FOXO1

Summary Top Help

Gene Description:

forkhead box O1

Synonyms:

FKHR, FKH1, Fkhr1, AI876417, Fkhr, Afxh, Foxo1, FOXO1A, Foxo1a, FOXO1

Orthologs:

Human FOXO1 (protein-coding), Mouse Foxo1 (protein-coding), Rat Foxo1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr13:41048131..41240734 (192.60 kb) View in Genome Browser

(Mouse) NCBIM37 - chr3:52072259..52154031 (81.77 kb) View in Genome Browser

(Rat) RGSC3.4 - chr2:141127345..141203446 (76.10 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for FOXO1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for FOXO1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: 1

Reactome: 9

NCI-Nature Pathway Interaction Database: 8

Gene Ontology: 31

Publications from PubMed Top Help

Type 1 Diabetes Publications: 41

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription.
Alejandro EU, Lim GE, Mehran AE, Hu X, Taghizadeh F, Pelipeychenko D, Baccarini M, Johnson JD
FASEB J. 2011
PubMed ID: 21817126
Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway.
Li J, Chi Y, Wang C, Wu J, Yang H, Zhang D, Zhu Y, Wang N, Yang J, Guan Y
Hepatology. 2011
PubMed ID: 21412813
FoxO1: A molecule for all seasons.
Kousteni S
J Bone Miner Res. 2011
PubMed ID: 21541992
Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic β-cells dysfunction.
Chen F, Zhu Y, Tang X, Sun Y, Jia W, Sun Y, Han X
Endocrinology. 2011
PubMed ID: 21385937
Nucleo-cytosolic shuttling of FOXO1 directly regulates mouse INS2 but not INS1 gene expression in pancreatic beta cells (min6).
Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA
J Biol Chem. 2011
PubMed ID: 21335550
FoxO1 and SIRT1 regulate {beta}-cell responses to nitric oxide.
Hughes KJ, Meares GP, Hansen PA, Corbett JA
J Biol Chem. 2011
PubMed ID: 21196578
Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.
Kluth O, Mirhashemi F, Scherneck S, Kaiser D, Kluge R, Neschen S, Joost HG, Schürmann A
Diabetologia. 2010
PubMed ID: 21107520
Advanced glycation end-products affect transcription factors regulating insulin gene expression.
Puddu A, Storace D, Odetti P, Viviani GL
Biochem Biophys Res Commun. 2010
PubMed ID: 20353756
TNF-alpha mediates diabetes enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO-1.
Kayal RA, Siqueira M, Alblowi J, McLean J, Krothapalli N, Faibish D, Einhorn TA, Gerstenfeld LC, Graves DT
J Bone Miner Res. 2010
PubMed ID: 20200974
Effect of forkhead box O1 (FOXO1) on beta cell development in the human fetal pancreas.
Al-Masri M, Krishnamurthy M, Li J, Fellows GF, Dong HH, Goodyer CG, Wang R
Diabetologia. 2009
PubMed ID: 20033803
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice.
Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, Depinho RA, Kim JK, Karsenty G, Kousteni S
J Clin Invest. 2009
PubMed ID: 20038793
The FoxO/Bcl-6/cyclin D2 pathway mediates metabolic and growth factor stimulation of proliferation in Min6 pancreatic beta-cells.
Glauser DA, Schlegel W
J Recept Signal Transduct Res. 2009
PubMed ID: 19929250
Atrial natriuretic peptide promotes pancreatic islet beta-cell growth and Akt/Foxo1a/cyclin D2 signaling.
You H, Laychock SG
Endocrinology. 2009
PubMed ID: 19837876
Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic beta-cells.
Wang W, Liu Y, Chen Y, Cao C, Xiang Y, Zhang D, Han L, Zhao H, Liu G
Peptides. 2009
PubMed ID: 19944124
Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1).
Siqueira MF, Li J, Chehab L, Desta T, Chino T, Krothpali N, Behl Y, Alikhani M, Yang J, Braasch C, Graves DT
Diabetologia. 2009
PubMed ID: 19902175
Forkhead Box O1/Pancreatic and Duodenal Homeobox 1 Intracellular Translocation Is Regulated by c-Jun N-Terminal Kinase and Involved in Prostaglandin E2-Induced Pancreatic {beta}-Cell Dysfunction.
Meng Z, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X
Endocrinology. 2009
PubMed ID: 19837872
Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.
Westmoreland JJ, Wang Q, Bouzaffour M, Baker SJ, Sosa-Pineda B
Dev Biol. 2009
PubMed ID: 19635472
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.
Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D
Mol Cell Biol. 2009
PubMed ID: 19506018
FOXO1 plays an important role in enhanced microvascular cell apoptosis and microvascular cell loss in type 1 and type 2 diabetic rats.
Behl Y, Krothapalli P, Desta T, Roy S, Graves DT
Diabetes. 2009
PubMed ID: 19168598
Association of common genetic variation in the FOXO1 gene with {beta}-cell dysfunction, impaired glucose tolerance, and type 2 diabetes.
Müssig K, Staiger H, Machicao F, Stancakova A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU
J Clin Endocrinol Metab. 2009
PubMed ID: 19141580
The transcription factor COUP-TFII is negatively regulated by insulin and glucose via Foxo1 and ChREBP controlled pathways.
Perilhou A, Tourrel-Cuzin C, Kharroubi I, Henique C, Fauveau V, Kitamura T, Magnan C, Postic C, Prip-Buus C, Vasseur-Cognet M
Mol Cell Biol. 2008
PubMed ID: 18765640
Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis.
Martinez SC, Tanabe K, Cras-Méneur C, Abumrad NA, Bernal-Mizrachi E, Permutt MA
Diabetes. 2008
PubMed ID: 18174526
Orexin-A inhibits glucagon secretion and gene expression through a Foxo1-dependent pathway.
Göncz E, Strowski MZ, Grötzinger C, Nowak KW, Kaczmarek P, Sassek M, Mergler S, El-Zayat BF, Theodoropoulou M, Stalla GK, Wiedenmann B, Plöckinger U
Endocrinology. 2008
PubMed ID: 18162514
Pancreatic glucokinase is activated by insulin-like growth factor-I.
Yoshida K, Murao K, Imachi H, Cao WM, Yu X, Li J, Ahmed RA, Kitanaka N, Wong NC, Unterman TG, Magnuson MA, Ishida T
Endocrinology. 2007
PubMed ID: 17317782
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H
Cell Metab. 2007
PubMed ID: 17339028
Metabolic diapause in pancreatic beta-cells expressing a gain-of-function mutant of the forkhead protein Foxo1.
Buteau J, Shlien A, Foisy S, Accili D
J Biol Chem. 2007
PubMed ID: 17107961
Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.
Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J
J Biol Chem. 2006
PubMed ID: 17077083
FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells.
McKinnon CM, Ravier MA, Rutter GA
J Biol Chem. 2006
PubMed ID: 17062568
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.
Guo S, Dunn SL, White MF
Mol Endocrinol. 2006
PubMed ID: 16916938
Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell.
Martinez SC, Cras-Méneur C, Bernal-Mizrachi E, Permutt MA
Diabetes. 2006
PubMed ID: 16731820
Analysis of FOXO1A as a candidate gene for type 2 diabetes.
Karim MA, Craig RL, Wang X, Hale TC, Elbein SC
Mol Genet Metab. 2006
PubMed ID: 16497530
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
Buteau J, Spatz ML, Accili D
Diabetes. 2006
PubMed ID: 16644672
Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass.
Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W, Fujimoto Y, Okamura H, Arden KC, Herrera PL, Noda T, Kasuga M
Nat Genet. 2006
PubMed ID: 16642023
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.
Kitamura T, Feng Y, Kitamura YI, Chua SC, Xu AW, Barsh GS, Rossetti L, Accili D
Nat Med. 2006
PubMed ID: 16604086
Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance.
Okamoto H, Hribal ML, Lin HV, Bennett WR, Ward A, Accili D
J Clin Invest. 2006
PubMed ID: 16485043
The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation.
Kawamori D, Kaneto H, Nakatani Y, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y
J Biol Chem. 2006
PubMed ID: 16282329
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D
Cell Metab. 2005
PubMed ID: 16154098
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regu
Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH
J Biol Chem. 2005
PubMed ID: 15817464
Mosaic analysis of insulin receptor function.
Kitamura T, Kitamura Y, Nakae J, Giordano A, Cinti S, Kahn CR, Efstratiadis A, Accili D
J Clin Invest. 2004
PubMed ID: 14722613
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D
J Clin Invest. 2002
PubMed ID: 12488434
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D
Nat Genet. 2002
PubMed ID: 12219087

Publications: 458

PGC-1α and FOXO1 mRNA levels and fiber characteristics of the soleus and plantaris muscles in rats after hindlimb unloading.
Nagatomo F, Fujino H, Kondo H, Suzuki H, Kouzaki M, Takeda I, Ishihara A
Histol Histopathol. 2011
PubMed ID: 21972093
Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis.
Tsuchiya K, Banks AS, Liang CP, Tabas I, Tall AR, Accili D
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21940942
Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P
Dev Biol. 2011
PubMed ID: 21884692
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.
Banks AS, Kim-Muller JY, Mastracci TL, Kofler NM, Qiang L, Haeusler RA, Jurczak MJ, Laznik D, Heinrich G, Samuel VT, Shulman GI, Papaioannou VE, Accili D
Cell Metab. 2011
PubMed ID: 22055502
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.
Tzivion G, Dobson M, Ramakrishnan G
Biochim Biophys Acta. 2011
PubMed ID: 21708191
The PKB/FOXO switch in aging and cancer.
Kloet DE, Burgering BM
Biochim Biophys Acta. 2011
PubMed ID: 21539865
Interplay between FOXO, TOR, and Akt.
Hay N
Biochim Biophys Acta. 2011
PubMed ID: 21440577
Akt, FoxO and regulation of apoptosis.
Zhang X, Tang N, Hadden TJ, Rishi AK
Biochim Biophys Acta. 2011
PubMed ID: 21440011
Regulation of FoxO transcription factors by acetylation and protein-protein interactions.
Daitoku H, Sakamaki J, Fukamizu A
Biochim Biophys Acta. 2011
PubMed ID: 21396404
CNK1 and other scaffolds for Akt/FoxO signaling.
Fritz RD, Radziwill G
Biochim Biophys Acta. 2011
PubMed ID: 21320536
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
Huang H, Tindall DJ
Biochim Biophys Acta. 2011
PubMed ID: 21238503
The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.
Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21972416
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ
Cell Metab. 2011
PubMed ID: 21982711
Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways.
Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH
Endocrinology. 2011
PubMed ID: 21862615
Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation.
Wu JB, Shih JC
Mol Pharmacol. 2011
PubMed ID: 21775495
FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma.
Liu J, Guzman MA, Pezanowski D, Patel D, Hauptman J, Keisling M, Hou SJ, Papenhausen PR, Pascasio JM, Punnett HH, Halligan GE, de Chadarévian JP
Mod Pathol. 2011
PubMed ID: 21666686
Forkhead factor FoxO1 is essential for placental morphogenesis in the developing embryo.
Ferdous A, Morris J, Abedin MJ, Collins S, Richardson JA, Hill JA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21930913
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT
Cell. 2011
PubMed ID: 21884932
STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.
Oh HM, Yu CR, Golestaneh N, Amadi-Obi A, Lee YS, Eseonu A, Mahdi RM, Egwuagu CE
J Biol Chem. 2011
PubMed ID: 21730069
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Goertz MJ, Wu Z, Gallardo TD, Hamra FK, Castrillon DH
J Clin Invest. 2011
PubMed ID: 21865646
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.
Zhang X, Yalcin S, Lee DF, Yeh TY, Lee SM, Su J, Mungamuri SK, Rimmelé P, Kennedy M, Sellers R, Landthaler M, Tuschl T, Chi NW, Lemischka I, Keller G, Ghaffari S
Nat Cell Biol. 2011
PubMed ID: 21804543
Dehydroepiandrosterone-induced phosphorylation and translocation of FoxO1 depend on the mineralocorticoid receptor.
Lindschau C, Kirsch T, Klinge U, Kolkhof P, Peters I, Fiebeler A
Hypertension. 2011
PubMed ID: 21747041
SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL.
Chakrabarti P, English T, Karki S, Qiang L, Tao R, Kim J, Luo Z, Farmer SR, Kandror KV
J Lipid Res. 2011
PubMed ID: 21743036
Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway.
Deng L, Shoji I, Ogawa W, Kaneda S, Soga T, Jiang DP, Ide YH, Hotta H
J Virol. 2011
PubMed ID: 21697492
FoxO family members in cancer.
Zhang Y, Gan B, Liu D, Paik JH
Cancer Biol Ther. 2011
PubMed ID: 21613825
Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells.
Zhang Y, Wang C
Oncogene. 2011
PubMed ID: 21423212
Evolution of a derived protein-protein interaction between HoxA11 and Foxo1a in mammals caused by changes in intramolecular regulation.
Brayer KJ, Lynch VJ, Wagner GP
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21788518
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D
Nat Med. 2011
PubMed ID: 21804540
Cdc25A regulates matrix metalloprotease 1 through Foxo1 and mediates metastasis of breast cancer cells.
Feng X, Wu Z, Wu Y, Hankey W, Prior TW, Li L, Ganju RK, Shen R, Zou X
Mol Cell Biol. 2011
PubMed ID: 21670150
Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.
Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A
Aging Cell. 2011
PubMed ID: 21388494
Comparison of gene expression profiles reveals aberrant expression of FOXO1, Aurora A/B and EZH2 in lesional psoriatic skins.
Liu Y, Luo W, Chen S
Mol Biol Rep. 2011
PubMed ID: 21116854
Cardiac triglyceride accumulation following acute lipid excess occurs through activation of a FoxO1-iNOS-CD36 pathway.
Puthanveetil P, Wang Y, Zhang D, Wang F, Kim MS, Innis S, Pulinilkunnil T, Abrahani A, Rodrigues B
Free Radic Biol Med. 2011
PubMed ID: 21545834
Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells.
Wen Q, Duan X, Liao R, Little P, Gao G, Jiang H, Lalit S, Quirion R, Zheng W
Neurosci Lett. 2011
PubMed ID: 21549807
Association analyses between the genetic polymorphisms of HNF4A and FOXO1 genes and Chinese Han patients with type 2 diabetes.
Li T, Wu X, Zhu X, Li J, Pan L, Li P, Xin Z, Liu Y
Mol Cell Biochem. 2011
PubMed ID: 21442235
SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells.
Chae HD, Broxmeyer HE
Stem Cells Dev. 2011
PubMed ID: 21083429
FoxO regulates expression of decidual protein induced by progesterone (DEPP) in human endothelial cells.
Chen S, Gai J, Wang Y, Li H
FEBS Lett. 2011
PubMed ID: 21510935
Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor.
Gonzalez E, Flier E, Molle D, Accili D, McGraw TE
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21646544
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Tumor necrosis factor-α increases angiopoietin-like protein 2 gene expression by activating Foxo1 in 3T3-L1 adipocytes.
Zheng JY, Zou JJ, Wang WZ, Feng XY, Shi YY, Zhao Y, Jin G, Liu ZM
Mol Cell Endocrinol. 2011
PubMed ID: 21501655
Differential gene expression of FoxO1, ID1, and ID3 between young and older men and associations with muscle mass and function.
Buford TW, Cooke MB, Shelmadine BD, Hudson GM, Redd LL, Willoughby DS
Aging Clin Exp Res. 2011
PubMed ID: 21993163
Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells.
Feng X, Wang H, Takata H, Day TJ, Willen J, Hu H
Nat Immunol. 2011
PubMed ID: 21532575
Expression pattern of the FoxO1 gene during mouse embryonic development.
Villarejo-Balcells B, Guichard S, Rigby PW, Carvajal JJ
Gene Expr Patterns. 2011
PubMed ID: 21397048
In search of CML stem cells' deadly weakness.
Pellicano F, Sinclair A, Holyoake TL
Curr Hematol Malig Rep. 2011
PubMed ID: 21373837
Anti-inflammatory effect of insulin in the human hepatoma cell line HepG2 involves decreased transcription of IL-6 target genes and nuclear exclusion of FOXO1.
Wallerstedt E, Sandqvist M, Smith U, Andersson CX
Mol Cell Biochem. 2011
PubMed ID: 21298325
Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts.
Yang S, Xu H, Yu S, Cao H, Fan J, Ge C, Fransceschi RT, Dong HH, Xiao G
J Biol Chem. 2011
PubMed ID: 21471200
β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
Paek H, Hwang JY, Zukin RS, Hébert JM
Dev Cell. 2011
PubMed ID: 21571225
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis.
Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ
Cell. 2011
PubMed ID: 21565617
FOXO1 inhibits Runx2 transcriptional activity and prostate cancer cell migration and invasion.
Zhang H, Pan Y, Zheng L, Choe C, Lindgren B, Jensen ED, Westendorf JJ, Cheng L, Huang H
Cancer Res. 2011
PubMed ID: 21505104
Pax7-FKHR transcriptional activity is enhanced by transcriptionally repressed MyoD.
Olguín HC, Patzlaff NE, Olwin BB
J Cell Biochem. 2011
PubMed ID: 21321994
FOXO1 modulates osteoblast differentiation.
Siqueira MF, Flowers S, Bhattacharya R, Faibish D, Behl Y, Kotton DN, Gerstenfeld L, Moran E, Graves DT
Bone. 2011
PubMed ID: 21281751
Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus.
VanDunk C, Hunter LA, Gray PA
J Neurosci. 2011
PubMed ID: 21525287
Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene.
Tao R, Wei D, Gao H, Liu Y, DePinho RA, Dong XC
J Biol Chem. 2011
PubMed ID: 21388966
Ceruloplasmin expression in rat liver cells is attenuated by insulin: role of FoxO transcription factors.
Leyendecker M, Korsten P, Reinehr R, Speckmann B, Schmoll D, Scherbaum WA, Bornstein SR, Barthel A, Klotz LO
Horm Metab Res. 2011
PubMed ID: 21332026
FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress.
Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE
J Biol Chem. 2011
PubMed ID: 21159781
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction.
Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U
Nat Med. 2011
PubMed ID: 21317886
Protein kinase A-alpha directly phosphorylates FoxO1 in vascular endothelial cells to regulate expression of vascular cellular adhesion molecule-1 mRNA.
Lee JW, Chen H, Pullikotil P, Quon MJ
J Biol Chem. 2011
PubMed ID: 21177856
FoxO1 mediates an autofeedback loop regulating SIRT1 expression.
Xiong S, Salazar G, Patrushev N, Alexander RW
J Biol Chem. 2011
PubMed ID: 21149440
JNK regulates FoxO-dependent autophagy in neurons.
Xu P, Das M, Reilly J, Davis RJ
Genes Dev. 2011
PubMed ID: 21325132
Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase.
Szypowska AA, de Ruiter H, Meijer LA, Smits LM, Burgering BM
Antioxid Redox Signal. 2011
PubMed ID: 20874444
Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle.
Milkiewicz M, Roudier E, Doyle JL, Trifonova A, Birot O, Haas TL
Am J Pathol. 2011
PubMed ID: 21281824
Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner.
Valis K, Prochazka L, Boura E, Chladova J, Obsil T, Rohlena J, Truksa J, Dong LF, Ralph SJ, Neuzil J
Cancer Res. 2011
PubMed ID: 21245099
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Mol Cell Neurosci. 2011
PubMed ID: 21194568
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.
Wei D, Tao R, Zhang Y, White MF, Dong XC
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21081708
FoxO1 regulates muscle fiber-type specification and inhibits calcineurin signaling during C2C12 myoblast differentiation.
Yuan Y, Shi XE, Liu YG, Yang GS
Mol Cell Biochem. 2011
PubMed ID: 21080037
Tumor necrosis factor-α regulates p27 kip expression and apoptosis in smooth muscle cells of human carotid plaques via forkhead transcription factor O1.
Jia G, Aggarwal A, Tyndall SH, Agrawal DK
Exp Mol Pathol. 2011
PubMed ID: 21075101
FOXO1 stimulates ceruloplasmin promoter activity in human hepatoma cells treated with IL-6.
Sidhu A, Miller PJ, Hollenbach AD
Biochem Biophys Res Commun. 2011
PubMed ID: 21185807
14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.
Su YW, Hao Z, Hirao A, Yamamoto K, Lin WJ, Young A, Duncan GS, Yoshida H, Wakeham A, Lang PA, Murakami K, Ohashi P, Mak TW
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21205887
Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.
Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi S
PLoS One. 2011
PubMed ID: 21991327
Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules.
Kim SY, Yoon J, Ko YS, Chang MS, Park JW, Lee HE, Kim MA, Kim JH, Kim WH, Lee BL
BMC Cancer. 2011
PubMed ID: 21696576
PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh GS, Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, Nakae J
PLoS One. 2011
PubMed ID: 21694754
Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells.
Chen Z, Xiao Y, Zhang J, Li J, Liu Y, Zhao Y, Ma C, Luo J, Qiu Y, Huang G, Korteweg C, Gu J
PLoS One. 2011
PubMed ID: 21655267
Wnt signaling regulates hepatic metabolism.
Liu H, Fergusson MM, Wu JJ, Rovira II, Liu J, Gavrilova O, Lu T, Bao J, Han D, Sack MN, Finkel T
Sci Signal. 2011
PubMed ID: 21285411
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
Gene Expr Patterns. 2011
PubMed ID: 20932939
IRIZIO: a Novel Gene Cooperating with PAX3-FOXO1 in Alveolar Rhabdomyosarcoma (ARMS).
Picchione F, Pritchard C, Lagutina I, Janke L, Grosveld GC
Carcinogenesis. 2010
PubMed ID: 21177767
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages.
Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky JM
EMBO J. 2010
PubMed ID: 21045807
Foxo transcription factors control regulatory T cell development and function.
Kerdiles YM, Stone EL, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM
Immunity. 2010
PubMed ID: 21167754
Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.
Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J
Circ Res. 2010
PubMed ID: 20947830
Effects of FOXO genotypes on longevity: a biodemographic analysis.
Zeng Y, Cheng L, Chen H, Cao H, Hauser ER, Liu Y, Xiao Z, Tan Q, Tian XL, Vaupel JW
J Gerontol A Biol Sci Med Sci. 2010
PubMed ID: 20884733
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis. 2010
PubMed ID: 20819778
Roles of FoxO1 and Sirt1 in the central regulation of food intake.
Sasaki T, Kitamura T
Endocr J. 2010
PubMed ID: 21048357
FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis.
Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, Signoretti S, DePinho RA
Cancer Cell. 2010
PubMed ID: 21075312
FoxOs function synergistically to promote glucose production.
Haeusler RA, Kaestner KH, Accili D
J Biol Chem. 2010
PubMed ID: 20880840
FOXO1 is a direct target of EWS-Fli1 oncogenic fusion protein in Ewing's sarcoma cells.
Yang L, Hu HM, Zielinska-Kwiatkowska A, Chansky HA
Biochem Biophys Res Commun. 2010
PubMed ID: 20933505
MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice.
Wu Z, Jiao P, Huang X, Feng B, Feng Y, Yang S, Hwang P, Du J, Nie Y, Xiao G, Xu H
J Clin Invest. 2010
PubMed ID: 20921625
New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.
Vitart V, Bencić G, Hayward C, Skunca Herman J, Huffman J, Campbell S, Bućan K, Navarro P, Gunjaca G, Marin J, Zgaga L, Kolcić I, Polasek O, Kirin M, Hastie ND, Wilson JF, Rudan I, Campbell H, Vatavuk Z, Fleck B, Wright A
Hum Mol Genet. 2010
PubMed ID: 20719862
FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells.
Liu X, Qiao A, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, Fang F
FEBS Lett. 2010
PubMed ID: 20868688
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group
Diabetes. 2010
PubMed ID: 20682687
Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis.
Teixeira CC, Liu Y, Thant LM, Pang J, Palmer G, Alikhani M
J Biol Chem. 2010
PubMed ID: 20650891
Involvement of FKHR (FOXO1) transcription factor in human uterus leiomyoma growth.
Kovács KA, Lengyel F, Wilhelm F, Vértes Z, Sumegi B, Vértes M
Fertil Steril. 2010
PubMed ID: 19772960
Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia.
Haeusler RA, Han S, Accili D
J Biol Chem. 2010
PubMed ID: 20573950
Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization.
Qiang L, Banks AS, Accili D
J Biol Chem. 2010
PubMed ID: 20519497
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B
Mol Cell. 2010
PubMed ID: 20705244
FoxO1 links hepatic insulin action to endoplasmic reticulum stress.
Kamagate A, Kim DH, Zhang T, Slusher S, Gramignoli R, Strom SC, Bertera S, Ringquist S, Dong HH
Endocrinology. 2010
PubMed ID: 20501674
Impaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoprotein.
Wu K, Cappel D, Martinez M, Stafford JM
Endocrinology. 2010
PubMed ID: 20501667
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.
Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G
Cell. 2010
PubMed ID: 20655470
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells.
Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC
J Exp Med. 2010
PubMed ID: 20439537
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
Zhao Y, Yang J, Liao W, Liu X, Zhang H, Wang S, Wang D, Feng J, Yu L, Zhu WG
Nat Cell Biol. 2010
PubMed ID: 20543840
A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate.
Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C
Nat Immunol. 2010
PubMed ID: 20543837
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.
Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO
Nat Immunol. 2010
PubMed ID: 20467422
Foxo1 regulates marginal zone B-cell development.
Chen J, Limon JJ, Blanc C, Peng SL, Fruman DA
Eur J Immunol. 2010
PubMed ID: 20449867
Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome.
Kohan K, Carvajal R, Gabler F, Vantman D, Romero C, Vega M
Reproduction. 2010
PubMed ID: 20406953
Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4alpha pathway in insulin resistant mice.
De Souza CT, Frederico MJ, da Luz G, Cintra DE, Ropelle ER, Pauli JR, Velloso LA
J Physiol. 2010
PubMed ID: 20421289
Isolation of putative FOXO1 genomic elements using an improved in vitro technique to isolate genomic regulatory sequences.
Sidhu A, Miller PJ, Hollenbach AD
Gene. 2010
PubMed ID: 20338229
[Significance and expression of FKHR and AKT after subarachnoid hemorrhage in rat brain cortex].
Miao CM, Luo Q, Wang WW, Kang JS, Shi GY, Li HY, Zhang Y
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20973227
Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression.
Banerjee A, Meyer K, Mazumdar B, Ray RB, Ray R
J Virol. 2010
PubMed ID: 20357092
FoxO1 is involved in the antineoplastic effect of calorie restriction.
Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I
Aging Cell. 2010
PubMed ID: 20222901
Role of dephosphorylation of FOXO1 on apoptosis induced by wortmannin for non-Hodgkin's lymphoma cells.
Qiong Z, Ruofan H, Xiaohua L, Xinli Z, Jingwei J, Zhaohui C
Mol Biol Rep. 2010
PubMed ID: 19757185
Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma.
Williamson D, Missiaglia E, de Reyniès A, Pierron G, Thuille B, Palenzuela G, Thway K, Orbach D, Laé M, Fréneaux P, Pritchard-Jones K, Oberlin O, Shipley J, Delattre O
J Clin Oncol. 2010
PubMed ID: 20351326
IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression.
Yoshida T, Semprun-Prieto L, Sukhanov S, Delafontaine P
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20228261
Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans.
Felder TK, Hahne P, Soyal SM, Miller K, Höffinger H, Oberkofler H, Krempler F, Patsch W
Int J Obes (Lond). 2010
PubMed ID: 20125105
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism.
Smith IJ, Alamdari N, O'Neal P, Gonnella P, Aversa Z, Hasselgren PO
Int J Biochem Cell Biol. 2010
PubMed ID: 20079455
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N
Dev Cell. 2010
PubMed ID: 20412774
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.
Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S, Itoh H, Noda T, Kasuga M, Nakae J
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20103739
FOXO1 and TCF7L2 genes involved in metastasis and poor prognosis in clear cell renal cell carcinoma.
Kojima T, Shimazui T, Horie R, Hinotsu S, Oikawa T, Kawai K, Suzuki H, Meno K, Akaza H, Uchida K
Genes Chromosomes Cancer. 2010
PubMed ID: 20095040
The cathepsin L gene is a direct target of FOXO1 in skeletal muscle.
Yamazaki Y, Kamei Y, Sugita S, Akaike F, Kanai S, Miura S, Hirata Y, Troen BR, Kitamura T, Nishino I, Suganami T, Ezaki O, Ogawa Y
Biochem J. 2010
PubMed ID: 20088826
Regulation of FOXO1 by TAK1-Nemo-like kinase pathway.
Kim S, Kim Y, Lee J, Chung J
J Biol Chem. 2010
PubMed ID: 20061393
Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.
Cameron AR, Anil S, Sutherland E, Harthill J, Rena G
Metallomics. 2010
PubMed ID: 21069157
Pivotal role of JNK-dependent FOXO1 activation in downregulation of kallistatin expression by oxidative stress.
Shen B, Chao L, Chao J
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20081110
Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator family.
Sumegi J, Streblow R, Frayer RW, Dal Cin P, Rosenberg A, Meloni-Ehrig A, Bridge JA
Genes Chromosomes Cancer. 2010
PubMed ID: 19953635
FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells.
Samarin J, Wessel J, Cicha I, Kroening S, Warnecke C, Goppelt-Struebe M
J Biol Chem. 2010
PubMed ID: 20018872
FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts.
Rached MT, Kode A, Xu L, Yoshikawa Y, Paik JH, Depinho RA, Kousteni S
Cell Metab. 2010
PubMed ID: 20142102
FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice.
Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC
Cell Metab. 2010
PubMed ID: 20142101
FoxO1 - the key for the pathogenesis and therapy of acne?
Melnik BC
J Dtsch Dermatol Ges. 2010
PubMed ID: 20151947
Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1.
Di Pietro N, Panel V, Hayes S, Bagattin A, Meruvu S, Pandolfi A, Hugendubler L, Fejes-Tóth G, Naray-Fejes-Tóth A, Mueller E
Mol Endocrinol. 2010
PubMed ID: 19965929
Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle.
Ochi E, Hirose T, Hiranuma K, Min SK, Ishii N, Nakazato K
J Appl Physiol. 2010
PubMed ID: 19959771
Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons.
Lin HV, Plum L, Ono H, Gutiérrez-Juárez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D
Diabetes. 2010
PubMed ID: 19933998
Loss of ovarian function in mice results in abrogated skeletal muscle PPARdelta and FoxO1-mediated gene expression.
Rogers NH, Perfield JW, Strissel KJ, Obin MS, Greenberg AS
Biochem Biophys Res Commun. 2010
PubMed ID: 19850007
Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets.
Ideguchi M, Palmer TD, Recht LD, Weimann JM
J Neurosci. 2010
PubMed ID: 20089898
Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.
Chen Q, Ganapathy S, Singh KP, Shankar S, Srivastava RK
PLoS One. 2010
PubMed ID: 21179458
KRIT1 regulates the homeostasis of intracellular reactive oxygen species.
Goitre L, Balzac F, Degani S, Degan P, Marchi S, Pinton P, Retta SF
PLoS One. 2010
PubMed ID: 20668652
Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness.
Lu Y, Dimasi DP, Hysi PG, Hewitt AW, Burdon KP, Toh T, Ruddle JB, Li YJ, Mitchell P, Healey PR, Montgomery GW, Hansell N, Spector TD, Martin NG, Young TL, Hammond CJ, Macgregor S, Craig JE, Mackey DA
PLoS Genet. 2010
PubMed ID: 20485516
Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1.
Reiter CE, Kim JA, Quon MJ
Endocrinology. 2010
PubMed ID: 19887561
Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration.
Cho JE, Fournier M, Da X, Lewis MI
J Appl Physiol. 2010
PubMed ID: 19850732
miR-139 impacts FoxO1 action by decreasing FoxO1 protein in mouse hepatocytes.
Hasseine LK, Hinault C, Lebrun P, Gautier N, Paul-Bellon R, Van Obberghen E
Biochem Biophys Res Commun. 2009
PubMed ID: 19883627
Foxo1 is essential for in vitro vascular formation from embryonic stem cells.
Park SH, Sakamoto H, Tsuji-Tamura K, Furuyama T, Ogawa M
Biochem Biophys Res Commun. 2009
PubMed ID: 19840775
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations.
Li Y, Wang WJ, Cao H, Lu J, Wu C, Hu FY, Guo J, Zhao L, Yang F, Zhang YX, Li W, Zheng GY, Cui H, Chen X, Zhu Z, He H, Dong B, Mo X, Zeng Y, Tian XL
Hum Mol Genet. 2009
PubMed ID: 19793722
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1.
Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens JJ, Ishihara O
Med Mol Morphol. 2009
PubMed ID: 20033367
High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts.
Xia SJ, Holder DD, Pawel BR, Zhang C, Barr FG
Am J Pathol. 2009
PubMed ID: 19893043
Forkhead transcription factor Foxo1 is essential for adipocyte differentiation.
Munekata K, Sakamoto K
In Vitro Cell Dev Biol Anim. 2009
PubMed ID: 19585174
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.
Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA
Cell Stem Cell. 2009
PubMed ID: 19896444
Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin.
Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi J, Liu Z, Cao W
J Biol Chem. 2009
PubMed ID: 19758991
FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol.
Ganjam GK, Dimova EY, Unterman TG, Kietzmann T
J Biol Chem. 2009
PubMed ID: 19740748
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.
Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19850877
Foxo1 integrates insulin signaling with mitochondrial function in the liver.
Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF
Nat Med. 2009
PubMed ID: 19838201
Impaired medulloblastoma cell survival following activation of the FOXO1 transcription factor.
Srivastava VK, Yasruel Z, Nalbantoglu J
Int J Oncol. 2009
PubMed ID: 19787258
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM
Gastroenterology. 2009
PubMed ID: 19686743
T cells require Foxo1 to populate the peripheral lymphoid organs.
Gubbels Bupp MR, Edwards B, Guo C, Wei D, Chen G, Wong B, Masteller E, Peng SL
Eur J Immunol. 2009
PubMed ID: 19658095
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages.
Su D, Coudriet GM, Hyun Kim D, Lu Y, Perdomo G, Qu S, Slusher S, Tse HM, Piganelli J, Giannoukakis N, Zhang J, Henry Dong H
Diabetes. 2009
PubMed ID: 19651810
PAX3-FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis.
Zeng FY, Cui J, Liu L, Chen T
Cancer Lett. 2009
PubMed ID: 19442434
PI3 kinase signals BCR-dependent mature B cell survival.
Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K
Cell. 2009
PubMed ID: 19879843
FoxO transcription factors promote autophagy in cardiomyocytes.
Sengupta A, Molkentin JD, Yutzey KE
J Biol Chem. 2009
PubMed ID: 19696026
FoxM1, a critical regulator of oxidative stress during oncogenesis.
Park HJ, Carr JR, Wang Z, Nogueira V, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P
EMBO J. 2009
PubMed ID: 19696738
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D
Nat Med. 2009
PubMed ID: 19767734
Different roles of Foxo1 and Foxo3 in the control of endothelial cell morphology.
Matsukawa M, Sakamoto H, Kawasuji M, Furuyama T, Ogawa M
Genes Cells. 2009
PubMed ID: 19747349
Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.
Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D
Diabetes. 2009
PubMed ID: 19584310
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, Chiang JY
Biochim Biophys Acta. 2009
PubMed ID: 19463968
Astrocyte elevated gene-1 is a proliferation promoter in breast cancer via suppressing transcriptional factor FOXO1.
Li J, Yang L, Song L, Xiong H, Wang L, Yan X, Yuan J, Wu J, Li M
Oncogene. 2009
PubMed ID: 19633686
Forkhead transcription factor FoxO1 inhibits insulin- and transforming growth factor-beta-stimulated plasminogen activator inhibitor-1 expression.
Jung YA, Lee KM, Kim MK, Jung GS, Seo YJ, Kim HS, Cho HC, Lee KU, Park KG, Lee IK
Biochem Biophys Res Commun. 2009
PubMed ID: 19563779
FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner.
McLoughlin TJ, Smith SM, DeLong AD, Wang H, Unterman TG, Esser KA
Am J Physiol Cell Physiol. 2009
PubMed ID: 19553561
Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells.
Guttilla IK, White BA
J Biol Chem. 2009
PubMed ID: 19574223
Involvement of a forkhead transcription factor, FOXO1A, in UV-induced changes of collagen metabolism.
Tanaka H, Murakami Y, Ishii I, Nakata S
J Investig Dermatol Symp Proc. 2009
PubMed ID: 19675556
FOXO transcription factors enforce cell cycle checkpoints and promote survival of hematopoietic cells after DNA damage.
Lei H, Quelle FW
Mol Cancer Res. 2009
PubMed ID: 19671690
C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.
Li F, Xie P, Fan Y, Zhang H, Zheng L, Gu D, Patterson C, Li H
J Biol Chem. 2009
PubMed ID: 19483080
Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene.
Al-Mubarak B, Soriano FX, Hardingham GE
Channels (Austin). 2009
PubMed ID: 19690465
Differential response of glioma cells to FOXO1-directed therapy.
Lau CJ, Koty Z, Nalbantoglu J
Cancer Res. 2009
PubMed ID: 19549905
A novel role for ac-FOX-O1 in fetal membrane rupture.
Kokkinos MI
Reprod Sci. 2009
PubMed ID: 19535741
Expression and localization of FOXO1 in non-small cell lung cancer.
Maekawa T, Maniwa Y, Doi T, Nishio W, Yoshimura M, Ohbayashi C, Hayashi Y, Okita Y
Oncol Rep. 2009
PubMed ID: 19513505
Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells.
Riol-Blanco L, Delgado-Martín C, Sánchez-Sánchez N, Alonso-C LM, Gutiérrez-López MD, Del Hoyo GM, Navarro J, Sánchez-Madrid F, Cabañas C, Sánchez-Mateos P, Rodríguez-Fernández JL
Nat Immunol. 2009
PubMed ID: 19503105
Overexpression of FOXO1 in skeletal muscle does not alter longevity in mice.
Chiba T, Kamei Y, Shimizu T, Shirasawa T, Katsumata A, Shiraishi L, Sugita S, Ogawa Y, Miura S, Ezaki O
Mech Ageing Dev. 2009
PubMed ID: 19426753
Increased expression of ac-FoxO1 protein in prelabor fetal membranes overlying the cervix: possible role in human fetal membrane rupture.
Lappas M, Riley C, Rice GE, Permezel M
Reprod Sci. 2009
PubMed ID: 19293131
ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status.
Corao DA, Biegel JA, Coffin CM, Barr FG, Wainwright LM, Ernst LM, Choi JK, Zhang PJ, Pawel BR
Pediatr Dev Pathol. 2009
PubMed ID: 18788887
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.
Kim JJ, Li P, Huntley J, Chang JP, Arden KC, Olefsky JM
Diabetes. 2009
PubMed ID: 19289458
MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.
Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W
J Biol Chem. 2009
PubMed ID: 19321440
Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats.
Ropelle ER, Pauli JR, Prada P, Cintra DE, Rocha GZ, Moraes JC, Frederico MJ, da Luz G, Pinho RA, Carvalheira JB, Velloso LA, Saad MA, De Souza CT
J Physiol. 2009
PubMed ID: 19332486
FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes.
Chakrabarti P, Kandror KV
J Biol Chem. 2009
PubMed ID: 19297333
Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.
Sakamaki J, Daitoku H, Yoshimochi K, Miwa M, Fukamizu A
Biochem Biophys Res Commun. 2009
PubMed ID: 19281796
FOXO1 transrepresses peroxisome proliferator-activated receptor gamma transactivation, coordinating an insulin-induced feed-forward response in adipocytes.
Fan W, Imamura T, Sonoda N, Sears DD, Patsouris D, Kim JJ, Olefsky JM
J Biol Chem. 2009
PubMed ID: 19246449
FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.
Shin DJ, Osborne TF
J Biol Chem. 2009
PubMed ID: 19237543
Regulation of neuronal cell death by MST1-FOXO1 signaling.
Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A
J Biol Chem. 2009
PubMed ID: 19221179
Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.
Li X, Rong Y, Zhang M, Wang XL, LeMaire SA, Coselli JS, Zhang Y, Shen YH
Biochem Biophys Res Commun. 2009
PubMed ID: 19254690
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.
Essaghir A, Dif N, Marbehant CY, Coffer PJ, Demoulin JB
J Biol Chem. 2009
PubMed ID: 19244250
The metabolic activator FOXO1 binds hepatitis B virus DNA and activates its transcription.
Shlomai A, Shaul Y
Biochem Biophys Res Commun. 2009
PubMed ID: 19233123
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.
Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C
Cancer Res. 2009
PubMed ID: 19339268
Acetylation of FoxO1 activates Bim expression to induce apoptosis in response to histone deacetylase inhibitor depsipeptide treatment.
Yang Y, Zhao Y, Liao W, Yang J, Wu L, Zheng Z, Yu Y, Zhou W, Li L, Feng J, Wang H, Zhu WG
Neoplasia. 2009
PubMed ID: 19308286
A common variant in DRD3 receptor is associated with autism spectrum disorder.
de Krom M, Staal WG, Ophoff RA, Hendriks J, Buitelaar J, Franke B, de Jonge MV, Bolton P, Collier D, Curran S, van Engeland H, van Ree JM
Biol Psychiatry. 2009
PubMed ID: 19058789
Expression of forkhead transcription factors in human granulosa cells.
Pisarska MD, Kuo FT, Tang D, Zarrini P, Khan S, Ketefian A
Fertil Steril. 2009
PubMed ID: 18692812
An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance.
Ouyang W, Beckett O, Flavell RA, Li MO
Immunity. 2009
PubMed ID: 19285438
Localisation and expression of FoxO1 proteins in human gestational tissues.
Lappas M, Lim R, Riley C, Rice GE, Permezel M
Placenta. 2009
PubMed ID: 19150739
Growth hormone increases mRNA levels of PPARdelta and Foxo1 in skeletal muscle of growth hormone deficient lit/lit mice.
Kim DS, Itoh E, Iida K, Thorner MO
Endocr J. 2009
PubMed ID: 18997443
Acetylation curtails nucleosome binding, not stable nucleosome remodeling, by FoxO1.
Hatta M, Liu F, Cirillo LA
Biochem Biophys Res Commun. 2009
PubMed ID: 19146829
A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose.
Housley MP, Udeshi ND, Rodgers JT, Shabanowitz J, Puigserver P, Hunt DF, Hart GW
J Biol Chem. 2009
PubMed ID: 19103600
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Jung-Hynes B, Nihal M, Zhong W, Ahmad N
J Biol Chem. 2009
PubMed ID: 19075016
FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1.
Yang G, Lim CY, Li C, Xiao X, Radda GK, Li C, Cao X, Han W
J Biol Chem. 2009
PubMed ID: 19049975
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.
Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM
Nat Immunol. 2009
PubMed ID: 19136962
SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma.
Wang F, Tong Q
Mol Biol Cell. 2009
PubMed ID: 19037106
Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.
Long JE, Swan C, Liang WS, Cobos I, Potter GB, Rubenstein JL
J Comp Neurol. 2009
PubMed ID: 19030180
PAX--FKHR fusion genes and AChR-gamma in Chinese patients with rhabdomyosarcoma: diagnosis using formalin-fixed archival tissues.
Chang B, Pang LJ, Qi Y, Liu CX, Cao Y, Li HA, Hu WH, Jiang JF, Zhang WJ, Li F
Int J Surg Pathol. 2009
PubMed ID: 18988640
Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.
Cabodi S, Morello V, Masi A, Cicchi R, Broggio C, Distefano P, Brunelli E, Silengo L, Pavone F, Arcangeli A, Turco E, Tarone G, Moro L, Defilippi P
J Cell Physiol. 2009
PubMed ID: 18844239
Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.
Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X
Biol Psychiatry. 2009
PubMed ID: 18823877
Foxo1 increases pro-inflammatory gene expression by inducing C/EBPbeta in TNF-alpha-treated adipocytes.
Ito Y, Daitoku H, Fukamizu A
Biochem Biophys Res Commun. 2009
PubMed ID: 19026986
Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.
Choi J, Oh S, Lee D, Oh HJ, Park JY, Lee SB, Lim DS
PLoS One. 2009
PubMed ID: 19956688
HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes.
Lynch VJ, Brayer K, Gellersen B, Wagner GP
PLoS One. 2009
PubMed ID: 19727442
COP1 functions as a FoxO1 ubiquitin E3 ligase to regulate FoxO1-mediated gene expression.
Kato S, Ding J, Pisck E, Jhala US, Du K
J Biol Chem. 2008
PubMed ID: 18815134
Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen.
Behl Y, Siqueira M, Ortiz J, Li J, Desta T, Faibish D, Graves DT
J Immunol. 2008
PubMed ID: 19050291
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation.
Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC
Nat Immunol. 2008
PubMed ID: 18978794
Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors.
Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, Steinbrenner H
Hepatology. 2008
PubMed ID: 18972406
A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.
Hirota K, Sakamaki J, Ishida J, Shimamoto Y, Nishihara S, Kodama N, Ohta K, Yamamoto M, Tanimoto K, Fukamizu A
J Biol Chem. 2008
PubMed ID: 18805788
Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway.
Liu HY, Wen GB, Han J, Hong T, Zhuo D, Liu Z, Cao W
J Biol Chem. 2008
PubMed ID: 18786922
[Skeletal muscle function and FOXO]
Kamei Y, Ogawa Y
Seikagaku. 2008
PubMed ID: 19086408
Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells.
Abid MR, Nadeau RJ, Spokes KC, Minami T, Li D, Shih SC, Aird WC
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18787186
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR
Diabetes. 2008
PubMed ID: 18728232
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
Mol Cell. 2008
PubMed ID: 18951090
Dehydroepiandrosterone stimulates phosphorylation of FoxO1 in vascular endothelial cells via phosphatidylinositol 3-kinase- and protein kinase A-dependent signaling pathways to regulate ET-1 synthesis and secretion.
Chen H, Lin AS, Li Y, Reiter CE, Ver MR, Quon MJ
J Biol Chem. 2008
PubMed ID: 18718910
TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling.
Moylan JS, Smith JD, Chambers MA, McLoughlin TJ, Reid MB
Am J Physiol Cell Physiol. 2008
PubMed ID: 18701653
The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.
Waddell DS, Baehr LM, van den Brandt J, Johnsen SA, Reichardt HM, Furlow JD, Bodine SC
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18612045
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.
Brent MM, Anand R, Marmorstein R
Structure. 2008
PubMed ID: 18786403
FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase.
Fabre S, Carrette F, Chen J, Lang V, Semichon M, Denoyelle C, Lazar V, Cagnard N, Dubart-Kupperschmitt A, Mangeney M, Fruman DA, Bismuth G
J Immunol. 2008
PubMed ID: 18713968
Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function.
Lieber CS, Leo MA, Wang X, Decarli LM
Biochem Biophys Res Commun. 2008
PubMed ID: 18555008
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor.
Liu P, Kao TP, Huang H
Oncogene. 2008
PubMed ID: 18408765
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, Potente M, Daly C, Dimmeler S, Dejana E
Nat Cell Biol. 2008
PubMed ID: 18604199
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF
Cell Metab. 2008
PubMed ID: 18590693
O-GlcNAc regulates FoxO activation in response to glucose.
Housley MP, Rodgers JT, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW
J Biol Chem. 2008
PubMed ID: 18420577
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.
Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, Meseck M, Dong HH
J Clin Invest. 2008
PubMed ID: 18497885
Overindulgence and metabolic syndrome: is FoxO1 a missing link?
Sparks JD, Sparks CE
J Clin Invest. 2008
PubMed ID: 18497882
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development.
Amin RH, Schlissel MS
Nat Immunol. 2008
PubMed ID: 18469817
A comprehensive analysis of transcript signatures of the phosphatidylinositol-3 kinase/protein kinase B signal-transduction pathway in prostate cancer.
Hellwinkel OJ, Rogmann JP, Asong LE, Luebke AM, Eichelberg C, Ahyai S, Isbarn H, Graefen M, Huland H, Schlomm T
BJU Int. 2008
PubMed ID: 18336616
CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress.
Nahlé Z, Hsieh M, Pietka T, Coburn CT, Grimaldi PA, Zhang MQ, Das D, Abumrad NA
J Biol Chem. 2008
PubMed ID: 18308721
Phosphorylation regulates transcriptional activity of PAX3/FKHR and reveals novel therapeutic possibilities.
Amstutz R, Wachtel M, Troxler H, Kleinert P, Ebauer M, Haneke T, Oehler-Jänne C, Fabbro D, Niggli FK, Schäfer BW
Cancer Res. 2008
PubMed ID: 18483260
Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.
Fritzius T, Moelling K
EMBO J. 2008
PubMed ID: 18388859
Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells.
Feutz AC, Barrandon Y, Monard D
J Cell Sci. 2008
PubMed ID: 18398001
Increased expression and activity of the transcription factor FOXO1 in nonalcoholic steatohepatitis.
Valenti L, Rametta R, Dongiovanni P, Maggioni M, Fracanzani AL, Zappa M, Lattuada E, Roviaro G, Fargion S
Diabetes. 2008
PubMed ID: 18316359
Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.
Kamei Y, Miura S, Suganami T, Akaike F, Kanai S, Sugita S, Katsumata A, Aburatani H, Unterman TG, Ezaki O, Ogawa Y
Endocrinology. 2008
PubMed ID: 18202130
PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.
Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, Brüning JC
Cell Metab. 2008
PubMed ID: 18396135
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump.
Pardo PS, Lopez MA, Boriek AM
Am J Physiol Cell Physiol. 2008
PubMed ID: 18272820
The regulation and function of the forkhead transcription factor, Forkhead box O1, is dependent on the progesterone receptor in endometrial carcinoma.
Ward EC, Hoekstra AV, Blok LJ, Hanifi-Moghaddam P, Lurain JR, Singh DK, Buttin BM, Schink JC, Kim JJ
Endocrinology. 2008
PubMed ID: 18096667
Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors.
Evans-Anderson HJ, Alfieri CM, Yutzey KE
Circ Res. 2008
PubMed ID: 18218983
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
Yuan Z, Becker EB, Merlo P, Yamada T, DiBacco S, Konishi Y, Schaefer EM, Bonni A
Science. 2008
PubMed ID: 18356527
PP2A regulates the pro-apoptotic activity of FOXO1.
Yan L, Lavin VA, Moser LR, Cui Q, Kanies C, Yang E
J Biol Chem. 2008
PubMed ID: 18211894
O-glycosylation of FoxO1 increases its transcriptional activity towards the glucose 6-phosphatase gene.
Kuo M, Zilberfarb V, Gangneux N, Christeff N, Issad T
FEBS Lett. 2008
PubMed ID: 18280254
Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation.
Mehra S, de la Roza G, Tull J, Shrimpton A, Valente A, Zhang S
Diagn Mol Pathol. 2008
PubMed ID: 18303411
Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure.
Nakae J, Cao Y, Oki M, Orba Y, Sawa H, Kiyonari H, Iskandar K, Suga K, Lombes M, Hayashi Y
Diabetes. 2008
PubMed ID: 18162510
Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components.
Wu AL, Kim JH, Zhang C, Unterman TG, Chen J
Endocrinology. 2008
PubMed ID: 18079193
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A.
Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA
Hum Mol Genet. 2008
PubMed ID: 17993506
[The effect of calorie restriction on the expression of liver's gluconeogenesis genes of rats fed a high fat diet]
Luo MJ, Chen LL, Zheng J, Zeng TS, Deng XL
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 18304430
Forkhead transcription factors coordinate expression of myocardial KATP channel subunits and energy metabolism.
Philip-Couderc P, Tavares NI, Roatti A, Lerch R, Montessuit C, Baertschi AJ
Circ Res. 2008
PubMed ID: 18202312
The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction.
Kim DH, Kim JY, Yu BP, Chung HY
Biogerontology. 2008
PubMed ID: 17972158
Nuclear exclusion of forkhead box O and Elk1 and activation of nuclear factor-kappaB are required for C2C12-RasV12C40 myoblast differentiation.
De Alvaro C, Nieto-Vazquez I, Rojas JM, Lorenzo M
Endocrinology. 2008
PubMed ID: 17962350
Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
Kikuchi K, Tsuchiya K, Otabe O, Gotoh T, Tamura S, Katsumi Y, Yagyu S, Tsubai-Shimizu S, Miyachi M, Iehara T, Hosoi H
Biochem Biophys Res Commun. 2008
PubMed ID: 18022385
Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor.
Walter PL, Steinbrenner H, Barthel A, Klotz LO
Biochem Biophys Res Commun. 2008
PubMed ID: 17986386
The FoxO transcription factors and metabolic regulation.
Nakae J, Oki M, Cao Y
FEBS Lett. 2008
PubMed ID: 18022395
Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells.
Goto T, Takano M, Albergaria A, Briese J, Pomeranz KM, Cloke B, Fusi L, Feroze-Zaidi F, Maywald N, Sajin M, Dina RE, Ishihara O, Takeda S, Lam EW, Bamberger AM, Ghaem-Maghami S, Brosens JJ
Oncogene. 2008
PubMed ID: 17599040
A combination of genomic approaches reveals the role of FOXO1a in regulating an oxidative stress response pathway.
de Candia P, Blekhman R, Chabot AE, Oshlack A, Gilad Y
PLoS ONE. 2008
PubMed ID: 18301748
How the Smads regulate transcription.
Ross S, Hill CS
Int J Biochem Cell Biol. 2008
PubMed ID: 18061509
Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
Millien G, Beane J, Lenburg M, Tsao PN, Lu J, Spira A, Ramirez MI
Gene Expr Patterns. 2008
PubMed ID: 18023262
Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells.
Dixit M, Bess E, Fisslthaler B, Härtel FV, Noll T, Busse R, Fleming I
Cardiovasc Res. 2008
PubMed ID: 18006475
Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
Yasui A, Nishizawa H, Okuno Y, Morita K, Kobayashi H, Kawai K, Matsuda M, Kishida K, Kihara S, Kamei Y, Ogawa Y, Funahashi T, Shimomura I
Biochem Biophys Res Commun. 2007
PubMed ID: 17950246
Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice.
Liu CM, Yang Z, Liu CW, Wang R, Tien P, Dale R, Sun LQ
Cancer Gene Ther. 2007
PubMed ID: 17885675
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.
McClung JM, Kavazis AN, Whidden MA, DeRuisseau KC, Falk DJ, Criswell DS, Powers SK
J Physiol. 2007
PubMed ID: 17916612
PAX3-FOXO1 controls expression of the p57Kip2 cell-cycle regulator through degradation of EGR1.
Roeb W, Boyer A, Cavenee WK, Arden KC
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17986608
Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR.
Ebauer M, Wachtel M, Niggli FK, Schäfer BW
Oncogene. 2007
PubMed ID: 17525748
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
Bouchard C, Lee S, Paulus-Hock V, Loddenkemper C, Eilers M, Schmitt CA
Genes Dev. 2007
PubMed ID: 17974917
Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients.
Kuo CC, Lin SC
Mol Med. 2007
PubMed ID: 17873969
Transcriptional cross talk between the forkhead transcription factor forkhead box O1A and the progesterone receptor coordinates cell cycle regulation and differentiation in human endometrial stromal cells.
Takano M, Lu Z, Goto T, Fusi L, Higham J, Francis J, Withey A, Hardt J, Cloke B, Stavropoulou AV, Ishihara O, Lam EW, Unterman TG, Brosens JJ, Kim JJ
Mol Endocrinol. 2007
PubMed ID: 17609436
Forkhead protein FKHR and its phosphorylated form p-FKHR in human prostate cancer.
Li R, Erdamar S, Dai H, Wheeler TM, Frolov A, Scardino PT, Thompson TC, Ayala GE
Hum Pathol. 2007
PubMed ID: 17597184
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver.
Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D
Cell Metab. 2007
PubMed ID: 17767907
A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.
Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D
J Clin Invest. 2007
PubMed ID: 17717603
A SNP haplotype of the forkhead transcription factor FOXO1A gene may have a protective effect against type 2 diabetes in German Caucasians.
Böttcher Y, Tönjes A, Enigk B, Scholz GH, Blüher M, Stumvoll M, Kovacs P
Diabetes Metab. 2007
PubMed ID: 17555999
Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.
Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A
EMBO J. 2007
PubMed ID: 17627282
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation.
Jing E, Gesta S, Kahn CR
Cell Metab. 2007
PubMed ID: 17681146
Constitutive phosphorylation of the FOXO1A transcription factor as a prognostic variable in gastric cancer.
Kim JH, Kim MK, Lee HE, Cho SJ, Cho YJ, Lee BL, Lee HS, Nam SY, Lee JS, Kim WH
Mod Pathol. 2007
PubMed ID: 17491598
Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Doucet M, Russell AP, Léger B, Debigaré R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
Am J Respir Crit Care Med. 2007
PubMed ID: 17478621
The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
Linardic CM, Naini S, Herndon JE, Kesserwan C, Qualman SJ, Counter CM
Cancer Res. 2007
PubMed ID: 17638879
The regulation of adiponectin receptors expression by acute exercise in mice.
Huang H, Iida KT, Sone H, Ajisaka R
Exp Clin Endocrinol Diabetes. 2007
PubMed ID: 17647137
The oncogenic transcription factor PAX3-FKHR can convert fibroblasts into contractile myotubes.
Scuoppo C, Riess I, Schmitt-Ney M, Allegra P, Forni PE, Bersani F, Taulli R, Accornero P, Crepaldi T, Ponzetto C
Exp Cell Res. 2007
PubMed ID: 17490646
Role of FoxO1 in FFA-induced oxidative stress in adipocytes.
Subauste AR, Burant CF
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17374693
Constitutively active FOXO1a and a DNA-binding domain mutant exhibit distinct co-regulatory functions to enhance progesterone receptor A activity.
Rudd MD, Gonzalez-Robayna I, Hernandez-Gonzalez I, Weigel NL, Bingman WE, Richards JS
J Mol Endocrinol. 2007
PubMed ID: 17556536
A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior.
Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, Tschöp MH, Treier M
Cell Metab. 2007
PubMed ID: 17550780
Regulation of scavenger receptor class BI gene expression by angiotensin II in vascular endothelial cells.
Yu X, Murao K, Imachi H, Cao WM, Li J, Matsumoto K, Nishiuchi T, Ahmed RA, Wong NC, Kosaka H, Unterman TG, Ishida T
Hypertension. 2007
PubMed ID: 17404186
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes.
Naïmi M, Gautier N, Chaussade C, Valverde AM, Accili D, Van Obberghen E
Endocrinology. 2007
PubMed ID: 17303659
E2F-1 regulates expression of FOXO1 and FOXO3a.
Nowak K, Killmer K, Gessner C, Lutz W
Biochim Biophys Acta. 2007
PubMed ID: 17482685
The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells.
Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA
Gastroenterology. 2007
PubMed ID: 17408630
Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.
Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, Fukamizu A, Kato S, Takayanagi R, Nawata H
J Biol Chem. 2007
PubMed ID: 17202144
Identification of a new class of PAX3-FKHR target promoters: a role of the Pax3 paired box DNA binding domain.
Zhang L, Wang C
Oncogene. 2007
PubMed ID: 16964289
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA
Nat Med. 2007
PubMed ID: 17322895
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1.
Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, Mukai H, Iwashita S, Kako K, Kishi T, Kasuya Y, Fukamizu A
Cell Signal. 2007
PubMed ID: 17113751
Regulation of Foxo-1 and the angiopoietin-2/Tie2 system by shear stress.
Chlench S, Mecha Disassa N, Hohberg M, Hoffmann C, Pohlkamp T, Beyer G, Bongrazio M, Da Silva-Azevedo L, Baum O, Pries AR, Zakrzewicz A
FEBS Lett. 2007
PubMed ID: 17258205
Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1.
Fisslthaler B, Fleming I, Keserü B, Walsh K, Busse R
Circ Res. 2007
PubMed ID: 17218607
FOXO genes act in vivo as tumor suppressors.

Cancer Biol Ther. 2007
PubMed ID: 17585407
[Expression of fusion gene PAX3/PAX7-FKHR and chromosomal aberration in rhabdomyosarcoma]
Gao H, Ou YL, Zhang KR, Zhang ZB, Wang WL
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
PubMed ID: 17285543
Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin.
Anton S, Melville L, Rena G
Cell Signal. 2007
PubMed ID: 16950602
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG
Cell. 2007
PubMed ID: 17254970
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA
Cell. 2007
PubMed ID: 17254969
B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Bruton's tyrosine kinase.
Hinman RM, Bushanam JN, Nichols WA, Satterthwaite AB
J Immunol. 2007
PubMed ID: 17202334
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.
Nechamen CA, Thomas RM, Dias JA
Mol Cell Endocrinol. 2007
PubMed ID: 17030088
Pax3-fkhr and pax7-fkhr fusion genes impact outcome of alveolar rhabdomyosarcoma in children.
Kazanowska B, Reich A, Stegmaier S, Békássy AN, Leuschner I, Chybicka A, Koscielniak E
Fetal Pediatr Pathol. 2007
PubMed ID: 17613043
Aberrant over-expression of a forkhead family member, FOXO1A, in a brain tumor cell line.
Dallas PB, Egli S, Terry PA, Kees UR
BMC Cancer. 2007
PubMed ID: 17442120
Effects of caloric restriction and growth hormone resistance on insulin-related intermediates in the skeletal muscle.
Al-Regaiey KA, Masternak MM, Bonkowski MS, Panici JA, Kopchick JJ, Bartke A
J Gerontol A Biol Sci Med Sci. 2007
PubMed ID: 17301033
Bidirectional regulation of upstream IGF-I/insulin receptor signaling and downstream FOXO1 in cardiomyocytes.
Liu TJ, Lai HC, Ting CT, Wang PH
J Endocrinol. 2007
PubMed ID: 17210752
SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.
Qiao L, Shao J
J Biol Chem. 2006
PubMed ID: 17090532
Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism.
Qu S, Altomonte J, Perdomo G, He J, Fan Y, Kamagate A, Meseck M, Dong HH
Endocrinology. 2006
PubMed ID: 16997836
Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex.
Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM
Genes Dev. 2006
PubMed ID: 17050673
Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure.
Watkins WJ, Umbers AJ, Woad KJ, Harris SE, Winship IM, Gersak K, Shelling AN
Fertil Steril. 2006
PubMed ID: 16979636
Epstein-Barr virus represses the FoxO1 transcription factor through latent membrane protein 1 and latent membrane protein 2A.
Shore AM, White PC, Hui RC, Essafi A, Lam EW, Rowe M, Brennan P
J Virol. 2006
PubMed ID: 16943287
Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
Léger B, Cartoni R, Praz M, Lamon S, Dériaz O, Crettenand A, Gobelet C, Rohmer P, Konzelmann M, Luthi F, Russell AP
J Physiol. 2006
PubMed ID: 16916907
Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism.
McFarlane C, Plummer E, Thomas M, Hennebry A, Ashby M, Ling N, Smith H, Sharma M, Kambadur R
J Cell Physiol. 2006
PubMed ID: 16883577
Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
Charvet C, Canonigo AJ, Bécart S, Maurer U, Miletic AV, Swat W, Deckert M, Altman A
J Immunol. 2006
PubMed ID: 17015685
Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions.
Walter PL, Kampkötter A, Eckers A, Barthel A, Schmoll D, Sies H, Klotz LO
Arch Biochem Biophys. 2006
PubMed ID: 16973122
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
Huang H, Regan KM, Lou Z, Chen J, Tindall DJ
Science. 2006
PubMed ID: 17038621
Transgenic mice expressing PAX3-FKHR have multiple defects in muscle development, including ectopic skeletal myogenesis in the developing neural tube.
Finckenstein FG, Davicioni E, Osborn KG, Cavenee WK, Arden KC, Anderson MJ
Transgenic Res. 2006
PubMed ID: 16952014
Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization.
Kajihara T, Jones M, Fusi L, Takano M, Feroze-Zaidi F, Pirianov G, Mehmet H, Ishihara O, Higham JM, Lam EW, Brosens JJ
Mol Endocrinol. 2006
PubMed ID: 16709600
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
Li T, Kong X, Owsley E, Ellis E, Strom S, Chiang JY
J Biol Chem. 2006
PubMed ID: 16885156
Transcriptional genomics associates FOX transcription factors with human heart failure.
Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP
Circulation. 2006
PubMed ID: 16952980
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.
Ni YG, Berenji K, Wang N, Oh M, Sachan N, Dey A, Cheng J, Lu G, Morris DJ, Castrillon DH, Gerard RD, Rothermel BA, Hill JA
Circulation. 2006
PubMed ID: 16952979
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.
Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, Hayashi Y
J Clin Invest. 2006
PubMed ID: 16917544
Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.
Matsumoto M, Han S, Kitamura T, Accili D
J Clin Invest. 2006
PubMed ID: 16906224
Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice.
Aoyama H, Daitoku H, Fukamizu A
Int J Mol Med. 2006
PubMed ID: 16865227
FOXO1A differentially regulates genes of decidualization.
Buzzio OL, Lu Z, Miller CD, Unterman TG, Kim JJ
Endocrinology. 2006
PubMed ID: 16690806
FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity.
Armoni M, Harel C, Karni S, Chen H, Bar-Yoseph F, Ver MR, Quon MJ, Karnieli E
J Biol Chem. 2006
PubMed ID: 16670091
FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer.
Dong XY, Chen C, Sun X, Guo P, Vessella RL, Wang RX, Chung LW, Zhou W, Dong JT
Cancer Res. 2006
PubMed ID: 16849544
C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1.
Fosbrink M, Niculescu F, Rus V, Shin ML, Rus H
J Biol Chem. 2006
PubMed ID: 16670089
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.
Samuel VT, Choi CS, Phillips TG, Romanelli AJ, Geisler JG, Bhanot S, McKay R, Monia B, Shutter JR, Lindberg RA, Shulman GI, Veniant MM
Diabetes. 2006
PubMed ID: 16804074
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis.
Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, Kim KS, Kim SW, Kim HS, Park JY, Kim YB, Lee KU
Nat Neurosci. 2006
PubMed ID: 16783365
Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins.
Mounier C, Dumas V, Posner BI
Endocrinology. 2006
PubMed ID: 16455781
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.
Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich KA, Sajan MP, Farese RV, Stolz DB, Tso P, Koo SH, Montminy M, Unterman TG
J Biol Chem. 2006
PubMed ID: 16492665
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Polymorphisms in FOXO gene family and association analysis with BMI.
Kim JR, Jung HS, Bae SW, Kim JH, Park BL, Choi YH, Cho HY, Cheong HS, Shin HD
Obesity (Silver Spring). 2006
PubMed ID: 16571842
Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.
Wijchers PJ, Hoekman MF, Burbach JP, Smidt MP
Brain Res. 2006
PubMed ID: 16376864
Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain.
Hoekman MF, Jacobs FM, Smidt MP, Burbach JP
Gene Expr Patterns. 2006
PubMed ID: 16326148
Progestins regulate the expression and activity of the forkhead transcription factor FOXO1 in differentiating human endometrium.
Labied S, Kajihara T, Madureira PA, Fusi L, Jones MC, Higham JM, Varshochi R, Francis JM, Zoumpoulidou G, Essafi A, Fernandez de Mattos S, Lam EW, Brosens JJ
Mol Endocrinol. 2006
PubMed ID: 16123151
Smad transcription factors.
Massagué J, Seoane J, Wotton D
Genes Dev. 2005
PubMed ID: 16322555
Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.
Chen B, Schaevitz LR, McConnell SK
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16284245
Practical vessel imaging by computed tomography in live transgenic mouse models for human tumors.
Kindlmann GL, Weinstein DM, Jones GM, Johnson CR, Capecchi MR, Keller C
Mol Imaging. 2005
PubMed ID: 16285903
The cooperative transforming effects of PAX3-FKHR and IGF-II on mouse myoblasts.
Wang W, Slevin M, Kumar S, Kumar P
Int J Oncol. 2005
PubMed ID: 16142327
Regulation of the proapoptotic factor FOXO1 (FKHR) in cardiomyocytes by growth factors and alpha1-adrenergic agonists.
Morris JB, Kenney B, Huynh H, Woodcock EA
Endocrinology. 2005
PubMed ID: 16020479
Role of FOXO1A in the regulation of insulin-like growth factor-binding protein-1 in human endometrial cells: interaction with progesterone receptor.
Kim JJ, Buzzio OL, Li S, Lu Z
Biol Reprod. 2005
PubMed ID: 15987820
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Götz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M
Nat Neurosci. 2005
PubMed ID: 16116448
FoxO1a-cyclic GMP-dependent kinase I interactions orchestrate myoblast fusion.
Bois PR, Brochard VF, Salin-Cantegrel AV, Cleveland JL, Grosveld GC
Mol Cell Biol. 2005
PubMed ID: 16107711
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.
Potente M, Urbich C, Sasaki K, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S
J Clin Invest. 2005
PubMed ID: 16100571
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
Perrot V, Rechler MM
Mol Endocrinol. 2005
PubMed ID: 15890677
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.
Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16076959
Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells.
Schwab TS, Madison BB, Grauman AR, Feldman EL
Apoptosis. 2005
PubMed ID: 16133873
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.
Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC
Genes Dev. 2005
PubMed ID: 16027169
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes.
Frescas D, Valenti L, Accili D
J Biol Chem. 2005
PubMed ID: 15788402
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
Essers MA, de Vries-Smits LM, Barker N, Polderman PE, Burgering BM, Korswagen HC
Science. 2005
PubMed ID: 15905404
Co-expression of alternatively spliced forms of PAX3, PAX7, PAX3-FKHR and PAX7-FKHR with distinct DNA binding and transactivation properties in rhabdomyosarcoma.
Du S, Lawrence EJ, Strzelecki D, Rajput P, Xia SJ, Gottesman DM, Barr FG
Int J Cancer. 2005
PubMed ID: 15688409
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity.
Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW
J Cell Biol. 2005
PubMed ID: 15837797
FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms.
Bastie CC, Nahlé Z, McLoughlin T, Esser K, Zhang W, Unterman T, Abumrad NA
J Biol Chem. 2005
PubMed ID: 15691844
Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control.
Fabre S, Lang V, Harriague J, Jobart A, Unterman TG, Trautmann A, Bismuth G
J Immunol. 2005
PubMed ID: 15778376
FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis.
Alikhani M, Alikhani Z, Graves DT
J Biol Chem. 2005
PubMed ID: 15632117
Induction of cyclin D2 in rat granulosa cells requires FSH-dependent relief from FOXO1 repression coupled with positive signals from Smad.
Park Y, Maizels ET, Feiger ZJ, Alam H, Peters CA, Woodruff TK, Unterman TG, Lee EJ, Jameson JL, Hunzicker-Dunn M
J Biol Chem. 2005
PubMed ID: 15613482
Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR.
Begum S, Emami N, Emani N, Cheung A, Wilkins O, Der S, Hamel PA
Oncogene. 2005
PubMed ID: 15688035
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
Yang Y, Hou H, Haller EM, Nicosia SV, Bai W
EMBO J. 2005
PubMed ID: 15692560
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.
Di-Poï N, Ng CY, Tan NS, Yang Z, Hemmings BA, Desvergne B, Michalik L, Wahli W
Mol Cell Biol. 2005
PubMed ID: 15713628
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation.
Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15668399
Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway.
Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD, Glass DJ
J Biol Chem. 2005
PubMed ID: 15550386
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.
Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M
Nature. 2004
PubMed ID: 15616563
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Inactivation of Rho/ROCK signaling is crucial for the nuclear accumulation of FKHR and myoblast fusion.
Nishiyama T, Kii I, Kudo A
J Biol Chem. 2004
PubMed ID: 15322110
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.
Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N
Exp Gerontol. 2004
PubMed ID: 15582274
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR
Genes Dev. 2004
PubMed ID: 15489287
Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.
Valverde AM, Mur C, Brownlee M, Benito M
Mol Biol Cell. 2004
PubMed ID: 15356271
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control.
Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O
J Biol Chem. 2004
PubMed ID: 15272020
Cellular models for the analysis of signaling by protein kinase B and the forkhead transcription factor FKHR (Foxo1a).
Orth HM, Krüger KD, Schmoll D, Grempler R, Scherbaum WA, Joost HG, Bornstein SR, Barthel A
Regul Pept. 2004
PubMed ID: 15256269
Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins.
Aoki M, Jiang H, Vogt PK
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15342912
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
Kodama S, Koike C, Negishi M, Yamamoto Y
Mol Cell Biol. 2004
PubMed ID: 15340055
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice.
Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, Ikeda K, Motoyama N, Mori N
J Biol Chem. 2004
PubMed ID: 15184386
Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression.
Tomescu O, Xia SJ, Strezlecki D, Bennicelli JL, Ginsberg J, Pawel B, Barr FG
Lab Invest. 2004
PubMed ID: 15184910
Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.
Yusuf I, Zhu X, Kharas MG, Chen J, Fruman DA
Blood. 2004
PubMed ID: 15069012
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T
J Biol Chem. 2004
PubMed ID: 15123605
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, Fukamizu A
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15220471
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.
Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ
Mol Cell. 2004
PubMed ID: 15125842
Solid alveolar rhabdomyosarcoma originating from the urinary bladder in an adult. Diagnostic value of molecular genetics.
Lambert I, Debiec-Rychter M, Dubin M, Sciot R
Histopathology. 2004
PubMed ID: 15140004
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.
Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL
Cell. 2004
PubMed ID: 15109499
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Seoane J, Le HV, Shen L, Anderson SA, Massagué J
Cell. 2004
PubMed ID: 15084259
Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells.
Huang H, Muddiman DC, Tindall DJ
J Biol Chem. 2004
PubMed ID: 14726521
The DNA sequence and analysis of human chromosome 13.
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Nature. 2004
PubMed ID: 15057823
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors.
Kwon HS, Huang B, Unterman TG, Harris RA
Diabetes. 2004
PubMed ID: 15047604
Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms.
Zhao X, Gan L, Pan H, Kan D, Majeski M, Adam SA, Unterman TG
Biochem J. 2004
PubMed ID: 14664696
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.
Hosaka T, Biggs WH, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14978268
SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.
Wang X, Chen L, Maures TJ, Herrington J, Carter-Su C
J Biol Chem. 2004
PubMed ID: 14565960
Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion.
Tsai WC, Bhattacharyya N, Han LY, Hanover JA, Rechler MM
Endocrinology. 2003
PubMed ID: 14500580
Constitutive phosphorylation of FKHR transcription factor as a prognostic variable in acute myeloid leukemia.
Cheong JW, Eom JI, Maeng HY, Lee ST, Hahn JS, Ko YW, Min YH
Leuk Res. 2003
PubMed ID: 12921955
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways.
Dowell P, Otto TC, Adi S, Lane MD
J Biol Chem. 2003
PubMed ID: 12966085
Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1.
Andreucci M, Michael A, Kramers C, Park KM, Chen A, Matthaeus T, Alessandrini A, Haq S, Force T, Bonventre JV
Kidney Int. 2003
PubMed ID: 12969136
Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1.
Crossley LJ
J Leukoc Biol. 2003
PubMed ID: 12960271
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice.
Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12783775
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation.
Matsuzaki H, Daitoku H, Hatta M, Tanaka K, Fukamizu A
Proc Natl Acad Sci U S A. 2003
PubMed ID: 13679577
FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.
Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP
J Biol Chem. 2003
PubMed ID: 12857750
Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells.
Machida S, Spangenburg EE, Booth FW
J Cell Physiol. 2003
PubMed ID: 12891709
Characterization of insulin inhibition of transactivation by a C-terminal fragment of the forkhead transcription factor Foxo1 in rat hepatoma cells.
Perrot V, Rechler MM
J Biol Chem. 2003
PubMed ID: 12724332
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction.
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM
Nature. 2003
PubMed ID: 12754525
Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor.
Hirota K, Daitoku H, Matsuzaki H, Araya N, Yamagata K, Asada S, Sugaya T, Fukamizu A
J Biol Chem. 2003
PubMed ID: 12519792
FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts.
Bois PR, Grosveld GC
EMBO J. 2003
PubMed ID: 12606579
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.
Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A
Diabetes. 2003
PubMed ID: 12606503
Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells.
Mazumdar A, Kumar R
FEBS Lett. 2003
PubMed ID: 12560069
The forkhead transcription factor Foxo1 regulates adipocyte differentiation.
Nakae J, Kitamura T, Kitamura Y, Biggs WH, Arden KC, Accili D
Dev Cell. 2003
PubMed ID: 12530968
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells.
Kim JJ, Taylor HS, Akbas GE, Foucher I, Trembleau A, Jaffe RC, Fazleabas AT, Unterman TG
Biol Reprod. 2003
PubMed ID: 12493691
AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.
Li P, Lee H, Guo S, Unterman TG, Jenster G, Bai W
Mol Cell Biol. 2003
PubMed ID: 12482965
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S, Unterman TG
J Biol Chem. 2002
PubMed ID: 12228231
Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.
Lagutina I, Conway SJ, Sublett J, Grosveld GC
Mol Cell Biol. 2002
PubMed ID: 12242297
Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors.
Foucher I, Volovitch M, Frain M, Kim JJ, Souberbielle JC, Gan L, Unterman TG, Prochiantz A, Trembleau A
Development. 2002
PubMed ID: 12163409
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.
Ramaswamy S, Nakamura N, Sansal I, Bergeron L, Sellers WR
Cancer Cell. 2002
PubMed ID: 12150827
Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT/enhancer-binding protein beta in differentiating human endometrial stromal cells.
Christian M, Zhang X, Schneider-Merck T, Unterman TG, Gellersen B, White JO, Brosens JJ
J Biol Chem. 2002
PubMed ID: 11893744
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM, Bridge JA, Crist WM, Triche TJ, Barr FG
J Clin Oncol. 2002
PubMed ID: 12039929
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, Williams MR, Cohen P
EMBO J. 2002
PubMed ID: 11980723
Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins.
Richards JS, Sharma SC, Falender AE, Lo YH
Mol Endocrinol. 2002
PubMed ID: 11875118
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression.
Nakae J, Kitamura T, Silver DL, Accili D
J Clin Invest. 2001
PubMed ID: 11696581
Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression.
Patel S, Lochhead PA, Rena G, Sutherland C
Biochem J. 2001
PubMed ID: 11672436
Transcriptional regulation of IGF-I receptor gene expression by the PAX3-FKHR oncoprotein.
Ayalon D, Glaser T, Werner H
Growth Horm IGF Res. 2001
PubMed ID: 11735247
Ligand-dependent interaction of estrogen receptor-alpha with members of the forkhead transcription factor family.
Schuur ER, Loktev AV, Sharma M, Sun Z, Roth RA, Weigel RJ
J Biol Chem. 2001
PubMed ID: 11435445
Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions.
Zhao HH, Herrera RE, Coronado-Heinsohn E, Yang MC, Ludes-Meyers JH, Seybold-Tilson KJ, Nawaz Z, Yee D, Barr FG, Diab SG, Brown PH, Fuqua SA, Osborne CK
J Biol Chem. 2001
PubMed ID: 11353774
Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.
Biggs WH, Cavenee WK, Arden KC
Mamm Genome. 2001
PubMed ID: 11353388
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
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Biochem J. 2001
PubMed ID: 11311120
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
Rena G, Prescott AR, Guo S, Cohen P, Unterman TG
Biochem J. 2001
PubMed ID: 11237865
Embryonic expression of the tumor-associated PAX3-FKHR fusion protein interferes with the developmental functions of Pax3.
Anderson MJ, Shelton GD, Cavenee WK, Arden KC
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11171995
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.
Schmoll D, Walker KS, Alessi DR, Grempler R, Burchell A, Guo S, Walther R, Unterman TG
J Biol Chem. 2000
PubMed ID: 10960473
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
Jackson JG, Kreisberg JI, Koterba AP, Yee D, Brattain MG
Oncogene. 2000
PubMed ID: 11030146
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells.
Nasrin N, Ogg S, Cahill CM, Biggs W, Nui S, Dore J, Calvo D, Shi Y, Ruvkun G, Alexander-Bridges MC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10973497
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.
Furuyama T, Nakazawa T, Nakano I, Mori N
Biochem J. 2000
PubMed ID: 10880363
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.
Margue CM, Bernasconi M, Barr FG, Schäfer BW
Oncogene. 2000
PubMed ID: 10871843
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.
Medema RH, Kops GJ, Bos JL, Burgering BM
Nature. 2000
PubMed ID: 10783894
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
Biggs WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10377430
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Rena G, Guo S, Cichy SC, Unterman TG, Cohen P
J Biol Chem. 1999
PubMed ID: 10358075
Negative regulation of the forkhead transcription factor FKHR by Akt.
Tang ED, Nuñez G, Barr FG, Guan KL
J Biol Chem. 1999
PubMed ID: 10358014
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.
Nakae J, Park BC, Accili D
J Biol Chem. 1999
PubMed ID: 10347145
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC
Genomics. 1998
PubMed ID: 9479491
The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture.
Scheidler S, Fredericks WJ, Rauscher FJ, Barr FG, Vogt PK
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8790412
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma.
Davis RJ, Bennicelli JL, Macina RA, Nycum LM, Biegel JA, Barr FG
Hum Mol Genet. 1995
PubMed ID: 8634710
The alveolar rhabdomyosarcoma PAX3/FKHR fusion protein is a transcriptional activator.
Sublett JE, Jeon IS, Shapiro DN
Oncogene. 1995
PubMed ID: 7630639
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG, Rauscher FJ
Mol Cell Biol. 1995
PubMed ID: 7862145
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ, Emanuel BS, Rovera G, Barr FG
Nat Genet. 1993
PubMed ID: 8275086

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2308	56458	84482
EnsEMBL Gene(s)	ENSG00000150907	ENSMUSG00000044167	ENSRNOG00000013397
Unigene	Hs.370666	Mm.29891	Rn.116108
Homologene	FOXO1	Foxo1	Foxo1
OMIM	136533	N/A	N/A
GeneCards	FOXO1	N/A	N/A
Beta Cell Genomics	DT.317826	DT.101367712	N/A
Reactome	Q12778	Q9R1E0	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	2308	56458	84482

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
FOXO1	LRPPRC	IntAct, BioGRID	empirical	17050673
FOXO1	STUB1	BioGRID	empirical	19483080
FOXO1	CEBPA	MINT	empirical	17627282
FOXO1	CEBPB	HPRD	empirical	11893744
FOXO1	ATG7	BioGRID	empirical	20543840
FOXO1	CREBBP	HPRD, IntAct, BioGRID	empirical	10973497 15220471 16154098
FOXO1	PARP1	BioGRID	empirical	19281796
FOXO1	CTNNB1	HPRD	empirical	15905404
FOXO1	DYRK1A	HPRD	empirical	11311120
FOXO1	AKT1	HPRD, BioGRID	empirical	10358014 16076959
FOXO1	ESR1	HPRD, IntAct, BioGRID	empirical	11435445 11353774
FOXO1	FHL2	HPRD, IntAct	empirical	15692560
FOXO1	FOXG1	HPRD	empirical	15084259
FOXO1	SIRT2	BioGRID	empirical	15220471 20543840
FOXO1	SIRT1	HPRD, IntAct, BioGRID	empirical	15692560 15220471 16154098 21149440
FOXO1	G6PC	HPRD	empirical	11672436
FOXO1	GSK3B	HPRD	empirical	11980723
FOXO1	HNF4A	HPRD, BioGRID	empirical	12519792 19740748
FOXO1	HOXA5	HPRD, BioGRID	empirical	12163409
FOXO1	HOXA10	HPRD	empirical	12493691
FOXO1	HOXA11	BioGRID	empirical	19727442
FOXO1	AR	HPRD, IntAct	empirical	12482965 17202144
FOXO1	SMAD3	HPRD, BioGRID	empirical	15084259
FOXO1	SMAD4	HPRD, BioGRID	empirical	15084259
FOXO1	MDM2	BioGRID	empirical	19321440
FOXO1	PAK1	HPRD	empirical	10358014 12560069
FOXO1	NLK	BioGRID	empirical	20874444
FOXO1	PML	BioGRID	empirical	16154098
FOXO1	CSNK1G1	HPRD	empirical	11980723
FOXO1	PPARG	HPRD	empirical	12966085
FOXO1	RARA	HPRD, BioGRID	empirical	11353774
FOXO1	RFWD2	BioGRID	empirical	18815134
FOXO1	SKP2	BioGRID	empirical	15668399 19686743
FOXO1	SRC	HPRD, BioGRID	empirical	10973497
FOXO1	THRB	HPRD	empirical	11353774
FOXO1	TSC2	BioGRID	empirical	17077083
FOXO1	TXNRD1	BioGRID	empirical	11353774
FOXO1	UBC	BioGRID	empirical	15668399 13679577 19483080 19686743 19321440 17210752
FOXO1	YWHAG	HPRD, BioGRID	empirical	11237865
FOXO1	YWHAZ	HPRD, BioGRID	empirical	11237865
FOXO1	NR0B2	BioGRID	empirical	21081708
FOXO1	CCNB1	IntAct	empirical	18408765
FOXO1	HDAC4	IntAct	empirical	21565616
FOXO1	CDK1	IntAct	empirical	18408765