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ALDH2

Gene Description:   aldehyde dehydrogenase 2, mitochondrial; aldehyde dehydrogenase 2 family (mitochondrial) Synonyms:   Ahd5, Ahd-5, ALDHI, ALDH2, Aldh2, MGC1806, ALDM, ALDH-E2 Orthologs:   Human ALDH2 (protein-coding), Mouse Aldh2 (protein-coding), Rat Aldh2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid Human-Rat: HomoloGene, MGD, RGD, Inparanoid Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
12q24.12	Human	chr12:111287726..113238728	1.95	126	rs3184504

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 12q24.12 Orthologous Region	Mouse	chr5:121453514..122577854	1.12	22
Human 12q24.12 Orthologous Region	Rat	chr12:35633402..36684230	1.05	12

(Human) GRCh37 - chr12:112204346..112247789 (43.44 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr5:122016036..122043833 (27.80 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr12:36081778..36116445 (34.67 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for ALDH2: The ALDH2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs ALDH2   C14orf1   HPRD, MINT, IntAct, BioGRID  empirical  16169070  ALDH2   CRMP1   HPRD, MINT, IntAct, BioGRID  empirical  16169070  ALDH2   DLG4   IntAct  empirical  19455133  ALDH2   ALDH2   HPRD  empirical  10631996  12795606  9195888  ALDH2   FHIT   IntAct  empirical  18319262  ALDH2   ITGB3BP   IntAct  empirical  16169070  ALDH2   GABARAPL1   IntAct  empirical  20562859  ALDH2   HNRNPK   IntAct  empirical  16518874  ALDH2   HSPD1   HPRD, BioGRID  empirical  12387818  ALDH2   HSPE1   HPRD, BioGRID  empirical  12387818  ALDH2   EIF6   HPRD  empirical  16169070  ALDH2   FAM45A   IntAct  empirical  16169070  ALDH2   C2orf18   HPRD, MINT, IntAct, BioGRID  empirical  16169070  ALDH2   SLC2A4   IntAct  empirical  16396496  ALDH2   UBA5   IntAct, BioGRID  empirical  20562859  ALDH2   IGSF21   HPRD, MINT, IntAct, BioGRID  empirical  16169070  ALDH2   UNC119   HPRD, MINT, IntAct, BioGRID  empirical  16169070

View all

KEGG Network: 14   Arginine and proline metabolism Human - 330 Mouse - 330 Rat - 330 Ascorbate and aldarate metabolism Human - 53 Mouse - 53 Rat - 53 beta-Alanine metabolism Human - 410 Mouse - 410 Rat - 410 Fatty acid metabolism Human - 71 Mouse - 71 Rat - 71 Glycerolipid metabolism Human - 561 Mouse - 561 Rat - 561 Glycolysis / Gluconeogenesis Human - 10 Mouse - 10 Rat - 10 Histidine metabolism Human - 340 Mouse - 340 Rat - 340 Lysine degradation Human - 310 Mouse - 310 Rat - 310 Metabolic pathways Human - 1100 Mouse - 1100 Rat - 1100 Pentose and glucuronate interconversions Human - 40 Mouse - 40 Rat - 40 Propanoate metabolism Human - 640 Mouse - 640 Rat - 640 Pyruvate metabolism Human - 620 Mouse - 620 Rat - 620 Tryptophan metabolism Human - 380 Mouse - 380 Rat - 380 Valine, leucine and isoleucine degradation Human - 280 Mouse - 280 Rat - 280

Biocarta: None available   None available.

Reactome: 8   Biological oxidations REACT_13433 Ethanol oxidation REACT_34 Metabolism of serotonin REACT_15532 Neurotransmitter Clearance In The Synaptic Cleft REACT_13583 Phase 1 - Functionalization of compounds REACT_13705 Serotonin clearance from the synaptic cleft REACT_15391 Synaptic Transmission REACT_13685 Transmission across Chemical Synapses REACT_13477

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 12   Aldehyde dehydrogenase (NAD) activity GO:0004029 Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 Mitochondrion GO:0005739 Mitochondrial matrix GO:0005759 Carbohydrate metabolic process GO:0005975 Alcohol metabolic process GO:0006066 Ethanol oxidation GO:0006069 Xenobiotic metabolic process GO:0006805 Synaptic transmission GO:0007268 Electron carrier activity GO:0009055 Oxidoreductase activity GO:0016491 Neurotransmitter biosynthetic process GO:0042136

	KEGG Network: 14 Arginine and proline metabolism Human - 330 Mouse - 330 Rat - 330 Ascorbate and aldarate metabolism Human - 53 Mouse - 53 Rat - 53 beta-Alanine metabolism Human - 410 Mouse - 410 Rat - 410 Fatty acid metabolism Human - 71 Mouse - 71 Rat - 71 Glycerolipid metabolism Human - 561 Mouse - 561 Rat - 561 Glycolysis / Gluconeogenesis Human - 10 Mouse - 10 Rat - 10 Histidine metabolism Human - 340 Mouse - 340 Rat - 340 Lysine degradation Human - 310 Mouse - 310 Rat - 310 Metabolic pathways Human - 1100 Mouse - 1100 Rat - 1100 Pentose and glucuronate interconversions Human - 40 Mouse - 40 Rat - 40 Propanoate metabolism Human - 640 Mouse - 640 Rat - 640 Pyruvate metabolism Human - 620 Mouse - 620 Rat - 620 Tryptophan metabolism Human - 380 Mouse - 380 Rat - 380 Valine, leucine and isoleucine degradation Human - 280 Mouse - 280 Rat - 280
	Biocarta: None available
	Reactome: 8 Biological oxidations REACT_13433 Ethanol oxidation REACT_34 Metabolism of serotonin REACT_15532 Neurotransmitter Clearance In The Synaptic Cleft REACT_13583 Phase 1 - Functionalization of compounds REACT_13705 Serotonin clearance from the synaptic cleft REACT_15391 Synaptic Transmission REACT_13685 Transmission across Chemical Synapses REACT_13477
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 12 Aldehyde dehydrogenase (NAD) activity GO:0004029 Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 Mitochondrion GO:0005739 Mitochondrial matrix GO:0005759 Carbohydrate metabolic process GO:0005975 Alcohol metabolic process GO:0006066 Ethanol oxidation GO:0006069 Xenobiotic metabolic process GO:0006805 Synaptic transmission GO:0007268 Electron carrier activity GO:0009055 Oxidoreductase activity GO:0016491 Neurotransmitter biosynthetic process GO:0042136

Type 1 Diabetes Publications: 3

• Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
  Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG
  Nat Genet. 2007
  PubMed ID: 17554260
   
  
• Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes.
  Murata C, Taniyama M, Kuriyama S, Muramatsu T, Atsumi Y, Matsuoka K, Suzuki Y
  Diabetes Res Clin Pract. 2004
  PubMed ID: 15563966
   
  
• Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus.
  Suzuki Y, Matsuura N, Suzuki S, Muramatsu T, Taniyama M, Ohta S, Higuchi S, Tsukahara M, Atusmi Y, Matsuoka K
  Diabetes Res Clin Pract. 2003
  PubMed ID: 12706323
   
  

Publications: 439

• p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia.
  Yokoyama A, Tanaka Y, Yokoyama T, Mizukami T, Matsui T, Maruyama K, Omori T
  Cancer Lett. 2011
  PubMed ID: 21601984
   
  
• Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation.
  Wenzl MV, Beretta M, Griesberger M, Russwurm M, Koesling D, Schmidt K, Mayer B, Gorren AC
  Mol Pharmacol. 2011
  PubMed ID: 21536753
   
  
• ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population.
  Ji YB, Tae K, Ahn TH, Lee SH, Kim KR, Park CW, Park BL, Shin HD
  Oral Oncol. 2011
  PubMed ID: 21576033
   
  
• [Alcohol metabolism at moderate drinking in healthy men. Comparison between differences of alcohol beverages, with and without meal, and genetic polymorphism].
  Oshima S, Haseba T, Masuda C, Abe Y, Sami M, Kanda T, Ohno Y
  Nihon Arukoru Yakubutsu Igakkai Zasshi. 2011
  PubMed ID: 21861333
   
  
• Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
  Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, Katsuya T, Yokota M, Kim YJ, Ong RT, Nabika T, Gu D, Chang LC, Kokubo Y, Huang W, Ohnaka K, Yamori Y, Nakashima E, Jaquish CE, Lee JY, Seielstad M, Isono M, Hixson JE, Chen YT, Miki T, Zhou X, Sugiyama T, Jeon JP, Liu JJ, Takayanagi R, Kim SS, Aung T, Sung YJ, Zhang X, Wong TY, Han BG, Kobayashi S, Ogihara T, Zhu D, Iwai N, Wu JY, Teo YY, Tai ES, Cho YS, He J
  Nat Genet. 2011
  PubMed ID: 21572416
   
  
• NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2.
  Gonnella TP, Leedahl TS, Karlstad JP, Picklo MJ
  Chem Biol Interact. 2011
  PubMed ID: 21276780
   
  
• Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians.
  Hao PP, Chen YG, Wang JL, Wang XL, Zhang Y
  Can J Neurol Sci. 2011
  PubMed ID: 21515512
   
  
• Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice.
  Choi H, Tostes RC, Webb RC
  J Am Soc Hypertens. 2011
  PubMed ID: 21459068
   
  
• Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice.
  Shimizu Y, Sakai A, Menuki K, Mori T, Isse T, Oyama T, Kawamoto T, Nakamura T
  Bone. 2011
  PubMed ID: 21256255
   
  
• Alcohol ingestion and colorectal neoplasia: a meta-analysis based on a Mendelian randomization approach.
  Wang J, Wang H, Chen Y, Hao P, Zhang Y
  Colorectal Dis. 2011
  PubMed ID: 21114754
   
  
• Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.
  Takeuchi F, Isono M, Nabika T, Katsuya T, Sugiyama T, Yamaguchi S, Kobayashi S, Ogihara T, Yamori Y, Fujioka A, Kato N
  Circ J. 2011
  PubMed ID: 21372407
   
  
• Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro.
  Oelze M, Knorr M, Schell R, Kamuf J, Pautz A, Art J, Wenzel P, Münzel T, Kleinert H, Daiber A
  J Biol Chem. 2011
  PubMed ID: 21252222
   
  
• A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
  McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Bucur A, Bencko V, Holcatova I, Janout V, Foretova L, Lagiou P, Trichopoulos D, Benhamou S, Bouchardy C, Ahrens W, Merletti F, Richiardi L, Talamini R, Barzan L, Kjaerheim K, Macfarlane GJ, Macfarlane TV, Simonato L, Canova C, Agudo A, Castellsagué X, Lowry R, Conway DI, McKinney PA, Healy CM, Toner ME, Znaor A, Curado MP, Koifman S, Menezes A, Wünsch-Filho V, Neto JE, Garrote LF, Boccia S, Cadoni G, Arzani D, Olshan AF, Weissler MC, Funkhouser WK, Luo J, Lubiński J, Trubicka J, Lener M, Oszutowska D, Schwartz SM, Chen C, Fish S, Doody DR, Muscat JE, Lazarus P, Gallagher CJ, Chang SC, Zhang ZF, Wei Q, Sturgis EM, Wang LE, Franceschi S, Herrero R, Kelsey KT, McClean MD, Marsit CJ, Nelson HH, Romkes M, Buch S, Nukui T, Zhong S, Lacko M, Manni JJ, Peters WH, Hung RJ, McLaughlin J, Vatten L, Njølstad I, Goodman GE, Field JK, Liloglou T, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Quirós JR, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Khaw KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Välk K, Voodern T, Metspalu A, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Blanché H, Gut IG, Galan P, Heath S, Hashibe M, Hayes RB, Boffetta P, Lathrop M, Brennan P
  PLoS Genet. 2011
  PubMed ID: 21437268
   
  
• Inhibition of aldehyde dehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats.
  Wang J, Wang H, Hao P, Xue L, Wei S, Zhang Y, Chen Y
  Mol Med. 2011
  PubMed ID: 20957334
   
  
• Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men.
  Baik I, Cho NH, Kim SH, Han BG, Shin C
  Am J Clin Nutr. 2011
  PubMed ID: 21270382
   
  
• Malondialdehyde inhibits an AMPK-mediated nuclear translocation and repression activity of ALDH2 in transcription.
  Choi JW, Kim JH, Cho SC, Ha MK, Song KY, Youn HD, Park SC
  Biochem Biophys Res Commun. 2011
  PubMed ID: 21130747
   
  
• Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study.
  Hasi T, Hao L, Yang L, Su XL
  Genet Mol Res. 2011
  PubMed ID: 21476199
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
  Zhang GH, Mai RQ, Huang B
  World J Gastroenterol. 2010
  PubMed ID: 21157980
   
  
• Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholism.
  Lu RB, Lee JF, Huang SY, Lee SY, Chang YH, Kuo PH, Chen SL, Chen SH, Chu CH, Lin WW, Wu PL, Ko HC
  Addict Biol. 2010
  PubMed ID: 21070510
   
  
• [Activation of mitochondrial aldehyde dehydrogenase 2 and inhibition of mitochondrial permeability transition pore involved in cardioprotection of ethanol postconditioning].
  Li ZH, Jiang CR, Xia ML, Ye HW, Guan SD, Gao Q
  Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010
  PubMed ID: 21166048
   
  
• Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
  Tanaka F, Yamamoto K, Suzuki S, Inoue H, Tsurumaru M, Kajiyama Y, Kato H, Igaki H, Furuta K, Fujita H, Tanaka T, Tanaka Y, Kawashima Y, Natsugoe S, Setoyama T, Tokudome S, Mimori K, Haraguchi N, Ishii H, Mori M
  Gut. 2010
  PubMed ID: 20833657
   
  
• A genome-wide association study of hypertension-related phenotypes in a Japanese population.
  Hiura Y, Tabara Y, Kokubo Y, Okamura T, Miki T, Tomoike H, Iwai N
  Circ J. 2010
  PubMed ID: 20877124
   
  
• Evaluating a Cognitive Model of ALDH2 and Drinking Behavior.
  Hendershot CS, Witkiewitz K, George WH, Wall TL, Otto JM, Liang T, Larimer ME
  Alcohol Clin Exp Res. 2010
  PubMed ID: 21039630
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis.
  Yang SJ, Yokoyama A, Yokoyama T, Huang YC, Wu SY, Shao Y, Niu J, Wang J, Liu Y, Zhou XQ, Yang CX
  World J Gastroenterol. 2010
  PubMed ID: 20806441
   
  
• Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.
  Yao L, Fan P, Arolfo M, Jiang Z, Olive MF, Zablocki J, Sun HL, Chu N, Lee J, Kim HY, Leung K, Shryock J, Blackburn B, Diamond I
  Nat Med. 2010
  PubMed ID: 20729865
   
  
• Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat.
  Badejo AM, Hodnette C, Dhaliwal JS, Casey DB, Pankey E, Murthy SN, Nossaman BD, Hyman AL, Kadowitz PJ
  Am J Physiol Heart Circ Physiol. 2010
  PubMed ID: 20543077
   
  
• Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East Asian populations.
  Hao PP, Xue L, Wang XL, Chen YG, Wang JL, Ji WQ, Xu F, Wei SJ, Zhang Y
  Atherosclerosis. 2010
  PubMed ID: 20541757
   
  
• Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay.
  Weng H, Weng Z, Lu Y, Nakayama K, Morimoto K
  Mutat Res. 2010
  PubMed ID: 20685249
   
  
• Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2.
  Hendershot CS, Otto JM, Collins SE, Liang T, Wall TL
  Ann Behav Med. 2010
  PubMed ID: 20652463
   
  
• Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population.
  Kayaaltı Z, Söylemezoğlu T
  Alcohol. 2010
  PubMed ID: 20598484
   
  
• The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder.
  Lee SY, Chen SL, Chang YH, Chen SH, Chu CH, Huang SY, Tzeng NS, Wang CL, Lee IH, Yeh TL, Yang YK, Lu RB
  Pharmacogenet Genomics. 2010
  PubMed ID: 20577142
   
  
• Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.
  Oze I, Matsuo K, Hosono S, Ito H, Kawase T, Watanabe M, Suzuki T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Tajima K, Tanaka H
  Cancer Sci. 2010
  PubMed ID: 20518787
   
  
• The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.
  Guo YJ, Chen L, Bai YP, Li L, Sun J, Zhang GG, Yang TL, Xia J, Li YJ, Chen XP
  Atherosclerosis. 2010
  PubMed ID: 20417517
   
  
• Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases.
  Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J
  J Mol Cell Cardiol. 2010
  PubMed ID: 20362583
   
  
• Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia.
  Zhou YZ, Diao YT, Li H, Li HQ, Ma Q, Cui J
  World J Gastroenterol. 2010
  PubMed ID: 20632450
   
  
• Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer.
  Miyasaka K, Hosoya H, Tanaka Y, Uegaki S, Kino K, Shimokata H, Kawanami T, Funakoshi A
  Geriatr Gerontol Int. 2010
  PubMed ID: 20590827
   
  
• Network organization of the human autophagy system.
  Behrends C, Sowa ME, Gygi SP, Harper JW
  Nature. 2010
  PubMed ID: 20562859
   
  
• MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence.
  Lee SY, Hahn CY, Lee JF, Huang SY, Chen SL, Kuo PH, Lee IH, Yeh TL, Yang YK, Chen SH, Ko HC, Lu RB
  Alcohol Clin Exp Res. 2010
  PubMed ID: 20477771
   
  
• Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men.
  Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T
  Alcohol Clin Exp Res. 2010
  PubMed ID: 20477767
   
  
• Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria.
  Oikawa T, Iijima K, Koike T, Uno K, Horii T, Iwai W, Abe Y, Asano N, Imatani A, Shimosegawa T
  Scand J Gastroenterol. 2010
  PubMed ID: 20521872
   
  
• Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes.
  Kim YD, Eom SY, Zhang YW, Kim H, Park JD, Yu SD, Lee CH, Arashidani K, Kawamoto T, Kim H
  Hum Exp Toxicol. 2010
  PubMed ID: 20488846
   
  
• Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
  Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
  Cancer Prev Res (Phila Pa). 2010
  PubMed ID: 20403997
   
  
• Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
  Martins-de-Souza D, Schmitt A, Röder R, Lebar M, Schneider-Axmann T, Falkai P, Turck CW
  J Psychiatr Res. 2010
  PubMed ID: 20381070
   
  
• Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.
  Ji F, Wang W, Xia ZL, Zheng YJ, Qiu YL, Wu F, Miao WB, Jin RF, Qian J, Jin L, Zhu YL, Christiani DC
  Carcinogenesis. 2010
  PubMed ID: 20100738
   
  
• Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population.
  Park JY, Matsuo K, Suzuki T, Ito H, Hosono S, Kawase T, Watanabe M, Oze I, Hida T, Yatabe Y, Mitsudomi T, Takezaki T, Tajima K, Tanaka H
  Carcinogenesis. 2010
  PubMed ID: 20093384
   
  
• Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.
  Budas GR, Disatnik MH, Chen CH, Mochly-Rosen D
  J Mol Cell Cardiol. 2010
  PubMed ID: 19913552
   
  
• Genome-wide association study of hematological and biochemical traits in a Japanese population.
  Kamatani Y, Matsuda K, Okada Y, Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N
  Nat Genet. 2010
  PubMed ID: 20139978
   
  
• Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women.
  Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Khuhaprema T, Yoshida T
  Breast Cancer Res Treat. 2010
  PubMed ID: 20180013
   
  
• Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population.
  Hishimoto A, Fukutake M, Mouri K, Nagasaki Y, Asano M, Ueno Y, Nishiguchi N, Shirakawa O
  Genes Brain Behav. 2010
  PubMed ID: 20180859
   
  
• Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes.
  Martínez C, Galván S, Garcia-Martin E, Ramos MI, Gutiérrez-Martín Y, Agúndez JA
  Hepatology. 2010
  PubMed ID: 20101753
   
  
• Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.
  Perez-Miller S, Younus H, Vanam R, Chen CH, Mochly-Rosen D, Hurley TD
  Nat Struct Mol Biol. 2010
  PubMed ID: 20062057
   
  
• Association of ALDH2 genotypes with periodontitis progression.
  Nishida N, Tanaka M, Sekine S, Takeshita T, Nakayama K, Morimoto K, Shizukuishi S
  J Dent Res. 2010
  PubMed ID: 20042735
   
  
• Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population.
  Ding JH, Li SP, Cao HX, Wu JZ, Gao CM, Liu YT, Zhou JN, Chang J, Yao GH
  J Hum Genet. 2010
  PubMed ID: 20010786
   
  
• Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients.
  Zhou S, Huriletemuer, Wang J, Zhang C, Zhao S, Wang de S, Wang B, Ma X
  Neurosci Lett. 2010
  PubMed ID: 19914339
   
  
• Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1.
  Beretta M, Gorren AC, Wenzl MV, Weis R, Russwurm M, Koesling D, Schmidt K, Mayer B
  J Biol Chem. 2010
  PubMed ID: 19906643
   
  
• Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males.
  Cao HX, Li SP, Wu JZ, Gao CM, Su P, Liu YT, Zhou JN, Ding JH
  Asian Pac J Cancer Prev. 2010
  PubMed ID: 21133627
   
  
• High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition.
  Awad O, Yustein JT, Shah P, Gul N, Katuri V, O'Neill A, Kong Y, Brown ML, Toretsky JA, Loeb DM
  PLoS One. 2010
  PubMed ID: 21085683
   
  
• Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
  Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
  PLoS One. 2010
  PubMed ID: 20877624
   
  
• The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.
  Husemoen LL, Jørgensen T, Borch-Johnsen K, Hansen T, Pedersen O, Linneberg A
  PLoS One. 2010
  PubMed ID: 20700531
   
  
• The polymorphism in aldehyde dehydrogenase-2 gene is associated with elevated plasma levels of high-sensitivity C-reactive protein in the early phase of myocardial infarction.
  Bian Y, Chen YG, Xu F, Xue L, Ji WQ, Zhang Y
  Tohoku J Exp Med. 2010
  PubMed ID: 20467232
   
  
• Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy.
  Canova C, Richiardi L, Merletti F, Pentenero M, Gervasio C, Tanturri G, Garzino-Demo P, Pecorari G, Talamini R, Barzan L, Sulfaro S, Franchini G, Muzzolini C, Bordin S, Pugliese GN, Macrì E, Simonato L
  Tumori. 2010
  PubMed ID: 20437850
   
  
• [Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]
  Ye X, Peng T, Liu T, Su Z, Xiao K, Shang L, Su M, Li L
  Wei Sheng Yan Jiu. 2010
  PubMed ID: 20364586
   
  
• Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians.
  Linneberg A, Gonzalez-Quintela A, Vidal C, Jørgensen T, Fenger M, Hansen T, Pedersen O, Husemoen LL
  Clin Exp Allergy. 2010
  PubMed ID: 20205700
   
  
• Alcohol and aldehyde dehydrogenase polymorphisms in Chinese and Indian populations.
  Tan EC, Lim L, Leong JY, Lim JY, Lee A, Yang J, Tan CH, Winslow M
  Subst Use Misuse. 2010
  PubMed ID: 20025435
   
  
• ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients.
  Xu F, Chen Y, Lv R, Zhang H, Tian H, Bian Y, Feng J, Sun Y, Li R, Wang R, Zhang Y
  Hypertens Res. 2010
  PubMed ID: 19876063
   
  
• Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele.
  Gordillo-Bastidas E, Panduro A, Gordillo-Bastidas D, Zepeda-Carrillo EA, García-Bañuelos JJ, Muñoz-Valle JF, Bastidas-Ramírez BE
  Alcohol Clin Exp Res. 2010
  PubMed ID: 19860798
   
  
• Integrative predictive model of coronary artery calcification in atherosclerosis.
  McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
  Circulation. 2009
  PubMed ID: 19948975
   
  
• Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics.
  Kim SG
  Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009
  PubMed ID: 20077761
   
  
• Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes.
  Ran D, Schubert M, Pietsch L, Taubert I, Wuchter P, Eckstein V, Bruckner T, Zoeller M, Ho AD
  Exp Hematol. 2009
  PubMed ID: 19819294
   
  
• Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.
  Gemignani F, Neri M, Bottari F, Barale R, Canessa PA, Canzian F, Ceppi M, Spitaleri I, Cipollini M, Ivaldi GP, Mencoboni M, Scaruffi P, Tonini GP, Ugolini D, Mutti L, Bonassi S, Landi S
  Mutat Res. 2009
  PubMed ID: 19751749
   
  
• Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans.
  Park JW, Ji YI, Choi YH, Kang MY, Jung E, Cho SY, Cho HY, Kang BK, Joung YS, Kim DH, Park SC, Park J
  Exp Mol Med. 2009
  PubMed ID: 19641380
   
  
• Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart.
  Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K
  Circ Res. 2009
  PubMed ID: 19815821
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice.
  Yu HS, Oyama T, Isse T, Kitakawa K, Ogawa M, Pham TT, Kawamoto T
  Toxicol Mech Methods. 2009
  PubMed ID: 19874182
   
  
• Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population.
  Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19861527
   
  
• Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
  Cui R, Kamatani Y, Takahashi A, Usami M, Hosono N, Kawaguchi T, Tsunoda T, Kamatani N, Kubo M, Nakamura Y, Matsuda K
  Gastroenterology. 2009
  PubMed ID: 19698717
   
  
• Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models.
  Jamal M, Ameno K, Miki T, Wang W, Kumihashi M, Isse T, Kawamoto T, Kitagawa K, Nakayama K, Ijiri I, Kinoshita H
  Brain Res. 2009
  PubMed ID: 19664611
   
  
• Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.
  Akbari MR, Malekzadeh R, Shakeri R, Nasrollahzadeh D, Foumani M, Sun Y, Pourshams A, Sadjadi A, Jafari E, Sotoudeh M, Kamangar F, Boffetta P, Dawsey SM, Ghadirian P, Narod SA
  Cancer Res. 2009
  PubMed ID: 19826048
   
  
• Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris.
  Zhao Y, Lei M, Wu Y, Zhang Z, Wang C
  Sci China C Life Sci. 2009
  PubMed ID: 19911129
   
  
• ALDH2, ADH1B and alcohol expectancies: integrating genetic and learning perspectives.
  Hendershot CS, Neighbors C, George WH, McCarthy DM, Wall TL, Liang T, Larimer ME
  Psychol Addict Behav. 2009
  PubMed ID: 19769429
   
  
• A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population.
  Yang H, Zhou Y, Zhou Z, Liu J, Yuan X, Matsuo K, Takezaki T, Tajima K, Cao J
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19706845
   
  
• Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis.
  Lee CH, Wu DC, Wu IC, Goan YG, Lee JM, Chou SH, Chan TF, Huang HL, Hung YH, Huang MC, Lai TC, Wang TN, Lan CC, Tsai S, Lin WY, Wu MT
  Int J Cancer. 2009
  PubMed ID: 19449376
   
  
• Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
  Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
  Eur Urol. 2009
  PubMed ID: 19692168
   
  
• Interaction among genes influencing ethanol metabolism and sex is association with alcohol use disorders in a Tibet population.
  Guo W, Wang Q, Lanzi G, Luobu O, Ma X, Wang Y, Zhen P, Ji Y, Wei G, Wang Z, Deng W, Zhuoma B, Shi X, Yan C, He C, Liu X, Wu Y, Luo H, Collier DA, Ball D, Li T, Hu X
  Am J Med Genet B Neuropsychiatr Genet. 2009
  PubMed ID: 19655364
   
  
• Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele.
  Chen YC, Peng GS, Tsao TP, Wang MF, Lu RB, Yin SJ
  Pharmacogenet Genomics. 2009
  PubMed ID: 19584771
   
  
• Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress.
  Li SY, Gilbert SA, Li Q, Ren J
  J Mol Cell Cardiol. 2009
  PubMed ID: 19344727
   
  
• An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men.
  Shin S, Stewart R, Ferri CP, Kim JM, Shin IS, Kim SW, Yang SJ, Yoon JS
  Int J Geriatr Psychiatry. 2009
  PubMed ID: 19637400
   
  
• Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2.
  Wenzl MV, Beretta M, Gorren AC, Zeller A, Baral PK, Gruber K, Russwurm M, Koesling D, Schmidt K, Mayer B
  J Biol Chem. 2009
  PubMed ID: 19506075
   
  
• PTEN identified as important risk factor of chronic obstructive pulmonary disease.
  Hosgood HD, Menashe I, He X, Chanock S, Lan Q
  Respir Med. 2009
  PubMed ID: 19625176
   
  
• Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?
  Budas GR, Disatnik MH, Mochly-Rosen D
  Trends Cardiovasc Med. 2009
  PubMed ID: 20005475
   
  
• Is habitual alcohol drinking associated with reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese?
  Lu Y, Morimoto K
  Mutagenesis. 2009
  PubMed ID: 19286920
   
  
• Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells.
  Nishimura FT, Kimura Y, Abe S, Fukunaga T, Saijoh K
  Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009
  PubMed ID: 19618839
   
  
• MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder.
  Lee SY, Hahn CY, Lee JF, Chen SL, Chen SH, Yeh TL, Kuo PH, Lee IH, Yang YK, Huang SY, Ko HC, Lu RB
  Alcohol Clin Exp Res. 2009
  PubMed ID: 19302089
   
  
• Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males.
  Ding JH, Li SP, Cao HX, Wu JZ, Gao CM, Su P, Liu YT, Zhou JN, Chang J, Yao GH
  World J Gastroenterol. 2009
  PubMed ID: 19452585
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• [Genetic polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 associated with the susceptibility on esophageal cancer]
  Ding JH, Li SP, Cao HX, Wu JZ, Gao CM, Su P, Liu YT, Zhou JN, Chang J, Yao GH
  Zhonghua Liu Xing Bing Xue Za Zhi. 2009
  PubMed ID: 19799139
   
  
• Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant.
  Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov VA, Qin Z, Khaliq S, Lee MY, Yang Y, Mohyuddin A, Gurwitz D, Mehdi SQ, Rogaev E, Jin L, Yankovsky NK, Kidd JR, Kidd KK
  Ann Hum Genet. 2009
  PubMed ID: 19456322
   
  
• Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics.
  Kimura M, Sawayama T, Matsushita S, Higuchi S, Kashima H
  Alcohol Clin Exp Res. 2009
  PubMed ID: 19298328
   
  
• Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults.
  Hendershot CS, Collins SE, George WH, Wall TL, McCarthy DM, Liang T, Larimer ME
  Alcohol Clin Exp Res. 2009
  PubMed ID: 19298323
   
  
• Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver.
  Guo R, Zhong L, Ren J
  Clin Exp Pharmacol Physiol. 2009
  PubMed ID: 19215238
   
  
• Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
  Environ Mol Mutagen. 2009
  PubMed ID: 19170196
   
  
• A promoter polymorphism in the ALDH2 gene affects its basal and acetaldehyde/ethanol-induced gene expression in human peripheral blood leukocytes and HepG2 cells.
  Kimura Y, Nishimura FT, Abe S, Fukunaga T, Tanii H, Saijoh K
  Alcohol Alcohol. 2009
  PubMed ID: 19144977
   
  
• Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys.
  Luo HR, Wu GS, Pakstis AJ, Tong L, Oota H, Kidd KK, Zhang YP
  Gene. 2009
  PubMed ID: 19393179
   
  
• Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.
  Doser TA, Turdi S, Thomas DP, Epstein PN, Li SY, Ren J
  Circulation. 2009
  PubMed ID: 19332462
   
  
• Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India.
  Vaswani M, Prasad P, Kapur S
  Hum Genomics. 2009
  PubMed ID: 19403456
   
  
• Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
  Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P
  Cancer Res. 2009
  PubMed ID: 19339270
   
  
• Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
  Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC
  Pediatrics. 2009
  PubMed ID: 19336370
   
  
• Lipid hydroperoxides in human plasma after ethanol consumption.
  Asano M, Nushida H, Adachi J, Nagasaki Y, Nakagawa K, Kuse A, Ueno Y
  Leg Med (Tokyo). 2009
  PubMed ID: 19261511
   
  
• 5HTT polymorphisms are associated with job stress in Japanese workers.
  Katsuyama H, Tomita M, Okuyama T, Hidaka K, Watanabe Y, Tamechika Y, Fushimi S, Saijoh K
  Leg Med (Tokyo). 2009
  PubMed ID: 19251454
   
  
• Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups.
  Kang TS, Woo SW, Park HJ, Lee Y, Roh J
  J Clin Pharm Ther. 2009
  PubMed ID: 19250143
   
  
• Alcohol Dehydrogenase 2 Genotype and Risk for Migraine.
  García-Martín E, Martínez C, Serrador M, Alonso-Navarro H, Navacerrada F, Agúndez JA, Jiménez-Jiménez FJ
  Headache. 2009
  PubMed ID: 19486361
   
  
• Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population.
  Tsuchihashi-Makaya M, Serizawa M, Yanai K, Katsuya T, Takeuchi F, Fujioka A, Yamori Y, Ogihara T, Kato N
  Hypertens Res. 2009
  PubMed ID: 19262484
   
  
• Increased formation of gastric N(2)-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase-2 knockout mice treated with ethanol.
  Nagayoshi H, Matsumoto A, Nishi R, Kawamoto T, Ichiba M, Matsuda T
  Mutat Res. 2009
  PubMed ID: 19101651
   
  
• Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.
  Levi BP, Yilmaz OH, Duester G, Morrison SJ
  Blood. 2009
  PubMed ID: 18971422
   
  
• Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer.
  Druesne-Pecollo N, Tehard B, Mallet Y, Gerber M, Norat T, Hercberg S, Latino-Martel P
  Lancet Oncol. 2009
  PubMed ID: 19185835
   
  
• Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects.
  Kimura Y, Nishimura FT, Abe S, Fukunaga T, Tanii H, Saijoh K
  J Toxicol Sci. 2009
  PubMed ID: 19182438
   
  
• Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis.
  Macgregor S, Lind PA, Bucholz KK, Hansell NK, Madden PA, Richter MM, Montgomery GW, Martin NG, Heath AC, Whitfield JB
  Hum Mol Genet. 2009
  PubMed ID: 18996923
   
  
• Genetical genomic determinants of alcohol consumption in rats and humans.
  Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism
  BMC Biol. 2009
  PubMed ID: 19874574
   
  
• Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan.
  Kawase T, Matsuo K, Hiraki A, Suzuki T, Watanabe M, Iwata H, Tanaka H, Tajima K
  J Epidemiol. 2009
  PubMed ID: 19667493
   
  
• Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2 Polymorphisms in Uzbekistan.
  Ahn KS, Abdiev S, Rahimov B, Malikov Y, Bahramov S, Okada R, Naito M, Hamajima N
  Asian Pac J Cancer Prev. 2009
  PubMed ID: 19469618
   
  
• Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
  Saito A, Kawamoto M, Kamatani N
  J Hum Genet. 2009
  PubMed ID: 19343046
   
  
• Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations.
  Peng GS, Yin SJ
  Hum Genomics. 2009
  PubMed ID: 19164089
   
  
• Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach.
  Boccia S, Hashibe M, Gallì P, De Feo E, Asakage T, Hashimoto T, Hiraki A, Katoh T, Nomura T, Yokoyama A, van Duijn CM, Ricciardi G, Boffetta P
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19124505
   
  
• Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese.
  Kanda J, Matsuo K, Suzuki T, Kawase T, Hiraki A, Watanabe M, Mizuno N, Sawaki A, Yamao K, Tajima K, Tanaka H
  Cancer Sci. 2008
  PubMed ID: 19068087
   
  
• [Correlation analyses of ALDH2 and CYP2E1 genetic polymorphism with personality]
  Ohtsuka Y, Aoki J, Iwahashi K
  Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008
  PubMed ID: 19230487
   
  
• Polymorphisms in mitochondrial genes and prostate cancer risk.
  Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 19064571
   
  
• Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin.
  Beretta M, Sottler A, Schmidt K, Mayer B, Gorren AC
  J Biol Chem. 2008
  PubMed ID: 18786921
   
  
• The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors.
  Husemoen LL, Fenger M, Friedrich N, Tolstrup JS, Beenfeldt Fredriksen S, Linneberg A
  Alcohol Clin Exp Res. 2008
  PubMed ID: 18782342
   
  
• Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction.
  Wenzel P, Schuhmacher S, Kienhöfer J, Müller J, Hortmann M, Oelze M, Schulz E, Treiber N, Kawamoto T, Scharffetter-Kochanek K, Münzel T, Bürkle A, Bachschmid MM, Daiber A
  Cardiovasc Res. 2008
  PubMed ID: 18596060
   
  
• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice.
  Matsumoto A, Kawamoto T, Mutoh F, Isse T, Oyama T, Kitagawa K, Nakayama KI, Ichiba M
  Pharmacogenet Genomics. 2008
  PubMed ID: 18704003
   
  
• Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
  Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
  Carcinogenesis. 2008
  PubMed ID: 18676680
   
  
• Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.
  Eom SY, Zhang YW, Kim SH, Choe KH, Lee KY, Park JD, Hong YC, Kim YD, Kang JW, Kim H
  Cancer Causes Control. 2008
  PubMed ID: 18798003
   
  
• Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.
  Glatt H, Rost K, Frank H, Seidel A, Kollock R
  Arch Biochem Biophys. 2008
  PubMed ID: 18621017
   
  
• Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
  Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D
  Science. 2008
  PubMed ID: 18787169
   
  
• Genetic Contributions to the Development of Retinopathy of Prematurity.
  Mohamed S, Schaa K, Cooper ME, Ahrens E, Alvarado A, Colaizy T, Marazita ML, Murray JC, Dagle JM
  Pediatr Res. 2008
  PubMed ID: 18787502
   
  
• Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism.
  Guo R, Chen XP, Guo X, Chen L, Li D, Peng J, Li YJ
  J Am Coll Cardiol. 2008
  PubMed ID: 18772068
   
  
• Sex differences in environmental and genetic factors for hypertension.
  Ruixing Y, Jinzhen W, Shangling P, Weixiong L, Dezhai Y, Yuming C
  Am J Med. 2008
  PubMed ID: 18724972
   
  
• Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.
  Gao CM, Takezaki T, Wu JZ, Zhang XM, Cao HX, Ding JH, Liu YT, Li SP, Cao J, Matsuo K, Hamajima N, Tajima K
  World J Gastroenterol. 2008
  PubMed ID: 18763293
   
  
• Effects of Functional Polymorphisms Related to Catecholaminergic Systems on Changes in Blood Catecholamine and Cardiovascular Measures After Alcohol Ingestion in the Japanese Population.
  Nishimura FT, Kimura Y, Abe S, Fukunaga T, Minami J, Tanii H, Saijoh K
  Alcohol Clin Exp Res. 2008
  PubMed ID: 18715275
   
  
• [Relationship between susceptibility of formaldehyde metabolism and genetic polymorphisms of ALDH2 and cytochrome P4502E1]
  Cheng XM, Zhao J, Feng B, Wen PE, Shao H
  Zhonghua Yu Fang Yi Xue Za Zhi. 2008
  PubMed ID: 19115622
   
  
• Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan.
  Wada M, Daimon M, Emi M, Iijima H, Sato H, Koyano S, Tajima K, Kawanami T, Kurita K, Hunt SC, Hopkins PN, Kubota I, Kawata S, Kato T
  J Atheroscler Thromb. 2008
  PubMed ID: 18776700
   
  
• Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease.
  Kim N, Park YS, Cho SI, Lee HS, Choe G, Kim IW, Won YD, Park JH, Kim JS, Jung HC, Song IS
  Helicobacter. 2008
  PubMed ID: 18665932
   
  
• Effect of aldehyde dehydrogenase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion.
  Akamatsu Y, Hayashi T, Sakane N, Moritani T
  Alcohol Clin Exp Res. 2008
  PubMed ID: 18540919
   
  
• A mitochondrial protein compendium elucidates complex I disease biology.
  Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
  Cell. 2008
  PubMed ID: 18614015
   
  
• Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins.
  Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T
  FASEB J. 2008
  PubMed ID: 18272654
   
  
• Salivary Acetaldehyde Concentration According to Alcoholic Beverage Consumed and Aldehyde Dehydrogenase-2 Genotype.
  Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Mizukami T, Yokoyama T
  Alcohol Clin Exp Res. 2008
  PubMed ID: 18616675
   
  
• Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases.
  Beretta M, Gruber K, Kollau A, Russwurm M, Koesling D, Goessler W, Keung WM, Schmidt K, Mayer B
  J Biol Chem. 2008
  PubMed ID: 18450747
   
  
• Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.
  Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S
  J Neurosci. 2008
  PubMed ID: 18550766
   
  
• The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan.
  Wu CY, Wu YS, Lee JF, Huang SY, Yu L, Ko HC, Lu RB
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 17948892
   
  
• Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population.
  Ikeda S, Sasazuki S, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Ohnami S, Sakamoto H, Yoshida T, Iwasaki M, Tsugane S
  Am J Gastroenterol. 2008
  PubMed ID: 18510611
   
  
• Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study.
  Yokoyama A, Omori T, Yokoyama T, Sato Y, Kawakubo H, Maruyama K
  Cancer Sci. 2008
  PubMed ID: 18429959
   
  
• The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese.
  Wang B, Wang J, Zhou S, Tan S, He X, Yang Z, Xie YC, Li S, Zheng C, Ma X
  J Neurol Sci. 2008
  PubMed ID: 18201725
   
  
• Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample.
  Kuo PH, Kalsi G, Prescott CA, Hodgkinson CA, Goldman D, van den Oord EJ, Alexander J, Jiang C, Sullivan PF, Patterson DG, Walsh D, Kendler KS, Riley BP
  Alcohol Clin Exp Res. 2008
  PubMed ID: 18331377
   
  
• [Molecular genetics of alcohol dependence]
  Ujike H
  Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008
  PubMed ID: 18516948
   
  
• Major genetic components underlying alcoholism in Korean population.
  Kim DJ, Choi IG, Park BL, Lee BC, Ham BJ, Yoon S, Bae JS, Cheong HS, Shin HD
  Hum Mol Genet. 2008
  PubMed ID: 18056758
   
  
• Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid.
  Lee CH, Lee JM, Wu DC, Goan YG, Chou SH, Wu IC, Kao EL, Chan TF, Huang MC, Chen PS, Lee CY, Huang CT, Huang HL, Hu CY, Hung YH, Wu MT
  Int J Cancer. 2008
  PubMed ID: 18033686
   
  
• Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males.
  Guo YM, Wang Q, Liu YZ, Chen HM, Qi Z, Guo QH
  World J Gastroenterol. 2008
  PubMed ID: 18322963
   
  
• Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach.
  Chen L, Davey Smith G, Harbord RM, Lewis SJ
  PLoS Med. 2008
  PubMed ID: 18318597
   
  
• SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan.
  Shimosegawa T, Kume K, Masamune A
  J Gastroenterol Hepatol. 2008
  PubMed ID: 18336671
   
  
• Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans.
  Duranceaux NC, Schuckit MA, Luczak SE, Eng MY, Carr LG, Wall TL
  J Stud Alcohol Drugs. 2008
  PubMed ID: 18299763
   
  
• Association of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes with fasting plasma glucose levels in Japanese male and female workers.
  Dakeishi M, Murata K, Sasaki M, Tamura A, Iwata T
  Alcohol Alcohol. 2008
  PubMed ID: 18216179
   
  
• Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department.
  Tseng YM, Jin YR, Chen IJ, Huang FD, Wu SH, Ma H, Chen SY, Tsai LY, Tsai SM, Lee JH
  Clin Chim Acta. 2008
  PubMed ID: 18078815
   
  
• ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties.
  Wenzel P, Müller J, Zurmeyer S, Schuhmacher S, Schulz E, Oelze M, Pautz A, Kawamoto T, Wojnowski L, Kleinert H, Münzel T, Daiber A
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18157936
   
  
• Estimation of single-nucleotide polymorphism allele frequency by alternately binding probe competitive polymerase chain reaction.
  Noda N, Tani H, Morita N, Kurata S, Nakamura K, Kanagawa T, Tsuneda S, Sekiguchi Y
  Anal Chim Acta. 2008
  PubMed ID: 18215653
   
  
• A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers.
  Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland LB, Canzian F, Haugen A
  Carcinogenesis. 2008
  PubMed ID: 18258609
   
  
• A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry.
  Teeguarden JG, Bogdanffy MS, Covington TR, Tan C, Jarabek AM
  Inhal Toxicol. 2008
  PubMed ID: 18302046
   
  
• Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.
  Kitahara K, Kawa S, Katsuyama Y, Umemura T, Ozaki Y, Takayama M, Arakura N, Ota M
  Dis Markers. 2008
  PubMed ID: 19096130
   
  
• Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.
  Hara K, Suyama K, Itoh H, Nagashima S
  Drug Metab Pharmacokinet. 2008
  PubMed ID: 18974607
   
  
• Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals.
  Cichoz-Lach H, Celiński K, Słomka M
  HPB (Oxford). 2008
  PubMed ID: 18773092
   
  
• Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a chinese population.
  Ding J, Li S, Wu J, Gao C, Zhou J, Cao H, Su PS, Liu Y, Zhou X, Chang J
  Asian Pac J Cancer Prev. 2008
  PubMed ID: 18439068
   
  
• Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs).
  Nose J, Saito A, Kamatani N
  J Hum Genet. 2008
  PubMed ID: 18317873
   
  
• Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer.
  Li DP, Dandara C, Walther G, Parker MI
  Clin Chem Lab Med. 2008
  PubMed ID: 18254707
   
  
• Single-dose ethanol administration downregulates expression of cytochrome p450 2E1 mRNA in aldehyde dehydrogenase 2 knockout mice.
  Matsumoto A, Kawamoto T, Horita M, Takahashi T, Isse T, Oyama T, Ichiba M
  Alcohol. 2007
  PubMed ID: 17980998
   
  
• Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China.
  Yang SJ, Wang HY, Li XQ, Du HZ, Zheng CJ, Chen HG, Mu XY, Yang CX
  World J Gastroenterol. 2007
  PubMed ID: 17963305
   
  
• The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu > Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese.
  Xu F, Chen YG, Geng YJ, Zhang H, Jiang CX, Sun Y, Li RJ, Sagar MB, Xue L, Zhang Y
  Tohoku J Exp Med. 2007
  PubMed ID: 17984618
   
  
• Single nucleotide polymorphisms of the ALDH2 gene in six Indian populations.
  Bhaskar LV, Thangaraj K, Osier M, Reddy AG, Rao AP, Singh L, Rao VR
  Ann Hum Biol. 2007
  PubMed ID: 17952709
   
  
• Real-time PCR genotyping of aldehyde dehydrogenase-2 using displacing probes.
  Gu Y, Li Q
  Clin Biochem. 2007
  PubMed ID: 17854793
   
  
• Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland.
  Zhang FF, Hou L, Terry MB, Lissowska J, Morabia A, Chen J, Yeager M, Zatonski W, Chanock S, Chow WH
  Int J Cancer. 2007
  PubMed ID: 17631643
   
  
• Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.
  Peng GS, Chen YC, Tsao TP, Wang MF, Yin SJ
  Pharmacogenet Genomics. 2007
  PubMed ID: 17885622
   
  
• Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population.
  Fischer M, Wetherill LF, Carr LG, You M, Crabb DW
  Alcohol Clin Exp Res. 2007
  PubMed ID: 17850643
   
  
• Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers.
  Hsieh HI, Chen PC, Wong RH, Wang JD, Yang PM, Cheng TJ
  Toxicology. 2007
  PubMed ID: 17659824
   
  
• Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men.
  Yokoyama A, Tsutsumi E, Imazeki H, Suwa Y, Nakamura C, Yokoyama T
  Int J Cancer. 2007
  PubMed ID: 17471563
   
  
• The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer.
  Jelski W, Chrostek L, Szmitkowski M
  Pancreas. 2007
  PubMed ID: 17632320
   
  
• Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study.
  Yin G, Kono S, Toyomura K, Moore MA, Nagano J, Mizoue T, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N
  Cancer Sci. 2007
  PubMed ID: 17517051
   
  
• Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population.
  Minegishi Y, Tsukino H, Muto M, Goto K, Gemma A, Tsugane S, Kudoh S, Nishiwaki Y, Esumi H
  Cancer. 2007
  PubMed ID: 17559142
   
  
• Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption.
  Hui P, Nakayama T, Morita A, Sato N, Hishiki M, Saito K, Yoshikawa Y, Tamura M, Sato I, Takahashi T, Soma M, Izumi Y, Ozawa Y, Cheng Z
  Hypertens Res. 2007
  PubMed ID: 17785925
   
  
• Gene-gene and gene-environment interactions between alcohol drinking habit and polymorphisms in alcohol-metabolizing enzyme genes and the risk of head and neck cancer in Japan.
  Hiraki A, Matsuo K, Wakai K, Suzuki T, Hasegawa Y, Tajima K
  Cancer Sci. 2007
  PubMed ID: 17489985
   
  
• A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men.
  Jo SA, Kim EK, Park MH, Han C, Park HY, Jang Y, Song BJ, Jo I
  Clin Chim Acta. 2007
  PubMed ID: 17459359
   
  
• The role of acetaldehyde in upper digestive tract cancer in alcoholics.
  Seitz HK, Meier P
  Transl Res. 2007
  PubMed ID: 17543846
   
  
• Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation.
  Szöcs K, Lassègue B, Wenzel P, Wendt M, Daiber A, Oelze M, Meinertz T, Münzel T, Baldus S
  J Mol Cell Cardiol. 2007
  PubMed ID: 17493633
   
  
• Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese.
  Matsuo K, Hiraki A, Hirose K, Ito H, Suzuki T, Wakai K, Tajima K
  Hum Mutat. 2007
  PubMed ID: 17285601
   
  
• Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals.
  Cichoz-Lach H, Partycka J, Nesina I, Celinski K, Slomka M, Wojcierowski J
  Scand J Gastroenterol. 2007
  PubMed ID: 17454860
   
  
• A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study.
  Nagasawa H, Wada M, Arawaka S, Kawanami T, Kurita K, Daimon M, Adachi M, Hosoya T, Emi M, Muramatsu M, Kato T
  Eur J Neurol. 2007
  PubMed ID: 17388993
   
  
• Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
  Asakage T, Yokoyama A, Haneda T, Yamazaki M, Muto M, Yokoyama T, Kato H, Igaki H, Tsujinaka T, Kumagai Y, Yokoyama M, Omori T, Watanabe H
  Carcinogenesis. 2007
  PubMed ID: 17071628
   
  
• p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma.
  Yokoyama A, Omori T, Tanaka Y, Yokoyama T, Sugiura H, Mizukami T, Matsushita S, Higuchi S, Maruyama K, Ishii H, Hibi T
  Cancer Lett. 2007
  PubMed ID: 16759795
   
  
• Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department.
  Tseng YM, Hu BW, Tsai SM, Chen IJ, Jin YR, Lee JH, Huang FD, Wu SH, Yeh FL, Tsai LY
  Clin Biochem. 2007
  PubMed ID: 17292341
   
  
• Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms.
  Ishikawa H, Ishikawa T, Yamamoto H, Fukao A, Yokoyama K
  Mutat Res. 2007
  PubMed ID: 17207821
   
  
• Lack of aldehyde dehydrogenase ameliorates oxidative stress induced by single-dose ethanol administration in mouse liver.
  Matsumoto A, Ichiba M, Horita M, Yamashita Z, Takahashi T, Isse T, Oyama T, Kawamoto T, Tomokuni K
  Alcohol. 2007
  PubMed ID: 17452299
   
  
• Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients.
  Sasabe T, Furukawa A, Matsusita S, Higuchi S, Ishiura S
  Neurosci Lett. 2007
  PubMed ID: 17196743
   
  
• Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance.
  Wenzel P, Hink U, Oelze M, Schuppan S, Schaeuble K, Schildknecht S, Ho KK, Weiner H, Bachschmid M, Münzel T, Daiber A
  J Biol Chem. 2007
  PubMed ID: 17102135
   
  
• The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk.
  Schindler J, Li Y, Marion MJ, Paroly A, Brandt-Rauf PW
  J Hum Genet. 2007
  PubMed ID: 17384900
   
  
• Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks.
  Chen YJ, Chen C, Wu DC, Lee CH, Wu CI, Lee JM, Goan YG, Huang SP, Lin CC, Li TC, Chou YP, Wu MT
  Int J Cancer. 2006
  PubMed ID: 17036331
   
  
• Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells.
  Xu D, Guthrie JR, Mabry S, Sack TM, Truog WE
  Am J Physiol Lung Cell Mol Physiol. 2006
  PubMed ID: 16782756
   
  
• Increased DNA damage in ALDH2-deficient alcoholics.
  Matsuda T, Yabushita H, Kanaly RA, Shibutani S, Yokoyama A
  Chem Res Toxicol. 2006
  PubMed ID: 17040107
   
  
• Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice.
  Bhave SV, Hoffman PL, Lassen N, Vasiliou V, Saba L, Deitrich RA, Tabakoff B
  Alcohol Clin Exp Res. 2006
  PubMed ID: 17010133
   
  
• Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice.
  Fernandez E, Koek W, Ran Q, Gerhardt GA, France CP, Strong R
  Alcohol Clin Exp Res. 2006
  PubMed ID: 17010132
   
  
• SPINK1 gene mutations and pancreatitis in Japan.
  Shimosegawa T, Kume K, Masamune A
  J Gastroenterol Hepatol. 2006
  PubMed ID: 16958672
   
  
• Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women.
  Lorenzo A, Auguet T, Vidal F, Broch M, Olona M, Gutiérrez C, López-Dupla M, Sirvent JJ, Quer JC, Santos M, Richart C
  Drug Alcohol Depend. 2006
  PubMed ID: 16600530
   
  
• Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
  Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
  Mol Cell. 2006
  PubMed ID: 16916647
   
  
• Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men.
  Naito H, Yamanoshita O, Kamijima M, Katoh T, Matsunaga T, Lee CH, Kim H, Aoyama T, Gonzalez FJ, Nakajima T
  Pharmacogenet Genomics. 2006
  PubMed ID: 16847426
   
  
• Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians.
  Luczak SE, Glatt SJ, Wall TL
  Psychol Bull. 2006
  PubMed ID: 16822169
   
  
• Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans.
  Dickson PA, James MR, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Birley AJ
  Alcohol Clin Exp Res. 2006
  PubMed ID: 16792555
   
  
• Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder.
  Kim JW, Park CS, Hwang JW, Shin MS, Hong KE, Cho SC, Kim BN
  Alcohol Alcohol. 2006
  PubMed ID: 16679343
   
  
• ALDH2 promoter polymorphism has no effect on the risk for alcoholism.
  Kimura M, Kimura S, Matsushita S, Kashima H, Higuchi S
  Alcohol Alcohol. 2006
  PubMed ID: 16624836
   
  
• Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population.
  Montano Loza AJ, Ramirez Iglesias MT, Perez Diaz I, Cruz Castellanos S, Garcia Andrade C, Medina Mora ME, Robles Díaz G, Kershenobich D, Gutierrez Reyes G
  Alcohol. 2006
  PubMed ID: 17134659
   
  
• Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.
  Luo X, Kranzler HR, Zuo L, Wang S, Schork NJ, Gelernter J
  Am J Hum Genet. 2006
  PubMed ID: 16685648
   
  
• Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma.
  Cai L, You NC, Lu H, Mu LN, Lu QY, Yu SZ, Le AD, Marshall J, Heber D, Zhang ZF
  Cancer. 2006
  PubMed ID: 16639733
   
  
• Application of aldehyde dehydrogenase 2 (ALDH2) genetic diagnosis in support of decreasing alcohol intake.
  Komiya Y, Nakao H, Kuroda Y, Arizono K, Nakahara A, Katoh T
  J Occup Health. 2006
  PubMed ID: 16788276
   
  
• Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects.
  Matsuo K, Wakai K, Hirose K, Ito H, Saito T, Tajima K
  Cancer Epidemiol Biomarkers Prev. 2006
  PubMed ID: 16702384
   
  
• ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college students.
  Luczak SE, Shea SH, Hsueh AC, Chang J, Carr LG, Wall TL
  J Stud Alcohol. 2006
  PubMed ID: 16608143
   
  
• A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan.
  Matsuo K, Wakai K, Hirose K, Ito H, Saito T, Suzuki T, Kato T, Hirai T, Kanemitsu Y, Hamajima H, Tajima K
  Carcinogenesis. 2006
  PubMed ID: 16332725
   
  
• Effect of -361 G/A polymorphism of aldehyde dehydrogenase-2 gene on alcohol metabolism and its expression in human peripheral blood leukocytes.
  Nishimura FT, Kimura Y, Abe S, Fukunaga T, Saijoh K
  Nihon Arukoru Yakubutsu Igakkai Zasshi. 2006
  PubMed ID: 16734278
   
  
• ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double-blind placebo-controlled crossover study.
  Shin HY, Shin IS, Yoon JS
  Hum Psychopharmacol. 2006
  PubMed ID: 16565959
   
  
• The finished DNA sequence of human chromosome 12.
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  Nature. 2006
  PubMed ID: 16541075
   
  
• Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular carcinoma in a Japanese population.
  Sakamoto T, Hara M, Higaki Y, Ichiba M, Horita M, Mizuta T, Eguchi Y, Yasutake T, Ozaki I, Yamamoto K, Onohara S, Kawazoe S, Shigematsu H, Koizumi S, Tanaka K
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  PubMed ID: 16187278
   
  
• [Polymorphisms of aldehyde and alcohol dehydrogenase genes associated with susceptibility to trichloroethylene-induced medicamentosa-like dermatitis]
  Li HS, Dai YF, Huang HL, Sun YF
  Wei Sheng Yan Jiu. 2006
  PubMed ID: 16758956
   
  
• Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females.
  Yokoyama A, Kato H, Yokoyama T, Igaki H, Tsujinaka T, Muto M, Omori T, Kumagai Y, Yokoyama M, Watanabe H
  Alcohol Clin Exp Res. 2006
  PubMed ID: 16499490
   
  
• Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes.
  Ishikawa H, Miyatsu Y, Kurihara K, Yokoyama K
  Mutat Res. 2006
  PubMed ID: 16126235
   
  
• Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?
  Zintzaras E, Stefanidis I, Santos M, Vidal F
  Hepatology. 2006
  PubMed ID: 16440362
   
  
• Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.
  Li Y, Zhang D, Jin W, Shao C, Yan P, Xu C, Sheng H, Liu Y, Yu J, Xie Y, Zhao Y, Lu D, Nebert DW, Harrison DC, Huang W, Jin L
  J Clin Invest. 2006
  PubMed ID: 16440063
   
  
• Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development.
  Yoon M, Madden MC, Barton HA
  Toxicol Sci. 2006
  PubMed ID: 16291827
   
  
• Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism.
  Choi IG, Kee BS, Son HG, Ham BJ, Yang BH, Kim SH, Lee JS, Son BK, Lee BY, Lee SY, Chai YG, Shin HD
  Eur Neuropsychopharmacol. 2006
  PubMed ID: 16125912
   
  
• ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma.
  Hashimoto T, Uchida K, Okayama N, Imate Y, Suehiro Y, Ueyama Y, Yamashita H, Hinoda Y
  Tumour Biol. 2006
  PubMed ID: 17033202
   
  
• Association of micro-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population.
  Nishizawa D, Han W, Hasegawa J, Ishida T, Numata Y, Sato T, Kawai A, Ikeda K
  Neuropsychobiology. 2006
  PubMed ID: 16679777
   
  
• ALDH2 polymorphisms and bone mineral density in an elderly Japanese population.
  Yamaguchi J, Hasegawa Y, Kawasaki M, Masui T, Kanoh T, Ishiguro N, Hamajima N
  Osteoporos Int. 2006
  PubMed ID: 16520888
   
  
• ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers.
  Yamada Y, Imai T, Ishizaki M, Honda R
  J Hum Genet. 2006
  PubMed ID: 16365683
   
  
• Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action.
  Wall TL
  Ther Drug Monit. 2005
  PubMed ID: 16404797
   
  
• Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice.
  Isse T, Oyama T, Matsuno K, Ogawa M, Narai-Suzuki R, Yamaguchi T, Murakami T, Kinaga T, Uchiyama I, Kawamoto T
  J Toxicol Sci. 2005
  PubMed ID: 16404141
   
  
• Aldehyde dehydrogenase 2 activity affects symptoms produced by an intraperitoneal acetaldehyde injection, but not acetaldehyde lethality.
  Isse T, Oyama T, Matsuno K, Uchiyama I, Kawamoto T
  J Toxicol Sci. 2005
  PubMed ID: 16404140
   
  
• No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan.
  Lu RB, Ko HC, Lee JF, Lin WW, Huang SY, Wang TJ, Wu YS, Lu TE, Chou YH
  Alcohol Clin Exp Res. 2005
  PubMed ID: 16385179
   
  
• Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle.
  Ishikawa N, Murata C, Mikurube H, Ito S, Higashiyama R, Komaki Y, Atsumi Y, Matsuoka K, Watanabe T
  Nippon Koshu Eisei Zasshi. 2005
  PubMed ID: 16408483
   
  
• [Genetic susceptibility to the development of acute alcoholic hepatitis: role of genetic mutations in dehydrogenase alcohol, aldehyde dehydrogenase and cytochrome P450 2E1]
  Segado Soriano A, Santiago Dorrego C, Bañares Cañizares R, Alvarez Fernández E, Bandrés Moya F, Gómez-Gallego F
  Rev Clin Esp. 2005
  PubMed ID: 16324524
   
  
• Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer's disease.
  Shin IS, Stewart R, Kim JM, Kim SW, Yang SJ, Shin HY, Jung JS, Yoon JS
  Int J Geriatr Psychiatry. 2005
  PubMed ID: 16250071
   
  
• Certain background factors exhibit an association with an increased risk for pancreatic calcification among Japanese male alcoholics.
  Nakamura Y, Ohmori T, Higuchi S, Maruyama K
  Pancreas. 2005
  PubMed ID: 16163053
   
  
• A human protein-protein interaction network: a resource for annotating the proteome.
  Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
  Cell. 2005
  PubMed ID: 16169070
   
  
• Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males.
  Wu CF, Wu DC, Hsu HK, Kao EL, Lee JM, Lin CC, Wu MT
  World J Gastroenterol. 2005
  PubMed ID: 16127737
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase "Asian" variant.
  Larson HN, Weiner H, Hurley TD
  J Biol Chem. 2005
  PubMed ID: 15983043
   
  
• An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.
  Chen Z, Foster MW, Zhang J, Mao L, Rockman HA, Kawamoto T, Kitagawa K, Nakayama KI, Hess DT, Stamler JS
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16103363
   
  
• Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study.
  Hirose M, Kono S, Tabata S, Ogawa S, Yamaguchi K, Mineshita M, Hagiwara T, Yin G, Lee KY, Tsuji A, Ikeda N
  Cancer Sci. 2005
  PubMed ID: 16108833
   
  
• Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach.
  Lewis SJ, Smith GD
  Cancer Epidemiol Biomarkers Prev. 2005
  PubMed ID: 16103445
   
  
• A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.
  Landi S, Gemignani F, Moreno V, Gioia-Patricola L, Chabrier A, Guino E, Navarro M, de Oca J, Capellà G, Canzian F, Bellvitge Colorectal Cancer Study Group
  Pharmacogenet Genomics. 2005
  PubMed ID: 16006997
   
  
• Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer.
  Nan HM, Song YJ, Yun HY, Park JS, Kim H
  World J Gastroenterol. 2005
  PubMed ID: 15991278
   
  
• Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions.
  Yang CX, Matsuo K, Ito H, Hirose K, Wakai K, Saito T, Shinoda M, Hatooka S, Mizutani K, Tajima K
  Asian Pac J Cancer Prev. 2005
  PubMed ID: 16235983
   
  
• Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men.
  Yokoyama A, Omori T, Yokoyama T, Tanaka Y, Mizukami T, Matsushita S, Higuchi S, Takahashi H, Maruyama K, Ishii H, Hibi T
  J Gastroenterol. 2005
  PubMed ID: 16082583
   
  
• Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers.
  Yokoyama M, Yokoyama A, Yokoyama T, Funazu K, Hamana G, Kondo S, Yamashita T, Nakamura H
  Alcohol Clin Exp Res. 2005
  PubMed ID: 16046871
   
  
• Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake.
  Kim JS, Kim YJ, Kim TY, Song JY, Cho YH, Park YC, Chung HW
  Toxicology. 2005
  PubMed ID: 15840430
   
  
• Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism.
  Chai YG, Oh DY, Chung EK, Kim GS, Kim L, Lee YS, Choi IG
  Am J Psychiatry. 2005
  PubMed ID: 15863807
   
  
• Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2.
  Lassen N, Estey T, Tanguay RL, Pappa A, Reimers MJ, Vasiliou V
  Drug Metab Dispos. 2005
  PubMed ID: 15703303
   
  
• Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study.
  Kim YD, Oyama T, Isse T, Kim H, Kawamoto T
  Arch Toxicol. 2005
  PubMed ID: 15654606
   
  
• ALDH2 genotype is associated in the relation between alcohol intake and periodontitis.
  Merchant AT
  J Evid Based Dent Pract. 2005
  PubMed ID: 17138329
   
  
• Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans.
  Cook TA, Luczak SE, Shea SH, Ehlers CL, Carr LG, Wall TL
  J Stud Alcohol. 2005
  PubMed ID: 15957670
   
  
• Psychosocial, cultural and genetic influences on alcohol use in Asian American youth.
  Hendershot CS, MacPherson L, Myers MG, Carr LG, Wall TL
  J Stud Alcohol. 2005
  PubMed ID: 15957669
   
  
• [Polymorphism of alcohol metabolizing-related enzyme genes and its correlation with drinking-behaviors in 201 cases of Chinese Han healthy population.]
  Cao XR, Wu DS
  Zhonghua Yu Fang Yi Xue Za Zhi. 2005
  PubMed ID: 15842823
   
  
• Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population.
  Miyasaka K, Kawanami T, Shimokata H, Ohta S, Funakoshi A
  Pancreas. 2005
  PubMed ID: 15714130
   
  
• Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population.
  You WC, Hong JY, Zhang L, Pan KF, Pee D, Li JY, Ma JL, Rothman N, Caporaso N, Fraumeni JF, Xu GW, Gail MH
  Cancer Epidemiol Biomarkers Prev. 2005
  PubMed ID: 15734972
   
  
• Alcohol drinking frequency is more directly associated with alcohol use disorder than alcohol metabolizing enzymes among male Japanese.
  Nishiyori A, Shibata A, Ogimoto I, Uchimura N, Egami H, Nakamura J, Sakata R, Fukuda K
  Psychiatry Clin Neurosci. 2005
  PubMed ID: 15679538
   
  
• Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide.
  Kollau A, Hofer A, Russwurm M, Koesling D, Keung WM, Schmidt K, Brunner F, Mayer B
  Biochem J. 2005
  PubMed ID: 15377279
   
  
• Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan.
  Otani T, Iwasaki M, Hanaoka T, Kobayashi M, Ishihara J, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Yoshimura K, Yoshida T, Tsugane S
  Nutr Cancer. 2005
  PubMed ID: 16351505
   
  
• Rapid, accurate genotyping of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 based on the use of denaturing HPLC.
  Li L, Mo QH, Xu XM
  Clin Chem Lab Med. 2005
  PubMed ID: 16309369
   
  
• [Alcohol-induced arterial hypertension and genetic polymorphism of alcohol-metabolizing enzymes]
  Moiseev VS, Ogurtsov PP, Kobalova ZhD, Ovchinnikov NS, Garmash IV, Mazurchik NV, Shipulin GA
  Ter Arkh. 2005
  PubMed ID: 16078602
   
  
• Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit.
  Kuriki K, Hamajima N, Chiba H, Kanemitsu Y, Hirai T, Kato T, Saito T, Matsuo K, Koike K, Tokudome S, Tajima K
  Asian Pac J Cancer Prev. 2005
  PubMed ID: 15780035
   
  
• Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples.
  Liu Y, Yoshimura K, Hanaoka T, Ohnami S, Ohnami S, Kohno T, Yoshida T, Sakamoto H, Sobue T, Tsugane S
  J Hum Genet. 2005
  PubMed ID: 15654505
   
  
• Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism.
  Oyama T, Isse T, Kagawa N, Kinaga T, Kim YD, Morita M, Sugio K, Weiner H, Yasumoto K, Kawamoto T
  Front Biosci. 2005
  PubMed ID: 15569633
   
  
• Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
  Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
  Nat Methods. 2004
  PubMed ID: 15782199
   
  
• Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease.
  Vidal F, Lorenzo A, Auguet T, Olona M, Broch M, Gutiérrez C, Aguilar C, Estupiñà P, Santos M, Richart C
  J Hepatol. 2004
  PubMed ID: 15519646
   
  
• Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
  Aboulaich N, Vainonen JP, Strålfors P, Vener AV
  Biochem J. 2004
  PubMed ID: 15242332
   
  
• Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients.
  Kim SA, Kim JW, Song JY, Park S, Lee HJ, Chung JH
  Alcohol. 2004
  PubMed ID: 15902904
   
  
• Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders.
  Higuchi S, Matsushita S, Masaki T, Yokoyama A, Kimura M, Suzuki G, Mochizuki H
  Ann N Y Acad Sci. 2004
  PubMed ID: 15542751
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison.
  Sepehr A, Kamangar F, Abnet CC, Fahimi S, Pourshams A, Poustchi H, Zeinali S, Sotoudeh M, Islami F, Nasrollahzadeh D, Malekzadeh R, Taylor PR, Dawsey SM
  Cancer Lett. 2004
  PubMed ID: 15327835
   
  
• Relation of genotypes of alcohol metabolizing enzymes and mortality of liver diseases in patients with alcohol dependence.
  Chen CC, Kuo CJ, Tsai SY, Yin SJ
  Addict Biol. 2004
  PubMed ID: 15511718
   
  
• ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles.
  Konishi T, Luo HR, Calvillo M, Mayo MS, Lin KM, Wan YJ
  Alcohol Clin Exp Res. 2004
  PubMed ID: 15318112
   
  
• Comparative analyses of four different methods of genotyping ALDH2.
  Itoga S, Nanmoku T, Uchimoto T, Sunaga M, Nezu M, Tomonaga T, Harada S, Nomura F
  Alcohol Clin Exp Res. 2004
  PubMed ID: 15318097
   
  
• ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes.
  Suzuki Y, Taniyama M, Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K
  Alcohol Clin Exp Res. 2004
  PubMed ID: 15318096
   
  
• Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans.
  Masaki T, Mochizuki H, Matsushita S, Yokoyama A, Kamakura K, Higuchi S
  Neurosci Lett. 2004
  PubMed ID: 15182962
   
  
• [Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]
  Kim MS, Lee DH, Kang HS, Park HS, Jung S, Lee JW, Kwon KS, Kim PS, Kim HG, Shin YW, Kim YS, Baek I, Lee MS
  Korean J Gastroenterol. 2004
  PubMed ID: 15220553
   
  
• Genetic analysis of 22 candidate genes for hypertension in the Japanese population.
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  J Hypertens. 2004
  PubMed ID: 15167446
   
  
• Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital.
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  Nagoya J Med Sci. 2004
  PubMed ID: 15279067
   
  
• ALDH2 status and conduct disorder mediate the relationship between ethnicity and alcohol dependence in Chinese, Korean, and White American college students.
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  J Abnorm Psychol. 2004
  PubMed ID: 15122947
   
  
• Mitochondrial ALDH2 deficiency as an oxidative stress.
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  Ann N Y Acad Sci. 2004
  PubMed ID: 15126281
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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  Nature. 2004
  PubMed ID: 15057822
   
  
• Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
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  Neurobiol Aging. 2004
  PubMed ID: 15123334
   
  
• Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence.
  Huang SY, Lin WW, Ko HC, Lee JF, Wang TJ, Chou YH, Yin SJ, Lu RB
  Alcohol Clin Exp Res. 2004
  PubMed ID: 15084894
   
  
• The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination.
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  Ann Hum Genet. 2004
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• Association of ALDH(2) genotypes and alcohol consumption with periodontitis.
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  J Dent Res. 2004
  PubMed ID: 14742656
   
  
• Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review.
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  Am J Epidemiol. 2004
  PubMed ID: 14693654
   
  
• Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter.
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  Alcohol Clin Exp Res. 2003
  PubMed ID: 14691372
   
  
• Brain mitochondrial aldehyde dehydrogenase: relation to acetaldehyde aversion in low-alcohol-drinking (UChA) and high-alcohol-drinking (UChB) rats.
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  Addict Biol. 2003
  PubMed ID: 14690875
   
  
• Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
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  Cell. 2003
  PubMed ID: 14651853
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Expression of the aldehyde dehydrogenase 2-like gene is controlled by BOB.1/OBF.1 in B lymphocytes.
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  J Biol Chem. 2003
  PubMed ID: 12947107
   
  
• Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers.
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  Mutat Res. 2003
  PubMed ID: 14568296
   
  
• Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men.
  Yokoyama T, Yokoyama A, Kato H, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Yoshimizu H
  Cancer Epidemiol Biomarkers Prev. 2003
  PubMed ID: 14652286
   
  
• [Relationship between ALDH gene polymorphism and alcoholic liver diseases]
  Yan M, Zhu KX, Meng FL, Wang HJ, Wu ML
  Zhonghua Gan Zang Bing Za Zhi. 2003
  PubMed ID: 14636437
   
  
• Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis.
  Narita M, Kitagawa K, Nagai Y, Hougaku H, Hashimoto H, Sakaguchi M, Yang X, Takeshita T, Morimoto K, Matsumoto M, Hori M
  Ultrasound Med Biol. 2003
  PubMed ID: 14597338
   
  
• Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome.
  Murata C, Watanabe T, Furuya H, Sugioka Y, Mikurube H, Yokoyama A, Atsumi Y, Matsuoka K, Okazaki I
  Metabolism. 2003
  PubMed ID: 14506613
   
  
• Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers.
  Yokoyama M, Yokoyama A, Yokoyama T, Hamana G, Funazu K, Kondo S, Yamashita T, Yoshimizu H, Nakamura H
  Alcohol Clin Exp Res. 2003
  PubMed ID: 14506399
   
  
• Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver.
  Chao YC, Wang SJ, Chu HC, Chang WK, Hsieh TY
  Alcohol Alcohol. 2003
  PubMed ID: 12915519
   
  
• Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase beta subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2).
  Tamakoshi A, Hamajima N, Kawase H, Wakai K, Katsuda N, Saito T, Ito H, Hirose K, Takezaki T, Tajima K
  Alcohol Alcohol. 2003
  PubMed ID: 12915514
   
  
• Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population.
  Mulligan CJ, Robin RW, Osier MV, Sambuughin N, Goldfarb LG, Kittles RA, Hesselbrock D, Goldman D, Long JC
  Hum Genet. 2003
  PubMed ID: 12884000
   
  
• A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
  Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12904583
   
  
• Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism.
  Kato S, Tajiri T, Matsukura N, Matsuda N, Taniai N, Mamada H, Yoshida H, Kiyam T, Naito Z
  Scand J Gastroenterol. 2003
  PubMed ID: 12940444
   
  
• Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats.
  Sapag A, Tampier L, Valle-Prieto A, Quintanilla ME, Moncada C, Israel Y
  Pharmacogenetics. 2003
  PubMed ID: 12893989
   
  
• XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers.
  Wong RH, Wang JD, Hsieh LL, Cheng TJ
  Arch Toxicol. 2003
  PubMed ID: 12739102
   
  
• Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase.
  Perez-Miller SJ, Hurley TD
  Biochemistry. 2003
  PubMed ID: 12795606
   
  
• [Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]
  Kee JY, Kim MO, You IY, Chai JY, Hong ES, An SC, Kim H, Park SM, Youn SJ, Chae HB
  Taehan Kan Hakhoe Chi. 2003
  PubMed ID: 12824748
   
  
• Do the ethanol metabolizing enzymes modify the relationship between alcohol consumption and blood pressure?
  Saito K, Yokoyama T, Yoshiike N, Date C, Yamamoto A, Muramatsu M, Tanaka H
  J Hypertens. 2003
  PubMed ID: 12777946
   
  
• Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma.
  Munaka M, Kohshi K, Kawamoto T, Takasawa S, Nagata N, Itoh H, Oda S, Katoh T
  J Cancer Res Clin Oncol. 2003
  PubMed ID: 12759747
   
  
• [Gene-environmental interactions in alcohol-related health problems--contributions of molecular biology to behavior modifications]
  Takeshita T
  Nippon Eiseigaku Zasshi. 2003
  PubMed ID: 12806963
   
  
• Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations.
  Nishimura FT, Fukunaga T, Yokomukai Y, Kajiura H, Ono T, Nishijo H
  Alcohol Clin Exp Res. 2003
  PubMed ID: 12766630
   
  
• Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men.
  Assanangkornchai S, Noi-pha K, Saunders JB, Ratanachaiyavong S
  Psychiatry Res. 2003
  PubMed ID: 12759156
   
  
• Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese.
  Suzuki Y, Kuriyama S, Atsumi Y, Murata C, Matsuoka K, Suzuki Y, Taniyama M, Muramatsu T, Suzuki Y, Ohta S
  Diabetes Res Clin Pract. 2003
  PubMed ID: 12706324
   
  
• Relation among alcohol dehydrogenase 2 polymorphism, alcohol consumption, and levels of gamma-glutamyltransferase.
  Loew M, Boeing H, Stürmer T, Brenner H
  Alcohol. 2003
  PubMed ID: 12798968
   
  
• Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells.
  Ohsawa I, Nishimaki K, Yasuda C, Kamino K, Ohta S
  J Neurochem. 2003
  PubMed ID: 12603834
   
  
• Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development.
  Choi JY, Abel J, Neuhaus T, Ko Y, Harth V, Hamajima N, Tajima K, Yoo KY, Park SK, Noh DY, Han W, Choe KJ, Ahn SH, Kim SU, Hirvonen A, Kang D
  Pharmacogenetics. 2003
  PubMed ID: 12563175
   
  
• Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes and male alcohol use disorders in Khon Kaen, north-east Thailand.
  Osaka R, Nanakorn S, Sakata R, Nishiyori A, Shibata A, Nakamura J, Fukuda K
  Psychiatry Clin Neurosci. 2003
  PubMed ID: 12519453
   
  
• A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head.
  Sakata R
  Kurume Med J. 2003
  PubMed ID: 14768474
   
  
• Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples.
  Yoshimura K, Hanaoka T, Ohnami S, Ohnami S, Kohno T, Liu Y, Yoshida T, Sakamoto H, Tsugane S
  J Hum Genet. 2003
  PubMed ID: 14634838
   
  
• Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females.
  Ohsawa I, Kamino K, Nagasaka K, Ando F, Niino N, Shimokata H, Ohta S
  J Hum Genet. 2003
  PubMed ID: 12905081
   
  
• Polymorphisms for vinyl chloride metabolism in French vinyl chloride workers.
  Li Y, Marion MJ, Ho R, Cheng TJ, Coulibaly D, Rosal R, Brandt-Rauf PW
  Int J Occup Med Environ Health. 2003
  PubMed ID: 12705718
   
  
• Influence of genetic admixture on polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area.
  Konishi T, Smith JL, Lin KM, Wan YJ
  Alcohol Alcohol. 2003
  PubMed ID: 12554615
   
  
• Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians.
  Wall TL, Carr LG, Ehlers CL
  Am J Psychiatry. 2003
  PubMed ID: 12505800
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population.
  Boonyaphiphat P, Thongsuksai P, Sriplung H, Puttawibul P
  Cancer Lett. 2002
  PubMed ID: 12213289
   
  
• Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects.
  Nishimura FT, Fukunaga T, Kajiura H, Umeno K, Takakura H, Ono T, Nishijo H
  Auton Neurosci. 2002
  PubMed ID: 12492137
   
  
• Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes.
  Peng GS, Yin JH, Wang MF, Lee JT, Hsu YD, Yin SJ
  J Formos Med Assoc. 2002
  PubMed ID: 12517056
   
  
• Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population.
  Amamoto K, Okamura T, Tamaki S, Kita Y, Tsujita Y, Kadowaki T, Nakamura Y, Ueshima H
  Hypertens Res. 2002
  PubMed ID: 12484509
   
  
• Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma.
  Yokoyama A, Kato H, Yokoyama T, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Fukuda H, Yoshimizu H
  Carcinogenesis. 2002
  PubMed ID: 12419833
   
  
• Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli.
  Lee KH, Kim HS, Jeong HS, Lee YS
  Biochem Biophys Res Commun. 2002
  PubMed ID: 12387818
   
  
• Altered profile of gene expression in rat hearts induced by chronic nicotine consumption.
  Hu D, Cao K, Peterson-Wakeman R, Wang R
  Biochem Biophys Res Commun. 2002
  PubMed ID: 12359213
   
  
• Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer.
  Muto M, Nakane M, Hitomi Y, Yoshida S, Sasaki S, Ohtsu A, Yoshida S, Ebihara S, Esumi H
  Carcinogenesis. 2002
  PubMed ID: 12376487
   
  
• [Studies of genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang China]
  Zhang ZM, Liu CZ, Bian JC, Tang BM, Jiang F, Wang QJ, Wang QM, Zhu X, Shen FM
  Yi Chuan. 2002
  PubMed ID: 16135443
   
  
• Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men.
  Takagi S, Iwai N, Yamauchi R, Kojima S, Yasuno S, Baba T, Terashima M, Tsutsumi Y, Suzuki S, Morii I, Hanai S, Ono K, Baba S, Tomoike H, Kawamura A, Miyazaki S, Nonogi H, Goto Y
  Hypertens Res. 2002
  PubMed ID: 12452318
   
  
• Alcohol dependence symptoms and alcohol dehydrogenase 2 polymorphism: Israeli Ashkenazis, Sephardics, and recent Russian immigrants.
  Hasin D, Aharonovich E, Liu X, Mamman Z, Matseoane K, Carr And LG, Li TK
  Alcohol Clin Exp Res. 2002
  PubMed ID: 12351924
   
  
• Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers.
  Yokoyama A, Watanabe H, Fukuda H, Haneda T, Kato H, Yokoyama T, Muramatsu T, Igaki H, Tachimori Y
  Cancer Epidemiol Biomarkers Prev. 2002
  PubMed ID: 12223435
   
  
• Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer.
  Watanabe S, Sasahara K, Kinekawa F, Uchida N, Masaki T, Kurokohchi K, Murota M, Touge T, Kawauchi K, Oda S, Kuriyama S
  Oncol Rep. 2002
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• Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels.
  Nakamura Y, Amamoto K, Tamaki S, Okamura T, Tsujita Y, Ueno Y, Kita Y, Kinoshita M, Ueshima H
  Atherosclerosis. 2002
  PubMed ID: 12119207
   
  
• Interaction between alcohol dehydrogenase II gene, alcohol consumption, and risk for breast cancer.
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  Br J Cancer. 2002
  PubMed ID: 12189549
   
  
• Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer.
  Itoga S, Nomura F, Makino Y, Tomonaga T, Shimada H, Ochiai T, Iizasa T, Baba M, Fujisawa T, Harada S
  Alcohol Clin Exp Res. 2002
  PubMed ID: 12198369
   
  
• Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury.
  Nagata N, Hiyoshi M, Shiozawa H, Shiraishi K, Watanabe N, Tsuda M, Matsuzaki S
  Alcohol Clin Exp Res. 2002
  PubMed ID: 12198368
   
  
• Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men.
  Sun F, Tsuritani I, Yamada Y
  Behav Genet. 2002
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• Genotype of ethanol metabolizing enzyme genes by oligonucleotide microarray in alcoholic liver disease in Chinese people.
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  PubMed ID: 12173598
   
  
• The genetics of alcoholism in Polynesians: alcohol and aldehyde dehydrogenase genotypes in young men.
  Chambers GK, Marshall SJ, Robinson GM, Maguire S, Newton-Howes J, Chong NL
  Alcohol Clin Exp Res. 2002
  PubMed ID: 12170102
   
  
• Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption.
  Hashimoto Y, Nakayama T, Futamura A, Omura M, Nakarai H, Nakahara K
  Clin Chem. 2002
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• Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers.
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• [Compare of distributions of gene polymorphisms about alcohol metabolizing-related enzymes in five Chinese nationalities]
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  PubMed ID: 12545748
   
  
• Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients.
  Hamajima N, Saito T, Matsuo K, Suzuki T, Nakamura T, Matsuura A, Okuma K, Tajima K
  J Epidemiol. 2002
  PubMed ID: 12164325
   
  
• Expression of genes for alcohol and aldehyde metabolizing enzymes in mouse oocytes and preimplantation embryos.
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  Reprod Toxicol. 2002
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