aldo-keto reductase 1B1--prostaglandin D2 synthase activity in the absence of NADP(H).
Nagata N, Kusakari Y, Fukunishi Y, Inoue T, Urade Y
FEBS J. 2011
PubMed ID: 21306562
Glyoxalase I and aldose reductase gene polymorphisms and susceptibility to carotid atherosclerosis in type 2 diabetes.
Wu JC, Li XH, Wang JB, Tang JF, Wang YF, Peng YD
Genet Test Mol Biomarkers. 2011
PubMed ID: 21294693
Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation.
Kang ES, Iwata K, Ikami K, Ham SA, Kim HJ, Chang KC, Lee JH, Kim JH, Park SB, Kim JH, Yabe-Nishimura C, Seo HG
Free Radic Biol Med. 2011
PubMed ID: 21182935
The role of Cys-298 in aldose reductase function.
Balendiran GK, Sawaya MR, Schwarz FP, Ponniah G, Cuckovich R, Verma M, Cascio D
J Biol Chem. 2011
PubMed ID: 21084309
Genetic deficiency of aldose reductase counteracts the development of diabetic nephropathy in C57BL/6 mice.
Liu H, Luo Y, Zhang T, Zhang Y, Wu Q, Yuan L, Chung SS, Oates PJ, Yang JY
Diabetologia. 2011
PubMed ID: 21267539
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium.
Bresson E, Boucher-Kovalik S, Chapdelaine P, Madore E, Harvey N, Laberge PY, Leboeuf M, Fortier MA
J Clin Endocrinol Metab. 2011
PubMed ID: 20943776
Proteomic analysis of intestinal ischemia/reperfusion injury and ischemic preconditioning in rats reveals the protective role of aldose reductase.
Liu KX, Li C, Li YS, Yuan BL, Xu M, Xia Z, Huang WQ
Proteomics. 2010
PubMed ID: 21136599
Diabetic retinopathy: Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort.
Uthra S, Raman R, Mukesh BN, Rajkumar SA, Kumari P, Lakshmipathy P, Gnanamoorthy P, Sharma T, McCarty CA, Kumaramanickavel G
Ophthalmic Genet. 2010
PubMed ID: 21067489
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Aldose reductase is a potent regulator of TGF-β1 induced expression of fibronectin in human mesangial cells.
Huang P, Zhang Y, Jiang T, Zeng W, Zhang N
Mol Biol Rep. 2010
PubMed ID: 19847669
Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids.
Wetzelberger K, Baba SP, Thirunavukkarasu M, Ho YS, Maulik N, Barski OA, Conklin DJ, Bhatnagar A
J Biol Chem. 2010
PubMed ID: 20538586
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility.
Abhary S, Burdon KP, Laurie KJ, Thorpe S, Landers J, Goold L, Lake S, Petrovsky N, Craig JE
Diabetes Care. 2010
PubMed ID: 20424224
More severe type 2 diabetes-associated ischemic stroke injury is alleviated in aldose reductase-deficient mice.
Yeung CM, Lo AC, Cheung AK, Chung SS, Wong D, Chung SK
J Neurosci Res. 2010
PubMed ID: 20143423
Role of aldose reductase in the high glucose induced expression of fibronectin in human mesangial cells.
Huang P, Zhang Y, Jiang T, Zeng W, Zhang N
Mol Biol Rep. 2010
PubMed ID: 19821053
Role of aldose reductase in TGF-beta1-induced fibronectin synthesis in human mesangial cells.
Zhang Y, Huang P, Jiang T, Zhao J, Zhang N
Mol Biol Rep. 2010
PubMed ID: 19760097
Aldose reductase inhibition ameliorates the detrimental effect of estrogen replacement therapy on neuropathology in diabetic rats subjected to transient forebrain ischemia.
Shen B, Vetri F, Mao L, Xu HL, Paisansathan C, Pelligrino DA
Brain Res. 2010
PubMed ID: 20417192
Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis.
Gabbay KH, Bohren KM, Morello R, Bertin T, Liu J, Vogel P
J Biol Chem. 2010
PubMed ID: 20410296
Aldose reductase inhibition prevents lipopolysaccharide-induced glucose uptake and glucose transporter 3 expression in RAW264.7 macrophages.
Reddy AB, Srivastava SK, Ramana KV
Int J Biochem Cell Biol. 2010
PubMed ID: 20348015
Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle.
Tammali R, Saxena A, Srivastava SK, Ramana KV
Endocrinology. 2010
PubMed ID: 20308528
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.
Ramana KV, Tammali R, Srivastava SK
Mol Cancer Ther. 2010
PubMed ID: 20354121
The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice.
Yagihashi S, Mizukami H, Ogasawara S, Yamagishi S, Nukada H, Kato N, Hibi C, Chung S, Chung S
J Pathol. 2010
PubMed ID: 20112370
Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase.
Fujimori K, Ueno T, Nagata N, Kashiwagi K, Aritake K, Amano F, Urade Y
J Biol Chem. 2010
PubMed ID: 20093363
Autoimmunity in membranous nephropathy targets aldose reductase and SOD2.
Prunotto M, Carnevali ML, Candiano G, Murtas C, Bruschi M, Corradini E, Trivelli A, Magnasco A, Petretto A, Santucci L, Mattei S, Gatti R, Scolari F, Kador P, Allegri L, Ghiggeri GM
J Am Soc Nephrol. 2010
PubMed ID: 20150532
Aldose reductase deficiency improves Wallerian degeneration and nerve regeneration in diabetic thy1-YFP mice.
Chen YS, Chung SS, Chung SK
J Neuropathol Exp Neurol. 2010
PubMed ID: 20142761
Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy.
Balasubbu S, Sundaresan P, Rajendran A, Ramasamy K, Govindarajan G, Perumalsamy N, Hejtmancik JF
BMC Med Genet. 2010
PubMed ID: 21067572
Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.
Prasad P, Tiwari AK, Kumar KM, Ammini AC, Gupta A, Gupta R, Thelma BK
BMC Med Genet. 2010
PubMed ID: 20353610
Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance.
Muthenna P, Suryanarayana P, Gunda SK, Petrash JM, Reddy GB
FEBS Lett. 2009
PubMed ID: 19850041
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice.
Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A
Circ Res. 2009
PubMed ID: 19729598
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice.
Yadav UC, Naura AS, Aguilera-Aguirre L, Ramana KV, Boldogh I, Sur S, Boulares HA, Srivastava SK
J Immunol. 2009
PubMed ID: 19752229
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Regulation of AKR1B1 by thyroid hormone and its receptors.
Liao CS, Tai PJ, Huang YH, Chen RN, Wu SM, Kuo LW, Yeh CT, Tsai MM, Chen WJ, Lin KH
Mol Cell Endocrinol. 2009
PubMed ID: 19422879
Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.
Hirakawa H, Sawada H, Yamahama Y, Takikawa S, Shintaku H, Hara A, Mase K, Kondo T, Iino T
J Biochem. 2009
PubMed ID: 19273550
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).
Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
Nephrol Dial Transplant. 2009
PubMed ID: 19420105
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions.
Küper C, Steinert D, Fraek ML, Beck FX, Neuhofer W
Am J Physiol Renal Physiol. 2009
PubMed ID: 19225051
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation.
Tammali R, Reddy AB, Ramana KV, Petrash JM, Srivastava SK
Carcinogenesis. 2009
PubMed ID: 19028703
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice.
Yadav UC, Ramana KV, Aguilera-Aguirre L, Boldogh I, Boulares HA, Srivastava SK
PLoS One. 2009
PubMed ID: 19657391
Synergistic effect of osmotic and oxidative stress in slow-developing cataract formation.
Chan AW, Ho YS, Chung SK, Chung SS
Exp Eye Res. 2008
PubMed ID: 18760274
Aldose Reductase Genotypes and Cardio-Renal Complications - A 8-year Prospective Analysis of 1074 Type 2 Diabetic Patients.
So WY, Wang Y, Ng MC, Yang X, Ma RC, Lam V, Kong AP, Tong PC, Chan JC
Diabetes Care. 2008
PubMed ID: 18716049
Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
Steuber H, Heine A, Podjarny A, Klebe G
J Mol Biol. 2008
PubMed ID: 18495158
Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis.
Qiu L, Wu X, Chau JF, Szeto IY, Tam WY, Guo Z, Chung SK, Oates PJ, Chung SS, Yang JY
J Biol Chem. 2008
PubMed ID: 18445591
Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis.
Gleissner CA, Sanders JM, Nadler J, Ley K
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18451330
Cellular senescence bypass screen identifies new putative tumor suppressor genes.
Leal JF, Fominaya J, Cascón A, Guijarro MV, Blanco-Aparicio C, Lleonart M, Castro ME, Ramon Y Cajal S, Robledo M, Beach DH, Carnero A
Oncogene. 2008
PubMed ID: 17968325
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy.
Reddy GB, Satyanarayana A, Balakrishna N, Ayyagari R, Padma M, Viswanath K, Petrash JM
Mol Vis. 2008
PubMed ID: 18385795
Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.
Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y
Anal Sci. 2008
PubMed ID: 18187866
Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.
Jang DS, Lee GY, Kim YS, Lee YM, Kim CS, Yoo JL, Kim JS
Biol Pharm Bull. 2007
PubMed ID: 17978503
Gene deletion and pharmacological inhibition of aldose reductase protect against retinal ischemic injury.
Cheung AK, Lo AC, So KF, Chung SS, Chung SK
Exp Eye Res. 2007
PubMed ID: 17727843
Aldose reductase is implicated in high glucose-induced oxidative stress in mouse embryonic neural stem cells.
Fu J, Tay SS, Ling EA, Dheen ST
J Neurochem. 2007
PubMed ID: 17727625
Downregulation of renal TonEBP in hypokalemic rats.
Jeon US, Han KH, Park SH, Lee SD, Sheen MR, Jung JY, Kim WY, Sands JM, Kim J, Kwon HM
Am J Physiol Renal Physiol. 2007
PubMed ID: 17409277
Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.
Spite M, Baba SP, Ahmed Y, Barski OA, Nijhawan K, Petrash JM, Bhatnagar A, Srivastava S
Biochem J. 2007
PubMed ID: 17381426
The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop.
Biadene M, Hazemann I, Cousido A, Ginell S, Joachimiak A, Sheldrick GM, Podjarny A, Schneider TR
Acta Crystallogr D Biol Crystallogr. 2007
PubMed ID: 17505104
Evidence for a novel binding site conformer of aldose reductase in ligand-bound state.
Steuber H, Zentgraf M, La Motta C, Sartini S, Heine A, Klebe G
J Mol Biol. 2007
PubMed ID: 17418233
Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.
Steuber H, Heine A, Klebe G
J Mol Biol. 2007
PubMed ID: 17368668
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages.
Ramana KV, Reddy AB, Tammali R, Srivastava SK
Free Radic Biol Med. 2007
PubMed ID: 17382209
Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts.
Kador PF, Randazzo J, Babb T, Koushik K, Takamura Y, Zhu W, Blessing K, Kompella UB
J Ocul Pharmacol Ther. 2007
PubMed ID: 17444799
Sepiapterin reductase expression is increased in Parkinson's disease brain tissue.
Tobin JE, Cui J, Wilk JB, Latourelle JC, Laramie JM, McKee AC, Guttman M, Karamohamed S, DeStefano AL, Myers RH
Brain Res. 2007
PubMed ID: 17270157
Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis.
Hasuike Y, Moriguchi R, Hata R, Miyagawa K, Kuragano T, Aizawa M, Yamamoto S, Yanase K, Izumi M, Tanimoto T, Nakanishi T
Am J Nephrol. 2007
PubMed ID: 17851230
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Effect of quercetin on galactose-induced hyperglycaemic oxidative stress in hepatic and neuronal tissues of Wistar rats.
Ramana BV, Kumar VV, Krishna PN, Kumar CS, Reddy PU, Raju TN
Acta Diabetol. 2006
PubMed ID: 17211565
Ultrahigh-resolution study of protein atomic displacement parameters at cryotemperatures obtained with a helium cryostat.
Petrova T, Ginell S, Mitschler A, Hazemann I, Schneider T, Cousido A, Lunin VY, Joachimiak A, Podjarny A
Acta Crystallogr D Biol Crystallogr. 2006
PubMed ID: 17139089
Aldose reductase inhibitor zopolrestat restores allergic hyporesponsiveness in alloxan-diabetic rats.
Carvalho VF, Barreto EO, Serra MF, Cordeiro RS, Martins MA, Fortes ZB, e Silva PM
Eur J Pharmacol. 2006
PubMed ID: 16979157
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages.
Ramana KV, Fadl AA, Tammali R, Reddy AB, Chopra AK, Srivastava SK
J Biol Chem. 2006
PubMed ID: 16956889
C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy.
Olmos P, Bastías MJ, Vollrath V, Toro L, Trincado A, Salinas P, Claro JC, López JM, Acosta AM, Miquel JF, Castro J
Diabetes Res Clin Pract. 2006
PubMed ID: 16701918
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition.
Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, Bhatnagar A, Srivastava SK
Circulation. 2006
PubMed ID: 17030682
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells.
Tammali R, Ramana KV, Singhal SS, Awasthi S, Srivastava SK
Cancer Res. 2006
PubMed ID: 17018629
A selective aldose reductase inhibitor of a new structural class prevents or reverses early retinal abnormalities in experimental diabetic retinopathy.
Sun W, Oates PJ, Coutcher JB, Gerhardinger C, Lorenzi M
Diabetes. 2006
PubMed ID: 17003340
A global genomic transcriptional code associated with CNS-expressed genes.
Bailey PJ, Klos JM, Andersson E, Karlén M, Källström M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J
Exp Cell Res. 2006
PubMed ID: 16919269
The unfolded protein response in lens epithelial cells from galactosemic rat lenses.
Mulhern ML, Madson CJ, Danford A, Ikesugi K, Kador PF, Shinohara T
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 16936110
Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients.
Watarai A, Nakashima E, Hamada Y, Watanabe G, Naruse K, Miwa K, Kobayashi Y, Kamiya H, Nakae M, Hamajima N, Sekido Y, Niwa T, Oiso Y, Nakamura J
Diabet Med. 2006
PubMed ID: 16911628
Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.
Ho EC, Lam KS, Chen YS, Yip JC, Arvindakshan M, Yamagishi S, Yagihashi S, Oates PJ, Ellery CA, Chung SS, Chung SK
Diabetes. 2006
PubMed ID: 16804062
The -106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes.
dos Santos KG, Canani LH, Gross JL, Tschiedel B, Souto KE, Roisenberg I
Mol Genet Metab. 2006
PubMed ID: 16545977
Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism.
Yang JY, Tam WY, Tam S, Guo H, Wu X, Li G, Chau JF, Klein JD, Chung SK, Sands JM, Chung SS
Am J Physiol Renal Physiol. 2006
PubMed ID: 16449351
Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth.
Ramana KV, Bhatnagar A, Srivastava S, Yadav UC, Awasthi S, Awasthi YC, Srivastava SK
J Biol Chem. 2006
PubMed ID: 16648138
Redox activation of aldose reductase in the ischemic heart.
Kaiserova K, Srivastava S, Hoetker JD, Awe SO, Tang XL, Cai J, Bhatnagar A
J Biol Chem. 2006
PubMed ID: 16567803
Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats.
Yu J, Zhang Y, Sun S, Shen J, Qiu J, Yin X, Yin H, Jiang S
Can J Physiol Pharmacol. 2006
PubMed ID: 16900242
Aldose reductase regulates TGF-beta1-induced production of fibronectin and type IV collagen in cultured rat mesangial cells.
Jiang T, Che Q, Lin Y, Li H, Zhang N
Nephrology (Carlton). 2006
PubMed ID: 16669970
Variants in the gene encoding aldose reductase (AKR1B1) and diabetic nephropathy in American Indians.
Wolford JK, Yeatts KA, Red Eagle AR, Nelson RG, Knowler WC, Hanson RL
Diabet Med. 2006
PubMed ID: 16620264
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells.
Srivastava S, Ramana KV, Tammali R, Srivastava SK, Bhatnagar A
Diabetes. 2006
PubMed ID: 16567509
High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.
Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G
J Mol Biol. 2006
PubMed ID: 16337231
Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes.
Klepac N, Rudes Z, Klepac R
Biomed Pharmacother. 2006
PubMed ID: 16332428
The valine allele of the V89L polymorphism in the 5-alpha-reductase gene confers a reduced risk for hypospadias.
Thai HT, Kalbasi M, Lagerstedt K, Frisén L, Kockum I, Nordenskjöld A
J Clin Endocrinol Metab. 2005
PubMed ID: 16174723
Aldose reductase deficiency prevents diabetes-induced blood-retinal barrier breakdown, apoptosis, and glial reactivation in the retina of db/db mice.
Cheung AK, Fung MK, Lo AC, Lam TT, So KF, Chung SS, Chung SK
Diabetes. 2005
PubMed ID: 16249434
A two-dimensional electrophoresis reference map of human ovary.
Wang L, Zhu YF, Guo XJ, Huo R, Ma X, Lin M, Zhou ZM, Sha JH
J Mol Med. 2005
PubMed ID: 16021519
Antisense transcription in the mammalian transcriptome.
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Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
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Science. 2005
PubMed ID: 16141072
Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice.
Vikramadithyan RK, Hu Y, Noh HL, Liang CP, Hallam K, Tall AR, Ramasamy R, Goldberg IJ
J Clin Invest. 2005
PubMed ID: 16127462
Aldose reductase pathway mediates JAK-STAT signaling: a novel axis in myocardial ischemic injury.
Hwang YC, Shaw S, Kaneko M, Redd H, Marrero MB, Ramasamy R
FASEB J. 2005
PubMed ID: 15746188
[Association study between diabetic retinopathy and aldose reductase gene polymorphism in Tunisians]
Zghal-Mokni I, Arfa I, Elloumi-Zghal H, Abid A, Amrouche-Rached C, Kaabi B, Chakroun S, Blousa-Chabchoub S, Gaïgi S, Ayed S, Jeddi A, Dellagi K, Abdelhak S
J Fr Ophtalmol. 2005
PubMed ID: 15973199
Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians.
Petrovic MG, Peterlin B, Hawlina M, Petrovic D
J Diabetes Complications. 2005
PubMed ID: 15745835
Transcription factor Nrf2 regulates promoter activity of mouse aldose reductase (AKR1B3) gene.
Nishinaka T, Yabe-Nishimura C
J Pharmacol Sci. 2005
PubMed ID: 15655294
C-106T polymorphism in promoter of aldose reductase gene is a risk factor for diabetic nephropathy in type 2 diabetes patients with poor glycaemic control.
Gosek K, Moczulski D, Zukowska-Szczechowska E, Grzeszczak W
Nephron Exp Nephrol. 2005
PubMed ID: 15637423
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.
Payne AH, Hales DB
Endocr Rev. 2004
PubMed ID: 15583024
Aldose reductase gene polymorphisms and susceptibility to microvascular complications in Type 2 diabetes.
Sivenius K, Niskanen L, Voutilainen-Kaunisto R, Laakso M, Uusitupa M
Diabet Med. 2004
PubMed ID: 15569136
Association of glomerulopathy with the 5'-end polymorphism of the aldose reductase gene and renal insufficiency in type 2 diabetic patients.
Zhao HL, Tong PC, Lai FM, Tomlinson B, Chan JC
Diabetes. 2004
PubMed ID: 15504980
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells.
Ramana KV, Bhatnagar A, Srivastava SK
FASEB J. 2004
PubMed ID: 15284221
Central role for aldose reductase pathway in myocardial ischemic injury.
Hwang YC, Kaneko M, Bakr S, Liao H, Lu Y, Lewis ER, Yan S, Ii S, Itakura M, Rui L, Skopicki H, Homma S, Schmidt AM, Oates PJ, Szabolcs M, Ramasamy R
FASEB J. 2004
PubMed ID: 15284219
Aldose reductase gene polymorphisms and peripheral nerve function in patients with type 2 diabetes.
Sivenius K, Pihlajamäki J, Partanen J, Niskanen L, Laakso M, Uusitupa M
Diabetes Care. 2004
PubMed ID: 15277434
The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48.
Ruiz F, Hazemann I, Mitschler A, Joachimiak A, Schneider T, Karplus M, Podjarny A
Acta Crystallogr D Biol Crystallogr. 2004
PubMed ID: 15272156
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells.
Ramana KV, Bhatnagar A, Srivastava SK
FEBS Lett. 2004
PubMed ID: 15251463
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations.
Sotriffer CA, Krämer O, Klebe G
Proteins. 2004
PubMed ID: 15162486
Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumors.
Lefrançois-Martinez AM, Bertherat J, Val P, Tournaire C, Gallo-Payet N, Hyndman D, Veyssière G, Bertagna X, Jean C, Martinez A
J Clin Endocrinol Metab. 2004
PubMed ID: 15181092
Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A.
Howard EI, Sanishvili R, Cachau RE, Mitschler A, Chevrier B, Barth P, Lamour V, Van Zandt M, Sibley E, Bon C, Moras D, Schneider TR, Joachimiak A, Podjarny A
Proteins. 2004
PubMed ID: 15146478
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.
Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S
Br J Dermatol. 2004
PubMed ID: 14996095
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes: response to Wang et al.
P K Ng D, Chia KS, Koh D
Diabetes Care. 2004
PubMed ID: 14694018
Autoimmune hypoglycemia in a type 2 diabetic patient with anti-insulin and insulin receptor antibodies.
Kim CH, Park JH, Park TS, Baek HS
Diabetes Care. 2004
PubMed ID: 14694017
Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines.
Dan S, Shirakawa M, Mukai Y, Yoshida Y, Yamazaki K, Kawaguchi T, Matsuura M, Nakamura Y, Yamori T
Cancer Sci. 2003
PubMed ID: 14662023
C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus.
Makiishi T, Araki S, Koya D, Maeda S, Kashiwagi A, Haneda M
Am J Kidney Dis. 2003
PubMed ID: 14582038
Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol.
Galvez AS, Ulloa JA, Chiong M, Criollo A, Eisner V, Barros LF, Lavandero S
J Biol Chem. 2003
PubMed ID: 12881532
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
The DNA sequence of human chromosome 7.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
Nature. 2003
PubMed ID: 12853948
Human chromosome 7: DNA sequence and biology.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC
Science. 2003
PubMed ID: 12690205
Z-2 aldose reductase allele and diabetic retinopathy in India.
Kumaramanickavel G, Sripriya S, Ramprasad VL, Upadyay NK, Paul PG, Sharma T
Ophthalmic Genet. 2003
PubMed ID: 12660865
Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase.
Vander Jagt DL, Hunsaker LA
Chem Biol Interact. 2003
PubMed ID: 12604221
Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.
El-Kabbani O, Ramsland P, Darmanin C, Chung RP, Podjarny A
Proteins. 2003
PubMed ID: 12486717
Mechanical hyperalgesia in rat models of systemic and local hyperglycemia.
Dobretsov M, Hastings SL, Romanovsky D, Stimers JR, Zhang JM
Brain Res. 2003
PubMed ID: 12505670
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
Correlation between erythrocyte aldose reductase level and human diabetic retinopathy.
Oishi N, Kubo E, Takamura Y, Maekawa K, Tanimoto T, Akagi Y
Br J Ophthalmol. 2002
PubMed ID: 12446366
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells.
Ramana KV, Chandra D, Srivastava S, Bhatnagar A, Aggarwal BB, Srivastava SK
J Biol Chem. 2002
PubMed ID: 12063254
Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia.
Kawamura M, Eisenhofer G, Kopin IJ, Kador PF, Lee YS, Fujisawa S, Sato S
Auton Neurosci. 2002
PubMed ID: 11958479
Time- and dose-dependent differential upregulation of three genes by 17 beta-estradiol in endothelial cells.
Villablanca AC, Lewis KA, Rutledge JC
J Appl Physiol. 2002
PubMed ID: 11842041
(AC)(n) polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus.
Park HK, Ahn CW, Lee GT, Kim SJ, Song YD, Lim SK, Kim KR, Huh KB, Lee HC
Diabetes Res Clin Pract. 2002
PubMed ID: 11796181
Aldose reductase activation is a key component of myocardial response to ischemia.
Hwang YC, Sato S, Tsai JY, Yan S, Bakr S, Zhang H, Oates PJ, Ramasamy R
FASEB J. 2002
PubMed ID: 11772943
Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method.
Maekawa K, Tanimoto T, Okada S
Jpn J Pharmacol. 2002
PubMed ID: 11855672
Enhanced in situ expression of aldose reductase in peripheral nerve and renal glomeruli in diabetic patients.
Kasajima H, Yamagishi S, Sugai S, Yagihashi N, Yagihashi S
Virchows Arch. 2001
PubMed ID: 11499839
Expression and activities of aldo-keto oxidoreductases in Alzheimer disease.
Picklo MJ, Olson SJ, Markesbery WR, Montine TJ
J Neuropathol Exp Neurol. 2001
PubMed ID: 11444797
Association of retinopathy with a microsatellite at 5' end of the aldose reductase gene in Chinese patients with late-onset Type 2 diabetes.
Lee SC, Wang Y, Ko GT, Critchley JA, Ng MC, Tong PC, Cockram CS, Chan JC
Ophthalmic Genet. 2001
PubMed ID: 11449315
A vertebrate aldo-keto reductase active with retinoids and ethanol.
Crosas B, Cederlund E, Torres D, Jornvall H, Farres J, Pares X
J Biol Chem. 2001
PubMed ID: 11278684
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Regulation of vascular smooth muscle cell growth by aldose reductase.
Bhatnagar A, Ruef J, Liu S, Srivastava S, Srivastava SK
Chem Biol Interact. 2001
PubMed ID: 11306081
Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels.
Lahbib-Mansais Y, Leroux S, Milan D, Yerle M, Robic A, Jiang Z, André C, Gellin J
Mamm Genome. 2000
PubMed ID: 11130978
The mouse Kell blood group gene (Kel): cDNA sequence, genomic organization, expression, and enzymatic function.
Lee S, Russo DC, Pu J, Ho M, Redman CM
Immunogenetics. 2000
PubMed ID: 11132157
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis.
Aida K, Ikegishi Y, Chen J, Tawata M, Ito S, Maeda S, Onaya T
Biochem Biophys Res Commun. 2000
PubMed ID: 11032718
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.
Ho HT, Chung SK, Law JW, Ko BC, Tam SC, Brooks HL, Knepper MA, Chung SS
Mol Cell Biol. 2000
PubMed ID: 10913167
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.
O'connor T, Ireland LS, Harrison DJ, Hayes JD
Biochem J. 1999
PubMed ID: 10510318
Osmotic response element is required for the induction of aldose reductase by tumor necrosis factor-alpha.
Iwata T, Sato S, Jimenez J, McGowan M, Moroni M, Dey A, Ibaraki N, Reddy VN, Carper D
J Biol Chem. 1999
PubMed ID: 10075698
Characterization of genomic regions directing the cell-specific expression of the mouse aldose reductase gene.
Li H, Nobukuni Y, Gui T, Yabe-Nishimura C
Biochem Biophys Res Commun. 1999
PubMed ID: 10049784
Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.
Ho HT, Jenkins NA, Copeland NG, Gilbert DJ, Winkles JA, Louie HW, Lee FK, Chung SS, Chung SK
Eur J Biochem. 1999
PubMed ID: 10092857
Contributions of polyol pathway to oxidative stress in diabetic cataract.
Lee AY, Chung SS
FASEB J. 1999
PubMed ID: 9872926
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Developmental expression of urine concentration-associated genes and their altered expression in murine infantile-type polycystic kidney disease.
Gattone VH, Maser RL, Tian C, Rosenberg JM, Branden MG
Dev Genet. 1999
PubMed ID: 10322639
Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis.
Lu KP, Ramos KS
Biochem Biophys Res Commun. 1998
PubMed ID: 9918813
Identification and characterization of a novel human aldose reductase-like gene.
Cao D, Fan ST, Chung SS
J Biol Chem. 1998
PubMed ID: 9565553
Characterization of the mouse aldose reductase gene and promoter in a lens epithelial cell line.
McGowan MH, Iwata T, Carper DA
Mol Vis. 1998
PubMed ID: 9485485
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Harrison DH, Bohren KM, Petsko GA, Ringe D, Gabbay KH
Biochemistry. 1997
PubMed ID: 9405046
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.
Ko BC, Ruepp B, Bohren KM, Gabbay KH, Chung SS
J Biol Chem. 1997
PubMed ID: 9195951
Isolation of the mouse aldose reductase promoter and identification of a tonicity-responsive element.
Daoudal S, Tournaire C, Halere A, Veyssière G, Jean C
J Biol Chem. 1997
PubMed ID: 9006894
Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands.
Matsuura K, Deyashiki Y, Bunai Y, Ohya I, Hara A
Arch Biochem Biophys. 1996
PubMed ID: 8645003
Oxidized aldose reductase: in vivo factor not in vitro artifact.
Grimshaw CE, Lai CJ
Arch Biochem Biophys. 1996
PubMed ID: 8615700
An (A-C)n dinucleotide repeat polymorphic marker at the 5' end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients.
Ko BC, Lam KS, Wat NM, Chung SS
Diabetes. 1995
PubMed ID: 7789640
Long-term induction of an aldose reductase protein by basic fibroblast growth factor in rat astrocytes in vitro.
Laeng P, Bouillon P, Taupenot L, Labourdette G
Electrophoresis. 1995
PubMed ID: 7498172
Presence of a closely related subgroup in the aldo-ketoreductase family of the mouse.
Gui T, Tanimoto T, Kokai Y, Nishimura C
Eur J Biochem. 1995
PubMed ID: 7851421
Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes.
Jaquinod M, Potier N, Klarskov K, Reymann JM, Sorokine O, Kieffer S, Barth P, Andriantomanga V, Biellmann JF, Van Dorsselaer A
Eur J Biochem. 1993
PubMed ID: 8281941
Aldose and aldehyde reductases from human kidney cortex and medulla.
Robinson B, Hunsaker LA, Stangebye LA, Vander Jagt DL
Biochim Biophys Acta. 1993
PubMed ID: 8268209
Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.
Tarle I, Borhani DW, Wilson DK, Quiocho FA, Petrash JM
J Biol Chem. 1993
PubMed ID: 8245005
Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat.
Wilson DK, Tarle I, Petrash JM, Quiocho FA
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8234324
Identification of the reactive cysteine residue in human placenta aldose reductase.
Liu SQ, Bhatnagar A, Ansari NH, Srivastava SK
Biochim Biophys Acta. 1993
PubMed ID: 8343525
Aldose reductase in human retinal pigment epithelial cells.
Sato S, Lin LR, Reddy VN, Kador PF
Exp Eye Res. 1993
PubMed ID: 8405190
Quantitative determination of human aldose reductase by enzyme-linked immunosorbent assay. Immunoassay of human aldose reductase.
Nishimura C, Furue M, Ito T, Omori Y, Tanimoto T
Biochem Pharmacol. 1993
PubMed ID: 8347133
Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress.
Ferraretto A, Negri A, Giuliani A, De Grada L, Fuhrman Conti AM, Ronchi S
Biochim Biophys Acta. 1993
PubMed ID: 8435445
The crystal structure of the aldose reductase.NADPH binary complex.
Borhani DW, Harter TM, Petrash JM
J Biol Chem. 1992
PubMed ID: 1447221
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
Wilson DK, Bohren KM, Gabbay KH, Quiocho FA
Science. 1992
PubMed ID: 1621098
Characterization of the aldose reductase-encoding gene family in rat.
Graham C, Szpirer C, Levan G, Carper D
Gene. 1991
PubMed ID: 1748296
Structure of the human aldose reductase gene.
Graham A, Brown L, Hedge PJ, Gammack AJ, Markham AF
J Biol Chem. 1991
PubMed ID: 1901857
The human aldose reductase gene maps to chromosome region 7q35.
Graham A, Heath P, Morten JE, Markham AF
Hum Genet. 1991
PubMed ID: 1901827
In vitro expression of rat lens aldose reductase in Escherichia coli.
Old SE, Sato S, Kador PF, Carper DA
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2114645
Cloning and expression of human aldose reductase.
Nishimura C, Matsuura Y, Kokai Y, Akera T, Carper D, Morjana N, Lyons C, Flynn TG
J Biol Chem. 1990
PubMed ID: 2112546
Cloning and prokaryotic expression of a biologically active human placental aldose reductase.
Grundmann U, Bohn H, Obermeier R, Amann E
DNA Cell Biol. 1990
PubMed ID: 2111143
Nucleotide sequence of cDNA for human aldose reductase.
Graham A, Hedge PJ, Powell SJ, Riley J, Brown L, Gammack A, Carey F, Markham AF
Nucleic Acids Res. 1989
PubMed ID: 2510130
Cloning and sequence determination of human placental aldose reductase gene.
Chung S, LaMendola J
J Biol Chem. 1989
PubMed ID: 2504709
The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
Bohren KM, Bullock B, Wermuth B, Gabbay KH
J Biol Chem. 1989
PubMed ID: 2498333
Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine.
Morjana NA, Lyons C, Flynn TG
J Biol Chem. 1989
PubMed ID: 2492527
Aldose reductase and p-crystallin belong to the same protein superfamily as aldehyde reductase.
Carper D, Nishimura C, Shinohara T, Dietzchold B, Wistow G, Craft C, Kador P, Kinoshita JH
FEBS Lett. 1987
PubMed ID: 3111886
Interferon-induced guanylate-binding proteins: mapping of the murine Gbp-1 locus to chromosome 3.
Prochazka M, Staeheli P, Holmes RS, Haller O
Virology. 1985
PubMed ID: 3927587
Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7.
Mather PB, Holmes RS
Biochem Genet. 1985
PubMed ID: 3899099
Aldose reductase localization in human retinal mural cells.
Akagi Y, Kador PF, Kuwabara T, Kinoshita JH
Invest Ophthalmol Vis Sci. 1983
PubMed ID: 6417042
Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a new locus linked to the alcohol dehydrogenase gene complex on chromosome 3.
Duley JA, Holmes RS
Biochem Genet. 1982
PubMed ID: 6762206

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	231	11677	24192
EnsEMBL Gene(s)	ENSG00000085662	ENSMUSG00000001642	ENSRNOG00000009513
Unigene	Hs.521212	Mm.389126	Rn.107801
Homologene	AKR1B1	Akr1b3	Akr1b1
OMIM	103880	N/A	N/A
GeneCards	AKR1B1	N/A	N/A
Beta Cell Genomics	DT.100637594 DT.121060998 DT.448405 DT.91911063 DT.91938612 DT.92466151 DT.95182901 DT.95182923 DT.95182930	DT.101377110 DT.495566 DT.91597078 DT.94127579 DT.94339696	N/A
Reactome	P15121	N/A	N/A
Plasma Peptide Atlas	ENSP00000285930	N/A	N/A
WikiGenes	231	11677	24192

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
AKR1B1	DSP	IntAct	empirical	17353931
AKR1B1	GOT1	IntAct	empirical	15627969
AKR1B1	HLA-B	IntAct	empirical	17353931
AKR1B1	SMAD1	HPRD, MINT	empirical	15231748
AKR1B1	MCC	IntAct	empirical	17353931
AKR1B1	NPHP1	IntAct	empirical	21565611
AKR1B1	PAX7	IntAct	empirical	17353931
AKR1B1	PRKCE	IntAct	empirical	11139474
AKR1B1	ZNF253	IntAct	empirical	17353931
AKR1B1	CSMD1	IntAct	empirical	17353931
AKR1B1	SUMO3	BioGRID	empirical	22082260
AKR1B1	DST	IntAct	empirical	17353931
AKR1B1	TFE3	IntAct	empirical	17353931
AKR1B1	TRAF6	IntAct	empirical	17353931
AKR1B1	VHL	IntAct	empirical	17353931
AKR1B1	IKBKE	IntAct	empirical	17353931