EPB41

Summary Top Help

Gene Description:

erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked); erythrocyte membrane protein band 4.1; erythrocyte protein band 4.1

Synonyms:

EPB41, Epb41, Epb4.1, HE, D4Ertd442e, EL1, 4.1R, mKIAA4056, AI415518, RGD1564762, Elp1, Elp-1

Orthologs:

Human EPB41 (protein-coding), Mouse Epb4.1 (protein-coding), Rat Epb4.1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd11	Mouse	chr4:125017654..132983386	7.97	148	4 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr1:29213603..29446558 (232.96 kb) View in Genome Browser

(Mouse) NCBIM37 - chr4:131479328..131631236 (151.91 kb) View in Genome Browser

(Rat) RGSC3.4 - chr5:150782245..150908889 (126.64 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for EPB41:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for EPB41:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 21

Publications from PubMed Top Help

Publications: 155

RBFOX2 promotes protein 4.1R exon 16 selection via U1 snRNP recruitment.
Huang SC, Ou AC, Park J, Yu F, Yu B, Lee A, Yang G, Zhou A, Benz EJ
Mol Cell Biol. 2012
PubMed ID: 22083953
Structural stabilization of protein 4.1R FERM domain upon binding to apo-calmodulin: novel insights into the biological significance of the calcium-independent binding of calmodulin to protein 4.1R.
Nunomura W, Sasakura D, Shiba K, Nakamura S, Kidokoro S, Takakuwa Y
Biochem J. 2011
PubMed ID: 21848512
Protein 4.1R regulates cell migration and IQGAP1 recruitment to the leading edge.
Ruiz-Sáenz A, Kremer L, Alonso MA, Millán J, Correas I
J Cell Sci. 2011
PubMed ID: 21750196
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility.
Yang S, Weng H, Chen L, Guo X, Parra M, Conboy J, Debnath G, Lambert AJ, Peters LL, Baines AJ, Mohandas N, An X
Mol Cell Biol. 2011
PubMed ID: 21482674
Structural protein 4.1R is integrally involved in nuclear envelope protein localization, centrosome-nucleus association and transcriptional signaling.
Meyer AJ, Almendrala DK, Go MM, Krauss SW
J Cell Sci. 2011
PubMed ID: 21486941
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.
Jung Y, Kissil JL, McCarty JH
Dev Dyn. 2011
PubMed ID: 21181944
Nonsense-mediated mRNA decay (NMD) blockage promotes nonsense mRNA stabilization in protein 4.1R deficient cells carrying the 4.1R Coimbra variant of hereditary elliptocytosis.
Morinière M, Delhommeau F, Calender A, Ribeiro L, Delaunay J, Baklouti F
Blood Cells Mol Dis. 2010
PubMed ID: 20863723
Identification of SNP markers on 1p36 and association analysis of EPB41 with mandibular prognathism in a Chinese population.
Xue F, Wong R, Rabie AB
Arch Oral Biol. 2010
PubMed ID: 20797695
The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.
Korsgren C, Lux SE
Blood. 2010
PubMed ID: 20585040
Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.
Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20696915
Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation.
Salomao M, Chen K, Villalobos J, Mohandas N, An X, Chasis JA
Blood. 2010
PubMed ID: 20339087
The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.
Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE
Dev Biol. 2010
PubMed ID: 20347762
Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner.
Korsgren C, Peters LL, Lux SE
J Biol Chem. 2010
PubMed ID: 20007969
Protein 4.1 expression in the developing hair cells of the mouse inner ear.
Okumura K, Mochizuki E, Yokohama M, Yamakawa H, Shitara H, Mburu P, Yonekawa H, Brown SD, Kikkawa Y
Brain Res. 2010
PubMed ID: 19853587
Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene.
Huang SC, Cho A, Norton S, Liu ES, Park J, Zhou A, Munagala ID, Ou AC, Yang G, Wickrema A, Tang TK, Benz EJ
Blood. 2009
PubMed ID: 19729518
4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins.
Jeremy KP, Plummer ZE, Head DJ, Madgett TE, Sanders KL, Wallington A, Storry JR, Gilsanz F, Delaunay J, Avent ND
Haematologica. 2009
PubMed ID: 19794081
[Expression and significance of membrane skeleton protein 4.1 family in non-small cell lung cancer].
Zheng XY, Qi YM, Gao YF, Wang XY, Qi MX, Shi XF, An XL
Ai Zheng. 2009
PubMed ID: 19624891
Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity.
Yang S, Guo X, Debnath G, Mohandas N, An X
Biochim Biophys Acta. 2009
PubMed ID: 19376086
Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain.
Kusunoki H, Kohno T
Proteins. 2009
PubMed ID: 19338061
Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT.
Kang Q, Yu Y, Pei X, Hughes R, Heck S, Zhang X, Guo X, Halverson G, Mohandas N, An X
Blood. 2009
PubMed ID: 19190245
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Protein 4.1 and the control of ion channels.
Baines AJ, Bennett PM, Carter EW, Terracciano C
Blood Cells Mol Dis. 2009
PubMed ID: 19272819
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin.
Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L
Cell. 2009
PubMed ID: 19185337
Alternatively spliced exon 5 of the FERM domain of protein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells.
Seo PS, Jeong JJ, Zeng L, Takoudis CG, Quinn BJ, Khan AA, Hanada T, Chishti AH
Biochim Biophys Acta. 2009
PubMed ID: 18952129
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
Marked difference in membrane-protein-binding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation.
Nunomura W, Parra M, Hebiguchi M, Sawada K, Mohandas N, Takakuwa Y
Biochem J. 2009
PubMed ID: 18691159
alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.
Legendre K, Safieddine S, Küssel-Andermann P, Petit C, El-Amraoui A
J Cell Sci. 2008
PubMed ID: 18796539
Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart.
Stagg MA, Carter E, Sohrabi N, Siedlecka U, Soppa GK, Mead F, Mohandas N, Taylor-Harris P, Baines A, Bennett P, Yacoub MH, Pinder JC, Terracciano CM
Circ Res. 2008
PubMed ID: 18787192
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Targeted deletion of {alpha}-adducin results in absent {beta}- and {gamma}-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
Robledo RF, Ciciotte SL, Gwynn B, Sahr KE, Gilligan DM, Mohandas N, Peters LL
Blood. 2008
PubMed ID: 18723693
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane.
Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18524950
Downregulation of protein 4.1R, a mature centriole protein, disrupts centrosomes, alters cell cycle progression, and perturbs mitotic spindles and anaphase.
Krauss SW, Spence JR, Bahmanyar S, Barth AI, Go MM, Czerwinski D, Meyer AJ
Mol Cell Biol. 2008
PubMed ID: 18212055
Association between myeloid malignancies and acquired deficit in protein 4.1R: a retrospective analysis of six patients.
Alanio-Bréchot C, Schischmanoff PO, Fénéant-Thibault M, Cynober T, Tchernia G, Delaunay J, Garçon L
Am J Hematol. 2008
PubMed ID: 17994571
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Intrasplicing coordinates alternative first exons with alternative splicing in the protein 4.1R gene.
Parra MK, Tan JS, Mohandas N, Conboy JG
EMBO J. 2008
PubMed ID: 18079699
Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.
Yang G, Huang SC, Wu JY, Benz EJ
Blood. 2008
PubMed ID: 17715393
Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.
Shao H, Reed DR, Tordoff MG
Mamm Genome. 2007
PubMed ID: 18008102
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Neuroacanthocytosis associated with a defect of the 4.1R membrane protein.
Orlacchio A, Calabresi P, Rum A, Tarzia A, Salvati AM, Kawarai T, Stefani A, Pisani A, Bernardi G, Cianciulli P, Caprari P
BMC Neurol. 2007
PubMed ID: 17298666
Protein 4.1R self-association: identification of the binding domain.
Pérez-Ferreiro CM, Lospitao E, Correas I
Biochem J. 2006
PubMed ID: 16881872
Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes.
Rivera A, De Franceschi L, Peters LL, Gascard P, Mohandas N, Brugnara C
Am J Physiol Cell Physiol. 2006
PubMed ID: 16774987
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins.
An X, Zhang X, Debnath G, Baines AJ, Mohandas N
Biochemistry. 2006
PubMed ID: 16669616
Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16.
Ponthier JL, Schluepen C, Chen W, Lersch RA, Gee SL, Hou VC, Lo AJ, Short SA, Chasis JA, Winkelmann JC, Conboy JG
J Biol Chem. 2006
PubMed ID: 16537540
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Quantitative trait loci for baseline erythroid traits.
Peters LL, Lambert AJ, Zhang W, Churchill GA, Brugnara C, Platt OS
Mamm Genome. 2006
PubMed ID: 16596451
The 10 kDa domain of human erythrocyte protein 4.1 binds the Plasmodium falciparum EBA-181 protein.
Lanzillotti R, Coetzer TL
Malar J. 2006
PubMed ID: 17087826
New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.
Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P
Front Biosci. 2006
PubMed ID: 16368544
Regulation of protein 4.1R interactions with membrane proteins by Ca2+ and calmodulin.
Nunomura W, Takakuwa Y
Front Biosci. 2006
PubMed ID: 16368534
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.
Cioffi DL, Wu S, Alexeyev M, Goodman SR, Zhu MX, Stevens T
Circ Res. 2005
PubMed ID: 16254212
GADD45A and EPB41 as tumor suppressor genes in meningioma pathogenesis.
Piaskowski S, Rieske P, Szybka M, Wozniak K, Bednarek A, Płuciennik E, Jaskolski D, Sikorska B, Liberski PP
Cancer Genet Cytogenet. 2005
PubMed ID: 16157202
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis.
De Franceschi L, Rivera A, Fleming MD, Honczarenko M, Peters LL, Gascard P, Mohandas N, Brugnara C
Blood. 2005
PubMed ID: 15855279
Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate.
An X, Debnath G, Guo X, Liu S, Lux SE, Baines A, Gratzer W, Mohandas N
Biochemistry. 2005
PubMed ID: 16060676
Alterations of protein 4.1 family members in ependymomas: a study of 84 cases.
Rajaram V, Gutmann DH, Prasad SK, Mansur DB, Perry A
Mod Pathol. 2005
PubMed ID: 15731777
Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.
Manno S, Takakuwa Y, Mohandas N
J Biol Chem. 2005
PubMed ID: 15611095
Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location--relevance to membrane integrity, microstructure, and possible role in heart failure.
Taylor-Harris PM, Keating LA, Maggs AM, Phillips GW, Birks EJ, Franklin RC, Yacoub MH, Baines AJ, Pinder JC
Mamm Genome. 2005
PubMed ID: 15834631
Protein 4.1R expression in normal and dystrophic skeletal muscle.
Delhommeau F, Dalla Venezia N, Morinière M, Collin H, Maillet P, Guerfali I, Leclerc P, Fardeau M, Delaunay J, Baklouti F
C R Biol. 2005
PubMed ID: 15714879
Mitotic regulation of protein 4.1R involves phosphorylation by cdc2 kinase.
Huang SC, Liu ES, Chan SH, Munagala ID, Cho HT, Jagadeeswaran R, Benz EJ
Mol Biol Cell. 2005
PubMed ID: 15525677
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Protein 4.1R regulates interphase microtubule organization at the centrosome.
Pérez-Ferreiro CM, Vernos I, Correas I
J Cell Sci. 2004
PubMed ID: 15564380
Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.
Grimsby S, Jaensson H, Dubrovska A, Lomnytska M, Hellman U, Souchelnytskyi S
FEBS Lett. 2004
PubMed ID: 15527767
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Protein 4.1R, a microtubule-associated protein involved in microtubule aster assembly in mammalian mitotic extract.
Huang SC, Jagadeeswaran R, Liu ES, Benz EJ
J Biol Chem. 2004
PubMed ID: 15184364
Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin.
Kroviarski Y, El Nemer W, Gane P, Rahuel C, Gauthier E, Lecomte MC, Cartron JP, Colin Y, Le Van Kim C
Br J Haematol. 2004
PubMed ID: 15238148
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Ubiquitination of spectrin regulates the erythrocyte spectrin-protein-4.1-actin ternary complex dissociation: implications for the sickle cell membrane skeleton.
Ghatpande SS, Goodman SR
Cell Mol Biol (Noisy-le-grand). 2004
PubMed ID: 15040429
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Nuclear actin and protein 4.1: essential interactions during nuclear assembly in vitro.
Krauss SW, Chen C, Penman S, Heald R
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12960380
Protein 4.1-mediated membrane targeting of human discs large in epithelial cells.
Hanada T, Takeuchi A, Sondarva G, Chishti AH
J Biol Chem. 2003
PubMed ID: 12807908
Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis.
Robb VA, Li W, Gascard P, Perry A, Mohandas N, Gutmann DH
Neurobiol Dis. 2003
PubMed ID: 12901833
Alternative 5' exons and differential splicing regulate expression of protein 4.1R isoforms with distinct N-termini.
Parra MK, Gee SL, Koury MJ, Mohandas N, Conboy JG
Blood. 2003
PubMed ID: 12522012
An alternative domain containing a leucine-rich sequence regulates nuclear cytoplasmic localization of protein 4.1R.
Luque CM, Pérez-Ferreiro CM, Pérez-Gonzalez A, Englmeier L, Koffa MD, Correas I
J Biol Chem. 2003
PubMed ID: 12427749
Molecular cloning and characterization of the protein 4.1O gene, a novel member of the protein 4.1 family with focal expression in ovary.
Ni X, Ji C, Cao G, Cheng H, Guo L, Gu S, Ying K, Zhao RC, Mao Y
J Hum Genet. 2003
PubMed ID: 12601556
Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres.
Denisenko-Nehrbass N, Oguievetskaia K, Goutebroze L, Galvez T, Yamakawa H, Ohara O, Carnaud M, Girault JA
Eur J Neurosci. 2003
PubMed ID: 12542678
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch.
Hou VC, Lersch R, Gee SL, Ponthier JL, Lo AJ, Wu M, Turck CW, Koury M, Krainer AR, Mayeda A, Conboy JG
EMBO J. 2002
PubMed ID: 12426391
A splicing alteration of 4.1R pre-mRNA generates 2 protein isoforms with distinct assembly to spindle poles in mitotic cells.
Delhommeau F, Vasseur-Godbillon C, Leclerc P, Schischmanoff PO, Croisille L, Rince P, Morinière M, Benz EJ, Tchernia G, Tamagnini G, Ribeiro L, Delaunay J, Baklouti F
Blood. 2002
PubMed ID: 12239178
D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N.
Binda AV, Kabbani N, Lin R, Levenson R
Mol Pharmacol. 2002
PubMed ID: 12181426
Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development.
Hanspal M, Dua M, Takakuwa Y, Chishti AH, Mizuno A
Blood. 2002
PubMed ID: 12130521
Mapping of a spectrin-binding domain of human erythrocyte membrane protein 4.2.
Mandal D, Moitra PK, Basu J
Biochem J. 2002
PubMed ID: 12049649
Functional characterization of spectrin-actin-binding domains in 4.1 family of proteins.
Gimm JA, An X, Nunomura W, Mohandas N
Biochemistry. 2002
PubMed ID: 12044158
Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas.
Huang S, Lichtenauer UD, Pack S, Wang C, Kim AC, Lutchman M, Koch CA, Torres-Cruz J, Huang SC, Benz EJ, Christiansen H, Dockhorn-Dworniczak B, Poremba C, Vortmeyer AO, Chishti AH, Zhuang Z
Eur J Clin Invest. 2001
PubMed ID: 11737230
Structural and functional characterization of protein 4.1R-phosphatidylserine interaction: potential role in 4.1R sorting within cells.
An XL, Takakuwa Y, Manno S, Han BG, Gascard P, Mohandas N
J Biol Chem. 2001
PubMed ID: 11423550
Properties of the C-terminal domain of 4.1 proteins.
Scott C, Phillips GW, Baines AJ
Eur J Biochem. 2001
PubMed ID: 11432737
The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation.
Kontrogianni-Konstantopoulos A, Frye CS, Benz EJ, Huang SC
J Biol Chem. 2001
PubMed ID: 11274145
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers.
Kontrogianni-Konstantopoulos A, Huang SC, Benz EJ
Mol Biol Cell. 2000
PubMed ID: 11071908
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization.
Han BG, Nunomura W, Takakuwa Y, Mohandas N, Jap BK
Nat Struct Biol. 2000
PubMed ID: 11017195
Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex.
Hung LY, Tang CJ, Tang TK
Mol Cell Biol. 2000
PubMed ID: 11003675
Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton.
Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ
J Biol Chem. 2000
PubMed ID: 10874042
Protein 4.1R binding to eIF3-p44 suggests an interaction between the cytoskeletal network and the translation apparatus.
Hou CL, Tang C, Roffler SR, Tang TK
Blood. 2000
PubMed ID: 10887144
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Ca(2+)-dependent and Ca(2+)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins.
Nunomura W, Takakuwa Y, Parra M, Conboy JG, Mohandas N
J Biol Chem. 2000
PubMed ID: 10692436
Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R.
Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG
Mol Biol Cell. 1999
PubMed ID: 10359596
A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein.
Mattagajasingh SN, Huang SC, Hartenstein JS, Snyder M, Marchesi VT, Benz EJ
J Cell Biol. 1999
PubMed ID: 10189366
Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities.
Shi ZT, Afzal V, Coller B, Patel D, Chasis JA, Parra M, Lee G, Paszty C, Stevens M, Walensky L, Peters LL, Mohandas N, Rubin E, Conboy JG
J Clin Invest. 1999
PubMed ID: 9927493
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.
Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG
Genomics. 1998
PubMed ID: 9828140
Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1.
Walensky LD, Shi ZT, Blackshaw S, DeVries AC, Demas GE, Gascard P, Nelson RJ, Conboy JG, Rubin EM, Snyder SH, Mohandas N
Curr Biol. 1998
PubMed ID: 9822582
The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation.
Tang CJ, Tang TK
Blood. 1998
PubMed ID: 9694734
Functional association of nuclear protein 4.1 with pre-mRNA splicing factors.
Lallena MJ, Martínez C, Valcárcel J, Correas I
J Cell Sci. 1998
PubMed ID: 9645944
Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells.
Cohen AR, Woods DF, Marfatia SM, Walther Z, Chishti AH, Anderson JM, Wood DF
J Cell Biol. 1998
PubMed ID: 9660868
Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family.
Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG
Genomics. 1998
PubMed ID: 9598318
The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1.
Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH
J Cell Biol. 1998
PubMed ID: 9531554
Sequence, structure and chromosomal localization of Crtm gene encoding mouse cartilage matrix protein and its exclusion as a candidate for murine achondroplasia.
Aszódi A, Beier DR, Hiripi L, Bösze Z, Fässler R
Matrix Biol. 1998
PubMed ID: 9569124
Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells.
Avraham S, London R, Tulloch GA, Ellis M, Fu Y, Jiang S, White RA, Painter C, Steinberger AA, Avraham H
Gene. 1997
PubMed ID: 9434160
Paranodin, a glycoprotein of neuronal paranodal membranes.
Menegoz M, Gaspar P, Le Bert M, Galvez T, Burgaya F, Palfrey C, Ezan P, Arnos F, Girault JA
Neuron. 1997
PubMed ID: 9292722
Structural protein 4.1 is located in mammalian centrosomes.
Krauss SW, Chasis JA, Rogers C, Mohandas N, Krockmalnic G, Penman S
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207085
Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain.
Lue RA, Brandin E, Chan EP, Branton D
J Cell Biol. 1996
PubMed ID: 8922391
Genetic linkage of IgG autoantibody production in relation to lupus nephritis in New Zealand hybrid mice.
Vyse TJ, Drake CG, Rozzo SJ, Roper E, Izui S, Kotzin BL
J Clin Invest. 1996
PubMed ID: 8878426
Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation.
Baklouti F, Huang SC, Tang TK, Delaunay J, Marchesi VT, Benz EJ
Blood. 1996
PubMed ID: 8611723
ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.
Palmiter RD, Cole TB, Findley SD
EMBO J. 1996
PubMed ID: 8617223
Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrin-actin binding domain of erythroid protein 4.1.
Winardi R, Discher D, Kelley C, Zon L, Mays K, Mohandas N, Conboy JG
Blood. 1995
PubMed ID: 7492792
Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding.
Schischmanoff PO, Winardi R, Discher DE, Parra MK, Bicknese SE, Witkowska HE, Conboy JG, Mohandas N
J Biol Chem. 1995
PubMed ID: 7673158
Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.
Lue RA, Marfatia SM, Branton D, Chishti AH
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7937897
Structural diversity of band 4.1 superfamily members.
Takeuchi K, Kawashima A, Nagafuchi A, Tsukita S
J Cell Sci. 1994
PubMed ID: 7983158
Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.
Drake CG, Babcock SK, Palmer E, Kotzin BL
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8171035
Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing.
Huang JP, Tang CJ, Kou GH, Marchesi VT, Benz EJ, Tang TK
J Biol Chem. 1993
PubMed ID: 8429050
Structure, function, and molecular genetics of erythroid membrane skeletal protein 4.1 in normal and abnormal red blood cells.
Conboy JG
Semin Hematol. 1993
PubMed ID: 8434260
An isoform-specific mutation in the protein 4.1 gene results in hereditary elliptocytosis and complete deficiency of protein 4.1 in erythrocytes but not in nonerythroid cells.
Conboy JG, Chasis JA, Winardi R, Tchernia G, Kan YW, Mohandas N
J Clin Invest. 1993
PubMed ID: 8423235
Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene.
Dalla Venezia N, Gilsanz F, Alloisio N, Ducluzeau MT, Benz EJ, Delaunay J
J Clin Invest. 1992
PubMed ID: 1430200
Identification of the binding interface involved in linkage of cytoskeletal protein 4.1 to the erythrocyte anion exchanger.
Jöns T, Drenckhahn D
EMBO J. 1992
PubMed ID: 1639060
Molecular genetic linkage maps of mouse chromosomes 4 and 6.
Bahary N, Zorich G, Pachter JE, Leibel RL, Friedman JM
Genomics. 1991
PubMed ID: 1684952
Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro.
Subrahmanyam G, Bertics PJ, Anderson RA
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1647028
Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1.
Conboy JG, Chan JY, Chasis JA, Kan YW, Mohandas N
J Biol Chem. 1991
PubMed ID: 2022644
Identification of two cAMP-dependent phosphorylation sites on erythrocyte protein 4.1.
Horne WC, Prinz WC, Tang EK
Biochim Biophys Acta. 1990
PubMed ID: 2171679
Molecular analysis of insertion/deletion mutations in protein 4.1 in elliptocytosis. II. Determination of molecular genetic origins of rearrangements.
Conboy J, Marchesi S, Kim R, Agre P, Kan YW, Mohandas N
J Clin Invest. 1990
PubMed ID: 2384598
O-N-acetyl-D-glucosamine moiety on discrete peptide of multiple protein 4.1 isoforms regulated by alternative pathways.
Inaba M, Maede Y
J Biol Chem. 1989
PubMed ID: 2808371
Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.
Conboy JG, Chan J, Mohandas N, Kan YW
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3194408
Associations of human erythrocyte band 4.2. Binding to ankyrin and to the cytoplasmic domain of band 3.
Korsgren C, Cohen CM
J Biol Chem. 1988
PubMed ID: 2968981
Selective expression of an erythroid-specific isoform of protein 4.1.
Tang TK, Leto TL, Correas I, Alonso MA, Marchesi VT, Benz EJ
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3375238
Expression of specific isoforms of protein 4.1 in erythroid and non-erythroid tissues.
Tang TK, Leto TL, Marchesi VT, Benz EJ
Adv Exp Med Biol. 1988
PubMed ID: 3223413
Erythrocyte adducin: a calmodulin-regulated actin-bundling protein that stimulates spectrin-actin binding.
Mische SM, Mooseker MS, Morrow JS
J Cell Biol. 1987
PubMed ID: 3693401
Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton.
Conboy J, Kan YW, Shohet SB, Mohandas N
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3467321
Structure of the spectrin-actin binding site of erythrocyte protein 4.1.
Correas I, Speicher DW, Marchesi VT
J Biol Chem. 1986
PubMed ID: 3531202
Molecular basis of hereditary elliptocytosis due to protein 4.1 deficiency.
Conboy J, Mohandas N, Tchernia G, Kan YW
N Engl J Med. 1986
PubMed ID: 3755799
Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability.
Tchernia G, Mohandas N, Shohet SB
J Clin Invest. 1981
PubMed ID: 6894932

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2035	269587	313052
EnsEMBL Gene(s)	ENSG00000159023	ENSMUSG00000028906	ENSRNOG00000010037
Unigene	Hs.175437	Mm.30038	Rn.228573
Homologene	EPB41	Epb4.1	Epb4.1
OMIM	130500	N/A	N/A
GeneCards	EPB41	N/A	N/A
Beta Cell Genomics	DT.100718032 DT.100827924 DT.100827925 DT.100827927 DT.100827930 DT.101983016 DT.121441960 DT.121442050 DT.40301547 DT.444098 DT.92420651 DT.99939612	DT.101135582 DT.101167020 DT.101184062 DT.101196892 DT.103578306 DT.495370 DT.495373 DT.91335863 DT.94188944 DT.97354713 DT.97375477	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000290100	N/A	N/A
WikiGenes	2035	269587	313052

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
EPB41	LRPPRC	IntAct	empirical	17353931
EPB41	CDK2	IntAct, BioGRID	empirical	17353931
EPB41	PSME3	IntAct	empirical	17353931
EPB41	EIF1	IntAct	empirical	17353931
EPB41	CDKN2A	IntAct	empirical	17353931
EPB41	PAICS	IntAct, BioGRID	empirical	17353931
EPB41	ATP5L	IntAct	empirical	17353931
EPB41	RAB10	IntAct	empirical	17353931
EPB41	STIP1	IntAct	empirical	17353931
EPB41	YWHAQ	HPRD	empirical	16368544
EPB41	PHB2	IntAct	empirical	17353931
EPB41	U2AF2	HPRD	empirical	9645944
EPB41	CLIC1	IntAct	empirical	17353931
EPB41	CLNS1A	HPRD, MIPS	empirical	9694734
EPB41	COX5B	IntAct	empirical	17353931
EPB41	MTPN	IntAct	empirical	17353931
EPB41	CRYAB	HPRD	empirical	16368544
EPB41	CSTB	IntAct	empirical	17353931
EPB41	DAD1	IntAct	empirical	17353931
EPB41	DCTN1	BioGRID	empirical	10189366
EPB41	DHX9	IntAct	empirical	17353931
EPB41	DLG1	HPRD, BioGRID	empirical	7937897
EPB41	DYNC1H1	BioGRID	empirical	10189366
EPB41	DRD2	HPRD	empirical	12181426
EPB41	DRD3	HPRD	empirical	12181426
EPB41	ECHS1	IntAct, BioGRID	empirical	17353931
EPB41	EEF1B2	IntAct	empirical	17353931
EPB41	EGFR	HPRD	empirical	1647028
EPB41	EIF4G1	IntAct	empirical	17353931
EPB41	EPB42	HPRD	empirical	2968981
EPB41	AK2	IntAct	empirical	17353931
EPB41	FABP5	IntAct	empirical	17353931
EPB41	FHL1	IntAct	empirical	17353931
EPB41	FKBP1A	IntAct	empirical	17353931
EPB41	COPZ1	IntAct	empirical	17353931
EPB41	FKBP2	HPRD	empirical	9531554
EPB41	MAPRE1	IntAct	empirical	17353931
EPB41	SNRNP200	IntAct	empirical	17353931
EPB41	HIGD1A	IntAct	empirical	17353931
EPB41	TIMM13	IntAct	empirical	17353931
EPB41	GDI1	HPRD	empirical	16368544
EPB41	CACYBP	IntAct	empirical	17353931
EPB41	GOT2	IntAct	empirical	17353931
EPB41	MACROD1	HPRD	empirical	16368544
EPB41	GYPC	HPRD	empirical	11423550
EPB41	HADHA	IntAct	empirical	17353931
EPB41	HPRT1	IntAct	empirical	17353931
EPB41	HSPE1	IntAct	empirical	17353931
EPB41	APP	HPRD	empirical	16368544
EPB41	KPNA2	HPRD, BioGRID	empirical	10359596
EPB41	BCAM	HPRD	empirical	15238148
EPB41	SMAD3	HPRD, MINT	empirical	15527767
EPB41	RAB8A	IntAct	empirical	17353931
EPB41	MIF	IntAct	empirical	17353931
EPB41	MYH1	IntAct	empirical	17353931
EPB41	MYH9	IntAct, BioGRID	empirical	17353931
EPB41	MYH10	IntAct	empirical	17353931
EPB41	MYL1	HPRD	empirical	11071908
EPB41	NHP2L1	IntAct	empirical	17353931
EPB41	PNP	IntAct	empirical	17353931
EPB41	NPPA	BioGRID	empirical	12542678
EPB41	NUMA1	HPRD, MIPS, BioGRID	empirical	10189366
EPB41	PEBP1	IntAct	empirical	17353931
EPB41	PAFAH1B2	IntAct	empirical	17353931
EPB41	PCBD1	IntAct	empirical	17353931
EPB41	PCMT1	IntAct	empirical	17353931
EPB41	PCNA	IntAct	empirical	17353931
EPB41	TRMT112	IntAct	empirical	17353931
EPB41	PFAS	IntAct, BioGRID	empirical	17353931
EPB41	ACP1	IntAct	empirical	17353931
EPB41	PFN2	IntAct	empirical	17353931
EPB41	ATP6V1E1	IntAct	empirical	17353931
EPB41	PIN1	IntAct	empirical	17353931
EPB41	PIN4	IntAct	empirical	17353931
EPB41	ATP5O	IntAct	empirical	17353931
EPB41	CYCS	IntAct	empirical	17353931
EPB41	TMEM33	IntAct	empirical	17353931
EPB41	LRRC59	IntAct	empirical	17353931
EPB41	PRKCB	HPRD	empirical	15611095
EPB41	CENPJ	HPRD	empirical	11003675
EPB41	SAR1A	IntAct	empirical	17353931
EPB41	PSMA1	IntAct	empirical	17353931
EPB41	PSMA6	IntAct	empirical	17353931
EPB41	PSMA7	IntAct	empirical	17353931
EPB41	PSMB1	IntAct	empirical	17353931
EPB41	PSMB3	IntAct	empirical	17353931
EPB41	PSMB5	IntAct	empirical	17353931
EPB41	PSMB7	IntAct	empirical	17353931
EPB41	PSMC4	IntAct	empirical	17353931
EPB41	ACTA1	HPRD	empirical	11071908
EPB41	RAB2A	IntAct	empirical	17353931
EPB41	RAB5C	IntAct	empirical	17353931
EPB41	RANBP1	IntAct	empirical	17353931
EPB41	RPL38	IntAct	empirical	17353931
EPB41	RPS3A	IntAct	empirical	17353931
EPB41	RPS21	IntAct	empirical	17353931
EPB41	S100A11	IntAct	empirical	17353931
EPB41	SCP2	IntAct	empirical	17353931
EPB41	SEC14L1	HPRD	empirical	16368544
EPB41	SLC4A1	HPRD	empirical	1639060
EPB41	SPTAN1	HPRD, BioGRID	empirical	12049649 12044158
EPB41	SPTB	HPRD, BioGRID	empirical	7673158
EPB41	SPTBN1	HPRD	empirical	12901833
EPB41	SRP9	IntAct	empirical	17353931
EPB41	TCEB1	IntAct	empirical	17353931
EPB41	TPM1	HPRD	empirical	11071908
EPB41	TPM2	IntAct	empirical	17353931
EPB41	TPT1	IntAct	empirical	17353931
EPB41	TSN	IntAct	empirical	17353931
EPB41	TUBA4A	HPRD	empirical	15184364
EPB41	TUFM	IntAct	empirical	17353931
EPB41	TXN	IntAct	empirical	17353931
EPB41	U2AF1	HPRD	empirical	9645944
EPB41	UBC	BioGRID	empirical	21139048 21890473
EPB41	UBE2L3	IntAct	empirical	17353931
EPB41	UBE2V1	IntAct	empirical	17353931
EPB41	VARS	IntAct	empirical	17353931
EPB41	YWHAB	HPRD	empirical	16368544
EPB41	YWHAG	IntAct	empirical	17353931
EPB41	MRP63	IntAct	empirical	17353931
EPB41	CALR	IntAct, BioGRID	empirical	17353931
EPB41	SLIRP	IntAct	empirical	17353931
EPB41	DYNLRB1	IntAct	empirical	17353931
EPB41	TAGLN2	IntAct, BioGRID	empirical	17353931
EPB41	TXNDC17	IntAct	empirical	17353931
EPB41	CASK	HPRD, MINT, IntAct, BioGRID	empirical	9660868
EPB41	DYNLL1	IntAct	empirical	17353931
EPB41	EIF3G	HPRD, BioGRID	empirical	10887144
EPB41	SNX3	IntAct	empirical	17353931
EPB41	CBR1	IntAct	empirical	17353931
EPB41	RAB11B	IntAct	empirical	17353931
EPB41	VAMP3	IntAct	empirical	17353931
EPB41	TJP2	HPRD, BioGRID	empirical	10874042
EPB41	CD44	HPRD	empirical	12901833
EPB41	NUP155	IntAct	empirical	17353931
EPB41	C2CD2L	HPRD	empirical	16368544