A2M

Summary Top Help

Gene Description:

alpha-2-macroglobulin

Synonyms:

A2mp, A2MD, Mam, CPAMD5, A2maa, A2MAC1, A2M, S863-7, FWP007, A2m, A2m1, RATA2MAC1

Orthologs:

Human A2M (protein-coding), Mouse A2m (protein-coding), Rat A2m (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd19	Mouse	chr6:117439553..128469043	11.03	187	2 no lod score

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:9220260..9268825 (48.56 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:121586191..121629256 (436 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:158103689..158153423 (49.73 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for A2M:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for A2M:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: None available

Reactome: 9

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 19

Publications from PubMed Top Help

Publications: 235

Characterization of a novel positive transcription regulatory element that differentially regulates the alpha-2-macroglobulin gene in replicative senescence.
Li R, Ma L, Huang Y, Zhang Z, Tong T
Biogerontology. 2011
PubMed ID: 21541797
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Relationship between production of acute-phase proteins and strength of inflammatory stimulation in rats.
Kuribayashi T, Tomizawa M, Seita T, Tagata K, Yamamoto S
Lab Anim. 2011
PubMed ID: 21669904
During glaucoma, alpha2-macroglobulin accumulates in aqueous humor and binds to nerve growth factor, neutralizing neuroprotection.
Bai Y, Sivori D, Woo SB, Neet KE, Lerner SF, Saragovi HU
Invest Ophthalmol Vis Sci. 2011
PubMed ID: 21642630
Role of cardiac isoform of alpha-2 macroglobulin in diabetic myocardium.
Soman S, Manju CS, Rauf AA, Indira M, Rajamanickam C
Mol Cell Biochem. 2011
PubMed ID: 21188621
Modification of mouse A2M B (620-792) and A2M N (168-230) by malondialdehyde and acetaldehyde attenuates the proteinase and TGF-β1 binding ability of A2MB.
Kaur I, Katyal A
FEBS Lett. 2011
PubMed ID: 21320498
Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin.
Ozawa D, Hasegawa K, Lee YH, Sakurai K, Yanagi K, Ookoshi T, Goto Y, Naiki H
J Biol Chem. 2011
PubMed ID: 21216953
Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver.
Bogojević D, Poznanović G, Grdović N, Grigorov I, Vidaković M, Dinić S, Mihailović M
Radiat Environ Biophys. 2011
PubMed ID: 20848291
Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
Khalifé M, Young R, Passet B, Halliez S, Vilotte M, Jaffrezic F, Marthey S, Béringue V, Vaiman D, Le Provost F, Laude H, Vilotte JL
PLoS One. 2011
PubMed ID: 21858045
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
Mutat Res. 2010
PubMed ID: 20800603
Activated α(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines.
Cáceres LC, Bonacci GR, Sánchez MC, Chiabrando GA
J Cell Biochem. 2010
PubMed ID: 20568116
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.
Bruno E, Quattrocchi G, Nicoletti A, Le Pira F, Maci T, Mostile G, Andreoli V, Quattrone A, Zappia M
Neurosci Lett. 2010
PubMed ID: 20637261
Exploration of genetic susceptibility factors for Parkinson's disease in a South American sample.
Benitez BA, Forero DA, Arboleda GH, Granados LA, Yunis JJ, Fernandez W, Arboleda H
J Genet. 2010
PubMed ID: 20861575
Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.
Nalpas B, Lavialle-Meziani R, Plancoulaine S, Jouanguy E, Nalpas A, Munteanu M, Charlotte F, Ranque B, Patin E, Heath S, Fontaine H, Vallet-Pichard A, Pontoire D, Bourlière M, Casanova JL, Lathrop M, Bréchot C, Poynard T, Matsuda F, Pol S, Abel L
Gut. 2010
PubMed ID: 20587546
Association between haplotype -88G/25G in A2M with Alzheimer's disease.
Song H, Jia L, Zuo X, Jia J
Neurosci Lett. 2010
PubMed ID: 20493925
Application of champedak mannose-binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinoma.
Seriramalu R, Pang WW, Jayapalan JJ, Mohamed E, Abdul-Rahman PS, Bustam AZ, Khoo AS, Hashim OH
Electrophoresis. 2010
PubMed ID: 20575108
Proteomics of microparticles after deep venous thrombosis.
Ramacciotti E, Hawley AE, Wrobleski SK, Myers DD, Strahler JR, Andrews PC, Guire KE, Henke PK, Wakefield TW
Thromb Res. 2010
PubMed ID: 20156641
Surfactant protein D interacts with alpha2-macroglobulin and increases its innate immune potential.
Craig-Barnes HA, Doumouras BS, Palaniyar N
J Biol Chem. 2010
PubMed ID: 20207732
Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom.
Ghelani AM, Samanta A, Jones AC, Mastana SS
Rheumatol Int. 2010
PubMed ID: 20401725
ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy.
Domingues-Montanari S, Hernandez-Guillamon M, Fernandez-Cadenas I, Mendioroz M, Boada M, Munuera J, Rovira A, Maisterra O, Parés M, Gutierrez M, Alvarez-Sabin J, Chacón P, Delgado P, Montaner J, Stroke Project Cerebrovascular Diseases Study Group, Spanish Society of Neurology
Neurobiol Aging. 2010
PubMed ID: 20381197
Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling.
Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, Hollborn M, Thal D, Gebhardt R, Birkenmeier G
Cancer Res. 2010
PubMed ID: 20048078
Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake.
Yerbury JJ, Wilson MR
Cell Stress Chaperones. 2010
PubMed ID: 19472074
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell Stem Cell. 2009
PubMed ID: 19796622
Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals.
Flachsbart F, Caliebe A, Nothnagel M, Kleindorp R, Nikolaus S, Schreiber S, Nebel A
Eur J Hum Genet. 2009
PubMed ID: 19639019
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species.
Yerbury JJ, Kumita JR, Meehan S, Dobson CM, Wilson MR
J Biol Chem. 2009
PubMed ID: 19074141
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
J Proteome Res. 2009
PubMed ID: 19159218
Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration.
Benvegnù S, Franciotta D, Sussman J, Bachi A, Zardini E, Torreri P, Govaerts C, Pizzo S, Legname G
PLoS One. 2009
PubMed ID: 19536284
An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.
Edwards TL, Pericak-Vance M, Gilbert JR, Haines JL, Martin ER, Ritchie MD
Am J Med Genet B Neuropsychiatr Genet. 2008
PubMed ID: 19105203
Alpha2-macroglobulin is a mediator of retinal ganglion cell death in glaucoma.
Shi Z, Rudzinski M, Meerovitch K, Lebrun-Julien F, Birman E, Di Polo A, Saragovi HU
J Biol Chem. 2008
PubMed ID: 18701465
Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.
Zhou YT, Zhang ZX, Chan P, He XM, Tang MN, Wu CB, Hong Z
Neurosci Lett. 2008
PubMed ID: 18706476
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism.
Moriya M, Ho YH, Grana A, Nguyen L, Alvarez A, Jamil R, Ackland ML, Michalczyk A, Hamer P, Ramos D, Kim S, Mercer JF, Linder MC
Am J Physiol Cell Physiol. 2008
PubMed ID: 18579803
Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling.
Mantuano E, Mukandala G, Li X, Campana WM, Gonias SL
J Biol Chem. 2008
PubMed ID: 18499670
Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model.
Kendrick JE, Straughn JM, Oliver PG, Wang W, Nan L, Grizzle WE, Stockard CR, Alvarez RD, Buchsbaum DJ
Gynecol Oncol. 2008
PubMed ID: 18177927
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Is alpha2-macroglobulin important in female stress urinary incontinence?
Wen Y, Man WC, Sokol ER, Polan ML, Chen BH
Hum Reprod. 2008
PubMed ID: 18077315
Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism.
Anderson RB, Cianciolo GJ, Kennedy MN, Pizzo SV
J Leukoc Biol. 2008
PubMed ID: 17967834
Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity.
French K, Yerbury JJ, Wilson MR
Biochemistry. 2008
PubMed ID: 18171086
Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease.
Colacicco AM, Solfrizzi V, D'Introno A, Capurso C, Kehoe PG, Seripa D, Pilotto A, Santamato A, Capurso A, Panza F
Neurobiol Aging. 2008
PubMed ID: 18191876
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.
Tanskanen M, Peuralinna T, Polvikoski T, Notkola IL, Sulkava R, Hardy J, Singleton A, Kiuru-Enari S, Paetau A, Tienari PJ, Myllykangas L
Ann Med. 2008
PubMed ID: 18382889
Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.
Wilson MR, Yerbury JJ, Poon S
Mol Biosyst. 2008
PubMed ID: 18075673
Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3.
Doan N, Gettins PG
Biochem J. 2007
PubMed ID: 17608619
Role of elevated alpha2-macroglobulin revisited: results of a case-control study in children with symptomatic thromboembolism.
Beheiri A, Langer C, Düring C, Krümpel A, Thedieck S, Nowak-Göttl U
J Thromb Haemost. 2007
PubMed ID: 17403113
Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock.
Wielockx B, Staelens J, Puimège L, Vanlaere I, Van Roy M, van Lint P, Van Roy F, Libert C
J Immunol. 2007
PubMed ID: 17404289
Activated alpha(2)-macroglobulin induces cell proliferation and mitogen-activated protein kinase activation by LRP-1 in the J774 macrophage-derived cell line.
Bonacci GR, Cáceres LC, Sánchez MC, Chiabrando GA
Arch Biochem Biophys. 2007
PubMed ID: 17288987
STAT3/NFkappaB interplay in the regulation of alpha2-macroglobulin gene expression during rat liver development and the acute phase response.
Uskoković A, Dinić S, Mihailović M, Grigorov I, Ivanović-Matić S, Bogojević D, Grdović N, Arambasić J, Vidaković M, Martinović V, Petrović M, Poznanović G
IUBMB Life. 2007
PubMed ID: 17487688
Alpha2-macroglobulin is a potential facilitator of prion protein transformation.
Adler V, Davidowitz E, Tamburi P, Rojas P, Grossman A
Amyloid. 2007
PubMed ID: 17453620
The full-ORF clone resource of the German cDNA Consortium.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC Genomics. 2007
PubMed ID: 17974005
Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response.
Mihailović M, Dinić S, Bogojević D, Ivanović-Matić S, Uskoković A, Arambasić J, Grigorov I, Grdović N, Vidaković M, Martinović V, Petrović M, Poznanović G
Acta Biochim Pol. 2007
PubMed ID: 17565389
Inhibition of bone morphogenetic protein 1 by native and altered forms of alpha2-macroglobulin.
Zhang Y, Ge G, Greenspan DS
J Biol Chem. 2006
PubMed ID: 17071617
The role of interleukin-11 in pregnancy involves up-regulation of alpha2-macroglobulin gene through janus kinase 2-signal transducer and activator of transcription 3 pathway in the decidua.
Bao L, Devi S, Bowen-Shauver J, Ferguson-Gottschall S, Robb L, Gibori G
Mol Endocrinol. 2006
PubMed ID: 16959875
Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease.
Mariani E, Seripa D, Ingegni T, Nocentini G, Mangialasche F, Ercolani S, Cherubini A, Metastasio A, Pilotto A, Senin U, Mecocci P
J Neurol Sci. 2006
PubMed ID: 16784755
Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1.
Arandjelovic S, Van Sant CL, Gonias SL
J Biol Chem. 2006
PubMed ID: 16641085
Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease.
Depboylu C, Lohmüller F, Du Y, Riemenschneider M, Kurz A, Gasser T, Müller U, Dodel RC
Neurosci Lett. 2006
PubMed ID: 16650578
Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice.
Ghazalpour A, Wang X, Lusis AJ, Mehrabian M
Genetics. 2006
PubMed ID: 16624897
The identification of myocilin-associated proteins in the human trabecular meshwork.
Fautsch MP, Vrabel AM, Johnson DH
Exp Eye Res. 2006
PubMed ID: 16289162
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Interaction of mannan binding lectin with alpha2 macroglobulin via exposed oligomannose glycans: a conserved feature of the thiol ester protein family?
Arnold JN, Wallis R, Willis AC, Harvey DJ, Royle L, Dwek RA, Rudd PM, Sim RB
J Biol Chem. 2006
PubMed ID: 16407218
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes.
Reynolds CA, Prince JA, Feuk L, Brookes AJ, Gatz M, Pedersen NL
Behav Genet. 2006
PubMed ID: 16402284
The genetic association between alpha-2-macroglobulin (A2M) gene deletion polymorphism and low serum A2M concentration in overweight/obese Thais.
Rugsarash W, Tungtrongchitr R, Petmitr S, Phonrat B, Pongpaew P, Harnroongroj T, Tungtrongchitr A
Nutr Neurosci. 2006
PubMed ID: 16910174
[Association of the polymorphism in alpha-2 macroglobulin gene with essential tremor and Parkinson's disease]
Xiao Y, Zhang BS
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
PubMed ID: 16456795
Alpha-2-macroglobulin and albumin are useful serum proteins to detect subclinical peritonitis in the rat.
van Westrhenen R, Westra WM, van den Born J, Krediet RT, Keuning ED, Hiralall J, Dragt C, Hekking LH
Perit Dial Int. 2006
PubMed ID: 16538883
Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6.
Haines JL, Schnetz-Boutaud N, Schmidt S, Scott WK, Agarwal A, Postel EA, Olson L, Kenealy SJ, Hauser M, Gilbert JR, Pericak-Vance MA
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 16384981
Functions of alpha 2 macroglobulins in pregnancy.
Tayade C, Esadeg S, Fang Y, Croy BA
Mol Cell Endocrinol. 2005
PubMed ID: 16297527
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD
J Proteome Res. 2005
PubMed ID: 16335952
Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese.
Bian L, Yang JD, Guo TW, Duan Y, Qin W, Sun Y, Feng GY, He L
Biol Psychiatry. 2005
PubMed ID: 16040006
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.
Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP
Genes Dev. 2005
PubMed ID: 16103213
Ligation of cell surface-associated glucose-regulated protein 78 by receptor-recognized forms of alpha 2-macroglobulin: activation of p21-activated protein kinase-2-dependent signaling in murine peritoneal macrophages.
Misra UK, Sharma T, Pizzo SV
J Immunol. 2005
PubMed ID: 16081825
Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.
Misra UK, Deedwania R, Pizzo SV
J Biol Chem. 2005
PubMed ID: 15908432
Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.
Cai L, Tang G, Chen L, Zhang B, Jiang S, Ren D
Neuroreport. 2005
PubMed ID: 15931081
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway.
Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC
Cancer Cell. 2005
PubMed ID: 15950906
Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1.
Arandjelovic S, Hall BD, Gonias SL
Arch Biochem Biophys. 2005
PubMed ID: 15910735
Alpha(2) macroglobulin, a PSA binding protein, is expressed in human prostate stroma.
Lin VK, Wang SY, Boetticher NC, Vazquez DV, Saboorian H, McConnell JD, Roehrborn CG
Prostate. 2005
PubMed ID: 15611997
[No evidence for genetic association between alpha-2 macroglobulin I1000V polymorphism and sporadic Alzheimer's disease in two independent Chinese populations]
Sun Y, Shi J, Zhang S, Tang M, Liu X, Wang Y, Han H, Guo Y, Deng H, Zhao Z, Ma C
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 15793779
Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.
Pope SN, Lee IR
J Steroid Biochem Mol Biol. 2005
PubMed ID: 15862967
Characterization of a murine alpha 2 macroglobulin gene expressed in reproductive and cardiovascular tissue.
He H, McCartney DJ, Wei Q, Esadeg S, Zhang J, Foster RA, Hayes MA, Tayade C, Van Leuven F, Croy BA
Biol Reprod. 2005
PubMed ID: 15355875
Structural evaluation of plasma alpha2-macroglobulin in acute pancreatitis.
Bísaro de Lorenc L, Ramos AM, Sánchez MC, Montenegro R, Chiabrando GA
Clin Chem Lab Med. 2005
PubMed ID: 16232083
Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
Misra UK, Pizzo SV
J Cell Biochem. 2004
PubMed ID: 15389876
Significantly increased fractions of transformed to total alpha2-macroglobulin concentrations in plasma from patients with multiple sclerosis.
Jensen PE, Humle Jørgensen S, Datta P, Sørensen PS
Biochim Biophys Acta. 2004
PubMed ID: 15511627
alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.
Sukata T, Uwagawa S, Ozaki K, Sumida K, Kikuchi K, Kushida M, Saito K, Morimura K, Oeda K, Okuno Y, Mikami N, Fukushima S
Am J Pathol. 2004
PubMed ID: 15509519
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.
Ranganathan S, Liu CX, Migliorini MM, Von Arnim CA, Peltan ID, Mikhailenko I, Hyman BT, Strickland DK
J Biol Chem. 2004
PubMed ID: 15272003
Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.
Ling TY, Chen CL, Huang YH, Liu IH, Huang SS, Huang JS
J Biol Chem. 2004
PubMed ID: 15226301
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
The genetic association database.
Becker KG, Barnes KC, Bright TJ, Wang SA
Nat Genet. 2004
PubMed ID: 15118671
Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes.
Tortorella MD, Arner EC, Hills R, Easton A, Korte-Sarfaty J, Fok K, Wittwer AJ, Liu RQ, Malfait AM
J Biol Chem. 2004
PubMed ID: 14715656
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A
Mol Cell Proteomics. 2004
PubMed ID: 14718574
Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients.
Camelo D, Arboleda G, Yunis JJ, Pardo R, Arango G, Solano E, López L, Hedmont D, Arboleda H
J Neurol Sci. 2004
PubMed ID: 14759632
Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.
Zappia M, Manna I, Serra P, Cittadella R, Andreoli V, La Russa A, Annesi F, Spadafora P, Romeo N, Nicoletti G, Messina D, Gambardella A, Quattrone A
Arch Neurol. 2004
PubMed ID: 15023809
Gene expression profiles of livers from thermally injured rats.
Dasu MR, Cobb JP, Laramie JM, Chung TP, Spies M, Barrow RE
Gene. 2004
PubMed ID: 14960360
Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR
Proteomics. 2004
PubMed ID: 14760718
Association of alpha 2-macroglobulin polymorphisms and Alzheimer disease in Mainland Han Chinese.
Chen D, Zhang JW, Zhang ZX, Wu YN, Qu QM
J Neurol Sci. 2004
PubMed ID: 14675603
Neither the tumor necrosis factor alpha-308 A/G polymorphism nor the alpha2-macroglobulin polymorphism was associated with late-onset Alzheimer's disease in the Chinese population.
Zhang P, Yang Z, Wan CL, Zheng WD, Zhang CF, Li S, Lü ZP, Zheng CG, Jin F, Wang L
Yi Chuan Xue Bao. 2004
PubMed ID: 15468911
Complex formation between human kallikrein 13 and serum protease inhibitors.
Kapadia C, Yousef GM, Mellati AA, Magklara A, Wasney GA, Diamandis EP
Clin Chim Acta. 2004
PubMed ID: 14687906
Transcriptome analysis of mouse stem cells and early embryos.
Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS
PLoS Biol. 2003
PubMed ID: 14691545
Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion.
Hope C, Mettenburg J, Gonias SL, DeKosky ST, Kamboh MI, Chu CT
Neurobiol Dis. 2003
PubMed ID: 14678766
Human alpha2-macroglobulin: genotype-phenotype relation.
Birkenmeier G, Müller R, Huse K, Forberg J, Gläser C, Hedrich H, Nicklisch S, Reichenbach A
Exp Neurol. 2003
PubMed ID: 14637088
Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites.
Esadeg S, He H, Pijnenborg R, Van Leuven F, Croy BA
Placenta. 2003
PubMed ID: 14580373
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.
Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D
Hum Mol Genet. 2003
PubMed ID: 12966032
Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions.
Mathew S, Arandjelovic S, Beyer WF, Gonias SL, Pizzo SV
Biochem J. 2003
PubMed ID: 12755687
Simultaneous analysis of five genetic risk factors in Polish patients with Alzheimer's disease.
Styczynska M, Religa D, Pfeffer A, Luczywek E, Wasiak B, Styczynski G, Peplonska B, Gabryelewicz T, Golebiowski M, Kobrys M, Barcikowska M
Neurosci Lett. 2003
PubMed ID: 12782337
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
Shi Y, Massagué J
Cell. 2003
PubMed ID: 12809600
Inhibition of human pepsin and gastricsin by alpha2-macroglobulin.
Athauda SB, Nishigai M, Arakawa H, Ikai A, Ukai M, Takahashi K
J Enzyme Inhib Med Chem. 2003
PubMed ID: 14506912
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.
Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y
Genome Res. 2003
PubMed ID: 12819125
Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population.
Clarimón J, Bertranpetit J, Calafell F, Boada M, Tàrraga L, Comas D
Psychiatr Genet. 2003
PubMed ID: 12782964
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
Zhang H, Li XJ, Martin DB, Aebersold R
Nat Biotechnol. 2003
PubMed ID: 12754519
Growth factor-binding sequence in human alpha2-macroglobulin targets the receptor-binding site in transforming growth factor-beta.
Arandjelovic S, Freed TA, Gonias SL
Biochemistry. 2003
PubMed ID: 12755614
Disruption of structural and functional integrity of alpha 2-macroglobulin by cathepsin E.
Shibata M, Sakai H, Sakai E, Okamoto K, Nishishita K, Yasuda Y, Kato Y, Yamamoto K
Eur J Biochem. 2003
PubMed ID: 12631277
Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments.
Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Závodszky P
J Immunol. 2003
PubMed ID: 12538697
Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart.
Rajan S, Radhakrishnan J, Rajamanickam C
Basic Res Cardiol. 2003
PubMed ID: 12494268
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction.
Misra UK, Gonzalez-Gronow M, Gawdi G, Hart JP, Johnson CE, Pizzo SV
J Biol Chem. 2002
PubMed ID: 12194978
Carbon dioxide pneumoperitoneum alters acute-phase response induced by lipopolysaccharide.
Are C, Talamini MA, Murata K, De Maio A
Surg Endosc. 2002
PubMed ID: 12042906
The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
Misra UK, Akabani G, Pizzo SV
J Biol Chem. 2002
PubMed ID: 12114513
Genetic association of alpha2-macroglobulin polymorphisms with AD in southern Italy.
Zappia M, Cittadella R, Manna I, Nicoletti G, Andreoli V, Bonavita S, Gambardella A, Quattrone A
Neurology. 2002
PubMed ID: 12221172
Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.
Waghabi MC, Coutinho CM, Soeiro MN, Pereira MC, Feige JJ, Keramidas M, Cosson A, Minoprio P, Van Leuven F, Araújo-Jorge TC
Infect Immun. 2002
PubMed ID: 12183561
No evidence of association between the alpha-2 macroglobulin gene and Parkinson's disease in a case-control sample.
Nicoletti G, Annesi G, Tomaino C, Spadafora P, Pasqua AA, Annesi F, Serra P, Caracciolo M, Messina D, Zappia M, Quattrone A
Neurosci Lett. 2002
PubMed ID: 12123860
The three-dimensional structure of the human alpha 2-macroglobulin dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes.
Kolodziej SJ, Wagenknecht T, Strickland DK, Stoops JK
J Biol Chem. 2002
PubMed ID: 12015318
Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.
González P, Alvarez R, Reguero JR, Batalla A, Alvarez V, Cortina A, Cubero GI, García-Castro M, Coto E
Coron Artery Dis. 2002
PubMed ID: 12394648
DNA binding activity of C/EBPbeta and C/EBPdelta for the rat alpha2-macroglobulin gene promoter is regulated in an acute-phase dependent manner.
Milosavljevic TS, Petrovic MV, Cvetkovic ID, Grigorov II
Biochemistry (Mosc). 2002
PubMed ID: 12223092
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes.
Ghebremedhin E, Schultz C, Thal DR, Del Tredici K, Rueb U, Braak H
Neuropathol Appl Neurobiol. 2002
PubMed ID: 12175343
Transplacental transport of alpha 2-macroglobulin (alpha 2M) and induction of alpha 2M in maternal and neonatal rats with acute inflammation.
Shimizu M, Jinbo T, Kashiwazaki N, Kuribayashi T, Nomura M, Yamamoto S
Exp Anim. 2002
PubMed ID: 12221929
Ovarian hyperstimulation syndrome and assisted reproductive technologies: why some and not others?
McElhinney B, Ardill J, Caldwell C, Lloyd F, McClure N
Hum Reprod. 2002
PubMed ID: 12042276
alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.
Qiu Z, Strickland DK, Hyman BT, Rebeck GW
J Biol Chem. 2002
PubMed ID: 11839752
Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.
Mettenburg JM, Webb DJ, Gonias SL
J Biol Chem. 2002
PubMed ID: 11823454
Alpha2-macroglobulin deletion polymorphism and plasma levels in late onset Alzheimer's disease.
Scacchi R, Ruggeri M, Gambina G, Martini MC, Corbo RM
Clin Chem Lab Med. 2002
PubMed ID: 12059070
Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma.
Cvirn G, Gallistl S, Koestenberger M, Kutschera J, Leschnik B, Muntean W
Thromb Res. 2002
PubMed ID: 12062545
Relevance of variants in serum antiproteinases for the course of chronic pancreatitis.
Teich N, Walther K, Bödeker H, Mössner J, Keim V
Scand J Gastroenterol. 2002
PubMed ID: 11916201
Alpha2-macroglobulin exon 24 (Val-1000-Ile) polymorphism is not associated with late-onset sporadic Alzheimer's dementia in the Hungarian population.
Janka Z, Juhász A, Rimanóczy A, Boda K, Márki-Zay J, Palotás M, Kuk I, Zöllei M, Jakab K, Kálmán J
Psychiatr Genet. 2002
PubMed ID: 11901360
Differential binding properties of human pregnancy zone protein- and alpha2-macroglobulin-proteinase complexes to low-density lipoprotein receptor-related protein.
Chiabrando GA, Vides MA, Sánchez MC
Arch Biochem Biophys. 2002
PubMed ID: 11811950
Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models.
Tygstrup N, Bangert K, Ott P, Bisgaard HC
Biochem Biophys Res Commun. 2002
PubMed ID: 11779202
Cancer-related anemia in a rat model: alpha2-macroglobulin from Yoshida sarcoma shortens erythrocyte survival.
Bhanushali AA, Raghunathan R, Kalraiya RD, Mehta NG
Eur J Haematol. 2002
PubMed ID: 11952820
[Alpha2-macroglobulin gene polymorphism in patients with Alzheimer's disease]
Styczyńska M, Wasiak B, Łuczywek E, Pfeffer A, Barcikowska M
Neurol Neurochir Pol. 2001
PubMed ID: 11987698
Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease.
Nicosia F, Alberici A, Benussi L, Gasparini L, Ghidoni R, Mazzoli F, Zanetti O, Frisoni GB, Geroldi C, Binetti G
Dement Geriatr Cogn Disord. 2001
PubMed ID: 11455130
Interaction of lecithin:cholesterol acyltransferase (LCAT).alpha 2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an alpha 2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance.
Krimbou L, Marcil M, Davignon J, Genest J
J Biol Chem. 2001
PubMed ID: 11435418
No association of three polymorphisms in the alpha-2-macroglobulin and lipoprotein related receptor genes with multiple sclerosis.
Schweer D, Jacobsen M, Ziegler A, Jäkel S, Oertel WH, Sommer N, Hemmer B
J Neuroimmunol. 2001
PubMed ID: 11498265
Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern Ireland.
McIlroy SP, Dynan KB, Vahidassr DJ, Lawson JT, Patterson CC, Passmore P
Am J Med Genet. 2001
PubMed ID: 11496365
[No evidence for association between the alpha 2-macroglobulin polymorphism and Alzheimer's disease in the Han Chinese]
Shi J, Ma C, Lao H, Feng R, Guo Y, Mu N, Li Q, Tan Y, Wang D
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001
PubMed ID: 11484172
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Prince JA, Feuk L, Sawyer SL, Gottfries J, Ricksten A, Nägga K, Bogdanovic N, Blennow K, Brookes AJ
Eur J Hum Genet. 2001
PubMed ID: 11436125
Alfimeprase: pharmacology of a novel fibrinolytic metalloproteinase for thrombolysis.
Toombs CF
Haemostasis. 2001
PubMed ID: 11910179
Alpha-1 antichymotrypsin and alpha-2 macroglobulin gene polymorphisms are not associated with Korean late-onset Alzheimer's disease.
Ki CS, Na DL, Kim HJ, Kim JW
Neurosci Lett. 2001
PubMed ID: 11290389
Alpha2-macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease.
Nacmias B, Tedde A, Cellini E, Forleo P, Orlacchio A, Guarnieri BM, Petruzzi C, D'Andrea F, Serio A, Sorbi S
Neurosci Lett. 2001
PubMed ID: 11166925
Association of alpha-2-macroglobulin deletion polymorphism with sporadic Alzheimer's disease in Koreans.
Jhoo JH, Kim KW, Lee DY, Lee KU, Lee JH, Kim SY, Youn JY, Youn JC, Woo JI
J Neurol Sci. 2001
PubMed ID: 11231028
Lack of association between alpha2-macroglobulin polymorphisms and Alzheimer's disease.
Wang X, Luedecking EK, Minster RL, Ganguli M, DeKosky ST, Kamboh MI
Hum Genet. 2001
PubMed ID: 11281447
Expression and enzymatic activity of human disintegrin and metalloproteinase ADAM19/meltrin beta.
Wei P, Zhao YG, Zhuang L, Ruben S, Sang QX
Biochem Biophys Res Commun. 2001
PubMed ID: 11162584
Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population.
Bagli M, Papassotiropoulos A, Jessen F, Schmitz S, Rao ML, Maier W, Heun R
Am J Med Genet. 2000
PubMed ID: 11121179
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.
Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ
Nat Med. 2000
PubMed ID: 11100124
Genetic risk factors of sporadic Alzheimer's disease among Chinese in Taiwan.
Hu CJ, Sung SM, Liu HC, Hsu WC, Lee LS, Lee CC, Tsai CH, Chang JG
J Neurol Sci. 2000
PubMed ID: 11099722
Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patients.
Zill P, Bürger K, Behrens S, Hampel H, Padberg F, Boetsch T, Möller HJ, Ackenheil M, Bondy B
Neurosci Lett. 2000
PubMed ID: 11058789
alpha2-macroglobulin modulates the immunoregulatory function of the lipocalin placental protein 14.
Riely GJ, Rachmilewitz J, Koo PH, Tykocinski ML
Biochem J. 2000
PubMed ID: 11023837
A DNA polymorphism at the alpha2-macroglobulin gene is associated with the severity of rheumatoid arthritis.
Zapico I, Coto E, Rodríguez A, Alvarez C, Torre JC, Alvarez V
J Rheumatol. 2000
PubMed ID: 11036822
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages.
Kurdowska A, Alden SM, Noble JM, Stevens MD, Carr FK
Cytokine. 2000
PubMed ID: 10880251
Sequence-ready BAC contig, physical, and transcriptional map of a 2-Mb region overlapping the mouse chromosome 6 host-resistance locus Cmv1.
Depatie C, Lee SH, Stafford A, Avner P, Belouchi A, Gros P, Vidal SM
Genomics. 2000
PubMed ID: 10860661
alpha2-Macroglobulin, the main serum antiprotease, binds beta2-microglobulin, the light chain of the class I major histocompatibility complex, which is involved in human disease.
Gouin-Charnet A, Laune D, Granier C, Mani JC, Pau B, Mourad G, Argilés A
Clin Sci (Lond). 2000
PubMed ID: 10731476
Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta.
Gonias SL, Carmichael A, Mettenburg JM, Roadcap DW, Irvin WP, Webb DJ
J Biol Chem. 2000
PubMed ID: 10681572
NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.
Dolmer K, Huang W, Gettins PG
J Biol Chem. 2000
PubMed ID: 10652313
Interleukin-4 and IL-10 bind covalently to activated human alpha2-macroglobulin by a mechanism that requires Cys949.
Garber TR, Gonias SL, Webb DJ
J Interferon Cytokine Res. 2000
PubMed ID: 10714547
Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene cluster on mouse chromosome 6.
Brown MG, Zhang J, Du Y, Stoll J, Yokoyama WM, Scalzo AA
J Immunol. 1999
PubMed ID: 10438936
ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix.
Kuno K, Terashima Y, Matsushima K
J Biol Chem. 1999
PubMed ID: 10373500
Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK.
Dow DJ, Lindsey N, Cairns NJ, Brayne C, Robinson D, Huppert FA, Paykel ES, Xuereb J, Wilcock G, Whittaker JL, Rubinsztein DC
Nat Genet. 1999
PubMed ID: 10319853
Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin.
Huang W, Dolmer K, Liao X, Gettins PG
Protein Sci. 1998
PubMed ID: 9865955
Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat.
Andrejko KM, Chen J, Deutschman CS
Am J Physiol. 1998
PubMed ID: 9843780
Association of apolipoprotein E with alpha2-macroglobulin in human plasma.
Krimbou L, Tremblay M, Davignon J, Cohn JS
J Lipid Res. 1998
PubMed ID: 9831625
Human leptin forms complexes with alpha 2-macroglobulin which are recognized by the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein.
Birkenmeier G, Kämpfer I, Kratzsch J, Schellenberger W
Eur J Endocrinol. 1998
PubMed ID: 9724081
A modified human alpha 2-macroglobulin derivative that binds tumor necrosis factor-alpha and interleukin-1 beta with high affinity in vitro and reverses lipopolysaccharide toxicity in vivo in mice.
Webb DJ, Gonias SL
Lab Invest. 1998
PubMed ID: 9714181
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
Blacker D, Wilcox MA, Laird NM, Rodes L, Horvath SM, Go RC, Perry R, Watson B, Bassett SS, McInnis MG, Albert MS, Hyman BT, Tanzi RE
Nat Genet. 1998
PubMed ID: 9697696
Induction and modulation of acute-phase response by protein malnutrition in rats: comparative effect of systemic and localized inflammation on interleukin-6 and acute-phase protein synthesis.
Lyoumi S, Tamion F, Petit J, Déchelotte P, Dauguet C, Scotté M, Hiron M, Leplingard A, Salier JP, Daveau M, Lebreton JP
J Nutr. 1998
PubMed ID: 9446838
Human glandular kallikrein, hK2, shows arginine-restricted specificity and forms complexes with plasma protease inhibitors.
Mikolajczyk SD, Millar LS, Kumar A, Saedi MS
Prostate. 1998
PubMed ID: 9428387
Human alpha 2-macroglobulin is an osteogenic growth peptide-binding protein.
Gavish H, Bab I, Tartakovsky A, Chorev M, Mansur N, Greenberg Z, Namdar-Attar M, Muhlrad A
Biochemistry. 1997
PubMed ID: 9398211
Interaction of matrix metalloproteinases-2 and -9 with pregnancy zone protein and alpha2-macroglobulin.
Arbeláez LF, Bergmann U, Tuuttila A, Shanbhag VP, Stigbrand T
Arch Biochem Biophys. 1997
PubMed ID: 9344465
The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.
Arai Y, Hosoda F, Kobayashi H, Arai K, Hayashi Y, Kamada N, Kaneko Y, Ohki M
Blood. 1997
PubMed ID: 9166830
A 2-Mb YAC contig and physical map of the natural killer gene complex on mouse chromosome 6.
Brown MG, Fulmek S, Matsumoto K, Cho R, Lyons PA, Levy ER, Scalzo AA, Yokoyama WM
Genomics. 1997
PubMed ID: 9177771
The Cmv1 host resistance locus is closely linked to the Ly49 multigene family within the natural killer cell gene complex on mouse chromosome 6.
Forbes CA, Brown MG, Cho R, Shellam GR, Yokoyama WM, Scalzo AA
Genomics. 1997
PubMed ID: 9169139
High-resolution linkage map in the proximity of the host resistance locus Cmv1.
Depatie C, Muise E, Lepage P, Gros P, Vidal SM
Genomics. 1997
PubMed ID: 9027502
Molecular cloning of Limulus alpha 2-macroglobulin.
Iwaki D, Kawabata S, Miura Y, Kato A, Armstrong PB, Quigley JP, Nielsen KL, Dolmer K, Sottrup-Jensen L, Iwanaga S
Eur J Biochem. 1996
PubMed ID: 9022715
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein.
Valnickova Z, Thogersen IB, Christensen S, Chu CT, Pizzo SV, Enghild JJ
J Biol Chem. 1996
PubMed ID: 8662763
Identification of residues in alpha-macroglobulins important for binding to the alpha2-macroglobulin receptor/Low density lipoprotein receptor-related protein.
Nielsen KL, Holtet TL, Etzerodt M, Moestrup SK, Gliemann J, Sottrup-Jensen L, Thogersen HC
J Biol Chem. 1996
PubMed ID: 8662686
Complex formation between PSA isoenzymes and protease inhibitors.
Leinonen J, Zhang WM, Stenman UH
J Urol. 1996
PubMed ID: 8583572
alpha 1-Microglobulin destroys the proteinase inhibitory activity of alpha 1-inhibitor-3 by complex formation.
Falkenberg C, Allhorn M, Thøgersen IB, Valnickova Z, Pizzo SV, Salvesen G, Akerström B, Enghild JJ
J Biol Chem. 1995
PubMed ID: 7533162
Alpha 2-macroglobulin production by the human endometrium.
Sayegh R, Awwad JT, Maxwell C, Lessey B, Isaacson K
J Clin Endocrinol Metab. 1995
PubMed ID: 7533769
The cleavage of the bait region of alpha 2-macroglobulin by human immunodeficiency virus proteinases and by astacin.
Meier UC, Boetzel J, Kellermann J, Mann K, Billich A, Stöcker W, Schramm HJ
Ann N Y Acad Sci. 1994
PubMed ID: 7524416
Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma.
Falkenberg C, Enghild JJ, Thøgersen IB, Salvesen G, Akerström B
Biochem J. 1994
PubMed ID: 7519849
Entrapment and inhibition of human immunodeficiency virus proteinase by alpha 2-macroglobulin and structural changes in the inhibitor.
Athauda SB, Ido E, Arakawa H, Nishigai M, Kyushiki H, Yoshinaka Y, Takahashi T, Ikai A, Tang J, Takahashi K
J Biochem. 1993
PubMed ID: 7690356
Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.
Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S
Biochim Biophys Acta. 1993
PubMed ID: 8485155
Mannose-specific lectins bind alpha-2-macroglobulin and an unknown protein from human plasma.
Van Leuven F, Torrekens S, Van Damme E, Peumans W, Van den Berghe H
Protein Sci. 1993
PubMed ID: 7680268
Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics.
Borth W
FASEB J. 1992
PubMed ID: 1281457
The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA.
van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H
Eur J Biochem. 1992
PubMed ID: 1280217
Structure of the human alpha-2 macroglobulin gene and its promotor.
Matthijs G, Devriendt K, Cassiman JJ, Van den Berghe H, Marynen P
Biochem Biophys Res Commun. 1992
PubMed ID: 1374237
Assignment of mouse alpha-2-macroglobulin gene to chromosome 6 band F1-G3.
Hilliker C, Overbergh L, Petit P, Van Leuven F, Van den Berghe H
Mamm Genome. 1992
PubMed ID: 1379499
Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.
Poller W, Faber JP, Klobeck G, Olek K
Hum Genet. 1992
PubMed ID: 1370808
alpha 2-Macroglobulin is cleaved by HIV-1 protease in the bait region but not in the C-terminal inter-domain region.
Meier UC, Billich A, Mann K, Schramm HJ, Schramm W
Biol Chem Hoppe Seyler. 1991
PubMed ID: 1724156
Sequence of rat alpha 1-macroglobulin, a broad-range proteinase inhibitor from the alpha-macroglobulin-complement family.
Eggertsen G, Hudson G, Shiels B, Reed D, Fey GH
Mol Biol Med. 1991
PubMed ID: 1725450
Sequence polymorphism in the human alpha-2-macroglobulin (A2M) gene.
Poller W, Faber JP, Olek K
Nucleic Acids Res. 1991
PubMed ID: 1707161
Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors.
Christensson A, Laurell CB, Lilja H
Eur J Biochem. 1990
PubMed ID: 1702714
Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue.
Falkenberg C, Grubb A, Akerström B
J Biol Chem. 1990
PubMed ID: 1697852
A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.
Marynen P, Devriendt K, Van den Berghe H, Cassiman JJ
FEBS Lett. 1990
PubMed ID: 1692292
Interaction of lysosomal cysteine proteinases with alpha 2-macroglobulin: conclusive evidence for the endopeptidase activities of cathepsins B and H.
Mason RW
Arch Biochem Biophys. 1989
PubMed ID: 2476070
Detection of an alteration of the alpha 2-macroglobulin gene in a patient with chronic lung disease and serum alpha 2-macroglobulin deficiency.
Poller W, Barth J, Voss B
Hum Genet. 1989
PubMed ID: 2475424
Identification of alpha 2-macroglobulin as a cytokine binding plasma protein. Binding of interleukin-1 beta to "F" alpha 2-macroglobulin.
Borth W, Luger TA
J Biol Chem. 1989
PubMed ID: 2466831
Identification of the promoter sequences involved in the interleukin-6 dependent expression of the rat alpha 2-macroglobulin gene.
Kunz D, Zimmermann R, Heisig M, Heinrich PC
Nucleic Acids Res. 1989
PubMed ID: 2466233
Detection of lysozyme and alpha 2-macroglobulin--lysozyme complexes by immunoblotting.
Mörsky P
Clin Chim Acta. 1988
PubMed ID: 2467766
Structure and acute-phase regulation of the rat alpha 2-macroglobulin gene.
Northemann W, Shiels BR, Braciak TA, Hanson RW, Heinrich PC, Fey GH
Biochemistry. 1988
PubMed ID: 2468362
Synthesis and localization of plasma proteins in the developing human brain. Integrity of the fetal blood-brain barrier to endogenous proteins of hepatic origin.
Møllgård K, Dziegielewska KM, Saunders NR, Zakut H, Soreq H
Dev Biol. 1988
PubMed ID: 3289986
The polymorphic human alpha 2-macroglobulin gene (A2M) is located in chromosome region 12p12.3----p13.3.
Fukushima Y, Bell GI, Shows TB
Cytogenet Cell Genet. 1988
PubMed ID: 2460294
[Comparison of protein concentrations in saliva and serum]
Grimoud AM, Pontet F, Rousselet F, Lodter JP, Duffaut D, Seguela JP
Ann Biol Clin (Paris). 1988
PubMed ID: 2459995
Kupffer cell stimulation of alpha 2-macroglobulin synthesis in rat hepatocytes and the role of glucocorticoid.
Kurokawa S, Ishibashi H, Hayashida K, Tsuchiya Y, Hirata Y, Sakaki Y, Okubo H, Niho Y
Cell Struct Funct. 1987
PubMed ID: 2436819
Sequence of rat liver alpha 2-macroglobulin and acute phase control of its messenger RNA.
Gehring MR, Shiels BR, Northemann W, de Bruijn MH, Kan CC, Chain AC, Noonan DJ, Fey GH
J Biol Chem. 1987
PubMed ID: 2432068
Sequence analysis of the putative regulatory region of rat alpha 2-macroglobulin gene.
Tsuchiya Y, Hattori M, Hayashida K, Ishibashi H, Okubo H, Sakaki Y
Gene. 1987
PubMed ID: 2448189
Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.
Jensen PE, Sottrup-Jensen L
J Biol Chem. 1986
PubMed ID: 2430963
Molecular cloning of DNA complementary to rat alpha 2-macroglobulin mRNA.
Hayashida K, Okubo H, Noguchi M, Yoshida H, Kangawa K, Matsuo H, Sakaki Y
J Biol Chem. 1985
PubMed ID: 2414291
Molecular cloning of cDNA sequences for rat alpha 2-macroglobulin and measurement of its transcription during experimental inflammation.
Northemann W, Heisig M, Kunz D, Heinrich PC
J Biol Chem. 1985
PubMed ID: 2581948
Human alpha 2-macroglobulin gene is located on chromosome 12.
Bell GI, Rall LB, Sanchez-Pescador R, Merryweather JP, Scott J, Eddy RL, Shows TB
Somat Cell Mol Genet. 1985
PubMed ID: 2408344
Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.
Kan CC, Solomon E, Belt KT, Chain AC, Hiorns LR, Fey G
Proc Natl Acad Sci U S A. 1985
PubMed ID: 2581245
Primary structure of human alpha 2-macroglobulin. V. The complete structure.
Sottrup-Jensen L, Stepanik TM, Kristensen T, Wierzbicki DM, Jones CM, Lønblad PB, Magnusson S, Petersen TE
J Biol Chem. 1984
PubMed ID: 6203908
Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluid.
Rinderknecht H, Renner IG, Abramson SB, Carmack C
Gastroenterology. 1984
PubMed ID: 6698368
Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.
Virca GD, Salvesen GS, Travis J
Hoppe Seylers Z Physiol Chem. 1983
PubMed ID: 6195065
Radioimmunoassay of human pancreatic elastase 1. In vitro interaction of human pancreatic elastase 1 with serum protease inhibitors.
Murata A, Ogawa M, Fujimoto K, Kitahara T, Matsuda Y, Kosaki G
Enzyme. 1983
PubMed ID: 6191979
Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue.
Hudson NW, Koo PH
Biochim Biophys Acta. 1982
PubMed ID: 6179545
Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.
Mortensen SB, Sottrup-Jensen L, Hansen HF, Petersen TE, Magnusson S
FEBS Lett. 1981
PubMed ID: 6172288
Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.
Sottrup-Jensen L, Lønblad PB, Stepanik TM, Petersen TE, Magnusson S, Jörnvall H
FEBS Lett. 1981
PubMed ID: 6165619
Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.
Hall PK, Nelles LP, Travis J, Roberts RC
Biochem Biophys Res Commun. 1981
PubMed ID: 6167263
Interaction between human pancreatic elastase and plasma protease inhibitors.
Gustavsson EL, Ohlsson K, Olsson AS
Hoppe Seylers Z Physiol Chem. 1980
PubMed ID: 6153632
[Uniform method for determining the alpha 1-antitrypsin and alpha 2-macroglobulin activity in human blood serum (plasma)]
Nartikova VF, Paskhina TS
Vopr Med Khim. 1979
PubMed ID: 89758
The in vitro interactions of rat pancreatic elastase and normal and inflammatory ray serum.
Gauthier F, Genell S, Mouray H, Ohlsson K
Biochim Biophys Acta. 1978
PubMed ID: 80233
Platelet alpha2-macroglobulin and alpha1-antitrypsin.
Nachman RL, Harpel PC
J Biol Chem. 1976
PubMed ID: 59727

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2	232345	24153
EnsEMBL Gene(s)	ENSG00000175899	ENSMUSG00000030111	ENSRNOG00000028896
Unigene	Hs.212838	Mm.30151	Rn.225884
Homologene	A2M	A2m	A2m
OMIM	103950	N/A	N/A
GeneCards	A2M	N/A	N/A
Beta Cell Genomics	DT.100034913 DT.100708503 DT.100708507 DT.95325241 DT.95336010 DT.95336016	DT.97396488	N/A
Reactome	P01023	N/A	N/A
Plasma Peptide Atlas	ENSP00000261336	N/A	N/A
WikiGenes	2	232345	24153

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
A2M	CDKN1A	BioGRID	empirical	21900206
A2M	CDK2AP2	BioGRID	empirical	21900206
A2M	MGEA5	IntAct	empirical	21163940
A2M	C11orf58	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
A2M	NUDT21	BioGRID	empirical	21900206
A2M	RPP14	BioGRID	empirical	21900206
A2M	SPACA3	IntAct	empirical	2467766
A2M	TRAPPC5	IntAct	empirical	21163940
A2M	CPB2	BioGRID	empirical	8662763
A2M	RNF32	IntAct	empirical	21163940
A2M	CTSB	HPRD	empirical	2476070
A2M	CTSE	HPRD	empirical	12631277
A2M	CYP2C8	IntAct	empirical	21163940
A2M	CYP2C18	IntAct	empirical	21163940
A2M	CELA1	HPRD	empirical	6153632 6191979 80233
A2M	ELAVL3	IntAct	empirical	21163940
A2M	FARSA	IntAct	empirical	21163940
A2M	PAXIP1	IntAct	empirical	21163940
A2M	MAST1	IntAct	empirical	21163940
A2M	NCDN	IntAct	empirical	21163940
A2M	SEPT8	BioGRID	empirical	21900206
A2M	IFIT5	IntAct	empirical	21163940
A2M	AMBP	HPRD, BioGRID	empirical	7519849 7533162 1697852
A2M	KLK13	BioGRID	empirical	14687906
A2M	GCDH	IntAct	empirical	21163940
A2M	GEM	IntAct, BioGRID	empirical	18624398
A2M	GRB2	IntAct, BioGRID	empirical	18624398
A2M	H2AFX	BioGRID	empirical	21900206
A2M	ANXA6	HPRD	empirical	15226301
A2M	ANXA7	BioGRID	empirical	21900206
A2M	HMOX2	BioGRID	empirical	21900206
A2M	HSPA5	HPRD, BioGRID	empirical	12194978
A2M	IFIT3	IntAct	empirical	21163940
A2M	APOE	HPRD, IntAct, BioGRID	empirical	9831625 21163940
A2M	APP	IntAct	empirical	21163940
A2M	KLK3	HPRD, BioGRID	empirical	8583572 1702714
A2M	IL1B	HPRD	empirical	9714181 2466831
A2M	IL4	BioGRID	empirical	10714547
A2M	IL10	HPRD, BioGRID	empirical	10714547
A2M	KLK2	HPRD	empirical	9428387
A2M	LCAT	HPRD, BioGRID	empirical	11435418
A2M	LEP	HPRD, BioGRID	empirical	9724081
A2M	LRP1	HPRD, BioGRID	empirical	10652313 12194978
A2M	LYZ	HPRD	empirical	2467766
A2M	MMP2	HPRD, BioGRID	empirical	9344465
A2M	MYOC	HPRD	empirical	16289162
A2M	NGF	HPRD, BioGRID	empirical	10681572
A2M	NOS3	IntAct	empirical	21163940
A2M	PAEP	HPRD, BioGRID	empirical	11023837
A2M	EXOSC1	IntAct	empirical	21163940
A2M	ECSIT	IntAct	empirical	21163940
A2M	PDGFA	HPRD	empirical	10681572
A2M	PDGFB	HPRD	empirical	10681572
A2M	ATF7IP	HPRD	empirical	15231748
A2M	B2M	HPRD, BioGRID	empirical	10731476
A2M	RAD23A	IntAct	empirical	21163940
A2M	RAP1B	BioGRID	empirical	21900206
A2M	RHEB	IntAct	empirical	21163940
A2M	MLST8	IntAct	empirical	21163940
A2M	SHBG	HPRD	empirical	15862967
A2M	PRDX2	IntAct	empirical	21163940
A2M	TGFBI	HPRD	empirical	10681572
A2M	TGIF1	BioGRID	empirical	21900206
A2M	TGM2	IntAct	empirical	21988832
A2M	TTR	BioGRID	empirical	21900206
A2M	UFD1L	BioGRID	empirical	21900206
A2M	UMPS	IntAct	empirical	21163940
A2M	PRAM1	IntAct	empirical	21163940
A2M	TP63	IntAct	empirical	20085233
A2M	TNFRSF14	BioGRID	empirical	21900206
A2M	TSC22D1	BioGRID	empirical	21900206
A2M	LONP1	IntAct	empirical	21163940
A2M	ADAMTS1	HPRD, BioGRID	empirical	10373500
A2M	CDC42	IntAct, BioGRID	empirical	18624398