AKT1

Summary Top Help

Gene Description:

v-akt murine thymoma viral oncogene homolog 1; thymoma viral proto-oncogene 1

Synonyms:

AKT1, Akt1, RAC, PKBalpha, PRKBA, Rac, Akt, RAC-ALPHA, PKB, PKB-ALPHA, AKT, PKB/Akt

Orthologs:

Human AKT1 (protein-coding), Mouse Akt1 (protein-coding), Rat Akt1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 2

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm8	Rat	chr6:110581307..147636619	37.06	308

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm29	Rat	chr6:127683728..146651354	18.97	229

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr14:105235686..105262088 (26.40 kb) View in Genome Browser

(Mouse) NCBIM37 - chr12:113892032..113913095 (216 kb) View in Genome Browser

(Rat) RGSC3.4 - chr6:137640482..137657552 (177 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for AKT1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for AKT1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 39

Biocarta: 31

Reactome: 34

NCI-Nature Pathway Interaction Database: 58

Gene Ontology: 88

Protein import into nucleus, translocation	GO:0000060
Nucleotide binding	GO:0000166
Positive regulation of protein phosphorylation	GO:0001934
Protein kinase activity	GO:0004672
Protein serine/threonine kinase activity	GO:0004674
Protein binding	GO:0005515
ATP binding	GO:0005524
Phosphatidylinositol-3,4,5-trisphosphate binding	GO:0005547
Membrane fraction	GO:0005624
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Cytosol	GO:0005829
Plasma membrane	GO:0005886
Carbohydrate metabolic process	GO:0005975
Regulation of glycogen biosynthetic process	GO:0005979
Regulation of translation	GO:0006417
Protein modification process	GO:0006464
Protein phosphorylation	GO:0006468
Negative regulation of protein kinase activity	GO:0006469
Nitric oxide biosynthetic process	GO:0006809
Transport	GO:0006810
Apoptotic process	GO:0006915
Anti-apoptosis	GO:0006916
Activation-induced cell death of T cells	GO:0006924
Signal transduction	GO:0007165
Epidermal growth factor receptor signaling pathway	GO:0007173
G-protein coupled receptor signaling pathway	GO:0007186
Multicellular organismal development	GO:0007275
Nervous system development	GO:0007399
Blood coagulation	GO:0007596
Cell proliferation	GO:0008283
Insulin receptor signaling pathway	GO:0008286
Fibroblast growth factor receptor signaling pathway	GO:0008543
Induction of apoptosis by intracellular signals	GO:0008629
Activation of pro-apoptotic gene products	GO:0008633
Carbohydrate transport	GO:0008643
Response to heat	GO:0009408
Gene expression	GO:0010467
Negative regulation of plasma membrane long-chain fatty acid transport	GO:0010748
Positive regulation of glucose metabolic process	GO:0010907
Regulation of neuron projection development	GO:0010975
Microtubule cytoskeleton	GO:0015630
RNA metabolic process	GO:0016070
MRNA metabolic process	GO:0016071
Kinase activity	GO:0016301
Phosphorylation	GO:0016310
Peptidyl-serine phosphorylation	GO:0018105
Enzyme binding	GO:0019899
Cell differentiation	GO:0030154
Platelet activation	GO:0030168
Nitric-oxide synthase regulator activity	GO:0030235
Positive regulation of cell growth	GO:0030307
Regulation of cell migration	GO:0030334
Endocrine pancreas development	GO:0031018
T cell costimulation	GO:0031295
Positive regulation of cyclin-dependent protein kinase activity involved in G1/S	GO:0031659
Negative regulation of fatty acid beta-oxidation	GO:0031999
Positive regulation of cellular protein metabolic process	GO:0032270
Cellular response to insulin stimulus	GO:0032869
Positive regulation of peptidyl-serine phosphorylation	GO:0033138
Response to fluid shear stress	GO:0034405
Intracellular signal transduction	GO:0035556
Identical protein binding	GO:0042802
Negative regulation of apoptotic process	GO:0043066
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0043154
Phosphatidylinositol-3,4-bisphosphate binding	GO:0043325
Positive regulation of blood vessel endothelial cell migration	GO:0043536
Small molecule metabolic process	GO:0044281
Positive regulation of nitric oxide biosynthetic process	GO:0045429
Positive regulation of fat cell differentiation	GO:0045600
Positive regulation of glycogen biosynthetic process	GO:0045725
Positive regulation of anti-apoptosis	GO:0045768
Nitric oxide metabolic process	GO:0046209
Positive regulation of glucose import	GO:0046326
Protein autophosphorylation	GO:0046777
Positive regulation of lipid biosynthetic process	GO:0046889
Insulin-like growth factor receptor signaling pathway	GO:0048009
Nerve growth factor receptor signaling pathway	GO:0048011
Phosphatidylinositol-mediated signaling	GO:0048015
Regulation of nitric-oxide synthase activity	GO:0050999
Positive regulation of nitric-oxide synthase activity	GO:0051000
Positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091
Mammary gland epithelial cell differentiation	GO:0060644
Response to UV-A	GO:0070141
Positive regulation of establishment of protein localization in plasma membrane	GO:0090004
Negative regulation of release of cytochrome c from mitochondria	GO:0090201
Regulation of G1/S transition checkpoint	GO:2001047

Publications from PubMed Top Help

Type 1 Diabetes Publications: 41

Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
Baragli A, Ghè C, Arnoletti E, Granata R, Ghigo E, Muccioli G
Biochim Biophys Acta. 2011
PubMed ID: 21435395
Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation.
Hie M, Iitsuka N, Otsuka T, Tsukamoto I
Int J Mol Med. 2011
PubMed ID: 21567076
Suppression of the PI3K-Akt pathway is involved in the decreased adhesion and migration of bone marrow-derived mesenchymal stem cells from non-obese diabetic mice.
Li L, Xia Y, Wang Z, Cao X, Da Z, Guo G, Qian J, Liu X, Fan Y, Sun L, Sang A, Gu Z
Cell Biol Int. 2011
PubMed ID: 21449895
Participation of Akt, Menin, and p21 in Pregnancy-Induced {beta}-Cell Proliferation.
Hughes E, Huang C
Endocrinology. 2011
PubMed ID: 21239436
α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.
Huang G, Ge G, Wang D, Gopalakrishnan B, Butz DH, Colman RJ, Nagy A, Greenspan DS
J Clin Invest. 2011
PubMed ID: 21293061
Promiscuous affairs of PKB/AKT isoforms in metabolism.
Schultze SM, Jensen J, Hemmings BA, Tschopp O, Niessen M
Arch Physiol Biochem. 2011
PubMed ID: 21214427
UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression.
Bromati CR, Lellis-Santos C, Yamanaka TS, Nogueira TC, Leonelli M, Caperuto LC, Gorjão R, Leite AR, Anhê GF, Bordin S
Am J Physiol Regul Integr Comp Physiol. 2011
PubMed ID: 21068199
The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
Wang Y, Ozawa A, Zaman S, Prasad NB, Chandrasekharappa SC, Agarwal SK, Marx SJ
Cancer Res. 2010
PubMed ID: 21127195
ADIPONECTIN INDUCED ERK AND AKT PHOSPHORYLATION PROTECTS AGAINST PANCREATIC BETA CELL APOPTOSIS AND INCREASES INSULIN GENE EXPRESSION AND SECRETION.
Wijesekara N, Krishnamurthy M, Bhattacharjee A, Suhail A, Sweeney G, Wheeler MB
J Biol Chem. 2010
PubMed ID: 20709750
Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells.
Vogel R, Garten A, Klammt J, Barnikol-Oettler A, Kiess W
Arch Physiol Biochem. 2010
PubMed ID: 20536329
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED, Komuro I
J Clin Invest. 2010
PubMed ID: 20407209
Atrial natriuretic peptide promotes pancreatic islet beta-cell growth and Akt/Foxo1a/cyclin D2 signaling.
You H, Laychock SG
Endocrinology. 2009
PubMed ID: 19837876
Differential effects of PKB/Akt isoforms on glucose homeostasis and islet mass.
Buzzi F, Xu L, Zuellig RA, Boller SB, Spinas GA, Hynx D, Chang Z, Yang Z, Hemmings BA, Tschopp O, Niessen M
Mol Cell Biol. 2009
PubMed ID: 19933838
AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1.
Ishigaki S, Fonseca SG, Oslowski CM, Jurczyk A, Shearstone JR, Zhu LJ, Permutt MA, Greiner DL, Bortell R, Urano F
Cell Death Differ. 2009
PubMed ID: 19911006
Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic {beta}-Cell Growth.
Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ
Mol Endocrinol. 2009
PubMed ID: 19897600
Forkhead Box O1/Pancreatic and Duodenal Homeobox 1 Intracellular Translocation Is Regulated by c-Jun N-Terminal Kinase and Involved in Prostaglandin E2-Induced Pancreatic {beta}-Cell Dysfunction.
Meng Z, Lv J, Luo Y, Lin Y, Zhu Y, Nie J, Yang T, Sun Y, Han X
Endocrinology. 2009
PubMed ID: 19837872
Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and Akt kinases.
Humphrey RK, Yu SM, Flores LE, Jhala US
J Biol Chem. 2009
PubMed ID: 19833727
Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice.
Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M
Diabetologia. 2009
PubMed ID: 19644667
Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.
Westmoreland JJ, Wang Q, Bouzaffour M, Baker SJ, Sosa-Pineda B
Dev Biol. 2009
PubMed ID: 19635472
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of Apoptosis Signal regulating Kinase 1 constitutes a core component of the {beta}-cell pro-survival effects of glucose-dependent insulinotropic polypeptide.
Widenmaier SB, Ao Z, Kim SJ, Warnock G, McIntosh CH
J Biol Chem. 2009
PubMed ID: 19748889
Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.
Chen WS, Peng XD, Wang Y, Xu PZ, Chen ML, Luo Y, Jeon SM, Coleman K, Haschek WM, Bass J, Philipson LH, Hay N
Mol Cell Biol. 2009
PubMed ID: 19289493
Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide.
Widenmaier SB, Sampaio AV, Underhill TM, McIntosh CH
J Biol Chem. 2009
PubMed ID: 19233842
Regulation of pancreas plasticity and malignant transformation by Akt signaling.
Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E
Gastroenterology. 2009
PubMed ID: 19121634
The TRbeta1 is essential in mediating T3 action on Akt pathway in human pancreatic insulinoma cells.
Verga Falzacappa C, Patriarca V, Bucci B, Mangialardo C, Michienzi S, Moriggi G, Stigliano A, Brunetti E, Toscano V, Misiti S
J Cell Biochem. 2009
PubMed ID: 19160403
Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.
Uzan B, Figeac F, Portha B, Movassat J
PLoS ONE. 2009
PubMed ID: 19266047
O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.
Kang ES, Han D, Park J, Kwak TK, Oh MA, Lee SA, Choi S, Park ZY, Kim Y, Lee JW
Exp Cell Res. 2008
PubMed ID: 18570920
Decreased Fetal Size is Associated with Beta Cell Hyperfunction in Early Life and Failure with Age.
Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF
Diabetes. 2008
PubMed ID: 18591393
Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.
Cai Y, Wang Q, Ling Z, Pipeleers D, McDermott P, Pende M, Heimberg H, Van de Casteele M
Biochem Pharmacol. 2008
PubMed ID: 18377870
Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt.
Yano T, Liu Z, Donovan J, Thomas MK, Habener JF
Diabetes. 2007
PubMed ID: 17878289
Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells.
Pugazhenthi S, Akhov L, Selvaraj G, Wang M, Alam J
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17535857
Pancreatic glucokinase is activated by insulin-like growth factor-I.
Yoshida K, Murao K, Imachi H, Cao WM, Yu X, Li J, Ahmed RA, Kitanaka N, Wong NC, Unterman TG, Magnuson MA, Ishida T
Endocrinology. 2007
PubMed ID: 17317782
Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade.
Kim SJ, Nian C, McIntosh CH
J Biol Chem. 2007
PubMed ID: 17244606
Modulation of the production of reactive oxygen species (ROS) by cAMP-elevating agents in granulocytes from diabetic patients: an Akt/PKB-dependent phenomenon.
Nogueira-Machado JA, Lima e Silva FC, Cunha EP, Calsolari MR, Costa DC, Perilo CS, Horta BC, Ferreira IC, Chaves MM
Diabetes Metab. 2006
PubMed ID: 16977260
Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H
Mol Cell Biol. 2006
PubMed ID: 16537919
Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.
Jetton TL, Lausier J, LaRock K, Trotman WE, Larmie B, Habibovic A, Peshavaria M, Leahy JL
Diabetes. 2005
PubMed ID: 16046294
Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
Li L, El-Kholy W, Rhodes CJ, Brubaker PL
Diabetologia. 2005
PubMed ID: 15902400
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regu
Kim SJ, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh CH
J Biol Chem. 2005
PubMed ID: 15817464
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.
Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, Polonsky KS, Permutt MA
J Clin Invest. 2004
PubMed ID: 15467831
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
Dickson LM, Rhodes CJ
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15271644
Glucose promotes pancreatic islet beta-cell survival through a PI 3-kinase/Akt-signaling pathway.
Srinivasan S, Bernal-Mizrachi E, Ohsugi M, Permutt MA
Am J Physiol Endocrinol Metab. 2002
PubMed ID: 12217896
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha.
Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, Furth EE, Polonsky KS, Naji A, Birnbaum MJ
Nat Med. 2001
PubMed ID: 11590437

Publications: 2519

Activation of AKT is associated with metastasis of nasopharyngeal carcinoma.
Liu Y, Chen LH, Yuan YW, Li QS, Sun AM, Guan J
Tumour Biol. 2012
PubMed ID: 22116667
AKT1 polymorphisms and survival of early stage non-small cell lung cancer.
Kim MJ, Kang HG, Lee SY, Jeon HS, Lee WK, Park JY, Lee EB, Lee JH, Cha SI, Kim DS, Kim CH, Kam S, Jung TH, Park JY
J Surg Oncol. 2012
PubMed ID: 21842521
Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function.
Balu DT, Carlson GC, Talbot K, Kazi H, Hill-Smith TE, Easton RM, Birnbaum MJ, Lucki I
Hippocampus. 2012
PubMed ID: 21049487
Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization.
Kim CK, Lee SB, Nguyen TL, Lee KH, Um SH, Kim J, Ahn JY
Exp Cell Res. 2012
PubMed ID: 21930127
Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade.
Moon JB, Kim JH, Kim K, Youn BU, Ko A, Lee SY, Kim N
J Immunol. 2012
PubMed ID: 22131333
Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development.
Mukherjee A, Rotwein P
Mol Cell Biol. 2012
PubMed ID: 22064480
Modulation of AKT activity is associated with reversible dormancy in ascites-derived epithelial ovarian cancer spheroids.
Correa RJ, Peart T, Valdes YR, DiMattia GE, Shepherd TG
Carcinogenesis. 2012
PubMed ID: 22045027
Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.
Wan M, Easton RM, Gleason CE, Monks BR, Ueki K, Kahn CR, Birnbaum MJ
Mol Cell Biol. 2012
PubMed ID: 22037765
PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients.
Alyasiri NS, Mehdi SJ, Alam MS, Ali A, Mandal AK, Gupta S, Singh I, Rizvi MM
J Cancer Res Clin Oncol. 2012
PubMed ID: 22033727
Fascin, a novel marker of human hepatic stellate cells, may regulate their proliferation, migration, and collagen gene expression through the FAK-PI3K-Akt pathway.
Uyama N, Iimuro Y, Kawada N, Reynaert H, Suzumura K, Hirano T, Kuroda N, Fujimoto J
Lab Invest. 2012
PubMed ID: 22005766
Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.
Chatterjee S, Browning EA, Hong N, DeBolt K, Sorokina EM, Liu W, Birnbaum MJ, Fisher AB
Am J Physiol Heart Circ Physiol. 2012
PubMed ID: 22003059
IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells.
New DD, Block K, Bhandhari B, Gorin Y, Abboud HE
Am J Physiol Cell Physiol. 2012
PubMed ID: 21940672
SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.
Fenouille N, Puissant A, Tichet M, Zimniak G, Abbe P, Mallavialle A, Rocchi S, Ortonne JP, Deckert M, Ballotti R, Tartare-Deckert S
Oncogene. 2011
PubMed ID: 21685937
Silencing p110β prevents rapid depletion of nuclear pAkt.
Ye ZW, Ghalali A, Högberg J, Stenius U
Biochem Biophys Res Commun. 2011
PubMed ID: 22074824
Targeting AKT protein kinase in gastric cancer.
Almhanna K, Strosberg J, Malafa M
Anticancer Res. 2011
PubMed ID: 22199303
Modulation of PGE2-induced EP4 expression on snail signaling and the impact on epithelial-mesenchymal transition: significance of EP4 antagonism.
Kim HN, Narayanan NK, Lasano S, Narayanan B
Anticancer Res. 2011
PubMed ID: 22199300
Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
Schulten HJ, Al-Maghrabi J, Al-Ghamdi K, Salama S, Al-Muhayawi S, Chaudhary A, Hamour O, Abuzenadah A, Gari M, Al-Qahtani M
Anticancer Res. 2011
PubMed ID: 22199277
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
Wakatsuki S, Saitoh F, Araki T
Nat Cell Biol. 2011
PubMed ID: 22057101
Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas.
Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, Shin N, Ishida K, Morikawa T, Motoi F, Unno M, Kanno A, Satoh K, Shimosegawa T, Orikasa H, Watanabe T, Nishimura K, Harada Y, Furukawa T
Am J Surg Pathol. 2011
PubMed ID: 21945955
Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation.
Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y
Hum Mol Genet. 2011
PubMed ID: 21890492
Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood.
de Roock S, Hoeks SB, Meurs L, Steur A, Hoekstra MO, Prakken BJ, Boes M, de Kleer IM
J Allergy Clin Immunol. 2011
PubMed ID: 21868077
The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.
Bach M, Larance M, James DE, Ramm G
Biochem J. 2011
PubMed ID: 21819378
Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells.
Grabinski N, Bartkowiak K, Grupp K, Brandt B, Pantel K, Jücker M
Cell Signal. 2011
PubMed ID: 21777670
Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (A
Manna P, Jain SK
J Biol Chem. 2011
PubMed ID: 21953448
Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.
Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22031698
Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer.
Yoo YA, Kang MH, Lee HJ, Kim BH, Park JK, Kim HK, Kim JS, Oh SC
Cancer Res. 2011
PubMed ID: 21975935
EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction.
Jin X, Yin J, Kim SH, Sohn YW, Beck S, Lim YC, Nam DH, Choi YJ, Kim H
Cancer Res. 2011
PubMed ID: 21975932
Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.
Case N, Thomas J, Sen B, Styner M, Xie Z, Galior K, Rubin J
J Biol Chem. 2011
PubMed ID: 21956113
Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2.
Warfel NA, Niederst M, Newton AC
J Biol Chem. 2011
PubMed ID: 21908613
Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.
Magri L, Cambiaghi M, Cominelli M, Alfaro-Cervello C, Cursi M, Pala M, Bulfone A, Garcìa-Verdugo JM, Leocani L, Minicucci F, Poliani PL, Galli R
Cell Stem Cell. 2011
PubMed ID: 22056141
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
Rapley J, Oshiro N, Ortiz-Vega S, Avruch J
J Biol Chem. 2011
PubMed ID: 21914810
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX
J Clin Invest. 2011
PubMed ID: 21965330
Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis.
Ondracek CR, McLachlan A
J Virol. 2011
PubMed ID: 21880746
PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling.
Huang W, András IE, Rha GB, Hennig B, Toborek M
FASEB J. 2011
PubMed ID: 21840940
Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells.
Pan JJ, Chang QS, Wang X, Son YO, Liu J, Zhang Z, Bi YY, Shi X
Int J Oncol. 2011
PubMed ID: 21837363
Mechanotransduction activates α₅β₁ integrin and PI3K/Akt signaling pathways in mandibular osteoblasts.
Watabe H, Furuhama T, Tani-Ishii N, Mikuni-Takagaki Y
Exp Cell Res. 2011
PubMed ID: 21824471
Normal endometrial stromal cells regulate survival and apoptosis signaling through PI3K/AKt/Survivin pathway in endometrial adenocarcinoma cells in vitro.
Shi M, Zhang H, Li M, Xue J, Fu Y, Yan L, Zhao X
Gynecol Oncol. 2011
PubMed ID: 21794903
Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition.
Sun H, Yu T, Li J
Cancer Lett. 2011
PubMed ID: 21775054
Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.
Su CH, Wang CY, Lan KH, Li CP, Chao Y, Lin HC, Lee SD, Lee WP
Cell Signal. 2011
PubMed ID: 21767636
FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.
Tzivion G, Dobson M, Ramakrishnan G
Biochim Biophys Acta. 2011
PubMed ID: 21708191
The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase.
Guntur AR, Rosen CJ
J Endocrinol. 2011
PubMed ID: 21673026
Low expression of PP2A regulatory subunit B55α is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients.
Ruvolo PP, Qui YH, Coombes KR, Zhang N, Ruvolo VR, Borthakur G, Konopleva M, Andreeff M, Kornblau SM
Leukemia. 2011
PubMed ID: 21660042
The PKB/FOXO switch in aging and cancer.
Kloet DE, Burgering BM
Biochim Biophys Acta. 2011
PubMed ID: 21539865
Interplay between FOXO, TOR, and Akt.
Hay N
Biochim Biophys Acta. 2011
PubMed ID: 21440577
Akt, FoxO and regulation of apoptosis.
Zhang X, Tang N, Hadden TJ, Rishi AK
Biochim Biophys Acta. 2011
PubMed ID: 21440011
Regulation of FoxO transcription factors by acetylation and protein-protein interactions.
Daitoku H, Sakamaki J, Fukamizu A
Biochim Biophys Acta. 2011
PubMed ID: 21396404
CNK1 and other scaffolds for Akt/FoxO signaling.
Fritz RD, Radziwill G
Biochim Biophys Acta. 2011
PubMed ID: 21320536
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
Huang H, Tindall DJ
Biochim Biophys Acta. 2011
PubMed ID: 21238503
IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
Guo JP, Coppola D, Cheng JQ
J Biol Chem. 2011
PubMed ID: 21908616
Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas.
Hatton O, Phillips LK, Vaysberg M, Hurwich J, Krams SM, Martinez OM
J Biol Chem. 2011
PubMed ID: 21908615
Chemokine CXCL12 uses CXCR4 and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK)1/2, and mammalian target of rapamycin complex 1 (mTORC1) proteins to control chemotaxis and survival simultaneously in mature dendriti
Delgado-Martín C, Escribano C, Pablos JL, Riol-Blanco L, Rodríguez-Fernández JL
J Biol Chem. 2011
PubMed ID: 21878648
Protein kinase B is involved in Nogo-66 inhibiting neurite outgrowth in PC12 cells.
Wang H, Shen J, Xiong N, Zhao H, Chen Y
Neuroreport. 2011
PubMed ID: 21862940
The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling.
Terragni J, Nayak G, Banerjee S, Medrano JL, Graham JR, Brennan JF, Sepulveda S, Cooper GM
J Biol Chem. 2011
PubMed ID: 21873430
Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer.
Saji M, Narahara K, McCarty SK, Vasko VV, La Perle KM, Porter K, Jarjoura D, Lu C, Cheng SY, Ringel MD
Oncogene. 2011
PubMed ID: 21532616
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair.
Perdiguero E, Sousa-Victor P, Ruiz-Bonilla V, Jardí M, Caelles C, Serrano AL, Muñoz-Cánoves P
J Cell Biol. 2011
PubMed ID: 21987635
N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells.
Nalla AK, Estes N, Patel J, Rao JS
Exp Cell Res. 2011
PubMed ID: 21855541
Akt fine-tunes NF-κB-dependent gene expression during T cell activation.
Cheng J, Phong B, Wilson DC, Hirsch R, Kane LP
J Biol Chem. 2011
PubMed ID: 21862580
Tissue microarray analysis of ezrin, KBA.62, CD166, nestin, and p-Akt in melanoma versus banal and atypical nevi, and nonmelanocytic lesions.
Shanesmith RP, Smart C, Cassarino DS
Am J Dermatopathol. 2011
PubMed ID: 21915031
TGF-β stimulates biglycan core protein synthesis but not glycosaminoglycan chain elongation via Akt phosphorylation in vascular smooth muscle.
Osman N, Getachew R, Burch M, Lancaster G, Wang R, Wang H, Zheng W, Little PJ
Growth Factors. 2011
PubMed ID: 21913799
Epac1-mediated, high glucose-induced renal proximal tubular cells hypertrophy via the Akt/p21 pathway.
Sun L, Kondeti VK, Xie P, Raparia K, Kanwar YS
Am J Pathol. 2011
PubMed ID: 21854750
Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt.
Eden JS, Sharpe LJ, White PA, Brown AJ
J Virol. 2011
PubMed ID: 21849454
Mutational analysis of PTEN/PIK3CA/AKT pathway in oral squamous cell carcinoma.
Cohen Y, Goldenberg-Cohen N, Shalmon B, Shani T, Oren S, Amariglio N, Dratviman-Storobinsky O, Shnaiderman-Shapiro A, Yahalom R, Kaplan I, Hirshberg A
Oral Oncol. 2011
PubMed ID: 21824802
Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes.
Lin Y, Sun Z
J Cell Physiol. 2011
PubMed ID: 21792921
Understanding the Villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling.
Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA
Toxicol Sci. 2011
PubMed ID: 21785161
Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes.
Tarabees R, Hill D, Rauch C, Barrow PA, Loughna PT
Am J Physiol Cell Physiol. 2011
PubMed ID: 21775707
Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation.
Wu JB, Shih JC
Mol Pharmacol. 2011
PubMed ID: 21775495
Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages.
Shim YJ, Kang BH, Jeon HS, Park IS, Lee KU, Lee IK, Park GH, Lee KM, Schedin P, Min BH
J Leukoc Biol. 2011
PubMed ID: 21742938
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation.
Castino R, Fiorentino I, Cagnin M, Giovia A, Isidoro C
Toxicol Sci. 2011
PubMed ID: 21742779
Thrombin activation of PI3K/PDK1/Akt signaling promotes cyclin D1 upregulation and RPE cell proliferation.
Parrales A, López E, López-Colomé AM
Biochim Biophys Acta. 2011
PubMed ID: 21736902
Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration.
Lee MW, Kim DS, Lee JH, Lee BS, Lee SH, Jung HL, Sung KW, Kim HT, Yoo KH, Koo HH
Cancer Sci. 2011
PubMed ID: 21722267
β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma.
Chen L, Huang K, Han L, Shi Z, Zhang K, Pu P, Jiang C, Kang C
Int J Oncol. 2011
PubMed ID: 21720709
Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
Yan L, Wei X, Tang QZ, Feng J, Zhang Y, Liu C, Bian ZY, Zhang LF, Chen M, Bai X, Wang AB, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H
Cardiovasc Res. 2011
PubMed ID: 21632881
Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking.
Picone P, Giacomazza D, Vetri V, Carrotta R, Militello V, San Biagio PL, Di Carlo M
Aging Cell. 2011
PubMed ID: 21624038
Akt signalling in health and disease.
Hers I, Vincent EE, Tavaré JM
Cell Signal. 2011
PubMed ID: 21620960
Akt/PKB isoforms expression in the human lumbar herniated disc: correlation with clinical and MRI findings.
Pasku D, Soufla G, Katonis P, Tsarouhas A, Vakis A, Spandidos DA
Eur Spine J. 2011
PubMed ID: 21590431
Role of extracellular matrix renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin (alpha)vbeta3/focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B-serine/threonine kinase (AKT) signaling pa
Xie P, Kondeti VK, Lin S, Haruna Y, Raparia K, Kanwar YS
J Biol Chem. 2011
PubMed ID: 21795690
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells.
Wehrens EJ, Mijnheer G, Duurland CL, Klein M, Meerding J, van Loosdregt J, de Jager W, Sawitzki B, Coffer PJ, Vastert B, Prakken BJ, van Wijk F
Blood. 2011
PubMed ID: 21828127
Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.
Mounir Z, Krishnamoorthy JL, Wang S, Papadopoulou B, Campbell S, Muller WJ, Hatzoglou M, Koromilas AE
Sci Signal. 2011
PubMed ID: 21954288
mda-9/Syntenin protein positively regulates the activation of Akt protein by facilitating integrin-linked kinase adaptor function during adhesion to type I collagen.
Hwangbo C, Park J, Lee JH
J Biol Chem. 2011
PubMed ID: 21828040
Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway.
Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P
J Biol Chem. 2011
PubMed ID: 21799016
Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism.
Maruyama S, Shibata R, Ohashi K, Ohashi T, Daida H, Walsh K, Murohara T, Ouchi N
J Biol Chem. 2011
PubMed ID: 21784858
Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system.
Kim SY, Lee JH, Huh JW, Ro JY, Oh YM, Lee SD, An S, Lee YS
J Biol Chem. 2011
PubMed ID: 21778238
Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway.
Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Säämänen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M
J Biol Chem. 2011
PubMed ID: 21724852
Antioxidant c-FLIP inhibits Fas ligand-induced NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt-dependent manner.
Iyer AK, Azad N, Talbot S, Stehlik C, Lu B, Wang L, Rojanasakul Y
J Immunol. 2011
PubMed ID: 21856935
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT
Cell. 2011
PubMed ID: 21884932
Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation.
Ben-Ami I, Yao Z, Naor Z, Seger R
J Biol Chem. 2011
PubMed ID: 21757743
Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose-polymerase-mediated apoptosis under high-glucose stimulation.
Qin X, Zhang Z, Xu H, Wu Y
Acta Biochim Biophys Sin (Shanghai). 2011
PubMed ID: 21813561
A cell penetrating peptide derived from azurin inhibits angiogenesis and tumor growth by inhibiting phosphorylation of VEGFR-2, FAK and Akt.
Mehta RR, Yamada T, Taylor BN, Christov K, King ML, Majumdar D, Lekmine F, Tiruppathi C, Shilkaitis A, Bratescu L, Green A, Beattie CW, Das Gupta TK
Angiogenesis. 2011
PubMed ID: 21667138
AKT has an anti-apoptotic role in ABCA12-deficient keratinocytes.
Yanagi T, Akiyama M, Nishihara H, Miyamura Y, Sakai K, Tanaka S, Shimizu H
J Invest Dermatol. 2011
PubMed ID: 21633372
Melatonin prevents hepatic injury-induced decrease in Akt downstream targets phosphorylations.
Koh PO
J Pineal Res. 2011
PubMed ID: 21492218
The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.
Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, Tanoue A
J Neurosci. 2011
PubMed ID: 21880919
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
Chan JC, Hannan KM, Riddell K, Ng PY, Peck A, Lee RS, Hung S, Astle MV, Bywater M, Wall M, Poortinga G, Jastrzebski K, Sheppard KE, Hemmings BA, Hall MN, Johnstone RW, McArthur GA, Hannan RD, Pearson RB
Sci Signal. 2011
PubMed ID: 21878679
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains.
Gao X, Lowry PR, Zhou X, Depry C, Wei Z, Wong GW, Zhang J
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21873248
Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma.
Schatz JH, Oricchio E, Wolfe AL, Jiang M, Linkov I, Maragulia J, Shi W, Zhang Z, Rajasekhar VK, Pagano NC, Porco JA, Teruya-Feldstein J, Rosen N, Zelenetz AD, Pelletier J, Wendel HG
J Exp Med. 2011
PubMed ID: 21859846
Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway.
Cheng YJ, Tsai JW, Hsieh KC, Yang YC, Chen YJ, Huang MS, Yuan SS
Cancer Lett. 2011
PubMed ID: 21536374
Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.
Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA
J Biol Chem. 2011
PubMed ID: 21712384
Dual function of protein kinase C (PKC) in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced manganese superoxide dismutase (MnSOD) expression: activation of CREB and FOXO3a by PKC-alpha phosphorylation and by PKC-mediated inactivation of Akt, respective
Chung YW, Kim HK, Kim IY, Yim MB, Chock PB
J Biol Chem. 2011
PubMed ID: 21705328
Genetic studies of the protein kinase AKT1 in Parkinson's disease.
Ran C, Westerlund M, Anvret A, Willows T, Sydow O, Galter D, Belin AC
Neurosci Lett. 2011
PubMed ID: 21741444
Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway.
Imanishi Y, Hu B, Xiao G, Yao X, Cheng SY
J Biol Chem. 2011
PubMed ID: 21680733
A mosaic activating mutation in AKT1 associated with the Proteus syndrome.
Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, Blumhorst C, Brockmann K, Calder P, Cherman N, Deardorff MA, Everman DB, Golas G, Greenstein RM, Kato BM, Keppler-Noreuil KM, Kuznetsov SA, Miyamoto RT, Newman K, Ng D, O'Brien K, Rothenberg S, Schwartzentruber DJ, Singhal V, Tirabosco R, Upton J, Wientroub S, Zackai EH, Hoag K, Whitewood-Neal T, Robey PG, Schwartzberg PL, Darling TN, Tosi LL, Mullikin JC, Biesecker LG
N Engl J Med. 2011
PubMed ID: 21793738
Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90.
Mehta PP, Whalen P, Baxi SM, Kung PP, Yamazaki S, Yin MJ
Clin Cancer Res. 2011
PubMed ID: 21715568
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Ling YH, Aracil M, Zou Y, Yuan Z, Lu B, Jimeno J, Cuervo AM, Perez-Soler R
Clin Cancer Res. 2011
PubMed ID: 21690574
Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism.
Wu X, Xu K, Zhang L, Deng Y, Lee P, Shapiro E, Monaco M, Makarenkova HP, Li J, Lepor H, Grishina I
Dev Biol. 2011
PubMed ID: 21624358
A switch toward angiostatic gene expression impairs the angiogenic properties of endothelial progenitor cells in low birth weight preterm infants.
Ligi I, Simoncini S, Tellier E, Vassallo PF, Sabatier F, Guillet B, Lamy E, Sarlon G, Quemener C, Bikfalvi A, Marcelli M, Pascal A, Dizier B, Simeoni U, Dignat-George F, Anfosso F
Blood. 2011
PubMed ID: 21659549
Akt phosphorylates and regulates the osteogenic activity of Osterix.
Choi YH, Jeong HM, Jin YH, Li H, Yeo CY, Lee KY
Biochem Biophys Res Commun. 2011
PubMed ID: 21777568
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.
Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T
Blood. 2011
PubMed ID: 21653327
Asymmetric cancer cell division regulated by AKT.
Dey-Guha I, Wolfer A, Yeh AC, G Albeck J, Darp R, Leon E, Wulfkuhle J, Petricoin EF, Wittner BS, Ramaswamy S
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21757645
Beta-HPV 5 and 8 E6 promote p300 degradation by blocking AKT/p300 association.
Howie HL, Koop JI, Weese J, Robinson K, Wipf G, Kim L, Galloway DA
PLoS Pathog. 2011
PubMed ID: 21901101
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells.
Taylor JR, Lehmann BD, Chappell WH, Abrams SL, Steelman LS, McCubrey JA
Oncotarget. 2011
PubMed ID: 21881167
Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling.
Vassiliadis J, Bracken C, Matthews D, O'Brien S, Schiavi S, Wawersik S
J Am Soc Nephrol. 2011
PubMed ID: 21784900
TLR2 ligand induces protection against cerebral ischemia/reperfusion injury via activation of phosphoinositide 3-kinase/Akt signaling.
Lu C, Liu L, Chen Y, Ha T, Kelley J, Schweitzer J, Kalbfleisch JH, Kao RL, Williams DL, Li C
J Immunol. 2011
PubMed ID: 21709150
Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt.
Li X, Yang H, Liu J, Schmidt MD, Gao T
EMBO Rep. 2011
PubMed ID: 21701506
PTEN, pAKT, and pmTOR expression and subcellular distribution in primary renal cell carcinomas and their metastases.
Hager M, Haufe H, Lusuardi L, Schmeller N, Kolbitsch C
Cancer Invest. 2011
PubMed ID: 21696297
Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
Coloff JL, Macintyre AN, Nichols AG, Liu T, Gallo CA, Plas DR, Rathmell JC
Cancer Res. 2011
PubMed ID: 21670080
Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis.
Arms L, Vizzard MA
Am J Physiol Renal Physiol. 2011
PubMed ID: 21632956
Bimodal regulation of FoxO3 by AKT and 14-3-3.
Dobson M, Ramakrishnan G, Ma S, Kaplun L, Balan V, Fridman R, Tzivion G
Biochim Biophys Acta. 2011
PubMed ID: 21621563
AKT down-regulates insulin-like growth factor-1 receptor as a negative feedback.
Qin L, Wang Y, Tao L, Wang Z
J Biochem. 2011
PubMed ID: 21616916
Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells.
Priebe A, Tan L, Wahl H, Kueck A, He G, Kwok R, Opipari A, Liu JR
Gynecol Oncol. 2011
PubMed ID: 21570709
Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis.
Pizon M, Rampanarivo H, Tauzin S, Chaigne-Delalande B, Daburon S, Castroviejo M, Moreau P, Moreau JF, Legembre P
Eur J Immunol. 2011
PubMed ID: 21557211
Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling.
Volling K, Thywissen A, Brakhage AA, Saluz HP
Cell Microbiol. 2011
PubMed ID: 21501368
Involvement of PI3K/Akt/CREB and redox changes in mitochondrial defect of osteoblastic MC3T3-E1 cells.
Choi EM, Lee YS
Toxicol In Vitro. 2011
PubMed ID: 21466842
PI3K/Akt signaling pathway is involved in the pathogenesis of ulcerative colitis.
Huang XL, Xu J, Zhang XH, Qiu BY, Peng L, Zhang M, Gan HT
Inflamm Res. 2011
PubMed ID: 21442372
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
Ohta E, Kawakami F, Kubo M, Obata F
FEBS Lett. 2011
PubMed ID: 21658387
Akt-mediated proinflammatory response of mononuclear phagocytes infected with Burkholderia cenocepacia occurs by a novel GSK3β-dependent, IκB kinase-independent mechanism.
Cremer TJ, Shah P, Cormet-Boyaka E, Valvano MA, Butchar JP, Tridandapani S
J Immunol. 2011
PubMed ID: 21697459
mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].
Moore SF, Hunter RW, Hers I
J Biol Chem. 2011
PubMed ID: 21592956
von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.
Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD
Oncogene. 2011
PubMed ID: 21358672
Nicotinamide attenuates the ischemic brain injury-induced decrease of Akt activation and Bad phosphorylation.
Koh PO
Neurosci Lett. 2011
PubMed ID: 21596097
An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts.
Rybchyn MS, Slater M, Conigrave AD, Mason RS
J Biol Chem. 2011
PubMed ID: 21566129
L-threonine regulates G1/S phase transition of mouse embryonic stem cells via PI3K/Akt, MAPKs, and mTORC pathways.
Ryu JM, Han HJ
J Biol Chem. 2011
PubMed ID: 21550972
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways.
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD
Cell Metab. 2011
PubMed ID: 21723501
Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells.
Wittig-Blaich SM, Kacprzyk LA, Eismann T, Bewerunge-Hudler M, Kruse P, Winkler E, Strauss WS, Hibst R, Steiner R, Schrader M, Mertens D, Sültmann H, Wittig R
Neoplasia. 2011
PubMed ID: 21750652
Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis.
Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
J Immunol. 2011
PubMed ID: 21646299
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy.
Espeillac C, Mitchell C, Celton-Morizur S, Chauvin C, Koka V, Gillet C, Albrecht JH, Desdouets C, Pende M
J Clin Invest. 2011
PubMed ID: 21633171
Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.
Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X
Mol Cell Biol. 2011
PubMed ID: 21576358
Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.
Polytarchou C, Iliopoulos D, Hatziapostolou M, Kottakis F, Maroulakou I, Struhl K, Tsichlis PN
Cancer Res. 2011
PubMed ID: 21555366
Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling.
Voloshenyuk TG, Landesman ES, Khoutorova E, Hart AD, Gardner JD
Cytokine. 2011
PubMed ID: 21498085
Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells.
Kočí L, Hýžd'alová M, Vaculová A, Hofmanová J, Kozubík A
Cytokine. 2011
PubMed ID: 21482133
Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes.
Zhu S, Sun F, Li W, Cao Y, Wang C, Wang Y, Liang D, Zhang R, Zhang S, Wang H, Cao F
Mol Cell Biochem. 2011
PubMed ID: 21461612
Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration.
Kim SR, Chen X, Oo TF, Kareva T, Yarygina O, Wang C, During M, Kholodilov N, Burke RE
Ann Neurol. 2011
PubMed ID: 21437936
Regulation of IGF-1/PI3K/Akt signalling by the phosphoinositide phosphatase pharbin.
Wang F, Ijuin T, Itoh T, Takenawa T
J Biochem. 2011
PubMed ID: 21436142
Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.
Jang ER, Kim YJ, Myung SC, Kim W, Lee CS
Mol Cell Biochem. 2011
PubMed ID: 21380726
Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation.
Peltier J, Conway A, Keung AJ, Schaffer DV
Stem Cells Dev. 2011
PubMed ID: 21028992
Serotonin activates MAP kinase and PI3K/Akt signaling pathways in prostate cancer cell lines.
Dizeyi N, Hedlund P, Bjartell A, Tinzl M, Austild-Taskén K, Abrahamsson PA
Urol Oncol. 2011
PubMed ID: 19926313
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis.
Kim EK, Yun SJ, Ha JM, Kim YW, Jin IH, Yun J, Shin HK, Song SH, Kim JH, Lee JS, Kim CD, Bae SS
Oncogene. 2011
PubMed ID: 21339740
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN).
Numajiri N, Takasawa K, Nishiya T, Tanaka H, Ohno K, Hayakawa W, Asada M, Matsuda H, Azumi K, Kamata H, Nakamura T, Hara H, Minami M, Lipton SA, Uehara T
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21646525
Akt phosphorylates and regulates the function of Dlx5.
Jeong HM, Jin YH, Kim YJ, Yum J, Choi YH, Yeo CY, Lee KY
Biochem Biophys Res Commun. 2011
PubMed ID: 21619873
GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.
Elsawa SF, Almada LL, Ziesmer SC, Novak AJ, Witzig TE, Ansell SM, Fernandez-Zapico ME
J Biol Chem. 2011
PubMed ID: 21454528
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression.
Lau MT, Klausen C, Leung PC
Oncogene. 2011
PubMed ID: 21297666
Nonredundant functions for Akt isoforms in astrocyte growth and gliomagenesis in an orthotopic transplantation model.
Endersby R, Zhu X, Hay N, Ellison DW, Baker SJ
Cancer Res. 2011
PubMed ID: 21507933
Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells.
Huang WC, Chen YJ, Li LY, Wei YL, Hsu SC, Tsai SL, Chiu PC, Huang WP, Wang YN, Chen CH, Chang WC, Chang WC, Chen AJ, Tsai CH, Hung MC
J Biol Chem. 2011
PubMed ID: 21487020
Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells.
Koide M, Ikeda K, Akakabe Y, Kitamura Y, Ueyama T, Matoba S, Yamada H, Okigaki M, Matsubara H
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21593423
Myotubularin regulates Akt-dependent survival signaling via phosphatidylinositol 3-phosphate.
Razidlo GL, Katafiasz D, Taylor GS
J Biol Chem. 2011
PubMed ID: 21478156
Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC, Newton AC
J Biol Chem. 2011
PubMed ID: 21454620
Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder.
Sun CH, Chang YH, Pan CC
Histopathology. 2011
PubMed ID: 21707707
Protein kinase B/Akt may regulate G2/M transition in the fertilized mouse egg by changing the localization of p21(Cip1/WAF1).
Wu DD, Feng C, Xu XY, Xiao JY, Liu C, Meng J, Wang EH, Yu BZ
Cell Biochem Funct. 2011
PubMed ID: 21671244
Phosphorylation of AKT: a mutational analysis.
Hart JR, Vogt PK
Oncotarget. 2011
PubMed ID: 21670491
Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors.
Fallah MP, Chelvarajan RL, Garvy BA, Bondada S
Mech Ageing Dev. 2011
PubMed ID: 21645538
Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.
D'Souza AD, Parish IA, McKay SE, Kaech SM, Shadel GS
Am J Pathol. 2011
PubMed ID: 21641396
In situ phosphorylation of Akt and ERK1/2 in rat mammary gland, colon, and liver following treatment with human insulin and IGF-1.
Hvid H, Fels JJ, Kirk RK, Thorup I, Jensen HE, Hansen BF, Oleksiewicz MB
Toxicol Pathol. 2011
PubMed ID: 21558470
Differences in myocardial PTEN expression and Akt signalling in type 2 diabetic and nondiabetic patients undergoing coronary bypass surgery.
Wang B, Raedschelders K, Shravah J, Hui Y, Safaei HG, Chen DD, Cook RC, Fradet G, Au CL, Ansley DM
Clin Endocrinol (Oxf). 2011
PubMed ID: 21521253
The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.
Malagarie-Cazenave S, Olea-Herrero N, Vara D, Morell C, Díaz-Laviada I
Cytokine. 2011
PubMed ID: 21474332
The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress.
Sanghera KP, Mathalone N, Baigi R, Panov E, Wang D, Zhao X, Hsu H, Wang H, Tropepe V, Ward M, Boyd SR
Mol Cell Neurosci. 2011
PubMed ID: 21463685
RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac.
Huang M, Satchell L, Duhadaway JB, Prendergast GC, Laury-Kleintop LD
J Cell Biochem. 2011
PubMed ID: 21344485
Akt/protein B and estradiol receptor alpha expressions in postmenopausal endometrium.
Wilhelm F, Kovács KA, Lengyel F, Menyhart C, Vizer MG, Vértes M, Szabó I
Eur J Obstet Gynecol Reprod Biol. 2011
PubMed ID: 21295396
Mild stretch activates cPLA2 in alveolar type II epithelial cells independently through the MEK/ERK and PI3K pathways.
Letsiou E, Kitsiouli E, Nakos G, Lekka ME
Biochim Biophys Acta. 2011
PubMed ID: 21185392
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse m
Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J
J Biol Chem. 2011
PubMed ID: 21460223
Targeting the Akt/mTOR pathway in Brca1-deficient cancers.
Xiang T, Jia Y, Sherris D, Li S, Wang H, Lu D, Yang Q
Oncogene. 2011
PubMed ID: 21242970
Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor.
Woldt E, Matz RL, Terrand J, Mlih M, Gracia C, Foppolo S, Martin S, Bruban V, Ji J, Velot E, Herz J, Boucher P
J Biol Chem. 2011
PubMed ID: 21454706
The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.
Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T
Circ Res. 2011
PubMed ID: 21415395
Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin co
Martin J, Masri J, Cloninger C, Holmes B, Artinian N, Funk A, Ruegg T, Anderson L, Bashir T, Bernath A, Lichtenstein A, Gera J
J Biol Chem. 2011
PubMed ID: 21454539
Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus.
Cao R, Anderson FE, Jung YJ, Dziema H, Obrietan K
Neuroscience. 2011
PubMed ID: 21382453
[Effects of PI3K/Akt signaling pathway on learning and memory abilities in neonatal rats with hypoxic-ischemic brain damage].
Yao D, He X, Wang JH, Zhao ZY
Zhongguo Dang Dai Er Ke Za Zhi. 2011
PubMed ID: 21575352
Hepatocyte growth factor inhibits anoikis of pancreatic carcinoma cells through phosphatidylinositol 3-kinase pathway.
Watanabe S, Kishimoto T, Yokosuka O
Pancreas. 2011
PubMed ID: 21499215
PKB/SGK-resistant GSK3 enhances phosphaturia and calciuria.
Föller M, Kempe DS, Boini KM, Pathare G, Siraskar B, Capuano P, Alesutan I, Sopjani M, Stange G, Mohebbi N, Bhandaru M, Ackermann TF, Judenhofer MS, Pichler BJ, Biber J, Wagner CA, Lang F
J Am Soc Nephrol. 2011
PubMed ID: 21493770
Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration.
Yadav V, Denning MF
Mol Carcinog. 2011
PubMed ID: 21480388
Knockdown of STEAP4 inhibits insulin-stimulated glucose transport and GLUT4 translocation via attenuated phosphorylation of Akt, independent of the effects of EEA1.
Cheng R, Qiu J, Zhou XY, Chen XH, Zhu C, Qin DN, Wang JW, Ni YH, Ji CB, Guo XR
Mol Med Report. 2011
PubMed ID: 21468601
The phosphatidylinositol 3' kinase-Akt-mammalian target of rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and their clinicopathologic implications.
Fadare O, Renshaw I, Olson SJ, Liang SX
Int J Gynecol Pathol. 2011
PubMed ID: 21464729
Akt1 and Akt2: differentiating the aktion.
Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ
Histol Histopathol. 2011
PubMed ID: 21432781
Genetic polymorphisms in inflammation pathway genes and prostate cancer risk.
Kwon EM, Salinas CA, Kolb S, Fu R, Feng Z, Stanford JL, Ostrander EA
Cancer Epidemiol Biomarkers Prev. 2011
PubMed ID: 21430300
Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.
De Salvo M, Maresca G, D'agnano I, Marchese R, Stigliano A, Gagliassi R, Brunetti E, Raza GH, De Paula U, Bucci B
Int J Radiat Biol. 2011
PubMed ID: 21405945
Genetic suppression of Akt1 activity aggravates cerebral ischemia/reperfusion injury after deep hypothermic low flow in transgenic mice.
Ma Z, Mo X, Yang Z, Chen F, He X
Eur J Pediatr Surg. 2011
PubMed ID: 21351045
Lack of compensatory pAKT activation and eIF4E phosphorylation of lymphoma cells towards mTOR inhibitor, RAD001.
Kuo SH, Hsu CH, Chen LT, Lu YS, Lin CH, Yeh PY, Jeng HJ, Gao M, Yeh KH, Cheng AL
Eur J Cancer. 2011
PubMed ID: 21334199
Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.
Joo HM, Kim JY, Jeong JB, Seong KM, Nam SY, Yang KH, Kim CS, Kim HS, Jeong M, An S, Jin YW
Eur J Cell Biol. 2011
PubMed ID: 21333377
Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression.
Kwiatkowska A, Kijewska M, Lipko M, Hibner U, Kaminska B
Biochim Biophys Acta. 2011
PubMed ID: 21276823
Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B.
Hashiramoto A, Murata M, Kawazoe T, Yoshida K, Akiyama C, Shiozawa K, Shiozawa S
Rheumatology (Oxford). 2011
PubMed ID: 21177334
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
Nechemia-Arbely Y, Shriki A, Denz U, Drucker C, Scheller J, Raub J, Pappo O, Rose-John S, Galun E, Axelrod JH
J Hepatol. 2011
PubMed ID: 21145830
The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton.
Kawai M, Breggia AC, DeMambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ
J Biol Chem. 2011
PubMed ID: 21372140
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.
Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM, Su B
J Biol Chem. 2011
PubMed ID: 21321111
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21464312
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.
Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21464307
Discovery and SAR of spirochromane Akt inhibitors.
Kallan NC, Spencer KL, Blake JF, Xu R, Heizer J, Bencsik JR, Mitchell IS, Gloor SL, Martinson M, Risom T, Gross SD, Morales TH, Wu WI, Vigers GP, Brandhuber BJ, Skelton NJ
Bioorg Med Chem Lett. 2011
PubMed ID: 21392984
Cardiac progenitor cell commitment is inhibited by nuclear Akt expression.
Fischer KM, Din S, Gude N, Konstandin MH, Wu W, Quijada P, Sussman MA
Circ Res. 2011
PubMed ID: 21350213
Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling.
Kolegraff K, Nava P, Helms MN, Parkos CA, Nusrat A
Mol Biol Cell. 2011
PubMed ID: 21325624
Negative regulation of mTOR activation by diacylglycerol kinases.
Gorentla BK, Wan CK, Zhong XP
Blood. 2011
PubMed ID: 21310925
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA
Oncogene. 2011
PubMed ID: 21242979
Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.
Sakamaki J, Daitoku H, Ueno K, Hagiwara A, Yamagata K, Fukamizu A
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21444773
Adiponectin inhibits osteoclastogenesis and bone resorption via APPL1-mediated suppression of Akt1.
Tu Q, Zhang J, Dong LQ, Saunders E, Luo E, Tang J, Chen J
J Biol Chem. 2011
PubMed ID: 21300805
Effect of eccentric exercise velocity on akt/mtor/p70(s6k) signaling in human skeletal muscle.
Roschel H, Ugrinowistch C, Barroso R, Batista MA, Souza EO, Aoki MS, Siqueira-Filho MA, Zanuto R, Carvalho CR, Neves M, Mello MT, Tricoli V
Appl Physiol Nutr Metab. 2011
PubMed ID: 21609291
[The effect of exogenous glial cell line-derived neurotrophic factor on expression of gastric and colonic Akt, MAPK in slow transit constipation rats].
Fan YH, Zhang GS, Li YL, Zhang L, Lü B
Zhonghua Nei Ke Za Zhi. 2011
PubMed ID: 21600154
Evidence for the role of PI(3) -kinase-AKT-eNOS signalling pathway in secondary inflammatory process after spinal cord compression injury in mice.
Paterniti I, Esposito E, Mazzon E, Bramanti P, Cuzzocrea S
Eur J Neurosci. 2011
PubMed ID: 21496122
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.
Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC
Nat Cell Biol. 2011
PubMed ID: 21441927
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N
Development. 2011
PubMed ID: 21367821
Rheb is essential for murine development.
Goorden SM, Hoogeveen-Westerveld M, Cheng C, van Woerden GM, Mozaffari M, Post L, Duckers HJ, Nellist M, Elgersma Y
Mol Cell Biol. 2011
PubMed ID: 21321084
Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.
López-Juárez A, Morales-Lázaro S, Sánchez-Sánchez R, Sunkara M, Lomelí H, Velasco I, Morris AJ, Escalante-Alcalde D
Glia. 2011
PubMed ID: 21319224
Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
Thayyullathil F, Chathoth S, Shahin A, Kizhakkayil J, Hago A, Patel M, Galadari S
J Cell Biochem. 2011
PubMed ID: 21308747
Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma.
Tsubaki M, Yamazoe Y, Yanae M, Satou T, Itoh T, Kaneko J, Kidera Y, Moriyama K, Nishida S
Cytokine. 2011
PubMed ID: 21292498
TGF-beta1-induced PI3K/Akt/NF-kappaB/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblasts.
Zhu X, Wang L, Zhang B, Li J, Dou X, Zhao RC
J Biochem. 2011
PubMed ID: 21288887
Ghrelin suppression of Helicobacter pylori-induced S-nitrosylation-dependent Akt inactivation exerts modulatory influence on gastric mucin synthesis.
Slomiany BL, Slomiany A
Inflammopharmacology. 2011
PubMed ID: 21279549
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
Arora D, Stopp S, Böhmer SA, Schons J, Godfrey R, Masson K, Razumovskaya E, Rönnstrand L, Tänzer S, Bauer R, Böhmer FD, Müller JP
J Biol Chem. 2011
PubMed ID: 21262971
Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.
Antoniv TT, Ivashkiv LB
Immunology. 2011
PubMed ID: 21255011
Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice.
Kim MH, Kay DI, Rudra RT, Chen BM, Hsu N, Izumiya Y, Martinez L, Spencer MJ, Walsh K, Grinnell AD, Crosbie RH
Hum Mol Genet. 2011
PubMed ID: 21245083
Lens induction requires attenuation of ERK signaling by Nf1.
Carbe C, Zhang X
Hum Mol Genet. 2011
PubMed ID: 21233129
Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins.
Yoshimi A, Goyama S, Watanabe-Okochi N, Yoshiki Y, Nannya Y, Nitta E, Arai S, Sato T, Shimabe M, Nakagawa M, Imai Y, Kitamura T, Kurokawa M
Blood. 2011
PubMed ID: 21289308
Phosphatidylserine is a critical modulator for Akt activation.
Huang BX, Akbar M, Kevala K, Kim HY
J Cell Biol. 2011
PubMed ID: 21402788
RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway.
Wang F, Yamauchi M, Muramatsu M, Osawa T, Tsuchida R, Shibuya M
J Biol Chem. 2011
PubMed ID: 21212275
Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampus.
Yildirim M, Janssen WG, Lou WY, Akama KT, McEwen BS, Milner TA, Morrison JH
Brain Res. 2011
PubMed ID: 20709039
Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 inhibition in breast cancer.
Gonzalez ME, DuPrie ML, Krueger H, Merajver SD, Ventura AC, Toy KA, Kleer CG
Cancer Res. 2011
PubMed ID: 21406404
PrLZ protects prostate cancer cells from apoptosis induced by androgen deprivation via the activation of Stat3/Bcl-2 pathway.
Zhang D, He D, Xue Y, Wang R, Wu K, Xie H, Zeng J, Wang X, Zhau HE, Chung LW, Chang LS, Li L
Cancer Res. 2011
PubMed ID: 21385902
OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling.
So T, Choi H, Croft M
J Immunol. 2011
PubMed ID: 21289304
Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.
Ricciardi S, Boggio EM, Grosso S, Lonetti G, Forlani G, Stefanelli G, Calcagno E, Morello N, Landsberger N, Biffo S, Pizzorusso T, Giustetto M, Broccoli V
Hum Mol Genet. 2011
PubMed ID: 21212100
Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin.
Zhang J, Fukuhara S, Sako K, Takenouchi T, Kitani H, Kume T, Koh GY, Mochizuki N
J Biol Chem. 2011
PubMed ID: 21212269
NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox.
Edderkaoui M, Nitsche C, Zheng L, Pandol SJ, Gukovsky I, Gukovskaya AS
J Biol Chem. 2011
PubMed ID: 21118808
A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2.
Murata H, Sakaguchi M, Jin Y, Sakaguchi Y, Futami J, Yamada H, Kataoka K, Huh NH
J Biol Chem. 2011
PubMed ID: 21177249
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.
Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY
J Clin Invest. 2011
PubMed ID: 21393858
Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways.
Xiang Y, Li Q, Li M, Wang W, Cui C, Zhang J
Cell Biochem Funct. 2011
PubMed ID: 21370247
Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase.
Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, Abe T, Vavvas D, Miller JW
Am J Pathol. 2011
PubMed ID: 21356360
Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.
Cheng CJ, Huang CL
J Am Soc Nephrol. 2011
PubMed ID: 21355052
An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons.
Majumdar D, Nebhan CA, Hu L, Anderson B, Webb DJ
Mol Cell Neurosci. 2011
PubMed ID: 21236345
Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.
Wagner MJ, Smiley JR
J Virol. 2011
PubMed ID: 21228233
Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis.
Wang S, Basson MD
Am J Physiol Cell Physiol. 2011
PubMed ID: 21209368
Increased Akt-mTOR signaling in lung epithelium is associated with respiratory distress syndrome in mice.
Ikeda H, Shiojima I, Oka T, Yoshida M, Maemura K, Walsh K, Igarashi T, Komuro I
Mol Cell Biol. 2011
PubMed ID: 21189286
PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma.
Rodriguez EF, Scheithauer BW, Giannini C, Rynearson A, Cen L, Hoesley B, Gilmer-Flynn H, Sarkaria JN, Jenkins S, Long J, Rodriguez FJ
Acta Neuropathol. 2011
PubMed ID: 21113787
Survival and size are differentially regulated by placental and fetal PKBalpha/AKT1 in mice.
Plaks V, Berkovitz E, Vandoorne K, Berkutzki T, Damari GM, Haffner R, Dekel N, Hemmings BA, Neeman M, Harmelin A
Biol Reprod. 2011
PubMed ID: 20980686
H2S protects hippocampal neurons from anoxia-reoxygenation through cAMP-mediated PI3K/Akt/p70S6K cell-survival signaling pathways.
Shao JL, Wan XH, Chen Y, Bi C, Chen HM, Zhong Y, Heng XH, Qian JQ
J Mol Neurosci. 2011
PubMed ID: 20967511
Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K-Akt pathways.
Prasad SS, Russell M, Nowakowska M
J Mol Neurosci. 2011
PubMed ID: 20953735
Fibroblast growth factor-2 stimulates directed migration of periodontal ligament cells via PI3K/AKT signaling and CD44/hyaluronan interaction.
Shimabukuro Y, Terashima H, Takedachi M, Maeda K, Nakamura T, Sawada K, Kobashi M, Awata T, Oohara H, Kawahara T, Iwayama T, Hashikawa T, Yanagita M, Yamada S, Murakami S
J Cell Physiol. 2011
PubMed ID: 20857427
Caffeine modulates tau phosphorylation and affects Akt signaling in postmitotic neurons.
Currais A, Kato K, Canuet L, Ishii R, Tanaka T, Takeda M, Soriano S
J Mol Neurosci. 2011
PubMed ID: 20838929
Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.
He X, Wang Y, Zhu J, Orloff M, Eng C
Cancer Lett. 2011
PubMed ID: 21168265
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Macintyre AN, Finlay D, Preston G, Sinclair LV, Waugh CM, Tamas P, Feijoo C, Okkenhaug K, Cantrell DA
Immunity. 2011
PubMed ID: 21295499
Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling.
Tato I, Bartrons R, Ventura F, Rosa JL
J Biol Chem. 2011
PubMed ID: 21131356
PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation.
Deng R, Tang J, Ma JG, Chen SP, Xia LP, Zhou WJ, Li DD, Feng GK, Zeng YX, Zhu XF
Oncogene. 2011
PubMed ID: 20956948
Campylobacter jejuni induces an anti-inflammatory response in human intestinal epithelial cells through activation of phosphatidylinositol 3-kinase/Akt pathway.
Li YP, Vegge CS, Brøndsted L, Madsen M, Ingmer H, Bang DD
Vet Microbiol. 2011
PubMed ID: 20863633
Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.
Rodgers JT, Vogel RO, Puigserver P
Mol Cell. 2011
PubMed ID: 21329884
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC
J Biol Chem. 2011
PubMed ID: 21159778
Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.
Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes P
Mol Biol Cell. 2011
PubMed ID: 21169559
Macrophage-induced preadipocyte survival depends on signaling through Akt, ERK1/2, and reactive oxygen species.
Molgat AS, Gagnon A, Sorisky A
Exp Cell Res. 2011
PubMed ID: 21056559
Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.
Chen YW, Lai WS
Neuroscience. 2011
PubMed ID: 20888398
New driver mutations in non-small-cell lung cancer.
Pao W, Girard N
Lancet Oncol. 2011
PubMed ID: 21277552
ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks.
Khalil A, Morgan RN, Adams BR, Golding SE, Dever SM, Rosenberg E, Povirk LF, Valerie K
Cell Cycle. 2011
PubMed ID: 21263216
bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells.
Farrell SM, Groeger G, Bhatt L, Finnegan S, O'Brien CJ, Cotter TG
Eur J Neurosci. 2011
PubMed ID: 21219477
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.
Long YC, Cheng Z, Copps KD, White MF
Mol Cell Biol. 2011
PubMed ID: 21135130
Electrostimulation during hindlimb unloading modulates PI3K-AKT downstream targets without preventing soleus atrophy and restores slow phenotype through ERK.
Dupont E, Cieniewski-Bernard C, Bastide B, Stevens L
Am J Physiol Regul Integr Comp Physiol. 2011
PubMed ID: 21106911
Endometrial cancer and genetic variation in PTEN, PIK3CA, AKT1, MLH1, and MSH2 within a population-based case-control study.
Lacey JV, Yang H, Gaudet MM, Dunning A, Lissowska J, Sherman ME, Peplonska B, Brinton LA, Healey CS, Ahmed S, Pharoah P, Easton D, Chanock S, Garcia-Closas M
Gynecol Oncol. 2011
PubMed ID: 21093899
Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells.
Memon AA, Munk M, Nexo E, Sorensen BS
Scand J Clin Lab Invest. 2011
PubMed ID: 21087080
Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas.
Dobashi Y, Suzuki S, Kimura M, Matsubara H, Tsubochi H, Imoto I, Ooi A
Hum Pathol. 2011
PubMed ID: 21040950
Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity.
Li CJ, Chang JK, Wang GJ, Ho ML
Bone. 2011
PubMed ID: 20854947
E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth.
Srinivasan S, Nawaz Z
Biochim Biophys Acta. 2011
PubMed ID: 20826237
Role of hypoxia-induced fibronectin-integrin β1 expression in embryonic stem cell proliferation and migration: Involvement of PI3K/Akt and FAK.
Lee SH, Lee YJ, Han HJ
J Cell Physiol. 2011
PubMed ID: 20677223
αVβ3 integrin regulates macrophage inflammatory responses via PI3 kinase/Akt-dependent NF-κB activation.
Antonov AS, Antonova GN, Munn DH, Mivechi N, Lucas R, Catravas JD, Verin AD
J Cell Physiol. 2011
PubMed ID: 20672329
Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis.
Redlak MJ, Miller TA
Dig Dis Sci. 2011
PubMed ID: 20585984
Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes.
Nazarewicz RR, Salazar G, Patrushev N, San Martin A, Hilenski L, Xiong S, Alexander RW
J Biol Chem. 2011
PubMed ID: 21097843
Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon development.
Cheng PL, Lu H, Shelly M, Gao H, Poo MM
Neuron. 2011
PubMed ID: 21262463
Vimentin is a novel AKT1 target mediating motility and invasion.
Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D
Oncogene. 2011
PubMed ID: 20856200
Rheb1 is required for mTORC1 and myelination in postnatal brain development.
Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B
Dev Cell. 2011
PubMed ID: 21238928
The role of glycogen synthase kinase 3 in regulating IFN-β-mediated IL-10 production.
Wang H, Brown J, Garcia CA, Tang Y, Benakanakere MR, Greenway T, Alard P, Kinane DF, Martin M
J Immunol. 2011
PubMed ID: 21160051
A role for immature myeloid cells in immune senescence.
Enioutina EY, Bareyan D, Daynes RA
J Immunol. 2011
PubMed ID: 21148798
Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.
Zhang HS, Sang WW, Ruan Z, Wang YO
Arch Biochem Biophys. 2011
PubMed ID: 21029719
Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.
Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S, Miyazaki T
J Clin Invest. 2011
PubMed ID: 21135503
Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways.
Rashid A, Liu C, Sanli T, Tsiani E, Singh G, Bristow RG, Dayes I, Lukka H, Wright J, Tsakiridis T
Radiat Oncol. 2011
PubMed ID: 22029423
A regulatory mechanism involving TBP-1/Tat-Binding Protein 1 and Akt/PKB in the control of cell proliferation.
Sepe M, Festa L, Tolino F, Bellucci L, Sisto L, Alfano D, Ragno P, Calabrò V, de Franciscis V, La Mantia G, Pollice A
PLoS One. 2011
PubMed ID: 21991300
Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins.
Hutz JE, Manning WA, Province MA, McLeod HL
PLoS One. 2011
PubMed ID: 21949775
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
LaRocca J, Pietruska J, Hixon M
PLoS One. 2011
PubMed ID: 21915327
SOD3 decreases ischemic injury derived apoptosis through phosphorylation of Erk1/2, Akt, and FoxO3a.
Laatikainen LE, Incoronato M, Castellone MD, Laurila JP, Santoro M, Laukkanen MO
PLoS One. 2011
PubMed ID: 21909393
Critical role of PI3K/Akt/GSK3β in motoneuron specification from human neural stem cells in response to FGF2 and EGF.
Ojeda L, Gao J, Hooten KG, Wang E, Thonhoff JR, Dunn TJ, Gao T, Wu P
PLoS One. 2011
PubMed ID: 21887250
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Sundaresan NR, Pillai VB, Wolfgeher D, Samant S, Vasudevan P, Parekh V, Raghuraman H, Cunningham JM, Gupta M, Gupta MP
Sci Signal. 2011
PubMed ID: 21775285
Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development.
Vesterlund L, Töhönen V, Hovatta O, Kere J
Int J Dev Biol. 2011
PubMed ID: 21710437
SHP-2 promotes the maturation of oligodendrocyte precursor cells through Akt and ERK1/2 signaling in vitro.
Liu X, Li Y, Zhang Y, Lu Y, Guo W, Liu P, Zhou J, Xiang Z, He C
PLoS One. 2011
PubMed ID: 21701583
Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival.
Shimada K, Anai S, Marco DA, Fujimoto K, Konishi N
BMC Urol. 2011
PubMed ID: 21592330
IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways.
Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A
Nat Commun. 2011
PubMed ID: 21587235
Anti-bacterial effects of poly-N-acetyl-glucosamine nanofibers in cutaneous wound healing: requirement for Akt1.
Lindner HB, Zhang A, Eldridge J, Demcheva M, Tsichilis P, Seth A, Vournakis J, Muise-Helmericks RC
PLoS One. 2011
PubMed ID: 21559496
Acute modulation of vasoconstrictor responses by pravastatin in small vessels.
Ghaffari N, Ball C, Kennedy JA, Stafford I, Beltrame JF
Circ J. 2011
PubMed ID: 21532183
Inhibition of Akt (ser473) phosphorylation and rapamycin-resistant cell growth by knockdown of mammalian target of rapamycin with small interfering RNA in vascular endothelial growth factor receptor-1-targeting vector.
Koide H, Asai T, Furuya K, Tsuzuku T, Kato H, Dewa T, Nango M, Maeda N, Oku N
Biol Pharm Bull. 2011
PubMed ID: 21532145
Cell-type-specific regulation of raft-associated Akt signaling.
Liu Y, Yang G, Bu X, Liu G, Ding J, Li P, Jia W
Cell Death Dis. 2011
PubMed ID: 21490677
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner.
Yung HW, Charnock-Jones DS, Burton GJ
PLoS One. 2011
PubMed ID: 21445305
TGF-β inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways.
Cicek M, Vrabel A, Sturchio C, Pederson L, Hawse JR, Subramaniam M, Spelsberg TC, Oursler MJ
PLoS One. 2011
PubMed ID: 21423731
Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas.
Stankiewicz E, Prowse DM, Ng M, Cuzick J, Mesher D, Hiscock F, Lu YJ, Watkin N, Corbishley C, Lam W, Berney DM
PLoS One. 2011
PubMed ID: 21407808
MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.
Clegg NJ, Couto SS, Wongvipat J, Hieronymus H, Carver BS, Taylor BS, Ellwood-Yen K, Gerald WL, Sander C, Sawyers CL
PLoS One. 2011
PubMed ID: 21394210
Wnt/β-catenin signaling regulates MAPK and Akt1 expression and growth of hepatocellular carcinoma cells.
Wang XH, Meng XW, Sun X, Liu BR, Han MZ, DU YJ, Song YY, Xu W
Neoplasma. 2011
PubMed ID: 21391741
p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.
Li Y, Tollefsbol TO
PLoS One. 2011
PubMed ID: 21390332
ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated phosphorylation of rictor.
Chen CH, Shaikenov T, Peterson TR, Aimbetov R, Bissenbaev AK, Lee SW, Wu J, Lin HK, Sarbassov dos D
Sci Signal. 2011
PubMed ID: 21343617
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.
Thomas B, Mandir AS, West N, Liu Y, Andrabi SA, Stirling W, Dawson VL, Dawson TM, Lee MK
PLoS One. 2011
PubMed ID: 21304957
The effect of leucine restriction on Akt/mTOR signaling in breast cancer cell lines in vitro and in vivo.
Singh G, Akcakanat A, Sharma C, Luyimbazi D, Naff KA, Meric-Bernstam F
Nutr Cancer. 2011
PubMed ID: 21294052
Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters.
Li J, Zhou BP
BMC Cancer. 2011
PubMed ID: 21284870
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways.
Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY
Hepatology. 2011
PubMed ID: 21254169
PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.
Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ
PLoS One. 2011
PubMed ID: 21253589
Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells.
Nowicki TS, Zhao H, Darzynkiewicz Z, Moscatello A, Shin E, Schantz S, Tiwari RK, Geliebter J
Cell Cycle. 2011
PubMed ID: 21191179
Long-term swimming exercise does not modulate the Akt-dependent endothelial nitric oxide synthase phosphorylation in healthy mice.
Pellegrin M, Miguet-Alfonsi C, Berthelot A, Mazzolai L, Laurant P
Can J Physiol Pharmacol. 2011
PubMed ID: 21186380
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
Estève PO, Chang Y, Samaranayake M, Upadhyay AK, Horton JR, Feehery GR, Cheng X, Pradhan S
Nat Struct Mol Biol. 2011
PubMed ID: 21151116
AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation.
Vartanian R, Masri J, Martin J, Cloninger C, Holmes B, Artinian N, Funk A, Ruegg T, Gera J
Mol Cancer Res. 2011
PubMed ID: 21135252
Recent development of anticancer therapeutics targeting Akt.
Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, Zhang S
Recent Pat Anticancer Drug Discov. 2011
PubMed ID: 21110830
Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1.
Joung SM, Park ZY, Rani S, Takeuchi O, Akira S, Lee JY
J Immunol. 2011
PubMed ID: 21106850
Akt cross-links IL-4 priming, stem cell factor signaling, and IgE-dependent activation in mature human mast cells.
Feuser K, Feilhauer K, Staib L, Bischoff SC, Lorentz A
Mol Immunol. 2011
PubMed ID: 21106245
Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion.
Breivik L, Helgeland E, Aarnes EK, Mrdalj J, Jonassen AK
Basic Res Cardiol. 2011
PubMed ID: 21103992
Deciphering the signaling pathways of cancer stem cells of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways.
Jhanwar-Uniyal M, Albert L, McKenna E, Karsy M, Rajdev P, Braun A, Murali R
Adv Enzyme Regul. 2011
PubMed ID: 21035497
Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus.
Dunn EF, Connor JH
J Virol. 2011
PubMed ID: 20980511
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance.
Wullschleger S, Sakamoto K, Johnstone L, Duce S, Fleming S, Alessi DR
Dis Model Mech. 2011
PubMed ID: 20959631
Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil.
Santos-Ahmed J, Brown C, Smith SD, Weston P, Rasoulpour T, Gilbert ME, Hixon ML
Reprod Toxicol. 2011
PubMed ID: 20951798
Prenatal hypoxia independent of undernutrition promotes molecular markers of insulin resistance in adult offspring.
Camm EJ, Martin-Gronert MS, Wright NL, Hansell JA, Ozanne SE, Giussani DA
FASEB J. 2011
PubMed ID: 20923964
Growth factor receptors gene expression and Akt phosphorylation in benign human thyroid nodules are unaffected by chronic thyrotropin suppression.
Sponziello ML, Bruno R, Durante C, D'Agostino M, Corradino R, Giannasio P, Ciociola E, Ferretti E, Maranghi M, Verrienti A, De Toma G, Filetti S, Russo D
Horm Metab Res. 2011
PubMed ID: 20886414
Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis.
Sury MD, Vorlet-Fawer L, Agarinis C, Yousefi S, Grandgirard D, Leib SL, Christen S
Neurobiol Dis. 2011
PubMed ID: 20875857
Cardioprotection by ischemic postconditioning is abolished in depressed rats: role of Akt and signal transducer and activator of transcription-3.
Zhuo C, Wang Y, Wang X, Wang Y, Chen Y
Mol Cell Biochem. 2011
PubMed ID: 20830508
IGF-1 reduces BACE-1 expression in PC12 cells via activation of PI3-K/Akt and MAPK/ERK1/2 signaling pathways.
Zhang H, Gao Y, Dai Z, Meng T, Tu S, Yan Y
Neurochem Res. 2011
PubMed ID: 20821260
Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.
Yang W, Ju JH, Lee KM, Shin I
Cell Signal. 2011
PubMed ID: 20688159
SDF-1α inhibits hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells through PI3K/Akt and ERK1/2 signaling pathways.
Yin Q, Jin P, Liu X, Wei H, Lin X, Chi C, Liu Y, Sun C, Wei Y
Mol Biol Rep. 2011
PubMed ID: 20383584
The relationship among neuregulin 1-stimulated phosphorylation of AKT, psychosis proneness, and habituation of arousal in nonclinical individuals.
Kéri S, Seres I, Kelemen O, Benedek G
Schizophr Bull. 2011
PubMed ID: 19549627
Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats.
Han JW, Zhan XR, Li XY, Xia B, Wang YY, Zhang J, Li BX
World J Gastroenterol. 2010
PubMed ID: 21182226
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
Su SC, Maxwell SA, Bayless KJ
J Biol Chem. 2010
PubMed ID: 20947498
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers.
Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21127264
Insulin-like growth factor 1 receptor antibody induces rhabdomyosarcoma cell death via a process involving AKT and Bcl-x(L).
Mayeenuddin LH, Yu Y, Kang Z, Helman LJ, Cao L
Oncogene. 2010
PubMed ID: 20818434
AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers.
Guirouilh-Barbat JK, Wilhelm T, Lopez BS
Oncotarget. 2010
PubMed ID: 21321378
Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.
Lodyga M, Bai XH, Kapus A, Liu M
J Cell Sci. 2010
PubMed ID: 21084565
Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Krüppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation.
Ganguly S, Basu B, Shome S, Jadhav T, Roy S, Majumdar J, Dasgupta PS, Basu S
Am J Pathol. 2010
PubMed ID: 21075859
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E
EMBO J. 2010
PubMed ID: 21045808
Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest.
Mikami I, Zhang F, Hirata T, Okamoto J, Koizumi K, Shimizu K, Jablons D, He B
Oncol Rep. 2010
PubMed ID: 21042767
Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt, JNK and ERK activation.
Feng Y, Huang J, Ding Y, Xie F, Shen X
Oncol Rep. 2010
PubMed ID: 21042752
Regulation of mutual inhibitory activities between AMPK and Akt with quercetin in MCF-7 breast cancer cells.
Lee YK, Park OJ
Oncol Rep. 2010
PubMed ID: 21042744
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
J Clin Invest. 2010
PubMed ID: 21041952
Activation of phosphatidylinositol 3-kinase/Akt and impairment of nuclear factor-kappaB: molecular mechanisms behind the arrested maturation/activation state of Leishmania infantum-infected dendritic cells.
Neves BM, Silvestre R, Resende M, Ouaissi A, Cunha J, Tavares J, Loureiro I, Santarém N, Silva AM, Lopes MC, Cruz MT, Cordeiro da Silva A
Am J Pathol. 2010
PubMed ID: 21037075
Functional characterization of a haplotype in the AKT1 gene associated with glucose homeostasis and metabolic syndrome.
Harmon BT, Devaney SA, Gordish-Dressman H, Reeves EK, Zhao P, Devaney JM, Hoffman EP
Hum Genet. 2010
PubMed ID: 20872231
Decidual PTEN expression is required for trophoblast invasion in the mouse.
Laguë MN, Detmar J, Paquet M, Boyer A, Richards JS, Adamson SL, Boerboom D
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20858757
p-AKT overexpression in primary renal cell carcinomas and their metastases.
Hager M, Haufe H, Lusuardi L, Schmeller N, Kolbitsch C
Clin Exp Metastasis. 2010
PubMed ID: 20844931
Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons.
Junyent F, Alvira D, Yeste-Velasco M, de la Torre AV, Beas-Zarate C, Sureda FX, Folch J, Pallàs M, Camins A, Verdaguer E
Neurochem Int. 2010
PubMed ID: 20817061
Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.
Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK
Biochimie. 2010
PubMed ID: 20713122
Attenuation of ischemia-reperfusion injury by sevoflurane postconditioning involves protein kinase B and glycogen synthase kinase 3 beta activation in isolated rat hearts.
Fang NX, Yao YT, Shi CX, Li LH
Mol Biol Rep. 2010
PubMed ID: 20217242
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.
Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP
Science. 2010
PubMed ID: 21030605
IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.
Chapuis N, Park S, Leotoing L, Tamburini J, Verdier F, Bardet V, Green AS, Willems L, Agou F, Ifrah N, Dreyfus F, Bismuth G, Baud V, Lacombe C, Mayeux P, Bouscary D
Blood. 2010
PubMed ID: 20671123
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a.
Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE
Cancer Res. 2010
PubMed ID: 21045158
Upregulation of DLX5 promotes ovarian cancer cell proliferation by enhancing IRS-2-AKT signaling.
Tan Y, Cheung M, Pei J, Menges CW, Godwin AK, Testa JR
Cancer Res. 2010
PubMed ID: 21045156
Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.
Chang Z, Zhang Q, Feng Q, Xu J, Teng T, Luan Q, Shan C, Hu Y, Hemmings BA, Gao X, Yang Z
Dev Biol. 2010
PubMed ID: 20816796
Entamoeba histolytica cysteine proteinase 5 binds integrin on colonic cells and stimulates NFkappaB-mediated pro-inflammatory responses.
Hou Y, Mortimer L, Chadee K
J Biol Chem. 2010
PubMed ID: 20837477
AKT1 polymorphisms are associated with risk for metabolic syndrome.
Devaney JM, Gordish-Dressman H, Harmon BT, Bradbury MK, Devaney SA, Harris TB, Thompson PD, Clarkson PM, Price TB, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Seo J, Kim BH, Tosi LL, Garcia M, Li R, Zmuda JM, Delmonico MJ, Lindsay RS, Howard BV, Kraus WE, Hoffman EP
Hum Genet. 2010
PubMed ID: 21061022
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Sequential alterations in Akt, GSK3β, and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction.
Prévilon M, Pezet M, Dachez C, Mercadier JJ, Rouet-Benzineb P
Can J Physiol Pharmacol. 2010
PubMed ID: 21076497
Family-Based Analysis of Genetic Variation Underlying Psychosis-Inducing Effects of Cannabis: Sibling Analysis and Proband Follow-up.
van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Arch Gen Psychiatry. 2010
PubMed ID: 21041608
Rarity of AKT1 and AKT3 E17K mutations in squamous cell carcinoma of lung.
Do H, Salemi R, Murone C, Mitchell PL, Dobrovic A
Cell Cycle. 2010
PubMed ID: 20980808
A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.
Kunoh T, Noda T, Koseki K, Sekigawa M, Takagi M, Shin-ya K, Goshima N, Iemura S, Natsume T, Wada S, Mukai Y, Ohta S, Sasaki R, Mizukami T
Mol Cancer Ther. 2010
PubMed ID: 20978158
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells.
Kobayashi H, Butler JM, O'Donnell R, Kobayashi M, Ding BS, Bonner B, Chiu VK, Nolan DJ, Shido K, Benjamin L, Rafii S
Nat Cell Biol. 2010
PubMed ID: 20972423
cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer.
Wu HH, Wu JY, Cheng YW, Chen CY, Lee MC, Goan YG, Lee H
Clin Cancer Res. 2010
PubMed ID: 20959404
From man to mouse and back again: advances in defining tumor AKTivities in vivo.
Restuccia DF, Hemmings BA
Dis Model Mech. 2010
PubMed ID: 20940316
PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human endothelial cells.
Tsoyi K, Jang HJ, Nizamutdinova IT, Park K, Kim YM, Kim HJ, Seo HG, Lee JH, Chang KC
Atherosclerosis. 2010
PubMed ID: 20864106
Testosterone-down-regulated Akt pathway during cardiac ischemia/reperfusion: a mechanism involving BAD, Bcl-2 and FOXO3a.
Huang C, Gu H, Zhang W, Herrmann JL, Wang M
J Surg Res. 2010
PubMed ID: 20850791
Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through the phosphatidylinositol 3-kinase/Akt signaling pathway.
Zhao WD, Liu W, Fang WG, Kim KS, Chen YH
Infect Immun. 2010
PubMed ID: 20805333
A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer.
Yotsumoto F, Fukami T, Yagi H, Funakoshi A, Yoshizato T, Kuroki M, Miyamoto S
Cancer Sci. 2010
PubMed ID: 20726858
Atorvastatin upregulates nitric oxide synthases with Rho-kinase inhibition and Akt activation in the kidney of spontaneously hypertensive rats.
Ito D, Ito O, Mori N, Muroya Y, Cao PY, Takashima K, Kanazawa M, Kohzuki M
J Hypertens. 2010
PubMed ID: 20724941
Lipopolysaccharide directly stimulates aldosterone production via toll-like receptor 2 and toll-like receptor 4 related PI(3)K/Akt pathway in rat adrenal zona glomerulosa cells.
Huang HL, Chiang MF, Lin CW, Pu HF
J Cell Biochem. 2010
PubMed ID: 20665543
Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells.
van Meijl LE, Popeijus HE, Mensink RP
Mol Nutr Food Res. 2010
PubMed ID: 20512787
Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro.
Liu JJ, Liu WD, Yang HZ, Zhang Y, Fang ZG, Liu PQ, Lin DJ, Xiao RZ, Hu Y, Wang CZ, Li XD, He Y, Huang RW
Ann Hematol. 2010
PubMed ID: 20512574
Overexpression of fucosyltransferase IV promotes A431 cell proliferation through activating MAPK and PI3K/Akt signaling pathways.
Yang XS, Liu S, Liu YJ, Liu JW, Liu TJ, Wang XQ, Yan Q
J Cell Physiol. 2010
PubMed ID: 20506505
DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.
Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Côté JF, Nagasawa T, Fukui Y
Circ Res. 2010
PubMed ID: 20829512
Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.
Slattery ML, Lundgreen A, Herrick JS, Wolff RK
Mutat Res. 2010
PubMed ID: 21035469
[Activities of Akt pathway and their correlation with pathological changes in myotonic dystrophy].
Li X, Zhang W, Lv H, Wang ZX, Yuan Y
Beijing Da Xue Xue Bao. 2010
PubMed ID: 20957008
Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2.
Guha M, Fang JK, Monks R, Birnbaum MJ, Avadhani NG
Mol Biol Cell. 2010
PubMed ID: 20719961
Induction of cellular apoptosis in human breast cancer by DLBS1425, a Phaleria macrocarpa compound extract, via down-regulation of PI3-kinase/AKT pathway.
Tandrasasmita OM, Lee JS, Baek SH, Tjandrawinata RR
Cancer Biol Ther. 2010
PubMed ID: 20703095
Protein kinase B (AKT) mediates phospholipase D activation via ERK1/2 and promotes respiratory burst parameters in formylpeptide-stimulated neutrophil-like HL-60 cells.
Patel S, Djerdjouri B, Raoul-Des-Essarts Y, Dang PM, El-Benna J, Périanin A
J Biol Chem. 2010
PubMed ID: 20693286
AKT1 leader gene and downstream targets are involved in a rat model of kidney allograft tolerance.
Jovanovic V, Giacomelli L, Sivozhelezov V, Degauque N, Lair D, Soulillou JP, Pechkova E, Nicolini C, Brouard S
J Cell Biochem. 2010
PubMed ID: 20607729
Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.
Nam SY, Seo HH, Park HS, An S, Kim JY, Yang KH, Kim CS, Jeong M, Jin YW
J Biol Chem. 2010
PubMed ID: 20682768
Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.
Memarzadeh S, Zong Y, Janzen DM, Goldstein AS, Cheng D, Kurita T, Schafenacker AM, Huang J, Witte ON
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20855612
[Correlation of expression of PTEN with AKT phosphorylation level in leukemia cells].
Zhang YY, Liu T, Meng WT
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 21129241
Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls.
Nicodemus KK, Law AJ, Radulescu E, Luna A, Kolachana B, Vakkalanka R, Rujescu D, Giegling I, Straub RE, McGee K, Gold B, Dean M, Muglia P, Callicott JH, Tan HY, Weinberger DR
Arch Gen Psychiatry. 2010
PubMed ID: 20921115
Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.
Rivera M, Ricarte-Filho J, Tuttle RM, Ganly I, Shaha A, Knauf J, Fagin J, Ghossein R
Thyroid. 2010
PubMed ID: 20860430
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R
Development. 2010
PubMed ID: 20823064
Discovery of pyrrolopyrimidine inhibitors of Akt.
Blake JF, Kallan NC, Xiao D, Xu R, Bencsik JR, Skelton NJ, Spencer KL, Mitchell IS, Woessner RD, Gloor SL, Risom T, Gross SD, Martinson M, Morales TH, Vigers GP, Brandhuber BJ
Bioorg Med Chem Lett. 2010
PubMed ID: 20810279
The calreticulin-binding sequence of thrombospondin 1 regulates collagen expression and organization during tissue remodeling.
Sweetwyne MT, Pallero MA, Lu A, Van Duyn Graham L, Murphy-Ullrich JE
Am J Pathol. 2010
PubMed ID: 20724603
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.
Zhou F, Chang Z, Zhang L, Hong YK, Shen B, Wang B, Zhang F, Lu G, Tvorogov D, Alitalo K, Hemmings BA, Yang Z, He Y
Am J Pathol. 2010
PubMed ID: 20724596
Suppression of ADAM17-mediated Lyn/Akt pathways induces apoptosis of human leukemia U937 cells: Bungarus multicinctus protease inhibitor-like protein-1 uncovers the cytotoxic mechanism.
Liu WH, Chang LS
J Biol Chem. 2010
PubMed ID: 20679348
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Prenatal retinoic acid upregulates pulmonary gene expression of PI3K and AKT in nitrofen-induced pulmonary hypoplasia.
Doi T, Sugimoto K, Ruttenstock E, Dingemann J, Puri P
Pediatr Surg Int. 2010
PubMed ID: 20623292
PI3K/Akt signaling mediated apoptosis blockage and viral gene expression in oral epithelial cells during herpes simplex virus infection.
Hsu MJ, Wu CY, Chiang HH, Lai YL, Hung SL
Virus Res. 2010
PubMed ID: 20620179
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Ko FC, Chan LK, Tung EK, Lowe SW, Ng IO, Yam JW
Gastroenterology. 2010
PubMed ID: 20600027
Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway.
Zhao Y, Chen X, Cai L, Yang Y, Sui G, Fu S
J Cell Physiol. 2010
PubMed ID: 20458733
Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells.
Zheng J, Hudder A, Zukowski K, Novak RF
Cancer Lett. 2010
PubMed ID: 20417028
Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties.
Buitenhuis M, van der Linden E, Ulfman LH, Hofhuis FM, Bierings MB, Coffer PJ
Blood. 2010
PubMed ID: 20566894
Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation.
Sun X, Xie H, Yang J, Wang H, Bradshaw HB, Dey SK
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20837524
Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
Mouton V, Toussaint L, Vertommen D, Gueuning MA, Maisin L, Havaux X, Sanchez-Canedo C, Bertrand L, Dequiedt F, Hemmings BA, Hue L, Rider MH
Biochem J. 2010
PubMed ID: 20687898
PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival.
Shen X, Xi G, Radhakrishnan Y, Clemmons DR
J Biol Chem. 2010
PubMed ID: 20643654
Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair.
Lee SB, Kwon IS, Park J, Lee KH, Ahn Y, Lee C, Kim J, Choi SY, Cho SW, Ahn JY
J Biol Chem. 2010
PubMed ID: 20605787
Effects of regulator of G protein signaling 19 (RGS19) on heart development and function.
Ji YR, Kim MO, Kim SH, Yu DH, Shin MJ, Kim HJ, Yuh HS, Bae KB, Kim JY, Park HD, Lee SG, Hyun BH, Ryoo ZY
J Biol Chem. 2010
PubMed ID: 20562099
Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.
Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U
J Biol Chem. 2010
PubMed ID: 20605778
A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP
J Biol Chem. 2010
PubMed ID: 20587420
Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells.
Gan Y, Shi C, Inge L, Hibner M, Balducci J, Huang Y
Oncogene. 2010
PubMed ID: 20562913
Analysis of PI3K/AKT/mTOR signalling pathway in high risk neuroblastic tumours.
Iżycka-Świeszewska E, Drożyńska E, Rzepko R, Kobierska-Gulida G, Grajkowska W, Perek D, Balcerska A
Pol J Pathol. 2010
PubMed ID: 21290341
[Effects of PTEN over-expression on phosphatidyl inositol 3-kinase/protein kinase B signal pathway in ovarian epithelial cancer cells].
Zhai YN, Xu LL, Shen Y, Xia H, Shen YF
Zhonghua Fu Chan Ke Za Zhi. 2010
PubMed ID: 21092549
ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes improvement of locomotor function after spinal cord injury in rats.
Hu LY, Sun ZG, Wen YM, Cheng GZ, Wang SL, Zhao HB, Zhang XR
Neuroscience. 2010
PubMed ID: 20678995
Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.
Tan Y, You H, Coffey FJ, Wiest DL, Testa JR
Genesis. 2010
PubMed ID: 20665729
Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathway.
Palaniappan M, Menon KM
Mol Endocrinol. 2010
PubMed ID: 20660299
Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway.
Wang X, Ren JH, Lin F, Wei JX, Long M, Yan L, Zhang HZ
Cancer Biol Ther. 2010
PubMed ID: 20657188
BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects.
Sheikh AM, Malik M, Wen G, Chauhan A, Chauhan V, Gong CX, Liu F, Brown WT, Li X
J Neurosci Res. 2010
PubMed ID: 20648653
PI(3)king apart PTEN's role in cancer.
Zhang S, Yu D
Clin Cancer Res. 2010
PubMed ID: 20622047
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Slattery ML, Herrick JS, Lundgreen A, Fitzpatrick FA, Curtin K, Wolff RK
Carcinogenesis. 2010
PubMed ID: 20622004
Akt activation is a common event in pediatric malignant gliomas and a potential adverse prognostic marker: a report from the Children's Oncology Group.
Pollack IF, Hamilton RL, Burger PC, Brat DJ, Rosenblum MK, Murdoch GH, Nikiforova MN, Holmes EJ, Zhou T, Cohen KJ, Jakacki RI, Children's Oncology Group
J Neurooncol. 2010
PubMed ID: 20607350
Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.
Zheng Y, Peng M, Wang Z, Asara JM, Tyner AL
Mol Cell Biol. 2010
PubMed ID: 20606012
P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Huynh N, Liu KH, Baldwin GS, He H
Biochim Biophys Acta. 2010
PubMed ID: 20595063
A G(i) -independent mechanism mediating Akt phosphorylation in platelets.
Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z
J Thromb Haemost. 2010
PubMed ID: 20586915
AKT/GSK-3beta/beta-catenin signalling within hippocampus and amygdala reflects genetically determined differences in posttraumatic stress disorder like symptoms.
Dahlhoff M, Siegmund A, Golub Y, Wolf E, Holsboer F, Wotjak CT
Neuroscience. 2010
PubMed ID: 20576499
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
Hussain S, Foreman O, Perkins SL, Witzig TE, Miles RR, van Deursen J, Galardy PJ
Leukemia. 2010
PubMed ID: 20574456
Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines.
Mei C, Sun L, Liu Y, Yang Y, Cai X, Liu M, Yao W, Wang C, Li X, Wang L, Li Z, Shi Y, Qiu S, Fan J, Zha X
J Cell Biochem. 2010
PubMed ID: 20506537
Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes.
Bergandi L, Cordero M, Anselmino M, Ferraro G, Ravera L, Dalmasso P, Moiraghi C, Trevi GP, Ghigo D, Bosia A, Bergerone S
Clin Res Cardiol. 2010
PubMed ID: 20467748
Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3ß pathways.
Sun X, Zhang Y, Wang J, Wei L, Li H, Hanley G, Zhao M, Li Y, Yin D
Biochim Biophys Acta. 2010
PubMed ID: 20457218
Effect of disruption of Akt-1 of lin(-)c-kit(+) stem cells on myocardial performance in infarcted heart.
Tseng A, Stabila J, McGonnigal B, Yano N, Yang MJ, Tseng YT, Davol PA, Lum LG, Padbury JF, Zhao TC
Cardiovasc Res. 2010
PubMed ID: 20410290
Cognitive impairment following prenatal immune challenge in mice correlates with prefrontal cortical AKT1 deficiency.
Bitanihirwe BK, Weber L, Feldon J, Meyer U
Int J Neuropsychopharmacol. 2010
PubMed ID: 20219156
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.
Xiao L, Gong LL, Yuan D, Deng M, Zeng XM, Chen LL, Zhang L, Yan Q, Liu JP, Hu XH, Sun SM, Liu J, Ma HL, Zheng CB, Fu H, Chen PC, Zhao JQ, Xie SS, Zou LJ, Xiao YM, Liu WB, Zhang J, Liu Y, Li DW
Cell Death Differ. 2010
PubMed ID: 20186153
DHEA prevents Abeta(25-35)-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling.
Li L, Xu B, Zhu Y, Chen L, Sokabe M, Chen L
Neuropharmacology. 2010
PubMed ID: 20167228
High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K.
Treekitkarnmongkol W, Suthiphongchai T
World J Gastroenterol. 2010
PubMed ID: 20731018
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ
Dev Cell. 2010
PubMed ID: 20708588
7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathways.
Liao PL, Cheng YW, Li CH, Wang YT, Kang JJ
Toxicol Lett. 2010
PubMed ID: 20466046
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B
Mol Cell. 2010
PubMed ID: 20705244
Transcriptional activation of peroxisome proliferator-activated receptor-gamma requires activation of both protein kinase A and Akt during adipocyte differentiation.
Kim SP, Ha JM, Yun SJ, Kim EK, Chung SW, Hong KW, Kim CD, Bae SS
Biochem Biophys Res Commun. 2010
PubMed ID: 20638365
Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation.
Wang P, Zhu F, Lee NH, Konstantopoulos K
J Biol Chem. 2010
PubMed ID: 20516073
[Expressions of phospho-Erk1/2 and phospho-Akt1 in the corpus cavernosum of aged rats].
Mao JB, Xu CX, Jiang R
Zhonghua Nan Ke Xue. 2010
PubMed ID: 21090343
Beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase.
Cianfrocca R, Rosanò L, Spinella F, Di Castro V, Natali PG, Bagnato A
Can J Physiol Pharmacol. 2010
PubMed ID: 20725137
[Celastrol down-regulates expression of P-Akt and cyclin D1 in HL-60 cells and induces apoptosis].
Ma YL, Yi H, Yang FL, Zhang Y, Wang Y, Wang Y
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 20723296
Heat shock protein 90 protects rat mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis via the PI3K/Akt and ERK1/2 pathways.
Gao F, Hu XY, Xie XJ, Xu QY, Wang YP, Liu XB, Xiang MX, Sun Y, Wang JA
J Zhejiang Univ Sci B. 2010
PubMed ID: 20669351
miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells.
Lin RJ, Lin YC, Yu AL
Mol Carcinog. 2010
PubMed ID: 20623644
Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations.
Hafner C, Landthaler M, Vogt T
Exp Dermatol. 2010
PubMed ID: 20557351
IGF-I activation of the AKT pathway is impaired in visceral but not subcutaneous preadipocytes from obese subjects.
Cleveland-Donovan K, Maile LA, Tsiaras WG, Tchkonia T, Kirkland JL, Boney CM
Endocrinology. 2010
PubMed ID: 20555032
Expression analysis of Akt and MAPK signaling pathways in lung tissue of patients with idiopathic pulmonary fibrosis (IPF).
Antoniou KM, Margaritopoulos GA, Soufla G, Symvoulakis E, Vassalou E, Lymbouridou R, Samara KD, Kappou D, Spandidos DA, Siafakas NM
J Recept Signal Transduct Res. 2010
PubMed ID: 20536315
Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells.
Wang YK, Zhu YL, Qiu FM, Zhang T, Chen ZG, Zheng S, Huang J
Carcinogenesis. 2010
PubMed ID: 20530554
Nifedipine inhibits vascular smooth muscle cell dedifferentiation via downregulation of Akt signaling.
Kaimoto T, Yasuda O, Ohishi M, Mogi M, Takemura Y, Suhara T, Ogihara T, Fukuo K, Rakugi H
Hypertension. 2010
PubMed ID: 20530298
Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients.
Chen M, Gu J, Delclos GL, Killary AM, Fan Z, Hildebrandt MA, Chamberlain RM, Grossman HB, Dinney CP, Wu X
Carcinogenesis. 2010
PubMed ID: 20530239
Activation of Akt/FoxO signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats.
Zhan L, Wang T, Li W, Xu ZC, Sun W, Xu E
J Neurochem. 2010
PubMed ID: 20492357
Shepherding AKT and androgen receptor by Ack1 tyrosine kinase.
Mahajan K, Mahajan NP
J Cell Physiol. 2010
PubMed ID: 20432460
Upregulation of CXCR4 favoring neural-like cells migration via AKT activation.
Li S, Deng L, Gong L, Bian H, Dai Y, Wang Y
Neurosci Res. 2010
PubMed ID: 20412823
Neurotrophin-4 (ntf4) mediates neurogenesis in mouse embryonic neural stem cells through the inhibition of the signal transducer and activator of transcription-3 (stat3) and the modulation of the activity of protein kinase B.
Shen Y, Inoue N, Heese K
Cell Mol Neurobiol. 2010
PubMed ID: 20407817
AKT loss in human epithelial cells treated with severe hypoxia.
Box AH, Kim SM, Demetrick DJ
Biochim Biophys Acta. 2010
PubMed ID: 20347887
EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes.
Tung WH, Lee IT, Hsieh HL, Yang CM
J Cell Physiol. 2010
PubMed ID: 20333648
Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament.
Kippenberger S, Hofmann M, Zöller N, Thaçi D, Müller J, Kaufmann R, Bernd A
Biochim Biophys Acta. 2010
PubMed ID: 20307589
Clinical significance of pAKT and CD44v6 overexpression with breast cancer.
Yu P, Zhou L, Ke W, Li K
J Cancer Res Clin Oncol. 2010
PubMed ID: 20157733
Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids.
Liao WT, Yu HS, Arbiser JL, Hong CH, Govindarajan B, Chai CY, Shan WJ, Lin YF, Chen GS, Lee CH
Exp Dermatol. 2010
PubMed ID: 20100200
IQGAP1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation by Akt activation.
Chen F, Zhu HH, Zhou LF, Wu SS, Wang J, Chen Z
Exp Mol Med. 2010
PubMed ID: 20530982
Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence.
Bousman CA, Glatt SJ, Cherner M, Atkinson JH, Grant I, Tsuang MT, Everall IP, HNRC Group
Psychiatry Res. 2010
PubMed ID: 20478633
Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4.
Li P, Jayarama S, Ganesh L, Mordi D, Carr R, Kanteti P, Hay N, Prabhakar BS
J Biol Chem. 2010
PubMed ID: 20484047
The interferon-gamma-induced murine guanylate-binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet-derived growth factor treatment: role for phosphatidylinositol 3-kinase.
Messmer-Blust AF, Balasubramanian S, Gorbacheva VY, Jeyaratnam JA, Vestal DJ
Mol Biol Cell. 2010
PubMed ID: 20505078
Cdo interacts with APPL1 and activates Akt in myoblast differentiation.
Bae GU, Lee JR, Kim BG, Han JW, Leem YE, Lee HJ, Ho SM, Hahn MJ, Kang JS
Mol Biol Cell. 2010
PubMed ID: 20484574
Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastoma.
Archer CR, Koomoa DL, Mitsunaga EM, Clerc J, Shimizu M, Kaiser M, Schellenberg B, Dudler R, Bachmann AS
Biochem Pharmacol. 2010
PubMed ID: 20362557
Suppression of Akt1 phosphorylation by adenoviral transfer of the PTEN gene inhibits hypoxia-induced proliferation of rat pulmonary arterial smooth muscle cells.
Luo C, Yi B, Bai L, Xia Y, Wang G, Qian G, Feng H
Biochem Biophys Res Commun. 2010
PubMed ID: 20515660
Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle.
Baba T, Kobayashi H, Kawasaki H, Mineki R, Naito H, Ohmori D
FEBS Lett. 2010
PubMed ID: 20488185
Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer.
Liu J, Cheng Sun SH, Sun SJ, Huang C, Hu HH, Jin YB, Qiu ZJ
Ann Acad Med Singapore. 2010
PubMed ID: 20697673
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.
Eke I, Koch U, Hehlgans S, Sandfort V, Stanchi F, Zips D, Baumann M, Shevchenko A, Pilarsky C, Haase M, Baretton GB, Calleja V, Larijani B, Fässler R, Cordes N
J Clin Invest. 2010
PubMed ID: 20530873
Akt associates with nuclear factor kappaB and plays an important role in chemoresistance of gastric cancer cells.
Yu LL, Dai N, Yu HG, Sun LM, Si JM
Oncol Rep. 2010
PubMed ID: 20514451
Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway.
Wen YG, Wang Q, Zhou CZ, Qiu GQ, Peng ZH, Tang HM
Oncol Rep. 2010
PubMed ID: 20514448
Murine folliculogenesis in vitro is stage-specifically regulated by insulin via the Akt signaling pathway.
Zhang P, Chao H, Sun X, Li L, Shi Q, Shen W
Histochem Cell Biol. 2010
PubMed ID: 20495820
Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.
Mailankot M, Howell S, Nagaraj RH
Biochim Biophys Acta. 2010
PubMed ID: 20478381
An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration.
Ramachandran A, Ranpura SA, Gong EM, Mulone M, Cannon GM, Adam RM
Am J Pathol. 2010
PubMed ID: 20472895
PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.
Feng Q, Di R, Tao F, Chang Z, Lu S, Fan W, Shan C, Li X, Yang Z
Mol Cell Biol. 2010
PubMed ID: 20457809
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells.
Guo G, Qiu X, Wang S, Chen Y, Rothman PB, Wang Z, Chen Y, Wang G, Chen JL
Oncogene. 2010
PubMed ID: 20440266
Neuregulin 1-induced AKT phosphorylation in monozygotic twins discordant for schizophrenia.
Seres I, Kelemen O, Benedek G, Kéri S
Neurochem Int. 2010
PubMed ID: 20371257
Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.
Lee HJ, So JY, DeCastro A, Smolarek A, Paul S, Maehr H, Uskokovic M, Suh N
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20304052
Maggot excretions/secretions induces human microvascular endothelial cell migration through AKT1.
Wang SY, Wang K, Xin Y, Lv DC
Mol Biol Rep. 2010
PubMed ID: 19757167
Design of selective, ATP-competitive inhibitors of Akt.
Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, Briere D, Clark T, Corbett M, Jakubczak J, Kakar S, Knauth E, Lippa B, Luzzio MJ, Mansour M, Martinelli G, Marx M, Nelson K, Pandit J, Rajamohan F, Robinson S, Subramanyam C, Wei L, Wythes M, Morris J
J Med Chem. 2010
PubMed ID: 20481595
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
Mund T, Pelham HR
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534535
Ovarian cancer ascites protects from TRAIL-induced cell death through alphavbeta5 integrin-mediated focal adhesion kinase and Akt activation.
Lane D, Goncharenko-Khaider N, Rancourt C, Piché A
Oncogene. 2010
PubMed ID: 20400979
PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage.
Vichalkovski A, Gresko E, Hess D, Restuccia DF, Hemmings BA
Oncogene. 2010
PubMed ID: 20400976
CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis.
Fritz RD, Varga Z, Radziwill G
Oncogene. 2010
PubMed ID: 20383191
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK
Cancer Cell. 2010
PubMed ID: 20541701
Bam32/DAPP1 promotes B cell adhesion and formation of polarized conjugates with T cells.
Al-Alwan M, Hou S, Zhang TT, Makondo K, Marshall AJ
J Immunol. 2010
PubMed ID: 20495066
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.
van de Laar L, Buitenhuis M, Wensveen FM, Janssen HL, Coffer PJ, Woltman AM
J Immunol. 2010
PubMed ID: 20488790
Selective blockade of protein kinase B protects the rat and human myocardium against ischaemic injury.
Linares-Palomino J, Husainy MA, Lai VK, Dickenson JM, Galiñanes M
J Physiol. 2010
PubMed ID: 20403980
Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
Carraway MS, Suliman HB, Jones WS, Chen CW, Babiker A, Piantadosi CA
Circ Res. 2010
PubMed ID: 20395592
Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.
Krawczyk CM, Holowka T, Sun J, Blagih J, Amiel E, DeBerardinis RJ, Cross JR, Jung E, Thompson CB, Jones RG, Pearce EJ
Blood. 2010
PubMed ID: 20351312
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA, Ghossein RA
Mod Pathol. 2010
PubMed ID: 20526288
Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).
Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, Wong KW, Herman IM, Isberg RR, Buchsbaum RJ
J Biol Chem. 2010
PubMed ID: 20360004
[Significance and expression of FKHR and AKT after subarachnoid hemorrhage in rat brain cortex].
Miao CM, Luo Q, Wang WW, Kang JS, Shi GY, Li HY, Zhang Y
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20973227
HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications.
Izquierdo L, Truan D, Mengual L, Mallofré C, Alcaraz A
Anticancer Res. 2010
PubMed ID: 20651405
[Effects of exercise on expression and phosphorylation of PI3K and PKB in insulin signaling in the skeletal muscles of type 2 diabetic rats].
Cao SC, Zhao G, Chang B, Zhang H
Nan Fang Yi Ke Da Xue Xue Bao. 2010
PubMed ID: 20584641
Activated PI3K/Akt/COX-2 pathway induces resistance to radiation in human cervical cancer HeLa cells.
Xia S, Zhao Y, Yu S, Zhang M
Cancer Biother Radiopharm. 2010
PubMed ID: 20578837
Programmed cell death 4 (PDCD4) enhances the sensitivity of gastric cancer cells to TRAIL-induced apoptosis by inhibiting the PI3K/Akt signaling pathway.
Wang WQ, Zhang H, Wang HB, Sun YG, Peng ZH, Zhou G, Yang SM, Wang RQ, Fang DC
Mol Diagn Ther. 2010
PubMed ID: 20560677
Genetic association of the AKT1 gene with schizophrenia in a British population.
Mathur A, Law MH, Megson IL, Shaw DJ, Wei J
Psychiatr Genet. 2010
PubMed ID: 20421846
Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia.
Koga M, Ishiguro H, Horiuchi Y, Inada T, Ujike H, Itokawa M, Otowa T, Watanabe Y, Someya T, Arinami T
Psychiatr Genet. 2010
PubMed ID: 20414143
The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin.
Metalli D, Lovat F, Tripodi F, Genua M, Xu SQ, Spinelli M, Alberghina L, Vanoni M, Baffa R, Gomella LG, Iozzo RV, Morrione A
Am J Pathol. 2010
PubMed ID: 20395438
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.
Creamer BA, Sakamoto K, Schmidt JW, Triplett AA, Moriggl R, Wagner KU
Mol Cell Biol. 2010
PubMed ID: 20385773
Therapeutic hypothermia cardioprotection via Akt- and nitric oxide-mediated attenuation of mitochondrial oxidants.
Shao ZH, Sharp WW, Wojcik KR, Li CQ, Han M, Chang WT, Ramachandran S, Li J, Hamann KJ, Vanden Hoek TL
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20382860
MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function.
Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20378849
Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest.
Beiser DG, Wojcik KR, Zhao D, Orbelyan GA, Hamann KJ, Vanden Hoek TL
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20363892
COMMD1 downregulates the epithelial sodium channel through Nedd4-2.
Ke Y, Butt AG, Swart M, Liu YF, McDonald FJ
Am J Physiol Renal Physiol. 2010
PubMed ID: 20237237
Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts.
Tseng WP, Yang SN, Lai CH, Tang CH
J Cell Physiol. 2010
PubMed ID: 20232298
Mutational and immunohistochemical study of the PI3K/Akt pathway in papillary thyroid carcinoma in Greece.
Sozopoulos E, Litsiou H, Voutsinas G, Mitsiades N, Anagnostakis N, Tseva T, Patsouris E, Tseleni-Balafouta S
Endocr Pathol. 2010
PubMed ID: 20186503
Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.
Guha M, Tang W, Sondheimer N, Avadhani NG
Biochim Biophys Acta. 2010
PubMed ID: 20153290
Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients.
Magno LA, Miranda DM, Neves FS, Pimenta GJ, Mello MP, De Marco LA, Correa H, Romano-Silva MA
Genes Brain Behav. 2010
PubMed ID: 20132317
Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma.
Ismail SI, Mahmoud IS, Msallam MM, Sughayer MA
Leuk Res. 2010
PubMed ID: 20022634
Glutamate promotes cell growth by EGFR signaling on U-87MG human glioblastoma cell line.
Schunemann DP, Grivicich I, Regner A, Leal LF, de Araújo DR, Jotz GP, Fedrigo CA, Simon D, da Rocha AB
Pathol Oncol Res. 2010
PubMed ID: 19997873
Immunohistochemical detection of phospho-Akt, phospho-BAD, HER2 and oestrogen receptors alpha and beta in Malaysian breast cancer patients.
Seow HF, Yip WK, Loh HW, Ithnin H, Por P, Rohaizak M
Pathol Oncol Res. 2010
PubMed ID: 19882362
Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes.
Nandy D, Asmann YW, Mukhopadhyay D, Basu A
J Cell Mol Med. 2010
PubMed ID: 19754670
Hepatocyte growth factor protects endothelial progenitor cell from damage of low-density lipoprotein cholesterol via the PI3K/Akt signaling pathway.
Yu X, Song M, Chen J, Zhu G, Zhao G, Wang H, Hunag L
Mol Biol Rep. 2010
PubMed ID: 19685158
The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis.
Barré B, Perkins ND
Mol Cell. 2010
PubMed ID: 20513428
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.
Saji M, Ringel MD
Mol Cell Endocrinol. 2010
PubMed ID: 19897009
Akt isoforms differentially regulate neutrophil functions.
Chen J, Tang H, Hay N, Xu J, Ye RD
Blood. 2010
PubMed ID: 20332370
Inhibition of CtBP1 activity by Akt-mediated phosphorylation.
Merrill JC, Kagey MH, Melhuish TA, Powers SE, Zerlanko BJ, Wotton D
J Mol Biol. 2010
PubMed ID: 20361981
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.
Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA
Blood. 2010
PubMed ID: 20354168
Akt1 and Akt2 promote peripheral B-cell maturation and survival.
Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D
Blood. 2010
PubMed ID: 20042722
Absence of activating somatic mutations of PI3KCA and AKT1 genes in South Indian women with endometriosis.
Rai P, Deenadayal M, Shivaji S
Eur J Obstet Gynecol Reprod Biol. 2010
PubMed ID: 20493625
Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells.
Habib GM
J Cell Biochem. 2010
PubMed ID: 20336670
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration.
Chin YR, Toker A
Mol Cell. 2010
PubMed ID: 20471940
E17K substitution in AKT1 in prostate cancer.
Boormans JL, Korsten H, Ziel-van der Made AC, van Leenders GJ, Verhagen PC, Trapman J
Br J Cancer. 2010
PubMed ID: 20407443
Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G, Damon C, Mouzat K, Caira F, Baron S, Lobaccaro JM
Oncogene. 2010
PubMed ID: 20190811
PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy.
Pu X, Hildebrandt MA, Lu C, Lin J, Stewart DJ, Ye Y, Gu J, Spitz MR, Wu X
Lung Cancer. 2010
PubMed ID: 20447721
The clinicopathological and prognostic relevance of pyruvate kinase M2 and pAkt expression in breast cancer.
Benesch C, Schneider C, Voelker HU, Kapp M, Caffier H, Krockenberger M, Dietl J, Kammerer U, Schmidt M
Anticancer Res. 2010
PubMed ID: 20592362
Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis.
Suzuki E, Daniels TR, Helguera G, Penichet ML, Umezawa K, Bonavida B
Int J Oncol. 2010
PubMed ID: 20372806
Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation.
Grotegut S, Kappler R, Tarimoradi S, Lehembre F, Christofori G, Von Schweinitz D
Int J Oncol. 2010
PubMed ID: 20372801
Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.
Edouard T, Combier JP, Nédélec A, Bel-Vialar S, Métrich M, Conte-Auriol F, Lyonnet S, Parfait B, Tauber M, Salles JP, Lezoualc'h F, Yart A, Raynal P
Mol Cell Biol. 2010
PubMed ID: 20308328
IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression.
Yoshida T, Semprun-Prieto L, Sukhanov S, Delafontaine P
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20228261
Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications.
Badve S, Collins NR, Bhat-Nakshatri P, Turbin D, Leung S, Thorat M, Dunn SE, Geistlinger TR, Carroll JS, Brown M, Bose S, Teitell MA, Nakshatri H
Am J Pathol. 2010
PubMed ID: 20228224
F104S c-Mpl responds to a transmembrane domain-binding thrombopoietin receptor agonist: proof of concept that selected receptor mutations in congenital amegakaryocytic thrombocytopenia can be stimulated with alternative thrombopoietic agents.
Fox NE, Lim J, Chen R, Geddis AE
Exp Hematol. 2010
PubMed ID: 20188141
The role of brain-derived neurotrophic factor in mouse oocyte maturation in vitro involves activation of protein kinase B.
Zhang L, Liang Y, Liu Y, Xiong CL
Theriogenology. 2010
PubMed ID: 20171721
Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion.
Sharma NR, Mani P, Nandwani N, Mishra R, Rana A, Sarkar DP
J Virol. 2010
PubMed ID: 20164223
TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.
Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J
J Biol Chem. 2010
PubMed ID: 20194497
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations.
Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins MJ, Gorkin D, Reis M, Vogelstein B, Polyak K, Cowherd M, Buckhaults PJ, Park BH
Oncogene. 2010
PubMed ID: 20101210
FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.
Chen CC, Jeon SM, Bhaskar PT, Nogueira V, Sundararajan D, Tonic I, Park Y, Hay N
Dev Cell. 2010
PubMed ID: 20412774
Fas apoptosis inhibitory molecule regulates T cell receptor-mediated apoptosis of thymocytes by modulating Akt activation and Nur77 expression.
Huo J, Xu S, Lam KP
J Biol Chem. 2010
PubMed ID: 20178987
Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells.
He X, Ota T, Liu P, Su C, Chien J, Shridhar V
Cancer Res. 2010
PubMed ID: 20388781
Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA
J Cell Sci. 2010
PubMed ID: 20332111
Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival.
Perumalsamy LR, Nagala M, Sarin A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20339081
Mouse models for breast cancer metastasis.
Kim IS, Baek SH
Biochem Biophys Res Commun. 2010
PubMed ID: 20230796
Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.
Han W, Ming M, He TC, He YY
J Biol Chem. 2010
PubMed ID: 20154081
High level of apoptosis and low AKT activation in mass screening as opposed to standard neuroblastoma.
Sartelet H, Ohta S, Barrette S, Rougemont AL, Brevet M, Regairaz M, Harvey I, Bernard C, Fabre M, Gaboury L, Oligny LL, Bosq J, Valteau-Couanet D, Vassal G
Histopathology. 2010
PubMed ID: 20459571
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.
Ramana KV, Tammali R, Srivastava SK
Mol Cancer Ther. 2010
PubMed ID: 20354121
Involvement of Akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer H446 cell apoptosis.
Wang L, Liu XK, Shi XQ
Chin J Cancer. 2010
PubMed ID: 20346214
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.
Ren B, Deng Y, Mukhopadhyay A, Lanahan AA, Zhuang ZW, Moodie KL, Mulligan-Kehoe MJ, Byzova TV, Peterson RT, Simons M
J Clin Invest. 2010
PubMed ID: 20237411
Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development.
Pan Y, Carbe C, Powers A, Feng GS, Zhang X
Development. 2010
PubMed ID: 20215346
Akt inhibition up-regulates MMP1 through a CCN2-dependent pathway in human dermal fibroblasts.
Bujor AM, Nakerakanti S, Morris E, Hant FN, Trojanowska M
Exp Dermatol. 2010
PubMed ID: 20201953
PTEN/pAkt/p53 signaling pathway correlates with the radioresponse of non-small cell lung cancer.
Jung IL, Kang HJ, Kim KC, Kim IG
Int J Mol Med. 2010
PubMed ID: 20198299
Evaluation of the mTOR pathway in ocular (uvea and conjunctiva) melanoma.
Pópulo H, Soares P, Rocha AS, Silva P, Lopes JM
Melanoma Res. 2010
PubMed ID: 20173664
Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia.
Carloni S, Girelli S, Scopa C, Buonocore G, Longini M, Balduini W
Autophagy. 2010
PubMed ID: 20168088
AKT1 polymorphisms are associated with tuberculosis in the Chinese population.
Wang X, Cao Z, Jiang J, Zhu Y, Dong M, Tong A, Cheng X
Int J Immunogenet. 2010
PubMed ID: 20141546
Overexpression of Par-4 sensitizes TRAIL-induced apoptosis via inactivation of NF-kappaB and Akt signaling pathways in renal cancer cells.
Lee TJ, Jang JH, Noh HJ, Park EJ, Choi KS, Kwon TK
J Cell Biochem. 2010
PubMed ID: 20127709
Prostaglandin E2 induces CYP1B1 expression via ligand-independent activation of the ERalpha pathway in human breast cancer cells.
Han EH, Kim HG, Hwang YP, Song GY, Jeong HG
Toxicol Sci. 2010
PubMed ID: 20093341
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex.
Bjørgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K
Mol Cell Biol. 2010
PubMed ID: 20086095
Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: effect on myotube fusion.
Roffe S, Hagai Y, Pines M, Halevy O
Exp Cell Res. 2010
PubMed ID: 20060825
Inhibition of Akt signaling by exclusion from lipid rafts in normal and transformed epidermal keratinocytes.
Calay D, Vind-Kezunovic D, Frankart A, Lambert S, Poumay Y, Gniadecki R
J Invest Dermatol. 2010
PubMed ID: 20054340
Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3.
Larance M, Rowland AF, Hoehn KL, Humphreys DT, Preiss T, Guilhaus M, James DE
Mol Cell Proteomics. 2010
PubMed ID: 20051463
Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt.
Deng J, Han Y, Yan C, Tian X, Tao J, Kang J, Li S
Apoptosis. 2010
PubMed ID: 19997978
Purification and characterization of recombinant CH3 domain fragment of the CREB-binding protein.
Drendall CI, Pham QH, Dietze EC
Protein Expr Purif. 2010
PubMed ID: 19995607
The time course of Akt and ERK activation on XIAP expression in HEK 293 cell line.
Abkhezr M, Keramati AR, Ostad SN, Davoodi J, Ghahremani MH
Mol Biol Rep. 2010
PubMed ID: 19649722
Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production.
Lu Y, Azad N, Wang L, Iyer AK, Castranova V, Jiang BH, Rojanasakul Y
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19520917
Hierarchical clustering of immunohistochemical analysis of the activated ErbB/PI3K/Akt/NF-kappaB signalling pathway and prognostic significance in prostate cancer.
Koumakpayi IH, Le Page C, Mes-Masson AM, Saad F
Br J Cancer. 2010
PubMed ID: 20216540
Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival.
May V, Lutz E, MacKenzie C, Schutz KC, Dozark K, Braas KM
J Biol Chem. 2010
PubMed ID: 20093365
CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling.
Trazzi S, Steger M, Mitrugno VM, Bartesaghi R, Ciani E
J Biol Chem. 2010
PubMed ID: 20083607
Akt Cys-310-targeted inhibition by hydroxylated benzene derivatives is tightly linked to their immunosuppressive effects.
Lee JY, Lee YG, Lee J, Yang KJ, Kim AR, Kim JY, Won MH, Park J, Yoo BC, Kim S, Cho WJ, Cho JY
J Biol Chem. 2010
PubMed ID: 20054000
Receptor interacting protein 3 suppresses vascular smooth muscle cell growth by inhibition of the phosphoinositide 3-kinase-Akt axis.
Li Q, Li G, Lan X, Zheng M, Chen KH, Cao CM, Xiao RP
J Biol Chem. 2010
PubMed ID: 20042608
Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling.
Mascanfroni ID, Montesinos Mdel M, Alamino VA, Susperreguy S, Nicola JP, Ilarregui JM, Masini-Repiso AM, Rabinovich GA, Pellizas CG
J Biol Chem. 2010
PubMed ID: 20018842
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.
Yarden RI, Friedman E, Metsuyanim S, Olender T, Ben-Asher E, Papa MZ
Mol Carcinog. 2010
PubMed ID: 20306497
Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS
J Biol Chem. 2010
PubMed ID: 20042609
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis.
Qiu W, Leibowitz B, Zhang L, Yu J
Oncogene. 2010
PubMed ID: 19966853
Allele-specific tumor spectrum in pten knockin mice.
Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, Rosol TJ, Eng C, Ostrowski MC, Leone G
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20194734
ATX expression and LPA signalling are vital for the development of the nervous system.
Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V
Dev Biol. 2010
PubMed ID: 20079728
Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in vivo.
Zittermann SI, Capurro MI, Shi W, Filmus J
Int J Cancer. 2010
PubMed ID: 19816934
Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways.
Björklund MA, Vaahtomeri K, Peltonen K, Viollet B, Mäkelä TP, Band AM, Laiho M
Exp Cell Res. 2010
PubMed ID: 20036235
Akt isoforms regulate intermediate filament protein levels in epithelial carcinoma cells.
Fortier AM, Van Themsche C, Asselin E, Cadrin M
FEBS Lett. 2010
PubMed ID: 20109457
Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition.
Fan Y, Dickman KG, Zong WX
J Biol Chem. 2010
PubMed ID: 20018866
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
Phosphorylation of phosphatidylinositol-3-kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection during hypoxia.
Milano G, von Segesser LK, Morel S, Joncic A, Bianciardi P, Vassalli G, Samaja M
Exp Biol Med (Maywood). 2010
PubMed ID: 20404059
Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
Kimura M, Murakami T, Kizaka-Kondoh S, Itoh M, Yamamoto K, Hojo Y, Takano M, Kario K, Shimada K, Kobayashi E
J Cell Sci. 2010
PubMed ID: 20164304
Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
Giovannetti E, Zucali PA, Peters GJ, Cortesi F, D'Incecco A, Smit EF, Falcone A, Burgers JA, Santoro A, Danesi R, Giaccone G, Tibaldi C
Mol Cancer Ther. 2010
PubMed ID: 20159991
Adhesion of ST6Gal I-mediated human colon cancer cells to fibronectin contributes to cell survival by integrin beta1-mediated paxillin and AKT activation.
Lee M, Park JJ, Lee YS
Oncol Rep. 2010
PubMed ID: 20127017
Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells.
Zhou X, Ren Y, Han L, Mei M, Xu P, Zhang CZ, Wang GX, Jia ZF, Pu PY, Kang CS
Int J Oncol. 2010
PubMed ID: 20126987
Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R
Mol Biol Cell. 2010
PubMed ID: 20110348
Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.
Goh FG, Piccinini AM, Krausgruber T, Udalova IA, Midwood KS
J Immunol. 2010
PubMed ID: 20107185
Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population.
Zhang K, Yang C, Xu Y, Sun N, Yang H, Liu J, Xu Q, Shen Y
J Neural Transm. 2010
PubMed ID: 20033742
Akt-1 mediates survival of chondrocytes from endoplasmic reticulum-induced stress.
Price J, Zaidi AK, Bohensky J, Srinivas V, Shapiro IM, Ali H
J Cell Physiol. 2010
PubMed ID: 20020442
The Akt isoforms are present at distinct subcellular locations.
Santi SA, Lee H
Am J Physiol Cell Physiol. 2010
PubMed ID: 20018949
Heat shock cognate protein 70 is essential for Akt signaling in endothelial function.
Shiota M, Kusakabe H, Izumi Y, Hikita Y, Nakao T, Funae Y, Miura K, Iwao H
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20018937
Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma.
Uddin S, Bavi P, Siraj AK, Ahmed M, Al-Rasheed M, Hussain AR, Ahmed M, Amin T, Alzahrani A, Al-Dayel F, Abubaker J, Bu R, Al-Kuraya KS
Endocr Relat Cancer. 2010
PubMed ID: 20008098
PTH inactivates the AKT survival pathway in the colonic cell line Caco-2.
Calvo N, de Boland AR, Gentili C
Biochim Biophys Acta. 2010
PubMed ID: 20005908
Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis.
Chen W, Bai L, Wang X, Xu S, Belinsky SA, Lin Y
Mol Pharmacol. 2010
PubMed ID: 19933775
No association between AKT1 polymorphism and schizophrenia: a case-control study in a Korean population and a meta-analysis.
Lee KY, Joo EJ, Jeong SH, Kang UG, Roh MS, Kim SH, Song JY, Hwang JY, Kim SG, Lee N, Ahn YM, Kim YS
Neurosci Res. 2010
PubMed ID: 19931325
P53 and p38 MAPK pathways are involved in MONCPT-induced cell cycle G2/M arrest in human non-small cell lung cancer A549.
Zhang C, Zhu H, Yang X, Lou J, Zhu D, Lu W, He Q, Yang B
J Cancer Res Clin Oncol. 2010
PubMed ID: 19727814
In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells.
Ozbay T, Durden DL, Liu T, O'Regan RM, Nahta R
Cancer Chemother Pharmacol. 2010
PubMed ID: 19636556
Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines.
Wallerand H, Cai Y, Wainberg ZA, Garraway I, Lascombe I, Nicolle G, Thiery JP, Bittard H, Radvanyi F, Reiter RR
Urol Oncol. 2010
PubMed ID: 19070520
Association of AKT1 gene variants and protein expression in both schizophrenia and bipolar disorder.
Karege F, Perroud N, Schürhoff F, Méary A, Marillier G, Burkhardt S, Ballmann E, Fernandez R, Jamain S, Leboyer M, La Harpe R, Malafosse A
Genes Brain Behav. 2010
PubMed ID: 20214684
Inhibition of protein kinase Akt1 by apoptosis signal-regulating kinase-1 (ASK1) is involved in apoptotic inhibition of regulatory volume increase.
Subramanyam M, Takahashi N, Hasegawa Y, Mohri T, Okada Y
J Biol Chem. 2010
PubMed ID: 20048146
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts.
Tan Y, You H, Wu C, Altomare DA, Testa JR
J Biol Chem. 2010
PubMed ID: 20040596
Overcoming amino-Nogo-induced inhibition of cell spreading and neurite outgrowth by 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.
Deng K, Gao Y, Cao Z, Graziani EI, Wood A, Doherty P, Walsh FS
J Biol Chem. 2010
PubMed ID: 20018888
[Akt involved in diazoxide preconditioning against rat hippocampal neuronal apoptosis induced by anoxia-reoxygenation injury].
Liu RG, Song N, Li JM, Cui X, Chen YQ
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20368077
Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.
Kim K, Kim KH, Kim HY, Cho HK, Sakamoto N, Cheong J
FEBS Lett. 2010
PubMed ID: 20026048
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
Whelan SA, Dias WB, Thiruneelakantapillai L, Lane MD, Hart GW
J Biol Chem. 2010
PubMed ID: 20018868
Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock.
Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, Garvey ME, Frangogiannis NG, Michael LH, Chow CW, Dyck JR, Young ME
Circ Res. 2010
PubMed ID: 20007913
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.
Kharas MG, Okabe R, Ganis JJ, Gozo M, Khandan T, Paktinat M, Gilliland DG, Gritsman K
Blood. 2010
PubMed ID: 20008787
Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells.
Omerovic J, Clague MJ, Prior IA
Biochem J. 2010
PubMed ID: 19922411
Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation.
Ericson K, Gan C, Cheong I, Rago C, Samuels Y, Velculescu VE, Kinzler KW, Huso DL, Vogelstein B, Papadopoulos N
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133737
Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis.
Chung CW, Zhang QL, Qiao LY
J Biol Chem. 2010
PubMed ID: 19996110
Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120.
Yuan Z, Kim D, Shu S, Wu J, Guo J, Xiao L, Kaneko S, Coppola D, Cheng JQ
J Biol Chem. 2010
PubMed ID: 19940129
The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medullary thyroid carcinoma cells.
Grozinsky-Glasberg S, Rubinfeld H, Nordenberg Y, Gorshtein A, Praiss M, Kendler E, Feinmesser R, Grossman AB, Shimon I
Mol Cell Endocrinol. 2010
PubMed ID: 19815051
Rituximab inhibits B-cell receptor signaling.
Kheirallah S, Caron P, Gross E, Quillet-Mary A, Bertrand-Michel J, Fournié JJ, Laurent G, Bezombes C
Blood. 2010
PubMed ID: 19965664
[Expressions of Erk1/2 and PKB/Akt in the corpus cavernosum of castrated rats]
Xu CX, Mao JB, Jiang R
Zhonghua Nan Ke Xue. 2010
PubMed ID: 20369692
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
Feng Z
Cold Spring Harb Perspect Biol. 2010
PubMed ID: 20182617
Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation.
Sinn B, Tallen G, Schroeder G, Grassl B, Schulze J, Budach V, Tinhofer I
Mol Cancer Ther. 2010
PubMed ID: 20103602
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, Kolch W
Cancer Res. 2010
PubMed ID: 20086174
Regulation of Akt signaling activation by ubiquitination.
Yang WL, Wu CY, Wu J, Lin HK
Cell Cycle. 2010
PubMed ID: 20081374
15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway.
Wang S, Wang Y, Jiang J, Wang R, Li L, Qiu Z, Wu H, Zhu D
Prostaglandins Other Lipid Mediat. 2010
PubMed ID: 20060487
Regulation of the Ca(2+) channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve.
Sopjani M, Kunert A, Czarkowski K, Klaus F, Laufer J, Föller M, Lang F
J Membr Biol. 2010
PubMed ID: 20041238
Inhibitory effect of baicalein on IL-6-mediated signaling cascades in human myeloma cells.
Liu S, Ma Z, Cai H, Li Q, Rong W, Kawano M
Eur J Haematol. 2010
PubMed ID: 19878271
Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency.
Peng L, Wu TT, Tchieu JH, Feng J, Brown HJ, Feng J, Li X, Qi J, Deng H, Vivanco I, Mellinghoff IK, Jamieson C, Sun R
J Gen Virol. 2010
PubMed ID: 19864499
Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1.
Brown C, LaRocca J, Pietruska J, Ota M, Anderson L, Smith SD, Weston P, Rasoulpour T, Hixon ML
Biol Reprod. 2010
PubMed ID: 19794155
PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.
Saavedra A, García-Martínez JM, Xifró X, Giralt A, Torres-Peraza JF, Canals JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E
Cell Death Differ. 2010
PubMed ID: 19745829
Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK.
Schmidt M, Voelker HU, Kapp M, Krockenberger M, Dietl J, Kammerer U
J Cancer Res Clin Oncol. 2010
PubMed ID: 19655166
UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes.
Ming M, Han W, Maddox J, Soltani K, Shea CR, Freeman DM, He YY
Oncogene. 2010
PubMed ID: 19881543
The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.
Kurabe N, Mori M, Kurokawa J, Taniguchi K, Aoyama H, Atsuda K, Nishijima A, Odawara N, Harada S, Nakashima K, Arai S, Miyazaki T
Biochem Biophys Res Commun. 2010
PubMed ID: 20043882
Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane.
Ng Y, Ramm G, Burchfield JG, Coster AC, Stöckli J, James DE
J Biol Chem. 2010
PubMed ID: 19897488
Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA
J Biol Chem. 2010
PubMed ID: 19889640
PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
Peng C, Chen Y, Yang Z, Zhang H, Osterby L, Rosmarin AG, Li S
Blood. 2010
PubMed ID: 19965668
Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.
Robinson JP, VanBrocklin MW, Guilbeault AR, Signorelli DL, Brandner S, Holmen SL
Oncogene. 2010
PubMed ID: 19855433
Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production.
Basu A, Hoerning A, Datta D, Edelbauer M, Stack MP, Calzadilla K, Pal S, Briscoe DM
J Immunol. 2010
PubMed ID: 20008289
Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism.
Roman EA, Reis D, Romanatto T, Maimoni D, Ferreira EA, Santos GA, Torsoni AS, Velloso LA, Torsoni MA
Mol Cell Endocrinol. 2010
PubMed ID: 19698760
Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft.
Bhola P, Banerjee S, Mukherjee J, Balasubramanium A, Arun V, Karim Z, Burrell K, Croul S, Gutmann DH, Guha A
Int J Cancer. 2010
PubMed ID: 19634141
Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer.
Uddin S, Ahmed M, Hussain A, Assad L, Al-Dayel F, Bavi P, Al-Kuraya KS, Munkarah A
Int J Cancer. 2010
PubMed ID: 19621391
Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways.
Ghayad SE, Vendrell JA, Larbi SB, Dumontet C, Bieche I, Cohen PA
Int J Cancer. 2010
PubMed ID: 19609946
Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma.
Oy GF, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo GM, Flørenes VA
Int J Cancer. 2010
PubMed ID: 19588500
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling.
Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J, Siow D, Lane AN, Brock SE, Goswami U, Eaton JW, Telang S, Chesney J
Oncogene. 2010
PubMed ID: 19855431
Akt promotes chemoresistance in human ovarian cancer cells by modulating cisplatin-induced, p53-dependent ubiquitination of FLICE-like inhibitory protein.
Abedini MR, Muller EJ, Bergeron R, Gray DA, Tsang BK
Oncogene. 2010
PubMed ID: 19802016
AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.
Askham JM, Platt F, Chambers PA, Snowden H, Taylor CF, Knowles MA
Oncogene. 2010
PubMed ID: 19802009
Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow.
Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, Pepe AE, Wang G, Habi O, deFalco E, Cockerill G, Mason JC, Hu Y, Xu Q
Circulation. 2010
PubMed ID: 20026773
Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer.
Kim JG, Chae YS, Sohn SK, Kang BW, Moon JH, Lee SJ, Jeon SW, Park JS, Park JY, Choi GS
Oncology. 2010
PubMed ID: 21412012
Correlation between Mcl-1 and pAKT protein expression in colorectal cancer.
Henderson-Jackson EB, Helm J, Ghayouri M, Hakam A, Nasir A, Leon M, Bui M, Yeatman T, Coppola D
Int J Clin Exp Pathol. 2010
PubMed ID: 21151390
COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer.
Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, Goodman JE, Yfantis HG, Lee DH, Ambs S
BMC Cancer. 2010
PubMed ID: 21078168
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA
Sci Signal. 2010
PubMed ID: 21062993
Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion.
Ye S, Hao X, Zhou T, Wu M, Wei J, Wang Y, Zhou L, Jiang X, Ji L, Chen Y, You L, Zhang Y, Xu G, Zhou J, Ma D, Wang S
BMC Cancer. 2010
PubMed ID: 21059203
Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.
Covey TM, Edes K, Coombs GS, Virshup DM, Fitzpatrick FA
PLoS One. 2010
PubMed ID: 20975834
Casein kinase 2 dependent phosphorylation of neprilysin regulates receptor tyrosine kinase signaling to Akt.
Siepmann M, Kumar S, Mayer G, Walter J
PLoS One. 2010
PubMed ID: 20957047
Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition.
Wu WI, Voegtli WC, Sturgis HL, Dizon FP, Vigers GP, Brandhuber BJ
PLoS One. 2010
PubMed ID: 20886116
Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.
Goncalves MD, Pistilli EE, Balduzzi A, Birnbaum MJ, Lachey J, Khurana TS, Ahima RS
PLoS One. 2010
PubMed ID: 20856813
Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer.
Chen J, Gomes AR, Monteiro LJ, Wong SY, Wu LH, Ng TT, Karadedou CT, Millour J, Ip YC, Cheung YN, Sunters A, Chan KY, Lam EW, Khoo US
PLoS One. 2010
PubMed ID: 20808831
Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination.
Bremer J, O'Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A
PLoS One. 2010
PubMed ID: 20805985
Decoupling of receptor and downstream signals in the Akt pathway by its low-pass filter characteristics.
Fujita KA, Toyoshima Y, Uda S, Ozaki Y, Kubota H, Kuroda S
Sci Signal. 2010
PubMed ID: 20664065
miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics.
Bar N, Dikstein R
PLoS One. 2010
PubMed ID: 20523723
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
Sei Y, Li Z, Song J, Ren-Patterson R, Tunbridge EM, Iizuka Y, Inoue M, Alfonso BT, Beltaifa S, Nakai Y, Kolachana BS, Chen J, Weinberger DR
PLoS One. 2010
PubMed ID: 20520724
Hyperactivity and enhanced curiosity of mice expressing PKB/SGK-resistant glycogen synthase kinase-3 (GSK-3).
Ackermann TF, Kempe DS, Lang F, Lang UE
Cell Physiol Biochem. 2010
PubMed ID: 20511724
Antiproliferative effect of growth hormone-releasing hormone (GHRH) antagonist on ovarian cancer cells through the EGFR-Akt pathway.
Guo J, Schally AV, Zarandi M, Varga J, Leung PC
Reprod Biol Endocrinol. 2010
PubMed ID: 20509930
Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas.
Li Z, Qi CF, Shin DM, Zingone A, Newbery HJ, Kovalchuk AL, Abbott CM, Morse HC
PLoS One. 2010
PubMed ID: 20505761
PI3K/Akt promotes GRP78 accumulation and inhibits endoplasmic reticulum stress-induced apoptosis in HEK293 cells.
Dai RY, Chen SK, Yan DM, Chen R, Lui YP, Duan CY, Li J, He T, Li H
Folia Biol (Praha). 2010
PubMed ID: 20492754
Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line.
Chai H, Luo AZ, Weerasinghe P, Brown RE
Int J Clin Exp Pathol. 2010
PubMed ID: 20490331
The masticatory contractile load induced expression and activation of Akt1/PKBalpha in muscle fibers at the myotendinous junction within muscle-tendon-bone unit.
Korkmaz Y, Klinz FJ, Moghbeli M, Addicks K, Raab WH, Bloch W
J Biomed Biotechnol. 2010
PubMed ID: 20454577
Upregulation of PTEN in glioma cells by cord blood mesenchymal stem cells inhibits migration via downregulation of the PI3K/Akt pathway.
Dasari VR, Kaur K, Velpula KK, Gujrati M, Fassett D, Klopfenstein JD, Dinh DH, Rao JS
PLoS One. 2010
PubMed ID: 20436671
[The effect of angiotensin II on phosphoinositide-3 kinase/Akt cascade in cultured fibroblasts derived from patients with hypertrophic scars]
Liu HW, Cheng B, Wu HJ, Gu YF, Chen X, Chen ZG, Liu WZ
Zhonghua Zheng Xing Wai Ke Za Zhi. 2010
PubMed ID: 20432929
[The roles of PI3K/Akt pathway in proliferation of Schwann cells promoted by pyrroloquinoline quinone]
He B, Liu SQ, Li HH
Zhonghua Zheng Xing Wai Ke Za Zhi. 2010
PubMed ID: 20432928
Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells.
Xu J, Zhou JY, Wei WZ, Wu GS
PLoS One. 2010
PubMed ID: 20419107
Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC Genet. 2010
PubMed ID: 20416077
Higher pAkt expression predicts a significant worse prognosis in glioblastomas.
Suzuki Y, Shirai K, Oka K, Mobaraki A, Yoshida Y, Noda SE, Okamoto M, Suzuki Y, Itoh J, Itoh H, Ishiuchi S, Nakano T
J Radiat Res (Tokyo). 2010
PubMed ID: 20410674
Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts.
Wickenden JA, Watson CJ
Breast Cancer Res. 2010
PubMed ID: 20398329
Clinical significance of PTEN and p-Akt co-expression in HER2-positive metastatic breast cancer patients treated with trastuzumab-based therapies.
Fabi A, Metro G, Di Benedetto A, Nisticò C, Vici P, Melucci E, Antoniani B, Perracchio L, Sperduti I, Milella M, Cognetti F, Mottolese M
Oncology. 2010
PubMed ID: 20389136
Angiotensin II inhibits insulin-stimulated GLUT4 translocation and Akt activation through tyrosine nitration-dependent mechanisms.
Csibi A, Communi D, Müller N, Bottari SP
PLoS One. 2010
PubMed ID: 20383279
Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.
He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W
Sci Signal. 2010
PubMed ID: 20371769
Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB
PLoS One. 2010
PubMed ID: 20361045
Myricetin inhibits Akt survival signaling and induces Bad-mediated apoptosis in a low dose ultraviolet (UV)-B-irradiated HaCaT human immortalized keratinocytes.
Kim W, Yang HJ, Youn H, Yun YJ, Seong KM, Youn B
J Radiat Res (Tokyo). 2010
PubMed ID: 20339252
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP
PLoS One. 2010
PubMed ID: 20333297
Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway.
Kim D, Shu S, Coppola MD, Kaneko S, Yuan ZQ, Cheng JQ
PLoS One. 2010
PubMed ID: 20231902
Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage.
García S, Liz M, Gómez-Reino JJ, Conde C
Arthritis Res Ther. 2010
PubMed ID: 20187936
[Expressions of phospho-Erk1/2 and phospho-Akt1 in the corpus cavernosum of spontaneous hypertensive rats]
Mao JB, Xu CX, Jiang R
Zhonghua Nan Ke Xue. 2010
PubMed ID: 20180400
Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.
Wang Y, Sun M, Uhlhorn VL, Zhou X, Peter I, Martinez-Abadias N, Hill CA, Percival CJ, Richtsmeier JT, Huso DL, Jabs EW
BMC Dev Biol. 2010
PubMed ID: 20175913
Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models.
Blanco-Aparicio C, Cañamero M, Cecilia Y, Pequeño B, Renner O, Ferrer I, Carnero A
PLoS One. 2010
PubMed ID: 20174572
[Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism].
Wang WP, Shi ZQ, Yu JH, Guo L, Wang L, Han DL, Yuan DC, Zang YZ
Nan Fang Yi Ke Da Xue Xue Bao. 2010
PubMed ID: 20117987
Molecular alterations in AKT1, AKT2 and AKT3 detected in breast and prostatic cancer by FISH.
Kirkegaard T, Witton CJ, Edwards J, Nielsen KV, Jensen LB, Campbell FM, Cooke TG, Bartlett JM
Histopathology. 2010
PubMed ID: 20102399
Expanding the substantial interactome of NEMO using protein microarrays.
Fenner BJ, Scannell M, Prehn JH
PLoS One. 2010
PubMed ID: 20098747
Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.
Rodgers JT, Haas W, Gygi SP, Puigserver P
Cell Metab. 2010
PubMed ID: 20074525
An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Zillhardt M, Christensen JG, Lengyel E
Neoplasia. 2010
PubMed ID: 20072648
Shear stress activates Akt during vascular smooth muscle cell reorientation.
Rice KM, Kakarla SK, Mupparaju SP, Paturi S, Katta A, Wu M, Harris RT, Blough ER
Biotechnol Appl Biochem. 2010
PubMed ID: 20055757
Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways.
Yang F, Jove V, Xin H, Hedvat M, Van Meter TE, Yu H
Mol Cancer Res. 2010
PubMed ID: 20053726
Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth.
Baryawno N, Sveinbjörnsson B, Eksborg S, Chen CS, Kogner P, Johnsen JI
Cancer Res. 2010
PubMed ID: 20028853
ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB.
Park JK, Park SH, So K, Bae IH, Yoo YD, Um HD
Int J Oncol. 2010
PubMed ID: 19956847
Hypoxia switches glucose depletion-induced necrosis to phosphoinositide 3-kinase/Akt-dependent apoptosis in A549 lung adenocarcinoma cells.
Kim CH, Ko AR, Lee SY, Jeon HM, Kim SM, Park HG, Han SI, Kang HS
Int J Oncol. 2010
PubMed ID: 19956840
Nerve growth factor mediated SH2-Bbeta/Akt signal pathway activated in allergic airway challenge in mice.
Liu Y, Zhang B, Zhang S, Qi J, Zhang Z, Liu L, Fang X
Respirology. 2010
PubMed ID: 19947990
Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules.
Yang HY, Kim J, Lee KY, Jang YS
Mol Immunol. 2010
PubMed ID: 19939451
High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast.
Troxell ML, Levine J, Beadling C, Warrick A, Dunlap J, Presnell A, Patterson J, Shukla A, Olson NR, Heinrich MC, Corless CL
Mod Pathol. 2010
PubMed ID: 19898424
Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease.
Barazzoni R, Zhu X, Deboer M, Datta R, Culler MD, Zanetti M, Guarnieri G, Marks DL
Kidney Int. 2010
PubMed ID: 19890275
Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.
Lee DY, Li YS, Chang SF, Zhou J, Ho HM, Chiu JJ, Chien S
J Biol Chem. 2010
PubMed ID: 19889638
IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells.
Wei B, Baker S, Wieckiewicz J, Wood KJ
Am J Transplant. 2010
PubMed ID: 19889125
Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation.
Sonderegger S, Haslinger P, Sabri A, Leisser C, Otten JV, Fiala C, Knöfler M
Endocrinology. 2010
PubMed ID: 19887570
Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1.
Reiter CE, Kim JA, Quon MJ
Endocrinology. 2010
PubMed ID: 19887561
AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.
Cohen Y, Shalmon B, Korach J, Barshack I, Fridman E, Rechavi G
Gynecol Oncol. 2010
PubMed ID: 19853286
Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells.
Robertson BW, Chellaiah MA
Exp Cell Res. 2010
PubMed ID: 19850036
TNFalpha induced oxidative stress dependent Akt signaling affects actin cytoskeletal organization in glioma cells.
Ghosh S, Tewari R, Dixit D, Sen E
Neurochem Int. 2010
PubMed ID: 19836430
BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.
Kang MH, Kim JS, Seo JE, Oh SC, Yoo YA
Exp Cell Res. 2010
PubMed ID: 19835871
Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt.
Mannell H, Hammitzsch A, Mettler R, Pohl U, Krötz F
Cell Signal. 2010
PubMed ID: 19781633
Chronic myeloid leukemia and BCR/ABL signal pathways are not associated with AKT1 pleckstrin homology domain (E17K) mutations.
He Y, Zheng J, Hu Y, Xiao H, Liu J, Li X, Du W, Chen X, Hu Y, Huang S
Eur J Haematol. 2010
PubMed ID: 19744127
The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.
Lin JE, Li P, Snook AE, Schulz S, Dasgupta A, Hyslop TM, Gibbons AV, Marszlowicz G, Pitari GM, Waldman SA
Gastroenterology. 2010
PubMed ID: 19737566
AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression.
Straszewski-Chavez SL, Abrahams VM, Aldo PB, Romero R, Mor G
Biol Reprod. 2010
PubMed ID: 19726736
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy.
Rane MJ, Song Y, Jin S, Barati MT, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein JB, Li X, Cai L
Am J Physiol Renal Physiol. 2010
PubMed ID: 19726550
Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition.
Zhuang J, Hawkins SF, Glenn MA, Lin K, Johnson GG, Carter A, Cawley JC, Pettitt AR
Haematologica. 2010
PubMed ID: 19713228
Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.
Watson JL, Greenshields A, Hill R, Hilchie A, Lee PW, Giacomantonio CA, Hoskin DW
Mol Carcinog. 2010
PubMed ID: 19676105
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.
Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D
Proc Natl Acad Sci U S A. 2009
PubMed ID: 20007774
Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells.
Moon DO, Kim MO, Lee JD, Choi YH, Kim GY
Cancer Lett. 2009
PubMed ID: 19560862
Wortmannin potentiates roscovitine-induced growth inhibition in human solid tumor cells by repressing PI3K/Akt pathway.
Zhang F, Zhang T, Jiang T, Zhang R, Teng ZH, Li C, Gu ZP, Mei Q
Cancer Lett. 2009
PubMed ID: 19541408
The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.
Band AM, Björklund M, Laiho M
J Biol Chem. 2009
PubMed ID: 19875456
Akt signal transduction dysfunction in Parkinson's disease.
Timmons S, Coakley MF, Moloney AM, O' Neill C
Neurosci Lett. 2009
PubMed ID: 19800394
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways.
Mamidipudi V, Cartwright CA
Oncogene. 2009
PubMed ID: 19767770
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.
Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ
J Cell Sci. 2009
PubMed ID: 19934221
Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice.
Matsui N, Takahashi K, Takeichi M, Kuroshita T, Noguchi K, Yamazaki K, Tagashira H, Tsutsui K, Okada H, Kido Y, Yasui Y, Fukuishi N, Fukuyama Y, Akagi M
Brain Res. 2009
PubMed ID: 19815000
Vascular endothelial growth factor promotes cardiac stem cell migration via the PI3K/Akt pathway.
Tang J, Wang J, Kong X, Yang J, Guo L, Zheng F, Zhang L, Huang Y, Wan Y
Exp Cell Res. 2009
PubMed ID: 19800880
Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.
Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G
J Biol Chem. 2009
PubMed ID: 19815552
Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets.
Kim S, Mangin P, Dangelmaier C, Lillian R, Jackson SP, Daniel JL, Kunapuli SP
J Biol Chem. 2009
PubMed ID: 19700402
Phosphatidylinositol 3-kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells.
Okazaki H, Shioi A, Hirowatari K, Koyama H, Fukumoto S, Ishimura E, Nishizawa Y
Osaka City Med J. 2009
PubMed ID: 20088406
The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.
Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura AJ, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M
Dev Cell. 2009
PubMed ID: 20059950
CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells.
Roca H, Varsos ZS, Pienta KJ
Neoplasia. 2009
PubMed ID: 20019839
Nuclear magnetic resonance detects phosphoinositide 3-kinase/Akt-independent traits common to pluripotent murine embryonic stem cells and their malignant counterparts.
Romanska HM, Tiziani S, Howe RC, Günther UL, Gulzar Z, Lalani el-N
Neoplasia. 2009
PubMed ID: 20019838
Human immunodeficiency virus type 1 Tat accelerates Kaposi sarcoma-associated herpesvirus Kaposin A-mediated tumorigenesis of transformed fibroblasts in vitro as well as in nude and immunocompetent mice.
Chen X, Cheng L, Jia X, Zeng Y, Yao S, Lv Z, Qin D, Fang X, Lei Y, Lu C
Neoplasia. 2009
PubMed ID: 20019835
Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells.
Miller TW, Forbes JT, Shah C, Wyatt SK, Manning HC, Olivares MG, Sanchez V, Dugger TC, de Matos Granja N, Narasanna A, Cook RS, Kennedy JP, Lindsley CW, Arteaga CL
Clin Cancer Res. 2009
PubMed ID: 19934303
Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo.
Zhang J, Zhang QY, Fu YC, Wang T, Zhang J, Xu P, Zhou X, Pu PY, Kang CS
Technol Cancer Res Treat. 2009
PubMed ID: 19925030
Calcium-independent phospholipase A2beta-Akt signaling is involved in lipopolysaccharide-induced NADPH oxidase 1 expression and foam cell formation.
Lee SH, Park DW, Park SC, Park YK, Hong SY, Kim JR, Lee CH, Baek SH
J Immunol. 2009
PubMed ID: 19917703
Suppression of Akt1 expression by small interference RNA inhibits SGC7901 cell growth in vitro and in vivo.
Cui XW, Zhao FJ, Liu J, Song XM, Xu P, Zhou X, Zhang J, Wang T, Kang CS, Zhang QY
Oncol Rep. 2009
PubMed ID: 19885581
Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK.
Shin DY, Lee WS, Lu JN, Kang MH, Ryu CH, Kim GY, Kang HS, Shin SC, Choi YH
Int J Oncol. 2009
PubMed ID: 19885574
Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction.
Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L
J Clin Invest. 2009
PubMed ID: 19884655
Genetic variations in PI3K-AKT-mTOR pathway and bladder cancer risk.
Chen M, Cassidy A, Gu J, Delclos GL, Zhen F, Yang H, Hildebrandt MA, Lin J, Ye Y, Chamberlain RM, Dinney CP, Wu X
Carcinogenesis. 2009
PubMed ID: 19875696
Mechanisms involved in 3',5'-cyclic adenosine monophosphate-mediated inhibition of the ubiquitin-proteasome system in skeletal muscle.
Gonçalves DA, Lira EC, Baviera AM, Cao P, Zanon NM, Arany Z, Bedard N, Tanksale P, Wing SS, Lecker SH, Kettelhut IC, Navegantes LC
Endocrinology. 2009
PubMed ID: 19837877
Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors.
Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y, Fan GC
Stem Cells. 2009
PubMed ID: 19816949
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
de Frias M, Iglesias-Serret D, Cosialls AM, Coll-Mulet L, Santidrián AF, González-Gironès DM, de la Banda E, Pons G, Gil J
Haematologica. 2009
PubMed ID: 19815839
Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.
Swiercz JM, Worzfeld T, Offermanns S
Mol Cell Biol. 2009
PubMed ID: 19805522
Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway.
Wen J, Xia Q, Wang C, Liu W, Chen Y, Gao J, Gong Y, Yin B, Ke Y, Qiang B, Yuan J, Peng X
J Mol Cell Cardiol. 2009
PubMed ID: 19800350
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.
Li X, Liu J, Gao T
Mol Cell Biol. 2009
PubMed ID: 19797085
Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.
Scott NJ, Ellmers LJ, Lainchbury JG, Maeda N, Smithies O, Richards AM, Cameron VA
Biochim Biophys Acta. 2009
PubMed ID: 19782130
The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells.
Werden SJ, Lanchbury J, Shattuck D, Neff C, Dufford M, McFadden G
J Virol. 2009
PubMed ID: 19776120
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.
Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19762778
Thyroid-hormone-dependent activation of the phosphoinositide 3-kinase/Akt cascade requires Src and enhances neuronal survival.
Cao X, Kambe F, Yamauchi M, Seo H
Biochem J. 2009
PubMed ID: 19747164
GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.
Giovannone B, Tsiaras WG, de la Monte S, Klysik J, Lautier C, Karashchuk G, Goldwurm S, Smith RJ
Hum Mol Genet. 2009
PubMed ID: 19744960
Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase.
Uliczka F, Kornprobst T, Eitel J, Schneider D, Dersch P
Cell Microbiol. 2009
PubMed ID: 19681907
The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification.
Ulici V, Hoenselaar KD, Agoston H, McErlain DD, Umoh J, Chakrabarti S, Holdsworth DW, Beier F
Bone. 2009
PubMed ID: 19679212
Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway.
Koshikawa N, Hayashi J, Nakagawara A, Takenaga K
J Biol Chem. 2009
PubMed ID: 19801684
Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.
Ding J, Ning B, Gong W, Wen W, Wu K, Liang J, He G, Huang S, Sun W, Han T, Huang L, Cao G, Wu M, Xie W, Wang H
J Biol Chem. 2009
PubMed ID: 19801633
DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis.
Xie D, Gore C, Zhou J, Pong RC, Zhang H, Yu L, Vessella RL, Min W, Hsieh JT
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19903888
Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH
J Immunol. 2009
PubMed ID: 19841181
Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranes.
Romanelli RJ, Mahajan KR, Fulmer CG, Wood TL
J Neurosci Res. 2009
PubMed ID: 19382214
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
Zhou R, Niwa S, Homma N, Takei Y, Hirokawa N
Cell. 2009
PubMed ID: 19914172
The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats.
Wang HY, Wang GL, Yu YH, Wang Y
Brain Res. 2009
PubMed ID: 19703434
Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts.
Matheny RW, Adamo ML
Biochem Biophys Res Commun. 2009
PubMed ID: 19703413
Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.
Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19850877
[Change from inflammation to carcinoma in ulcerative colitis: the role of PTEN/PI3K/AKT].
Fu DG, Huang XL, Gan HT, Zhang DK, Zhao LQ
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 20067111
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock.
Inoue H, Ndong M, Suzuki T, Kazami M, Uyama T, Kobayashi K, Tadokoro T, Yamamoto Y
Biosci Biotechnol Biochem. 2009
PubMed ID: 19897899
Insulin-like growth factor-I-induced androgen receptor activation is mediated by the PI3K/Akt pathway in C2C12 skeletal muscle cells.
Lee WJ
Mol Cells. 2009
PubMed ID: 19855934
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.
Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V
Nat Neurosci. 2009
PubMed ID: 19838179
Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiation.
Mandal CC, Ghosh Choudhury G, Ghosh-Choudhury N
Endocrinology. 2009
PubMed ID: 19819979
Immuno-analysis of phospho-Akt in primary human breast cancers.
Al-Bazz YO, Brown BL, Underwood JC, Stewart RL, Dobson PR
Int J Oncol. 2009
PubMed ID: 19787271
Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt.
Morissette MR, Cook SA, Buranasombati C, Rosenberg MA, Rosenzweig A
Am J Physiol Cell Physiol. 2009
PubMed ID: 19759331
Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells.
Nagl F, Schönhofer K, Seidler B, Mages J, Allescher HD, Schmid RM, Schneider G, Saur D
Am J Physiol Cell Physiol. 2009
PubMed ID: 19726747
17beta-Estradiol regulates the first steps of skeletal muscle cell differentiation via ER-alpha-mediated signals.
Galluzzo P, Rastelli C, Bulzomi P, Acconcia F, Pallottini V, Marino M
Am J Physiol Cell Physiol. 2009
PubMed ID: 19726745
Loss of enteric neurons accompanied by decreased expression of GDNF and PI3K/Akt pathway in diabetic rats.
Du F, Wang L, Qian W, Liu S
Neurogastroenterol Motil. 2009
PubMed ID: 19709371
Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.
Waugh C, Sinclair L, Finlay D, Bayascas JR, Cantrell D
Mol Cell Biol. 2009
PubMed ID: 19703999
Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.
El-Naggar S, Liu Y, Dean DC
Mol Cell Biol. 2009
PubMed ID: 19703998
Endothelial nitric oxide synthase is involved in calcium-induced Akt signaling in mouse skeletal muscle.
Drenning JA, Lira VA, Soltow QA, Canon CN, Valera LM, Brown DL, Criswell DS
Nitric Oxide. 2009
PubMed ID: 19682597
Adenosine A2a receptor induced gliosis via Akt/NF-kappaB pathway in vitro.
Ke RH, Xiong J, Liu Y, Ye ZR
Neurosci Res. 2009
PubMed ID: 19666061
Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation.
Carloni S, Girelli S, Buonocore G, Longini M, Balduini W
Exp Neurol. 2009
PubMed ID: 19664625
Influence of zinc deficiency on Akt-Mdm2-p53 and Akt-p21 signaling axes in normal and malignant human prostate cells.
Han CT, Schoene NW, Lei KY
Am J Physiol Cell Physiol. 2009
PubMed ID: 19657064
Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling.
Park SJ, Kim SH, Choi HS, Rhee Y, Lim SK
Bone. 2009
PubMed ID: 19631775
W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac.
Sirangelo I, Iannuzzi C, Vilasi S, Irace G, Giuberti G, Misso G, D'Alessandro A, Abbruzzese A, Caraglia M
J Cell Physiol. 2009
PubMed ID: 19585524
The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.
Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC
Mol Carcinog. 2009
PubMed ID: 19526459
Involvement of Akt1/protein kinase Balpha in tumor conditioned medium-induced endothelial cell migration and survival in vitro.
Tu ML, Wang HQ, Chen LJ, Lu JC, Jiang F, Liang JH, Xu da G, Li DS
J Cancer Res Clin Oncol. 2009
PubMed ID: 19488783
PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells.
Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, Takahashi H, Wakasugi T, Takeyama H
Mol Cell Biochem. 2009
PubMed ID: 19437103
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.
Sos ML, Fischer S, Ullrich R, Peifer M, Heuckmann JM, Koker M, Heynck S, Stückrath I, Weiss J, Fischer F, Michel K, Goel A, Regales L, Politi KA, Perera S, Getlik M, Heukamp LC, Ansén S, Zander T, Beroukhim R, Kashkar H, Shokat KM, Sellers WR, Rauh D, Orr C, Hoeflich KP, Friedman L, Wong KK, Pao W, Thomas RK
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805051
Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport.
Kleiman E, Carter G, Ghansah T, Patel NA, Cooper DR
Biochem Biophys Res Commun. 2009
PubMed ID: 19686698
Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma.
Du XL, Yang H, Liu SG, Luo ML, Hao JJ, Zhang Y, Lin DC, Xu X, Cai Y, Zhan QM, Wang MR
Oncogene. 2009
PubMed ID: 19684620
Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor.
Vijayaraj P, Kröger C, Reuter U, Windoffer R, Leube RE, Magin TM
J Cell Biol. 2009
PubMed ID: 19841136
Integrin-linked kinase is an adaptor with essential functions during mouse development.
Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R
Nature. 2009
PubMed ID: 19829382
Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury.
Tiozzo C, De Langhe S, Yu M, Londhe VA, Carraro G, Li M, Li C, Xing Y, Anderson S, Borok Z, Bellusci S, Minoo P
Am J Respir Crit Care Med. 2009
PubMed ID: 19574443
PTEN and SHIP2 regulates PI3K/Akt pathway through focal adhesion kinase.
Gupta A, Dey CS
Mol Cell Endocrinol. 2009
PubMed ID: 19501627
Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.
Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G
J Biol Chem. 2009
PubMed ID: 19696029
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation.
Polzien L, Baljuls A, Rennefahrt UE, Fischer A, Schmitz W, Zahedi RP, Sickmann A, Metz R, Albert S, Benz R, Hekman M, Rapp UR
J Biol Chem. 2009
PubMed ID: 19667065
Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.
Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo YM, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, Sawada K
Blood. 2009
PubMed ID: 19641183
Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle.
Richmond SR, Touchberry CD, Gallagher PM
Appl Physiol Nutr Metab. 2009
PubMed ID: 19935854
[A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells].
Zhou WJ, Deng R, Feng GK, Zhu XF
Ai Zheng. 2009
PubMed ID: 19799812
Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways.
Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ
Neoplasia. 2009
PubMed ID: 19794963
Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.
O'Shaughnessy RF, Welti JC, Sully K, Byrne C
Development. 2009
PubMed ID: 19762425
Signaling pathways in adenoid cystic cancers: implications for treatment.
Gupta AK, Wilke WW, Taylor EN, Bodeker KL, Hoffman HT, Milhem MM, Buatti JM, Robinson RA
Cancer Biol Ther. 2009
PubMed ID: 19729990
Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis.
Jin N, Cho SN, Raso MG, Wistuba I, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Ludwig T, Jeong JW, DeMayo FJ
Development. 2009
PubMed ID: 19710174
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R
Development. 2009
PubMed ID: 19710172
Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages.
Deguchi JO, Yamazaki H, Aikawa E, Aikawa M
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19644051
Activation of phosphatidylinositol 3-kinase/protein kinase B by corticotropin-releasing factor in human monocytes.
Chandras C, Koutmani Y, Kokkotou E, Pothoulakis C, Karalis KP
Endocrinology. 2009
PubMed ID: 19628576
PTEN/AKT pathway involved in histone deacetylases inhibitor induced cell growth inhibition and apoptosis of oral squamous cell carcinoma cells.
Gan YH, Zhang S
Oral Oncol. 2009
PubMed ID: 19574087
P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons.
Fischer M, Pereira PM, Holtmann B, Simon CM, Hanauer A, Heisenberg M, Sendtner M
Mol Cell Neurosci. 2009
PubMed ID: 19555761
Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinoma.
Capodanno A, Camerini A, Orlandini C, Baldini E, Resta ML, Bevilacqua G, Collecchi P
Hum Pathol. 2009
PubMed ID: 19428048
Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.
Kim JG, Chae YS, Sohn SK, Moon JH, Ryoo HM, Bae SH, Kum Y, Jeon SW, Lim KH, Kang BM, Park IJ, Choi GS, Jun SH
Cancer Chemother Pharmacol. 2009
PubMed ID: 19219602
Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation.
Kulasekaran P, Scavone CA, Rogers DS, Arenberg DA, Thannickal VJ, Horowitz JC
Am J Respir Cell Mol Biol. 2009
PubMed ID: 19188658
The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors.
Meima ME, Webb BA, Witkowska HE, Barber DL
J Biol Chem. 2009
PubMed ID: 19622752
Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M
Neuron. 2009
PubMed ID: 19778507
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL
Neuron. 2009
PubMed ID: 19778506
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia.
Edwards H, Xie C, LaFiura KM, Dombkowski AA, Buck SA, Boerner JL, Taub JW, Matherly LH, Ge Y
Blood. 2009
PubMed ID: 19638627
Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells.
Dai J, Peng L, Fan K, Wang H, Wei R, Ji G, Cai J, Lu B, Li B, Zhang D, Kang Y, Tan M, Qian W, Guo Y
Oncogene. 2009
PubMed ID: 19597469
Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells.
Yang CM, Hsieh HL, Yao CC, Hsiao LD, Tseng CP, Wu CB
J Biol Chem. 2009
PubMed ID: 19633290
Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients.
Kishi T, Tsunoka T, Ikeda M, Kitajima T, Kawashima K, Okochi T, Okumura T, Yamanouchi Y, Kinoshita Y, Ujike H, Inada T, Yamada M, Uchimura N, Sora I, Iyo M, Ozaki N, Iwata N
Neuropharmacology. 2009
PubMed ID: 19747927
Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.
Jang SW, Liu X, Fu H, Rees H, Yepes M, Levey A, Ye K
J Biol Chem. 2009
PubMed ID: 19592491
Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation.
Oussaief L, Hippocrate A, Ramirez V, Rampanou A, Zhang W, Meyers D, Cole P, Khelifa R, Joab I
J Biol Chem. 2009
PubMed ID: 19589780
Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway.
Liu CJ, Lo JF, Kuo CH, Chu CH, Chen LM, Tsai FJ, Tsai CH, Tzang BS, Kuo WW, Huang CY
J Cell Mol Med. 2009
PubMed ID: 20196785
Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus.
De Falco E, Avitabile D, Totta P, Straino S, Spallotta F, Cencioni C, Torella AR, Rizzi R, Porcelli D, Zacheo A, Di Vito L, Pompilio G, Napolitano M, Melillo G, Capogrossi MC, Pesce M
J Cell Mol Med. 2009
PubMed ID: 20196780
7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells.
Green JM, Alvero AB, Kohen F, Mor G
Cancer Biol Ther. 2009
PubMed ID: 19738422
Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells.
Xiao-Yun X, Zhuo-Xiong C, Min-Xiang L, Xingxuan H, Schuchman EH, Feng L, Han-Song X, An-Hua L
Med Sci Monit. 2009
PubMed ID: 19721393
Inside life of melanoma cell signaling, molecular insights, and therapeutic targets.
Sosman JA, Margolin KA
Curr Oncol Rep. 2009
PubMed ID: 19679016
Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion.
Kang MH, Kang HN, Kim JL, Kim JS, Oh SC, Yoo YA
Oncol Rep. 2009
PubMed ID: 19639199
Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo.
Fu Y, Zhang Q, Kang C, Zhang K, Zhang J, Pu P, Wang G, Wang T
Int J Oncol. 2009
PubMed ID: 19639178
Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs.
Silva GB, Garvin JL
Am J Physiol Renal Physiol. 2009
PubMed ID: 19570880
Promising molecular targets in ovarian cancer.
Blagden S, Gabra H
Curr Opin Oncol. 2009
PubMed ID: 19553815
An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris.
Pretel M, España A, Marquina M, Pelacho B, López-Picazo JM, López-Zabalza MJ
Exp Dermatol. 2009
PubMed ID: 19552768
ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.
Cao J, Xu D, Wang D, Wu R, Zhang L, Zhu H, He Q, Yang B
Free Radic Biol Med. 2009
PubMed ID: 19482076
Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study.
Pontes HA, de Aquino Xavier FC, da Silva TS, Fonseca FP, Paiva HB, Pontes FS, dos Santos Pinto D
J Oral Pathol Med. 2009
PubMed ID: 19453843
Colitis induces calcitonin gene-related peptide expression and Akt activation in rat primary afferent pathways.
Qiao LY, Grider JR
Exp Neurol. 2009
PubMed ID: 19422825
Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways.
Tsuda M, Toyomitsu E, Kometani M, Tozaki-Saitoh H, Inoue K
J Cell Mol Med. 2009
PubMed ID: 19298529
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
Science. 2009
PubMed ID: 19713527
Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signaling.
Suh EJ, Kim YJ, Kim SH
Biochem Biophys Res Commun. 2009
PubMed ID: 19538940
Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway.
Ouyang G, Liu M, Ruan K, Song G, Mao Y, Bao S
Cancer Lett. 2009
PubMed ID: 19328625
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.
Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19622728
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs.
Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C
Immunity. 2009
PubMed ID: 19699171
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality.
Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM, Chen J
Circulation. 2009
PubMed ID: 19652092
[Changes in proliferative activity of myoblasts and expression of Akt in skeletal muscle of rats after severe burn injury].
Duan HJ, Chai JK, Sheng ZY, Liang LM, Yin HN, Shen CA
Zhonghua Wai Ke Za Zhi. 2009
PubMed ID: 19781178
Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, focal adhesion kinase, Akt, and AP-1- dependent pathway.
Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM, Tzeng CY, Lee TS, Hsu HC, Tang CH
J Immunol. 2009
PubMed ID: 19635908
Elevated levels of IL-1beta in Fanconi anaemia group A patients due to a constitutively active phosphoinositide 3-kinase-Akt pathway are capable of promoting tumour cell proliferation.
Ibáñez A, Río P, Casado JA, Bueren JA, Fernández-Luna JL, Pipaón C
Biochem J. 2009
PubMed ID: 19473116
Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoforms.
Hirano I, Nakamura S, Yokota D, Ono T, Shigeno K, Fujisawa S, Shinjo K, Ohnishi K
J Biol Chem. 2009
PubMed ID: 19261608
Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways.
Chung S, Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
Oncogene. 2009
PubMed ID: 19483721
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.
Wegiel B, Baty CJ, Gallo D, Csizmadia E, Scott JR, Akhavan A, Chin BY, Kaczmarek E, Alam J, Bach FH, Zuckerbraun BS, Otterbein LE
J Biol Chem. 2009
PubMed ID: 19509285
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
Oishi K, Watatani K, Itoh Y, Okano H, Guillemot F, Nakajima K, Gotoh Y
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19549840
[Effects of SHIP gene mutation on cell cycle related proteins and phosphorylated Akt in K562 cells].
Yang L, Luo JM, Liu XJ, Wen SP, Yang JC, Zhang JY
Zhonghua Xue Ye Xue Za Zhi. 2009
PubMed ID: 19954644
Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathways.
Zhang Z, Song T, Jin Y, Pan J, Zhang L, Wang L, Li P
Int J Gynecol Cancer. 2009
PubMed ID: 19820359
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Kim SH, Kim SH, Kim YB, Jeon YT, Lee SC, Song YS
Ann N Y Acad Sci. 2009
PubMed ID: 19723095
Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells.
Lee YK, Park SY, Kim YM, Park OJ
Ann N Y Acad Sci. 2009
PubMed ID: 19723094
Wortmannin inhibits K562 leukemic cells by regulating PI3k/Akt channel in vitro.
Wu Q, Chen Y, Cui G, Cheng Y
J Huazhong Univ Sci Technolog Med Sci. 2009
PubMed ID: 19662361
Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth.
Barros CS, Nguyen T, Spencer KS, Nishiyama A, Colognato H, Müller U
Development. 2009
PubMed ID: 19633169
FGFR2 is associated with hair thickness in Asian populations.
Fujimoto A, Nishida N, Kimura R, Miyagawa T, Yuliwulandari R, Batubara L, Mustofa MS, Samakkarn U, Settheetham-Ishida W, Ishida T, Morishita Y, Tsunoda T, Tokunaga K, Ohashi J
J Hum Genet. 2009
PubMed ID: 19590514
An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation.
Di Vizio D, Morello M, Sotgia F, Pestell RG, Freeman MR, Lisanti MP
Cell Cycle. 2009
PubMed ID: 19556867
Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy.
Wu YT, Tan HL, Huang Q, Ong CN, Shen HM
Autophagy. 2009
PubMed ID: 19556857
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.
Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD
J Physiol. 2009
PubMed ID: 19505983
Partially purified Curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells.
Jang JY, Lee JH, Jeong SY, Chung KT, Choi YH, Choi BT
Exp Dermatol. 2009
PubMed ID: 19469902
Expression of selected tumor suppressor and oncogenes in endometrium of women with endometriosis.
Laudanski P, Szamatowicz J, Kowalczuk O, Kuźmicki M, Grabowicz M, Chyczewski L
Hum Reprod. 2009
PubMed ID: 19429661
Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression.
Pang B, Zhang H, Wang J, Chen WZ, Li SH, Shi QG, Liang RX, Xie BX, Wu RQ, Qian XL, Yu L, Li QM, Huang CF, Zhou JG
Prostate. 2009
PubMed ID: 19415690
Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.
Banu SK, Lee J, Speights VO, Starzinski-Powitz A, Arosh JA
Mol Endocrinol. 2009
PubMed ID: 19407222
Platelet lysate promotes in vitro wound scratch closure of human dermal fibroblasts: different roles of cell calcium, P38, ERK and PI3K/AKT.
Ranzato E, Mazzucco L, Patrone M, Burlando B
J Cell Mol Med. 2009
PubMed ID: 19267882
Telmisartan induces proliferation of human endothelial progenitor cells via PPARgamma-dependent PI3K/Akt pathway.
Honda A, Matsuura K, Fukushima N, Tsurumi Y, Kasanuki H, Hagiwara N
Atherosclerosis. 2009
PubMed ID: 19193378
Expression of Akt and Mdm2 in human esophageal squamous cell carcinoma.
Takahashi K, Miyashita M, Makino H, Akagi I, Orita H, Hagiwara N, Nomura T, Gabrielson EW, Tajiri T
Exp Mol Pathol. 2009
PubMed ID: 19124015
Increased activated Akt expression in renal cell carcinomas and prognosis.
Hager M, Haufe H, Kemmerling R, Hitzl W, Mikuz G, Moser PL, Kolbitsch C
J Cell Mol Med. 2009
PubMed ID: 18774962
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Cdc42 and the phosphatidylinositol 3-kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cells.
Agarwal V, Hammerschmidt S
J Biol Chem. 2009
PubMed ID: 19473971
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT
Blood. 2009
PubMed ID: 19458356
Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival.
Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, Czerwitzki J, Metzger D, Steiner S, Wurst P, Leuschner I, von Schweinitz D, Buettner R, Pietsch T
Clin Cancer Res. 2009
PubMed ID: 19584164
TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling.
Liu C, Xu P, Lamouille S, Xu J, Derynck R
Mol Cell. 2009
PubMed ID: 19595713
The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas.
Shoji K, Oda K, Nakagawa S, Hosokawa S, Nagae G, Uehara Y, Sone K, Miyamoto Y, Hiraike H, Hiraike-Wada O, Nei T, Kawana K, Kuramoto H, Aburatani H, Yano T, Taketani Y
Br J Cancer. 2009
PubMed ID: 19491896
[The relationship between PTEN expression and PI3K/AKT signal pathway in colon carcinoma]
Qi JK, Huang XL, Meng ZM, Gan HT, Fu DG
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19764563
Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.
Jin XL, Chandrakanthan V, Morgan HD, O'Neill C
Biol Reprod. 2009
PubMed ID: 19630168
The insulin/Akt pathway controls a specific cell division program that leads to generation of binucleated tetraploid liver cells in rodents.
Celton-Morizur S, Merlen G, Couton D, Margall-Ducos G, Desdouets C
J Clin Invest. 2009
PubMed ID: 19603546
Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells.
Doan HQ, Bowen KA, Jackson LA, Evers BM
Anticancer Res. 2009
PubMed ID: 19596916
TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN.
Kato M, Putta S, Wang M, Yuan H, Lanting L, Nair I, Gunn A, Nakagawa Y, Shimano H, Todorov I, Rossi JJ, Natarajan R
Nat Cell Biol. 2009
PubMed ID: 19543271
Iron-saturated lactoferrin stimulates cell cycle progression through PI3K/Akt pathway.
Lee SH, Pyo CW, Hahm DH, Kim J, Choi SY
Mol Cells. 2009
PubMed ID: 19533041
An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons.
Jantas D, Szymanska M, Budziszewska B, Lason W
Apoptosis. 2009
PubMed ID: 19521778
Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells.
Riol-Blanco L, Delgado-Martín C, Sánchez-Sánchez N, Alonso-C LM, Gutiérrez-López MD, Del Hoyo GM, Navarro J, Sánchez-Madrid F, Cabañas C, Sánchez-Mateos P, Rodríguez-Fernández JL
Nat Immunol. 2009
PubMed ID: 19503105
Phosphorylation of ATXN1 at Ser776 in the cerebellum.
Jorgensen ND, Andresen JM, Lagalwar S, Armstrong B, Stevens S, Byam CE, Duvick LA, Lai S, Jafar-Nejad P, Zoghbi HY, Clark HB, Orr HT
J Neurochem. 2009
PubMed ID: 19500214
Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B.
Ries V, Cheng HC, Baohan A, Kareva T, Oo TF, Rzhetskaya M, Bland RJ, During MJ, Kholodilov N, Burke RE
J Neurochem. 2009
PubMed ID: 19490361
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR.
Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H
Nat Immunol. 2009
PubMed ID: 19483717
Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1.
Demers MJ, Thibodeau S, Noël D, Fujita N, Tsuruo T, Gauthier R, Arguin M, Vachon PH
J Cell Biochem. 2009
PubMed ID: 19479902
Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia.
Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G
Dis Model Mech. 2009
PubMed ID: 19470613
Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-kappaB-dependent pathways.
Jiang JX, Mikami K, Venugopal S, Li Y, Török NJ
J Hepatol. 2009
PubMed ID: 19457567
IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation.
Kolliputi N, Waxman AB
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19376889
A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ
Hum Mol Genet. 2009
PubMed ID: 19357198
The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice.
Peterson SJ, Kim DH, Li M, Positano V, Vanella L, Rodella LF, Piccolomini F, Puri N, Gastaldelli A, Kusmic C, L'Abbate A, Abraham NG
J Lipid Res. 2009
PubMed ID: 19224872
TGF-beta induces degradation of TAL1/SCL by the ubiquitin-proteasome pathway through AKT-mediated phosphorylation.
Terme JM, Lhermitte L, Asnafi V, Jalinot P
Blood. 2009
PubMed ID: 19406989
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ
Cancer Res. 2009
PubMed ID: 19491266
Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.
Kim Y, Kim K, Lee H, Han S, Lee YS, Choe J, Kim YM, Hahn JH, Ro JY, Jeoung D
Eur J Pharmacol. 2009
PubMed ID: 19356729
UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS.
Jee HJ, Kim HJ, Kim AJ, Bae YS, Bae SS, Yun J
Biochem Biophys Res Commun. 2009
PubMed ID: 19364500
Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
Korkaya H, Paulson A, Charafe-Jauffret E, Ginestier C, Brown M, Dutcher J, Clouthier SG, Wicha MS
PLoS Biol. 2009
PubMed ID: 19492080
AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia.
Joo EJ, Lee KY, Jeong SH, Roh MS, Kim SH, Ahn YM, Kim YS
Psychiatry Investig. 2009
PubMed ID: 20046382
PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis.
Zhou Y, Zhen H, Mei Y, Wang Y, Feng J, Xu S, Fu X
Cell Mol Immunol. 2009
PubMed ID: 19567200
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.
Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, Janakiraman M, Solit D, Knauf JA, Tuttle RM, Ghossein RA, Fagin JA
Cancer Res. 2009
PubMed ID: 19487299
Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling.
Neiva KG, Zhang Z, Miyazawa M, Warner KA, Karl E, Nör JE
Neoplasia. 2009
PubMed ID: 19484147
Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome.
Reed R, Potter B, Smith E, Jadhav R, Villalta P, Jo H, Rocic P
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19376806
Insulin attenuates the insulin-like growth factor-I (IGF-I)-Akt pathway, not IGF-I-extracellularly regulated kinase pathway, in luteinized granulosa cells with an increase in PTEN.
Iwase A, Goto M, Harata T, Takigawa S, Nakahara T, Suzuki K, Manabe S, Kikkawa F
J Clin Endocrinol Metab. 2009
PubMed ID: 19318457
Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).
Fischer DC, Jacoby U, Pape L, Ward CJ, Kuwertz-Broeking E, Renken C, Nizze H, Querfeld U, Rudolph B, Mueller-Wiefel DE, Bergmann C, Haffner D
Nephrol Dial Transplant. 2009
PubMed ID: 19176689
The level of AKT phosphorylation on threonine 308 but not on serine 473 is associated with high-risk cytogenetics and predicts poor overall survival in acute myeloid leukaemia.
Gallay N, Dos Santos C, Cuzin L, Bousquet M, Simmonet Gouy V, Chaussade C, Attal M, Payrastre B, Demur C, Récher C
Leukemia. 2009
PubMed ID: 19158829
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Sinnberg T, Lasithiotakis K, Niessner H, Schittek B, Flaherty KT, Kulms D, Maczey E, Campos M, Gogel J, Garbe C, Meier F
J Invest Dermatol. 2009
PubMed ID: 19078992
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
Brognard J, Niederst M, Reyes G, Warfel N, Newton AC
J Biol Chem. 2009
PubMed ID: 19324870
Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.
Narayanan SP, Flores AI, Wang F, Macklin WB
J Neurosci. 2009
PubMed ID: 19474313
Activation-induced degradation of FLIP(L) is mediated via the phosphatidylinositol 3-kinase/Akt signaling pathway in macrophages.
Shi B, Tran T, Sobkoviak R, Pope RM
J Biol Chem. 2009
PubMed ID: 19339247
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
An Akt/hypoxia-inducible factor-1alpha/platelet-derived growth factor-BB autocrine loop mediates hypoxia-induced chemoresistance in liver cancer cells and tumorigenic hepatic progenitor cells.
Lau CK, Yang ZF, Ho DW, Ng MN, Yeoh GC, Poon RT, Fan ST
Clin Cancer Res. 2009
PubMed ID: 19447872
Prognostic value of Akt-1 in human prostate cancer: a computerized quantitative assessment with quantum dot technology.
Li R, Dai H, Wheeler TM, Sayeeduddin M, Scardino PT, Frolov A, Ayala GE
Clin Cancer Res. 2009
PubMed ID: 19417030
Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression.
Zacharioudaki V, Androulidaki A, Arranz A, Vrentzos G, Margioris AN, Tsatsanis C
J Immunol. 2009
PubMed ID: 19414798
AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.
Lal MA, Bae D, Camilli TC, Patierno SR, Ceryak S
Cell Cycle. 2009
PubMed ID: 19377290
Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.
Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y, Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel A, Thomas G
Mol Cell. 2009
PubMed ID: 19481529
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED
Circ Res. 2009
PubMed ID: 19342603
PI3 kinase/Akt signaling mediates epithelial-mesenchymal transition in hypoxic hepatocellular carcinoma cells.
Yan W, Fu Y, Tian D, Liao J, Liu M, Wang B, Xia L, Zhu Q, Luo M
Biochem Biophys Res Commun. 2009
PubMed ID: 19303863
PI3K/Akt pathway mutations in Retinoblastoma.
Cohen Y, Merhavi-Shoham E, Avraham-Lubin BC, Savetsky M, Frenkel S, Pe'er J, Goldenberg-Cohen N
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19420344
Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma.
Dunlap J, Le C, Shukla A, Patterson J, Presnell A, Heinrich MC, Corless CL, Troxell ML
Breast Cancer Res Treat. 2009
PubMed ID: 19418217
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase.
Shineman DW, Dain AS, Kim ML, Lee VM
Biochemistry. 2009
PubMed ID: 19236051
[Effects of aging on the expressions of insulin receptor substrate-1, phosphate protein kinase B in rat liver and muscle]
Wang S, Meng ZM, Li XJ
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19626997
Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
Shin S, Asano T, Yao Y, Zhang R, Claret FX, Korc M, Sabapathy K, Menter DG, Abbruzzese JL, Reddy SA
Mol Cancer Res. 2009
PubMed ID: 19435822
APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.
Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A
Cell Metab. 2009
PubMed ID: 19416712
AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma.
Zilberman DE, Cohen Y, Amariglio N, Fridman E, Ramon J, Rechavi G
Cancer Genet Cytogenet. 2009
PubMed ID: 19389506
The steady-state expression of connexin43 is maintained by the PI3K/Akt in osteoblasts.
Bhattacharjee R, Kaneda M, Nakahama K, Morita I
Biochem Biophys Res Commun. 2009
PubMed ID: 19285956
Hydrogen peroxide-induced Akt phosphorylation regulates Bax activation.
Sadidi M, Lentz SI, Feldman EL
Biochimie. 2009
PubMed ID: 19278624
Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro.
Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ
J Biol Chem. 2009
PubMed ID: 19270310
Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis.
Liu J, Wang S, Zhang P, Said-Al-Naief N, Michalek SM, Feng X
J Biol Chem. 2009
PubMed ID: 19258321
The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy.
Luckey SW, Walker LA, Smyth T, Mansoori J, Messmer-Kratzsch A, Rosenzweig A, Olson EN, Leinwand LA
J Mol Cell Cardiol. 2009
PubMed ID: 19233194
Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver.
Guo R, Zhong L, Ren J
Clin Exp Pharmacol Physiol. 2009
PubMed ID: 19215238
KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.
Navenot JM, Fujii N, Peiper SC
Mol Pharmacol. 2009
PubMed ID: 19201817
Stathmin, a microtubule regulatory protein, is associated with hypoxia-inducible factor-1alpha levels in human endometrial and endothelial cells.
Yoshie M, Miyajima E, Kyo S, Tamura K
Endocrinology. 2009
PubMed ID: 19179443
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation.
Rotwein P, Wilson EM
J Cell Physiol. 2009
PubMed ID: 19142853
GADD45a is a novel candidate gene in inflammatory lung injury via influences on Akt signaling.
Meyer NJ, Huang Y, Singleton PA, Sammani S, Moitra J, Evenoski CL, Husain AN, Mitra S, Moreno-Vinasco L, Jacobson JR, Lussier YA, Garcia JG
FASEB J. 2009
PubMed ID: 19124556
Dystrophin glycoprotein complex-associated Gbetagamma subunits activate phosphatidylinositol-3-kinase/Akt signaling in skeletal muscle in a laminin-dependent manner.
Xiong Y, Zhou Y, Jarrett HW
J Cell Physiol. 2009
PubMed ID: 19117013
Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.
Guo D, Ye J, Dai J, Li L, Chen F, Ma D, Ji C
Leuk Res. 2009
PubMed ID: 19091404
Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids.
Singleton PA, Chatchavalvanich S, Fu P, Xing J, Birukova AA, Fortune JA, Klibanov AM, Garcia JG, Birukov KG
Circ Res. 2009
PubMed ID: 19286607
Bortezomib overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Chen KF, Yeh PY, Hsu C, Hsu CH, Lu YS, Hsieh HP, Chen PJ, Cheng AL
J Biol Chem. 2009
PubMed ID: 19261616
Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells.
Lee DH, Szczepanski MJ, Lee YJ
J Cell Biochem. 2009
PubMed ID: 19229860
Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation.
Walsh S, Gill C, O'Neill A, Fitzpatrick JM, Watson RW
Int J Cancer. 2009
PubMed ID: 19142871
Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
So HC, Fong PY, Chen RY, Hui TC, Ng MY, Cherny SS, Mak WW, Cheung EF, Chan RC, Chen EY, Li T, Sham PC
Am J Med Genet B Neuropsychiatr Genet. 2009
PubMed ID: 19367581
Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system.
Pereira JA, Benninger Y, Baumann R, Gonçalves AF, Ozçelik M, Thurnherr T, Tricaud N, Meijer D, Fässler R, Suter U, Relvas JB
J Cell Biol. 2009
PubMed ID: 19349584
Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway.
Mattioli B, Giordani L, Quaranta MG, Viora M
FEBS Lett. 2009
PubMed ID: 19250936
[Inhibitory effect of lentiviral vector-mediated SHIP gene transfection on proliferation of leukemia K562 cells and PI3K/Akt pathway regulation].
Yang L, Luo JM, Liu XJ, Wen SP, Du XY, Yao L
Ai Zheng. 2009
PubMed ID: 19622295
Akt regulates skeletal development through GSK3, mTOR, and FoxOs.
Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A, Komori T
Dev Biol. 2009
PubMed ID: 19389373
Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction.
Gnecchi M, He H, Melo LG, Noiseaux N, Morello F, de Boer RA, Zhang L, Pratt RE, Dzau VJ, Ingwall JS
Stem Cells. 2009
PubMed ID: 19353525
The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats.
Chen P, Yan H, Chen Y, He Z
Exp Mol Pathol. 2009
PubMed ID: 19348060
Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation.
Hsieh CH, Nickel EA, Chen J, Schwacha MG, Choudhry MA, Bland KI, Chaudry IH
J Immunol. 2009
PubMed ID: 19299741
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W
Nat Cell Biol. 2009
PubMed ID: 19270695
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP
Nat Cell Biol. 2009
PubMed ID: 19270694
Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways.
Lee MY, Lee SH, Park JH, Han HJ
Cell Mol Life Sci. 2009
PubMed ID: 19266163
Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.
Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB
Gastroenterology. 2009
PubMed ID: 19250983
Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal.
Bechard M, Dalton S
Mol Cell Biol. 2009
PubMed ID: 19223464
Gastrointestinal growth factors and hormones have divergent effects on Akt activation.
Berna MJ, Tapia JA, Sancho V, Thill M, Pace A, Hoffmann KM, Gonzalez-Fernandez L, Jensen RT
Cell Signal. 2009
PubMed ID: 19166928
Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes.
Berggreen C, Gormand A, Omar B, Degerman E, Göransson O
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19158325
Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex.
Cai QY, Chen XS, Zhong SC, Luo X, Yao ZX
Anat Rec (Hoboken). 2009
PubMed ID: 19142997
Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53.
Giustiniani J, Daire V, Cantaloube I, Durand G, Poüs C, Perdiz D, Baillet A
Cell Signal. 2009
PubMed ID: 19136058
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.
Chin YR, Toker A
Cell Signal. 2009
PubMed ID: 19110052
Role of protein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages.
Sun J, Ramnath RD, Tamizhselvi R, Bhatia M
FASEB J. 2009
PubMed ID: 19029199
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.
Brozzi F, Arcuri C, Giambanco I, Donato R
J Biol Chem. 2009
PubMed ID: 19147496
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer.
Trinh XB, Tjalma WA, Vermeulen PB, Van den Eynden G, Van der Auwera I, Van Laere SJ, Helleman J, Berns EM, Dirix LY, van Dam PA
Br J Cancer. 2009
PubMed ID: 19240722
beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1.
Green JA, Berrier AL, Pankov R, Yamada KM
J Biol Chem. 2009
PubMed ID: 19144637
Aberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomas.
Han S, Polizzano C, Nielsen GP, Hornicek FJ, Rosenberg AE, Ramesh V
Clin Cancer Res. 2009
PubMed ID: 19276265
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, Holland EC
Cell Stem Cell. 2009
PubMed ID: 19265662
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.
Park J, Feng J, Li Y, Hammarsten O, Brazil DP, Hemmings BA
J Biol Chem. 2009
PubMed ID: 19144640
E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3K-p85 regulatory subunit to adherens junctions of ovarian carcinoma cells.
De Santis G, Miotti S, Mazzi M, Canevari S, Tomassetti A
Oncogene. 2009
PubMed ID: 19151754
Akt/protein kinase B overexpression as an accurate prognostic marker in adult diffuse astrocytoma.
Matsutani T, Nagai Y, Mine S, Murai H, Saeki N, Iwadate Y
Acta Neurochir (Wien). 2009
PubMed ID: 19240976
Akt promotes BMP2-mediated osteoblast differentiation and bone development.
Mukherjee A, Rotwein P
J Cell Sci. 2009
PubMed ID: 19208758
ClipR-59 interacts with Akt and regulates Akt cellular compartmentalization.
Ding J, Du K
Mol Cell Biol. 2009
PubMed ID: 19139280
Antifolate/folate-activated HGF/c-Met signalling pathways in mouse kidneys-the putative role of their downstream effectors in cross-talk with androgen receptor.
Dudkowska M, Bajer S, Jaworski T, Zielińska J, Manteuffel-Cymborowska M, Grzelakowska-Sztabert B
Arch Biochem Biophys. 2009
PubMed ID: 19135973
TTP at Ser245 phosphorylation by AKT is required for binding to 14-3-3.
Chiba S, Tokuhara M, Morita EH, Abe S
J Biochem. 2009
PubMed ID: 19122209
Rac1 regulates peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway.
Chen BC, Kang JC, Lu YT, Hsu MJ, Liao CC, Chiu WT, Yeh FL, Lin CH
Mol Immunol. 2009
PubMed ID: 19118901
Cortical deficiency of laminin gamma1 impairs the AKT/GSK-3beta signaling pathway and leads to defects in neurite outgrowth and neuronal migration.
Chen ZL, Haegeli V, Yu H, Strickland S
Dev Biol. 2009
PubMed ID: 19118544
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M
Mol Cell Biol. 2009
PubMed ID: 19103742
Inhibition of spontaneous neutrophil apoptosis by parabutoporin acts independently of NADPH oxidase inhibition but by lipid raft-dependent stimulation of Akt.
Remijsen Q, Vanden Berghe T, Parthoens E, Asselbergh B, Vandenabeele P, Willems J
J Leukoc Biol. 2009
PubMed ID: 19095734
Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons.
Hwang JY, Duncan RS, Madry C, Singh M, Koulen P
Cell Calcium. 2009
PubMed ID: 19081133
CCL5 increases lung cancer migration via PI3K, Akt and NF-kappaB pathways.
Huang CY, Fong YC, Lee CY, Chen MY, Tsai HC, Hsu HC, Tang CH
Biochem Pharmacol. 2009
PubMed ID: 19073147
Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging.
Jackson TC, Rani A, Kumar A, Foster TC
Cell Death Differ. 2009
PubMed ID: 19039330
Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of pho
Adochio R, Leitner JW, Hedlund R, Draznin B
Endocrinology. 2009
PubMed ID: 18948408
Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice.
Goren I, Müller E, Schiefelbein D, Gutwein P, Seitz O, Pfeilschifter J, Frank S
J Invest Dermatol. 2009
PubMed ID: 18668138
Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.
Hildebrandt MA, Yang H, Hung MC, Izzo JG, Huang M, Lin J, Ajani JA, Wu X
J Clin Oncol. 2009
PubMed ID: 19164214
Phosphatidylinositol 3-kinase/AKT pathway regulates the endoplasmic reticulum to golgi traffic of ceramide in glioma cells: a link between lipid signaling pathways involved in the control of cell survival.
Giussani P, Brioschi L, Bassi R, Riboni L, Viani P
J Biol Chem. 2009
PubMed ID: 19103588
The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors.
Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M
J Biol Chem. 2009
PubMed ID: 19098000
Differential regulation of Akt/protein kinase B isoforms during cell cycle progression.
Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM, Lee SY, Yun J, Kim CD, Birnbaum MJ, Bae SS
FEBS Lett. 2009
PubMed ID: 19166849
Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium.
Beaver LM, Stemmy EJ, Constant SL, Schwartz A, Little LG, Gigley JP, Chun G, Sugden KD, Ceryak SM, Patierno SR
Toxicol Appl Pharmacol. 2009
PubMed ID: 19109987
Genetic association studies of methamphetamine use disorders: A systematic review and synthesis.
Bousman CA, Glatt SJ, Everall IP, Tsuang MT
Am J Med Genet B Neuropsychiatr Genet. 2009
PubMed ID: 19219857
Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.
Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A
J Biol Chem. 2009
PubMed ID: 19074768
Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition.
Lee JY, Kang MB, Jang SH, Qian T, Kim HJ, Kim CH, Kim Y, Kong G
Oncogene. 2009
PubMed ID: 19079342
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.
Kawase T, Ohki R, Shibata T, Tsutsumi S, Kamimura N, Inazawa J, Ohta T, Ichikawa H, Aburatani H, Tashiro F, Taya Y
Cell. 2009
PubMed ID: 19203586
The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.
Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR
J Biol Chem. 2009
PubMed ID: 19068483
Regulation of a third conserved phosphorylation site in SGK1.
Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH
J Biol Chem. 2009
PubMed ID: 19068477
Adenovirus 5 E1A is responsible for increased expression of insulin receptor substrate 4 in established adenovirus 5-transformed cell lines and interacts with IRS components activating the PI3 kinase/Akt signalling pathway.
Shimwell NJ, Martin A, Bruton RK, Blackford AN, Sedgwick GG, Gallimore PH, Turnell AS, Grand RJ
Oncogene. 2009
PubMed ID: 19029952
Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.
Bertoli C, Copetti T, Lam EW, Demarchi F, Schneider C
Oncogene. 2009
PubMed ID: 19029949
Correlation between PTEN expression and PI3K/Akt signal pathway in endometrial carcinoma.
Gao Q, Ye F, Xia X, Xing H, Lu Y, Zhou J, Ma D
J Huazhong Univ Sci Technolog Med Sci. 2009
PubMed ID: 19224164
Insulin enhances proliferation and viability of human umbilical vein endothelial cells.
Shrader CD, Bailey KM, Konat GW, Cilento EV, Reilly FD
Arch Dermatol Res. 2009
PubMed ID: 19115062
Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling.
Wang J, Zhao Y, Kauss MA, Spindel S, Lian H
Eur J Cell Biol. 2009
PubMed ID: 19058874
Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
Lee JH, Palaia T, Ragolia L
Am J Physiol Cell Physiol. 2009
PubMed ID: 19052261
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S
Clin Chim Acta. 2009
PubMed ID: 18996102
Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells.
Das T, Bae YH, Wells A, Roy P
J Cell Physiol. 2009
PubMed ID: 18937284
Follicle-stimulating hormone inhibits adenosine 5'-monophosphate-activated protein kinase activation and promotes cell proliferation of primary granulosa cells in culture through an Akt-dependent pathway.
Kayampilly PP, Menon KM
Endocrinology. 2009
PubMed ID: 18927218
Preimplantation embryo development in the mouse requires the latency of TRP53 expression, which is induced by a ligand-activated PI3 kinase/AKT/MDM2-mediated signaling pathway.
Jin XL, Chandrakanthan V, Morgan HD, O'Neill C
Biol Reprod. 2009
PubMed ID: 18923161
14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly.
Somanath PR, Byzova TV
J Cell Physiol. 2009
PubMed ID: 18853424
Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.
Cabodi S, Morello V, Masi A, Cicchi R, Broggio C, Distefano P, Brunelli E, Silengo L, Pavone F, Arcangeli A, Turco E, Tarone G, Moro L, Defilippi P
J Cell Physiol. 2009
PubMed ID: 18844239
PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.
García MG, Alaniz LD, Cordo Russo RI, Alvarez E, Hajos SE
Leuk Res. 2009
PubMed ID: 18640717
Expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine and alkaline stimulation.
Wu HT, Ko SY, Fong JH, Chang KW, Liu TY, Kao SY
J Oral Pathol Med. 2009
PubMed ID: 18331557
Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.
Gregório SP, Sallet PC, Do KA, Lin E, Gattaz WF, Dias-Neto E
Psychiatry Res. 2009
PubMed ID: 19054571
Adherens junction-dependent PI3K/Akt activation induces resistance to genotoxin-induced cell death in differentiated intestinal epithelial cells.
Chae B, Yang KM, Kim TI, Kim WH
Biochem Biophys Res Commun. 2009
PubMed ID: 19059380
Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.
Al-Salihi MA, Terrece Pearman A, Doan T, Reichert EC, Rosenberg DW, Prescott SM, Stafforini DM, Topham MK
Cancer Lett. 2009
PubMed ID: 18790560
Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production.
Herrera M, Hong NJ, Ortiz PA, Garvin JL
J Biol Chem. 2009
PubMed ID: 19033447
Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
Virtanen C, Paris J, Takahashi M
J Biol Chem. 2009
PubMed ID: 19028694
Helicobacter pylori VacA-induced inhibition of GSK3 through the PI3K/Akt signaling pathway.
Nakayama M, Hisatsune J, Yamasaki E, Isomoto H, Kurazono H, Hatakeyama M, Azuma T, Yamaoka Y, Yahiro K, Moss J, Hirayama T
J Biol Chem. 2009
PubMed ID: 18996844
The expression of phospho-AKT, phospho-mTOR, and PTEN in extrahepatic cholangiocarcinoma.
Chung JY, Hong SM, Choi BY, Cho H, Yu E, Hewitt SM
Clin Cancer Res. 2009
PubMed ID: 19147772
Integrin-linked kinase is required for vitronectin-mediated internalization of Streptococcus pneumoniae by host cells.
Bergmann S, Lang A, Rohde M, Agarwal V, Rennemeier C, Grashoff C, Preissner KT, Hammerschmidt S
J Cell Sci. 2009
PubMed ID: 19118218
Myogenic Akt signaling upregulates the utrophin-glycoprotein complex and promotes sarcolemma stability in muscular dystrophy.
Peter AK, Ko CY, Kim MH, Hsu N, Ouchi N, Rhie S, Izumiya Y, Zeng L, Walsh K, Crosbie RH
Hum Mol Genet. 2009
PubMed ID: 18986978
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK
J Cell Biol. 2009
PubMed ID: 19139267
Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.
Brenet F, Socci ND, Sonenberg N, Holland EC
Oncogene. 2009
PubMed ID: 18836485
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T
EMBO J. 2009
PubMed ID: 19057511
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells.
Yang XV, Banerjee Y, Fernández JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19116273
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations.
Dubrovska A, Kim S, Salamone RJ, Walker JR, Maira SM, García-Echeverría C, Schultz PG, Reddy VA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19116269
Age-related decrease in constructive activation of Akt/PKB in SAMP10 hippocampus.
Nie K, Yu JC, Fu Y, Cheng HY, Chen FY, Qu Y, Han JX
Biochem Biophys Res Commun. 2009
PubMed ID: 19013131
Altered regulation of contraction-induced Akt/mTOR/p70S6k pathway signaling in skeletal muscle of the obese Zucker rat.
Katta A, Kakarla S, Wu M, Paturi S, Gadde MK, Arvapalli R, Kolli M, Rice KM, Blough ER
Exp Diabetes Res. 2009
PubMed ID: 20368999
Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.
Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J
Mol Cancer. 2009
PubMed ID: 20042122
Controversies in breast cancer: the mammalian target of rapamycin as a target for breast cancer therapy.
Di Cosimo S
Breast Cancer Res. 2009
PubMed ID: 20030877
N-cadherin negatively regulates osteoblast proliferation and survival by antagonizing Wnt, ERK and PI3K/Akt signalling.
Haÿ E, Nouraud A, Marie PJ
PLoS One. 2009
PubMed ID: 20011526
Lewis y antigen promotes the proliferation of ovarian carcinoma-derived RMG-I cells through the PI3K/Akt signaling pathway.
Liu J, Lin B, Hao Y, Qi Y, Zhu L, Li F, Liu D, Cong J, Zhang S, Iwamori M
J Exp Clin Cancer Res. 2009
PubMed ID: 20003467
Inhibition of PI3K-Akt signaling blocks exercise-mediated enhancement of adult neurogenesis and synaptic plasticity in the dentate gyrus.
Bruel-Jungerman E, Veyrac A, Dufour F, Horwood J, Laroche S, Davis S
PLoS One. 2009
PubMed ID: 19936256
Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.
Rajaram MV, Butchar JP, Parsa KV, Cremer TJ, Amer A, Schlesinger LS, Tridandapani S
PLoS One. 2009
PubMed ID: 19936232
Rapid activation of Rac GTPase in living cells by force is independent of Src.
Poh YC, Na S, Chowdhury F, Ouyang M, Wang Y, Wang N
PLoS One. 2009
PubMed ID: 19924282
Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy.
Chuenkova MV, PereiraPerrin M
Sci Signal. 2009
PubMed ID: 19920252
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway.
Dong P, Xu Z, Jia N, Li D, Feng Y
Mol Cancer. 2009
PubMed ID: 19917135
Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.
Yao JE, Yan M, Guan Z, Pan CB, Xia LP, Li CX, Wang LH, Long ZJ, Zhao Y, Li MW, Zheng FM, Xu J, Lin DJ, Liu Q
Mol Cancer. 2009
PubMed ID: 19891769
Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression.
Antico Arciuch VG, Galli S, Franco MC, Lam PY, Cadenas E, Carreras MC, Poderoso JJ
PLoS One. 2009
PubMed ID: 19844585
MicroRNAs differentially regulated by Akt isoforms control EMT and stem cell renewal in cancer cells.
Iliopoulos D, Polytarchou C, Hatziapostolou M, Kottakis F, Maroulakou IG, Struhl K, Tsichlis PN
Sci Signal. 2009
PubMed ID: 19825827
A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells.
Lin SL, Yan LY, Liang XW, Wang ZB, Wang ZY, Qiao J, Schatten H, Sun QY
Reprod Biol Endocrinol. 2009
PubMed ID: 19775474
Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.
Uddin S, Bu R, Ahmed M, Abubaker J, Al-Dayel F, Bavi P, Al-Kuraya KS
Mol Cancer. 2009
PubMed ID: 19765303
Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation.
Biscetti F, Straface G, Arena V, Stigliano E, Pecorini G, Rizzo P, De Angelis G, Iuliano L, Ghirlanda G, Flex A
Cardiovasc Diabetol. 2009
PubMed ID: 19737384
Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic rats.
Huang JP, Huang SS, Deng JY, Hung LM
J Biomed Sci. 2009
PubMed ID: 19706162
The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.
Li SL, Huang ZN, Hsieh HH, Yu WC, Tzeng WY, Lee GY, Chen YP, Chang CY, Chuu JJ
Am J Chin Med. 2009
PubMed ID: 19655414
(-)-Epigallocatechin-3-gallate (EGCG) increases the viability of serum-starved A549 cells through its effect on Akt.
Kim MJ, Kim HI, Chung J, Jeong TS, Park HR
Am J Chin Med. 2009
PubMed ID: 19655410
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo.
Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC
Sci Signal. 2009
PubMed ID: 19654415
Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility.
Pecorari L, Marin O, Silvestri C, Candini O, Rossi E, Guerzoni C, Cattelani S, Mariani SA, Corradini F, Ferrari-Amorotti G, Cortesi L, Bussolari R, Raschellà G, Federico MR, Calabretta B
Mol Cancer. 2009
PubMed ID: 19646290
Integrin-linked kinase: a multi-functional regulator modulating extracellular pressure-stimulated cancer cell adhesion through focal adhesion kinase and AKT.
Wang S, Basson MD
Cell Oncol. 2009
PubMed ID: 19633364
Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.
Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD
PLoS One. 2009
PubMed ID: 19593385
Essential roles of mTOR/Akt pathway in Aurora-A cell transformation.
Taga M, Hirooka E, Ouchi T
Int J Biol Sci. 2009
PubMed ID: 19564927
Interactions between glycogen synthase kinase 3beta, protein kinase B, and protein phosphatase 2A in tau phosphorylation in mouse N2a neuroblastoma cells.
Zhou XW, Winblad B, Guan Z, Pei JJ
J Alzheimers Dis. 2009
PubMed ID: 19542610
Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
Melnick M, Phair RD, Lapidot SA, Jaskoll T
BMC Dev Biol. 2009
PubMed ID: 19500387
[Activation and clinicopathologic significance of AKT/mTOR signaling pathway in diffuse large B-cell lymphoma].
Yu BH, Zhou XY, Xiao XY, Yan SY, Qin T, Shi DR
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 19489223
Absence of AKT1 mutations in glioblastoma.
Bleeker FE, Lamba S, Zanon C, van Tilborg AA, Leenstra S, Troost D, Hulsebos T, Vandertop WP, Bardelli A
PLoS One. 2009
PubMed ID: 19461960
Human neural stem cells genetically modified to overexpress Akt1 provide neuroprotection and functional improvement in mouse stroke model.
Lee HJ, Kim MK, Kim HJ, Kim SU
PLoS One. 2009
PubMed ID: 19440551
QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outc
Kalra J, Warburton C, Fang K, Edwards L, Daynard T, Waterhouse D, Dragowska W, Sutherland BW, Dedhar S, Gelmon K, Bally M
Breast Cancer Res. 2009
PubMed ID: 19409087
Structure-Function analysis of the CTLA-4 interaction with PP2A.
Teft WA, Chau TA, Madrenas J
BMC Immunol. 2009
PubMed ID: 19405949
Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas.
Eom HS, Kim MS, Hur SY, Yoo NJ, Lee SH
Acta Oncol. 2009
PubMed ID: 19353338
Expression of p-Akt in sensory neurons and spinal cord after peripheral nerve injury.
Shi TJ, Huang P, Mulder J, Ceccatelli S, Hokfelt T
Neurosignals. 2009
PubMed ID: 19346757
Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins.
Castelló-Cros R, Khan DR, Simons J, Valianou M, Cukierman E
BMC Cancer. 2009
PubMed ID: 19323811
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR.
Wang CY, Kim HH, Hiroi Y, Sawada N, Salomone S, Benjamin LE, Walsh K, Moskowitz MA, Liao JK
Sci Signal. 2009
PubMed ID: 19293429
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH
Neural Dev. 2009
PubMed ID: 19291307
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.
Lodeiro M, Theodoropoulou M, Pardo M, Casanueva FF, Camiña JP
PLoS One. 2009
PubMed ID: 19262695
beta-arrestin2 inhibits opioid-induced breast cancer cell death through Akt and caspase-8 pathways.
Zhao M, Zhou G, Zhang Y, Chen T, Sun X, Stuart C, Hanley G, Li J, Zhang J, Yin D
Neoplasma. 2009
PubMed ID: 19239323
1,25-Dihydroxyvitamin D(3) prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the phosphatidylinositol 3-kinase/Akt-signaling pathway.
Xiao H, Shi W, Liu S, Wang W, Zhang B, Zhang Y, Xu L, Liang X, Liang Y
Am J Nephrol. 2009
PubMed ID: 19202327
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA
Sci Signal. 2009
PubMed ID: 19176518
The PtdIns 3-kinase/Akt pathway regulates macrophage-mediated ADCC against B cell lymphoma.
Joshi T, Ganesan LP, Cheney C, Ostrowski MC, Muthusamy N, Byrd JC, Tridandapani S
PLoS One. 2009
PubMed ID: 19148288
KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells.
Choi UJ, Jee BK, Lim Y, Lee KH
Cell Biochem Funct. 2009
PubMed ID: 19107873
Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression.
Flacke JP, Kumar S, Kostin S, Reusch HP, Ladilov Y
Apoptosis. 2009
PubMed ID: 19082728
Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt.
Zhang CM, Chen XH, Wang B, Liu F, Chi X, Tong ML, Ni YH, Chen RH, Guo XR
Acta Pharmacol Sin. 2009
PubMed ID: 19079291
The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation.
Haga S, Ozaki M, Inoue H, Okamoto Y, Ogawa W, Takeda K, Akira S, Todo S
Hepatology. 2009
PubMed ID: 19065678
Sustained activation of Akt and Erk1/2 is required for Coxiella burnetii antiapoptotic activity.
Voth DE, Heinzen RA
Infect Immun. 2009
PubMed ID: 18981248
Prevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers.
Kovacs K, Hanto K, Bognar Z, Tapodi A, Bognar E, Kiss GN, Szabo A, Rappai G, Kiss T, Sumegi B, Gallyas F
Mol Cell Biochem. 2009
PubMed ID: 18975057
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.
Chabot C, Spring K, Gratton JP, Elchebly M, Royal I
Mol Cell Biol. 2009
PubMed ID: 18936167
NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway.
Stewart GD, Nanda J, Brown DJ, Riddick AC, Ross JA, Habib FK
Int J Cancer. 2009
PubMed ID: 18924134
Role of RHOB in the antiproliferative effect of glucocorticoid receptor on macrophage RAW264.7 cells.
Wang X, Chen Y, Wang Y, Zhu X, Ma Y, Zhang S, Lu J
J Endocrinol. 2009
PubMed ID: 18840672
Helicobacter pylori activate epidermal growth factor receptor- and phosphatidylinositol 3-OH kinase-dependent Akt and glycogen synthase kinase 3beta phosphorylation.
Tabassam FH, Graham DY, Yamaoka Y
Cell Microbiol. 2009
PubMed ID: 18782353
Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.
Vejux A, Guyot S, Montange T, Riedinger JM, Kahn E, Lizard G
J Nutr Biochem. 2009
PubMed ID: 18495460
Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype.
Tsika RW, Schramm C, Simmer G, Fitzsimons DP, Moss RL, Ji J
J Biol Chem. 2008
PubMed ID: 18978355
Akt activation prevents Apop-1-induced death of cells.
Sun X, Yasuda O, Takemura Y, Kawamoto H, Higuchi M, Baba Y, Katsuya T, Fukuo K, Ogihara T, Rakugi H
Biochem Biophys Res Commun. 2008
PubMed ID: 18977203
MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway.
Ren K, Jin H, Bian C, He H, Liu X, Zhang S, Wang Y, Shao RG
J Biol Chem. 2008
PubMed ID: 18948272
Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection.
Del Re DP, Miyamoto S, Brown JH
J Biol Chem. 2008
PubMed ID: 18854312
Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells.
Ogunwobi OO, Beales IL
Mol Cell Endocrinol. 2008
PubMed ID: 18771702
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells.
Lin HJ, Zuo T, Lin CH, Kuo CT, Liyanarachchi S, Sun S, Shen R, Deatherage DE, Potter D, Asamoto L, Lin S, Yan PS, Cheng AL, Ostrowski MC, Huang TH
Cancer Res. 2008
PubMed ID: 19074894
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
Negative Regulation of AKT Activation by BRCA1.
Xiang T, Ohashi A, Huang Y, Pandita TK, Ludwig T, Powell SN, Yang Q
Cancer Res. 2008
PubMed ID: 19074868
Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway.
Chen PH, Yang CR
J Immunol. 2008
PubMed ID: 19050262
TLR9-activating DNA up-regulates ZAP70 via sustained PKB induction in IgM+ B cells.
Bekeredjian-Ding I, Doster A, Schiller M, Heyder P, Lorenz HM, Schraven B, Bommhardt U, Heeg K
J Immunol. 2008
PubMed ID: 19050243
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis.
Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N
Cancer Cell. 2008
PubMed ID: 19061837
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.
Fu Y, Wey S, Wang M, Ye R, Liao CP, Roy-Burman P, Lee AS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19033462
Association of AKT1 with verbal learning, verbal memory, and regional cortical gray matter density in twins.
Pietiläinen OP, Paunio T, Loukola A, Tuulio-Henriksson A, Kieseppä T, Thompson P, Toga AW, van Erp TG, Silventoinen K, Soronen P, Hennah W, Turunen JA, Wedenoja J, Palo OM, Silander K, Lönnqvist J, Kaprio J, Cannon TD, Peltonen L
Am J Med Genet B Neuropsychiatr Genet. 2008
PubMed ID: 19051289
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
Platonin inhibits LPS-induced NF-kappaB by preventing activation of Akt and IKKbeta in human PBMC.
Shao DZ, Lin M
Inflamm Res. 2008
PubMed ID: 19109741
c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation.
Kim MJ, Byun JY, Yun CH, Park IC, Lee KH, Lee SJ
Mol Cancer Res. 2008
PubMed ID: 19074832
Increased staining for phosphorylated AKT and nuclear factor-kappaB p65 and their relationship with prognosis in epithelial ovarian cancer.
Guo RX, Qiao YH, Zhou Y, Li LX, Shi HR, Chen KS
Pathol Int. 2008
PubMed ID: 19067848
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Insulin-like growth factor binding protein 7 mediates glioma cell growth and migration.
Jiang W, Xiang C, Cazacu S, Brodie C, Mikkelsen T
Neoplasia. 2008
PubMed ID: 19048112
Effects of Akt signaling on nuclear reprogramming.
Nakamura T, Inoue K, Ogawa S, Umehara H, Ogonuki N, Miki H, Kimura T, Ogura A, Nakano T
Genes Cells. 2008
PubMed ID: 19032345
Glioma cells enhance endothelial progenitor cell angiogenesis via VEGFR-2, not VEGFR-1.
Zhang J, Zhao P, Fu Z, Chen X, Liu N, Lu A, Li R, Shi L, Pu P, Kang C, You Y
Oncol Rep. 2008
PubMed ID: 19020728
ILK overexpression in human hepatocellular carcinoma and liver cirrhosis correlates with activation of Akt.
Peroukides S, Bravou V, Varakis J, Alexopoulos A, Kalofonos H, Papadaki H
Oncol Rep. 2008
PubMed ID: 19020711
CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo.
Dormond O, Contreras AG, Meijer E, Datta D, Flynn E, Pal S, Briscoe DM
J Immunol. 2008
PubMed ID: 19018001
RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.
Bansal G, DiVietro JA, Kuehn HS, Rao S, Nocka KH, Gilfillan AM, Druey KM
J Immunol. 2008
PubMed ID: 19017978
Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation.
Oh JH, Lee TJ, Kim SH, Choi YH, Lee SH, Lee JM, Kim YH, Park JW, Kwon TK
Apoptosis. 2008
PubMed ID: 19002588
Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes.
Peterson JM, Wang Y, Bryner RW, Williamson DL, Alway SE
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18840766
Calreticulin regulates insulin receptor expression and its downstream PI3 Kinase/Akt signalling pathway.
Jalali S, Aghasi M, Yeganeh B, Mesaeli N
Biochim Biophys Acta. 2008
PubMed ID: 18840478
o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.
Han EH, Kim JY, Kim HK, Hwang YP, Jeong HG
Toxicol Appl Pharmacol. 2008
PubMed ID: 18840457
AKT alters genome-wide estrogen receptor alpha binding and impacts estrogen signaling in breast cancer.
Bhat-Nakshatri P, Wang G, Appaiah H, Luktuke N, Carroll JS, Geistlinger TR, Brown M, Badve S, Liu Y, Nakshatri H
Mol Cell Biol. 2008
PubMed ID: 18838536
Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways.
Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, Yu Y, Cao X
Mol Immunol. 2008
PubMed ID: 18838169
NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.
Kang MJ, Ryu BK, Lee MG, Han J, Lee JH, Ha TK, Byun DS, Chae KS, Lee BH, Chun HS, Lee KY, Kim HJ, Chi SG
Gastroenterology. 2008
PubMed ID: 18824170
Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositides.
Li G, Rajala A, Wiechmann AF, Anderson RE, Rajala RV
J Neurochem. 2008
PubMed ID: 18823366
Brain cancer stem cells display preferential sensitivity to Akt inhibition.
Eyler CE, Foo WC, LaFiura KM, McLendon RE, Hjelmeland AB, Rich JN
Stem Cells. 2008
PubMed ID: 18802038
An activating mutation in AKT1 in human prostate cancer.
Boormans JL, Hermans KG, van Leenders GJ, Trapman J, Verhagen PC
Int J Cancer. 2008
PubMed ID: 18798258
Age-related changes of calcineurin and Akt1/protein kinase Balpha (Akt1/PKBalpha) immunoreactivity in the mouse hippocampal CA1 sector: an immunohistochemical study.
Eto R, Abe M, Hayakawa N, Kato H, Araki T
Metab Brain Dis. 2008
PubMed ID: 18770014
Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis.
Rogers R, Ouellet G, Brown C, Moyer B, Rasoulpour T, Hixon M
Toxicol Sci. 2008
PubMed ID: 18755736
Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle.
Blaauw B, Mammucari C, Toniolo L, Agatea L, Abraham R, Sandri M, Reggiani C, Schiaffino S
Hum Mol Genet. 2008
PubMed ID: 18753145
BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway.
Fong YC, Li TM, Wu CM, Hsu SF, Kao ST, Chen RJ, Lin CC, Liu SC, Wu CL, Tang CH
J Cell Physiol. 2008
PubMed ID: 18720410
Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3beta pathway.
Yao YY, Yin H, Shen B, Smith RS, Liu Y, Gao L, Chao L, Chao J
Cardiovasc Res. 2008
PubMed ID: 18689794
Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.
Sugawara T, Ayer R, Jadhav V, Chen W, Tsubokawa T, Zhang JH
J Neurosci Res. 2008
PubMed ID: 18683242
TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways.
Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F
J Cell Physiol. 2008
PubMed ID: 18668519
Enhanced survival of melanopsin-expressing retinal ganglion cells after injury is associated with the PI3 K/Akt pathway.
Li SY, Yau SY, Chen BY, Tay DK, Lee VW, Pu ML, Chan HH, So KF
Cell Mol Neurobiol. 2008
PubMed ID: 18512147
Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain.
Guedes RP, Araújo AS, Janner D, Belló-Klein A, Ribeiro MF, Partata WA
Cell Mol Neurobiol. 2008
PubMed ID: 18379870
Induction of Mac-2BP by nerve growth factor is regulated by the PI3K/Akt/NF-kappaB-dependent pathway in the HEK293 cell line.
Park YP, Choi SC, Kim BY, Kim JT, Song EY, Kang SH, Yoon DY, Paik SG, Kim KD, Kim JW, Lee HG
BMB Rep. 2008
PubMed ID: 19017490
Cl- -channel is essential for LDL-induced cell proliferation via the activation of Erk1/2 and PI3k/Akt and the upregulation of Egr-1 in human aortic smooth muscle cells.
Heo KS, Ryoo SW, Kim L, Nam M, Baek ST, Lee H, Lee AR, Park SK, Park Y, Myung CS, Kim DU, Hoe KL
Mol Cells. 2008
PubMed ID: 18711316
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK
J Biol Chem. 2008
PubMed ID: 18838385
Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival.
Wang Y, Mikhailova M, Bose S, Pan CX, deVere White RW, Ghosh PM
Oncogene. 2008
PubMed ID: 18776922
Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.
Landgraf KE, Pilling C, Falke JJ
Biochemistry. 2008
PubMed ID: 18954143
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
Fan GC, Zhou X, Wang X, Song G, Qian J, Nicolaou P, Chen G, Ren X, Kranias EG
Circ Res. 2008
PubMed ID: 18948619
Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
Piantadosi CA, Carraway MS, Babiker A, Suliman HB
Circ Res. 2008
PubMed ID: 18845810
Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism.
Ouchi N, Oshima Y, Ohashi K, Higuchi A, Ikegami C, Izumiya Y, Walsh K
J Biol Chem. 2008
PubMed ID: 18718903
Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.
Zhu S, Evans S, Yan B, Povsic TJ, Tapson V, Goldschmidt-Clermont PJ, Dong C
Circulation. 2008
PubMed ID: 18981303
Increased vascular senescence and impaired endothelial progenitor cell function mediated by mutation of circadian gene Per2.
Wang CY, Wen MS, Wang HW, Hsieh IC, Li Y, Liu PY, Lin FC, Liao JK
Circulation. 2008
PubMed ID: 18981300
AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51.
Plo I, Laulier C, Gauthier L, Lebrun F, Calvo F, Lopez BS
Cancer Res. 2008
PubMed ID: 19010915
FGF21 is an Akt-regulated myokine.
Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K
FEBS Lett. 2008
PubMed ID: 18948104
Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway.
Liu HY, Wen GB, Han J, Hong T, Zhuo D, Liu Z, Cao W
J Biol Chem. 2008
PubMed ID: 18786922
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells.
Shi X, Burkart A, Nicoloro SM, Czech MP, Straubhaar J, Corvera S
J Biol Chem. 2008
PubMed ID: 18779333
The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint.
Xue L, Chiang L, Kang C, Winoto A
Eur J Immunol. 2008
PubMed ID: 18991293
Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment.
Jinushi M, Nakazaki Y, Carrasco DR, Draganov D, Souders N, Johnson M, Mihm MC, Dranoff G
Cancer Res. 2008
PubMed ID: 18974133
Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk.
Mori K, Blanchard F, Charrier C, Battaglia S, Ando K, Duplomb L, Shultz LD, Redini F, Heymann D
Cancer Sci. 2008
PubMed ID: 18957057
Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.
Kawahara K, Hashiguchi T, Kikuchi K, Tancharoen S, Miura N, Ito T, Oyama Y, Nawa Y, Biswas KK, Meng X, Morimoto Y, Shrestha B, Sameshima H, Maruyama I
Int J Mol Med. 2008
PubMed ID: 18949384
Activated Akt as an indicator of prognosis in gastric cancer.
Cinti C, Vindigni C, Zamparelli A, La Sala D, Epistolato MC, Marrelli D, Cevenini G, Tosi P
Virchows Arch. 2008
PubMed ID: 18841391
Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.
Nagaike K, Kawaguchi M, Takeda N, Fukushima T, Sawaguchi A, Kohama K, Setoyama M, Kataoka H
Am J Pathol. 2008
PubMed ID: 18832587
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.
Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F
Development. 2008
PubMed ID: 18832393
Integrin-linked kinase cytoplasmic and nuclear expression in laryngeal carcinomas.
Goulioumis AK, Bravou V, Varakis J, Goumas P, Papadaki H
Virchows Arch. 2008
PubMed ID: 18813944
The early phase of programmed cell death in Caco-2 intestinal cells exposed to PTH.
Calvo NG, Gentili CR, de Boland AR
J Cell Biochem. 2008
PubMed ID: 18798227
Lesion-targeted thrombopoietin potentiates vasculogenesis by enhancing motility and enlivenment of transplanted endothelial progenitor cells via activation of Akt/mTOR/p70S6kinase signaling pathway.
Eguchi M, Masuda H, Kwon S, Shirakura K, Shizuno T, Ito R, Kobori M, Asahara T
J Mol Cell Cardiol. 2008
PubMed ID: 18773906
Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells.
Kim S, Lee TJ, Park JW, Kwon TK
J Cell Biochem. 2008
PubMed ID: 18767116
AKT1-dependent activation of NF-kappaB by the L protein of parainfluenza virus 5.
Luthra P, Sun D, Wolfgang M, He B
J Virol. 2008
PubMed ID: 18715928
Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria.
Chen HZ, Zhao BX, Zhao WX, Li L, Zhang B, Wu Q
Carcinogenesis. 2008
PubMed ID: 18713840
Linker region of Akt1/protein kinase Balpha mediates platelet-derived growth factor-induced translocation and cell migration.
Kim EK, Tucker DF, Yun SJ, Do KH, Kim MS, Kim JH, Kim CD, Birnbaum MJ, Bae SS
Cell Signal. 2008
PubMed ID: 18700164
Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency.
Hu J, Klein JD, Du J, Wang XH
Endocrinology. 2008
PubMed ID: 18653708
Ankyrin repeat and suppressor of cytokine signaling (SOCS) box-containing protein (ASB) 15 alters differentiation of mouse C2C12 myoblasts and phosphorylation of mitogen-activated protein kinase and Akt.
McDaneld TG, Spurlock DM
J Anim Sci. 2008
PubMed ID: 18641171
Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells.
Li M, Chiu JF, Gagne J, Fukagawa NK
J Cell Physiol. 2008
PubMed ID: 18615585
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution.
Maroulakou IG, Oemler W, Naber SP, Klebba I, Kuperwasser C, Tsichlis PN
J Cell Physiol. 2008
PubMed ID: 18561256
Lack of cytoplasmic ERK activation is an independent adverse prognostic factor in primary cutaneous melanoma.
Jovanovic B, Kröckel D, Linden D, Nilsson B, Egyhazi S, Hansson J
J Invest Dermatol. 2008
PubMed ID: 18509361
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.
Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA
J Biol Chem. 2008
PubMed ID: 18757368
rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain.
Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P, Bunney TD
J Biol Chem. 2008
PubMed ID: 18728011
Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli.
Marchi S, Rimessi A, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P
Biochem Biophys Res Commun. 2008
PubMed ID: 18723000
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival.
Lee SB, Xuan Nguyen TL, Choi JW, Lee KH, Cho SW, Liu Z, Ye K, Bae SS, Ahn JY
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18931307
PI3K/Akt: getting it right matters.
Franke TF
Oncogene. 2008
PubMed ID: 18955974
Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.
Castro-Rivera E, Ran S, Brekken RA, Minna JD
Cancer Res. 2008
PubMed ID: 18922901
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli.
Krishnan V, Han MH, Mazei-Robison M, Iñiguez SD, Ables JL, Vialou V, Berton O, Ghose S, Covington HE, Wiley MD, Henderson RP, Neve RL, Eisch AJ, Tamminga CA, Russo SJ, Bolaños CA, Nestler EJ
Biol Psychiatry. 2008
PubMed ID: 18639865
Combined functional and molecular analysis of tumor cell signaling defines 2 distinct myeloma subgroups: Akt-dependent and Akt-independent multiple myeloma.
Zöllinger A, Stühmer T, Chatterjee M, Gattenlöhner S, Haralambieva E, Müller-Hermelink HK, Andrulis M, Greiner A, Wesemeier C, Rath JC, Einsele H, Bargou RC
Blood. 2008
PubMed ID: 18635812
Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells.
Partovian C, Ju R, Zhuang ZW, Martin KA, Simons M
Mol Cell. 2008
PubMed ID: 18851840
Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1.
Snabaitis AK, Cuello F, Avkiran M
Circ Res. 2008
PubMed ID: 18757828
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit.
Sun J, Pedersen M, Rönnstrand L
J Biol Chem. 2008
PubMed ID: 18697750
Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells.
Li Y, Wang Z, Kong D, Li R, Sarkar SH, Sarkar FH
J Biol Chem. 2008
PubMed ID: 18687691
Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia.
Zai CC, Romano-Silva MA, Hwang R, Zai GC, Deluca V, Müller DJ, King N, Voineskos AN, Meltzer HY, Lieberman JA, Potkin SG, Remington G, Kennedy JL
Schizophr Res. 2008
PubMed ID: 18838251
Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme.
Chen CA, Druhan LJ, Varadharaj S, Chen YR, Zweier JL
J Biol Chem. 2008
PubMed ID: 18622039
[Study on activation of AKT/mTOR pathway in anaplastic large cell lymphoma]
Li JF, Li GD, Gu L, Liu WP, Li FY, Liao DY, Ma ZG
Zhonghua Xue Ye Xue Za Zhi. 2008
PubMed ID: 19176054
A pilot surrogate endpoint biomarker study of celecoxib in oral premalignant lesions.
Wirth LJ, Krane JF, Li Y, Othus M, Moran AE, Dorfman DM, Norris CM, Goguen L, Posner MR, Haddad RI, Bertagnolli MM
Cancer Prev Res (Phila Pa). 2008
PubMed ID: 19138978
Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients.
Li Y, Tanaka Y, Tada M, Hua R, Seto M, Asaoka Y, Ohta M, Kanai F, Yoshida H, Kawabe T, Sano T, Motojima T, Yokosuka O, Omata M
APMIS. 2008
PubMed ID: 19132987
Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.
Ikeda M, Yamanouchi Y, Kinoshita Y, Kitajima T, Yoshimura R, Hashimoto S, O'Donovan MC, Nakamura J, Ozaki N, Iwata N
Pharmacogenomics. 2008
PubMed ID: 18855532
Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.
Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES, Wang MB
Clin Cancer Res. 2008
PubMed ID: 18829502
Activation of Akt-mTOR-p70S6K pathway in angiogenesis in hepatocellular carcinoma.
Li W, Tan D, Zhang Z, Liang JJ, Brown RE
Oncol Rep. 2008
PubMed ID: 18813808
Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway.
Rømer MU, Larsen L, Offenberg H, Brünner N, Lademann UA
Neoplasia. 2008
PubMed ID: 18813358
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
AKT1 (E17K) mutation in pancreatic cancer.
Mohamedali A, Lea NC, Feakins RM, Raj K, Mufti GJ, Kocher HM
Technol Cancer Res Treat. 2008
PubMed ID: 18783292
c-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt.
Miyazaki T, Bub JD, Iwamoto Y
Biochim Biophys Acta. 2008
PubMed ID: 18718531
G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction.
García-Regalado A, Guzmán-Hernández ML, Ramírez-Rangel I, Robles-Molina E, Balla T, Vázquez-Prado J, Reyes-Cruz G
Mol Biol Cell. 2008
PubMed ID: 18701709
Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains.
Gao X, Zhang J
Mol Biol Cell. 2008
PubMed ID: 18701703
Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers.
Uddin S, Siraj AK, Al-Rasheed M, Ahmed M, Bu R, Myers JN, Al-Nuaim A, Al-Sobhi S, Al-Dayel F, Bavi P, Hussain AR, Al-Kuraya KS
J Clin Endocrinol Metab. 2008
PubMed ID: 18682509
PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.
Toulany M, Dittmann K, Fehrenbacher B, Schaller M, Baumann M, Rodemann HP
DNA Repair (Amst). 2008
PubMed ID: 18678286
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids.
Birukova AA, Alekseeva E, Cokic I, Turner CE, Birukov KG
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18676874
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression.
Castino R, Thepparit C, Bellio N, Murphy D, Isidoro C
J Neuroendocrinol. 2008
PubMed ID: 18673414
Renal activity of Akt kinase in obese Zucker rats.
Zdychová J, Kazdová L, Pelikanová T, Lindsley JN, Anderson S, Komers R
Exp Biol Med (Maywood). 2008
PubMed ID: 18641049
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain.
An J, Zhang C, Polavarapu R, Zhang X, Zhang X, Yepes M
Blood. 2008
PubMed ID: 18628488
Modulation of caveolin-1 expression can affect signalling through the phosphatidylinositol 3-kinase/Akt pathway and cellular proliferation in response to insulin-like growth factor I.
Matthews LC, Taggart MJ, Westwood M
Endocrinology. 2008
PubMed ID: 18583416
Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.
Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL
Cell Signal. 2008
PubMed ID: 18565730
Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels.
Hsu JT, Kan WH, Hsieh YC, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
Shock. 2008
PubMed ID: 18277950
AKT1(E17K) in human solid tumours.
Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, Scarpa A, Leenstra S, Frattini M, Barbareschi M, Grammastro MD, Sciarrotta MG, Zanon C, Marchetti A, Bardelli A
Oncogene. 2008
PubMed ID: 18504432
LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.
Zhong D, Liu X, Khuri FR, Sun SY, Vertino PM, Zhou W
Cancer Res. 2008
PubMed ID: 18794113
GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma.
Dal Col J, Dolcetti R
Cell Cycle. 2008
PubMed ID: 18769147
Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK.
Hu Z, Chen J, Wei Q, Xia Y
J Biol Chem. 2008
PubMed ID: 18617528
Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.
Spencer JL, Waters EM, Milner TA, McEwen BS
Neuroscience. 2008
PubMed ID: 18601981
IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop.
Ren H, Yin P, Duan C
J Cell Biol. 2008
PubMed ID: 18762576
Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis.
Wang Y, Jiang XY, Liu L, Jiang HQ
World J Gastroenterol. 2008
PubMed ID: 18777595
CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation.
Roca H, Varsos Z, Pienta KJ
J Biol Chem. 2008
PubMed ID: 18611860
High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function.
Argraves KM, Gazzolo PJ, Groh EM, Wilkerson BA, Matsuura BS, Twal WO, Hammad SM, Argraves WS
J Biol Chem. 2008
PubMed ID: 18606817
The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling.
Chekenya M, Krakstad C, Svendsen A, Netland IA, Staalesen V, Tysnes BB, Selheim F, Wang J, Sakariassen PØ, Sandal T, Lønning PE, Flatmark T, Enger PØ, Bjerkvig R, Sioud M, Stallcup WB
Oncogene. 2008
PubMed ID: 18469852
Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway.
Han JK, Lee HS, Yang HM, Hur J, Jun SI, Kim JY, Cho CH, Koh GY, Peters JM, Park KW, Cho HJ, Lee HY, Kang HJ, Oh BH, Park YB, Kim HS
Circulation. 2008
PubMed ID: 18711014
Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas.
Scheper MA, Chaisuparat R, Nikitakis NG, Sauk JJ
Oral Dis. 2008
PubMed ID: 18826385
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.
Wang SE, Xiang B, Guix M, Olivares MG, Parker J, Chung CH, Pandiella A, Arteaga CL
Mol Cell Biol. 2008
PubMed ID: 18625725
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death.
Rojo AI, Rada P, Egea J, Rosa AO, López MG, Cuadrado A
Mol Cell Neurosci. 2008
PubMed ID: 18619545
Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins.
Lai TH, Fong YC, Fu WM, Yang RS, Tang CH
Prostate. 2008
PubMed ID: 18512729
Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha.
Kanichai M, Ferguson D, Prendergast PJ, Campbell VA
J Cell Physiol. 2008
PubMed ID: 18366089
Interleukin-3 (IL-3)-induced c-fos activation is modulated by Gab2-calcineurin interaction.
Pyarajan S, Matejovic G, Pratt JC, Baksh S, Burakoff SJ
J Biol Chem. 2008
PubMed ID: 18586679
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR
J Biol Chem. 2008
PubMed ID: 18562309
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18713867
Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling.
Jo OD, Martin J, Bernath A, Masri J, Lichtenstein A, Gera J
J Biol Chem. 2008
PubMed ID: 18562319
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
Joshi J, Fernandez-Marcos PJ, Galvez A, Amanchy R, Linares JF, Duran A, Pathrose P, Leitges M, Cañamero M, Collado M, Salas C, Serrano M, Moscat J, Diaz-Meco MT
EMBO J. 2008
PubMed ID: 18650932
The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by phosphatidylinositol 3-kinase/Akt intracellular signaling pathway.
Di Serio C, Doria L, Pellerito S, Prudovsky I, Micucci I, Massi D, Landriscina M, Marchionni N, Masotti G, Tarantini F
Cancer Lett. 2008
PubMed ID: 18400376
Suppression of c-Cbl tyrosine phosphorylation inhibits neointimal formation in balloon-injured rat arteries.
Tang Z, Wang Y, Fan Y, Zhu Y, Chien S, Wang N
Circulation. 2008
PubMed ID: 18663086
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias.
Mahmoud IS, Sughayer MA, Mohammad HA, Awidi AS, EL-Khateeb MS, Ismail SI
Br J Cancer. 2008
PubMed ID: 18665177
[The changes of PTEN/Akt1 expression and cell proliferation in pulmonary arterial smooth muscle cells induced by hypoxia in rats].
Yi B, Qian GS, Bai L
Zhonghua Jie He He Hu Xi Za Zhi. 2008
PubMed ID: 19080402
Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways.
Choi SC, Kim SJ, Choi JH, Park CY, Shim WJ, Lim DS
Stem Cells Dev. 2008
PubMed ID: 18788932
PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation.
Kita K, Kimura T, Nakamura N, Yoshikawa H, Nakano T
Genes Cells. 2008
PubMed ID: 18782222
Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction.
Li Q, Ceylan-Isik AF, Li J, Ren J
Rejuvenation Res. 2008
PubMed ID: 18729805
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Bernards R, Mills GB, Hennessy BT
Cancer Res. 2008
PubMed ID: 18676830
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.
Taddei A, Giampietro C, Conti A, Orsenigo F, Breviario F, Pirazzoli V, Potente M, Daly C, Dimmeler S, Dejana E
Nat Cell Biol. 2008
PubMed ID: 18604199
Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.
Nishi J, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I
Circ Res. 2008
PubMed ID: 18583712
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.
Yung HW, Calabrese S, Hynx D, Hemmings BA, Cetin I, Charnock-Jones DS, Burton GJ
Am J Pathol. 2008
PubMed ID: 18583310
Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells.
Chen YR, Liu MT, Chang YT, Wu CC, Hu CY, Chen JY
J Virol. 2008
PubMed ID: 18524825
JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells.
Jin H, Lanning NJ, Carter-Su C
Mol Endocrinol. 2008
PubMed ID: 18499741
Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.
LaMarca HL, Dash PR, Vishnuthevan K, Harvey E, Sullivan DE, Morris CA, Whitley GS
Hum Reprod. 2008
PubMed ID: 18487214
Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats.
Schakman O, Kalista S, Bertrand L, Lause P, Verniers J, Ketelslegers JM, Thissen JP
Endocrinology. 2008
PubMed ID: 18467435
The role of activin A and Akt/GSK signaling in ovarian tumor biology.
Do TV, Kubba LA, Antenos M, Rademaker AW, Sturgis CD, Woodruff TK
Endocrinology. 2008
PubMed ID: 18450971
Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation.
Xu X, Jhun BS, Ha CH, Jin ZG
Endocrinology. 2008
PubMed ID: 18450953
Vitamin D receptor-dependent 1 alpha,25(OH)2 vitamin D3-induced anti-apoptotic PI3K/AKT signaling in osteoblasts.
Zhang X, Zanello LP
J Bone Miner Res. 2008
PubMed ID: 18410228
Elevated phosphatidylinositol 3-kinase activation and its clinicopathological significance in cervical cancer.
Zhang XY, Zhang HY, Zhang PN, Lu X, Sun H
Eur J Obstet Gynecol Reprod Biol. 2008
PubMed ID: 18395956
Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts.
Bujor AM, Pannu J, Bu S, Smith EA, Muise-Helmericks RC, Trojanowska M
J Invest Dermatol. 2008
PubMed ID: 18323784
TNF-alpha impairs the S-G2/M cell cycle checkpoint and cyclobutane pyrimidine dimer repair in premalignant skin cells: role of the PI3K-Akt pathway.
Faurschou A, Gniadecki R, Calay D, Wulf HC
J Invest Dermatol. 2008
PubMed ID: 18273051
Modulation of the activities of AMP-activated protein kinase, protein kinase B, and mammalian target of rapamycin by limiting energy availability with 2-deoxyglucose.
Jiang W, Zhu Z, Thompson HJ
Mol Carcinog. 2008
PubMed ID: 18247380
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
Le Romancer M, Treilleux I, Leconte N, Robin-Lespinasse Y, Sentis S, Bouchekioua-Bouzaghou K, Goddard S, Gobert-Gosse S, Corbo L
Mol Cell. 2008
PubMed ID: 18657504
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL
EMBO J. 2008
PubMed ID: 18566587
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E
EMBO J. 2008
PubMed ID: 18566586
Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.
Tabet F, Schiffrin EL, Callera GE, He Y, Yao G, Ostman A, Kappert K, Tonks NK, Touyz RM
Circ Res. 2008
PubMed ID: 18566342
Thr308 determines Akt1 nuclear localization in insulin-stimulated keratinocytes.
Goren I, Müller E, Pfeilschifter J, Frank S
Biochem Biophys Res Commun. 2008
PubMed ID: 18477468
Lack of association between AKT1 variances versus clinical manifestations and social function in patients with schizophrenia.
Liu YC, Huang CL, Wu PL, Chang YC, Huang CH, Lane HY
J Psychopharmacol. 2008
PubMed ID: 18635704
Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.
Allard D, Figg N, Bennett MR, Littlewood TD
J Biol Chem. 2008
PubMed ID: 18458087
Myostatin directly regulates skeletal muscle fibrosis.
Li ZB, Kollias HD, Wagner KR
J Biol Chem. 2008
PubMed ID: 18453534
Constitutively active Akt induces enhanced myelination in the CNS.
Flores AI, Narayanan SP, Morse EN, Shick HE, Yin X, Kidd G, Avila RL, Kirschner DA, Macklin WB
J Neurosci. 2008
PubMed ID: 18614687
Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis.
Xia H, Diebold D, Nho R, Perlman D, Kleidon J, Kahm J, Avdulov S, Peterson M, Nerva J, Bitterman P, Henke C
J Exp Med. 2008
PubMed ID: 18541712
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
Huang J, Chen J
Oncogene. 2008
PubMed ID: 18332868
[Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin]
Ai YW, Yu HG, Yu JP, Yang Y, Li H, Hu XW, Luo HS
Zhonghua Zhong Liu Za Zhi. 2008
PubMed ID: 19062713
eIF4E knockdown decreases breast cancer cell growth without activating Akt signaling.
Soni A, Akcakanat A, Singh G, Luyimbazi D, Zheng Y, Kim D, Gonzalez-Angulo A, Meric-Bernstam F
Mol Cancer Ther. 2008
PubMed ID: 18644990
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair.
Toulany M, Kehlbach R, Florczak U, Sak A, Wang S, Chen J, Lobrich M, Rodemann HP
Mol Cancer Ther. 2008
PubMed ID: 18644989
Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.
Jiang W, Zhu Z, Thompson HJ
Cancer Res. 2008
PubMed ID: 18593953
Phosphoinositide 3-kinase/AKT signaling can promote AIB1 stability independently of GSK3 phosphorylation.
Ferrero M, Avivar A, García-Macías MC, de Mora JF
Cancer Res. 2008
PubMed ID: 18593948
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L
Nat Genet. 2008
PubMed ID: 18583979
Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarcinoma.
Huang Y, Hua K, Zhou X, Jin H, Chen X, Lu X, Yu Y, Zha X, Feng Y
Cell Res. 2008
PubMed ID: 18574502
Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas.
Völker HU, Hagemann C, Coy J, Wittig R, Sommer S, Stojic J, Haubitz I, Vince GH, Kämmerer U, Monoranu CM
Am J Clin Pathol. 2008
PubMed ID: 18550470
Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.
Kim HS, Loughran PA, Rao J, Billiar TR, Zuckerbraun BS
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18497334
Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation.
Jo H, Jia Y, Subramanian KK, Hattori H, Luo HR
Mol Cell Biol. 2008
PubMed ID: 18458059
Activation of Erk1/2 and Akt following unilateral ureteral obstruction.
Rodríguez-Peña AB, Grande MT, Eleno N, Arévalo M, Guerrero C, Santos E, López-Novoa JM
Kidney Int. 2008
PubMed ID: 18449171
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.
Du Y, Li X, Yang D, Zhang X, Chen S, Huang K, Le W
Exp Biol Med (Maywood). 2008
PubMed ID: 18445767
Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis.
Chen XL, Ren KH, He HW, Shao RG
Cancer Biol Ther. 2008
PubMed ID: 18437054
Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblasts.
Kim S, Lee Y, Seo JE, Cho KH, Chung JH
Cell Signal. 2008
PubMed ID: 18434090
AKT is activated in an ataxia-telangiectasia and Rad3-related-dependent manner in response to temozolomide and confers protection against drug-induced cell growth inhibition.
Caporali S, Levati L, Starace G, Ragone G, Bonmassar E, Alvino E, D'Atri S
Mol Pharmacol. 2008
PubMed ID: 18413665
Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.
Ramesh Babu J, Lamar Seibenhener M, Peng J, Strom AL, Kemppainen R, Cox N, Zhu H, Wooten MC, Diaz-Meco MT, Moscat J, Wooten MW
J Neurochem. 2008
PubMed ID: 18346206
In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.
Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B
J Neurochem. 2008
PubMed ID: 18346204
Cell detachment modulates TRAIL resistance in ovarian cancer cells by downregulating the phosphatidylinositol 3-kinase/Akt pathway.
Lane D, Cartier A, Rancourt C, Piché A
Int J Gynecol Cancer. 2008
PubMed ID: 17868340
Akt plays an important role in breast cancer cell chemotaxis to CXCL12.
Zhao M, Mueller BM, DiScipio RG, Schraufstatter IU
Breast Cancer Res Treat. 2008
PubMed ID: 17687643
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation.
Wittwer T, Schmitz ML
Biochem Biophys Res Commun. 2008
PubMed ID: 18439422
Leptin increases adult hippocampal neurogenesis in vivo and in vitro.
Garza JC, Guo M, Zhang W, Lu XY
J Biol Chem. 2008
PubMed ID: 18367451
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway.
Deep G, Oberlies NH, Kroll DJ, Agarwal R
Oncogene. 2008
PubMed ID: 18332867
Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53.
Shankar E, Sivaprasad U, Basu A
Oncogene. 2008
PubMed ID: 18317451
Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.
Okada M, Jang SW, Ye K
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18562279
TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3beta cascade is required for TNF-induced cell survival.
Yoon K, Jung EJ, Lee SY
Biochem Biophys Res Commun. 2008
PubMed ID: 18407828
Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.
Calippe B, Douin-Echinard V, Laffargue M, Laurell H, Rana-Poussine V, Pipy B, Guéry JC, Bayard F, Arnal JF, Gourdy P
J Immunol. 2008
PubMed ID: 18523261
Akt1 gene deletion and stroke.
Li J, Lang J, Zeng Z, McCullough LD
J Neurol Sci. 2008
PubMed ID: 18258266
Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.
Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR
J Biol Chem. 2008
PubMed ID: 18420583
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK.
Boehme KA, Kulikov R, Blattner C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18505846
Dietary energy balance modulates signaling through the Akt/mammalian target of rapamycin pathways in multiple epithelial tissues.
Moore T, Beltran L, Carbajal S, Strom S, Traag J, Hursting SD, DiGiovanni J
Cancer Prev Res (Phila Pa). 2008
PubMed ID: 19138937
Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population.
Cao Z, Song JH, Kim CJ, Cho YG, Kim SY, Nam SW, Lee JY, Park WS
APMIS. 2008
PubMed ID: 18754328
Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia.
Kohrenhagen N, Voelker HU, Schmidt M, Kapp M, Krockenberger M, Frambach T, Dietl J, Kammerer U
J Obstet Gynaecol Res. 2008
PubMed ID: 18686341
[Feiyanning Decoction down-regulates the expressions of phosphorylated Akt and hypoxia inducible factor-1alpha proteins in transplanted lung adenocarcinoma in nude mice]
Zhang M, Xu ZY, Bai B, Dong Y
Zhong Xi Yi Jie He Xue Bao. 2008
PubMed ID: 18559241
Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer.
Lee JY, Jang KS, Shin DH, Oh MY, Kim HJ, Kim Y, Kong G
Cancer Res. 2008
PubMed ID: 18519679
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.
Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS
Genes Dev. 2008
PubMed ID: 18519641
Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and the PI3-kinase/AKT pathways in multiple myeloma.
Grugan KD, Ma C, Singhal S, Krett NL, Rosen ST
J Steroid Biochem Mol Biol. 2008
PubMed ID: 18499442
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans.
Tan HY, Nicodemus KK, Chen Q, Li Z, Brooke JK, Honea R, Kolachana BS, Straub RE, Meyer-Lindenberg A, Sei Y, Mattay VS, Callicott JH, Weinberger DR
J Clin Invest. 2008
PubMed ID: 18497887
Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.
Dan HC, Baldwin AS
J Immunol. 2008
PubMed ID: 18490760
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
Schuhmacher AJ, Guerra C, Sauzeau V, Cañamero M, Bustelo XR, Barbacid M
J Clin Invest. 2008
PubMed ID: 18483625
Synthesis and structure based optimization of novel Akt inhibitors.
Lippa B, Pan G, Corbett M, Li C, Kauffman GS, Pandit J, Robinson S, Wei L, Kozina E, Marr ES, Borzillo G, Knauth E, Barbacci-Tobin EG, Vincent P, Troutman M, Baker D, Rajamohan F, Kakar S, Clark T, Morris J
Bioorg Med Chem Lett. 2008
PubMed ID: 18456494
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.
Huang J, Dibble CC, Matsuzaki M, Manning BD
Mol Cell Biol. 2008
PubMed ID: 18411301
FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.
Dufour C, Guenou H, Kaabeche K, Bouvard D, Sanjay A, Marie PJ
Bone. 2008
PubMed ID: 18374639
17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.
Shi HR, Zhu LQ, Wang SH, Liu XA, Tian Q, Zhang Q, Wang Q, Wang JZ
J Neural Transm. 2008
PubMed ID: 18217188
Bcl-xL prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity.
Wang Y, Zhang B, Peng X, Perpetua M, Harbrecht BG
J Cell Physiol. 2008
PubMed ID: 18163394
Oxidative stress induces GLUT4 translocation by activation of PI3-K/Akt and dual AMPK kinase in cardiac myocytes.
Horie T, Ono K, Nagao K, Nishi H, Kinoshita M, Kawamura T, Wada H, Shimatsu A, Kita T, Hasegawa K
J Cell Physiol. 2008
PubMed ID: 18163380
Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats.
Sui L, Wang J, Li BM
Neurochem Res. 2008
PubMed ID: 18097751
Interleukin-18 stimulates fibronectin expression in primary human cardiac fibroblasts via PI3K-Akt-dependent NF-kappaB activation.
Reddy VS, Harskamp RE, van Ginkel MW, Calhoon J, Baisden CE, Kim IS, Valente AJ, Chandrasekar B
J Cell Physiol. 2008
PubMed ID: 18064631
Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses.
Nair VD, Olanow CW
J Biol Chem. 2008
PubMed ID: 18387957
Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.
Byon CH, Javed A, Dai Q, Kappes JC, Clemens TL, Darley-Usmar VM, McDonald JM, Chen Y
J Biol Chem. 2008
PubMed ID: 18378684
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B
Nature. 2008
PubMed ID: 18449193
Down-regulation of Notch-dependent transcription by Akt in vitro.
Song J, Park S, Kim M, Shin I
FEBS Lett. 2008
PubMed ID: 18440314
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18487454
Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells.
Hara S, Nakashiro K, Goda H, Hamakawa H
Biochem Biophys Res Commun. 2008
PubMed ID: 18355439
Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.
Litherland GJ, Dixon C, Lakey RL, Robson T, Jones D, Young DA, Cawston TE, Rowan AD
J Biol Chem. 2008
PubMed ID: 18332138
Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.
Elstrott J, Anishchenko A, Greschner M, Sher A, Litke AM, Chichilnisky EJ, Feller MB
Neuron. 2008
PubMed ID: 18498732
Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding.
Lopez-Pajares V, Kim MM, Yuan ZM
J Biol Chem. 2008
PubMed ID: 18356162
cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation.
Chen L, Zhang JJ, Huang XY
J Biol Chem. 2008
PubMed ID: 18353776
Targeting AKT signaling sensitizes cancer to cellular immunotherapy.
Hähnel PS, Thaler S, Antunes E, Huber C, Theobald M, Schuler M
Cancer Res. 2008
PubMed ID: 18483275
UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes.
He YY, Council SE, Feng L, Chignell CF
Cancer Res. 2008
PubMed ID: 18483258
Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma.
Dal Col J, Zancai P, Terrin L, Guidoboni M, Ponzoni M, Pavan A, Spina M, Bergamin S, Rizzo S, Tirelli U, De Rossi A, Doglioni C, Dolcetti R
Blood. 2008
PubMed ID: 18339899
Association between AKT1 gene and Parkinson's disease: a protective haplotype.
Xiromerisiou G, Hadjigeorgiou GM, Papadimitriou A, Katsarogiannis E, Gourbali V, Singleton AB
Neurosci Lett. 2008
PubMed ID: 18395980
Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.
Fritzius T, Moelling K
EMBO J. 2008
PubMed ID: 18388859
Association of a Nonsynonymous Variant of DAOA with Visuospatial Ability in a Bipolar Family Sample.
Soronen P, Silander K, Antila M, Palo OM, Tuulio-Henriksson A, Kieseppä T, Ellonen P, Wedenoja J, Turunen JA, Pietiläinen OP, Hennah W, Lönnqvist J, Peltonen L, Partonen T, Paunio T
Biol Psychiatry. 2008
PubMed ID: 18466879
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.
Zhu J, Blenis J, Yuan J
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18451027
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias.
Kim MS, Jeong EG, Yoo NJ, Lee SH
Br J Cancer. 2008
PubMed ID: 18392055
[Hypoxia induced HIF-1 accumulation and VEGF expression in gastric epithelial mucosa cell: involvement of ERK1/2 and PI3K/Akt]
Liu L, Ning X, Han S, Zhang H, Sun L, Shi Y, Sun S, Guo C, Yin F, Qiao T, Wu K, Fan D
Mol Biol (Mosk). 2008
PubMed ID: 18702304
Musclin inhibits insulin activation of Akt/protein kinase B in rat skeletal muscle.
Liu Y, Huo X, Pang XF, Zong ZH, Meng X, Liu GL
J Int Med Res. 2008
PubMed ID: 18534131
[Expression and clinical significance of phosphatidylinositol 3-kinase and protein kinase B in cervical carcinoma]
Yao TT, Dai YZ, Li SZ
Ai Zheng. 2008
PubMed ID: 18479604
Transforming growth factor beta induces apoptosis through repressing the phosphoinositide 3-kinase/AKT/survivin pathway in colon cancer cells.
Wang J, Yang L, Yang J, Kuropatwinski K, Wang W, Liu XQ, Hauser J, Brattain MG
Cancer Res. 2008
PubMed ID: 18451140
The activation of Akt during preoperative chemotherapy for esophageal cancer correlates with poor prognosis.
Yoshioka A, Miyata H, Doki Y, Yasuda T, Yamasaki M, Motoori M, Okada K, Matsuyama J, Makari Y, Sohma I, Takiguchi S, Fujiwara Y, Monden M
Oncol Rep. 2008
PubMed ID: 18425364
Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations.
Zenz T, Döhner K, Denzel T, Döhner H, Stilgenbauer S, Bullinger L
Br J Haematol. 2008
PubMed ID: 18410456
Control of thrombin signaling through PI3K is a mechanism underlying plasticity between hair follicle dermal sheath and papilla cells.
Feutz AC, Barrandon Y, Monard D
J Cell Sci. 2008
PubMed ID: 18398001
Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum.
Greijer AE, Delis-van Diemen PM, Fijneman RJ, Giles RH, Voest EE, van Hinsbergh VW, Meijer GA
Virchows Arch. 2008
PubMed ID: 18351386
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance.
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR
Mol Cell Biol. 2008
PubMed ID: 18347057
Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide.
Arranz A, Androulidaki A, Zacharioudaki V, Martinez C, Margioris AN, Gomariz RP, Tsatsanis C
Mol Immunol. 2008
PubMed ID: 18336909
The effect of chronic nitric oxide synthases inhibition on regulatory proteins in rat hearts.
Spániková A, Simoncíková P, Ravingerová T, Pechánová O, Barancík M
Mol Cell Biochem. 2008
PubMed ID: 18327702
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
Lee CW, Lin CC, Luo SF, Lee HC, Lee IT, Aird WC, Hwang TL, Yang CM
Mol Pharmacol. 2008
PubMed ID: 18227124
The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways.
Gao X, Zhang H, Takahashi T, Hsieh J, Liao J, Steinberg GK, Zhao H
J Neurochem. 2008
PubMed ID: 18182053
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.
Bozulic L, Surucu B, Hynx D, Hemmings BA
Mol Cell. 2008
PubMed ID: 18439899
Differential roles of phosphatidylinositol 3-kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension.
Huang Y, Cen LP, Luo JM, Wang N, Zhang MZ, van Rooijen N, Pang CP, Cui Q
Neuroscience. 2008
PubMed ID: 18358617
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
Lin WN, Luo SF, Wu CB, Lin CC, Yang CM
Toxicol Appl Pharmacol. 2008
PubMed ID: 18182168
Specific LPA receptor subtype mediation of LPA-induced hypertrophy of cardiac myocytes and involvement of Akt and NFkappaB signal pathways.
Chen J, Chen Y, Zhu W, Han Y, Han B, Xu R, Deng L, Cai Y, Cong X, Yang Y, Hu S, Chen X
J Cell Biochem. 2008
PubMed ID: 17891781
Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle.
Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ
J Biol Chem. 2008
PubMed ID: 18276596
Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines.
Modak C, Bryant P
Biochem Biophys Res Commun. 2008
PubMed ID: 18262492
Regulation of DNA synthesis in mouse embryonic stem cells by transforming growth factor-alpha: involvement of the PI3-K/Akt and Notch/Wnt signaling pathways.
Heo JS, Lee SH, Han HJ
Growth Factors. 2008
PubMed ID: 18428029
Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2.
Zhang Y, Guan L, Wang X, Wen T, Xing J, Zhao J
Free Radic Res. 2008
PubMed ID: 18404535
Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathways.
Rizzatti EG, Mora-Jensen H, Weniger MA, Gibellini F, Lee E, Daibata M, Lai R, Wiestner A
Leuk Lymphoma. 2008
PubMed ID: 18398749
Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC
J Immunol. 2008
PubMed ID: 18354169
Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.
Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M
J Cell Sci. 2008
PubMed ID: 18354084
Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.
Harwood BN, Cross SK, Radford EE, Haac BE, De Vries WN
Dev Dyn. 2008
PubMed ID: 18351675
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.
Ma K, Cheung SM, Marshall AJ, Duronio V
Cell Signal. 2008
PubMed ID: 18249092
Gene and protein expression associated with protein synthesis and breakdown in paraplegic skeletal muscle.
Drummond MJ, Glynn EL, Lujan HL, Dicarlo SE, Rasmussen BB
Muscle Nerve. 2008
PubMed ID: 18236467
T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Qiao G, Li Z, Molinero L, Alegre ML, Ying H, Sun Z, Penninger JM, Zhang J
Mol Cell Biol. 2008
PubMed ID: 18227156
GSK3beta is a negative regulator of platelet function and thrombosis.
Li D, August S, Woulfe DS
Blood. 2008
PubMed ID: 18218855
Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death.
Autret A, Martin-Latil S, Brisac C, Mousson L, Colbère-Garapin F, Blondel B
J Virol. 2008
PubMed ID: 18216097
No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.
Sanders AR, Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA, Olincy A, Rozic P, Vinogradov S, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Crowe RR, Cloninger CR, Martinez M, Gejman PV
Am J Psychiatry. 2008
PubMed ID: 18198266
Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells.
Varma S, Khandelwal RL
J Cell Biochem. 2008
PubMed ID: 17721885
Role of the Akt pathway in mRNA translation of interferon-stimulated genes.
Kaur S, Sassano A, Dolniak B, Joshi S, Majchrzak-Kita B, Baker DP, Hay N, Fish EN, Platanias LC
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18339807
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.
Haxhinasto S, Mathis D, Benoist C
J Exp Med. 2008
PubMed ID: 18283119
Akt and CHIP coregulate tau degradation through coordinated interactions.
Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18292230
Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells.
Han EK, Mcgonigal T, Butler C, Giranda VL, Luo Y
Anticancer Res. 2008
PubMed ID: 18507042
An actin-binding protein Girdin regulates the motility of breast cancer cells.
Jiang P, Enomoto A, Jijiwa M, Kato T, Hasegawa T, Ishida M, Sato T, Asai N, Murakumo Y, Takahashi M
Cancer Res. 2008
PubMed ID: 18316593
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.
Kitamura T, Asai N, Enomoto A, Maeda K, Kato T, Ishida M, Jiang P, Watanabe T, Usukura J, Kondo T, Costantini F, Murohara T, Takahashi M
Nat Cell Biol. 2008
PubMed ID: 18264090
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung.
Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, De Gisi S, Malara N, Savino R, Rocco G, Chiappetta G, Franco R, Tirino V, Pirozzi G, Viglietto G
Cell Cycle. 2008
PubMed ID: 18256540
AKT signaling promotes derivation of embryonic germ cells from primordial germ cells.
Kimura T, Tomooka M, Yamano N, Murayama K, Matoba S, Umehara H, Kanai Y, Nakano T
Development. 2008
PubMed ID: 18216173
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.
Cozzone D, Fröjdö S, Disse E, Debard C, Laville M, Pirola L, Vidal H
Diabetologia. 2008
PubMed ID: 18204829
Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas.
Schüller U, Ruiter M, Herms J, Kretzschmar HA, Grasbon-Frodl E
Acta Neuropathol. 2008
PubMed ID: 18172656
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis.
Escrivà M, Peiró S, Herranz N, Villagrasa P, Dave N, Montserrat-Sentís B, Murray SA, Francí C, Gridley T, Virtanen I, García de Herreros A
Mol Cell Biol. 2008
PubMed ID: 18172008
Substrate-bound insulin-like growth factor (IGF)-I-IGF binding protein-vitronectin-stimulated breast cell migration is enhanced by coactivation of the phosphatidylinositide 3-Kinase/AKT pathway by alphav-integrins and the IGF-I receptor.
Hollier BG, Kricker JA, Van Lonkhuyzen DR, Leavesley DI, Upton Z
Endocrinology. 2008
PubMed ID: 18079201
Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling.
Prast J, Saleh L, Husslein H, Sonderegger S, Helmer H, Knöfler M
Endocrinology. 2008
PubMed ID: 18063683
Nephrin is involved in podocyte maturation but not survival during glomerular development.
Doné SC, Takemoto M, He L, Sun Y, Hultenby K, Betsholtz C, Tryggvason K
Kidney Int. 2008
PubMed ID: 18046313
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.
Thiselton DL, Vladimirov VI, Kuo PH, McClay J, Wormley B, Fanous A, O'Neill FA, Walsh D, Van den Oord EJ, Kendler KS, Riley BP
Biol Psychiatry. 2008
PubMed ID: 17825267
v-Crk induces Rac-dependent membrane ruffling and cell migration in CAS-deficient embryonic fibroblasts.
Sung BH, Yeo MG, Oh HJ, Song WK
Mol Cells. 2008
PubMed ID: 18319625
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM
Nature. 2008
PubMed ID: 18288188
Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells.
Nakaso K, Ito S, Nakashima K
Neurosci Lett. 2008
PubMed ID: 18201823
IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.
Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC
Blood. 2008
PubMed ID: 18042802
HGF protects cultured cortical neurons against hypoxia/reoxygenation induced cell injury via ERK1/2 and PI-3K/Akt pathways.
He F, Wu LX, Shu KX, Liu FY, Yang LJ, Zhou X, Zhang Y, Huang BS, Huang D, Deng XL
Colloids Surf B Biointerfaces. 2008
PubMed ID: 17942284
Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS.
Bae J, Park D, Lee YS, Jeoung D
J Microbiol Biotechnol. 2008
PubMed ID: 18309287
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.
Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K
Cell Metab. 2008
PubMed ID: 18249175
Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation.
Léger B, Derave W, De Bock K, Hespel P, Russell AP
Rejuvenation Res. 2008
PubMed ID: 18240972
Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells.
Ou CC, Hsu SC, Hsieh YH, Tsou WL, Chuang TC, Liu JY, Kao MC
Carcinogenesis. 2008
PubMed ID: 18174256
Hepatic stress in hereditary tyrosinemia type 1 (HT1) activates the AKT survival pathway in the fah-/- knockout mice model.
Orejuela D, Jorquera R, Bergeron A, Finegold MJ, Tanguay RM
J Hepatol. 2008
PubMed ID: 18093685
Carbon nanoparticle-induced lung epithelial cell proliferation is mediated by receptor-dependent Akt activation.
Unfried K, Sydlik U, Bierhals K, Weissenberg A, Abel J
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18083769
Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol.
Gagnon V, Van Themsche C, Turner S, Leblanc V, Asselin E
Apoptosis. 2008
PubMed ID: 18071906
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes.
Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q
J Mol Cell Cardiol. 2008
PubMed ID: 18054038
PI3K/AKT pathway activation in acute myeloid leukaemias is not associated with AKT1 pleckstrin homology domain mutation.
Tibes R, Kornblau SM, Qiu Y, Mousses SM, Robbins C, Moses T, Carpten JD
Br J Haematol. 2008
PubMed ID: 18053070
The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity.
Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S
Kidney Int. 2008
PubMed ID: 18046317
Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells.
Lee TJ, Lee JT, Kim SH, Choi YH, Song KS, Park JW, Kwon TK
J Cell Biochem. 2008
PubMed ID: 18041764
Dissociation of Akt/PKB and ribosomal S6 kinase signaling markers in a transgenic mouse model of Alzheimer's disease.
Damjanac M, Rioux Bilan A, Paccalin M, Pontcharraud R, Fauconneau B, Hugon J, Page G
Neurobiol Dis. 2008
PubMed ID: 18023354
Protective effect of 17beta-estradiol on ischemic acute renal failure through the PI3K/Akt/eNOS pathway.
Satake A, Takaoka M, Nishikawa M, Yuba M, Shibata Y, Okumura K, Kitano K, Tsutsui H, Fujii K, Kobuchi S, Ohkita M, Matsumura Y
Kidney Int. 2008
PubMed ID: 18004295
Impaired insulin-stimulated phosphorylation of Akt and AS160 in skeletal muscle of women with polycystic ovary syndrome is reversed by pioglitazone treatment.
Højlund K, Glintborg D, Andersen NR, Birk JB, Treebak JT, Frøsig C, Beck-Nielsen H, Wojtaszewski JF
Diabetes. 2008
PubMed ID: 17977950
Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor.
Russell ST, Eley HL, Wyke SM, Tisdale MJ
Biochem J. 2008
PubMed ID: 17961125
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy.
Kemi OJ, Ceci M, Wisloff U, Grimaldi S, Gallo P, Smith GL, Condorelli G, Ellingsen O
J Cell Physiol. 2008
PubMed ID: 17941081
TCL1 promotes blastomere proliferation through nuclear transfer, but not direct phosphorylation, of AKT/PKB in early mouse embryos.
Fiorenza MT, Torcia S, Canterini S, Bevilacqua A, Narducci MG, Ragone G, Croce CM, Russo G, Mangia F
Cell Death Differ. 2008
PubMed ID: 17901877
Akt kinase targets association of CBP with SMAD 3 to regulate TGFbeta-induced expression of plasminogen activator inhibitor-1.
Das F, Ghosh-Choudhury N, Venkatesan B, Li X, Mahimainathan L, Choudhury GG
J Cell Physiol. 2008
PubMed ID: 17671970
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.
Dajani OF, Meisdalen K, Guren TK, Aasrum M, Tveteraas IH, Lilleby P, Thoresen GH, Sandnes D, Christoffersen T
J Cell Physiol. 2008
PubMed ID: 17654493
p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation.
Ogawa E, Okuyama R, Ikawa S, Nagoshi H, Egawa T, Kurihara A, Yabuki M, Tagami H, Obinata M, Aiba S
Oncogene. 2008
PubMed ID: 17653081
Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses.
Altman JK, Yoon P, Katsoulidis E, Kroczynska B, Sassano A, Redig AJ, Glaser H, Jordan A, Tallman MS, Hay N, Platanias LC
J Biol Chem. 2008
PubMed ID: 18048359
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.
Kuo YC, Huang KY, Yang CH, Yang YS, Lee WY, Chiang CW
J Biol Chem. 2008
PubMed ID: 18042541
Complex formation of p65/RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB.
Kwon O, Kim KA, He L, Jung M, Jeong SJ, Ahn JS, Kim BY
Biochem Biophys Res Commun. 2008
PubMed ID: 18035048
RNA interference targeting tNOX attenuates cell migration via a mechanism that involves membrane association of Rac.
Liu SC, Yang JJ, Shao KN, Chueh PJ
Biochem Biophys Res Commun. 2008
PubMed ID: 18023414
Curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the PI3K/Akt/NF kappa B pathway.
Choi BH, Kim CG, Lim Y, Shin SY, Lee YH
Cancer Lett. 2008
PubMed ID: 18006147
c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway.
Jin W, Yun C, Jeong J, Park Y, Lee HD, Kim SJ
J Biol Chem. 2008
PubMed ID: 17991742
MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN.
Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ
Cancer Res. 2008
PubMed ID: 18199536
t-Darpp promotes cancer cell survival by up-regulation of Bcl2 through Akt-dependent mechanism.
Belkhiri A, Dar AA, Zaika A, Kelley M, El-Rifai W
Cancer Res. 2008
PubMed ID: 18199533
Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.
Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK
J Cell Sci. 2008
PubMed ID: 18187454
Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats.
Pauli JR, Ropelle ER, Cintra DE, Carvalho-Filho MA, Moraes JC, De Souza CT, Velloso LA, Carvalheira JB, Saad MJ
J Physiol. 2008
PubMed ID: 17974582
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival.
Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB
Blood. 2008
PubMed ID: 17942753
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells.
Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG
Blood. 2008
PubMed ID: 17928528
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation.
Yin H, Stojanovic A, Hay N, Du X
Blood. 2008
PubMed ID: 17914025
EGFR and beta1 integrins utilize different signaling pathways to activate Akt.
Velling T, Stefansson A, Johansson S
Exp Cell Res. 2008
PubMed ID: 17910952
Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.
Wang S, Basson MD
Exp Cell Res. 2008
PubMed ID: 17825284
A beta-arrestin 2 signaling complex mediates lithium action on behavior.
Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG
Cell. 2008
PubMed ID: 18191226
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.
Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S
EMBO J. 2008
PubMed ID: 18059474
A model for obesity and gigantism due to disruption of the Ankrd26 gene.
Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18162531
Akt regulates drug-induced cell death through Bcl-w downregulation.
Garofalo M, Quintavalle C, Zanca C, De Rienzo A, Romano G, Acunzo M, Puca L, Incoronato M, Croce CM, Condorelli G
PLoS ONE. 2008
PubMed ID: 19114998
Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight.
Jensen CB, Martin-Gronert MS, Storgaard H, Madsbad S, Vaag A, Ozanne SE
PLoS ONE. 2008
PubMed ID: 19011679
Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus.
Saeed MF, Kolokoltsov AA, Freiberg AN, Holbrook MR, Davey RA
PLoS Pathog. 2008
PubMed ID: 18769720
Hemangiopoietin promotes endothelial cell proliferation through PI-3K/Akt pathway.
Chen Z, Liu F, Ren Q, Zhao Q, Ren H, Lu S, Zhang L, Han Z
Cell Physiol Biochem. 2008
PubMed ID: 18769058
Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration.
Inoue T, Meyer T
PLoS ONE. 2008
PubMed ID: 18728784
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N
PLoS ONE. 2008
PubMed ID: 18725974
Immunoexpression of HER family, neuregulin, MAPK and AKT in invasive ductal carcinomas of the breast.
Kaya H, Erbarut I, Ozkan N, Bekiroğlu N, Sen S, Abaciğlu U
Eur J Gynaecol Oncol. 2008
PubMed ID: 18714568
Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3.
Young CD, Nolte EC, Lewis A, Serkova NJ, Anderson SM
Breast Cancer Res. 2008
PubMed ID: 18700973
Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.
Do H, Solomon B, Mitchell PL, Fox SB, Dobrovic A
BMC Res Notes. 2008
PubMed ID: 18611285
Bioactive peptides control receptor for advanced glycated end product-induced elevation of kidney insulin receptor substrate 2 and reduce albuminuria in diabetic mice.
Singh BK, Mascarenhas DD
Am J Nephrol. 2008
PubMed ID: 18566543
HTLV-I production based on activation of integrin/ligand signaling in HTLV-I-infected T cell lines derived from HAM/TSP patients.
Fukushima N, Nakamura T, Nishiura Y, Ida H, Aramaki T, Eguchi K
Intervirology. 2008
PubMed ID: 18552504
Angiogenic-regulatory network revealed by molecular profiling heart tissue following Akt1 induction in endothelial cells.
Schiekofer S, Belisle K, Galasso G, Schneider JG, Boehm BO, Burster T, Schmitz G, Walsh K
Angiogenesis. 2008
PubMed ID: 18491207
Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing.
Somanath PR, Chen J, Byzova TV
Angiogenesis. 2008
PubMed ID: 18415691
The potential role of Akt phosphorylation in human cancers.
Cicenas J
Int J Biol Markers. 2008
PubMed ID: 18409144
Alteration in protein kinase B (AKT) activity in platelets from patients with systemic sclerosis.
Chiang TM, Postlethwaite AE
Thromb Res. 2008
PubMed ID: 18355897
Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis.
Parkhouse WS, Cunningham L, McFee I, Miller JM, Whitney D, Pelech SL, Krieger C
Amyotroph Lateral Scler. 2008
PubMed ID: 18273716
Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas.
Folgiero V, Avetrani P, Bon G, Di Carlo SE, Fabi A, Nisticò C, Vici P, Melucci E, Buglioni S, Perracchio L, Sperduti I, Rosanò L, Sacchi A, Mottolese M, Falcioni R
PLoS ONE. 2008
PubMed ID: 18270579
Progesterone potentiates IP(3)-mediated calcium signaling through Akt/PKB.
Koulen P, Madry C, Duncan RS, Hwang JY, Nixon E, McClung N, Gregg EV, Singh M
Cell Physiol Biochem. 2008
PubMed ID: 18209483
PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation.
Ouyang W, Luo W, Zhang D, Jian J, Ma Q, Li J, Shi X, Chen J, Gao J, Huang C
Environ Health Perspect. 2008
PubMed ID: 18197291
Tissue microarray based analysis of prognostic markers in invasive bladder cancer: much effort to no avail?
Liedberg F, Anderson H, Chebil G, Gudjonsson S, Höglund M, Lindgren D, Lundberg LM, Lövgren K, Fernö M, Månsson W
Urol Oncol. 2008
PubMed ID: 18190825
Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer.
Wu Y, Mohamed H, Chillar R, Ali I, Clayton S, Slamon D, Vadgama JV
Breast Cancer Res. 2008
PubMed ID: 18184439
Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation.
Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, Liu JO, Yi Q, Yu L
J Immunol. 2008
PubMed ID: 18097023
Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner.
Di Fulvio M, Frondorf K, Gomez-Cambronero J
Cell Signal. 2008
PubMed ID: 18006275
Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
Misra UK, Kaczowka SJ, Pizzo SV
Cell Signal. 2008
PubMed ID: 17993260
Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall.
Albinsson S, Nordström I, Swärd K, Hellstrand P
Am J Physiol Cell Physiol. 2008
PubMed ID: 17989209
Sex differences in the mechanism of Met5-enkephalin-induced cardioprotection: role of PI3K/Akt.
Cao Z, Liu L, Packwood W, Merkel M, Hurn PD, Van Winkle DM
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 17982014
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy.
Spangenburg EE, Le Roith D, Ward CW, Bodine SC
J Physiol. 2008
PubMed ID: 17974583
Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.
Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana JL, Lara MF, Carbajal S, Martínez-Cruz AB, García-Escudero R, Beltran L, Segovia JC, Bravo A, DiGiovanni J, Paramio JM
Mol Biol Cell. 2008
PubMed ID: 17959825
Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses.
Sun M, Fuentes SM, Timani K, Sun D, Murphy C, Lin Y, August A, Teng MN, He B
J Virol. 2008
PubMed ID: 17959676
Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1.
Tang D, Lu J, Walterscheid JP, Chen HH, Engler DA, Sawamura T, Chang PY, Safi HJ, Yang CY, Chen CH
J Lipid Res. 2008
PubMed ID: 17909223
Enhanced angiotensin converting enzyme 2 regulates the insulin/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression.
Zhong JC, Yu XY, Lin QX, Li XH, Huang XZ, Xiao DZ, Lin SG
Br J Pharmacol. 2008
PubMed ID: 17906677
Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis.
Buitenhuis M, Verhagen LP, van Deutekom HW, Castor A, Verploegen S, Koenderman L, Jacobsen SE, Coffer PJ
Blood. 2008
PubMed ID: 17890457
Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.
Strumane K, Song JY, Baas I, Collard JG
Leuk Res. 2008
PubMed ID: 17521720
Increased expression of a proline-rich Akt substrate (PRAS40) in human copper/zinc-superoxide dismutase transgenic rats protects motor neurons from death after spinal cord injury.
Yu F, Narasimhan P, Saito A, Liu J, Chan PH
J Cereb Blood Flow Metab. 2008
PubMed ID: 17457363
Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt.
Kim CS, Kim JK, Nam SY, Yang KH, Jeong M, Kim HS, Kim CS, Jin YW, Kim J
Mol Cells. 2007
PubMed ID: 18182859
Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success.
Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK
J Biol Chem. 2007
PubMed ID: 17965409
RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells.
Saitoh Y, Koizumi K, Sakurai H, Minami T, Saiki I
Biochem Biophys Res Commun. 2007
PubMed ID: 17963723
Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and Akt activation.
Liu L, Zhang XJ, Jiang SR, Ding ZN, Ding GX, Huang J, Cheng YL
Chin Med J (Engl). 2007
PubMed ID: 18167217
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway.
Hers I
Blood. 2007
PubMed ID: 17827393
The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia.
Leleu X, Jia X, Runnels J, Ngo HT, Moreau AS, Farag M, Spencer JA, Pitsillides CM, Hatjiharissi E, Roccaro A, O'Sullivan G, McMillin DW, Moreno D, Kiziltepe T, Carrasco R, Treon SP, Hideshima T, Anderson KC, Lin CP, Ghobrial IM
Blood. 2007
PubMed ID: 17761832
Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.
Patel H, Polanco-Echeverry G, Segditsas S, Volikos E, McCart A, Lai C, Guenther T, Zaitoun A, Sieber O, Ilyas M, Northover J, Silver A
Int J Cancer. 2007
PubMed ID: 17721920
Critical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages.
Ha SD, Ng D, Pelech SL, Kim SO
J Biol Chem. 2007
PubMed ID: 17951252
Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation.
Seo YJ, Koh SH, Kang HJ, Shin HY, Jeong G, Ahn HS
Biochem Biophys Res Commun. 2007
PubMed ID: 17950696
Reversal of multidrug resistance and inhibition of phosphorylation of AKT in human ovarian cancer cell line by wild-type PTEN gene.
Wu H, Weng D, Xing H
J Huazhong Univ Sci Technolog Med Sci. 2007
PubMed ID: 18231751
Activation of epidermal akt by diverse mouse skin tumor promoters.
Lu J, Rho O, Wilker E, Beltran L, Digiovanni J
Mol Cancer Res. 2007
PubMed ID: 18171992
Green tea polyphenol and epigallocatechin gallate induce apoptosis and inhibit invasion in human breast cancer cells.
Thangapazham RL, Passi N, Maheshwari RK
Cancer Biol Ther. 2007
PubMed ID: 18059161
Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease.
Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC
Cell Metab. 2007
PubMed ID: 18054314
Invasion of HeLa cells by group B streptococcus requires the phosphoinositide-3-kinase signalling pathway and modulates phosphorylation of host-cell Akt and glycogen synthase kinase-3.
Burnham CA, Shokoples SE, Tyrrell GJ
Microbiology. 2007
PubMed ID: 18048937
Pim-1 regulates cardiomyocyte survival downstream of Akt.
Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA
Nat Med. 2007
PubMed ID: 18037896
Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death.
Maddika S, Bay GH, Kroczak TJ, Ande SR, Maddika S, Wiechec E, Gibson SB, Los M
Cell Prolif. 2007
PubMed ID: 18021174
BCL-2 functions as an activator of the AKT signaling pathway in pancreatic cancer.
Mortenson MM, Galante JG, Gilad O, Schlieman MG, Virudachalam S, Kung HJ, Bold RJ
J Cell Biochem. 2007
PubMed ID: 17960583
Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway.
Shang Y, Wu Y, Yao S, Wang X, Feng D, Yang W
Apoptosis. 2007
PubMed ID: 17952604
Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss.
Mori N, Kyo S, Sakaguchi J, Mizumoto Y, Ohno S, Maida Y, Hashimoto M, Takakura M, Inoue M
Cancer Sci. 2007
PubMed ID: 17924977
VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.
Findley CM, Cudmore MJ, Ahmed A, Kontos CD
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17901375
Increased phosphorylation of Akt in triple-negative breast cancers.
Umemura S, Yoshida S, Ohta Y, Naito K, Osamura RY, Tokuda Y
Cancer Sci. 2007
PubMed ID: 17892507
Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway.
Lin YF, Zhang N, Guo HS, Kong DS, Jiang T, Liang W, Zhao ZH, Tang QQ, Ma D
Apoptosis. 2007
PubMed ID: 17885802
Protease-activated receptor-induced Akt activation--regulation and possible function.
Reséndiz JC, Kroll MH, Lassila R
J Thromb Haemost. 2007
PubMed ID: 17883592
Ovariectomy augments pressure overload-induced hypertrophy associated with changes in Akt and nitric oxide synthase signaling pathways in female rats.
Bhuiyan MS, Shioda N, Fukunaga K
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17878225
PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.
Fang J, Ding M, Yang L, Liu LZ, Jiang BH
Cell Signal. 2007
PubMed ID: 17826033
Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal.
Kawasaki A, Torii K, Yamashita Y, Nishizawa K, Kanekura K, Katada M, Ito M, Nishimoto I, Terashita K, Aiso S, Matsuoka M
Cell Signal. 2007
PubMed ID: 17804197
Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.
Morisco C, Marrone C, Trimarco V, Crispo S, Monti MG, Sadoshima J, Trimarco B
Cardiovasc Res. 2007
PubMed ID: 17698050
Stretch-induced alveolar type II cell apoptosis: role of endogenous bradykinin and PI3K-Akt signaling.
Hammerschmidt S, Kuhn H, Gessner C, Seyfarth HJ, Wirtz H
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17630321
PKB/Akt inhibits ceramide-induced apoptosis in neuroblastoma cells by blocking apoptosis-inducing factor (AIF) translocation.
Kim NH, Kim K, Park WS, Son HS, Bae Y
J Cell Biochem. 2007
PubMed ID: 17471535
The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity.
Li J, Wei H, Chesley A, Moon C, Krawczyk M, Volkova M, Ziman B, Margulies KB, Talan M, Crow MT, Boheler KR
J Biol Chem. 2007
PubMed ID: 17925408
Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses.
Jensen M, Hansen B, De Meyts P, Schäffer L, Ursø B
J Biol Chem. 2007
PubMed ID: 17925406
Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility.
Basile JR, Gavard J, Gutkind JS
J Biol Chem. 2007
PubMed ID: 17855350
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.
Kuijl C, Savage ND, Marsman M, Tuin AW, Janssen L, Egan DA, Ketema M, van den Nieuwendijk R, van den Eeden SJ, Geluk A, Poot A, van der Marel G, Beijersbergen RL, Overkleeft H, Ottenhoff TH, Neefjes J
Nature. 2007
PubMed ID: 18046412
KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway.
Bauer S, Duensing A, Demetri GD, Fletcher JA
Oncogene. 2007
PubMed ID: 17546049
A cell cycle regulatory network controlling NF-kappaB subunit activity and function.
Barré B, Perkins ND
EMBO J. 2007
PubMed ID: 17962807
Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner.
Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18006659
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.
Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltrán L, Martínez-Cruz AB, García-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J
Cancer Res. 2007
PubMed ID: 18006833
Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation.
Chhipa RR, Kumari R, Upadhyay AK, Bhat MK
Exp Cell Res. 2007
PubMed ID: 17935714
Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling.
McClung JM, Kavazis AN, Whidden MA, DeRuisseau KC, Falk DJ, Criswell DS, Powers SK
J Physiol. 2007
PubMed ID: 17916612
IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase.
Hodge DR, Cho E, Copeland TD, Guszczynski T, Yang E, Seth AK, Farrar WL
Cancer Genomics Proteomics. 2007
PubMed ID: 18204201
Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.
Li HH, Willis MS, Lockyer P, Miller N, McDonough H, Glass DJ, Patterson C
J Clin Invest. 2007
PubMed ID: 17965779
Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway.
Das M, Scappini E, Martin NP, Wong KA, Dunn S, Chen YJ, Miller SL, Domin J, O'Bryan JP
Mol Cell Biol. 2007
PubMed ID: 17875942
Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms.
Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, Watson RW
Prostate. 2007
PubMed ID: 17823925
Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes.
Liu L, Zhao X, Pierre SV, Askari A
Am J Physiol Cell Physiol. 2007
PubMed ID: 17728397
Akt phosphorylation is required for heat acclimation-induced neuroprotection.
Shein NA, Tsenter J, Alexandrovich AG, Horowitz M, Shohami E
J Neurochem. 2007
PubMed ID: 17725578
Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.
Sun L, Zhao H, Xu Z, Liu Q, Liang Y, Wang L, Cai X, Zhang L, Hu L, Wang G, Zha X
Cell Signal. 2007
PubMed ID: 17716861
FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes.
Goldstein M, Meller I, Orr-Urtreger A
Genes Chromosomes Cancer. 2007
PubMed ID: 17696196
Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context.
Theodoraki MA, Kunjappu M, Sternberg DW, Caplan AJ
Exp Cell Res. 2007
PubMed ID: 17643429
Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.
Li Y, Chandrakanthan V, Day ML, O'Neill C
Biol Reprod. 2007
PubMed ID: 17634444
Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.
Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
Am J Physiol Cell Physiol. 2007
PubMed ID: 17615157
Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt.
Zingarelli B, Hake PW, Mangeshkar P, O'Connor M, Burroughs TJ, Piraino G, Denenberg A, Wong HR
Shock. 2007
PubMed ID: 17589386
Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.
Gao H, Yu Z, Bi D, Jiang L, Cui Y, Sun J, Ma R
Mol Cell Biochem. 2007
PubMed ID: 17577629
Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes.
Kim NH, Jeon S, Lee HJ, Lee AY
J Invest Dermatol. 2007
PubMed ID: 17522703
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR
EMBO J. 2007
PubMed ID: 17932490
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.
Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL
Mol Cell. 2007
PubMed ID: 17964260
Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
Jang SW, Yang SJ, Srinivasan S, Ye K
J Biol Chem. 2007
PubMed ID: 17726016
Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase/Akt signaling pathway and AP-2 transcription factor.
Park MJ, Kwak HJ, Lee HC, Yoo DH, Park IC, Kim MS, Lee SH, Rhee CH, Hong SI
J Biol Chem. 2007
PubMed ID: 17666398
Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2.
Lee IH, Dinudom A, Sanchez-Perez A, Kumar S, Cook DI
J Biol Chem. 2007
PubMed ID: 17715136
Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.
Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH
Cell Stem Cell. 2007
PubMed ID: 18371380
A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.
Depaux A, Regnier-Ricard F, Germani A, Varin-Blank N
Oncogene. 2007
PubMed ID: 17533377
Heparanase induces Akt phosphorylation via a lipid raft receptor.
Ben-Zaken O, Gingis-Velitski S, Vlodavsky I, Ilan N
Biochem Biophys Res Commun. 2007
PubMed ID: 17689495
Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains.
Cinar B, Mukhopadhyay NK, Meng G, Freeman MR
J Biol Chem. 2007
PubMed ID: 17635910
HoxA5 stabilizes adherens junctions via increased Akt1.
Arderiu G, Cuevas I, Chen A, Carrio M, East L, Boudreau NJ
Cell Adh Migr. 2007
PubMed ID: 19262140
[P2Y purinergic receptor activated PI-3K/Akt signaling pathway in regulation of growth and invasion of prostatic cancer]
Wang YX, Shi YH, Gong LH, Li Y, Heng WJ, You JF, Zhong HH, Fang WG
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 18194602
Following the tracks of AKT1 gene.
Vogiatzi P, Giordano A
Cancer Biol Ther. 2007
PubMed ID: 17921701
Dissociation of gemcitabine sensitivity and protein kinase B signaling in pancreatic ductal adenocarcinoma models.
Pham NA, Tsao MS, Cao P, Hedley DW
Pancreas. 2007
PubMed ID: 17895832
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
Tang X, Jang SW, Wang X, Liu Z, Bahr SM, Sun SY, Brat D, Gutmann DH, Ye K
Nat Cell Biol. 2007
PubMed ID: 17891137
Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB.
Facchin S, Ruzzene M, Peggion C, Sartori G, Carignani G, Marin O, Brustolon F, Lopreiato R, Pinna LA
Cell Mol Life Sci. 2007
PubMed ID: 17712528
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.
Jossin Y, Goffinet AM
Mol Cell Biol. 2007
PubMed ID: 17698586
Co-existence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma.
He L, Fan C, Gillis A, Feng X, Sanatani M, Hotte S, Kapoor A, Tang D
Biochim Biophys Acta. 2007
PubMed ID: 17681738
Akt activation and augmented fibronectin production in hyperhexosemia.
Xin X, Chen S, Khan ZA, Chakrabarti S
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17666488
CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation.
Subramaniam V, Vincent IR, Gardner H, Chan E, Dhamko H, Jothy S
Exp Mol Pathol. 2007
PubMed ID: 17599831
Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion.
Shukla S, Maclennan GT, Hartman DJ, Fu P, Resnick MI, Gupta S
Int J Cancer. 2007
PubMed ID: 17551921
Epidermal growth factor receptor pathway mitigates UVA-induced G2/M arrest in keratinocyte cells.
Jean C, Hernandez-Pigeon H, Blanc A, Charveron M, Laurent G
J Invest Dermatol. 2007
PubMed ID: 17495959
Upregulation of hypoxia-inducible factors in normal and psoriatic skin.
Rosenberger C, Solovan C, Rosenberger AD, Jinping L, Treudler R, Frei U, Eckardt KU, Brown LF
J Invest Dermatol. 2007
PubMed ID: 17495954
Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice.
Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L
Circ Res. 2007
PubMed ID: 17673674
Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo.
Schaeper U, Vogel R, Chmielowiec J, Huelsken J, Rosario M, Birchmeier W
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17881575
Leptin induces CD40 expression through the activation of Akt in murine dendritic cells.
Lam QL, Zheng BJ, Jin DY, Cao X, Lu L
J Biol Chem. 2007
PubMed ID: 17660512
Leupaxin negatively regulates B cell receptor signaling.
Chew V, Lam KP
J Biol Chem. 2007
PubMed ID: 17640867
High glucose enhances MMP-2 production in adventitial fibroblasts via Akt1-dependent NF-kappaB pathway.
Lee SJ, Bae SS, Kim KH, Lee WS, Rhim BY, Hong KW, Kim CD
FEBS Lett. 2007
PubMed ID: 17692316
Akt phosphorylates Connexin43 on Ser373, a "mode-1" binding site for 14-3-3.
Park DJ, Wallick CJ, Martyn KD, Lau AF, Jin C, Warn-Cramer BJ
Cell Commun Adhes. 2007
PubMed ID: 18163231
[Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]
Liu C, Zhou S, Ke CS, Li NP, Wu RL
Ai Zheng. 2007
PubMed ID: 17927847
Association of AKT1 gene polymorphisms with risk of schizophrenia and with response to antipsychotics in the Chinese population.
Xu MQ, Xing QH, Zheng YL, Li S, Gao JJ, He G, Guo TW, Feng GY, Xu F, He L
J Clin Psychiatry. 2007
PubMed ID: 17915974
HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells.
Hsu MC, Chang HC, Hung WC
Endocr Relat Cancer. 2007
PubMed ID: 17914096
T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis.
Harris J, De Haro SA, Master SS, Keane J, Roberts EA, Delgado M, Deretic V
Immunity. 2007
PubMed ID: 17892853
Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.
O'Shaughnessy RF, Akgũl B, Storey A, Pfister H, Harwood CA, Byrne C
Cancer Res. 2007
PubMed ID: 17804734
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM
Dev Biol. 2007
PubMed ID: 17662267
PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation.
Peltier J, O'Neill A, Schaffer DV
Dev Neurobiol. 2007
PubMed ID: 17638387
Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC.
Ciccarelli M, Cipolletta E, Santulli G, Campanile A, Pumiglia K, Cervero P, Pastore L, Astone D, Trimarco B, Iaccarino G
Cell Signal. 2007
PubMed ID: 17629454
Collagen I induction by high glucose levels is mediated by epidermal growth factor receptor and phosphoinositide 3-kinase/Akt signalling in mesangial cells.
Wu D, Peng F, Zhang B, Ingram AJ, Gao B, Krepinsky JC
Diabetologia. 2007
PubMed ID: 17622510
p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal.
Diehl KM, Grewal N, Ethier SP, Woods-Ignatoski KM
J Surg Res. 2007
PubMed ID: 17612563
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway.
Guo H, Zhou T, Jiang D, Cuconati A, Xiao GH, Block TM, Guo JT
J Virol. 2007
PubMed ID: 17609269
Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.
Peffley DM, Sharma C, Hentosh P, Buechler RD
Arch Biochem Biophys. 2007
PubMed ID: 17601486
Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells.
Gong J, Lee J, Akio H, Schlegel PN, Shen R
Endocrinology. 2007
PubMed ID: 17584963
Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway.
Doepfner KT, Spertini O, Arcaro A
Leukemia. 2007
PubMed ID: 17581609
Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.
Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF
Mol Endocrinol. 2007
PubMed ID: 17579213
R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1.
Artwohl M, Muth K, Kosulin K, de Martin R, Hölzenbein T, Rainer G, Freudenthaler A, Huttary N, Schmetterer L, Waldhäusl WK, Baumgartner-Parzer SM
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17566113
p27kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice.
Rajareddy S, Reddy P, Du C, Liu L, Jagarlamudi K, Tang W, Shen Y, Berthet C, Peng SL, Kaldis P, Liu K
Mol Endocrinol. 2007
PubMed ID: 17565040
Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways.
Zeidan A, Paylor B, Steinhoff KJ, Javadov S, Rajapurohitam V, Chakrabarti S, Karmazyn M
J Pharmacol Exp Ther. 2007
PubMed ID: 17562852
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury.
Wang XT, Pei DS, Xu J, Guan QH, Sun YF, Liu XM, Zhang GY
Cell Signal. 2007
PubMed ID: 17555943
Involvement of protein kinase B/AKT in early development of mouse fertilized eggs.
Feng C, Yu A, Liu Y, Zhang J, Zong Z, Su W, Zhang Z, Yu D, Sun QY, Yu B
Biol Reprod. 2007
PubMed ID: 17554083
Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
Jorgensen ND, Andresen JM, Pitt JE, Swenson MA, Zoghbi HY, Orr HT
J Neurochem. 2007
PubMed ID: 17540008
IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation.
Borowiec AS, Hague F, Harir N, Guénin S, Guerineau F, Gouilleux F, Roudbaraki M, Lassoued K, Ouadid-Ahidouch H
J Cell Physiol. 2007
PubMed ID: 17520698
Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK.
Su H, Sun X, Ma H, Zhang HF, Yu QJ, Huang C, Wang XM, Luan RH, Jia GL, Wang HC, Gao F
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17519283
Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.
Carabeo RA, Dooley CA, Grieshaber SS, Hackstadt T
Cell Microbiol. 2007
PubMed ID: 17501982
Parathyroid hormone-related protein induces cell survival in human renal cell carcinoma through the PI3K Akt pathway: evidence for a critical role for integrin-linked kinase and nuclear factor kappa B.
Agouni A, Sourbier C, Danilin S, Rothhut S, Lindner V, Jacqmin D, Helwig JJ, Lang H, Massfelder T
Carcinogenesis. 2007
PubMed ID: 17468516
AKT and MAPK signaling in KGF-treated and UVB-exposed human epidermal cells.
Lotti LV, Rotolo S, Francescangeli F, Frati L, Torrisi MR, Marchese C
J Cell Physiol. 2007
PubMed ID: 17458890
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways.
Bouchard V, Demers MJ, Thibodeau S, Laquerre V, Fujita N, Tsuruo T, Beaulieu JF, Gauthier R, Vézina A, Villeneuve L, Vachon PH
J Cell Physiol. 2007
PubMed ID: 17443665
Akt is involved in the inhibition of cell proliferation by EGF.
Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY
Exp Mol Med. 2007
PubMed ID: 17934337
PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH
J Biol Chem. 2007
PubMed ID: 17599906
Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts.
Tang CH, Lu DY, Tan TW, Fu WM, Yang RS
J Biol Chem. 2007
PubMed ID: 17588951
Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1.
Dong B, Valencia CA, Liu R
J Biol Chem. 2007
PubMed ID: 17580302
Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2.
Turdi S, Li Q, Lopez FL, Ren J
Life Sci. 2007
PubMed ID: 17765928
TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta.
Naiki T, Saijou E, Miyaoka Y, Sekine K, Miyajima A
J Biol Chem. 2007
PubMed ID: 17576771
GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.
Lin CF, Chen CL, Chiang CW, Jan MS, Huang WC, Lin YS
J Cell Sci. 2007
PubMed ID: 17666435
Identification of peripherin as a Akt substrate in neurons.
Konishi H, Namikawa K, Shikata K, Kobatake Y, Tachibana T, Kiyama H
J Biol Chem. 2007
PubMed ID: 17569669
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.
Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J
J Biol Chem. 2007
PubMed ID: 17565979
The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells.
Dormond O, Madsen JC, Briscoe DM
J Biol Chem. 2007
PubMed ID: 17553806
Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling.
Wang SJ, Wang SH, Song ZF, Liu XW, Wang R, Chi ZF
Neuroreport. 2007
PubMed ID: 17632284
Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly.
Somanath PR, Kandel ES, Hay N, Byzova TV
J Biol Chem. 2007
PubMed ID: 17562714
Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.
Romanelli RJ, LeBeau AP, Fulmer CG, Lazzarino DA, Hochberg A, Wood TL
J Biol Chem. 2007
PubMed ID: 17545147
EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3K/Akt.
Martín-Orozco RM, Almaraz-Pro C, Rodríguez-Ubreva FJ, Cortés MA, Ropero S, Colomer R, López-Ruiz P, Colás B
Neoplasia. 2007
PubMed ID: 17898861
Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.
Little SE, Bax DA, Rodriguez-Pinilla M, Natrajan R, Messahel B, Pritchard-Jones K, Vujanic GM, Reis-Filho JS, Jones C
Clin Cancer Res. 2007
PubMed ID: 17646270
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.
Hirsch E, Costa C, Ciraolo E
J Endocrinol. 2007
PubMed ID: 17641274
Dopamine depletion and subsequent treatment with L-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum.
Bychkov E, Ahmed MR, Dalby KN, Gurevich EV
J Neurochem. 2007
PubMed ID: 17630981
Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats.
Xu JT, Tu HY, Xin WJ, Liu XG, Zhang GH, Zhai CH
Exp Neurol. 2007
PubMed ID: 17628541
Chemotherapeutic stress selectively activates NF-kappa B-dependent AKT and VEGF expression in liver cancer-derived endothelial cells.
Meng F, Henson R, Patel T
Am J Physiol Cell Physiol. 2007
PubMed ID: 17537803
Pertussis toxin promotes macrophage survival through inhibition of acid sphingomyelinase and activation of the phosphoinositide 3-kinase/protein kinase B pathway.
Wang SW, Parhar K, Chiu KJ, Tran A, Gangoiti P, Kong J, Gonzalez M, Salh B, Duronio V, Steinbrecher UP, Gómez-Muñoz A
Cell Signal. 2007
PubMed ID: 17521884
Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.
Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF
Diabetes. 2007
PubMed ID: 17513702
Remnant lipoproteins stimulate proliferation and activate MAPK and Akt signaling pathways via G protein-coupled receptor in PC-3 prostate cancer cells.
Sekine Y, Koike H, Nakano T, Nakajima K, Suzuki K
Clin Chim Acta. 2007
PubMed ID: 17512923
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.
Giani JF, Gironacci MM, Muñoz MC, Peña C, Turyn D, Dominici FP
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17496209
Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.
Grijelmo C, Rodrigue C, Svrcek M, Bruyneel E, Hendrix A, de Wever O, Gespach C
Cell Signal. 2007
PubMed ID: 17478078
NF-kappaB inhibition enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin.
He L, Kim BY, Kim KA, Kwon O, Kim SO, Bae EY, Lee MS, Kim MS, Jung M, Moon A, Bae K, Ahn JS
Cell Signal. 2007
PubMed ID: 17462862
Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells.
Zhang B, Peng F, Wu D, Ingram AJ, Gao B, Krepinsky JC
Cell Signal. 2007
PubMed ID: 17446044
Proto-oncogene TCL1: more than just a coactivator for Akt.
Noguchi M, Ropars V, Roumestand C, Suizu F
FASEB J. 2007
PubMed ID: 17360849
Regulation of the Pro-apoptotic scaffolding protein POSH by Akt.
Lyons TR, Thorburn J, Ryan PW, Thorburn A, Anderson SM, Kassenbrock CK
J Biol Chem. 2007
PubMed ID: 17535800
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE
Nature. 2007
PubMed ID: 17611497
Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity.
Ichihara S, Yamada Y, Kawai Y, Osawa T, Furuhashi K, Duan Z, Ichihara G
Biochem Biophys Res Commun. 2007
PubMed ID: 17531194
Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells.
Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP, Sarkar FH
J Biol Chem. 2007
PubMed ID: 17522055
Akt-mediated liver growth promotes induction of cyclin E through a novel translational mechanism and a p21-mediated cell cycle arrest.
Mullany LK, Nelsen CJ, Hanse EA, Goggin MM, Anttila CK, Peterson M, Bitterman PB, Raghavan A, Crary GS, Albrecht JH
J Biol Chem. 2007
PubMed ID: 17517888
Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation.
Kao GD, Jiang Z, Fernandes AM, Gupta AK, Maity A
J Biol Chem. 2007
PubMed ID: 17513297
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.
Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17609365
BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia.
Chu S, Li L, Singh H, Bhatia R
Cancer Res. 2007
PubMed ID: 17638918
[The correlation study of PTEN gene expression and Akt phosphorylation in myelodysplastic syndrome]
Chen BG, Zhu M, Luo WD, Yan WH, Zhou MY, Li BL, Tao DD
Zhonghua Xue Ye Xue Za Zhi. 2007
PubMed ID: 18072631
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway.
Liu LZ, Zhou XD, Qian G, Shi X, Fang J, Jiang BH
Cancer Res. 2007
PubMed ID: 17616691
Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.
Dan HC, Adli M, Baldwin AS
Cancer Res. 2007
PubMed ID: 17616684
Cholesterol sensitivity of endogenous and myristoylated Akt.
Adam RM, Mukhopadhyay NK, Kim J, Di Vizio D, Cinar B, Boucher K, Solomon KR, Freeman MR
Cancer Res. 2007
PubMed ID: 17616681
Determining risk of biochemical recurrence in prostate cancer by immunohistochemical detection of PTEN expression and Akt activation.
Bedolla R, Prihoda TJ, Kreisberg JI, Malik SN, Krishnegowda NK, Troyer DA, Ghosh PM
Clin Cancer Res. 2007
PubMed ID: 17606718
Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression.
Park SS, Kim SW
Oncol Rep. 2007
PubMed ID: 17549359
Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability.
Barry RE, Allan BB, Cummins EP, Kattla JJ, Giblin A, Scally N, Taylor CT, Brazil DP
Eur J Cell Biol. 2007
PubMed ID: 17544543
Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2.
Miraglia AG, Travaglione S, Meschini S, Falzano L, Matarrese P, Quaranta MG, Viora M, Fiorentini C, Fabbri A
Mol Biol Cell. 2007
PubMed ID: 17507655
A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.
McArthur T, Ohtoshi A
Mol Cell Biol. 2007
PubMed ID: 17485440
A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.
Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY, Yang-Yen HF
Mol Biol Cell. 2007
PubMed ID: 17475776
p27Kip1 localization depends on the tumor suppressor protein tuberin.
Rosner M, Freilinger A, Hanneder M, Fujita N, Lubec G, Tsuruo T, Hengstschläger M
Hum Mol Genet. 2007
PubMed ID: 17470459
Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity.
Palazzolo I, Burnett BG, Young JE, Brenne PL, La Spada AR, Fischbeck KH, Howell BW, Pennuto M
Hum Mol Genet. 2007
PubMed ID: 17470458
Cholesterol level of lipid raft microdomains regulates apoptotic cell death in prostate cancer cells through EGFR-mediated Akt and ERK signal transduction.
Oh HY, Lee EJ, Yoon S, Chung BH, Cho KS, Hong SJ
Prostate. 2007
PubMed ID: 17469127
Akt is a key modulator of endothelial progenitor cell trafficking in ischemic muscle.
Hur J, Yoon CH, Lee CS, Kim TY, Oh IY, Park KW, Kim JH, Lee HS, Kang HJ, Chae IH, Oh BH, Park YB, Kim HS
Stem Cells. 2007
PubMed ID: 17412896
Association analysis of AKT1 and schizophrenia in a UK case control sample.
Norton N, Williams HJ, Dwyer S, Carroll L, Peirce T, Moskvina V, Segurado R, Nikolov I, Williams NM, Ikeda M, Iwata N, Owen MJ, O'Donovan MC
Schizophr Res. 2007
PubMed ID: 17383860
Nongenomic, endothelium-independent effects of estrogen on human coronary smooth muscle are mediated by type I (neuronal) NOS and PI3-kinase-Akt signaling.
Han G, Ma H, Chintala R, Miyake K, Fulton DJ, Barman SA, White RE
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17351066
Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs.
Miyahara T, Hamanaka K, Weber DS, Drake DA, Anghelescu M, Parker JC
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17322282
Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway.
Vogel C, Bauer A, Wiesnet M, Preissner KT, Schaper W, Marti HH, Fischer S
J Cell Physiol. 2007
PubMed ID: 17311300
Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.
Jin HO, An S, Lee HC, Woo SH, Seo SK, Choe TB, Yoo DH, Lee SB, Um HD, Lee SJ, Park MJ, Kim JI, Hong SI, Rhee CH, Park IC
Cell Signal. 2007
PubMed ID: 17307335
Reversine stimulates adipocyte differentiation and downregulates Akt and p70(s6k) signaling pathways in 3T3-L1 cells.
Kim YK, Choi HY, Kim NH, Lee W, Seo DW, Kang DW, Lee HY, Han JW, Park SW, Kim SN
Biochem Biophys Res Commun. 2007
PubMed ID: 17490611
Caspase-3-mediated cleavage of Akt: involvement of non-consensus sites and influence of phosphorylation.
Jahani-Asl A, Basak A, Tsang BK
FEBS Lett. 2007
PubMed ID: 17544405
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.
Li X, Monks B, Ge Q, Birnbaum MJ
Nature. 2007
PubMed ID: 17554339
AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation.
O'Shaughnessy RF, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C
J Biol Chem. 2007
PubMed ID: 17439945
Akt up- and down-regulation in response to endoplasmic reticulum stress.
Hosoi T, Hyoda K, Okuma Y, Nomura Y, Ozawa K
Brain Res. 2007
PubMed ID: 17434462
Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax.
Han Z, Hong L, Han Y, Wu K, Han S, Shen H, Li C, Yao L, Qiao T, Fan D
J Exp Clin Cancer Res. 2007
PubMed ID: 17725107
[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines]
Jiang YF, Zhao PW, Tan Y, Liu LH, Li MH, Matsuzaki Y, Niu JQ
Zhonghua Gan Zang Bing Za Zhi. 2007
PubMed ID: 17594810
Silencing of LMP1 induces cell cycle arrest and enhances chemosensitivity through inhibition of AKT signaling pathway in EBV-positive nasopharyngeal carcinoma cells.
Mei YP, Zhou JM, Wang Y, Huang H, Deng R, Feng GK, Zeng YX, Zhu XF
Cell Cycle. 2007
PubMed ID: 17507800
Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.
Pathak SK, Basu S, Basu KK, Banerjee A, Pathak S, Bhattacharyya A, Kaisho T, Kundu M, Basu J
Nat Immunol. 2007
PubMed ID: 17486091
Enhanced activity of the myocardial Na+/H+ exchanger contributes to left ventricular hypertrophy in the Goto-Kakizaki rat model of type 2 diabetes: critical role of Akt.
Darmellah A, Baetz D, Prunier F, Tamareille S, Rücker-Martin C, Feuvray D
Diabetologia. 2007
PubMed ID: 17429605
Regulation of scavenger receptor class BI gene expression by angiotensin II in vascular endothelial cells.
Yu X, Murao K, Imachi H, Cao WM, Li J, Matsumoto K, Nishiuchi T, Ahmed RA, Wong NC, Kosaka H, Unterman TG, Ishida T
Hypertension. 2007
PubMed ID: 17404186
A role for Akt in epidermal growth factor-stimulated cell cycle progression in cultured hepatocytes: generation of a hyperproliferative window after adenoviral expression of constitutively active Akt.
Luo Y, Dixon CJ, Hall JF, White PJ, Boarder MR
J Pharmacol Exp Ther. 2007
PubMed ID: 17371807
Activity of the Akt-dependent anabolic and catabolic pathways in muscle and liver samples in cancer-related cachexia.
Schmitt TL, Martignoni ME, Bachmann J, Fechtner K, Friess H, Kinscherf R, Hildebrandt W
J Mol Med. 2007
PubMed ID: 17333095
Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord.
Hayakawa-Yano Y, Nishida K, Fukami S, Gotoh Y, Hirano T, Nakagawa T, Shimazaki T, Okano H
Stem Cells. 2007
PubMed ID: 17332510
Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells.
Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME
Endocrinology. 2007
PubMed ID: 17332061
FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway.
Thamilselvan V, Craig DH, Basson MD
FASEB J. 2007
PubMed ID: 17317726
PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK
Mol Cell Biochem. 2007
PubMed ID: 17235455
Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events.
Parhar K, Eivemark S, Assi K, Gómez-Muñoz A, Yee A, Salh B
Mol Cell Biochem. 2007
PubMed ID: 17136479
Real-time imaging nuclear translocation of Akt1 in HCC cells.
Zhu L, Hu C, Li J, Xue P, He X, Ge C, Qin W, Yao G, Gu J
Biochem Biophys Res Commun. 2007
PubMed ID: 17400190
Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.
Hinton CV, Fitzgerald LD, Thompson ME
Exp Cell Res. 2007
PubMed ID: 17428466
Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells.
Xu J, Gao M, Fan S, Meng Q, Goldberg ID, Abounader R, Ressom H, Laterra JJ, Rosen EM
Oncogene. 2007
PubMed ID: 17099727
[Effects of AKT protein kinase activation on biologic behavior of diffuse large B cell lymphoma cells]
Zhang TC, Zhou XY, Yu BH, Zhang TM, Shi DR
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 17706139
[The effect of protein kinase B on the expression and location of p21 in early development of mouse fertilized eggs]
Wu DD, Feng C, Liu Y, Zhang J, Zong ZH, Ju YH, Li XS, Yu BZ
Sheng Wu Gong Cheng Xue Bao. 2007
PubMed ID: 17578000
CXCR4 expression is associated with pelvic lymph node metastasis in cervical adenocarcinoma.
Yang YC, Lee ZY, Wu CC, Chen TC, Chang CL, Chen CP
Int J Gynecol Cancer. 2007
PubMed ID: 17504381
Correlation between EGFR gene mutation pattern and Akt phosphorylation in pulmonary adenocarcinomas.
Ikeda S, Takabe K, Inagaki M, Funakoshi N, Suzuki K, Shibata T
Pathol Int. 2007
PubMed ID: 17493174
Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors.
Kurmasheva RT, Harwood FC, Houghton PJ
Mol Cancer Ther. 2007
PubMed ID: 17483438
Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner.
Moumen A, Ieraci A, Patané S, Solé C, Comella JX, Dono R, Maina F
Hepatology. 2007
PubMed ID: 17464994
Akt1 governs breast cancer progression in vivo.
Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17460049
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.
Mao C, Tili EG, Dose M, Haks MC, Bear SE, Maroulakou I, Horie K, Gaitanaris GA, Fidanza V, Ludwig T, Wiest DL, Gounari F, Tsichlis PN
J Immunol. 2007
PubMed ID: 17442925
Akt mediates self-renewal division of mouse spermatogonial stem cells.
Lee J, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, Toyokuni S, Kimura T, Nakano T, Ogura A, Shinohara T
Development. 2007
PubMed ID: 17428826
Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo.
Zhong J, Li X, McNamee C, Chen AP, Baccarini M, Snider WD
Nat Neurosci. 2007
PubMed ID: 17396120
Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
Metzger DE, Xu Y, Shannon JM
Dev Dyn. 2007
PubMed ID: 17394208
Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle.
Smith IJ, Dodd SL
Exp Physiol. 2007
PubMed ID: 17272355
Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: role of protein kinase Czeta and phosphatase.
Dey R, Majumder N, Bhattacharjee S, Majumdar SB, Banerjee R, Ganguly S, Das P, Majumdar S
Infect Immun. 2007
PubMed ID: 17220321
Phosphorylation of the survival kinase Akt by superoxide is dependent on an ascorbate-reversible oxidation of PTEN.
Lim S, Clément MV
Free Radic Biol Med. 2007
PubMed ID: 17382199
AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.
Oyama K, Okawa T, Nakagawa H, Takaoka M, Andl CD, Kim SH, Klein-Szanto A, Diehl JA, Herlyn M, El-Deiry W, Rustgi AK
Oncogene. 2007
PubMed ID: 17043653
AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells.
Frost P, Shi Y, Hoang B, Lichtenstein A
Oncogene. 2007
PubMed ID: 17016437
Different regulation of p27 and Akt during cardiomyocyte proliferation and hypertrophy.
Hinrichsen R, Haunsø S, Busk PK
Growth Factors. 2007
PubMed ID: 17852410
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, Hemmings BA, Downward J, Parker PJ, Larijani B
PLoS Biol. 2007
PubMed ID: 17407381
The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts.
Onishi K, Higuchi M, Asakura T, Masuyama N, Gotoh Y
Genes Cells. 2007
PubMed ID: 17397400
High expression of several tyrosine kinases and activation of the PI3K/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma.
Renné C, Willenbrock K, Martin-Subero JI, Hinsch N, Döring C, Tiacci E, Klapper W, Möller P, Küppers R, Hansmann ML, Siebert R, Bräuninger A
Leukemia. 2007
PubMed ID: 17375124
PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr.
Xie C, Patel R, Wu T, Zhu J, Henry T, Bhaskarabhatla M, Samudrala R, Tus K, Gong Y, Zhou H, Wakeland EK, Zhou XJ, Mohan C
Int Immunol. 2007
PubMed ID: 17369192
HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation.
Akl H, Badran BM, Zein NE, Bex F, Sotiriou C, Willard-Gallo KE, Burny A, Martiat P
Leukemia. 2007
PubMed ID: 17287851
Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells.
Matthews JA, Belof JL, Acevedo-Duncan M, Potter RL
Mol Cell Biochem. 2007
PubMed ID: 17136481
Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ
Cell Signal. 2007
PubMed ID: 17113264
The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt.
Ogunwobi OO, Beales IL
Int J Colorectal Dis. 2007
PubMed ID: 16912864
The Par6alpha/aPKC complex regulates Akt1 activity by phosphorylating Thr34 in the PH-domain.
Weyrich P, Neuscheler D, Melzer M, Hennige AM, Häring HU, Lammers R
Mol Cell Endocrinol. 2007
PubMed ID: 17335965
Overexpression of HMGA1 promotes anoikis resistance and constitutive Akt activation in pancreatic adenocarcinoma cells.
Liau SS, Jazag A, Ito K, Whang EE
Br J Cancer. 2007
PubMed ID: 17342093
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J, Sierecki E, Gao T, Newton AC
Mol Cell. 2007
PubMed ID: 17386267
Differential activation of CREB by Akt1 and Akt2.
Kato S, Ding J, Du K
Biochem Biophys Res Commun. 2007
PubMed ID: 17276404
Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.
Takai S, Tokuda H, Hanai Y, Kozawa O
Mol Cell Endocrinol. 2007
PubMed ID: 17215071
Roles of the MEK1/2 and AKT pathways in CXCL12/CXCR4 induced cholangiocarcinoma cell invasion.
Leelawat K, Leelawat S, Narong S, Hongeng S
World J Gastroenterol. 2007
PubMed ID: 17461449
AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.
Bogush A, Pedrini S, Pelta-Heller J, Chan T, Yang Q, Mao Z, Sluzas E, Gieringer T, Ehrlich ME
J Biol Chem. 2007
PubMed ID: 17209049
Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.
Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, Hori M
EMBO J. 2007
PubMed ID: 17318185
Quantitative analysis of Akt phosphorylation and activity in response to EGF and insulin treatment.
Kumar N, Afeyan R, Sheppard S, Harms B, Lauffenburger DA
Biochem Biophys Res Commun. 2007
PubMed ID: 17214972
Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage.
Kang SG, Brown AL, Chung JH
J Biol Chem. 2007
PubMed ID: 17179152
Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.
Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA
Nat Med. 2007
PubMed ID: 17322895
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
Govindarajan B, Sligh JE, Vincent BJ, Li M, Canter JA, Nickoloff BJ, Rodenburg RJ, Smeitink JA, Oberley L, Zhang Y, Slingerland J, Arnold RS, Lambeth JD, Cohen C, Hilenski L, Griendling K, Martínez-Diez M, Cuezva JM, Arbiser JL
J Clin Invest. 2007
PubMed ID: 17318262
The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland.
Turunen JA, Peltonen JO, Pietiläinen OP, Hennah W, Loukola A, Paunio T, Silander K, Ekelund J, Varilo T, Partonen T, Lönnqvist J, Peltonen L
Schizophr Res. 2007
PubMed ID: 17300918
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.
Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ
J Clin Invest. 2007
PubMed ID: 17290308
Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation.
Yin W, Signore AP, Iwai M, Cao G, Gao Y, Johnnides MJ, Hickey RW, Chen J
Stroke. 2007
PubMed ID: 17272774
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.
Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T, Martinelli G, Conte R, Cocco L, McCubrey JA, Martelli AM
Leukemia. 2007
PubMed ID: 17215852
Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1.
Cao Z, Wu X, Yen L, Sweeney C, Carraway KL
Mol Cell Biol. 2007
PubMed ID: 17210635
Fibroblast growth factor receptor 3 kinase domain mutation increases cortical progenitor proliferation via mitogen-activated protein kinase activation.
Thomson RE, Pellicano F, Iwata T
J Neurochem. 2007
PubMed ID: 17181553
Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity.
Raghavendra PB, Sreenivasan Y, Manna SK
Mol Immunol. 2007
PubMed ID: 17173971
M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.
Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G
J Virol. 2007
PubMed ID: 17151107
Inhibition of Flt3-activating mutations does not prevent constitutive activation of ERK/Akt/STAT pathways in some AML cells: a possible cause for the limited effectiveness of monotherapy with small-molecule inhibitors.
Siendones E, Barbarroja N, Torres LA, Buendía P, Velasco F, Dorado G, Torres A, López-Pedrera C
Hematol Oncol. 2007
PubMed ID: 17128418
Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells.
Fang J, Zhou Q, Shi XL, Jiang BH
Carcinogenesis. 2007
PubMed ID: 17065200
Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer.
Blanco-Aparicio C, Pérez-Gallego L, Pequeño B, Leal JF, Renner O, Carnero A
Carcinogenesis. 2007
PubMed ID: 17050554
Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activation.
Scott GA, Arioka M, Jacobs SE
J Invest Dermatol. 2007
PubMed ID: 17024099
Differential role of PI3K/Akt pathway in the infarct size limitation and antiarrhythmic protection in the rat heart.
Ravingerová T, Matejíková J, Neckár J, Andelová E, Kolár F
Mol Cell Biochem. 2007
PubMed ID: 17016676
Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma.
Tokunaga E, Oki E, Kimura Y, Yamanaka T, Egashira A, Nishida K, Koga T, Morita M, Kakeji Y, Maehara Y
Breast Cancer Res Treat. 2007
PubMed ID: 17006756
AKT in thyroid tumorigenesis and progression.
Shinohara M, Chung YJ, Saji M, Ringel MD
Endocrinology. 2007
PubMed ID: 16946008
Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer.
Hou P, Liu D, Shan Y, Hu S, Studeman K, Condouris S, Wang Y, Trink A, El-Naggar AK, Tallini G, Vasko V, Xing M
Clin Cancer Res. 2007
PubMed ID: 17317825
Lifelong accumulation of bone in mice lacking Pten in osteoblasts.
Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere MC, Bouxsein ML, Wan C, Williams BO, Clemens TL
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287359
Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.
Chugh P, Fan S, Planelles V, Maggirwar SB, Dewhurst S, Kim B
J Mol Biol. 2007
PubMed ID: 17157319
Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.
Wu C, Huang J
J Biol Chem. 2007
PubMed ID: 17148458
Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis.
Cao L, Cao DX, Su XW, Chen LJ, Liu AL, Jian WJ, Wu YP, Qiu PX, Yan GM
Acta Pharmacol Sin. 2007
PubMed ID: 17241518
Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia.
Ikeda M, Ozaki N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Kishi T, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Iwata N
Genes Brain Behav. 2007
PubMed ID: 17233643
Marked suppression of tumor growth by FTY720 in a rat liver tumor model: the significance of down-regulation of cell survival Akt pathway.
Ng KT, Man K, Ho JW, Sun CK, Lee TK, Zhao Y, Lo CM, Poon RT, Fan ST
Int J Oncol. 2007
PubMed ID: 17203219
Expression of PTEN and Akt phosphorylation in lipopolysaccharide-treated NIH3T3 cells.
Okamura H, Yoshida K, Sasaki E, Qiu L, Amorim BR, Morimoto H, Haneji T
Cell Biol Int. 2007
PubMed ID: 17081778
AKT delays the early-activated apoptotic pathway in UVB-irradiated keratinocytes via BAD translocation.
Claerhout S, Decraene D, Van Laethem A, Van Kelst S, Agostinis P, Garmyn M
J Invest Dermatol. 2007
PubMed ID: 16932738
Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress.
Chang R, Wang E
J Cell Biochem. 2007
PubMed ID: 16888816
HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection.
Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA
Cell Death Differ. 2007
PubMed ID: 16841089
Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.
Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17251350
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Akt regulates nuclear/cytoplasmic localization of tuberin.
Rosner M, Freilinger A, Hengstschläger M
Oncogene. 2007
PubMed ID: 16862180
Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells.
D'Alimonte I, Flati V, D'Auro M, Toniato E, Martinotti S, Rathbone MP, Jiang S, Ballerini P, Di Iorio P, Caciagli F, Ciccarelli R
J Immunol. 2007
PubMed ID: 17202332
Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3beta signaling.
Min YK, Lee JE, Chung KC
Exp Cell Res. 2007
PubMed ID: 17098228
Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death.
Li G, Anderson RE, Tomita H, Adler R, Liu X, Zack DJ, Rajala RV
J Neurosci. 2007
PubMed ID: 17202487
Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients.
Florena AM, Tripodo C, Guarnotta C, Ingrao S, Porcasi R, Martorana A, Lo Bosco G, Cabibi D, Franco V
Pathobiology. 2007
PubMed ID: 18087195
Akt1 in osteoblasts and osteoclasts controls bone remodeling.
Kawamura N, Kugimiya F, Oshima Y, Ohba S, Ikeda T, Saito T, Shinoda Y, Kawasaki Y, Ogata N, Hoshi K, Akiyama T, Chen WS, Hay N, Tobe K, Kadowaki T, Azuma Y, Tanaka S, Nakamura K, Chung UI, Kawaguchi H
PLoS ONE. 2007
PubMed ID: 17957242
Deletion of PKBalpha/Akt1 affects thymic development.
Fayard E, Gill J, Paolino M, Hynx D, Holländer GA, Hemmings BA
PLoS ONE. 2007
PubMed ID: 17912369
Could changes in the regulation of the PI3K/PKB/Akt signaling pathway and cell cycle be involved in astrocytic tumor pathogenesis and progression?
Hlobilkova A, Ehrmann J, Sedlakova E, Krejci V, Knizetova P, Fiuraskova M, Kala M, Kalita O, Kolar Z
Neoplasma. 2007
PubMed ID: 17822324
Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling.
Ruggiero T, Trabucchi M, Ponassi M, Corte G, Chen CY, al-Haj L, Khabar KS, Briata P, Gherzi R
BMC Mol Biol. 2007
PubMed ID: 17437629
Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens.
Xie L, Chen H, Overbeek PA, Reneker LW
Mol Vis. 2007
PubMed ID: 17417601
Role of receptor and nonreceptor protein tyrosine kinases in H2O2-induced PKB and ERK1/2 signaling.
Mehdi MZ, Azar ZM, Srivastava AK
Cell Biochem Biophys. 2007
PubMed ID: 17406055
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN
Cancer Res. 2007
PubMed ID: 17210696
Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of beta1-integrin and phosphatidylinositol 3-kinase/Akt.
Wang HQ, Bai L, Shen BR, Yan ZQ, Jiang ZL
Eur J Cell Biol. 2007
PubMed ID: 17141917
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma.
Tsurutani J, Steinberg SM, Ballas M, Robertson M, LoPiccolo J, Soda H, Kohno S, Egilsson V, Dennis PA
Lung Cancer. 2007
PubMed ID: 17097759
Proteomics exploration reveals that actin is a signaling target of the kinase Akt.
Vandermoere F, El Yazidi-Belkoura I, Demont Y, Slomianny C, Antol J, Lemoine J, Hondermarck H
Mol Cell Proteomics. 2007
PubMed ID: 17088265
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.
Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC
Mol Cell Biol. 2007
PubMed ID: 17060455
Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.
Cleasby ME, Reinten TA, Cooney GJ, James DE, Kraegen EW
Mol Endocrinol. 2007
PubMed ID: 17021050
The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival.
Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani S, Sen CK, Marsh CB
Am J Respir Cell Mol Biol. 2007
PubMed ID: 16931806
Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.
Sharrard RM, Maitland NJ
Cell Signal. 2007
PubMed ID: 16842970
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of AKT1/PKBalpha.
Kiessling S, Lutz-Nicoladoni C, Olsson A, Niederegger H, Harald N, Baier G, Villunger A
Cell Death Differ. 2007
PubMed ID: 16778831
YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation.
Uchiumi T, Fotovati A, Sasaguri T, Shibahara K, Shimada T, Fukuda T, Nakamura T, Izumi H, Tsuzuki T, Kuwano M, Kohno K
J Biol Chem. 2006
PubMed ID: 17082189
Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2.
Zhande R, Zhang W, Zheng Y, Pendleton E, Li Y, Polakiewicz RD, Sun XJ
J Biol Chem. 2006
PubMed ID: 17068339
SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27.
Zhou P, Kitaura H, Teitelbaum SL, Krystal G, Ross FP, Takeshita S
J Immunol. 2006
PubMed ID: 17142780
Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.
Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, Conti M
EMBO J. 2006
PubMed ID: 17124499
Reversal of multidrug resistance of gastric cancer cells by downregulation of Akt1 with Akt1 siRNA.
Han Z, Hong L, Wu K, Han S, Shen H, Liu C, Han Y, Liu Z, Han Y, Fan D
J Exp Clin Cancer Res. 2006
PubMed ID: 17310852
Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9.
Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L
Appl Biochem Biotechnol. 2006
PubMed ID: 17299206
Downregulation of VEGF-A, STAT5 and AKT in acute myeloid leukemia blasts of patients treated with SU5416.
Loges S, Tinnefeld H, Metzner A, Jücker M, Butzal M, Bruweleit M, Fischer U, Draab E, Schuch G, O'-Farrel AM, Hossfeld DK, Bokemeyer C, Fiedler W
Leuk Lymphoma. 2006
PubMed ID: 17169805
An essential role for Akt1 in dendritic cell function and tumor immunotherapy.
Park D, Lapteva N, Seethammagari M, Slawin KM, Spencer DM
Nat Biotechnol. 2006
PubMed ID: 17143278
Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.
Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA
Cell Metab. 2006
PubMed ID: 17141631
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM
Dev Cell. 2006
PubMed ID: 17141160
Akt-mediated GSK-3beta inhibition prevents migration of polyamine-depleted intestinal epithelial cells via Rac1.
Vaidya RJ, Ray RM, Johnson LR
Cell Mol Life Sci. 2006
PubMed ID: 17109063
Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats.
Wang R, Zhang QG, Han D, Xu J, Lü Q, Zhang GY
J Neurochem. 2006
PubMed ID: 17064355
MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27.
Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H, Shen X
J Biol Chem. 2006
PubMed ID: 17015449
Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasias.
Schick V, Majores M, Engels G, Spitoni S, Koch A, Elger CE, Simon M, Knobbe C, Blümcke I, Becker AJ
Acta Neuropathol. 2006
PubMed ID: 17013611
Ultraviolet B-induced matrix metalloproteinase-1 and -3 secretions are mediated via PTEN/Akt pathway in human dermal fibroblasts.
Oh JH, Kim A, Park JM, Kim SH, Chung AS
J Cell Physiol. 2006
PubMed ID: 16972255
ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways.
Heo JS, Han HJ
Stem Cells. 2006
PubMed ID: 16916926
AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells.
Lee JH, Ragolia L
Am J Physiol Cell Physiol. 2006
PubMed ID: 16855220
Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway.
Meng Q, Xia C, Fang J, Rojanasakul Y, Jiang BH
Cell Signal. 2006
PubMed ID: 16839745
The immunomodulator AS101 induces growth arrest and apoptosis in multiple myeloma: association with the Akt/survivin pathway.
Hayun M, Naor Y, Weil M, Albeck M, Peled A, Don J, Haran-Ghera N, Sredni B
Biochem Pharmacol. 2006
PubMed ID: 16889755
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration.
Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J
J Biol Chem. 2006
PubMed ID: 17012749
Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related phosphatidylinositol 3-kinase/Akt and beta-catenin/T-cell factor-dependent pathway in human endothelial cells.
Leung KW, Pon YL, Wong RN, Wong AS
J Biol Chem. 2006
PubMed ID: 17008323
The IL sequence in the LLKIL motif in CXCR2 is required for full ligand-induced activation of Erk, Akt, and chemotaxis in HL60 cells.
Sai J, Walker G, Wikswo J, Richmond A
J Biol Chem. 2006
PubMed ID: 16990258
Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas.
Van Meter TE, Broaddus WC, Cash D, Fillmore H
Cancer. 2006
PubMed ID: 17041888
Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning.
Lai WS, Xu B, Westphal KG, Paterlini M, Olivier B, Pavlidis P, Karayiorgou M, Gogos JA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17077150
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.
Héron-Milhavet L, Franckhauser C, Rana V, Berthenet C, Fisher D, Hemmings BA, Fernandez A, Lamb NJ
Mol Cell Biol. 2006
PubMed ID: 16982699
Pyruvate protects cerebellar granular cells from 6-hydroxydopamine-induced cytotoxicity by activating the Akt signaling pathway and increasing glutathione peroxidase expression.
Fernandez-Gomez FJ, Pastor MD, Garcia-Martinez EM, Melero-Fernandez de Mera R, Gou-Fabregas M, Gomez-Lazaro M, Calvo S, Soler RM, Galindo MF, Jordán J
Neurobiol Dis. 2006
PubMed ID: 16978869
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ
Mol Cell Biol. 2006
PubMed ID: 16966378
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies.
Dummler B, Tschopp O, Hynx D, Yang ZZ, Dirnhofer S, Hemmings BA
Mol Cell Biol. 2006
PubMed ID: 16923958
Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
Léger B, Cartoni R, Praz M, Lamon S, Dériaz O, Crettenand A, Gobelet C, Rohmer P, Konzelmann M, Luthi F, Russell AP
J Physiol. 2006
PubMed ID: 16916907
P-Akt expression distinguishes two types of malignant rhabdoid tumors.
Charboneau A, Chai J, Jordan J, Funkhouser W, Judkins A, Biegel J, Weissman B
J Cell Physiol. 2006
PubMed ID: 16897758
Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.
Rafiee P, Theriot ME, Nelson VM, Heidemann J, Kanaa Y, Horowitz SA, Rogaczewski A, Johnson CP, Ali I, Shaker R, Binion DG
Am J Physiol Cell Physiol. 2006
PubMed ID: 16790501
PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells.
Burdick AD, Ivnitski-Steele ID, Lauer FT, Burchiel SW
Carcinogenesis. 2006
PubMed ID: 16774943
Elevated inorganic phosphate stimulates Akt-ERK1/2-Mnk1 signaling in human lung cells.
Chang SH, Yu KN, Lee YS, An GH, Beck GR, Colburn NH, Lee KH, Cho MH
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16763222
Akt2 regulates cardiac metabolism and cardiomyocyte survival.
DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ
J Biol Chem. 2006
PubMed ID: 16950770
S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.
Zhang HH, Lipovsky AI, Dibble CC, Sahin M, Manning BD
Mol Cell. 2006
PubMed ID: 17052453
Akt phosphorylation is essential for nuclear translocation and retention in NGF-stimulated PC12 cells.
Xuan Nguyen TL, Choi JW, Lee SB, Ye K, Woo SD, Lee KH, Ahn JY
Biochem Biophys Res Commun. 2006
PubMed ID: 16956580
Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65.
Liu Y, Denlinger CE, Rundall BK, Smith PW, Jones DR
J Biol Chem. 2006
PubMed ID: 16926151
Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.
Liu X, Shi Y, Birnbaum MJ, Ye K, De Jong R, Oltersdorf T, Giranda VL, Luo Y
J Biol Chem. 2006
PubMed ID: 16923802
Regulation of TopBP1 oligomerization by Akt/PKB for cell survival.
Liu K, Paik JC, Wang B, Lin FT, Lin WC
EMBO J. 2006
PubMed ID: 17006541
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity.
Yang Q, Inoki K, Ikenoue T, Guan KL
Genes Dev. 2006
PubMed ID: 17043309
Cutting edge: abortive proliferation of CD46-induced Tr1-like cells due to a defective Akt/Survivin signaling pathway.
Meiffren G, Flacher M, Azocar O, Rabourdin-Combe C, Faure M
J Immunol. 2006
PubMed ID: 17015676
Ras signaling is essential for lens cell proliferation and lens growth during development.
Xie L, Overbeek PA, Reneker LW
Dev Biol. 2006
PubMed ID: 16889766
Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure.
Schiekofer S, Shiojima I, Sato K, Galasso G, Oshima Y, Walsh K
Physiol Genomics. 2006
PubMed ID: 16882883
Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.
Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL
J Cell Biol. 2006
PubMed ID: 17015619
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B
Cell. 2006
PubMed ID: 16962653
Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas.
Gort EH, Groot AJ, Derks van de Ven TL, van der Groep P, Verlaan I, van Laar T, van Diest PJ, van der Wall E, Shvarts A
Oncogene. 2006
PubMed ID: 16682946
Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.
Zhu D, Hattori H, Jo H, Jia Y, Subramanian KK, Loison F, You J, Le Y, Honczarenko M, Silberstein L, Luo HR
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16988010
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.
Skeen JE, Bhaskar PT, Chen CC, Chen WS, Peng XD, Nogueira V, Hahn-Windgassen A, Kiyokawa H, Hay N
Cancer Cell. 2006
PubMed ID: 17045205
Failure to support a genetic contribution of AKT1 polymorphisms and altered AKT signaling in schizophrenia.
Ide M, Ohnishi T, Murayama M, Matsumoto I, Yamada K, Iwayama Y, Dedova I, Toyota T, Asada T, Takashima A, Yoshikawa T
J Neurochem. 2006
PubMed ID: 16987250
An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway.
Vatinel S, Ferrand A, Lopez F, Kowalski-Chauvel A, Estève JP, Fourmy D, Dufresne M, Seva C
Biochim Biophys Acta. 2006
PubMed ID: 16963136
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability.
Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA
Dev Cell. 2006
PubMed ID: 16962829
Atrophy-related ubiquitin ligases, atrogin-1 and MuRF1 are up-regulated in aged rat Tibialis Anterior muscle.
Clavel S, Coldefy AS, Kurkdjian E, Salles J, Margaritis I, Derijard B
Mech Ageing Dev. 2006
PubMed ID: 16949134
Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane.
Gonzalez E, McGraw TE
Mol Biol Cell. 2006
PubMed ID: 16914513
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
Fritzius T, Burkard G, Haas E, Heinrich J, Schweneker M, Bosse M, Zimmermann S, Frey AD, Caelers A, Bachmann AS, Moelling K
Biochem J. 2006
PubMed ID: 16792529
Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression.
Xia C, Meng Q, Cao Z, Shi X, Jiang BH
J Cell Physiol. 2006
PubMed ID: 16775835
Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K/Akt-NF-kappaB signaling pathway.
Tong Q, Zheng L, Lin L, Li B, Wang D, Li D
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16709959
AKT can be activated in the nucleus.
Wang R, Brattain MG
Cell Signal. 2006
PubMed ID: 16616456
Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells.
Hillion JA, Li Y, Maric D, Takanohashi A, Klimanis D, Barker JL, Hallenbeck JM
J Cereb Blood Flow Metab. 2006
PubMed ID: 16511503
Involvement of insulin-like growth factor type 1 receptor and protein kinase Cdelta in bis(maltolato)oxovanadium(IV)-induced phosphorylation of protein kinase B in HepG2 cells.
Mehdi MZ, Vardatsikos G, Pandey SK, Srivastava AK
Biochemistry. 2006
PubMed ID: 16981720
Combinatorial activities of Akt and B-Raf/Erk signaling in a mouse model of androgen-independent prostate cancer.
Gao H, Ouyang X, Banach-Petrosky WA, Gerald WL, Shen MM, Abate-Shen C
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16973750
Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5.
Su X, Lodhi IJ, Saltiel AR, Stahl PD
J Biol Chem. 2006
PubMed ID: 16880210
Rapid nongenomic actions of thyroid hormone.
Hiroi Y, Kim HH, Ying H, Furuya F, Huang Z, Simoncini T, Noma K, Ueki K, Nguyen NH, Scanlan TS, Moskowitz MA, Cheng SY, Liao JK
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16966610
Neutrophil signaling pathways activated by bacterial DNA stimulation.
Alvarez ME, Fuxman Bass JI, Geffner JR, Calotti PX, Costas M, Coso OA, Gamberale R, Vermeulen ME, Salamone G, Martinez D, Tanos T, Trevani AS
J Immunol. 2006
PubMed ID: 16951367
Lithium-induced activation of Akt and CaM kinase II contributes to its neuroprotective action in a rat microsphere embolism model.
Sasaki T, Han F, Shioda N, Moriguchi S, Kasahara J, Ishiguro K, Fukunaga K
Brain Res. 2006
PubMed ID: 16843447
Molecular pathways leading to oxidative stress-induced phosphorylation of Akt.
Lahair MM, Howe CJ, Rodriguez-Mora O, McCubrey JA, Franklin RA
Antioxid Redox Signal. 2006
PubMed ID: 16987028
Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.
Takai S, Tokuda H, Hanai Y, Kozawa O
Horm Metab Res. 2006
PubMed ID: 16981137
Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways.
Park CM, Park MJ, Kwak HJ, Lee HC, Kim MS, Lee SH, Park IC, Rhee CH, Hong SI
Cancer Res. 2006
PubMed ID: 16951163
AKT regulation of estrogen receptor beta transcriptional activity in breast cancer.
Duong BN, Elliott S, Frigo DE, Melnik LI, Vanhoy L, Tomchuck S, Lebeau HP, David O, Beckman BS, Alam J, Bratton MR, McLachlan JA, Burow ME
Cancer Res. 2006
PubMed ID: 16951146
An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells.
Calmont A, Wandzioch E, Tremblay KD, Minowada G, Kaestner KH, Martin GR, Zaret KS
Dev Cell. 2006
PubMed ID: 16950125
pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model.
Bhaskara VK, Sundaram C, Babu PP
Neurochem Res. 2006
PubMed ID: 16944316
Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT.
Brunt KR, Fenrich KK, Kiani G, Tse MY, Pang SC, Ward CA, Melo LG
Arterioscler Thromb Vasc Biol. 2006
PubMed ID: 16840713
Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.
Gervais M, Dugourd C, Muller L, Ardidie C, Canton B, Loviconi L, Corvol P, Chneiweiss H, Monnot C
Mol Biol Cell. 2006
PubMed ID: 16822839
Akt1 suppresses radiation-induced germ cell apoptosis in vivo.
Rasoulpour T, DiPalma K, Kolvek B, Hixon M
Endocrinology. 2006
PubMed ID: 16763066
Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch.
Dogra C, Changotra H, Wergedal JE, Kumar A
J Cell Physiol. 2006
PubMed ID: 16741926
Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt.
Plante I, Charbonneau M, Cyr DG
Carcinogenesis. 2006
PubMed ID: 16679308
Down-regulation of the tumor suppressor gene retinoic acid receptor beta2 through the phosphoinositide 3-kinase/Akt signaling pathway.
Lefebvre B, Brand C, Flajollet S, Lefebvre P
Mol Endocrinol. 2006
PubMed ID: 16613989
Effects of Akt on cardiac myocytes: location counts.
Catalucci D, Condorelli G
Circ Res. 2006
PubMed ID: 16917099
Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population.
Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA
Circ Res. 2006
PubMed ID: 16840722
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
Lu D, Huang J, Basu A
J Biol Chem. 2006
PubMed ID: 16785234
Nuclear targeting of Akt antagonizes aspects of cardiomyocyte hypertrophy.
Tsujita Y, Muraski J, Shiraishi I, Kato T, Kajstura J, Anversa P, Sussman MA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16882732
Members of the hSWI/SNF chromatin remodeling complex associate with and are phosphorylated by protein kinase B/Akt.
Foster KS, McCrary WJ, Ross JS, Wright CF
Oncogene. 2006
PubMed ID: 16568092
Negative cell cycle regulator 14-3-3sigma stabilizes p27 Kip1 by inhibiting the activity of PKB/Akt.
Yang H, Zhang Y, Zhao R, Wen YY, Fournier K, Wu HB, Yang HY, Diaz J, Laronga C, Lee MH
Oncogene. 2006
PubMed ID: 16532026
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.
Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, Sessa WC, Dvorak HF, Benjamin LE
Cancer Cell. 2006
PubMed ID: 16904613
Anaphylactic shock depends on PI3K and eNOS-derived NO.
Cauwels A, Janssen B, Buys E, Sips P, Brouckaert P
J Clin Invest. 2006
PubMed ID: 16886062
Effects of GM-CSF and M-CSF on tumor progression of lung cancer: roles of MEK1/ERK and AKT/PKB pathways.
Uemura Y, Kobayashi M, Nakata H, Kubota T, Bandobashi K, Saito T, Taguchi H
Int J Mol Med. 2006
PubMed ID: 16820947
Cbl and Akt regulate CXCL8-induced and CXCR1- and CXCR2-mediated chemotaxis.
Lane HC, Anand AR, Ganju RK
Int Immunol. 2006
PubMed ID: 16798838
Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway.
Peter AK, Crosbie RH
Exp Cell Res. 2006
PubMed ID: 16797529
Akt/GSK3beta survival signaling is involved in acute brain injury after subarachnoid hemorrhage in rats.
Endo H, Nito C, Kamada H, Yu F, Chan PH
Stroke. 2006
PubMed ID: 16794215
Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1).
Crean JK, Furlong F, Mitchell D, McArdle E, Godson C, Martin F
FASEB J. 2006
PubMed ID: 16790529
LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway.
Wu M, Huang C, Gan K, Huang H, Chen Q, Ouyang J, Tang Y, Li X, Yang Y, Zhou H, Zhou Y, Zeng Z, Xiao L, Li D, Tang K, Shen S, Li G
Mol Biol Cell. 2006
PubMed ID: 16723503
Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells.
Lien SC, Usami S, Chien S, Chiu JJ
Cell Signal. 2006
PubMed ID: 16310342
Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity.
Yan D, Guo L, Wang Y
J Cell Biol. 2006
PubMed ID: 16864652
Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways.
Kenessey A, Ojamaa K
J Biol Chem. 2006
PubMed ID: 16717100
Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.
Koga F, Xu W, Karpova TS, McNally JG, Baron R, Neckers L
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16844778
C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1.
Fosbrink M, Niculescu F, Rus V, Shin ML, Rus H
J Biol Chem. 2006
PubMed ID: 16670089
Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway.
Pore N, Jiang Z, Shu HK, Bernhard E, Kao GD, Maity A
Mol Cancer Res. 2006
PubMed ID: 16849522
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.
Pelloski CE, Lin E, Zhang L, Yung WK, Colman H, Liu JL, Woo SY, Heimberger AB, Suki D, Prados M, Chang S, Barker FG, Fuller GN, Aldape KD
Clin Cancer Res. 2006
PubMed ID: 16818690
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.
Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR
Cell Metab. 2006
PubMed ID: 16814735
Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells.
Otaegi G, Yusta-Boyo MJ, Vergaño-Vera E, Méndez-Gómez HR, Carrera AC, Abad JL, González M, de la Rosa EJ, Vicario-Abejón C, de Pablo F
J Cell Sci. 2006
PubMed ID: 16787946
Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats.
Zhang X, Chen Y, Ikonomovic MD, Nathaniel PD, Kochanek PM, Marion DW, DeKosky ST, Jenkins LW, Clark RS
J Cereb Blood Flow Metab. 2006
PubMed ID: 16234845
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.
Mochizuki T, Furuta S, Mitsushita J, Shang WH, Ito M, Yokoo Y, Yamaura M, Ishizone S, Nakayama J, Konagai A, Hirose K, Kiyosawa K, Kamata T
Oncogene. 2006
PubMed ID: 16532036
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation.
Stojanovic A, Marjanovic JA, Brovkovych VM, Peng X, Hay N, Skidgel RA, Du X
J Biol Chem. 2006
PubMed ID: 16613861
Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52.
Gustin JA, Korgaonkar CK, Pincheira R, Li Q, Donner DB
J Biol Chem. 2006
PubMed ID: 16613850
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Chen ML, Xu PZ, Peng XD, Chen WS, Guzman G, Yang X, Di Cristofano A, Pandolfi PP, Hay N
Genes Dev. 2006
PubMed ID: 16778075
Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia.
Urao N, Okigaki M, Yamada H, Aadachi Y, Matsuno K, Matsui A, Matsunaga S, Tateishi K, Nomura T, Takahashi T, Tatsumi T, Matsubara H
Circ Res. 2006
PubMed ID: 16645141
Complex regulation of human androgen receptor expression by Wnt signaling in prostate cancer cells.
Yang X, Chen MW, Terry S, Vacherot F, Bemis DL, Capodice J, Kitajewski J, de la Taille A, Benson MC, Guo Y, Buttyan R
Oncogene. 2006
PubMed ID: 16474850
Association of AKT1 haplotype with the risk of schizophrenia in Iranian population.
Bajestan SN, Sabouri AH, Nakamura M, Takashima H, Keikhaee MR, Behdani F, Fayyazi MR, Sargolzaee MR, Bajestan MN, Sabouri Z, Khayami E, Haghighi S, Hashemi SB, Eiraku N, Tufani H, Najmabadi H, Arimura K, Sano A, Osame M
Am J Med Genet B Neuropsychiatr Genet. 2006
PubMed ID: 16583435
[Influence of LY294002 on protein kinase B expression in salivary adenoid cystic carcinoma (SACC)-83 and SACC-LM cells]
Yang ML, Shen L, Sun CF
Zhonghua Kou Qiang Yi Xue Za Zhi. 2006
PubMed ID: 16836907
Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract.
Garcia GE, Nicole A, Bhaskaran S, Gupta A, Kyprianou N, Kumar AP
Neoplasia. 2006
PubMed ID: 16820098
Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat.
Horwood JM, Dufour F, Laroche S, Davis S
Eur J Neurosci. 2006
PubMed ID: 16820027
Functional role of phosphatidylinositol 3-kinase/Akt pathway on cell growth and lytic cycle of Epstein-Barr virus in the Burkitt's lymphoma cell line, P3HR-1.
Mori T, Sairenji T
Virus Genes. 2006
PubMed ID: 16732486
Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells.
Harrison EM, McNally SJ, Devey L, Garden OJ, Ross JA, Wigmore SJ
FEBS J. 2006
PubMed ID: 16704410
Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.
Ahmad N, Wang Y, Haider KH, Wang B, Pasha Z, Uzun O, Ashraf M
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16687609
The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.
Armstrong L, Hughes O, Yung S, Hyslop L, Stewart R, Wappler I, Peters H, Walter T, Stojkovic P, Evans J, Stojkovic M, Lako M
Hum Mol Genet. 2006
PubMed ID: 16644866
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Yang RZ, Lee MJ, Hu H, Pray J, Wu HB, Hansen BC, Shuldiner AR, Fried SK, McLenithan JC, Gong DW
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16531507
DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling.
Lu X, Kambe F, Cao X, Yoshida T, Ohmori S, Murakami K, Kaji T, Ishii T, Zadworny D, Seo H
Endocrinology. 2006
PubMed ID: 16513830
Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function.
Luque RM, Kineman RD
Endocrinology. 2006
PubMed ID: 16513828
Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth.
Doughty CA, Bleiman BF, Wagner DJ, Dufort FJ, Mataraza JM, Roberts MF, Chiles TC
Blood. 2006
PubMed ID: 16449529
Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity.
Soltys CL, Kovacic S, Dyck JR
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16428351
Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.
Gandy JC, Rountree AE, Bijur GN
FEBS Lett. 2006
PubMed ID: 16684529
Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy.
Serantes R, Arnalich F, Figueroa M, Salinas M, Andrés-Mateos E, Codoceo R, Renart J, Matute C, Cavada C, Cuadrado A, Montiel C
J Biol Chem. 2006
PubMed ID: 16567807
Identification of a tumour suppressor network opposing nuclear Akt function.
Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP
Nature. 2006
PubMed ID: 16680151
The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival.
Vandermoere F, El Yazidi-Belkoura I, Slomianny C, Demont Y, Bidaux G, Adriaenssens E, Lemoine J, Hondermarck H
J Biol Chem. 2006
PubMed ID: 16551632
Kinetic mechanism of AKT/PKB enzyme family.
Zhang X, Zhang S, Yamane H, Wahl R, Ali A, Lofgren JA, Kendall RL
J Biol Chem. 2006
PubMed ID: 16540465
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.
Han YH, Cao X, Lin B, Lin F, Kolluri SK, Stebbins J, Reed JC, Dawson MI, Zhang XK
Oncogene. 2006
PubMed ID: 16434970
Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase.
Ahn JY, Liu X, Liu Z, Pereira L, Cheng D, Peng J, Wade PA, Hamburger AW, Ye K
EMBO J. 2006
PubMed ID: 16642037
Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor.
Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16682621
PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib.
Ueda S, Basaki Y, Yoshie M, Ogawa K, Sakisaka S, Kuwano M, Ono M
Cancer Res. 2006
PubMed ID: 16707461
Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity.
Li X, Lu Y, Jin W, Liang K, Mills GB, Fan Z
J Biol Chem. 2006
PubMed ID: 16549426
Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.
Misra UK, Deedwania R, Pizzo SV
J Biol Chem. 2006
PubMed ID: 16543232
HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.
Anand AR, Ganju RK
J Biol Chem. 2006
PubMed ID: 16524887
Akt1 is required for physiological cardiac growth.
DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ
Circulation. 2006
PubMed ID: 16636172
Group I metabotropic receptor neuroprotection requires Akt and its substrates that govern FOXO3a, Bim, and beta-catenin during oxidative stress.
Chong ZZ, Li F, Maiese K
Curr Neurovasc Res. 2006
PubMed ID: 16719794
Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch.
Birukova AA, Chatchavalvanich S, Rios A, Kawkitinarong K, Garcia JG, Birukov KG
Am J Pathol. 2006
PubMed ID: 16651639
Ultraviolet radiation attenuates thrombospondin 1 expression via PI3K-Akt activation in human keratinocytes.
Kim MS, Oh YJ, Lee S, Kim JE, Kim KH, Chung JH
Photochem Photobiol. 2006
PubMed ID: 16478297
Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy.
Howes AL, Miyamoto S, Adams JW, Woodcock EA, Brown JH
J Mol Cell Cardiol. 2006
PubMed ID: 16466740
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
Srinivas H, Xia D, Moore NL, Uray IP, Kim H, Ma L, Weigel NL, Brown PH, Kurie JM
Biochem J. 2006
PubMed ID: 16417524
Cyclic and characteristic expression of phosphorylated Akt in human endometrium and decidual cells in vivo and in vitro.
Toyofuku A, Hara T, Taguchi T, Katsura Y, Ohama K, Kudo Y
Hum Reprod. 2006
PubMed ID: 16373405
Effects of chronic Akt activation on glucose uptake in the heart.
Matsui T, Nagoshi T, Hong EG, Luptak I, Hartil K, Li L, Gorovits N, Charron MJ, Kim JK, Tian R, Rosenzweig A
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16352665
alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.
Karkoulias G, Mastrogianni O, Lymperopoulos A, Paris H, Flordellis C
Cell Signal. 2006
PubMed ID: 16098714
The 47kDa Akt substrate associates with phosphodiesterase 3B and regulates its level in adipocytes.
Chavez JA, Gridley S, Sano H, Lane WS, Lienhard GE
Biochem Biophys Res Commun. 2006
PubMed ID: 16516160
Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation.
He L, Simmen FA, Mehendale HM, Ronis MJ, Badger TM
J Biol Chem. 2006
PubMed ID: 16452480
The phosphoinositide 3-kinase/Akt-signal pathway mediates proliferation and secretory function of hepatic sinusoidal endothelial cells in rats after partial hepatectomy.
Ping C, Lin Z, Jiming D, Jin Z, Ying L, Shigang D, Hongtao Y, Yongwei H, Jiahong D
Biochem Biophys Res Commun. 2006
PubMed ID: 16596723
Metallothionein antagonizes aging-induced cardiac contractile dysfunction: role of PTP1B, insulin receptor tyrosine phosphorylation and Akt.
Fang CX, Doser TA, Yang X, Sreejayan N, Ren J
Aging Cell. 2006
PubMed ID: 16626396
Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway.
Yu XR, Jia GR, Gao GD, Wang SH, Han Y, Cao W
Acta Biochim Biophys Sin (Shanghai). 2006
PubMed ID: 16604263
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation.
Chen YH, Wu HL, Li C, Huang YH, Chiang CW, Wu MP, Wu LW
Thromb Haemost. 2006
PubMed ID: 16601838
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta.
Nadra K, Anghel SI, Joye E, Tan NS, Basu-Modak S, Trono D, Wahli W, Desvergne B
Mol Cell Biol. 2006
PubMed ID: 16581799
Protein kinase Balpha is required for vesicle trafficking and class II presentation of IgA Fc receptor (CD89)-targeted antigen.
Lang GA, Lang ML
J Immunol. 2006
PubMed ID: 16547233
Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt.
Pengal RA, Ganesan LP, Wei G, Fang H, Ostrowski MC, Tridandapani S
Mol Immunol. 2006
PubMed ID: 16263172
Expression of caveolin-1 is correlated with Akt-1 in colorectal cancer tissues.
Kim HA, Kim KH, Lee RA
Exp Mol Pathol. 2006
PubMed ID: 16202996
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.
Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2006
PubMed ID: 16514068
Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells.
Nakai Y, Zheng Y, MacCollin M, Ratner N
J Neurosci. 2006
PubMed ID: 16571745
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.
Riobó NA, Lu K, Ai X, Haines GM, Emerson CP
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537363
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell MJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537497
Antagonistic effects of oxidized low density lipoprotein and alpha-tocopherol on CD36 scavenger receptor expression in monocytes: involvement of protein kinase B and peroxisome proliferator-activated receptor-gamma.
Munteanu A, Taddei M, Tamburini I, Bergamini E, Azzi A, Zingg JM
J Biol Chem. 2006
PubMed ID: 16407258
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways.
Um M, Lodish HF
J Biol Chem. 2006
PubMed ID: 16407271
Tryptase activates PKB in inflammatory reaction in ECV304 cells.
Ma Y, Zhang B, Qian R, Lu C, Zhao F, Yin L
Biochim Biophys Acta. 2006
PubMed ID: 16564100
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C
Genes Dev. 2006
PubMed ID: 16510873
CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.
Narayan P, Holt B, Tosti R, Kane LP
Mol Cell Biol. 2006
PubMed ID: 16508008
Functional diversity of flavonoids in the inhibition of the proinflammatory NF-kappaB, IRF, and Akt signaling pathways in murine intestinal epithelial cells.
Ruiz PA, Haller D
J Nutr. 2006
PubMed ID: 16484540
The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.
Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, Podor TJ, Gleave M, Sorensen PH
Mol Cell Biol. 2006
PubMed ID: 16478996
PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts.
Baudry A, Yang ZZ, Hemmings BA
J Cell Sci. 2006
PubMed ID: 16478789
Downregulation of protein kinase B/Akt-1 mediates INS-1 insulinoma cell apoptosis induced by dominant-negative suppression of hepatocyte nuclear factor-1alpha function.
Wobser H, Bonner C, Nolan JJ, Byrne MM, Prehn JH
Diabetologia. 2006
PubMed ID: 16440211
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth.
Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ
Blood. 2006
PubMed ID: 16282349
Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway.
McDonald CA, Millena AC, Reddy S, Finlay S, Vizcarra J, Khan SA, Davis JS
Mol Endocrinol. 2006
PubMed ID: 16269516
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation.
Ghaffari S, Kitidis C, Zhao W, Marinkovic D, Fleming MD, Luo B, Marszalek J, Lodish HF
Blood. 2006
PubMed ID: 16254141
Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice.
Ito Y, Obara K, Ikeda R, Ishii M, Tanabe Y, Ishikawa T, Nakayama K
Pflugers Arch. 2006
PubMed ID: 16244881
Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells.
Wu EH, Wong YH
Cell Signal. 2006
PubMed ID: 15979279
Casein kinase Iepsilon down-regulates phospho-Akt via PTEN, following genotoxic stress-induced apoptosis in hematopoietic cells.
Okamura A, Iwata N, Tamekane A, Yakushijin K, Nishikawa S, Hamaguchi M, Fukui C, Yamamoto K, Matsui T
Life Sci. 2006
PubMed ID: 16274701
Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for met-triggered cortical neuron migration.
Segarra J, Balenci L, Drenth T, Maina F, Lamballe F
J Biol Chem. 2006
PubMed ID: 16361255
Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
Hers I, Wherlock M, Homma Y, Yagisawa H, Tavaré JM
J Biol Chem. 2006
PubMed ID: 16338927
Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death.
Yin KJ, Hsu CY, Hu XY, Chen H, Chen SW, Xu J, Lee JM
J Neurosci. 2006
PubMed ID: 16495456
Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion.
Kovacs K, Toth A, Deres P, Kalai T, Hideg K, Gallyas F, Sumegi B
Biochem Pharmacol. 2006
PubMed ID: 16337154
Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes.
Li L, Sampat K, Hu N, Zakari J, Yuspa SH
J Biol Chem. 2006
PubMed ID: 16338928
Sustained activation of phosphatidylinositol 3-kinase/Akt/nuclear factor kappaB signaling mediates G protein-coupled delta-opioid receptor gene expression.
Chen YL, Law PY, Loh HH
J Biol Chem. 2006
PubMed ID: 16316997
PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells.
Hyoda K, Hosoi T, Horie N, Okuma Y, Ozawa K, Nomura Y
Biochem Biophys Res Commun. 2006
PubMed ID: 16375864
Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway.
Yoshimura T, Arimura N, Kawano Y, Kawabata S, Wang S, Kaibuchi K
Biochem Biophys Res Commun. 2006
PubMed ID: 16343426
GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway.
Anitha M, Gondha C, Sutliff R, Parsadanian A, Mwangi S, Sitaraman SV, Srinivasan S
J Clin Invest. 2006
PubMed ID: 16453021
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt.
Mukai Y, Rikitake Y, Shiojima I, Wolfrum S, Satoh M, Takeshita K, Hiroi Y, Salomone S, Kim HH, Benjamin LE, Walsh K, Liao JK
J Clin Invest. 2006
PubMed ID: 16453020
Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.
Yang C, Liu Y, Lemmon MA, Kazanietz MG
Mol Cell Biol. 2006
PubMed ID: 16428439
Absence of significant associations between four AKT1 SNP markers and schizophrenia in the Taiwanese population.
Liu YL, Fann CS, Liu CM, Wu JY, Hung SI, Chan HY, Chen JJ, Pan CC, Liu SK, Hsieh MH, Hwang TJ, Ouyang WC, Chen CY, Lin JJ, Chou FH, Chueh CM, Liu WM, Tsuang MM, Faraone SV, Tsuang MT, Chen WJ, Hwu HG
Psychiatr Genet. 2006
PubMed ID: 16395129
The Akt pathway in human breast cancer: a tissue-array-based analysis.
Bose S, Chandran S, Mirocha JM, Bose N
Mod Pathol. 2006
PubMed ID: 16341149
Relative contribution of G-protein-coupled pathways to protease-activated receptor-mediated Akt phosphorylation in platelets.
Kim S, Jin J, Kunapuli SP
Blood. 2006
PubMed ID: 16223779
Positive association of AKT1 haplotype to Japanese methamphetamine use disorder.
Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshiya Y, Sekine Y, Iyo M, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Inada T, Ozaki N
Int J Neuropsychopharmacol. 2006
PubMed ID: 15982448
PKB/AKT is involved in resumption of meiosis in mouse oocytes.
Kalous J, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J
Biol Cell. 2006
PubMed ID: 15842198
Protein kinase B inhibits endostatin-induced apoptosis in HUVECs.
Kang HY, Shim D, Kang SS, Chang SI, Kim HY
J Biochem Mol Biol. 2006
PubMed ID: 16466644
RNA interference targeting Akt promotes apoptosis in hypoxia-exposed human neuroblastoma cells.
Liu XH, Yu EZ, Li YY, Rollwagen FM, Kagan E
Brain Res. 2006
PubMed ID: 16405925
Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.
Biswas KK, Tancharoen S, Tancharon S, Sarker KP, Kawahara K, Hashiguchi T, Maruyama I
FEBS Lett. 2006
PubMed ID: 16412424
Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.
Evans GJ, Barclay JW, Prescott GR, Jo SR, Burgoyne RD, Birnbaum MJ, Morgan A
J Biol Chem. 2006
PubMed ID: 16243840
Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients.
Tokunaga E, Kimura Y, Oki E, Ueda N, Futatsugi M, Mashino K, Yamamoto M, Ikebe M, Kakeji Y, Baba H, Maehara Y
Int J Cancer. 2006
PubMed ID: 16049961
Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.
Qi XJ, Wildey GM, Howe PH
J Biol Chem. 2006
PubMed ID: 16282323
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation.
Song K, Wang H, Krebs TL, Danielpour D
EMBO J. 2006
PubMed ID: 16362038
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus.
Yeh PY, Kuo SH, Yeh KH, Chuang SE, Hsu CH, Chang WC, Lin HI, Gao M, Cheng AL
J Biol Chem. 2006
PubMed ID: 16280327
Role of Akt in cardiac growth and metabolism.
Muslin AJ, DeBosch B
Novartis Found Symp. 2006
PubMed ID: 17019809
Hyperoxia stimulates an Nrf2-ARE transcriptional response via ROS-EGFR-PI3K-Akt/ERK MAP kinase signaling in pulmonary epithelial cells.
Papaiahgari S, Zhang Q, Kleeberger SR, Cho HY, Reddy SP
Antioxid Redox Signal. 2006
PubMed ID: 16487036
Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species.
Evdokimova V, Ruzanov P, Anglesio MS, Sorokin AV, Ovchinnikov LP, Buckley J, Triche TJ, Sonenberg N, Sorensen PH
Mol Cell Biol. 2006
PubMed ID: 16354698
Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging.
Majumdar AP, Du J
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16123202
CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12.
Chinni SR, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD, Cher ML
Prostate. 2006
PubMed ID: 16114056
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS
J Cell Biol. 2005
PubMed ID: 16365168
Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.
Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y
Cancer Res. 2005
PubMed ID: 16357133
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo.
Ha T, Li Y, Gao X, McMullen JR, Shioi T, Izumo S, Kelley JL, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C
Free Radic Biol Med. 2005
PubMed ID: 16298682
Specific role for p85/p110beta in GTP-binding-protein-mediated activation of Akt.
Kubo H, Hazeki K, Takasuga S, Hazeki O
Biochem J. 2005
PubMed ID: 16091017
Nuclear targeting of Akt enhances ventricular function and myocyte contractility.
Rota M, Boni A, Urbanek K, Padin-Iruegas ME, Kajstura TJ, Fiore G, Kubo H, Sonnenblick EH, Musso E, Houser SR, Leri A, Sussman MA, Anversa P
Circ Res. 2005
PubMed ID: 16293788
Cell-specific regulation of androgen receptor phosphorylation in vivo.
Taneja SS, Ha S, Swenson NK, Huang HY, Lee P, Melamed J, Shapiro E, Garabedian MJ, Logan SK
J Biol Chem. 2005
PubMed ID: 16210317
Physiological and pathological changes in glucose regulate brain Akt and glycogen synthase kinase-3.
Clodfelder-Miller B, De Sarno P, Zmijewska AA, Song L, Jope RS
J Biol Chem. 2005
PubMed ID: 16179343
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice.
Yang ZZ, Tschopp O, Di-Poï N, Bruder E, Baudry A, Dümmler B, Wahli W, Hemmings BA
Mol Cell Biol. 2005
PubMed ID: 16287854
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2.
Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL
Nat Neurosci. 2005
PubMed ID: 16286931
Expression of Akt (protein kinase B) and its isoforms in malignant lymphomas.
Fillmore GC, Wang Q, Carey MJ, Kim CH, Elenitoba-Johnson KS, Lim MS
Leuk Lymphoma. 2005
PubMed ID: 16263580
Brain-derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt pathways.
Kilic E, Kilic U, Soliz J, Bassetti CL, Gassmann M, Hermann DM
FASEB J. 2005
PubMed ID: 16207820
Albumin endocytosis in proximal tubule cells is modulated by angiotensin II through an AT2 receptor-mediated protein kinase B activation.
Caruso-Neves C, Kwon SH, Guggino WB
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16293694
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
Park S, Kim D, Kaneko S, Szewczyk KM, Nicosia SV, Yu H, Jove R, Cheng JQ
J Biol Chem. 2005
PubMed ID: 16174774
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.
Chen CS, Weng SC, Tseng PH, Lin HP, Chen CS
J Biol Chem. 2005
PubMed ID: 16186112
Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.
Miyamoto S, Howes AL, Adams JW, Dorn GW, Brown JH
J Biol Chem. 2005
PubMed ID: 16061478
Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.
Katsanakis KD, Pillay TS
J Biol Chem. 2005
PubMed ID: 16141217
X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling.
Takeuchi H, Kim J, Fujimoto A, Umetani N, Mori T, Bilchik A, Turner R, Tran A, Kuo C, Hoon DS
Clin Cancer Res. 2005
PubMed ID: 16278380
Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.
Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwäble J, Buerger H, Müller-Tidow C, Choudhary C, McMahon M, Berdel WE, Serve H
Cancer Res. 2005
PubMed ID: 16266983
Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells.
Yamamoto S, Yoshino I, Shimazaki T, Murohashi M, Hevner RF, Lax I, Okano H, Shibuya M, Schlessinger J, Gotoh N
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16239343
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Chen J, Somanath PR, Razorenova O, Chen WS, Hay N, Bornstein P, Byzova TV
Nat Med. 2005
PubMed ID: 16227992
Glimepiride induces nitric oxide production in human coronary artery endothelial cells via a PI3-kinase-Akt dependent pathway.
Ueba H, Kuroki M, Hashimoto S, Umemoto T, Yasu T, Ishikawa SE, Saito M, Kawakami M
Atherosclerosis. 2005
PubMed ID: 16216590
Thyroid hormone activates Akt and prevents serum starvation-induced cell death in neonatal rat cardiomyocytes.
Kuzman JA, Gerdes AM, Kobayashi S, Liang Q
J Mol Cell Cardiol. 2005
PubMed ID: 16171808
Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice.
Haga S, Ogawa W, Inoue H, Terui K, Ogino T, Igarashi R, Takeda K, Akira S, Enosawa S, Furukawa H, Todo S, Ozaki M
J Hepatol. 2005
PubMed ID: 16083985
Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases.
Jung HS, Kim DW, Jo YS, Chung HK, Song JH, Park JS, Park KC, Park SH, Hwang JH, Jo KW, Shong M
Mol Endocrinol. 2005
PubMed ID: 15994200
Akt/Bad signaling and motor neuron survival after spinal cord injury.
Yu F, Sugawara T, Maier CM, Hsieh LB, Chan PH
Neurobiol Dis. 2005
PubMed ID: 15896972
Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.
Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F, Varbiro G, Sumegi B
J Biol Chem. 2005
PubMed ID: 16115861
Estradiol prevents the injury-induced decrease of Akt activation and Bad phosphorylation.
Won CK, Ha SJ, Noh HS, Kang SS, Cho GJ, Choi WS, Koh PO
Neurosci Lett. 2005
PubMed ID: 16087293
Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats.
Zhao H, Shimohata T, Wang JQ, Sun G, Schaal DW, Sapolsky RM, Steinberg GK
J Neurosci. 2005
PubMed ID: 16237183
Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.
Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K
EMBO J. 2005
PubMed ID: 16177823
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC
Science. 2005
PubMed ID: 16224021
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
Tudor EL, Perkinton MS, Schmidt A, Ackerley S, Brownlees J, Jacobsen NJ, Byers HL, Ward M, Hall A, Leigh PN, Shaw CE, McLoughlin DM, Miller CC
J Biol Chem. 2005
PubMed ID: 16049005
Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by alpha platelet-derived growth factor receptor.
Dolloff NG, Shulby SS, Nelson AV, Stearns ME, Johannes GJ, Thomas JD, Meucci O, Fatatis A
Oncogene. 2005
PubMed ID: 16007172
Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells.
Jeong SJ, Pise-Masison CA, Radonovich MF, Park HU, Brady JN
Oncogene. 2005
PubMed ID: 16007163
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
Chen L, Gilkes DM, Pan Y, Lane WS, Chen J
EMBO J. 2005
PubMed ID: 16163388
Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family.
Matsuzaki H, Ichino A, Hayashi T, Yamamoto T, Kikkawa U
J Biochem. 2005
PubMed ID: 16272144
The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis.
Li Q, Ishikawa TO, Oshima M, Taketo MM
Cancer Res. 2005
PubMed ID: 16204028
Neuroprotection by stem cell factor in rat cortical neurons involves AKT and NFkappaB.
Dhandapani KM, Wade FM, Wakade C, Mahesh VB, Brann DW
J Neurochem. 2005
PubMed ID: 16181409
Corneal cell survival in adenovirus type 19 infection requires phosphoinositide 3-kinase/Akt activation.
Rajala MS, Rajala RV, Astley RA, Butt AL, Chodosh J
J Virol. 2005
PubMed ID: 16160160
Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root ganglia.
Knabe W, Sirén AL, Ehrenreich H, Kuhn HJ
Anat Embryol (Berl). 2005
PubMed ID: 16151855
A role for PI3K-Akt signaling in pulmonary metastatic nodule formation of the osteosarcoma cell line, LM8.
Fukaya Y, Ishiguro N, Senga T, Ichigotani Y, Sohara Y, Tsutsui M, Shioura T, Iwamoto T, Hamaguchi M
Oncol Rep. 2005
PubMed ID: 16142341
T-cadherin protects endothelial cells from oxidative stress-induced apoptosis.
Joshi MB, Philippova M, Ivanov D, Allenspach R, Erne P, Resink TJ
FASEB J. 2005
PubMed ID: 16099944
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.
Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A
Oncogene. 2005
PubMed ID: 16007182
Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B.
Ferreira IA, Mocking AI, Urbanus RT, Varlack S, Wnuk M, Akkerman JW
J Biol Chem. 2005
PubMed ID: 16049004
Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.
Calautti E, Li J, Saoncella S, Brissette JL, Goetinck PF
J Biol Chem. 2005
PubMed ID: 16036919
Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt.
Chen YC, Su YN, Chou PC, Chiang WC, Chang MC, Wang LS, Teng SC, Wu KJ
J Biol Chem. 2005
PubMed ID: 16036916
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.
Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N
J Biol Chem. 2005
PubMed ID: 16027121
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.
Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons ME, Krawczyk CM, Gerondakis S, Yeh WC, Woodgett JR, Boothby MR, Ohashi PS
J Immunol. 2005
PubMed ID: 16148125
Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families.
Schwab SG, Hoefgen B, Hanses C, Hassenbach MB, Albus M, Lerer B, Trixler M, Maier W, Wildenauer DB
Biol Psychiatry. 2005
PubMed ID: 16026766
Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins.
Klein JB, Barati MT, Wu R, Gozal D, Sachleben LR, Kausar H, Trent JO, Gozal E, Rane MJ
J Biol Chem. 2005
PubMed ID: 16027165
Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.
Thimmaiah KN, Easton JB, Germain GS, Morton CL, Kamath S, Buolamwini JK, Houghton PJ
J Biol Chem. 2005
PubMed ID: 16009706
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
A new mouse model of pancreatic cancer: PTEN gets its Akt together.
Maitra A, Hruban RH
Cancer Cell. 2005
PubMed ID: 16169459
Akt/PKB regulates actin organization and cell motility via Girdin/APE.
Enomoto A, Murakami H, Asai N, Morone N, Watanabe T, Kawai K, Murakumo Y, Usukura J, Kaibuchi K, Takahashi M
Dev Cell. 2005
PubMed ID: 16139227
The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.
Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM
Mol Cell Biol. 2005
PubMed ID: 16135819
Ribozymes targeting serine/threonine kinase Akt1 sensitize cells to anticancer drugs.
Yanagihara M, Katano M, Takahashi-Sasaki N, Kimata K, Taira K, Andoh T
Cancer Sci. 2005
PubMed ID: 16128748
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells.
Götz R, Wiese S, Takayama S, Camarero GC, Rossoll W, Schweizer U, Troppmair J, Jablonka S, Holtmann B, Reed JC, Rapp UR, Sendtner M
Nat Neurosci. 2005
PubMed ID: 16116448
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.
Kadri Z, Maouche-Chretien L, Rooke HM, Orkin SH, Romeo PH, Mayeux P, Leboulch P, Chretien S
Mol Cell Biol. 2005
PubMed ID: 16107690
Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells.
Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AM
Am J Respir Cell Mol Biol. 2005
PubMed ID: 15961723
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells.
Dihlmann S, Kloor M, Fallsehr C, von Knebel Doeberitz M
Carcinogenesis. 2005
PubMed ID: 15888491
Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal muscle.
Creer A, Gallagher P, Slivka D, Jemiolo B, Fink W, Trappe S
J Appl Physiol. 2005
PubMed ID: 15879168
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.
Tee AR, Blenis J, Proud CG
FEBS Lett. 2005
PubMed ID: 16098514
Erythropoietin attenuated high glucose-induced apoptosis in cultured human aortic endothelial cells.
Sekiguchi N, Inoguchi T, Kobayashi K, Sonoda N, Nawata H
Biochem Biophys Res Commun. 2005
PubMed ID: 15993382
The antiapoptotic effect of fibroblast growth factor-2 is mediated through nuclear factor-kappaB activation induced via interaction between Akt and IkappaB kinase-beta in breast cancer cells.
Vandermoere F, El Yazidi-Belkoura I, Adriaenssens E, Lemoine J, Hondermarck H
Oncogene. 2005
PubMed ID: 15856005
The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo.
Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Ratajczak CK, Moley KH
Dev Biol. 2005
PubMed ID: 16005454
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation.
Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16076959
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.
Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC
J Clin Invest. 2005
PubMed ID: 16075056
Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.
Basile JR, Afkhami T, Gutkind JS
Mol Cell Biol. 2005
PubMed ID: 16055703
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2.
Manning BD, Logsdon MN, Lipovsky AI, Abbott D, Kwiatkowski DJ, Cantley LC
Genes Dev. 2005
PubMed ID: 16027169
PTEN-positive and phosphorylated-Akt-negative expression is a predictor of survival for patients with advanced endometrial carcinoma.
Uegaki K, Kanamori Y, Kigawa J, Kawaguchi W, Kaneko R, Naniwa J, Takahashi M, Shimada M, Oishi T, Itamochi H, Terakawa N
Oncol Rep. 2005
PubMed ID: 16012720
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury.
Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, del Monte F, Gwathmey JK, Grazette L, Hemmings BA, Hemmings B, Kass DA, Champion HC, Rosenzweig A
J Clin Invest. 2005
PubMed ID: 16007268
Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
Auld GC, Campbell DG, Morrice N, Cohen P
Biochem J. 2005
PubMed ID: 15910284
L-Thyroxine activates Akt signaling in the heart.
Kuzman JA, Vogelsang KA, Thomas TA, Gerdes AM
J Mol Cell Cardiol. 2005
PubMed ID: 15890358
PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells.
Hu H, Jiang C, Li G, Lü J
Carcinogenesis. 2005
PubMed ID: 15845651
Cyclic AMP induces morphological changes of vascular smooth muscle cells by inhibiting a Rac-dependent signaling pathway.
Pelletier S, Julien C, Popoff MR, Lamarche-Vane N, Meloche S
J Cell Physiol. 2005
PubMed ID: 15706595
An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG
Cell. 2005
PubMed ID: 16051150
A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death.
Auger R, Motta I, Benihoud K, Ojcius DM, Kanellopoulos JM
J Biol Chem. 2005
PubMed ID: 15937334
Integrin-linked kinase deletion from mouse cortex results in cortical lamination defects resembling cobblestone lissencephaly.
Niewmierzycka A, Mills J, St-Arnaud R, Dedhar S, Reichardt LF
J Neurosci. 2005
PubMed ID: 16049178
Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling.
Naito AT, Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I
Circ Res. 2005
PubMed ID: 15994435
Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators.
Song JJ, Lee YJ
J Biol Chem. 2005
PubMed ID: 15911620
NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells.
Mendoza-Milla C, Machuca Rodríguez C, Córdova Alarcón E, Estrada Bernal A, Toledo-Cuevas EM, Martínez Martínez E, Zentella Dehesa A
FEBS Lett. 2005
PubMed ID: 16000198
Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway.
Nho RS, Xia H, Kahm J, Kleidon J, Diebold D, Henke CA
J Biol Chem. 2005
PubMed ID: 15905178
The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J
Chandrasekar B, Mummidi S, Valente AJ, Patel DN, Bailey SR, Freeman GL, Hatano M, Tokuhisa T, Jensen LE
J Biol Chem. 2005
PubMed ID: 15890643
Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1-MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop.
Song JJ, Lee YJ
J Cell Biol. 2005
PubMed ID: 15998799
Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages.
Kao SJ, Lei HC, Kuo CT, Chang MS, Chen BC, Chang YC, Chiu WT, Lin CH
Immunology. 2005
PubMed ID: 15946254
PKB mediates c-erbB2-induced epithelial beta1 integrin conformational inactivation through Rho-independent F-actin rearrangements.
Hedjazifar S, Jenndahl LE, Shimokawa H, Baeckström D
Exp Cell Res. 2005
PubMed ID: 15922745
Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway.
Lu Y, Wahl LM
J Leukoc Biol. 2005
PubMed ID: 15800029
Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
Lesné S, Gabriel C, Nelson DA, White E, Mackenzie ET, Vivien D, Buisson A
J Biol Chem. 2005
PubMed ID: 15797869
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes.
Murillo MM, del Castillo G, Sánchez A, Fernández M, Fabregat I
Oncogene. 2005
PubMed ID: 15856020
Akt1 contains a functional leucine-rich nuclear export sequence.
Saji M, Vasko V, Kada F, Allbritton EH, Burman KD, Ringel MD
Biochem Biophys Res Commun. 2005
PubMed ID: 15896313
Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation.
Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J
J Biol Chem. 2005
PubMed ID: 15840586
Akt phosphorylates the Y-box binding protein 1 at Ser102 located in the cold shock domain and affects the anchorage-independent growth of breast cancer cells.
Sutherland BW, Kucab J, Wu J, Lee C, Cheang MC, Yorida E, Turbin D, Dedhar S, Nelson C, Pollak M, Leighton Grimes H, Miller K, Badve S, Huntsman D, Blake-Gilks C, Chen M, Pallen CJ, Dunn SE
Oncogene. 2005
PubMed ID: 15806160
Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.
Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K, Takai S, Akamatsu S, Kato K, Oiso Y, Kozawa O
Arch Biochem Biophys. 2005
PubMed ID: 15896702
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes.
Wijayanti N, Kietzmann T, Immenschuh S
J Biol Chem. 2005
PubMed ID: 15833736
Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.
Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S
J Biol Chem. 2005
PubMed ID: 15809304
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia ind
Phillips RJ, Mestas J, Gharaee-Kermani M, Burdick MD, Sica A, Belperio JA, Keane MP, Strieter RM
J Biol Chem. 2005
PubMed ID: 15802268
Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation.
Miao B, Yin XH, Pei DS, Zhang QG, Zhang GY
J Biol Chem. 2005
PubMed ID: 15797868
Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP
J Biol Chem. 2005
PubMed ID: 15799971
ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival.
Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ
J Biol Chem. 2005
PubMed ID: 15784622
Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis.
Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa WC, Min W
Oncogene. 2005
PubMed ID: 15782121
N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.
Bahlis NJ, Miao Y, Koc ON, Lee K, Boise LH, Gerson SL
Leuk Lymphoma. 2005
PubMed ID: 16019536
Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, Pinna LA, Ruzzene M
Cell Death Differ. 2005
PubMed ID: 15818404
C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration.
Hafizi S, Ibraimi F, Dahlbäck B
FASEB J. 2005
PubMed ID: 15817639
Akt mediates mechanical strain-induced collagen production by mesangial cells.
Krepinsky JC, Li Y, Chang Y, Liu L, Peng F, Wu D, Tang D, Scholey J, Ingram AJ
J Am Soc Nephrol. 2005
PubMed ID: 15814837
Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia.
Cascallana JL, Bravo A, Donet E, Leis H, Lara MF, Paramio JM, Jorcano JL, Pérez P
Endocrinology. 2005
PubMed ID: 15746257
Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival.
Hammerman PS, Fox CJ, Birnbaum MJ, Thompson CB
Blood. 2005
PubMed ID: 15705789
Akt regulates thrombin-induced HSP27 phosphorylation in aortic smooth muscle cells: function at a point downstream from p38 MAP kinase.
Nakajima K, Hirade K, Ishisaki A, Matsuno H, Suga H, Kanno Y, Shu E, Kitajima Y, Katagiri Y, Kozawa O
Life Sci. 2005
PubMed ID: 15848222
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.
Huang C, Thirone AC, Huang X, Klip A
J Biol Chem. 2005
PubMed ID: 15764603
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
Anai M, Shojima N, Katagiri H, Ogihara T, Sakoda H, Onishi Y, Ono H, Fujishiro M, Fukushima Y, Horike N, Viana A, Kikuchi M, Noguchi N, Takahashi S, Takata K, Oka Y, Uchijima Y, Kurihara H, Asano T
J Biol Chem. 2005
PubMed ID: 15753085
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
Cartlidge RA, Knebel A, Peggie M, Alexandrov A, Phizicky EM, Cohen P
EMBO J. 2005
PubMed ID: 15861136
The role of Akt on arsenic trioxide suppression of 3T3-L1 preadipocyte differentiation.
Wang ZX, Jiang CS, Liu L, Wang XH, Jin HJ, Wu Q, Chen Q
Cell Res. 2005
PubMed ID: 15916724
Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.
Watanabe H, Saito H, Rychahou PG, Uchida T, Evers BM
Gastroenterology. 2005
PubMed ID: 15887120
IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells.
Kawauchi K, Ihjima K, Yamada O
J Immunol. 2005
PubMed ID: 15843522
A developmental switch in the response of DRG neurons to ETS transcription factor signaling.
Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S
PLoS Biol. 2005
PubMed ID: 15836427
Angiotensin II-induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated Ca2(+)-dependent phospholipase A2.
Li F, Malik KU
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15637121
Phosphorylation of grb10 regulates its interaction with 14-3-3.
Urschel S, Bassermann F, Bai RY, Münch S, Peschel C, Duyster J
J Biol Chem. 2005
PubMed ID: 15722337
Scanning the human proteome for calmodulin-binding proteins.
Shen X, Valencia CA, Szostak JW, Szostak J, Dong B, Liu R
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15840729
GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells.
Grzesiak JJ, Smith KC, Burton DW, Deftos LJ, Bouvet M
Int J Cancer. 2005
PubMed ID: 15609321
Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis.
Menghini R, Marchetti V, Cardellini M, Hribal ML, Mauriello A, Lauro D, Sbraccia P, Lauro R, Federici M
Circulation. 2005
PubMed ID: 15837948
A cell-based screen for modulators of ataxin-1 phosphorylation.
Kaytor MD, Byam CE, Tousey SK, Stevens SD, Zoghbi HY, Orr HT
Hum Mol Genet. 2005
PubMed ID: 15757972
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC
Neoplasia. 2005
PubMed ID: 15967113
Traumatic injury activates protein kinase B/Akt in cultured astrocytes: role of extracellular ATP and P2 purinergic receptors.
Neary JT, Kang Y, Tran M, Feld J
J Neurotrauma. 2005
PubMed ID: 15853465
Akt activation, but not extracellular signal-regulated kinase activation, is required for SDF-1alpha/CXCR4-mediated migration of epitheloid carcinoma cells.
Peng SB, Peek V, Zhai Y, Paul DC, Lou Q, Xia X, Eessalu T, Kohn W, Tang S
Mol Cancer Res. 2005
PubMed ID: 15831676
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC
Mol Cell. 2005
PubMed ID: 15808505
Recent advances in the protein kinase B signaling pathway.
Woodgett JR
Curr Opin Cell Biol. 2005
PubMed ID: 15780591
Stable activation of phosphatidylinositol 3-kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control.
Fabre S, Lang V, Harriague J, Jobart A, Unterman TG, Trautmann A, Bismuth G
J Immunol. 2005
PubMed ID: 15778376
A novel Sry-downstream cellular event which preserves the readily available energy source of glycogen in mouse sex differentiation.
Matoba S, Kanai Y, Kidokoro T, Kanai-Azuma M, Kawakami H, Hayashi Y, Kurohmaru M
J Cell Sci. 2005
PubMed ID: 15769848
Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation.
Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T
J Clin Invest. 2005
PubMed ID: 15761494
Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells.
Jin ZG, Wong C, Wu J, Berk BC
J Biol Chem. 2005
PubMed ID: 15665327
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.
Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM
EMBO J. 2005
PubMed ID: 15775979
Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway.
Chanalaris A, Lawrence KM, Townsend PA, Davidson S, Jamshidi Y, Jashmidi Y, Stephanou A, Knight RD, Hsu SY, Hsueh AJ, Latchman DS
Biochem Biophys Res Commun. 2005
PubMed ID: 15694367
Inhibition of Src-like kinases reveals Akt-dependent and -independent pathways in insulin-like growth factor I-mediated oligodendrocyte progenitor survival.
Cui QL, Zheng WH, Quirion R, Almazan G
J Biol Chem. 2005
PubMed ID: 15632127
Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury.
Zhang X, Shan P, Alam J, Fu XY, Lee PJ
J Biol Chem. 2005
PubMed ID: 15590660
Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity.
Yang H, Zhao R, Yang HY, Lee MH
Oncogene. 2005
PubMed ID: 15688030
Akt is altered in an animal model of Huntington's disease and in patients.
Colin E, Régulier E, Perrin V, Dürr A, Brice A, Aebischer P, Déglon N, Humbert S, Saudou F
Eur J Neurosci. 2005
PubMed ID: 15845076
Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors.
Suomalainen L, Pentikäinen V, Dunkel L
Am J Pathol. 2005
PubMed ID: 15743789
Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.
Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, Petroulakis E, Sonenberg N, Kelly PA, Sotiropoulos A, Pende M
Nat Cell Biol. 2005
PubMed ID: 15723049
Role for Akt3/protein kinase Bgamma in attainment of normal brain size.
Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ
Mol Cell Biol. 2005
PubMed ID: 15713641
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.
Di-Poï N, Ng CY, Tan NS, Yang Z, Hemmings BA, Desvergne B, Michalik L, Wahli W
Mol Cell Biol. 2005
PubMed ID: 15713628
Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes.
Uriarte SM, Joshi-Barve S, Song Z, Sahoo R, Gobejishvili L, Jala VR, Haribabu B, McClain C, Barve S
Cell Death Differ. 2005
PubMed ID: 15665818
PI-3K/Akt and NF-kappaB/IkappaBalpha pathways are activated in Jurkat T cells in response to TRAIL treatment.
Zauli G, Sancilio S, Cataldi A, Sabatini N, Bosco D, Di Pietro R
J Cell Physiol. 2005
PubMed ID: 15389633
DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.
Dragoi AM, Fu X, Ivanov S, Zhang P, Sheng L, Wu D, Li GC, Chu WM
EMBO J. 2005
PubMed ID: 15678105
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM
Science. 2005
PubMed ID: 15718470
Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter.
Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC
J Biol Chem. 2005
PubMed ID: 15583002
Proteomic analysis of in vivo phosphorylated synaptic proteins.
Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG
J Biol Chem. 2005
PubMed ID: 15572359
A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.
Kanekura K, Hashimoto Y, Kita Y, Sasabe J, Aiso S, Nishimoto I, Matsuoka M
J Biol Chem. 2005
PubMed ID: 15579468
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.
Viniegra JG, Martínez N, Modirassari P, Losa JH, Parada Cobo C, Lobo VJ, Luquero CI, Alvarez-Vallina L, Ramón y Cajal S, Rojas JM, Sánchez-Prieto R
J Biol Chem. 2005
PubMed ID: 15546863
Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.
Sugatani T, Hruska KA
J Biol Chem. 2005
PubMed ID: 15545269
AKT plays a role in the survival of the tumor cells of extranodal NK/T-cell lymphoma, nasal type.
Chow C, Liu AY, Chan WS, Lei KI, Chan WY, Lo AW
Haematologica. 2005
PubMed ID: 15710591
PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung.
Wang J, Ito T, Udaka N, Okudela K, Yazawa T, Kitamura H
Tissue Cell. 2005
PubMed ID: 15695173
Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress.
Saito A, Hayashi T, Okuno S, Nishi T, Chan PH
J Cereb Blood Flow Metab. 2005
PubMed ID: 15678128
A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells.
Huang FC, Li Q, Cherayil BJ
FEMS Microbiol Lett. 2005
PubMed ID: 15668028
Functional proteomic analysis of a three-tier PKCepsilon-Akt-eNOS signaling module in cardiac protection.
Zhang J, Baines CP, Zong C, Cardwell EM, Wang G, Vondriska TM, Ping P
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15528226
Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.
Cho YL, Lee KS, Lee SJ, Namkoong S, Kim YM, Lee H, Ha KS, Han JA, Kwon YG, Kim YM
Biochem Biophys Res Commun. 2005
PubMed ID: 15607733
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
Kippenberger S, Loitsch S, Guschel M, Müller J, Knies Y, Kaufmann R, Bernd A
J Biol Chem. 2005
PubMed ID: 15545271
Regulated association of protein kinase B/Akt with breast tumor kinase.
Zhang P, Ostrander JH, Faivre EJ, Olsen A, Fitzsimmons D, Lange CA
J Biol Chem. 2005
PubMed ID: 15539407
The loss of glypican-3 induces alterations in Wnt signaling.
Song HH, Shi W, Xiang YY, Filmus J
J Biol Chem. 2005
PubMed ID: 15537637
Microvascular patterning is controlled by fine-tuning the Akt signal.
Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15611473
Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2.
Cicenas J, Urban P, Vuaroqueaux V, Labuhn M, Küng W, Wight E, Mayhew M, Eppenberger U, Eppenberger-Castori S
Breast Cancer Res. 2005
PubMed ID: 15987444
Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120.
Langford D, Hurford R, Hashimoto M, Digicaylioglu M, Masliah E
BMC Neurosci. 2005
PubMed ID: 15689238
Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death.
Taylor JM, Ali U, Iannello RC, Hertzog P, Crack PJ
J Neurochem. 2005
PubMed ID: 15663476
Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity.
Bruss MD, Arias EB, Lienhard GE, Cartee GD
Diabetes. 2005
PubMed ID: 15616009
HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
Kino T, De Martino MU, Charmandari E, Ichijo T, Outas T, Chrousos GP
Diabetes. 2005
PubMed ID: 15616007
Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development.
Kang JO, Sucov HM
Mech Dev. 2005
PubMed ID: 15582777
Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage.
Wanzel M, Kleine-Kohlbrecher D, Herold S, Hock A, Berns K, Park J, Hemmings B, Eilers M
Nat Cell Biol. 2005
PubMed ID: 15580267
R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho.
Wozniak MA, Kwong L, Chodniewicz D, Klemke RL, Keely PJ
Mol Biol Cell. 2005
PubMed ID: 15525681
Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects.
Stirone C, Boroujerdi A, Duckles SP, Krause DN
Mol Pharmacol. 2005
PubMed ID: 15496504
Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein.
Ellert-Miklaszewska A, Kaminska B, Konarska L
Cell Signal. 2005
PubMed ID: 15451022
Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts.
Cao X, Kambe F, Moeller LC, Refetoff S, Seo H
Mol Endocrinol. 2005
PubMed ID: 15388791
The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.
Smith PG, Wang F, Wilkinson KN, Savage KJ, Klein U, Neuberg DS, Bollag G, Shipp MA, Aguiar RC
Blood. 2005
PubMed ID: 15331441
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
J Biol Chem. 2004
PubMed ID: 15485887
Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.
Hiromura M, Okada F, Obata T, Auguin D, Shibata T, Roumestand C, Noguchi M
J Biol Chem. 2004
PubMed ID: 15459205
The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt.
Rose A, Froment P, Perrot V, Quon MJ, LeRoith D, Dupont J
J Biol Chem. 2004
PubMed ID: 15448167
Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.
Salinas M, Wang J, Rosa de Sagarra M, Martín D, Rojo AI, Martin-Perez J, Ortiz de Montellano PR, Cuadrado A
FEBS Lett. 2004
PubMed ID: 15581622
Transcriptional regulation of AKT activation by E2F.
Chaussepied M, Ginsberg D
Mol Cell. 2004
PubMed ID: 15574337
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak.
Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N
Mol Cell. 2004
PubMed ID: 15574336
Antiapoptotic activity of Akt is down-regulated by Ca2+ in myocardiac H9c2 cells. Evidence of Ca(2+)-dependent regulation of protein phosphatase 2Ac.
Yasuoka C, Ihara Y, Ikeda S, Miyahara Y, Kondo T, Kohno S
J Biol Chem. 2004
PubMed ID: 15375154
PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.
Aeder SE, Martin PM, Soh JW, Hussaini IM
Oncogene. 2004
PubMed ID: 15489897
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation.
Tessner TG, Muhale F, Riehl TE, Anant S, Stenson WF
J Clin Invest. 2004
PubMed ID: 15578100
Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT.
Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M
Mol Cell Biol. 2004
PubMed ID: 15572689
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.
Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavaré JM
J Cell Sci. 2004
PubMed ID: 15546921
The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis.
Cabane C, Coldefy AS, Yeow K, Dérijard B
Cell Signal. 2004
PubMed ID: 15381256
EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes.
Andl CD, Mizushima T, Oyama K, Bowser M, Nakagawa H, Rustgi AK
Am J Physiol Gastrointest Liver Physiol. 2004
PubMed ID: 15284024
Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways.
Calabro P, Samudio I, Willerson JT, Yeh ET
Circulation. 2004
PubMed ID: 15545519
Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
Misra UK, Pizzo SV
J Cell Biochem. 2004
PubMed ID: 15389876
Integrin signaling links protein kinase Cepsilon to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells.
Wu D, Thakore CU, Wescott GG, McCubrey JA, Terrian DM
Oncogene. 2004
PubMed ID: 15467757
Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway.
Portis T, Longnecker R
Oncogene. 2004
PubMed ID: 15361852
Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.
Manning BD
J Cell Biol. 2004
PubMed ID: 15533996
A novel site of AKT-mediated phosphorylation in the human MDM2 onco-protein.
Milne D, Kampanis P, Nicol S, Dias S, Campbell DG, Fuller-Pace F, Meek D
FEBS Lett. 2004
PubMed ID: 15527798
Effects of chronic renal failure on caveolin-1, guanylate cyclase and AKT protein expression.
Sindhu RK, Ehdaie A, Vaziri ND, Roberts CK
Biochim Biophys Acta. 2004
PubMed ID: 15511630
Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells.
Koga M, Hirano K, Hirano M, Nishimura J, Nakano H, Kanaide H
Biochem Biophys Res Commun. 2004
PubMed ID: 15465021
Association of AKT1 with schizophrenia confirmed in a Japanese population.
Ikeda M, Iwata N, Suzuki T, Kitajima T, Yamanouchi Y, Kinoshita Y, Inada T, Ozaki N
Biol Psychiatry. 2004
PubMed ID: 15522255
Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.
Liu J, Puscheck EE, Wang F, Trostinskaia A, Barisic D, Maniere G, Wygle D, Zhong W, Rings EH, Rappolee DA
Reproduction. 2004
PubMed ID: 15509711
Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation.
Tiffin N, Adi S, Stokoe D, Wu NY, Rosenthal SM
Endocrinology. 2004
PubMed ID: 15489316
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.
Pore N, Liu S, Shu HK, Li B, Haas-Kogan D, Stokoe D, Milanini-Mongiat J, Pages G, O'Rourke DM, Bernhard E, Maity A
Mol Biol Cell. 2004
PubMed ID: 15342781
Failure to confirm association between AKT1 haplotype and schizophrenia in a Japanese case-control population.
Ohtsuki T, Inada T, Arinami T
Mol Psychiatry. 2004
PubMed ID: 15263908
In situ Akt phosphorylation in the nucleus tractus solitarii is involved in central control of blood pressure and heart rate.
Huang HN, Lu PJ, Lo WC, Lin CH, Hsiao M, Tseng CJ
Circulation. 2004
PubMed ID: 15466647
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Kamon J, Yamauchi T, Muto S, Takekawa S, Ito Y, Hada Y, Ogawa W, Itai A, Kasuga M, Tobe K, Kadowaki T
Biochem Biophys Res Commun. 2004
PubMed ID: 15351728
Signal transduction via the stem cell factor receptor/c-Kit.
Rönnstrand L
Cell Mol Life Sci. 2004
PubMed ID: 15526160
Akt activation protects rat liver from ischemia/reperfusion injury.
Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N, Brenner DA, Yamaoka Y
J Surg Res. 2004
PubMed ID: 15501455
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence.
Ayala G, Thompson T, Yang G, Frolov A, Li R, Scardino P, Ohori M, Wheeler T, Harper W
Clin Cancer Res. 2004
PubMed ID: 15475446
The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10.
Dahle MK, Øverland G, Myhre AE, Stuestøl JF, Hartung T, Krohn CD, Mathiesen Ø, Wang JE, Aasen AO
Infect Immun. 2004
PubMed ID: 15385469
17beta-estradiol reduces cardiomyocyte apoptosis in vivo and in vitro via activation of phospho-inositide-3 kinase/Akt signaling.
Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, Michael A, Haq S, Nuedling S, Grohe C, Force T, Mendelsohn ME, Karas RH
Circ Res. 2004
PubMed ID: 15345655
Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons.
Leinninger GM, Backus C, Uhler MD, Lentz SI, Feldman EL
FASEB J. 2004
PubMed ID: 15319368
Estrogen exerts neuroprotective effects via membrane estrogen receptors and rapid Akt/NOS activation.
Alexaki VI, Charalampopoulos I, Kampa M, Vassalou H, Theodoropoulos P, Stathopoulos EN, Hatzoglou A, Gravanis A, Castanas E
FASEB J. 2004
PubMed ID: 15289442
BAD is a pro-survival factor prior to activation of its pro-apoptotic function.
Seo SY, Chen YB, Ivanovska I, Ranger AM, Hong SJ, Dawson VL, Korsmeyer SJ, Bellows DS, Fannjiang Y, Hardwick JM
J Biol Chem. 2004
PubMed ID: 15231831
Akt-1 expression level regulates CNS precursors.
Sinor AD, Lillien L
J Neurosci. 2004
PubMed ID: 15456827
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
Feng J, Park J, Cron P, Hess D, Hemmings BA
J Biol Chem. 2004
PubMed ID: 15262962
Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer.
Emanueli C, Salis MB, Van Linthout S, Meloni M, Desortes E, Silvestre JS, Clergue M, Figueroa CD, Gadau S, Condorelli G, Madeddu P
Circulation. 2004
PubMed ID: 15364809
The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
Wong CK, Luo W, Deng Y, Zou H, Ye Z, Lin SC
J Biol Chem. 2004
PubMed ID: 15262978
Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors.
Zhang J, Lodish HF
Blood. 2004
PubMed ID: 15166036
Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice.
Chen J, De S, Damron DS, Chen WS, Hay N, Byzova TV
Blood. 2004
PubMed ID: 15105289
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15342917
Calmodulin-mediated activation of Akt regulates survival of c-Myc-overexpressing mouse mammary carcinoma cells.
Deb TB, Coticchia CM, Dickson RB
J Biol Chem. 2004
PubMed ID: 15247222
Protein kinase B, P34cdc2 kinase, and p21 ras GTP-binding in kidneys of aging rats.
Parekh VV, Falcone JC, Wills-Frank LA, Joshua IG, Dholakia JN, Passmore JC
Exp Biol Med (Maywood). 2004
PubMed ID: 15337841
Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus.
Vigorito E, Bardi G, Glassford J, Lam EW, Clayton E, Turner M
J Immunol. 2004
PubMed ID: 15322182
beta1-Integrins induce phosphorylation of Akt on serine 473 independently of focal adhesion kinase and Src family kinases.
Velling T, Nilsson S, Stefansson A, Johansson S
EMBO Rep. 2004
PubMed ID: 15309026
Phosphatidylinositol 3-kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes.
Hoshino Y, Yokoo M, Yoshida N, Sasada H, Matsumoto H, Sato E
Mol Reprod Dev. 2004
PubMed ID: 15278907
In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent.
Guzeloglu Kayisli O, Kayisli UA, Luleci G, Arici A
Biol Reprod. 2004
PubMed ID: 15115729
Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation.
Xu J, Liao K
J Biol Chem. 2004
PubMed ID: 15192111
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.
Janes SM, Ofstad TA, Campbell DH, Watt FM, Prowse DM
J Cell Sci. 2004
PubMed ID: 15316080
The activity of the plexin-A1 receptor is regulated by Rac.
Turner LJ, Nicholls S, Hall A
J Biol Chem. 2004
PubMed ID: 15187088
RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation.
Vivarelli MS, McDonald D, Miller M, Cusson N, Kelliher M, Geha RS
J Exp Med. 2004
PubMed ID: 15280422
Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats.
Bitar MS, Wahid S, Pilcher CW, Al-Saleh E, Al-Mulla F
Horm Metab Res. 2004
PubMed ID: 15326564
Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway.
DeBusk LM, Hallahan DE, Lin PC
Exp Cell Res. 2004
PubMed ID: 15242771
Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination.
Ogata T, Iijima S, Hoshikawa S, Miura T, Yamamoto S, Oda H, Nakamura K, Tanaka S
J Neurosci. 2004
PubMed ID: 15282275
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins.
Bouchard C, Marquardt J, Brás A, Medema RH, Eilers M
EMBO J. 2004
PubMed ID: 15241468
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF
J Cell Biol. 2004
PubMed ID: 15249583
Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma.
Khor TO, Gul YA, Ithnin H, Seow HF
Cancer Lett. 2004
PubMed ID: 15183529
Reactive oxygen species mediate Endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 signaling, as well as protein synthesis, in vascular smooth muscle cells.
Daou GB, Srivastava AK
Free Radic Biol Med. 2004
PubMed ID: 15203192
GPx-1 modulates Akt and P70S6K phosphorylation and Gadd45 levels in MCF-7 cells.
Nasr MA, Fedele MJ, Esser K, Diamond AM
Free Radic Biol Med. 2004
PubMed ID: 15203190
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression.
Hou L, Klann E
J Neurosci. 2004
PubMed ID: 15254091
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations.
Baki L, Shioi J, Wen P, Shao Z, Schwarzman A, Gama-Sosa M, Neve R, Robakis NK
EMBO J. 2004
PubMed ID: 15192701
Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling.
Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, Koida M, Ogita K, Komori T
J Cell Biol. 2004
PubMed ID: 15226309
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway.
Lamothe B, Yamada M, Schaeper U, Birchmeier W, Lax I, Schlessinger J
Mol Cell Biol. 2004
PubMed ID: 15199124
EGF-dependent cell cycle progression is controlled by density-dependent regulation of Akt activation.
LeVea CM, Reeder JE, Mooney RA
Exp Cell Res. 2004
PubMed ID: 15194442
Ribosomal S6 kinase as a mediator of keratinocyte growth factor-induced activation of Akt in epithelial cells.
Pan ZZ, Devaux Y, Ray P
Mol Biol Cell. 2004
PubMed ID: 15107468
Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death.
Ono K, Iwanaga Y, Hirayama M, Kawamura T, Sowa N, Hasegawa K
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15020298
Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.
Gosmanov AR, Umpierrez GE, Karabell AH, Cuervo R, Thomason DB
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15010337
NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC.
Zhou FQ, Zhou J, Dedhar S, Wu YH, Snider WD
Neuron. 2004
PubMed ID: 15207235
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind JS
Clin Cancer Res. 2004
PubMed ID: 15217935
Akt decreases lymphocyte apoptosis and improves survival in sepsis.
Bommhardt U, Chang KC, Swanson PE, Wagner TH, Tinsley KW, Karl IE, Hotchkiss RS
J Immunol. 2004
PubMed ID: 15187138
Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation.
Sun L, Liu L, Yang XJ, Wu Z
J Cell Sci. 2004
PubMed ID: 15173318
AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9.
Chong ZZ, Kang JQ, Maiese K
Exp Cell Res. 2004
PubMed ID: 15149850
Role of the p70(S6K) pathway in regulating the actin cytoskeleton and cell migration.
Berven LA, Willard FS, Crouch MF
Exp Cell Res. 2004
PubMed ID: 15149849
Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis.
Jiang K, Sun J, Cheng J, Djeu JY, Wei S, Sebti S
Mol Cell Biol. 2004
PubMed ID: 15169915
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR
Nat Med. 2004
PubMed ID: 15156201
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
AKT participates in endothelial dysfunction in hypertension.
Iaccarino G, Ciccarelli M, Sorriento D, Cipolletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcucci O, Pastore L, Salvatore F, Condorelli G, Trimarco B
Circulation. 2004
PubMed ID: 15136501
Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, du Bois RM, Black CM, Leask A, Abraham DJ
Mol Biol Cell. 2004
PubMed ID: 15047866
Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.
Monick MM, Cameron K, Powers LS, Butler NS, McCoy D, Mallampalli RK, Hunninghake GW
Am J Respir Cell Mol Biol. 2004
PubMed ID: 14742298
Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia.
Abe T, Takagi N, Nakano M, Furuya M, Takeo S
Brain Res. 2004
PubMed ID: 15120593
LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway.
Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK
J Biol Chem. 2004
PubMed ID: 15047712
Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion.
Zhang HM, Rao JN, Guo X, Liu L, Zou T, Turner DJ, Wang JY
J Biol Chem. 2004
PubMed ID: 15024023
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.
Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, Imamura T, Kobayashi T, Tamura S, Olefsky JM, Kashiwagi A
J Biol Chem. 2004
PubMed ID: 15016818
Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes.
McConkey M, Gillin H, Webster CR, Anwer MS
J Biol Chem. 2004
PubMed ID: 15007074
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.
Ahn JY, Hu Y, Kroll TG, Allard P, Ye K
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15118108
Nitric oxide modulates murine yolk sac vasculogenesis and rescues glucose induced vasculopathy.
Nath AK, Enciso J, Kuniyasu M, Hao XY, Madri JA, Pinter E
Development. 2004
PubMed ID: 15128676
Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning.
Koponen E, Võikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castrén E
Mol Cell Neurosci. 2004
PubMed ID: 15121188
Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils.
Strassheim D, Asehnoune K, Park JS, Kim JY, He Q, Richter D, Kuhn K, Mitra S, Abraham E
J Immunol. 2004
PubMed ID: 15100319
A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse.
Kane LP, Mollenauer MN, Weiss A
J Immunol. 2004
PubMed ID: 15100285
Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis.
Liot G, Gabriel C, Cacquevel M, Ali C, MacKenzie ET, Buisson A, Vivien D
Exp Neurol. 2004
PubMed ID: 15081586
Exercise training attenuated the PKB and GSK-3 dephosphorylation in the myocardium of ZDF rats.
Lajoie C, Calderone A, Trudeau F, Lavoie N, Massicotte G, Gagnon S, Béliveau L
J Appl Physiol. 2004
PubMed ID: 14698990
G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses.
Zhu QS, Robinson LJ, Roginskaya V, Corey SJ
Blood. 2004
PubMed ID: 14656892
Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta.
Burchfield JG, Lennard AJ, Narasimhan S, Hughes WE, Wasinger VC, Corthals GL, Okuda T, Kondoh H, Biden TJ, Schmitz-Peiffer C
J Biol Chem. 2004
PubMed ID: 14985363
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.
Shiraishi I, Melendez J, Ahn Y, Skavdahl M, Murphy E, Welch S, Schaefer E, Walsh K, Rosenzweig A, Torella D, Nurzynska D, Kajstura J, Leri A, Anversa P, Sussman MA
Circ Res. 2004
PubMed ID: 14988230
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.
Cheng SW, Fryer LG, Carling D, Shepherd PR
J Biol Chem. 2004
PubMed ID: 14970221
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion.
Ahn JY, Rong R, Kroll TG, Van Meir EG, Snyder SH, Ye K
J Biol Chem. 2004
PubMed ID: 14761976
Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.
Yamamoto S, Tomita Y, Hoshida Y, Morooka T, Nagano H, Dono K, Umeshita K, Sakon M, Ishikawa O, Ohigashi H, Nakamori S, Monden M, Aozasa K
Clin Cancer Res. 2004
PubMed ID: 15102693
Active protein kinase B regulates TCR responsiveness by modulating cytoplasmic-nuclear localization of NFAT and NF-kappa B proteins.
Patra AK, Na SY, Bommhardt U
J Immunol. 2004
PubMed ID: 15067058
Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatment.
Matsuzaki H, Yamamoto T, Kikkawa U
Biochemistry. 2004
PubMed ID: 15065872
SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.
Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M
J Biol Chem. 2004
PubMed ID: 14744864
ARK5 is a tumor invasion-associated factor downstream of Akt signaling.
Suzuki A, Lu J, Kusakai G, Kishimoto A, Ogura T, Esumi H
Mol Cell Biol. 2004
PubMed ID: 15060171
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors.
Kwon HS, Huang B, Unterman TG, Harris RA
Diabetes. 2004
PubMed ID: 15047604
Physiological functions of protein kinase B/Akt.
Yang ZZ, Tschopp O, Baudry A, Dümmler B, Hynx D, Hemmings BA
Biochem Soc Trans. 2004
PubMed ID: 15046607
IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells.
Tuhácková Z, Sloncová E, Vojtechová M, Sovová V
Int J Mol Med. 2004
PubMed ID: 15010863
Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression.
Takemura Y, Fukuo K, Yasuda O, Inoue T, Inomata N, Yokoi T, Kawamoto H, Suhara T, Ogihara T
Hypertension. 2004
PubMed ID: 14967838
Ras GTPase-activating protein binds to Akt and is required for its activation.
Yue Y, Lypowy J, Hedhli N, Abdellatif M
J Biol Chem. 2004
PubMed ID: 14707121
Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis.
Sinha D, Bannergee S, Schwartz JH, Lieberthal W, Levine JS
J Biol Chem. 2004
PubMed ID: 14701865
Modulation of insulin effects on phosphorylation of protein kinase B and glycogen synthesis by tumor necrosis factor-alpha in HepG2 cells.
Gupta D, Khandelwal RL
Biochim Biophys Acta. 2004
PubMed ID: 15026145
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14985505
Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway.
Piccolo E, Vignati S, Maffucci T, Innominato PF, Riley AM, Potter BV, Pandolfi PP, Broggini M, Iacobelli S, Innocenti P, Falasca M
Oncogene. 2004
PubMed ID: 14755253
Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase/Akt pathway.
Aquila S, Sisci D, Gentile M, Middea E, Catalano S, Carpino A, Rago V, Andò S
J Clin Endocrinol Metab. 2004
PubMed ID: 15001646
Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer.
Vasko V, Saji M, Hardy E, Kruhlak M, Larin A, Savchenko V, Miyakawa M, Isozaki O, Murakami H, Tsushima T, Burman KD, De Micco C, Ringel MD
J Med Genet. 2004
PubMed ID: 14985374
Matrix metalloproteinase 1 interacts with neuronal integrins and stimulates dephosphorylation of Akt.
Conant K, St Hillaire C, Nagase H, Visse R, Gary D, Haughey N, Anderson C, Turchan J, Nath A
J Biol Chem. 2004
PubMed ID: 14679206
Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.
Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH
J Neurosci. 2004
PubMed ID: 14973226
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate.
Vitari AC, Deak M, Collins BJ, Morrice N, Prescott AR, Phelan A, Humphreys S, Alessi DR
Biochem J. 2004
PubMed ID: 14611643
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP).
Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, Wang HG, Tsang BK, Cheng JQ
J Biol Chem. 2004
PubMed ID: 14645242
Estrogen elicits cytochrome P450--mediated flow-induced dilation of arterioles in NO deficiency: role of PI3K-Akt phosphorylation in genomic regulation.
Huang A, Sun D, Wu Z, Yan C, Carroll MA, Jiang H, Falck JR, Kaley G
Circ Res. 2004
PubMed ID: 14670845
Akt activation in platelets depends on Gi signaling pathways.
Kim S, Jin J, Kunapuli SP
J Biol Chem. 2004
PubMed ID: 14623889
Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt.
Kanda S, Miyata Y, Kanetake H
J Biol Chem. 2004
PubMed ID: 14610089
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
Nofer JR, van der Giet M, Tölle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Gödecke A, Ishii I, Kleuser B, Schäfers M, Fobker M, Zidek W, Assmann G, Chun J, Levkau B
J Clin Invest. 2004
PubMed ID: 14966566
Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2.
Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF
J Clin Invest. 2004
PubMed ID: 14755341
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate.
Vadlamudi RK, Li F, Barnes CJ, Bagheri-Yarmand R, Kumar R
EMBO Rep. 2004
PubMed ID: 14749719
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.
Jaffe AB, Aspenström P, Hall A
Mol Cell Biol. 2004
PubMed ID: 14749388
Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins.
Roberts MS, Woods AJ, Dale TC, Van Der Sluijs P, Norman JC
Mol Cell Biol. 2004
PubMed ID: 14749368
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
Remy I, Michnick SW
Mol Cell Biol. 2004
PubMed ID: 14749367
Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells.
Gong L, Unnikrishnan I, Raghavan A, Parmar K, Rosenberg N
J Virol. 2004
PubMed ID: 14747529
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia.
Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA
Nat Genet. 2004
PubMed ID: 14745448
The costimulation-regulated duration of PKB activation controls T cell longevity.
Song J, Salek-Ardakani S, Rogers PR, Cheng M, Van Parijs L, Croft M
Nat Immunol. 2004
PubMed ID: 14730361
Role for the pleckstrin homology domain-containing protein CKIP-1 in phosphatidylinositol 3-kinase-regulated muscle differentiation.
Safi A, Vandromme M, Caussanel S, Valdacci L, Baas D, Vidal M, Brun G, Schaeffer L, Goillot E
Mol Cell Biol. 2004
PubMed ID: 14729969
S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).
Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y
FASEB J. 2004
PubMed ID: 14657000
Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations.
Ryder J, Su Y, Ni B
Cell Signal. 2004
PubMed ID: 14636889
Permissive roles of phosphatidyl inositol 3-kinase and Akt in skeletal myocyte maturation.
Wilson EM, Tureckova J, Rotwein P
Mol Biol Cell. 2004
PubMed ID: 14595115
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
Chandrasekar B, Bysani S, Mummidi S
J Biol Chem. 2004
PubMed ID: 14625285
fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo.
Dubrulle J, Pourquié O
Nature. 2004
PubMed ID: 14749824
Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.
West KA, Linnoila IR, Belinsky SA, Harris CC, Dennis PA
Cancer Res. 2004
PubMed ID: 14744754
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway.
Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I
EMBO J. 2004
PubMed ID: 14713953
AKT/protein kinase B regulation of BCL family members during oxysterol-induced apoptosis.
Rusiñol AE, Thewke D, Liu J, Freeman N, Panini SR, Sinensky MS
J Biol Chem. 2004
PubMed ID: 14559920
SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells.
Wang X, Chen L, Maures TJ, Herrington J, Carter-Su C
J Biol Chem. 2004
PubMed ID: 14565960
Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT.
Kyoung Pyo H, Lovati E, Pasinetti GM, Ksiezak-Reding H
Neuroscience. 2004
PubMed ID: 15283964
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Tyrosine phosphorylation-dependent PI 3 kinase/Akt signal transduction regulates TGFbeta-induced fibronectin expression in mesangial cells.
Ghosh Choudhury G, Abboud HE
Cell Signal. 2004
PubMed ID: 14607273
Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.
Liu S, Premont RT, Kontos CD, Huang J, Rockey DC
J Biol Chem. 2003
PubMed ID: 14523027
Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway.
Fornaro M, Plescia J, Chheang S, Tallini G, Zhu YM, King M, Altieri DC, Languino LR
J Biol Chem. 2003
PubMed ID: 14523021
Glutaredoxin exerts an antiapoptotic effect by regulating the redox state of Akt.
Murata H, Ihara Y, Nakamura H, Yodoi J, Sumikawa K, Kondo T
J Biol Chem. 2003
PubMed ID: 14522978
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.
Gines S, Ivanova E, Seong IS, Saura CA, MacDonald ME
J Biol Chem. 2003
PubMed ID: 14522959
Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.
Bae SS, Cho H, Mu J, Birnbaum MJ
J Biol Chem. 2003
PubMed ID: 14522993
Pten dose dictates cancer progression in the prostate.
Trotman LC, Niki M, Dotan ZA, Koutcher JA, Di Cristofano A, Xiao A, Khoo AS, Roy-Burman P, Greenberg NM, Van Dyke T, Cordon-Cardo C, Pandolfi PP
PLoS Biol. 2003
PubMed ID: 14691534
Incidence, mechanism and prognostic value of activated AKT in pancreas cancer.
Schlieman MG, Fahy BN, Ramsamooj R, Beckett L, Bold RJ
Br J Cancer. 2003
PubMed ID: 14647146
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement.
Ono H, Shimano H, Katagiri H, Yahagi N, Sakoda H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Viana AY, Fukushima Y, Abe M, Shojima N, Kikuchi M, Yamada N, Oka Y, Asano T
Diabetes. 2003
PubMed ID: 14633850
HER2/neu uses Akt to suppress retinoic acid response element binding activity in MDA-MB-453 breast cancer cells.
Siwak DR, Mendoza-Gamboa E, Tari AM
Int J Oncol. 2003
PubMed ID: 14612949
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.
Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, Thaisz J, Drusco A, Croce C, Sadoshima J, Condorelli G, Vatner SF
J Biol Chem. 2003
PubMed ID: 13129932
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Increase of AKT/PKB expression correlates with gleason pattern in human prostate cancer.
Liao Y, Grobholz R, Abel U, Trojan L, Michel MS, Angel P, Mayer D
Int J Cancer. 2003
PubMed ID: 14520710
Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes.
Wang HQ, Quan T, He T, Franke TF, Voorhees JJ, Fisher GJ
J Biol Chem. 2003
PubMed ID: 12952968
Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells.
Adachi M, Katsumura KR, Fujii K, Kobayashi S, Aoki H, Matsuzaki M
FEBS Lett. 2003
PubMed ID: 14596918
RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development.
Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE
Genes Dev. 2003
PubMed ID: 14597666
Expression and localization of total Akt1 and phosphorylated Akt1 in the rat seminiferous epithelium.
Hixon ML, Boekelheide K
J Androl. 2003
PubMed ID: 14581516
Germline inactivation of PTEN and dysregulation of the phosphoinositol-3-kinase/Akt pathway cause human Lhermitte-Duclos disease in adults.
Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C
Am J Hum Genet. 2003
PubMed ID: 14566704
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.
Powell DJ, Hajduch E, Kular G, Hundal HS
Mol Cell Biol. 2003
PubMed ID: 14560023
Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR, Van Aalten DM
Biochem J. 2003
PubMed ID: 12964941
Akt signaling in skeletal muscle: regulation by exercise and passive stretch.
Sakamoto K, Aschenbach WG, Hirshman MF, Goodyear LJ
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12837666
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner.
Debnath J, Walker SJ, Brugge JS
J Cell Biol. 2003
PubMed ID: 14568991
Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAPK activation.
Christian SL, Lee RL, McLeod SJ, Burgess AE, Li AH, Dang-Lawson M, Lin KB, Gold MR
J Biol Chem. 2003
PubMed ID: 12904304
Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells.
Ciechomska I, Pyrzynska B, Kazmierczak P, Kaminska B
Oncogene. 2003
PubMed ID: 14576824
Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion.
Howes AL, Arthur JF, Zhang T, Miyamoto S, Adams JW, Dorn II GW, Woodcock EA, Brown JH
J Biol Chem. 2003
PubMed ID: 12900409
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart.
Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR
J Biol Chem. 2003
PubMed ID: 12890675
Reciprocal regulation of MelCAM and AKT in human melanoma.
Li G, Kalabis J, Xu X, Meier F, Oka M, Bogenrieder T, Herlyn M
Oncogene. 2003
PubMed ID: 14534536
Akt signaling regulates side population cell phenotype via Bcrp1 translocation.
Mogi M, Yang J, Lambert JF, Colvin GA, Shiojima I, Skurk C, Summer R, Fine A, Quesenberry PJ, Walsh K
J Biol Chem. 2003
PubMed ID: 12851395
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.
Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ
J Clin Invest. 2003
PubMed ID: 14561707
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.
Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB
Mol Cell Biol. 2003
PubMed ID: 14517300
Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.
Shenoy NG, Gleich GJ, Thomas LL
J Immunol. 2003
PubMed ID: 14500673
Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA
Exp Cell Res. 2003
PubMed ID: 14499622
Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis.
Liao Y, Hung MC
Mol Cell Biol. 2003
PubMed ID: 12972603
Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.
Müller C, Dünschede F, Koch E, Vollmar AM, Kiemer AK
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12816756
Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids.
Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH
J Biol Chem. 2003
PubMed ID: 12865424
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Umans L, Vermeire L, Francis A, Chang H, Huylebroeck D, Zwijsen A
Genesis. 2003
PubMed ID: 14502571
Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer.
Zhang G, He B, Weber GF
Mol Cell Biol. 2003
PubMed ID: 12944477
Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors.
Sugatani T, Alvarez UM, Hruska KA
J Cell Biochem. 2003
PubMed ID: 12938156
Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1.
Gagnon V, St-Germain ME, Parent S, Asselin E
Int J Oncol. 2003
PubMed ID: 12888921
OxLDL induces mitogen-activated protein kinase activation mediated via PI3-kinase/Akt in vascular smooth muscle cells.
Chien MW, Chien CS, Hsiao LD, Lin CH, Yang CM
J Lipid Res. 2003
PubMed ID: 12810818
Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.
Sans MD, DiMagno MJ, D'Alecy LG, Williams JA
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12773302
Akt negatively regulates translation of the ternary complex factor Elk-1.
Figueroa C, Vojtek AB
Oncogene. 2003
PubMed ID: 12944902
Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
Yang ZZ, Tschopp O, Hemmings-Mieszczak M, Feng J, Brodbeck D, Perentes E, Hemmings BA
J Biol Chem. 2003
PubMed ID: 12783884
JNK-interacting protein 1 promotes Akt1 activation.
Kim AH, Sasaki T, Chao MV
J Biol Chem. 2003
PubMed ID: 12783873
The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration.
Santoro MM, Gaudino G, Marchisio PC
Dev Cell. 2003
PubMed ID: 12919677
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
Rathmell JC, Elstrom RL, Cinalli RM, Thompson CB
Eur J Immunol. 2003
PubMed ID: 12884297
Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
Lennartsson J, Wernstedt C, Engström U, Hellman U, Rönnstrand L
Exp Cell Res. 2003
PubMed ID: 12878163
Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.
Na SY, Patra A, Scheuring Y, Marx A, Tolaini M, Kioussis D, Hemmings BA, Hemmings B, Hünig T, Bommhardt U
J Immunol. 2003
PubMed ID: 12874217
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.
Fox CJ, Hammerman PS, Cinalli RM, Master SR, Chodosh LA, Thompson CB
Genes Dev. 2003
PubMed ID: 12869584
CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins.
Doong H, Rizzo K, Fang S, Kulpa V, Weissman AM, Kohn EC
J Biol Chem. 2003
PubMed ID: 12750378
14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase.
Pozuelo Rubio M, Peggie M, Wong BH, Morrice N, MacKintosh C
EMBO J. 2003
PubMed ID: 12853467
Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.
Ramljak D, Coticchia CM, Nishanian TG, Saji M, Ringel MD, Conzen SD, Dickson RB
Exp Cell Res. 2003
PubMed ID: 12837294
Differing roles of Akt and serum- and glucocorticoid-regulated kinase in glucose metabolism, DNA synthesis, and oncogenic activity.
Sakoda H, Gotoh Y, Katagiri H, Kurokawa M, Ono H, Onishi Y, Anai M, Ogihara T, Fujishiro M, Fukushima Y, Abe M, Shojima N, Kikuchi M, Oka Y, Hirai H, Asano T
J Biol Chem. 2003
PubMed ID: 12734207
Putative phosphatidylinositol 3-kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt activation.
Liu SL, Lerman MI, Miller AD
J Virol. 2003
PubMed ID: 12829832
Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action.
Trencia A, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, Santopietro S, Giacco F, Condorelli G, Formisano P, Beguinot F
Mol Cell Biol. 2003
PubMed ID: 12808093
Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.
Vojtek AB, Taylor J, DeRuiter SL, Yu JY, Figueroa C, Kwok RP, Turner DL
Mol Cell Biol. 2003
PubMed ID: 12808085
Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a phosphatidylinositol 3-kinase (PI3) kinase-dependent manner in Neuro2a cells.
van der Heide LP, Hoekman MF, Biessels GJ, Gispen WH
J Neurochem. 2003
PubMed ID: 12807428
Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin.
Borgatti P, Martelli AM, Tabellini G, Bellacosa A, Capitani S, Neri LM
J Cell Physiol. 2003
PubMed ID: 12767043
Control of synaptic strength, a novel function of Akt.
Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Lu J, Wang Y, Liu F, Wang YT
Neuron. 2003
PubMed ID: 12818177
Regulation of Akt expression and phosphorylation by 17beta-estradiol in the rat uterus during estrous cycle.
Dery MC, Leblanc V, Shooner C, Asselin E
Reprod Biol Endocrinol. 2003
PubMed ID: 12816542
TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.
Du K, Herzig S, Kulkarni RN, Montminy M
Science. 2003
PubMed ID: 12791994
Adrenomedullin provokes endothelial Akt activation and promotes vascular regeneration both in vitro and in vivo.
Miyashita K, Itoh H, Sawada N, Fukunaga Y, Sone M, Yamahara K, Yurugi-Kobayashi T, Park K, Nakao K
FEBS Lett. 2003
PubMed ID: 12782295
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.
Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, Jacobs J, Sundararajan D, Chen WS, Crawford SE, Coleman KG, Hay N
Genes Dev. 2003
PubMed ID: 12782654
Deconstructing phosphatases in limb development.
Dudley AT, Tabin CJ
Nat Cell Biol. 2003
PubMed ID: 12776124
Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos.
Stenvers KL, Tursky ML, Harder KW, Kountouri N, Amatayakul-Chantler S, Grail D, Small C, Weinberg RA, Sizeland AM, Zhu HJ
Mol Cell Biol. 2003
PubMed ID: 12773577
Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway.
Nair P, Somasundaram K, Krishna S
J Virol. 2003
PubMed ID: 12768030
MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb.
Kawakami Y, Rodríguez-León J, Koth CM, Büscher D, Itoh T, Raya A, Ng JK, Esteban CR, Takahashi S, Henrique D, Schwarz MF, Asahara H, Izpisúa Belmonte JC
Nat Cell Biol. 2003
PubMed ID: 12766772
EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland.
Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW
Dev Dyn. 2003
PubMed ID: 12761849
The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.
Shimamura H, Terada Y, Okado T, Tanaka H, Inoshita S, Sasaki S
J Am Soc Nephrol. 2003
PubMed ID: 12761242
Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation.
Abraham E, Gyetko MR, Kuhn K, Arcaroli J, Strassheim D, Park JS, Shetty S, Idell S
J Immunol. 2003
PubMed ID: 12759445
Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.
Pongracz J, Parnell S, Anderson G, Jaffrézou JP, Jenkinson E
Mol Immunol. 2003
PubMed ID: 12749908
Apoptosis and activation of Erkl/2 and Akt in astrocytes postischemia.
Jiang Z, Zhang Y, Chen XQ, Lam PY, Yang H, Xu Q, Yu AC
Neurochem Res. 2003
PubMed ID: 12718435
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R
Nat Immunol. 2003
PubMed ID: 12717433
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.
Chen HK, Fernandez-Funez P, Acevedo SF, Lam YC, Kaytor MD, Fernandez MH, Aitken A, Skoulakis EM, Orr HT, Botas J, Zoghbi HY
Cell. 2003
PubMed ID: 12757707
Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.
Pankov R, Cukierman E, Clark K, Matsumoto K, Hahn C, Poulin B, Yamada KM
J Biol Chem. 2003
PubMed ID: 12637511
Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils.
Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, McLeish KR
J Immunol. 2003
PubMed ID: 12734380
APPL suppresses androgen receptor transactivation via potentiating Akt activity.
Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C
J Biol Chem. 2003
PubMed ID: 12621049
Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
Emamian ES, Kaytor MD, Duvick LA, Zu T, Tousey SK, Zoghbi HY, Clark HB, Orr HT
Neuron. 2003
PubMed ID: 12741986
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.
Grille SJ, Bellacosa A, Upson J, Klein-Szanto AJ, van Roy F, Lee-Kwon W, Donowitz M, Tsichlis PN, Larue L
Cancer Res. 2003
PubMed ID: 12727836
Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt.
Gu J, Nada S, Okada M, Sekiguchi K
Biochem Biophys Res Commun. 2003
PubMed ID: 12670507
Akt activation promotes degradation of tuberin and FOXO3a via the proteasome.
Plas DR, Thompson CB
J Biol Chem. 2003
PubMed ID: 12517744
Integrin-linked kinase regulates chondrocyte shape and proliferation.
Grashoff C, Aszódi A, Sakai T, Hunziker EB, Fässler R
EMBO Rep. 2003
PubMed ID: 12671688
Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, extracellular signal-regulated kinase 2, and p90 ribosomal S6 kinase 2 but not mitogen- and stress-activated protein kinase 1.
He Z, Ma WY, Liu G, Zhang Y, Bode AM, Dong Z
J Biol Chem. 2003
PubMed ID: 12529330
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.
Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier AM, Kahn CR, Benito M
J Biol Chem. 2003
PubMed ID: 12525499
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.
Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA
J Biol Chem. 2003
PubMed ID: 12524439
Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling.
Zhang D, Brodt P
Oncogene. 2003
PubMed ID: 12592384
Akt as a mediator of secretory phospholipase A2 receptor-involved inducible nitric oxide synthase expression.
Park DW, Kim JR, Kim SY, Sonn JK, Bang OS, Kang SS, Kim JH, Baek SH
J Immunol. 2003
PubMed ID: 12574380
Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.
Haendeler J, Hoffmann J, Rahman S, Zeiher AM, Dimmeler S
FEBS Lett. 2003
PubMed ID: 12586360
Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO.
Li F, Omori N, Jin G, Wang SJ, Sato K, Nagano I, Shoji M, Abe K
Brain Res. 2003
PubMed ID: 12543452
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.
Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A
J Biol Chem. 2003
PubMed ID: 12458207
The DNA sequence and analysis of human chromosome 14.
Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Brüls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Ségurens B, Anière F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Ménard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufossé-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guérin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quétier F, Waterston R, Hood L, Weissenbach J
Nature. 2003
PubMed ID: 12508121
Constitutively active Akt1 protects HL60 leukemia cells from TRAIL-induced apoptosis through a mechanism involving NF-kappaB activation and cFLIP(L) up-regulation.
Bortul R, Tazzari PL, Cappellini A, Tabellini G, Billi AM, Bareggi R, Manzoli L, Cocco L, Martelli AM
Leukemia. 2003
PubMed ID: 12592338
Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia.
Fuhler GM, Drayer AL, Vellenga E
Blood. 2003
PubMed ID: 12529294
Normal function of HERG K+ channels expressed in HEK293 cells requires basal protein kinase B activity.
Zhang Y, Wang H, Wang J, Han H, Nattel S, Wang Z
FEBS Lett. 2003
PubMed ID: 12527373
Ligand- and kinase activity-independent cell survival mediated by the epidermal growth factor receptor expressed in 32D cells.
Ewald JA, Wilkinson JC, Guyer CA, Staros JV
Exp Cell Res. 2003
PubMed ID: 12531698
Akt phosphorylation and cell survival after hypoxia-induced cytochrome c release in superfused respiring neonatal rat cerebrocortical slices.
Hirai K, Hayashi T, Chan PH, Basus VJ, James TL, Litt L
Acta Neurochir Suppl. 2003
PubMed ID: 14753441
Intrinsic activation of PI3K/Akt signaling pathway and its neuroprotective effect against retinal injury.
Nakazawa T, Shimura M, Tomita H, Akiyama H, Yoshioka Y, Kudou H, Tamai M
Curr Eye Res. 2003
PubMed ID: 12789537
[EGF-induced signal transduction in clonal cells of epidermoid carcinoma A431]
Grudinkin PS, Bagaeva VV, Nikol'skiĭ NN
Tsitologiia. 2003
PubMed ID: 12722480
Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity.
Pituch-Noworolska A, Majka M, Janowska-Wieczorek A, Baj-Krzyworzeka M, Urbanowicz B, Malec E, Ratajczak MZ
Folia Histochem Cytobiol. 2003
PubMed ID: 12705474
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
Basu S, Totty NF, Irwin MS, Sudol M, Downward J
Mol Cell. 2003
PubMed ID: 12535517
Transendothelial migration leads to protection from starvation-induced apoptosis in CD34+CD14+ circulating precursors: evidence for PECAM-1 involvement through Akt/PKB activation.
Ferrero E, Belloni D, Contini P, Foglieni C, Ferrero ME, Fabbri M, Poggi A, Zocchi MR
Blood. 2003
PubMed ID: 12393747
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.
Beffert U, Morfini G, Bock HH, Reyna H, Brady ST, Herz J
J Biol Chem. 2002
PubMed ID: 12376533
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Role of phosphatidylinositol 3-kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells.
Isenovic ER, Meng Y, Divald A, Milivojevic N, Sowers JR
Endocrine. 2002
PubMed ID: 12624428
Activation of ERK and Akt signaling in focal cerebral ischemia: modulation by TGF-alpha and involvement of NMDA receptor.
Friguls B, Petegnief V, Justicia C, Pallàs M, Planas AM
Neurobiol Dis. 2002
PubMed ID: 12586553
Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N
Mol Cell Biol. 2002
PubMed ID: 12446789
Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis.
Rokudai S, Fujita N, Kitahara O, Nakamura Y, Tsuruo T
Mol Cell Biol. 2002
PubMed ID: 12446787
Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells.
Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z
Mol Cell Biol. 2002
PubMed ID: 12446767
14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).
Liu MY, Cai S, Espejo A, Bedford MT, Walker CL
Cancer Res. 2002
PubMed ID: 12438239
The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells.
Crean JK, Finlay D, Murphy M, Moss C, Godson C, Martin F, Brady HR
J Biol Chem. 2002
PubMed ID: 12218048
The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.
Valdés F, Alvarez AM, Locascio A, Vega S, Herrera B, Fernández M, Benito M, Nieto MA, Fabregat I
Mol Cancer Res. 2002
PubMed ID: 12496370
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.
Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N
J Biol Chem. 2002
PubMed ID: 12176997
Dopamine induces a PI3-kinase-independent activation of Akt in striatal neurons: a new route to cAMP response element-binding protein phosphorylation.
Brami-Cherrier K, Valjent E, Garcia M, Pagès C, Hipskind RA, Caboche J
J Neurosci. 2002
PubMed ID: 12388598
Binding of protein kinase B to the plakin family member periplakin.
van den Heuvel AP, de Vries-Smits AM, van Weeren PC, Dijkers PF, de Bruyn KM, Riedl JA, Burgering BM
J Cell Sci. 2002
PubMed ID: 12244133
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase.
Conus NM, Hannan KM, Cristiano BE, Hemmings BA, Pearson RB
J Biol Chem. 2002
PubMed ID: 12149249
IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines.
Haller D, Russo MP, Sartor RB, Jobin C
J Biol Chem. 2002
PubMed ID: 12140289
Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway.
Allen MP, Xu M, Linseman DA, Pawlowski JE, Bokoch GM, Heidenreich KA, Wierman ME
J Biol Chem. 2002
PubMed ID: 12138087
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status.
Shiojima I, Yefremashvili M, Luo Z, Kureishi Y, Takahashi A, Tao J, Rosenzweig A, Kahn CR, Abel ED, Walsh K
J Biol Chem. 2002
PubMed ID: 12163490
Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.
Di-Poï N, Tan NS, Michalik L, Wahli W, Desvergne B
Mol Cell. 2002
PubMed ID: 12419217
Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth.
Taniyama Y, Walsh K
J Mol Cell Cardiol. 2002
PubMed ID: 12392981
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M
Nat Med. 2002
PubMed ID: 12244303
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest.
Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM
Nat Med. 2002
PubMed ID: 12244302
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL
Nat Med. 2002
PubMed ID: 12244301
IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway.
Yoo JK, Cho JH, Lee SW, Sung YC
J Immunol. 2002
PubMed ID: 12244155
Direct identification of PTEN phosphorylation sites.
Miller SJ, Lou DY, Seldin DC, Lane WS, Neel BG
FEBS Lett. 2002
PubMed ID: 12297295
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.
Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ
J Biol Chem. 2002
PubMed ID: 12167664
The role of Asp-462 in regulating Akt activity.
Xu J, Liu D, Songyang Z
J Biol Chem. 2002
PubMed ID: 12124386
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12237475
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.
Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM
J Biol Chem. 2002
PubMed ID: 12107176
Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.
Kim YB, Shulman GI, Kahn BB
J Biol Chem. 2002
PubMed ID: 12095990
cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b.
Lou L, Urbani J, Ribeiro-Neto F, Altschuler DL
J Biol Chem. 2002
PubMed ID: 12089143
Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.
Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, Choudhury GG
J Biol Chem. 2002
PubMed ID: 12084724
Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes.
Decraene D, Agostinis P, Bouillon R, Degreef H, Garmyn M
J Biol Chem. 2002
PubMed ID: 12070137
Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.
Cui TX, Nakagami H, Nahmias C, Shiuchi T, Takeda-Matsubara Y, Li JM, Wu L, Iwai M, Horiuchi M
Mol Endocrinol. 2002
PubMed ID: 12198247
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Scheid MP, Marignani PA, Woodgett JR
Mol Cell Biol. 2002
PubMed ID: 12167717
Akt1 regulates a JNK scaffold during excitotoxic apoptosis.
Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum MJ, Chao MV
Neuron. 2002
PubMed ID: 12194869
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
Fujita N, Sato S, Katayama K, Tsuruo T
J Biol Chem. 2002
PubMed ID: 12042314
ACTH promotion of p27(Kip1) induction in mouse Y1 adrenocortical tumor cells is dependent on both PKA activation and Akt/PKB inactivation.
Forti FL, Schwindt TT, Moraes MS, Eichler CB, Armelin HA
Biochemistry. 2002
PubMed ID: 12146978
Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer.
De Miguel MP, Cheng L, Holland EC, Federspiel MJ, Donovan PJ
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12140361
Akt mediates the anti-apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule cells.
Lafon-Cazal M, Perez V, Bockaert J, Marin P
Eur J Neurosci. 2002
PubMed ID: 12270033
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase.
Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C
EMBO J. 2002
PubMed ID: 12145204
Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.
Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A
Mol Cell Biol. 2002
PubMed ID: 12138205
Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells.
Oki S, Limnander A, Danial NN, Rothman PB
Blood. 2002
PubMed ID: 12130510
Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt.
Kim B, Feldman EL
J Biol Chem. 2002
PubMed ID: 12011046
High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate.
Thomas CC, Deak M, Alessi DR, van Aalten DM
Curr Biol. 2002
PubMed ID: 12176338
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.
Hill MM, Feng J, Hemmings BA
Curr Biol. 2002
PubMed ID: 12176337
Phagocytosis of apoptotic cells by macrophages induces novel signaling events leading to cytokine-independent survival and inhibition of proliferation: activation of Akt and inhibition of extracellular signal-regulated kinases 1 and 2.
Reddy SM, Hsiao KH, Abernethy VE, Fan H, Longacre A, Lieberthal W, Rauch J, Koh JS, Levine JS
J Immunol. 2002
PubMed ID: 12097372
HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.
Deregibus MC, Cantaluppi V, Doublier S, Brizzi MF, Deambrosis I, Albini A, Camussi G
J Biol Chem. 2002
PubMed ID: 11994280
A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification.
Pallafacchina G, Calabria E, Serrano AL, Kalhovde JM, Schiaffino S
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12084817
Inhibition of interleukin-1beta -induced NF-kappa B activation by calcium/calmodulin-dependent protein kinase kinase occurs through Akt activation associated with interleukin-1 receptor-associated kinase phosphorylation and uncoupling of MyD88.
Chen BC, Wu WT, Ho FM, Lin WW
J Biol Chem. 2002
PubMed ID: 11976320
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC
Mol Cell. 2002
PubMed ID: 12150915
Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake.
Edinger AL, Thompson CB
Mol Biol Cell. 2002
PubMed ID: 12134068
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.
Marino S, Krimpenfort P, Leung C, van der Korput HA, Trapman J, Camenisch I, Berns A, Brandner S
Development. 2002
PubMed ID: 12091320
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation.
Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E, Mustelin T
J Immunol. 2002
PubMed ID: 12077256
Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth.
Takahashi A, Kureishi Y, Yang J, Luo Z, Guo K, Mukhopadhyay D, Ivashchenko Y, Branellec D, Walsh K
Mol Cell Biol. 2002
PubMed ID: 12052887
Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice.
Shibata M, Yamawaki T, Sasaki T, Hattori H, Hamada J, Fukuuchi Y, Okano H, Miura M
Brain Res. 2002
PubMed ID: 12031847
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
Kane S, Sano H, Liu SC, Asara JM, Lane WS, Garner CC, Lienhard GE
J Biol Chem. 2002
PubMed ID: 11994271
Transcriptional effects of chronic Akt activation in the heart.
Cook SA, Matsui T, Li L, Rosenzweig A
J Biol Chem. 2002
PubMed ID: 11956204
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart.
Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A
J Biol Chem. 2002
PubMed ID: 11943770
Identification of 14-3-3zeta as a protein kinase B/Akt substrate.
Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR
J Biol Chem. 2002
PubMed ID: 11956222
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y
J Biol Chem. 2002
PubMed ID: 11923280
A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle.
Shtivelman E, Sussman J, Stokoe D
Curr Biol. 2002
PubMed ID: 12062056
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
Humbert S, Bryson EA, Cordelières FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F
Dev Cell. 2002
PubMed ID: 12062094
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H
Mol Cell Biol. 2002
PubMed ID: 11997518
Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway.
Conejo R, de Alvaro C, Benito M, Cuadrado A, Lorenzo M
Oncogene. 2002
PubMed ID: 12032842
A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane.
French SW, Shen RR, Koh PJ, Malone CS, Mallick P, Teitell MA
Biochemistry. 2002
PubMed ID: 12009899
UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.
Moriarity JL, Hurt KJ, Resnick AC, Storm PB, Laroy W, Schnaar RL, Snyder SH
J Biol Chem. 2002
PubMed ID: 11877387
Upregulation of phosphoinositide 3-kinase and protein kinase B in alveolar macrophages following ozone inhalation. Role of NF-kappaB and STAT-1 in ozone-induced nitric oxide production and toxicity.
Laskin DL, Fakhrzadeh L, Heck DE, Gerecke D, Laskin JD
Mol Cell Biochem. 2002
PubMed ID: 12162464
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Sordella R, Classon M, Hu KQ, Matheson SF, Brouns MR, Fine B, Zhang L, Takami H, Yamada Y, Settleman J
Dev Cell. 2002
PubMed ID: 12015964
The protein kinase B/Akt signalling pathway in human malignancy.
Nicholson KM, Anderson NG
Cell Signal. 2002
PubMed ID: 11882383
Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI.
Barry FA, Gibbins JM
J Biol Chem. 2002
PubMed ID: 11825911
Contraction regulation of Akt in rat skeletal muscle.
Sakamoto K, Hirshman MF, Aschenbach WG, Goodyear LJ
J Biol Chem. 2002
PubMed ID: 11809761
Akt phosphorylation and neuronal survival after traumatic brain injury in mice.
Noshita N, Lewén A, Sugawara T, Chan PH
Neurobiol Dis. 2002
PubMed ID: 11950275
Akt/protein kinase B promotes organ growth in transgenic mice.
Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S
Mol Cell Biol. 2002
PubMed ID: 11909972
Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.
Cartel NJ, Wang J, Post M
Biochem J. 2002
PubMed ID: 11903042
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB
Mol Cell Biol. 2002
PubMed ID: 11884598
AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival.
Li Y, Dowbenko D, Lasky LA
J Biol Chem. 2002
PubMed ID: 11756412
Phosphorylation of HDM2 by Akt.
Ashcroft M, Ludwig RL, Woods DB, Copeland TD, Weber HO, MacRae EJ, Vousden KH
Oncogene. 2002
PubMed ID: 11960368
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.
Hurt KJ, Musicki B, Palese MA, Crone JK, Becker RE, Moriarity JL, Snyder SH, Burnett AL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11904450
Immunohistochemical localization of phosphorylated AKT in multiple myeloma.
Alkan S, Izban KF
Blood. 2002
PubMed ID: 11902142
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
Liu G, Zhang Y, Bode AM, Ma WY, Dong Z
J Biol Chem. 2002
PubMed ID: 11777913
Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts.
Sumitani S, Goya K, Testa JR, Kouhara H, Kasayama S
Endocrinology. 2002
PubMed ID: 11861503
Phosphorylation of Fanconi anemia protein, FANCA, is regulated by Akt kinase.
Otsuki T, Nagashima T, Komatsu N, Kirito K, Furukawa Y, Kobayashi Si S, Liu JM, Ozawa K
Biochem Biophys Res Commun. 2002
PubMed ID: 11855836
Identification of Akt association and oligomerization domains of the Akt kinase coactivator TCL1.
Künstle G, Laine J, Pierron G, Kagami Si S, Nakajima H, Hoh F, Roumestand C, Stern MH, Noguchi M
Mol Cell Biol. 2002
PubMed ID: 11839817
Absence of mutations in the pleckstrin homology (PH) domain of protein kinase B (PKB/Akt) in malignant melanoma.
Waldmann V, Wacker J, Deichmann M
Melanoma Res. 2002
PubMed ID: 11828257
Role for the adaptor protein Grb10 in the activation of Akt.
Jahn T, Seipel P, Urschel S, Peschel C, Duyster J
Mol Cell Biol. 2002
PubMed ID: 11809791
Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest.
Bourbon NA, Sandirasegarane L, Kester M
J Biol Chem. 2002
PubMed ID: 11723139
Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.
Laine J, Künstle G, Obata T, Noguchi M
J Biol Chem. 2002
PubMed ID: 11707444
Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways.
Zhang L, Li B, Ma W, Barker JL, Chang YH, Zhao W, Rubinow DR
Brain Res Mol Brain Res. 2002
PubMed ID: 11834296
Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation.
Park HS, Kim MS, Huh SH, Park J, Chung J, Kang SS, Choi EJ
J Biol Chem. 2002
PubMed ID: 11707464
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.
Lynch DK, Daly RJ
EMBO J. 2002
PubMed ID: 11782427
IL-2 and related cytokines can promote T cell survival by activating AKT.
Kelly E, Won A, Refaeli Y, Van Parijs L
J Immunol. 2002
PubMed ID: 11777951
Different cellular localization, translocation, and insulin-induced phosphorylation of PKBalpha in HepG2 cells and hepatocytes.
Syed NA, Horner KN, Misra V, Khandelwal RL
J Cell Biochem. 2002
PubMed ID: 12112022
AR and ER interaction with a p21-activated kinase (PAK6).
Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP
Mol Endocrinol. 2002
PubMed ID: 11773441
Skin-derived nerve growth factor blocks programmed cell death in the trigeminal ganglia but does not enhance neuron proliferation.
Figueiredo HF, Davis BM, Albers KM
Mech Dev. 2001
PubMed ID: 11731234
Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451.
De Ruiter ND, Burgering BM, Bos JL
Mol Cell Biol. 2001
PubMed ID: 11689711
Molecular basis of mature T-cell leukemia.
Pekarsky Y, Hallas C, Croce CM
JAMA. 2001
PubMed ID: 11710897
Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor.
Hellyer NJ, Kim MS, Koland JG
J Biol Chem. 2001
PubMed ID: 11546794
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.
Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC
Nat Cell Biol. 2001
PubMed ID: 11715018
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M
J Clin Invest. 2001
PubMed ID: 11696579
Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest.
Paramio JM, Segrelles C, Ruiz S, Jorcano JL
Mol Cell Biol. 2001
PubMed ID: 11585925
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice.
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ
J Biol Chem. 2001
PubMed ID: 11533044
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA
Science. 2001
PubMed ID: 11598301
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
Ravichandran LV, Chen H, Li Y, Quon MJ
Mol Endocrinol. 2001
PubMed ID: 11579209
Co-administration of finasteride and the pure anti-oestrogen ICI 182,780 act synergistically in modulating the IGF system in rat prostate.
Huynh H, Alpert L, Alaoui-Jamali MA, Ng CY, Chan TW
J Endocrinol. 2001
PubMed ID: 11572795
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.
Mayo LD, Donner DB
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11504915
MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.
Sodhi A, Montaner S, Miyazaki H, Gutkind JS
Biochem Biophys Res Commun. 2001
PubMed ID: 11549290
Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.
Sussman J, Stokoe D, Ossina N, Shtivelman E
J Cell Biol. 2001
PubMed ID: 11535620
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T
Mol Cell. 2001
PubMed ID: 11583630
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.
Chen WS, Xu PZ, Gottlob K, Chen ML, Sokol K, Shiyanova T, Roninson I, Weng W, Suzuki R, Tobe K, Kadowaki T, Hay N
Genes Dev. 2001
PubMed ID: 11544177
Regulation of Akt/PKB activation by tyrosine phosphorylation.
Chen R, Kim O, Yang J, Sato K, Eisenmann KM, McCarthy J, Chen H, Qiu Y
J Biol Chem. 2001
PubMed ID: 11445557
Complex formation and cooperation of protein kinase C theta and Akt1/protein kinase B alpha in the NF-kappa B transactivation cascade in Jurkat T cells.
Bauer B, Krumböck N, Fresser F, Hochholdinger F, Spitaler M, Simm A, Uberall F, Schraven B, Baier G
J Biol Chem. 2001
PubMed ID: 11410591
Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.
Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL
J Biol Chem. 2001
PubMed ID: 11410590
Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.
Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG
EMBO J. 2001
PubMed ID: 11500364
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343.
Persad S, Attwell S, Gray V, Mawji N, Deng JT, Leung D, Yan J, Sanghera J, Walsh MP, Dedhar S
J Biol Chem. 2001
PubMed ID: 11313365
Visualization of biochemical networks in living cells.
Remy I, Michnick SW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11438723
Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes.
Matsubara A, Wasson JC, Donelan SS, Welling CM, Glaser B, Permutt MA
Diabetologia. 2001
PubMed ID: 11508278
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor.
Lin HK, Yeh S, Kang HY, Chang C
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11404460
Mammary gland involution is delayed by activated Akt in transgenic mice.
Schwertfeger KL, Richert MM, Anderson SM
Mol Endocrinol. 2001
PubMed ID: 11376107
Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor.
Caloca MJ, Wang H, Delemos A, Wang S, Kazanietz MG
J Biol Chem. 2001
PubMed ID: 11278894
Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.
Brownawell AM, Kops GJ, Macara IG, Burgering BM
Mol Cell Biol. 2001
PubMed ID: 11313479
Inhibition of insulin-induced activation of Akt by a kinase-deficient mutant of the epsilon isozyme of protein kinase C.
Matsumoto M, Ogawa W, Hino Y, Furukawa K, Ono Y, Takahashi M, Ohba M, Kuroki T, Kasuga M
J Biol Chem. 2001
PubMed ID: 11278835
Akt mediates insulin induction of glucose uptake and up-regulation of GLUT4 gene expression in brown adipocytes.
Hernandez R, Teruel T, Lorenzo M
FEBS Lett. 2001
PubMed ID: 11311245
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.
Yamashita K, Kajstura J, Discher DJ, Wasserlauf BJ, Bishopric NH, Anversa P, Webster KA
Circ Res. 2001
PubMed ID: 11282895
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H
J Biol Chem. 2001
PubMed ID: 11139588
Akt phosphorylates and regulates the orphan nuclear receptor Nur77.
Pekarsky Y, Hallas C, Palamarchuk A, Koval A, Bullrich F, Hirata Y, Bichi R, Letofsky J, Croce CM
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11274386
Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta.
Guo S, Cichy SB, He X, Yang Q, Ragland M, Ghosh AK, Johnson PF, Unterman TG
J Biol Chem. 2001
PubMed ID: 11116148
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression.
Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ
Mol Cell Biol. 2001
PubMed ID: 11238953
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.
Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR
J Biol Chem. 2001
PubMed ID: 11042204
Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation.
Kapasi AA, Fan S, Singhal PC
Am J Physiol Renal Physiol. 2001
PubMed ID: 11208609
HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.
Zauli G, Milani D, Mirandola P, Mazzoni M, Secchiero P, Miscia S, Capitani S
FASEB J. 2001
PubMed ID: 11156964
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).
Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME
Mol Cell Biol. 2001
PubMed ID: 11154281
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1.
Kim AH, Khursigara G, Sun X, Franke TF, Chao MV
Mol Cell Biol. 2001
PubMed ID: 11154276
PDK2: a complex tail in one Akt.
Chan TO, Tsichlis PN
Sci STKE. 2001
PubMed ID: 11752635
PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.
Neudauer CL, Joberty G, Macara IG
Biochem Biophys Res Commun. 2001
PubMed ID: 11162552
HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway.
Wen Y, Hu MC, Makino K, Spohn B, Bartholomeusz G, Yan DH, Hung MC
Cancer Res. 2000
PubMed ID: 11156376
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.
Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Müller C, Grüning W, Kratz-Albers K, Serve S, Steur C, Büchner T, Kienast J, Kanakura Y, Berdel WE, Serve H
Blood. 2000
PubMed ID: 11090077
Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.
Koh H, Lee KH, Kim D, Kim S, Kim JW, Chung J
J Biol Chem. 2000
PubMed ID: 10926925
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.
Smith JL, Schaffner AE, Hofmeister JK, Hartman M, Wei G, Forsthoefel D, Hume DA, Ostrowski MC
Mol Cell Biol. 2000
PubMed ID: 11027273
Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A.
Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11035810
Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
Kirk RI, Sanderson MR, Lerea KM
J Biol Chem. 2000
PubMed ID: 10896934
Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.
Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F
Neuron. 2000
PubMed ID: 11086988
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Modulation of Akt kinase activity by binding to Hsp90.
Sato S, Fujita N, Tsuruo T
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10995457
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death.
Gabai VL, Yaglom JA, Volloch V, Meriin AB, Force T, Koutroumanis M, Massie B, Mosser DD, Sherman MY
Mol Cell Biol. 2000
PubMed ID: 10958679
Negative regulation of the serine/threonine kinase B-Raf by Akt.
Guan KL, Figueroa C, Brtva TR, Zhu T, Taylor J, Barber TD, Vojtek AB
J Biol Chem. 2000
PubMed ID: 10869359
PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain.
Ingley E, Hemmings BA
FEBS Lett. 2000
PubMed ID: 10930578
The protooncogene TCL1 is an Akt kinase coactivator.
Laine J, Künstle G, Obata T, Sha M, Noguchi M
Mol Cell. 2000
PubMed ID: 10983986
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival.
Meucci O, Fatatis A, Simen AA, Miller RJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10869418
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.
Sekulić A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM, Abraham RT
Cancer Res. 2000
PubMed ID: 10910062
Phosphorylation of the PTEN tail regulates protein stability and function.
Vazquez F, Ramaswamy S, Nakamura N, Sellers WR
Mol Cell Biol. 2000
PubMed ID: 10866658
Studies on the phosphorylation of protein kinase B by Ca(2+)/calmodulin-dependent protein kinases.
Okuno S, Kitani T, Matsuzaki H, Konishi H, Kikkawa U, Fujisawa H
J Biochem. 2000
PubMed ID: 10833263
A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells.
Madge LA, Pober JS
J Biol Chem. 2000
PubMed ID: 10748004
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo.
Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR, Ohashi PS
J Exp Med. 2000
PubMed ID: 10811865
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.
Holland EC, Celestino J, Dai C, Schaefer L, Sawaya RE, Fuller GN
Nat Genet. 2000
PubMed ID: 10802656
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10716693
The PI3K-PDK1 connection: more than just a road to PKB.
Vanhaesebroeck B, Alessi DR
Biochem J. 2000
PubMed ID: 10698680
Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.
Kwon T, Kwon DY, Chun J, Kim JH, Kang SS
J Biol Chem. 2000
PubMed ID: 10617634
Expression cloning of protein targets for 3-phosphorylated phosphoinositides.
Rao VR, Corradetti MN, Chen J, Peng J, Yuan J, Prestwich GD, Brugge JS
J Biol Chem. 1999
PubMed ID: 10608855
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.
Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, Choi Y
Mol Cell. 1999
PubMed ID: 10635328
The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
Sotsios Y, Whittaker GC, Westwick J, Ward SG
J Immunol. 1999
PubMed ID: 10570282
Phosphorylation and regulation of Raf by Akt (protein kinase B).
Zimmermann S, Moelling K
Science. 1999
PubMed ID: 10576742
Cellular survival: a play in three Akts.
Datta SR, Brunet A, Greenberg ME
Genes Dev. 1999
PubMed ID: 10579998
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H
J Biol Chem. 1999
PubMed ID: 10542266
Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.
Craxton A, Jiang A, Kurosaki T, Clark EA
J Biol Chem. 1999
PubMed ID: 10521450
The beta4 integrin subunit rescues A431 cells from apoptosis through a PI3K/Akt kinase signaling pathway.
Tang K, Nie D, Cai Y, Honn KV
Biochem Biophys Res Commun. 1999
PubMed ID: 10527852
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.
Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y
J Biol Chem. 1999
PubMed ID: 10497255
Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3.
Masure S, Haefner B, Wesselink JJ, Hoefnagel E, Mortier E, Verhasselt P, Tuytelaars A, Gordon R, Richardson A
Eur J Biochem. 1999
PubMed ID: 10491192
Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt.
Koh H, Jee K, Lee B, Kim J, Kim D, Yun YH, Kim JW, Choi HS, Chung J
Oncogene. 1999
PubMed ID: 10490848
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR
Oncogene. 1999
PubMed ID: 10490823
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling.
Romashkova JA, Makarov SS
Nature. 1999
PubMed ID: 10485711
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB
Nature. 1999
PubMed ID: 10485710
Akt is more than just a Bad kinase.
Khwaja A
Nature. 1999
PubMed ID: 10485701
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
Kitamura T, Kitamura Y, Kuroda S, Hino Y, Ando M, Kotani K, Konishi H, Matsuzaki H, Kikkawa U, Ogawa W, Kasuga M
Mol Cell Biol. 1999
PubMed ID: 10454575
The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase.
Gold MR, Scheid MP, Santos L, Dang-Lawson M, Roth RA, Matsuuchi L, Duronio V, Krebs DL
J Immunol. 1999
PubMed ID: 10438924
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oostuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E
Cell. 1999
PubMed ID: 10428027
Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1).
Takata M, Ogawa W, Kitamura T, Hino Y, Kuroda S, Kotani K, Klip A, Gingras AC, Sonenberg N, Kasuga M
J Biol Chem. 1999
PubMed ID: 10400692
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
Biggs WH, Meisenhelder J, Hunter T, Cavenee WK, Arden KC
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10377430
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
Rena G, Guo S, Cichy SC, Unterman TG, Cohen P
J Biol Chem. 1999
PubMed ID: 10358075
Negative regulation of the forkhead transcription factor FKHR by Akt.
Tang ED, Nuñez G, Barr FG, Guan KL
J Biol Chem. 1999
PubMed ID: 10358014
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation.
Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM
Nature. 1999
PubMed ID: 10376603
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt.
Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC
Nature. 1999
PubMed ID: 10376602
Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit.
Kang SS, Kwon T, Kwon DY, Do SI
J Biol Chem. 1999
PubMed ID: 10224060
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.
Balendran A, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Downes CP, Alessi DR
Curr Biol. 1999
PubMed ID: 10226025
Direct control of the Forkhead transcription factor AFX by protein kinase B.
Kops GJ, de Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM
Nature. 1999
PubMed ID: 10217147
Protein kinase Czeta is a negative regulator of protein kinase B activity.
Doornbos RP, Theelen M, van der Hoeven PC, van Blitterswijk WJ, Verkleij AJ, van Bergen en Henegouwen PM
J Biol Chem. 1999
PubMed ID: 10085094
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME
Cell. 1999
PubMed ID: 10102273
Identification of myosin II as a binding protein to the PH domain of protein kinase B.
Tanaka M, Konishi H, Touhara K, Sakane F, Hirata M, Ono Y, Kikkawa U
Biochem Biophys Res Commun. 1999
PubMed ID: 10082674
Growth arrest-specific gene 6 (Gas6)/adhesion related kinase (Ark) signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt.
Allen MP, Zeng C, Schneider K, Xiong X, Meintzer MK, Bellosta P, Basilico C, Varnum B, Heidenreich KA, Wierman ME
Mol Endocrinol. 1999
PubMed ID: 9973250
Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise.
Turinsky J, Damrau-Abney A
Am J Physiol. 1999
PubMed ID: 9887206
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation.
Chan TO, Rittenhouse SE, Tsichlis PN
Annu Rev Biochem. 1999
PubMed ID: 10872470
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
CREB is a regulatory target for the protein kinase Akt/PKB.
Du K, Montminy M
J Biol Chem. 1998
PubMed ID: 9829964
Regulation of cell death protease caspase-9 by phosphorylation.
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC
Science. 1998
PubMed ID: 9812896
Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.
Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A
Curr Biol. 1998
PubMed ID: 9768361
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.
Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9736715
Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport.
Kitamura T, Ogawa W, Sakaue H, Hino Y, Kuroda S, Takata M, Matsumoto M, Maeda T, Konishi H, Kikkawa U, Kasuga M
Mol Cell Biol. 1998
PubMed ID: 9632753
The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136.
Blume-Jensen P, Janknecht R, Hunter T
Curr Biol. 1998
PubMed ID: 9651683
Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.
Altomare DA, Lyons GE, Mitsuuchi Y, Cheng JQ, Testa JR
Oncogene. 1998
PubMed ID: 9620559
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
Walker KS, Deak M, Paterson A, Hudson K, Cohen P, Alessi DR
Biochem J. 1998
PubMed ID: 9512493
Insulin increases the association of Akt-2 with Glut4-containing vesicles.
Calera MR, Martinez C, Liu H, Jack AK, Birnbaum MJ, Pilch PF
J Biol Chem. 1998
PubMed ID: 9516411
Role of translocation in the activation and function of protein kinase B.
Andjelković M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA
J Biol Chem. 1997
PubMed ID: 9395488
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.
Cong LN, Chen H, Li Y, Zhou L, McGibbon MA, Taylor SI, Quon MJ
Mol Endocrinol. 1997
PubMed ID: 9415393
Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.
Borgatti P, Zauli G, Colamussi ML, Gibellini D, Previati M, Cantley LL, Capitani S
Eur J Immunol. 1997
PubMed ID: 9394803
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
Shaw M, Cohen P, Alessi DR
FEBS Lett. 1997
PubMed ID: 9373175
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
del Peso L, González-García M, Page C, Herrera R, Nuñez G
Science. 1997
PubMed ID: 9381178
3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.
Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M
Curr Biol. 1997
PubMed ID: 9368760
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.
D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L
EMBO J. 1997
PubMed ID: 9312003
Akt signaling: linking membrane events to life and death decisions.
Hemmings BA
Science. 1997
PubMed ID: 9019819
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate.
Franke TF, Kaplan DR, Cantley LC, Toker A
Science. 1997
PubMed ID: 9005852
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation.
Kohn AD, Summers SA, Birnbaum MJ, Roth RA
J Biol Chem. 1996
PubMed ID: 8940145
Mechanism of activation of protein kinase B by insulin and IGF-1.
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA
EMBO J. 1996
PubMed ID: 8978681
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA
Nature. 1995
PubMed ID: 8524413
Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins.
Konishi H, Kuroda S, Tanaka M, Matsuzaki H, Ono Y, Kameyama K, Haga T, Kikkawa U
Biochem Biophys Res Commun. 1995
PubMed ID: 7488143
Rejection antigen peptides on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes: derivation from the normally untranslated 5' region of the c-akt proto-oncogene activated by long terminal repeat.
Wada H, Matsuo M, Uenaka A, Shimbara N, Shimizu K, Nakayama E
Cancer Res. 1995
PubMed ID: 7585504
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN
Cell. 1995
PubMed ID: 7774014
AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation.
Datta K, Franke TF, Chan TO, Makris A, Yang SI, Kaplan DR, Morrison DK, Golemis EA, Tsichlis PN
Mol Cell Biol. 1995
PubMed ID: 7891724
Molecular cloning of rat RAC protein kinase alpha and beta and their association with protein kinase C zeta.
Konishi H, Shinomura T, Kuroda S, Ono Y, Kikkawa U
Biochem Biophys Res Commun. 1994
PubMed ID: 7999118
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguchi T, Gardner J, Cheng JQ, Testa JR, Tsichlis PN
Oncogene. 1993
PubMed ID: 8437858
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.
Coffer PJ, Woodgett JR
Eur J Biochem. 1992
PubMed ID: 1533586
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families.
Coffer PJ, Woodgett JR
Eur J Biochem. 1991
PubMed ID: 1718748
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily.
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1851997
A linkage map of distal mouse chromosome 12.
Cho M, Villani V, D'Eustachio P
Mamm Genome. 1991
PubMed ID: 1794043
The AKT1 proto-oncogene maps to human chromosome 14, band q32.
Staal SP, Huebner K, Croce CM, Parsa NZ, Testa JR
Genomics. 1988
PubMed ID: 3384441
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.
Staal SP
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3037531

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	207	11651	24185
EnsEMBL Gene(s)	ENSG00000142208	ENSMUSG00000001729	ENSRNOG00000028629
Unigene	Hs.525622	Mm.6645	Rn.11422
Homologene	AKT1	Akt1	Akt1
OMIM	164730	N/A	N/A
GeneCards	AKT1	N/A	N/A
Beta Cell Genomics	DT.100059719 DT.100059721 DT.100059722 DT.100733482 DT.100824191 DT.120765973 DT.450038 DT.92461206 DT.95090241 DT.95341680	DT.101403566 DT.535357 DT.94188038 DT.94396697	N/A
Reactome	P31749	P31750	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	207	11651	24185

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
AKT1	BCL2L11	HPRD, IntAct, BioGRID	empirical	16282323
AKT1	TRIM13	BioGRID	empirical	21333377
AKT1	CDKN1A	HPRD	empirical	11756412
AKT1	CDKN1B	HPRD, MINT, BioGRID	empirical	12244301 12042314
AKT1	STUB1	BioGRID	empirical	18292230 21767636
AKT1	TUBB4B	IntAct	empirical	20856200
AKT1	DLC1	HPRD	empirical	16338927
AKT1	YAP1	HPRD	empirical	12535517
AKT1	SH2B2	HPRD	empirical	16141217
AKT1	TOPBP1	HPRD, MINT	empirical	17006541
AKT1	CHEK1	HPRD	empirical	12062056
AKT1	CDC37	IntAct, BioGRID	empirical	12176997
AKT1	CHN2	BioGRID	empirical	11278894
AKT1	ZHX1	BioGRID	empirical	21900206
AKT1	PHB2	HPRD	empirical	15173318
AKT1	CHUK	HPRD, BioGRID	empirical	10485710 10485711 15800029
AKT1	THEM4	HPRD, BioGRID, Reactome	empirical	11598301 12791994
AKT1	RHEBL1	HPRD	empirical	16098514
AKT1	MAP3K8	HPRD, BioGRID	empirical	12138205
AKT1	PPARGC1B	HPRD	empirical	17554339
AKT1	CREB1	HPRD	empirical	9829964
AKT1	CREBBP	BioGRID	empirical	19995607
AKT1	MAPK14	BioGRID	empirical	11042204
AKT1	CTBP1	BioGRID	empirical	20361981
AKT1	COMMD1	IntAct, BioGRID	empirical	18624398 20237237
AKT1	PEBP4	MINT	empirical	19197339
AKT1	DCTN1	BioGRID	empirical	21900206
AKT1	DDX5	IntAct	empirical	20856200
AKT1	ASXL1	IntAct, BioGRID	empirical	18624398
AKT1	DNMT1	BioGRID	empirical	21151116
AKT1	S1PR1	HPRD	empirical	11583630
AKT1	EEF1G	BioGRID	empirical	21900206
AKT1	AHSG	IntAct	empirical	18624398
AKT1	EIF4EBP1	HPRD	empirical	11777913
AKT1	MARK2	BioGRID	empirical	18292230
AKT1	EP300	HPRD, IntAct, BioGRID	empirical	11116148 21775285 18182168
AKT1	ERBB3	BioGRID	empirical	21930127
AKT1	AKT1	HPRD, IntAct	empirical	7891724 9395488
AKT1	AKT2	HPRD, BioGRID	empirical	12176337 12149249 11445557 11546794 14500673 9736715 11278835 15545269
AKT1	ESR1	HPRD, BioGRID	empirical	11139588
AKT1	ESR2	HPRD	empirical	15001646
AKT1	EZH2	HPRD	empirical	16224021
AKT1	FANCA	HPRD	empirical	11855836
AKT1	MS4A2	HPRD	empirical	19356729
AKT1	FKBP5	BioGRID	empirical	20605778
AKT1	FOXO1	HPRD, BioGRID	empirical	10358014 16076959
AKT1	FOXO3	HPRD	empirical	10102273
AKT1	PHLPP1	BioGRID	empirical	20605778
AKT1	SIRT1	IntAct	empirical	21775285
AKT1	CARHSP1	BioGRID	empirical	15910284
AKT1	ARFIP2	BioGRID	empirical	9312003
AKT1	MTOR	HPRD, MINT, BioGRID	empirical	11438723 10910062 15718470 14970221 21045808
AKT1	RICTOR	IntAct, BioGRID	empirical	21339740 15718470
AKT1	APPL1	HPRD	empirical	12621049
AKT1	GATA1	HPRD	empirical	16107690
AKT1	GATA2	HPRD	empirical	15837948
AKT1	GRB10	HPRD	empirical	11809791
AKT1	GSK3A	HPRD, BioGRID	empirical	11035810 11884598 8524413 19995607
AKT1	GSK3B	HPRD, IntAct, BioGRID	empirical	11035810 8524413 20856200 16282323 16009706 19995607
AKT1	TRHDE	IntAct	empirical	20856200
AKT1	HTT	HPRD	empirical	12062094
AKT1	HMOX1	HPRD, MINT	empirical	15581622
AKT1	NR4A1	HPRD, BioGRID	empirical	11274386
AKT1	HSPA4	BioGRID	empirical	12750378
AKT1	XIAP	HPRD, BioGRID	empirical	14645242
AKT1	HSPA9	IntAct	empirical	20856200
AKT1	HSPB1	BioGRID	empirical	11042204
AKT1	HSP90AA1	HPRD, MINT, BioGRID, Reactome	empirical	10995457 19356729 18566586 12586360 15843522 12176997 21767636 11879202 15476407 10376602 10469573 10376603
AKT1	HSP90AB1	HPRD, BioGRID	empirical	10995457
AKT1	DNAJB1	IntAct, BioGRID	empirical	18624398
AKT1	APLP2	HPRD	empirical	10490823
AKT1	APOH	IntAct, BioGRID	empirical	18624398
AKT1	IKBKB	HPRD, BioGRID	empirical	10485711 15856005
AKT1	ILK	HPRD, BioGRID	empirical	9736715 12176337 12149249 11445557 11546794 14500673 11278835 11825911 11313365
AKT1	IMPDH2	HPRD, BioGRID	empirical	10930578
AKT1	IRAK1	HPRD, BioGRID	empirical	11976320
AKT1	IRS1	HPRD, BioGRID	empirical	10497255
AKT1	AR	HPRD	empirical	11404460 11156376 16210317
AKT1	ITGB3	HPRD	empirical	10896934
AKT1	KRT10	HPRD, BioGRID	empirical	11585925
AKT1	KTN1	BioGRID	empirical	11162552
AKT1	ARRB1	IntAct	empirical	16051150
AKT1	MXD1	BioGRID	empirical	19526459 18451027
AKT1	SMAD2	HPRD, MINT, BioGRID	empirical	16362038
AKT1	SMAD3	HPRD, MINT, BioGRID	empirical	16362038
AKT1	SMAD4	HPRD, MINT, BioGRID	empirical	16362038
AKT1	ARRB2	IntAct, BioGRID	empirical	18191226 16051150
AKT1	SMAD7	HPRD, MINT, BioGRID	empirical	16362038
AKT1	MAPT	MINT	empirical	17512525
AKT1	MDM2	HPRD, MINT, IntAct, BioGRID	empirical	12145204 11504915 15527798 19166854 20856200 11923280 11715018 21930127
AKT1	MDM4	HPRD	empirical	16163388
AKT1	MAP3K5	HPRD, IntAct	empirical	11154276
AKT1	METTL1	HPRD	empirical	15861136
AKT1	MAP3K11	HPRD, BioGRID	empirical	12458207
AKT1	FOXO4	HPRD	empirical	11313479 10217147 11689711 16272144
AKT1	MST1R	HPRD	empirical	12919677
AKT1	MTCP1	HPRD, BioGRID	empirical	11707444 10983986
AKT1	NEDD4	BioGRID	empirical	19953087
AKT1	NF2	BioGRID	empirical	17891137
AKT1	NFKB1	MINT	empirical	16642037
AKT1	NOS3	HPRD	empirical	11696579 10376603
AKT1	NOTCH1	BioGRID	empirical	18440314
AKT1	NPM1	BioGRID	empirical	18931307
AKT1	YBX1	HPRD	empirical	16354698
AKT1	PA2G4	BioGRID	empirical	21930127
AKT1	PAK1	HPRD, BioGRID	empirical	12138087 14749719
AKT1	PDE3A	MINT	empirical	17124499
AKT1	PDE3B	HPRD	empirical	10454575
AKT1	PDK2	HPRD	empirical	10438924
AKT1	PDPK1	HPRD, MINT, IntAct, Reactome	empirical	11825911 11438723 10698680 12149249 11445557 14500673 11278835 9368760 10226025 21775285 7637810 9736715 15718470
AKT1	PFKFB2	HPRD	empirical	12853467
AKT1	PIK3R1	HPRD	empirical	10527852
AKT1	PLCG1	MINT	empirical	16525023
AKT1	PLXNA1	HPRD	empirical	15187088
AKT1	PLXNB1	BioGRID	empirical	19805522
AKT1	PPA1	BioGRID	empirical	16186112
AKT1	PPL	HPRD, MINT, IntAct, BioGRID	empirical	12176997 18624398 12244133 15102471
AKT1	PPM1A	HPRD	empirical	15016818
AKT1	PPP2CA	HPRD, MINT, BioGRID	empirical	11438723 12637511 16044149 18191226
AKT1	PPP2R1A	MINT	empirical	16044149
AKT1	PI4K2B	IntAct, BioGRID	empirical	18624398
AKT1	PRG2	HPRD	empirical	10698680 12149249 11445557 14500673 11278835 12176337 11546794 9736715
AKT1	CCDC88A	HPRD	empirical	16139227
AKT1	PRKCE	IntAct	empirical	11139474
AKT1	PKN2	HPRD, MINT	empirical	10926925 17446865
AKT1	PRKCQ	HPRD, BioGRID	empirical	11410591
AKT1	PRKCZ	HPRD, MINT, BioGRID	empirical	10085094 11723139 14560023 18650932
AKT1	PRKDC	HPRD	empirical	15262962
AKT1	SERTAD4	IntAct	empirical	20368287
AKT1	PAK6	BioGRID	empirical	11773441
AKT1	BAD	HPRD, BioGRID	empirical	9381178 11500364
AKT1	PTEN	HPRD	empirical	12077256 10866658 12297295
AKT1	PREX1	IntAct	empirical	21339740
AKT1	SH3RF1	IntAct	empirical	17535800
AKT1	PTPN1	HPRD, MINT	empirical	11579209
AKT1	TRIB3	HPRD, IntAct, BioGRID, Reactome	empirical	12791994 11598301
AKT1	ACTA1	BioGRID	empirical	16568092
AKT1	RAC1	HPRD	empirical	10617634
AKT1	RAF1	HPRD, MINT, BioGRID	empirical	10576742 19058874 19197339
AKT1	ACTB	IntAct	empirical	20856200
AKT1	RPS6KB1	HPRD, MINT, BioGRID	empirical	11438723 15149849
AKT1	ATXN1	HPRD	empirical	12757707 12741986
AKT1	MAP2K4	HPRD, BioGRID	empirical	11707464
AKT1	AKTIP	HPRD, BioGRID	empirical	14749367
AKT1	SKP2	BioGRID	empirical	19270694 21358672
AKT1	WNK1	HPRD	empirical	14611643
AKT1	NCF1	HPRD	empirical	12734380
AKT1	SMARCB1	BioGRID	empirical	16568092
AKT1	SMARCC1	BioGRID	empirical	16568092
AKT1	SMARCC2	BioGRID	empirical	16568092
AKT1	BPGM	IntAct, BioGRID	empirical	18624398
AKT1	SRC	HPRD	empirical	11445557
AKT1	BRCA1	HPRD, IntAct, BioGRID	empirical	10542266 21242970 19074868
AKT1	BRAF	HPRD, BioGRID	empirical	10869359 11410590
AKT1	ZFP36L1	MINT	empirical	15538381
AKT1	STAT1	HPRD	empirical	15284024
AKT1	STK4	MINT	empirical	17932490
AKT1	TERT	MINT, BioGRID	empirical	18775701 15843522
AKT1	TPM2	IntAct	empirical	20856200
AKT1	TPM4	IntAct	empirical	20856200
AKT1	TSC1	HPRD, BioGRID	empirical	12167664 15342917
AKT1	TSC2	HPRD, BioGRID	empirical	12438239 12150915 12167664 15342917
AKT1	TTC3	BioGRID	empirical	20059950
AKT1	UBC	BioGRID	empirical	18292230 12750378 11923280 21333377 20059950 21464312 21045808 21262463 20336670 21139048 21890473 21906983
AKT1	VEGFA	HPRD	empirical	17318185
AKT1	VIM	IntAct	empirical	20856200
AKT1	YWHAZ	HPRD, BioGRID	empirical	11956222
AKT1	AHNAK	HPRD	empirical	11535620
AKT1	MAPKAP1	MINT, BioGRID	empirical	18566586 16962653
AKT1	UXS1	HPRD, BioGRID	empirical	11877387
AKT1	NCOA4	IntAct, BioGRID	empirical	18624398
AKT1	TCL1A	HPRD, BioGRID	empirical	10983986 12009899 11707444
AKT1	HIST2H2BE	HPRD	empirical	9973250
AKT1	CASP3	HPRD, MINT	empirical	12124386 17544405
AKT1	CASP9	HPRD	empirical	9812896
AKT1	CAMKK1	HPRD	empirical	10833263
AKT1	AKT1S1	HPRD	empirical	12524439 14973226
AKT1	SORBS2	HPRD, MINT	empirical	15784622
AKT1	IKBKG	BioGRID	empirical	20098747 20837477
AKT1	PIAS1	BioGRID	empirical	17533377
AKT1	TNFSF11	HPRD	empirical	10635328
AKT1	PEA15	HPRD	empirical	12808093
AKT1	HDAC3	BioGRID	empirical	20026773
AKT1	KAT2B	IntAct	empirical	21775285
AKT1	BCL10	HPRD, IntAct	empirical	16280327
AKT1	USP8	BioGRID	empirical	17210635
AKT1	MAPKAPK2	HPRD, BioGRID	empirical	11042204
AKT1	RPL23	IntAct	empirical	20368287
AKT1	ARHGAP29	BioGRID	empirical	14749388
AKT1	MAPK8IP1	HPRD, MINT, BioGRID	empirical	12194869 16343492
AKT1	RAB3D	HPRD	empirical	11903042
AKT1	TCL1B	HPRD, BioGRID	empirical	10983986
AKT1	ARHGAP32	BioGRID	empirical	12446789
AKT1	GAB2	HPRD, BioGRID	empirical	11782427
AKT1	SETDB1	IntAct, BioGRID	empirical	17577629