EZH2

Summary Top Help

Gene Description:

enhancer of zeste homolog 2 (Drosophila)

Synonyms:

Enx-1, EZH1, ENX-1, Enx1h, mKIAA4065, ENX1, Ezh2, KMT6A, WVS2, KMT6, EZH2

Orthologs:

Human EZH2 (protein-coding), Mouse Ezh2 (protein-coding), Rat Ezh2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 2

Other Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815
Iddm11	Rat	chr4:56920444..78042833	21.12	213

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr7:148504464..148581441 (76.98 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:47480273..47545340 (657 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:75709959..75773279 (63.32 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for EZH2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for EZH2:

The EZH2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
EZH2	CDK6	IntAct	empirical	22094256
EZH2	ZMYND11	HPRD	empirical	16565076
EZH2	CCDC85B	HPRD, MINT, IntAct	empirical	16189514
EZH2	STK38	IntAct, BioGRID	empirical	20064376
EZH2	AEBP2	IntAct, BioGRID	empirical	20064376 20123894
EZH2	CRY1	BioGRID	empirical	16717091
EZH2	CITED4	BioGRID	empirical	20211142
EZH2	DNMT1	HPRD, IntAct	empirical	16357870
EZH2	DNMT3A	HPRD, IntAct	empirical	16357870
EZH2	DNMT3B	HPRD, IntAct	empirical	16357870
EZH2	AKT1	HPRD	empirical	16224021
EZH2	MTF2	IntAct, BioGRID	empirical	20064376 20123894
EZH2	NINL	HPRD, MINT, IntAct	empirical	16169070
EZH2	SETX	IntAct, BioGRID	empirical	20064376
EZH2	TRIM35	IntAct, BioGRID	empirical	20064376
EZH2	SUZ12	HPRD, IntAct, BioGRID	empirical	16224021 20064375 20064376 20123894
EZH2	MORC3	IntAct, BioGRID	empirical	20064376
EZH2	KLHDC2	HPRD, MINT, IntAct	empirical	16169070
EZH2	POLA2	HPRD, MINT, IntAct	empirical	16169070
EZH2	GTF3C1	HPRD, MINT, IntAct	empirical	16169070
EZH2	HTT	BioGRID	empirical	19933700
EZH2	HDAC1	HPRD, IntAct	empirical	10581039 12900441
EZH2	JARID2	IntAct, BioGRID	empirical	20064375 20064376 20123894
EZH2	ARNTL	BioGRID	empirical	16717091
EZH2	ATP1A1	HPRD, MINT, IntAct	empirical	16169070
EZH2	PHF1	HPRD, IntAct	empirical	11571280
EZH2	PIN4	HPRD, IntAct	empirical	16169070
EZH2	PML	IntAct	empirical	17560333
EZH2	ATRX	HPRD	empirical	9499421
EZH2	WSB2	HPRD, MINT, IntAct	empirical	16169070
EZH2	PSMB6	HPRD, MINT, IntAct	empirical	16169070
EZH2	RARA	IntAct	empirical	17560333
EZH2	RBBP4	IntAct, BioGRID	empirical	20064376 20123894
EZH2	RBBP7	IntAct, BioGRID	empirical	20064376
EZH2	RBL2	BioGRID	empirical	15077161
EZH2	RPN2	HPRD, MINT, IntAct	empirical	16169070
EZH2	SMS	HPRD, MINT, IntAct	empirical	16169070
EZH2	VAV1	HPRD	empirical	8649418 10780782
EZH2	WDR61	HPRD, MINT, IntAct	empirical	16169070
EZH2	EED	HPRD, MINT, IntAct, BioGRID	empirical	9584197 10581039 9742080 20064375 20064376 12900441
EZH2	CLOCK	BioGRID	empirical	16717091

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 14

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 320

PRC2 directly methylates GATA4 and represses its transcriptional activity.
He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT
Genes Dev. 2012
PubMed ID: 22215809
EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR.
Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, Ge K, Thiele CJ
Cancer Res. 2012
PubMed ID: 22068036
Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells.
Mochizuki-Kashio M, Mishima Y, Miyagi S, Negishi M, Saraya A, Konuma T, Shinga J, Koseki H, Iwama A
Blood. 2011
PubMed ID: 22042701
Evidence for alteration of EZH2, BMI1, and KDM6A and epigenetic reprogramming in human papillomavirus type 16 E6/E7-expressing keratinocytes.
Hyland PL, McDade SS, McCloskey R, Dickson GJ, Arthur K, McCance DJ, Patel D
J Virol. 2011
PubMed ID: 21865393
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans.
Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, Shang JL, Gao CF, Zhang FR, Wang F, Sun SH
Hepatology. 2011
PubMed ID: 21769904
Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage.
Wu Z, Lee ST, Qiao Y, Li Z, Lee PL, Lee YJ, Jiang X, Tan J, Aau M, Lim CZ, Yu Q
Cell Death Differ. 2011
PubMed ID: 21546904
The tumor suppressor gene rap1GAP is silenced by miR-101-mediated EZH2 overexpression in invasive squamous cell carcinoma.
Banerjee R, Mani RS, Russo N, Scanlon CS, Tsodikov A, Jing X, Cao Q, Palanisamy N, Metwally T, Inglehart RC, Tomlins S, Bradford C, Carey T, Wolf G, Kalyana-Sundaram S, Chinnaiyan AM, Varambally S, D'Silva NJ
Oncogene. 2011
PubMed ID: 21532618
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
Jankowska AM, Makishima H, Tiu RV, Szpurka H, Huang Y, Traina F, Visconte V, Sugimoto Y, Prince C, O'Keefe C, Hsi ED, List A, Sekeres MA, Rao A, McDevitt MA, Maciejewski JP
Blood. 2011
PubMed ID: 21828135
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states.
Wigle TJ, Knutson SK, Jin L, Kuntz KW, Pollock RM, Richon VM, Copeland RA, Scott MP
FEBS Lett. 2011
PubMed ID: 21856302
Malignant rhabdoid tumors express stem cell factors, which relate to the expression of EZH2 and Id proteins.
Venneti S, Le P, Martinez D, Xie SX, Sullivan LM, Rorke-Adams LB, Pawel B, Judkins AR
Am J Surg Pathol. 2011
PubMed ID: 21921784
MEK-ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes.
Fujii S, Tokita K, Wada N, Ito K, Yamauchi C, Ito Y, Ochiai A
Oncogene. 2011
PubMed ID: 21499305
Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.
Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N
J Biol Chem. 2011
PubMed ID: 21757686
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.
Lee ST, Li Z, Wu Z, Aau M, Guan P, Karuturi RK, Liou YC, Yu Q
Mol Cell. 2011
PubMed ID: 21884980
Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.
Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S
Development. 2011
PubMed ID: 21795281
Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.
Friedman J, Cho WK, Chu CK, Keedy KS, Archin NM, Margolis DM, Karn J
J Virol. 2011
PubMed ID: 21715480
Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and invasion in cervical cancer.
Fang J, Zhang M, Li Q
Am J Med Sci. 2011
PubMed ID: 21629038
Overexpression of EZH2 and loss of expression of PTEN is associated with invasion, metastasis, and poor progression of gallbladder adenocarcinoma.
Liu DC, Yang ZL
Pathol Res Pract. 2011
PubMed ID: 21719208
The binding activity of Mel-18 at the Il17a promoter is regulated by the integrated signals of the TCR and polarizing cytokines.
Hod-Dvorai R, Jacob E, Boyko Y, Avni O
Eur J Immunol. 2011
PubMed ID: 21674483
Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis.
Trenkmann M, Brock M, Gay RE, Kolling C, Speich R, Michel BA, Gay S, Huber LC
Ann Rheum Dis. 2011
PubMed ID: 21515604
Comparison of gene expression profiles reveals aberrant expression of FOXO1, Aurora A/B and EZH2 in lesional psoriatic skins.
Liu Y, Luo W, Chen S
Mol Biol Rep. 2011
PubMed ID: 21116854
The expression pattern of polycomb group protein Ezh2 during mouse embryogenesis.
Ningxia Z, Shuyan L, Zhongjing S, Ling C, Tianzhong M, Lifeng W, Yan Y, Leili L, Xiancai C, Haibin C
Anat Rec (Hoboken). 2011
PubMed ID: 21630475
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker.
Takawa M, Masuda K, Kunizaki M, Daigo Y, Takagi K, Iwai Y, Cho HS, Toyokawa G, Yamane Y, Maejima K, Field HI, Kobayashi T, Akasu T, Sugiyama M, Tsuchiya E, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R
Cancer Sci. 2011
PubMed ID: 21539681
Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms.
Abdel-Wahab O, Pardanani A, Patel J, Wadleigh M, Lasho T, Heguy A, Beran M, Gilliland DG, Levine RL, Tefferi A
Leukemia. 2011
PubMed ID: 21455215
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor.
Testoni B, Schinzari V, Guerrieri F, Gerbal-Chaloin S, Blandino G, Levrero M
Oncogene. 2011
PubMed ID: 21399658
Inhibition of SIRT1 increases EZH2 protein level and enhances the repression of EZH2 on target gene expression.
Lu L, Li L, Lü X, Wu XS, Liu DP, Liang CC
Chin Med Sci J. 2011
PubMed ID: 21703114
EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.
Cheng AS, Lau SS, Chen Y, Kondo Y, Li MS, Feng H, Ching AK, Cheung KF, Wong HK, Tong JH, Jin H, Choy KW, Yu J, To KF, Wong N, Huang TH, Sung JJ
Cancer Res. 2011
PubMed ID: 21512140
EZH2 and ALDH-1 mark breast epithelium at risk for breast cancer development.
Kunju LP, Cookingham C, Toy KA, Chen W, Sabel MS, Kleer CG
Mod Pathol. 2011
PubMed ID: 21399615
High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not.
Findeis-Hosey JJ, Huang J, Li F, Yang Q, McMahon LA, Xu H
Hum Pathol. 2011
PubMed ID: 21292308
Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring.
Xu F, Li X, Wu L, Zhang Q, Yang R, Yang Y, Zhang Z, He Q, Chang C
Ann Hematol. 2011
PubMed ID: 21125401
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.
Orzan F, Pellegatta S, Poliani PL, Pisati F, Caldera V, Menghi F, Kapetis D, Marras C, Schiffer D, Finocchiaro G
Neuropathol Appl Neurobiol. 2011
PubMed ID: 20946108
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.
Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS
Science. 2011
PubMed ID: 21596989
Aberrations of EZH2 in cancer.
Chase A, Cross NC
Clin Cancer Res. 2011
PubMed ID: 21367748
Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance.
Grossmann V, Kohlmann A, Eder C, Haferlach C, Kern W, Cross NC, Haferlach T, Schnittger S
Leukemia. 2011
PubMed ID: 21339759
Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.
Sasaki D, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, Choi YL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
Haematologica. 2011
PubMed ID: 21228036
Tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex.
Xu B, Zeng DQ, Wu Y, Zheng R, Gu L, Lin X, Hua X, Jin GH
J Biol Chem. 2011
PubMed ID: 21378168
Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells.
Juan AH, Derfoul A, Feng X, Ryall JG, Dell'Orso S, Pasut A, Zare H, Simone JM, Rudnicki MA, Sartorelli V
Genes Dev. 2011
PubMed ID: 21498568
EZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression.
Fan T, Jiang S, Chung N, Alikhan A, Ni C, Lee CC, Hornyak TJ
Mol Cancer Res. 2011
PubMed ID: 21383005
Enhancer of zeste homolog 2 overexpression has a role in the development of anaplastic thyroid carcinomas.
Borbone E, Troncone G, Ferraro A, Jasencakova Z, Stojic L, Esposito F, Hornig N, Fusco A, Orlando V
J Clin Endocrinol Metab. 2011
PubMed ID: 21289264
EZH2 Y641 mutations in follicular lymphoma.
Bödör C, O'Riain C, Wrench D, Matthews J, Iyengar S, Tayyib H, Calaminici M, Clear A, Iqbal S, Quentmeier H, Drexler HG, Montoto S, Lister AT, Gribben JG, Matolcsy A, Fitzgibbon J
Leukemia. 2011
PubMed ID: 21233829
EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling.
Yu YL, Chou RH, Chen LT, Shyu WC, Hsieh SC, Wu CS, Zeng HJ, Yeh SP, Yang DM, Hung SC, Hung MC
J Biol Chem. 2011
PubMed ID: 21216957
Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.
Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG
Cancer Res. 2011
PubMed ID: 21406404
DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.
Zheng S, Houseman EA, Morrison Z, Wrensch MR, Patoka JS, Ramos C, Haas-Kogan DA, McBride S, Marsit CJ, Christensen BC, Nelson HH, Stokoe D, Wiemels JL, Chang SM, Prados MD, Tihan T, Vandenberg SR, Kelsey KT, Berger MS, Wiencke JK
Neuro Oncol. 2011
PubMed ID: 21339190
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.
Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E
Genes Dev. 2011
PubMed ID: 21317239
Genetics of the myeloproliferative neoplasms.
Abdel-Wahab O
Curr Opin Hematol. 2011
PubMed ID: 21307773
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
Fukuda T, Tokunaga A, Sakamoto R, Yoshida N
Mol Cell Neurosci. 2011
PubMed ID: 21220025
EZH2 regulates expression of p57 and contributes to progression of ovarian cancer in vitro and in vivo.
Guo J, Cai J, Yu L, Tang H, Chen C, Wang Z
Cancer Sci. 2011
PubMed ID: 21205084
Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.
Boulay G, Rosnoblet C, Guérardel C, Angrand PO, Leprince D
Biochem J. 2011
PubMed ID: 21143197
Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.
Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF
FASEB J. 2011
PubMed ID: 21135039
Absence of mutations of the histone methyltransferase gene EZH2 in splenic b-cell marginal zone lymphoma.
Salido M, Martinez-Avilés L, Ademà V, Ferrer A, Espinet B, Garcia M, Salar A, Besses C, Florensa L, Serrano S, Bellosillo B, Solé F
Leuk Res. 2011
PubMed ID: 21087793
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, Marquez VE, Marra MA, Gascoyne RD, Humphries RK, Arrowsmith CH, Morin GB, Aparicio SA
Blood. 2011
PubMed ID: 21190999
Aberrant expression of EZH2 is associated with a poor outcome and P53 alteration in squamous cell carcinoma of the esophagus.
Yamada A, Fujii S, Daiko H, Nishimura M, Chiba T, Ochiai A
Int J Oncol. 2011
PubMed ID: 21165554
Ezh2 expression in astrocytes induces their dedifferentiation toward neural stem cells.
Sher F, Boddeke E, Copray S
Cell Reprogram. 2011
PubMed ID: 20979531
Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence.
Cho J, Shen H, Yu H, Li H, Cheng T, Lee SB, Lee BC
Blood. 2011
PubMed ID: 21030557
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling.
Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC
Cancer Cell. 2011
PubMed ID: 21215703
EZH2 depletion blocks the proliferation of colon cancer cells.
Fussbroich B, Wagener N, Macher-Goeppinger S, Benner A, Fälth M, Sültmann H, Holzer A, Hoppe-Seyler K, Hoppe-Seyler F
PLoS One. 2011
PubMed ID: 21765901
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
The value of TOP2A, EZH2 and paxillin expression as markers of aggressive breast cancer: relationship with other prognostic factors.
Panousis D, Patsouris E, Lagoudianakis E, Pappas A, Kyriakidou V, Voulgaris Z, Xepapadakis G, Manouras A, Athanassiadou AM, Athanassiadou P
Eur J Gynaecol Oncol. 2011
PubMed ID: 21614903
Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications.
Ciarapica R, Miele L, Giordano A, Locatelli F, Rota R
BMC Med. 2011
PubMed ID: 21609503
DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs.
So AY, Jung JW, Lee S, Kim HS, Kang KS
PLoS One. 2011
PubMed ID: 21572997
Enhancer of zeste homologue 2 expression in breast carcinoma smears in relationship with p53, Ki-67 and other prognostic parameters.
Athanassiadou AM, Tsipis A, Patsouris E, Gonidi M, Nicolopoulou-Stamati P, Chelidonis G, Athanassiadou P
Acta Cytol. 2011
PubMed ID: 21325804
Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.
Smits M, Mir SE, Nilsson RJ, van der Stoop PM, Niers JM, Marquez VE, Cloos J, Breakefield XO, Krichevsky AM, Noske DP, Tannous BA, Würdinger T
PLoS One. 2011
PubMed ID: 21297974
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2.
Lu J, He ML, Wang L, Chen Y, Liu X, Dong Q, Chen YC, Peng Y, Yao KT, Kung HF, Li XP
Cancer Res. 2011
PubMed ID: 21199804
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC
Nat Cell Biol. 2011
PubMed ID: 21131960
Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer.
Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q
Carcinogenesis. 2011
PubMed ID: 20952513
Decreased expression of EZH2 is associated with upregulation of ER and favorable outcome to tamoxifen in advanced breast cancer.
Reijm EA, Jansen MP, Ruigrok-Ritstier K, van Staveren IL, Look MP, van Gelder ME, Sieuwerts AM, Sleijfer S, Foekens JA, Berns EM
Breast Cancer Res Treat. 2011
PubMed ID: 20306127
Genome-wide identification of polycomb-associated RNAs by RIP-seq.
Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT
Mol Cell. 2010
PubMed ID: 21172659
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM, Elemento O
Blood. 2010
PubMed ID: 20736451
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
Sneeringer CJ, Scott MP, Kuntz KW, Knutson SK, Pollock RM, Richon VM, Copeland RA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21078963
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis.
Smits M, Nilsson J, Mir SE, van der Stoop PM, Hulleman E, Niers JM, de Witt Hamer PC, Marquez VE, Cloos J, Krichevsky AM, Noske DP, Tannous BA, Würdinger T
Oncotarget. 2010
PubMed ID: 21321380
Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells.
Lei L, Lu L, Xiang L, Xue-song W, De-pei L, Chih-chuan L
Chin Med Sci J. 2010
PubMed ID: 21232178
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.
Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, Reinberg D
Genes Dev. 2010
PubMed ID: 21123648
Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells.
Li H, Cai Q, Godwin AK, Zhang R
Mol Cancer Res. 2010
PubMed ID: 21115743
Dynamic patterns of histone lysine methylation in the developing retina.
Rao RC, Tchedre KT, Malik MT, Coleman N, Fang Y, Marquez VE, Chen DF
Invest Ophthalmol Vis Sci. 2010
PubMed ID: 20671280
ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2.
Kalashnikova EV, Revenko AS, Gemo AT, Andrews NP, Tepper CG, Zou JX, Cardiff RD, Borowsky AD, Chen HW
Cancer Res. 2010
PubMed ID: 20864510
Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5.
Hawkins PG, Morris KV
Transcription. 2010
PubMed ID: 21151833
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H
Nat Cell Biol. 2010
PubMed ID: 20935635
Somatic mutations altering Tyr641 of EZH2 are rare in primary central nervous system lymphoma.
Pellissery S, Richter J, Haake A, Montesinos-Rongen M, Deckert M, Siebert R
Leuk Lymphoma. 2010
PubMed ID: 20858097
RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo.
Chen Y, Xie D, Yin Li W, Man Cheung C, Yao H, Chan CY, Chan CY, Xu FP, Liu YH, Sung JJ, Kung HF
Cancer Lett. 2010
PubMed ID: 20684863
The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets.
Van Dessel N, Beke L, Görnemann J, Minnebo N, Beullens M, Tanuma N, Shima H, Van Eynde A, Bollen M
Nucleic Acids Res. 2010
PubMed ID: 20671031
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.
Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, Nakayama T
J Exp Med. 2010
PubMed ID: 20956546
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.
Wilson BG, Wang X, Shen X, McKenna ES, Lemieux ME, Cho YJ, Koellhoffer EC, Pomeroy SL, Orkin SH, Roberts CW
Cancer Cell. 2010
PubMed ID: 20951942
Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo.
Hu S, Yu L, Li Z, Shen Y, Wang J, Cai J, Xiao L, Wang Z
Cancer Biol Ther. 2010
PubMed ID: 20686362
Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies.
Makishima H, Jankowska AM, Tiu RV, Szpurka H, Sugimoto Y, Hu Z, Saunthararajah Y, Guinta K, Keddache MA, Putnam P, Sekeres MA, Moliterno AR, List AF, McDevitt MA, Maciejewski JP
Leukemia. 2010
PubMed ID: 20724984
Regulation of the Polycomb protein RING1B ubiquitination by USP7.
de Bie P, Zaaroor-Regev D, Ciechanover A
Biochem Biophys Res Commun. 2010
PubMed ID: 20800574
Mutational analysis of EZH2 codon 641 in non-Hodgkin lymphomas and leukemias.
Park SW, Chung NG, Eom HS, Yoo NJ, Lee SH
Leuk Res. 2010
PubMed ID: 20863566
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Pereira JD, Sansom SN, Smith J, Dobenecker MW, Tarakhovsky A, Livesey FJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20798045
Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis.
Ciavatta DJ, Yang J, Preston GA, Badhwar AK, Xiao H, Hewins P, Nester CM, Pendergraft WF, Magnuson TR, Jennette JC, Falk RJ
J Clin Invest. 2010
PubMed ID: 20714105
Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma.
Toll AD, Dasgupta A, Potoczek M, Yeo CJ, Kleer CG, Brody JR, Witkiewicz AK
Hum Pathol. 2010
PubMed ID: 20573371
Regulation of tumor angiogenesis by EZH2.
Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung MC, Lopez-Berestein G, Sood AK
Cancer Cell. 2010
PubMed ID: 20708159
Long noncoding RNA as modular scaffold of histone modification complexes.
Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, Shi Y, Segal E, Chang HY
Science. 2010
PubMed ID: 20616235
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.
Majewski IJ, Ritchie ME, Phipson B, Corbin J, Pakusch M, Ebert A, Busslinger M, Koseki H, Hu Y, Smyth GK, Alexander WS, Hilton DJ, Blewitt ME
Blood. 2010
PubMed ID: 20445021
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes.
Nikoloski G, Langemeijer SM, Kuiper RP, Knops R, Massop M, Tönnissen ER, van der Heijden A, Scheele TN, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH
Nat Genet. 2010
PubMed ID: 20601954
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders.
Ernst T, Chase AJ, Score J, Hidalgo-Curtis CE, Bryant C, Jones AV, Waghorn K, Zoi K, Ross FM, Reiter A, Hochhaus A, Drexler HG, Duncombe A, Cervantes F, Oscier D, Boultwood J, Grand FH, Cross NC
Nat Genet. 2010
PubMed ID: 20601953
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
High expression of EZH2 is associated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy.
He LR, Liu MZ, Li BK, Jia WH, Zhang Y, Liao YJ, Chen YC, Zhang LJ, Guan XY, Zeng YX, Kung HF, Xie D
Int J Cancer. 2010
PubMed ID: 19904743
Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.
Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Konishi J, Oizumi S, Kaga K, Matsuno Y, Nishimura M, Dosaka-Akita H
Cancer. 2010
PubMed ID: 20564407
ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.
Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG
Cell Stem Cell. 2010
PubMed ID: 20569692
In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer.
Doherty LF, Bromer JG, Zhou Y, Aldad TS, Taylor HS
Horm Cancer. 2010
PubMed ID: 21761357
The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.
Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A
J Hepatol. 2010
PubMed ID: 20395008
EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis.
Wang CG, Ye YJ, Yuan J, Liu FF, Zhang H, Wang S
World J Gastroenterol. 2010
PubMed ID: 20480530
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
Cancer Cell. 2010
PubMed ID: 20478527
Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines.
Karanikolas BD, Figueiredo ML, Wu L
Prostate. 2010
PubMed ID: 20087897
Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression.
Wu ZL, Zheng SS, Li ZM, Qiao YY, Aau MY, Yu Q
Cell Death Differ. 2010
PubMed ID: 19893569
Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.
Wang L, Jin Q, Lee JE, Su IH, Ge K
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20368440
Expression of polycomb protein EZH2 in multi-stage tissues of gastric carcinogenesis.
Cai GH, Wang K, Miao Q, Peng YS, Chen XY
J Dig Dis. 2010
PubMed ID: 20402834
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and metastasis in gastric cancer.
Choi JH, Song YS, Yoon JS, Song KW, Lee YY
APMIS. 2010
PubMed ID: 20132185
The knock-down of overexpressed EZH2 and BMI-1 does not prevent osteosarcoma growth.
Sasaki H, Setoguchi T, Matsunoshita Y, Gao H, Hirotsu M, Komiya S
Oncol Rep. 2010
PubMed ID: 20127006
The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival.
Balasubramanian S, Adhikary G, Eckert RL
Carcinogenesis. 2010
PubMed ID: 20015867
Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells.
Dimri M, Bommi PV, Sahasrabuddhe AA, Khandekar JD, Dimri GP
Carcinogenesis. 2010
PubMed ID: 19969553
Jarid2 and PRC2, partners in regulating gene expression.
Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D
Genes Dev. 2010
PubMed ID: 20123894
Huntingtin facilitates polycomb repressive complex 2.
Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, Macdonald ME
Hum Mol Genet. 2010
PubMed ID: 19933700
Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation.
Walker E, Chang WY, Hunkapiller J, Cagney G, Garcha K, Torchia J, Krogan NJ, Reiter JF, Stanford WL
Cell Stem Cell. 2010
PubMed ID: 20144788
[EZH2 expression in human prostate cancer and its clinicopathologic significance]
Li J, Fan QH, Fan XS, Zhou W, Qiu Y, Qiu L
Zhonghua Nan Ke Xue. 2010
PubMed ID: 20369694
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, Paul JE, Boyle M, Woolcock BW, Kuchenbauer F, Yap D, Humphries RK, Griffith OL, Shah S, Zhu H, Kimbara M, Shashkin P, Charlot JF, Tcherpakov M, Corbett R, Tam A, Varhol R, Smailus D, Moksa M, Zhao Y, Delaney A, Qian H, Birol I, Schein J, Moore R, Holt R, Horsman DE, Connors JM, Jones S, Aparicio S, Hirst M, Gascoyne RD, Marra MA
Nat Genet. 2010
PubMed ID: 20081860
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis.
Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA
Gastroenterology. 2010
PubMed ID: 19843474
Enhancer of Zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98.
Alajez NM, Shi W, Hui AB, Bruce J, Lenarduzzi M, Ito E, Yue S, O'Sullivan B, Liu FF
Cell Death Dis. 2010
PubMed ID: 21368858
Epigenetic silencing of peroxisome proliferator-activated receptor γ is a biomarker for colorectal cancer progression and adverse patients' outcome.
Pancione M, Sabatino L, Fucci A, Carafa V, Nebbioso A, Forte N, Febbraro A, Parente D, Ambrosino C, Normanno N, Altucci L, Colantuoni V
PLoS One. 2010
PubMed ID: 21151932
Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.
Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM, Levitt P
Neural Dev. 2010
PubMed ID: 21122108
Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma.
Wagener N, Macher-Goeppinger S, Pritsch M, Hüsing J, Hoppe-Seyler K, Schirmacher P, Pfitzenmaier J, Haferkamp A, Hoppe-Seyler F, Hohenfellner M
BMC Cancer. 2010
PubMed ID: 20920340
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.
Acharyya S, Sharma SM, Cheng AS, Ladner KJ, He W, Kline W, Wang H, Ostrowski MC, Huang TH, Guttridge DC
PLoS One. 2010
PubMed ID: 20814569
ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer.
Kunderfranco P, Mello-Grand M, Cangemi R, Pellini S, Mensah A, Albertini V, Malek A, Chiorino G, Catapano CV, Carbone GM
PLoS One. 2010
PubMed ID: 20479932
MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta.
Cao P, Deng Z, Wan M, Huang W, Cramer SD, Xu J, Lei M, Sui G
Mol Cancer. 2010
PubMed ID: 20478051
Genetic polymorphisms in the polycomb group gene EZH2 and the risk of lung cancer.
Yoon KA, Gil HJ, Han J, Park J, Lee JS
J Thorac Oncol. 2010
PubMed ID: 19901851
Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.
Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH
Cell. 2009
PubMed ID: 20064376
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J
Cell. 2009
PubMed ID: 20064375
EZH2 is essential for glioblastoma cancer stem cell maintenance.
Suvà ML, Riggi N, Janiszewska M, Radovanovic I, Provero P, Stehle JC, Baumer K, Le Bitoux MA, Marino D, Cironi L, Marquez VE, Clément V, Stamenkovic I
Cancer Res. 2009
PubMed ID: 19934320
Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex.
Schaefer A, Sampath SC, Intrator A, Min A, Gertler TS, Surmeier DJ, Tarakhovsky A, Greengard P
Neuron. 2009
PubMed ID: 20005824
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Sun F, Chan E, Wu Z, Yang X, Marquez VE, Yu Q
Mol Cancer Ther. 2009
PubMed ID: 19934278
Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis.
Fluge Ø, Gravdal K, Carlsen E, Vonen B, Kjellevold K, Refsum S, Lilleng R, Eide TJ, Halvorsen TB, Tveit KM, Otte AP, Akslen LA, Dahl O, Norwegian Gastrointestinal Cancer Group
Br J Cancer. 2009
PubMed ID: 19773751
Mir-214-dependent regulation of the polycomb protein Ezh2 in skeletal muscle and embryonic stem cells.
Juan AH, Kumar RM, Marx JG, Young RA, Sartorelli V
Mol Cell. 2009
PubMed ID: 19818710
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.
Hirabayashi Y, Suzki N, Tsuboi M, Endo TA, Toyoda T, Shinga J, Koseki H, Vidal M, Gotoh Y
Neuron. 2009
PubMed ID: 19755104
Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line.
Karanikolas BD, Figueiredo ML, Wu L
Mol Cancer Res. 2009
PubMed ID: 19723877
Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia.
Li X, Gonzalez ME, Toy K, Filzen T, Merajver SD, Kleer CG
Am J Pathol. 2009
PubMed ID: 19661437
Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin.
Yamaguchi J, Sasaki M, Harada K, Zen Y, Sato Y, Ikeda H, Itatsu K, Yokoyama Y, Ando H, Ohta T, Kubota A, Shimizu K, Nimura Y, Nagino M, Nakanuma Y
Lab Invest. 2009
PubMed ID: 19564843
Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.
Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O
Hum Pathol. 2009
PubMed ID: 19386347
Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation.
Rush M, Appanah R, Lee S, Lam LL, Goyal P, Lorincz MC
Epigenetics. 2009
PubMed ID: 19717977
Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes.
Shaw T, Martin P
EMBO Rep. 2009
PubMed ID: 19575012
Regulation of CD11b transcription by decreasing PRC2 and increased acH4 level during ATRA-induced HL-60 differentiation.
Tang H, Chen F, Tan Q, Tan S, Liu L, Zhang F
Acta Biochim Biophys Sin (Shanghai). 2009
PubMed ID: 19578722
Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube.
Miró X, Zhou X, Boretius S, Michaelis T, Kubisch C, Alvarez-Bolado G, Gruss P
Dis Model Mech. 2009
PubMed ID: 19535498
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells.
Fiskus W, Buckley K, Rao R, Mandawat A, Yang Y, Joshi R, Wang Y, Balusu R, Chen J, Koul S, Joshi A, Upadhyay S, Atadja P, Bhalla KN
Cancer Biol Ther. 2009
PubMed ID: 19279403
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation.
Richter GH, Plehm S, Fasan A, Rössler S, Unland R, Bennani-Baiti IM, Hotfilder M, Löwel D, von Luettichau I, Mossbrugger I, Quintanilla-Martinez L, Kovar H, Staege MS, Müller-Tidow C, Burdach S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19289832
Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells.
Ezhkova E, Pasolli HA, Parker JS, Stokes N, Su IH, Hannon G, Tarakhovsky A, Fuchs E
Cell. 2009
PubMed ID: 19303854
The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.
Friedman JM, Liang G, Liu CC, Wolff EM, Tsai YC, Ye W, Zhou X, Jones PA
Cancer Res. 2009
PubMed ID: 19258506
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19202064
Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1.
Gonzalez ME, Li X, Toy K, DuPrie M, Ventura AC, Banerjee M, Ljungman M, Merajver SD, Kleer CG
Oncogene. 2009
PubMed ID: 19079346
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS
Genome Biol. 2009
PubMed ID: 19799774
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.
Puppe J, Drost R, Liu X, Joosse SA, Evers B, Cornelissen-Steijger P, Nederlof P, Yu Q, Jonkers J, van Lohuizen M, Pietersen AM
Breast Cancer Res. 2009
PubMed ID: 19709408
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells.
Yang X, Karuturi RK, Sun F, Aau M, Yu K, Shao R, Miller LD, Tan PB, Yu Q
PLoS One. 2009
PubMed ID: 19340297
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B, Laxman B, Cao X, Jing X, Ramnarayanan K, Brenner JC, Yu J, Kim JH, Han B, Tan P, Kumar-Sinha C, Lonigro RJ, Palanisamy N, Maher CA, Chinnaiyan AM
Science. 2008
PubMed ID: 19008416
Repression of E-cadherin by the polycomb group protein EZH2 in cancer.
Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA, Mehra R, Laxman B, Cao X, Yu J, Kleer CG, Varambally S, Chinnaiyan AM
Oncogene. 2008
PubMed ID: 18806826
Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein.
Holland D, Hoppe-Seyler K, Schuller B, Lohrey C, Maroldt J, Dürst M, Hoppe-Seyler F
Cancer Res. 2008
PubMed ID: 19047178
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D
Mol Cell. 2008
PubMed ID: 19026781
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
Shen X, Liu Y, Hsu YJ, Fujiwara Y, Kim J, Mao X, Yuan GC, Orkin SH
Mol Cell. 2008
PubMed ID: 19026780
MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
Sander S, Bullinger L, Klapproth K, Fiedler K, Kestler HA, Barth TF, Möller P, Stilgenbauer S, Pollack JR, Wirth T
Blood. 2008
PubMed ID: 18713946
Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2.
Ougolkov AV, Bilim VN, Billadeau DD
Clin Cancer Res. 2008
PubMed ID: 18980972
A model for transmission of the H3K27me3 epigenetic mark.
Hansen KH, Bracken AP, Pasini D, Dietrich N, Gehani SS, Monrad A, Rappsilber J, Lerdrup M, Helin K
Nat Cell Biol. 2008
PubMed ID: 18931660
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos.
Terranova R, Yokobayashi S, Stadler MB, Otte AP, van Lohuizen M, Orkin SH, Peters AH
Dev Cell. 2008
PubMed ID: 18848501
Differentiation of neural stem cells into oligodendrocytes: involvement of the polycomb group protein Ezh2.
Sher F, Rössler R, Brouwer N, Balasubramaniyan V, Boddeke E, Copray S
Stem Cells. 2008
PubMed ID: 18687996
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.
Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT
Science. 2008
PubMed ID: 18974356
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells.
Wagener N, Holland D, Bulkescher J, Crnković-Mertens I, Hoppe-Seyler K, Zentgraf H, Pritsch M, Buse S, Pfitzenmaier J, Haferkamp A, Hohenfellner M, Hoppe-Seyler F
Int J Cancer. 2008
PubMed ID: 18623083
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma.
Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y
Lab Invest. 2008
PubMed ID: 18591938
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.
Herranz N, Pasini D, Díaz VM, Francí C, Gutierrez A, Dave N, Escrivà M, Hernandez-Muñoz I, Di Croce L, Helin K, García de Herreros A, Peiró S
Mol Cell Biol. 2008
PubMed ID: 18519590
Polycomb group protein-associated chromatin is reproduced in post-mitotic G1 phase and is required for S phase progression.
Aoto T, Saitoh N, Sakamoto Y, Watanabe S, Nakao M
J Biol Chem. 2008
PubMed ID: 18453536
A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations.
Tiwari VK, Cope L, McGarvey KM, Ohm JE, Baylin SB
Genome Res. 2008
PubMed ID: 18502945
Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation.
Fujii S, Ito K, Ito Y, Ochiai A
J Biol Chem. 2008
PubMed ID: 18430739
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C, Yamochi T, Urano T, Furukawa K, Kwabi-Addo B, Gold DL, Sekido Y, Huang TH, Issa JP
Nat Genet. 2008
PubMed ID: 18488029
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA, Helin K
Genes Dev. 2008
PubMed ID: 18483221
A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A
Nucleic Acids Res. 2008
PubMed ID: 18385154
Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.
Majewski IJ, Blewitt ME, de Graaf CA, McManus EJ, Bahlo M, Hilton AA, Hyland CD, Smyth GK, Corbin JE, Metcalf D, Alexander WS, Hilton DJ
PLoS Biol. 2008
PubMed ID: 18416604
Expression changes of CAV1 and EZH2, located on 7q31 approximately q36, are rarely related to genomic alterations in primary prostate carcinoma.
Bachmann N, Haeusler J, Luedeke M, Kuefer R, Perner S, Assum G, Paiss T, Hoegel J, Vogel W, Maier C
Cancer Genet Cytogenet. 2008
PubMed ID: 18406871
MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis.
Wong CF, Tellam RL
J Biol Chem. 2008
PubMed ID: 18281287
Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells.
Fujii S, Ochiai A
Cancer Sci. 2008
PubMed ID: 18377425
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, Kolb C, Otte AP, Koseki H, Orkin SH, van Lohuizen M, Peters AH
Nat Genet. 2008
PubMed ID: 18311137
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D
Mol Cell Biol. 2008
PubMed ID: 18285464
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Role of hPHF1 in H3K27 methylation and Hox gene silencing.
Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y
Mol Cell Biol. 2008
PubMed ID: 18086877
Expression of the polycomb group protein EZH2 and its relation to outcome in patients with urothelial carcinoma of the bladder.
Hinz S, Kempkensteffen C, Christoph F, Hoffmann M, Krause H, Schrader M, Schostak M, Miller K, Weikert S
J Cancer Res Clin Oncol. 2008
PubMed ID: 17694325
The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells.
Bryant RJ, Winder SJ, Cross SS, Hamdy FC, Cunliffe VT
Prostate. 2008
PubMed ID: 18095286
Independent prognostic value of the basal-like phenotype of breast cancer and associations with EGFR and candidate stem cell marker BMI-1.
Arnes JB, Collett K, Akslen LA
Histopathology. 2008
PubMed ID: 18269588
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer.
Pietersen AM, Horlings HM, Hauptmann M, Langerød A, Ajouaou A, Cornelissen-Steijger P, Wessels LF, Jonkers J, van de Vijver MJ, van Lohuizen M
Breast Cancer Res. 2008
PubMed ID: 19099573
The polycomb repressive complex 2 is a potential target of SUMO modifications.
Riising EM, Boggio R, Chiocca S, Helin K, Pasini D
PLoS ONE. 2008
PubMed ID: 18628979
EZH2 regulates the transcription of estrogen-responsive genes through association with REA, an estrogen receptor corepressor.
Hwang C, Giri VN, Wilkinson JC, Wright CW, Wilkinson AS, Cooney KA, Duckett CS
Breast Cancer Res Treat. 2008
PubMed ID: 17453341
Identification of enhancer of zeste homolog 2 expression in peripheral circulating tumor cells in metastatic prostate cancer patients: a preliminary study.
Cho KS, Oh HY, Lee EJ, Hong SJ
Yonsei Med J. 2007
PubMed ID: 18159594
New nomenclature for chromatin-modifying enzymes.
Allis CD, Berger SL, Cote J, Dent S, Jenuwien T, Kouzarides T, Pillus L, Reinberg D, Shi Y, Shiekhattar R, Shilatifard A, Workman J, Zhang Y
Cell. 2007
PubMed ID: 18022353
Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer.
Yu J, Cao Q, Mehra R, Laxman B, Yu J, Tomlins SA, Creighton CJ, Dhanasekaran SM, Shen R, Chen G, Morris DS, Marquez VE, Shah RB, Ghosh D, Varambally S, Chinnaiyan AM
Cancer Cell. 2007
PubMed ID: 17996646
A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma.
Holling TM, Bergevoet MW, Wilson L, Van Eggermond MC, Schooten E, Steenbergen RD, Snijders PJ, Jager MJ, Van den Elsen PJ
J Immunol. 2007
PubMed ID: 17911618
Structural basis of EZH2 recognition by EED.
Han Z, Xing X, Hu M, Zhang Y, Liu P, Chai J
Structure. 2007
PubMed ID: 17937919
Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
Hoffmann MJ, Engers R, Florl AR, Otte AP, Muller M, Schulz WA
Cancer Biol Ther. 2007
PubMed ID: 18637271
The transcriptional repression by NIPP1 is mediated by Polycomb group proteins.
Roy N, Van Eynde A, Beke L, Nuytten M, Bollen M
Biochim Biophys Acta. 2007
PubMed ID: 17804093
Proteomic analysis of EZH2 downstream target proteins in hepatocellular carcinoma.
Chen Y, Lin MC, Wang H, Chan CY, Jiang L, Ngai SM, Yu J, He ML, Shaw PC, Yew DT, Sung JJ, Kung HF
Proteomics. 2007
PubMed ID: 17676662
Expression of polycomb group protein EZH2 in nevi and melanoma.
McHugh JB, Fullen DR, Ma L, Kleer CG, Su LD
J Cutan Pathol. 2007
PubMed ID: 17640228
Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features.
van Leenders GJ, Dukers D, Hessels D, van den Kieboom SW, Hulsbergen CA, Witjes JA, Otte AP, Meijer CJ, Raaphorst FM
Eur Urol. 2007
PubMed ID: 17134822
The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2.
Beke L, Nuytten M, Van Eynde A, Beullens M, Bollen M
Oncogene. 2007
PubMed ID: 17237810
Lentivirus-mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down-regulation of stathmin.
Chen Y, Lin MC, Yao H, Wang H, Zhang AQ, Yu J, Hui CK, Lau GK, He ML, Sung J, Kung HF
Hepatology. 2007
PubMed ID: 17596871
Integration of estrogen and Wnt signaling circuits by the polycomb group protein EZH2 in breast cancer cells.
Shi B, Liang J, Yang X, Wang Y, Zhao Y, Wu H, Sun L, Zhang Y, Chen Y, Li R, Zhang Y, Hong M, Shang Y
Mol Cell Biol. 2007
PubMed ID: 17502350
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.
Villa R, Pasini D, Gutierrez A, Morey L, Occhionorelli M, Viré E, Nomdedeu JF, Jenuwein T, Pelicci PG, Minucci S, Fuks F, Helin K, Di Croce L
Cancer Cell. 2007
PubMed ID: 17560333
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.
McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB
Cancer Res. 2007
PubMed ID: 17545586
Epigenetic control of hematopoietic stem cell aging the case of Ezh2.
De Haan G, Gerrits A
Ann N Y Acad Sci. 2007
PubMed ID: 17332078
Developmental regulation of Eed complex composition governs a switch in global histone modification in brain.
Kim SY, Levenson JM, Korsmeyer S, Sweatt JD, Schumacher A
J Biol Chem. 2007
PubMed ID: 17259173
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K
Genes Dev. 2007
PubMed ID: 17344414
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, Eden E, Yakhini Z, Ben-Shushan E, Reubinoff BE, Bergman Y, Simon I, Cedar H
Nat Genet. 2007
PubMed ID: 17200670
EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder.
Hinz S, Kempkensteffen C, Weikert S, Schostak M, Schrader M, Miller K, Christoph F
Tumour Biol. 2007
PubMed ID: 17541304
pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene.
Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y
Genes Dev. 2007
PubMed ID: 17210787
Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.
Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K
Mol Cancer Ther. 2006
PubMed ID: 17172412
Juxtaposed Polycomb complexes co-regulate vertebral identity.
Kim SY, Paylor SW, Magnuson T, Schumacher A
Development. 2006
PubMed ID: 17107999
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast.
Ding L, Kleer CG
Cancer Res. 2006
PubMed ID: 17018586
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells.
Kim DH, Villeneuve LM, Morris KV, Rossi JJ
Nat Struct Mol Biol. 2006
PubMed ID: 16936726
The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer.
Zeidler M, Kleer CG
J Mol Histol. 2006
PubMed ID: 16855786
Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.
Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV
Cell Cycle. 2006
PubMed ID: 16963837
The polycomb group protein EZH2 is required for mammalian circadian clock function.
Etchegaray JP, Yang X, DeBruyne JP, Peters AH, Weaver DR, Jenuwein T, Reppert SM
J Biol Chem. 2006
PubMed ID: 16717091
The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer.
Saramäki OR, Tammela TL, Martikainen PM, Vessella RL, Visakorpi T
Genes Chromosomes Cancer. 2006
PubMed ID: 16575874
New insights into BS69 functions.
Velasco G, Grkovic S, Ansieau S
J Biol Chem. 2006
PubMed ID: 16565076
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.
Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K
Genes Dev. 2006
PubMed ID: 16618801
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
Substrate preferences of the EZH2 histone methyltransferase complex.
Martin C, Cao R, Zhang Y
J Biol Chem. 2006
PubMed ID: 16431907
The Polycomb group protein EZH2 directly controls DNA methylation.
Viré E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, Bollen M, Esteller M, Di Croce L, de Launoit Y, Fuks F
Nature. 2006
PubMed ID: 16357870
Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer.
Collett K, Eide GE, Arnes J, Stefansson IM, Eide J, Braaten A, Aas T, Otte AP, Akslen LA
Clin Cancer Res. 2006
PubMed ID: 16489070
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T
Nat Cell Biol. 2006
PubMed ID: 16415857
Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder.
Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS, Gudas LJ
Clin Cancer Res. 2005
PubMed ID: 16361539
Association of BMI1 with polycomb bodies is dynamic and requires PRC2/EZH2 and the maintenance DNA methyltransferase DNMT1.
Hernández-Muñoz I, Taghavi P, Kuijl C, Neefjes J, van Lohuizen M
Mol Cell Biol. 2005
PubMed ID: 16314526
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells.
Zeidler M, Varambally S, Cao Q, Chinnaiyan AM, Ferguson DO, Merajver SD, Kleer CG
Neoplasia. 2005
PubMed ID: 16331887
Mutation screen and association study of EZH2 as a susceptibility gene for aggressive prostate cancer.
Bachmann N, Hoegel J, Haeusler J, Kuefer R, Herkommer K, Paiss T, Vogel W, Maier C
Prostate. 2005
PubMed ID: 16015586
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC
Science. 2005
PubMed ID: 16224021
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
Epping MT, Wang L, Edel MJ, Carlée L, Hernandez M, Bernards R
Cell. 2005
PubMed ID: 16179254
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells.
Koyanagi M, Baguet A, Martens J, Margueron R, Jenuwein T, Bix M
J Biol Chem. 2005
PubMed ID: 16009709
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.
Bertolino E, Reddy K, Medina KL, Parganas E, Ihle J, Singh H
Nat Immunol. 2005
PubMed ID: 16025120
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer.
Chen H, Tu SW, Hsieh JT
J Biol Chem. 2005
PubMed ID: 15817459
Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma.
Sudo T, Utsunomiya T, Mimori K, Nagahara H, Ogawa K, Inoue H, Wakiyama S, Fujita H, Shirouzu K, Mori M
Br J Cancer. 2005
PubMed ID: 15856046
Polycomb group protein ezh2 controls actin polymerization and cell signaling.
Su IH, Dobenecker MW, Dickinson E, Oser M, Basavaraj A, Marqueron R, Viale A, Reinberg D, Wülfing C, Tarakhovsky A
Cell. 2005
PubMed ID: 15882624
X chromosome reactivation and regulation in cloned embryos.
Nolen LD, Gao S, Han Z, Mann MR, Gie Chung Y, Otte AP, Bartolomei MS, Latham KE
Dev Biol. 2005
PubMed ID: 15733677
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, Ouyang X, Brockdorff N, Abate-Shen C, Farnham P, Reinberg D
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15684044
A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, Wagener C, Sardet C, Moroni MC, Helin K
J Biol Chem. 2005
PubMed ID: 15536069
Increased expression of EZH2, a polycomb group protein, in bladder carcinoma.
Arisan S, Buyuktuncer ED, Palavan-Unsal N, Caşkurlu T, Cakir OO, Ergenekon E
Urol Int. 2005
PubMed ID: 16215315
Tagging genes with cassette-exchange sites.
Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R
Nucleic Acids Res. 2005
PubMed ID: 15741177
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.
Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B
J Cell Biol. 2004
PubMed ID: 15596546
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes.
Umlauf D, Goto Y, Cao R, Cerqueira F, Wagschal A, Zhang Y, Feil R
Nat Genet. 2004
PubMed ID: 15516932
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.
Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V
Genes Dev. 2004
PubMed ID: 15520282
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K
EMBO J. 2004
PubMed ID: 15385962
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Age-associated alteration of gene expression patterns in mouse oocytes.
Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS
Hum Mol Genet. 2004
PubMed ID: 15317747
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Activated p53 suppresses the histone methyltransferase EZH2 gene.
Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N, Rotter V
Oncogene. 2004
PubMed ID: 15208672
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
Cao R, Zhang Y
Mol Cell. 2004
PubMed ID: 15225548
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
Kirmizis A, Bartley SM, Kuzmichev A, Margueron R, Reinberg D, Green R, Farnham PJ
Genes Dev. 2004
PubMed ID: 15231737
Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A.
Tonini T, Bagella L, D'Andrilli G, Claudio PP, Giordano A
Oncogene. 2004
PubMed ID: 15077161
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3.
Kuzmichev A, Jenuwein T, Tempst P, Reinberg D
Mol Cell. 2004
PubMed ID: 15099518
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Reactivation of the paternal X chromosome in early mouse embryos.
Mak W, Nesterova TB, de Napoles M, Appanah R, Yamanaka S, Otte AP, Brockdorff N
Science. 2004
PubMed ID: 14752160
Epigenetic dynamics of imprinted X inactivation during early mouse development.
Okamoto I, Otte AP, Allis CD, Reinberg D, Heard E
Science. 2004
PubMed ID: 14671313
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1.
Violot S, Hong SS, Rakotobe D, Petit C, Gay B, Moreau K, Billaud G, Priet S, Sire J, Schwartz O, Mouscadet JF, Boulanger P
J Virol. 2003
PubMed ID: 14610174
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene.
Raaphorst FM, Meijer CJ, Fieret E, Blokzijl T, Mommers E, Buerger H, Packeisen J, Sewalt RA, Otte AP, van Diest PJ
Neoplasia. 2003
PubMed ID: 14965441
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K
EMBO J. 2003
PubMed ID: 14532106
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.
Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA, Ghosh D, Sewalt RG, Otte AP, Hayes DF, Sabel MS, Livant D, Weiss SJ, Rubin MA, Chinnaiyan AM
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14500907
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development.
Erhardt S, Su IH, Schneider R, Barton S, Bannister AJ, Perez-Burgos L, Jenuwein T, Kouzarides T, Tarakhovsky A, Surani MA
Development. 2003
PubMed ID: 12900441
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
The DNA sequence of human chromosome 7.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
Nature. 2003
PubMed ID: 12853948
Human chromosome 7: DNA sequence and biology.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC
Science. 2003
PubMed ID: 12690205
Role of histone H3 lysine 27 methylation in X inactivation.
Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y
Science. 2003
PubMed ID: 12649488
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.
Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N
Dev Cell. 2003
PubMed ID: 12689588
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.
Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, van Lohuizen M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12589020
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.
Su IH, Basavaraj A, Krutchinsky AN, Hobert O, Ullrich A, Chait BT, Tarakhovsky A
Nat Immunol. 2003
PubMed ID: 12496962
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D
Genes Dev. 2002
PubMed ID: 12435631
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y
Science. 2002
PubMed ID: 12351676
The polycomb group protein EZH2 is involved in progression of prostate cancer.
Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, Sanda MG, Ghosh D, Pienta KJ, Sewalt RG, Otte AP, Rubin MA, Chinnaiyan AM
Nature. 2002
PubMed ID: 12374981
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins.
Sewalt RG, Lachner M, Vargas M, Hamer KM, den Blaauwen JL, Hendrix T, Melcher M, Schweizer D, Jenuwein T, Otte AP
Mol Cell Biol. 2002
PubMed ID: 12101246
Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells.
Mak W, Baxter J, Silva J, Newall AE, Otte AP, Brockdorff N
Curr Biol. 2002
PubMed ID: 12123576
Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.
O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS
J Biol Chem. 2001
PubMed ID: 11571280
The polycomb-group gene Ezh2 is required for early mouse development.
O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T
Mol Cell Biol. 2001
PubMed ID: 11390661
Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation.
Raaphorst FM, Otte AP, van Kemenade FJ, Blokzijl T, Fieret E, Hamer KM, Satijn DP, Meijer CJ
J Immunol. 2001
PubMed ID: 11342607
Xenopus Enhancer of Zeste (XEZ); an anteriorly restricted polycomb gene with a role in neural patterning.
Barnett MW, Seville RA, Nijjar S, Old RW, Jones EA
Mech Dev. 2001
PubMed ID: 11287189
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos.
Satijn DP, Hamer KM, den Blaauwen J, Otte AP
Mol Cell Biol. 2001
PubMed ID: 11158321
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders.
Cardoso C, Mignon C, Hetet G, Grandchamps B, Fontes M, Colleaux L
Eur J Hum Genet. 2000
PubMed ID: 10780782
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation.
van der Vlag J, Otte AP
Nat Genet. 1999
PubMed ID: 10581039
The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6.
Laible G, Haynes AR, Lebersorger A, O'Carroll D, Mattei MG, Denny P, Brown SD, Jenuwein T
Mamm Genome. 1999
PubMed ID: 10051331
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Point mutations in the WD40 domain of Eed block its interaction with Ezh2.
Denisenko O, Shnyreva M, Suzuki H, Bomsztyk K
Mol Cell Biol. 1998
PubMed ID: 9742080
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.
Sewalt RG, van der Vlag J, Gunster MJ, Hamer KM, den Blaauwen JL, Satijn DP, Hendrix T, van Driel R, Otte AP
Mol Cell Biol. 1998
PubMed ID: 9584199
Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes.
van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E
Mol Cell Biol. 1998
PubMed ID: 9584197
Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.
Cardoso C, Timsit S, Villard L, Khrestchatisky M, Fontès M, Colleaux L
Hum Mol Genet. 1998
PubMed ID: 9499421
Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.
Ogawa M, Hiraoka Y, Taniguchi K, Aiso S
Biochim Biophys Acta. 1998
PubMed ID: 9473645
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.
Laible G, Wolf A, Dorn R, Reuter G, Nislow C, Lebersorger A, Popkin D, Pillus L, Jenuwein T
EMBO J. 1997
PubMed ID: 9214638
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon.
Shirasawa S, Yunker AM, Roth KA, Brown GA, Horning S, Korsmeyer SJ
Nat Med. 1997
PubMed ID: 9176491
Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2.
Chen H, Rossier C, Antonarakis SE
Genomics. 1996
PubMed ID: 8954776
Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.
Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL
Genomics. 1996
PubMed ID: 8921387
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.
Hobert O, Jallal B, Ullrich A
Mol Cell Biol. 1996
PubMed ID: 8649418
Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene.
Hobert O, Sures I, Ciossek T, Fuchs M, Ullrich A
Mech Dev. 1996
PubMed ID: 8861097

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2146	14056	312299
EnsEMBL Gene(s)	ENSG00000106462	ENSMUSG00000029687	ENSRNOG00000006048
Unigene	Hs.444082	Mm.246688	Rn.9027
Homologene	EZH2	Ezh2	Ezh2
OMIM	601573	N/A	N/A
GeneCards	EZH2	N/A	N/A
Beta Cell Genomics	DT.100790710 DT.448498	DT.101389800 DT.101389801 DT.102539627 DT.535194 DT.97372109	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	2146	14056	312299

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site