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FAP

Gene Description:   fibroblast activation protein, alpha; fibroblast activation protein Synonyms:   FAPA, FAP, DKFZp686G13158, Fap, DPPIV Orthologs:   Human FAP (protein-coding), Mouse Fap (protein-coding), Rat Fap (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
2q24.2	Human	chr2:162960873..163392761	0.43	30	rs1990760

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 2q24.2 Orthologous Region	Rat	chr3:44401046..44815836	0.41	5
Human 2q24.2 Orthologous Region	Mouse	chr2:62285610..62714487	0.43	5

(Human) GRCh37 - chr2:163027194..163101661 (74.47 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr2:62339000..62412132 (73.13 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr3:44457151..44525602 (68.45 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for FAP: The FAP interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs FAP   DPP4   HPRD  empirical  7911242  FAP   FAP   HPRD  empirical  9065413  FAP   PLAUR   HPRD, BioGRID  empirical  12376466

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 17   Metalloendopeptidase activity GO:0004222 Serine-type endopeptidase activity GO:0004252 Protein binding GO:0005515 Plasma membrane GO:0005886 Proteolysis GO:0006508 Peptidase activity GO:0008233 Serine-type peptidase activity GO:0008236 Dipeptidyl-peptidase activity GO:0008239 Negative regulation of extracellular matrix disassembly GO:0010716 Integral to membrane GO:0016021 Lamellipodium GO:0030027 Cell junction GO:0030054 Lamellipodium membrane GO:0031258 Protein homodimerization activity GO:0042803 Endothelial cell migration GO:0043542 Protein dimerization activity GO:0046983 Invadopodium membrane GO:0071438

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 17 Metalloendopeptidase activity GO:0004222 Serine-type endopeptidase activity GO:0004252 Protein binding GO:0005515 Plasma membrane GO:0005886 Proteolysis GO:0006508 Peptidase activity GO:0008233 Serine-type peptidase activity GO:0008236 Dipeptidyl-peptidase activity GO:0008239 Negative regulation of extracellular matrix disassembly GO:0010716 Integral to membrane GO:0016021 Lamellipodium GO:0030027 Cell junction GO:0030054 Lamellipodium membrane GO:0031258 Protein homodimerization activity GO:0042803 Endothelial cell migration GO:0043542 Protein dimerization activity GO:0046983 Invadopodium membrane GO:0071438

Type 1 Diabetes Publications: 1

• The association between the IFIH1 locus and type 1 diabetes.
  Qu HQ, Marchand L, Grabs R, Polychronakos C
  Diabetologia. 2008
  PubMed ID: 18071670
   
  

Publications: 66

• Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions.
  Huang Y, Simms AE, Mazur A, Wang S, León NR, Jones B, Aziz N, Kelly T
  Clin Exp Metastasis. 2011
  PubMed ID: 21604185
   
  
• Ultraviolet exposure of melanoma cells induces fibroblast activation protein-α in fibroblasts: Implications for melanoma invasion.
  Wäster P, Rosdahl I, Gilmore BF, Seifert O
  Int J Oncol. 2011
  PubMed ID: 21491083
   
  
• Fibroblast activation protein expression in Crohn's disease strictures.
  Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR, MacDonald TT
  Inflamm Bowel Dis. 2011
  PubMed ID: 20806341
   
  
• Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α.
  Keane FM, Nadvi NA, Yao TW, Gorrell MD
  FEBS J. 2011
  PubMed ID: 21314817
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Increased expression of fibroblast activation protein-alpha in keloid fibroblasts: implications for development of a novel treatment option.
  Dienus K, Bayat A, Gilmore BF, Seifert O
  Arch Dermatol Res. 2010
  PubMed ID: 20872224
   
  
• Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model.
  Wen Y, Wang CT, Ma TT, Li ZY, Zhou LN, Mu B, Leng F, Shi HS, Li YO, Wei YQ
  Cancer Sci. 2010
  PubMed ID: 20804499
   
  
• Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma.
  Abbas O, Richards JE, Mahalingam M
  Mod Pathol. 2010
  PubMed ID: 20711172
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts.
  Ospelt C, Mertens JC, Jüngel A, Brentano F, Maciejewska-Rodriguez H, Huber LC, Hemmatazad H, Wüest T, Knuth A, Gay RE, Michel BA, Gay S, Renner C, Bauer S
  Arthritis Rheum. 2010
  PubMed ID: 20155839
   
  
• Expression of dipeptidyl peptidase-IV activity and/or structure homologs in human meningiomas.
  Stremenová J, Mares V, Lisá V, Hilser M, Krepela E, Vanicková Z, Syrucek M, Soula O, Sedo A
  Int J Oncol. 2010
  PubMed ID: 20043068
   
  
• [Expression of FAP and alpha-SMA during the incised wound healing in mice skin].
  Gao Y, Peng X, Jin ZF, Fu ZJ
  Fa Yi Xue Za Zhi. 2009
  PubMed ID: 20225612
   
  
• Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice.
  Santos AM, Jung J, Aziz N, Kissil JL, Puré E
  J Clin Invest. 2009
  PubMed ID: 19920354
   
  
• TGF-beta induces fibroblast activation protein expression; fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM [corrected].
  Chen H, Yang WW, Wen QT, Xu L, Chen M
  Exp Mol Pathol. 2009
  PubMed ID: 19747910
   
  
• Histogenesis-specific expression of fibroblast activation protein and dipeptidylpeptidase-IV in human bone and soft tissue tumours.
  Dohi O, Ohtani H, Hatori M, Sato E, Hosaka M, Nagura H, Itoi E, Kokubun S
  Histopathology. 2009
  PubMed ID: 19817894
   
  
• Expression of fibroblast activation proteins in corneal stromal neovascularization.
  Wang T, Shi W
  Curr Eye Res. 2009
  PubMed ID: 19219682
   
  
• Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation.
  Hughes DS, Keynes RJ, Tannahill D
  BMC Dev Biol. 2009
  PubMed ID: 19463158
   
  
• Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells.
  Kennedy A, Dong H, Chen D, Chen WT
  Int J Cancer. 2009
  PubMed ID: 18823010
   
  
• Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma.
  Cohen SJ, Alpaugh RK, Palazzo I, Meropol NJ, Rogatko A, Xu Z, Hoffman JP, Weiner LM, Cheng JD
  Pancreas. 2008
  PubMed ID: 18665076
   
  
• FAP-alpha and uPA show different expression patterns in premalignant and malignant esophageal lesions.
  Goscinski MA, Suo Z, Flørenes VA, Vlatkovic L, Nesland JM, Giercksky KE
  Ultrastruct Pathol. 2008
  PubMed ID: 18570153
   
  
• Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites.
  Aggarwal S, Brennen WN, Kole TP, Schneider E, Topaloglu O, Yates M, Cotter RJ, Denmeade SR
  Biochemistry. 2008
  PubMed ID: 18095711
   
  
• The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.
  Ghersi G, Zhao Q, Salamone M, Yeh Y, Zucker S, Chen WT
  Cancer Res. 2006
  PubMed ID: 16651416
   
  
• Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity.
  Edosada CY, Quan C, Wiesmann C, Tran T, Sutherlin D, Reynolds M, Elliott JM, Raab H, Fairbrother W, Wolf BB
  J Biol Chem. 2006
  PubMed ID: 16410248
   
  
• Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity.
  Edosada CY, Quan C, Tran T, Pham V, Wiesmann C, Fairbrother W, Wolf BB
  FEBS Lett. 2006
  PubMed ID: 16480718
   
  
• Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein.
  Lee KN, Jackson KW, Christiansen VJ, Lee CS, Chun JG, McKee PA
  Blood. 2006
  PubMed ID: 16223769
   
  
• Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin.
  Wang XM, Yu DM, McCaughan GW, Gorrell MD
  Adv Exp Med Biol. 2006
  PubMed ID: 16700525
   
  
• Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.
  Milner JM, Kevorkian L, Young DA, Jones D, Wait R, Donell ST, Barksby E, Patterson AM, Middleton J, Cravatt BF, Clark IM, Rowan AD, Cawston TE
  Arthritis Res Ther. 2006
  PubMed ID: 16507127
   
  
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
  Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD
  J Proteome Res. 2005
  PubMed ID: 16335952
   
  
• Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.
  Wang XM, Yu DM, McCaughan GW, Gorrell MD
  Hepatology. 2005
  PubMed ID: 16175601
   
  
• 'Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer'.
  Iwasa S, Okada K, Chen WT, Jin X, Yamane T, Ooi A, Mitsumata M
  Cancer Lett. 2005
  PubMed ID: 16196122
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Induction of CD4(+) and CD8(+) T-cell responses to the human stromal antigen, fibroblast activation protein: implication for cancer immunotherapy.
  Fassnacht M, Lee J, Milazzo C, Boczkowski D, Su Z, Nair S, Gilboa E
  Clin Cancer Res. 2005
  PubMed ID: 16061874
   
  
• Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.
  Aertgeerts K, Levin I, Shi L, Snell GP, Jennings A, Prasad GS, Zhang Y, Kraus ML, Salakian S, Sridhar V, Wijnands R, Tennant MG
  J Biol Chem. 2005
  PubMed ID: 15809306
   
  
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
  Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
  Nature. 2005
  PubMed ID: 15815621
   
  
• Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth.
  Cheng JD, Valianou M, Canutescu AA, Jaffe EK, Lee HO, Wang H, Lai JH, Bachovchin WW, Weiner LM
  Mol Cancer Ther. 2005
  PubMed ID: 15767544
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• FAPalpha, a surface peptidase expressed during wound healing, is a tumor suppressor.
  Ramirez-Montagut T, Blachere NE, Sviderskaya EV, Bennett DC, Rettig WJ, Garin-Chesa P, Houghton AN
  Oncogene. 2004
  PubMed ID: 15133496
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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