Home EIF4G1
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Regions Overlapping this Feature:
Rat: 1
Linkage Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Iddm17 | Rat | chr11:19445919..87759784 | 68.31 | 594 |
(Human) GRCh37 - chr3:184032283..184053146 (20.86 kb) View in Genome Browser
(Mouse) NCBIM37 - chr16:20668386..20692957 (24.57 kb) View in Genome Browser
(Rat) RGSC3.4 - chr11:82451555..82471735 (20.18 kb) View in Genome Browser
HaemAtlas Expression Table for EIF4G1:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for EIF4G1:The EIF4G1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| EIF4G1 | G3BP1 | MINT, IntAct, BioGRID | empirical | 18005740 19615732 |
| EIF4G1 | HNRNPR | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | GABARAPL2 | IntAct, BioGRID | empirical | 17353931 |
| EIF4G1 | DKC1 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | EIF4A1 | HPRD, MINT, IntAct, MIPS, BioGRID, Reactome | empirical | 11408474 9372926 19153607 16932749 16541103 17353931 19203580 9418880 16648488 17289916 11283721 16284618 15475613 14749774 17595167 18625844 14583602 16141059 17245413 19239894 |
| EIF4G1 | EIF4A2 | HPRD, MINT, IntAct, BioGRID, Reactome | empirical | 11408474 17353931 17289916 11283721 16284618 15475613 14749774 17595167 18625844 14583602 16141059 17245413 19239894 |
| EIF4G1 | EIF4B | Reactome | predicted | 11283721 16284618 15475613 14749774 17595167 18625844 14583602 16141059 17245413 19239894 |
| EIF4G1 | EIF4E | HPRD, MINT, IntAct, MIPS, BioGRID, Reactome, Sanger Interaction Map | empirical | 10600798 16648488 9372926 16281055 16541103 12071973 7651417 15361857 15153109 9418880 10753870 12149653 16010989 16236269 16720573 17289916 11283721 16284618 15475613 14749774 17595167 18625844 14583602 16141059 17245413 19239894 8449919 15345047 |
| EIF4G1 | EIF4G1 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | EIF5 | HPRD | empirical | 11331597 |
| EIF4G1 | EPB41 | IntAct | empirical | 17353931 |
| EIF4G1 | ESR1 | IntAct | empirical | 21182205 |
| EIF4G1 | NCBP2 | HPRD, IntAct, Sanger Interaction Map | empirical | 15361857 15345047 |
| EIF4G1 | RRP12 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | ZC3H7B | IntAct | empirical | 15047801 |
| EIF4G1 | SMG6 | Reactome | predicted | 19060897 18974281 17053788 |
| EIF4G1 | SMG5 | Reactome | predicted | 19060897 18974281 17053788 |
| EIF4G1 | UPF2 | HPRD, IntAct | empirical | 15361857 |
| EIF4G1 | PABPC1 | HPRD, MINT, IntAct, BioGRID, Reactome | empirical | 9857202 12086624 11283721 16284618 15475613 14749774 17595167 18625844 14583602 16141059 17245413 19239894 18573886 16556936 12819195 10205060 19060897 18974281 17053788 |
| EIF4G1 | GK | IntAct | empirical | 21988832 |
| EIF4G1 | PDCD4 | HPRD, IntAct, BioGRID | empirical | 12054647 |
| EIF4G1 | MKNK2 | BioGRID | empirical | 12897141 |
| EIF4G1 | ANXA5 | HPRD, MINT, IntAct | empirical | 16169070 |
| EIF4G1 | EIF4E3 | Reactome | predicted | 17289916 |
| EIF4G1 | HNRNPD | IntAct, BioGRID | empirical | 16556936 18573886 10205060 |
| EIF4G1 | HSPA1B | Reactome | predicted | 18573886 16556936 12819195 10205060 |
| EIF4G1 | HSPA8 | Reactome | predicted | 18573886 16556936 12819195 10205060 |
| EIF4G1 | HSPB1 | HPRD, MINT, Reactome | empirical | 10859165 18573886 16556936 12819195 10205060 |
| EIF4G1 | ARF6 | IntAct | empirical | 17353931 |
| EIF4G1 | MAGEA6 | IntAct, BioGRID | empirical | 17353931 |
| EIF4G1 | MCC | IntAct | empirical | 17353931 |
| EIF4G1 | NCBP1 | HPRD, IntAct, BioGRID | empirical | 11340157 15361857 |
| EIF4G1 | PAK2 | HPRD, IntAct | empirical | 16281055 17353931 |
| EIF4G1 | TH1L | BioGRID | empirical | 17353931 |
| EIF4G1 | POLE | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | RBM28 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | PRKAB1 | IntAct | empirical | 17353931 |
| EIF4G1 | LUC7L | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | UPF1 | Reactome | predicted | 19060897 18974281 17053788 |
| EIF4G1 | NOL6 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | UPF3B | IntAct | empirical | 15361857 |
| EIF4G1 | SNRNP70 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | SNRPD2 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | SNRPD3 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | SSB | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | TRAF6 | IntAct | empirical | 17353931 |
| EIF4G1 | UBC | BioGRID | empirical | 22108332 21139048 21890473 21906983 |
| EIF4G1 | YWHAZ | MINT | empirical | 15161933 |
| EIF4G1 | MLF1IP | BioGRID | empirical | 21900206 |
| EIF4G1 | MKNK1 | HPRD, MINT, IntAct, BioGRID | empirical | 9878069 15234964 |
| EIF4G1 | EIF3A | HPRD, MINT, IntAct, BioGRID | empirical | 16541103 20360068 |
| EIF4G1 | EIF3B | HPRD, MINT, BioGRID | empirical | 16541103 |
| EIF4G1 | EIF3F | BioGRID | empirical | 19615732 |
| EIF4G1 | EIF3H | IntAct, BioGRID | empirical | 19615732 |
| EIF4G1 | EIF3I | HPRD, MINT, BioGRID | empirical | 16541103 |
| EIF4G1 | EIF3J | MINT | empirical | 16932749 |
| EIF4G1 | EIF4G3 | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | USP10 | IntAct, BioGRID | empirical | 19615732 |
| EIF4G1 | ZFYVE9 | HPRD, MINT | empirical | 15231748 |
| EIF4G1 | EIF4E2 | IntAct | empirical | 15153109 |
| EIF4G1 | IKBKE | IntAct | empirical | 17353931 |
| EIF4G1 | EIF5B | Sanger Interaction Map | predicted | 15345047 |
| EIF4G1 | KIAA0101 | BioGRID | empirical | 21628590 |
| EIF4G1 | EIF4A3 | IntAct, Reactome | empirical | 15361857 17289916 11283721 16284618 15475613 14749774 17595167 18625844 14583602 16141059 17245413 19239894 |
| EIF4G1 | SMG7 | Reactome | predicted | 19060897 18974281 17053788 |
| EIF4G1 | USP3 | IntAct, BioGRID | empirical | 19615732 |
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Publications: 175
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Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death.
Vosler PS, Gao Y, Brennan CS, Yanagiya A, Gan Y, Cao G, Zhang F, Morley SJ, Sonenberg N, Bennett MV, Chen J
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22006312
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Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: comparison with eIF4E-binding protein.
Umenaga Y, Paku KS, In Y, Ishida T, Tomoo K
Biochem Biophys Res Commun. 2011
PubMed ID: 21964297
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Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B.
Özeş AR, Feoktistova K, Avanzino BC, Fraser CS
J Mol Biol. 2011
PubMed ID: 21840318
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Translation initiator EIF4G1 mutations in familial Parkinson disease.
Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling BH, Bacon JA, Hentati E, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ, Zubair AC, Uitti RJ, Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA, Hentati F, Dickson DW, Destée A, Farrer MJ
Am J Hum Genet. 2011
PubMed ID: 21907011
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Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.
Chiluiza D, Bargo S, Callahan R, Rhoads RE
J Biol Chem. 2011
PubMed ID: 21737453
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A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
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Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics.
Jia H, Liu C, Ge F, Xiao C, Lu C, Wang T, He Q
Biomed Environ Sci. 2011
PubMed ID: 22108332
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Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
Dobrikov M, Dobrikova E, Shveygert M, Gromeier M
Mol Cell Biol. 2011
PubMed ID: 21576361
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Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor.
Waters LC, Strong SL, Ferlemann E, Oka O, Muskett FW, Veverka V, Banerjee S, Schmedt T, Henry AJ, Klempnauer KH, Carr MD
J Biol Chem. 2011
PubMed ID: 21454508
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Functional impairment of eIF4A and eIF4G factors correlates with inhibition of influenza virus mRNA translation.
Yángüez E, Castello A, Welnowska E, Carrasco L, Goodfellow I, Nieto A
Virology. 2011
PubMed ID: 21377182
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Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.
Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21289279
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection.
Sukarieh R, Sonenberg N, Pelletier J
J Gen Virol. 2010
PubMed ID: 20053821
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Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
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NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome.
Alard A, Fabre B, Anesia R, Marboeuf C, Pierre P, Susini C, Bousquet C, Pyronnet S
Mol Cell Biol. 2010
PubMed ID: 20028737
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Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma.
Tu L, Liu Z, He X, He Y, Yang H, Jiang Q, Xie S, Xiao G, Li X, Yao K, Fang W
Mol Cancer. 2010
PubMed ID: 20398343
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The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G.
Suzuki Y, Minami M, Suzuki M, Abe K, Zenno S, Tsujimoto M, Matsumoto K, Minami Y
J Biol Chem. 2009
PubMed ID: 19850929
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Translation of mRNAs from vesicular stomatitis virus and vaccinia virus is differentially blocked in cells with depletion of eIF4GI and/or eIF4GII.
Welnowska E, Castelló A, Moral P, Carrasco L
J Mol Biol. 2009
PubMed ID: 19769989
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Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
Matafora V, D'Amato A, Mori S, Blasi F, Bachi A
Mol Cell Proteomics. 2009
PubMed ID: 19596686
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A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation.
Kim KM, Cho H, Choi K, Kim J, Kim BW, Ko YG, Jang SK, Kim YK
Genes Dev. 2009
PubMed ID: 19648179
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Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).
Osman AM, van Kol S, Peijnenburg A, Blokland M, Pennings JL, Kleinjans JC, van Loveren H
J Immunotoxicol. 2009
PubMed ID: 19552622
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
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Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
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Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer.
Silvera D, Arju R, Darvishian F, Levine PH, Zolfaghari L, Goldberg J, Hochman T, Formenti SC, Schneider RJ
Nat Cell Biol. 2009
PubMed ID: 19525934
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Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
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Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
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Global and gene-specific translational regulation in rat lung development.
Otulakowski G, Duan W, O'Brodovich H
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18952566
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Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.
Yanagiya A, Svitkin YV, Shibata S, Mikami S, Imataka H, Sonenberg N
Mol Cell Biol. 2009
PubMed ID: 19114555
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Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.
Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G
Cell. 2009
PubMed ID: 19203580
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HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage.
Castelló A, Franco D, Moral-López P, Berlanga JJ, Alvarez E, Wimmer E, Carrasco L
PLoS One. 2009
PubMed ID: 19956697
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Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
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The phagosomal proteome in interferon-gamma-activated macrophages.
Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
Immunity. 2009
PubMed ID: 19144319
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Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
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Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.
Harb M, Becker MM, Vitour D, Baron CH, Vende P, Brown SC, Bolte S, Arold ST, Poncet D
J Virol. 2008
PubMed ID: 18799579
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex.
Slepenkov SV, Korneeva NL, Rhoads RE
J Biol Chem. 2008
PubMed ID: 18614538
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Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.
Zhou H, Ye M, Dong J, Han G, Jiang X, Wu R, Zou H
J Proteome Res. 2008
PubMed ID: 18630941
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Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay.
Sinsimer KS, Gratacós FM, Knapinska AM, Lu J, Krause CD, Wierzbowski AV, Maher LR, Scrudato S, Rivera YM, Gupta S, Turrin DK, De La Cruz MP, Pestka S, Brewer G
Mol Cell Biol. 2008
PubMed ID: 18573886
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Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
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A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
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c-Myc and eIF4F are components of a feedforward loop that links transcription and translation.
Lin CJ, Cencic R, Mills JR, Robert F, Pelletier J
Cancer Res. 2008
PubMed ID: 18593934
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Neural RNA-binding protein Musashi1 inhibits translation initiation by competing with eIF4G for PABP.
Kawahara H, Imai T, Imataka H, Tsujimoto M, Matsumoto K, Okano H
J Cell Biol. 2008
PubMed ID: 18490513
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eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.
Ramírez-Valle F, Braunstein S, Zavadil J, Formenti SC, Schneider RJ
J Cell Biol. 2008
PubMed ID: 18426977
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Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells.
Walsh D, Arias C, Perez C, Halladin D, Escandon M, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Mohr I
Mol Cell Biol. 2008
PubMed ID: 18250159
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PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains.
Suzuki C, Garces RG, Edmonds KA, Hiller S, Hyberts SG, Marintchev A, Wagner G
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18296639
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Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
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SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.
Cakmakci NG, Lerner RS, Wagner EJ, Zheng L, Marzluff WF
Mol Cell Biol. 2008
PubMed ID: 18025107
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Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.
Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y
Anal Sci. 2008
PubMed ID: 18187866
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Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
J Proteome Res. 2007
PubMed ID: 17924679
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Steroid and oxygen effects on eIF4F complex, mTOR, and ENaC translation in fetal lung epithelia.
Otulakowski G, Duan W, Gandhi S, O'brodovich H
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17556672
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EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
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Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.
Peffley DM, Sharma C, Hentosh P, Buechler RD
Arch Biochem Biophys. 2007
PubMed ID: 17601486
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Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung.
Comtesse N, Keller A, Diesinger I, Bauer C, Kayser K, Huwer H, Lenhof HP, Meese E
Int J Cancer. 2007
PubMed ID: 17290396
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Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1.
Chau DH, Yuan J, Zhang H, Cheung P, Lim T, Liu Z, Sall A, Yang D
Apoptosis. 2007
PubMed ID: 17195095
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Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53.
Constantinou C, Clemens MJ
Cell Death Differ. 2007
PubMed ID: 16990847
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Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17287340
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Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.
Lin JC, Hsu M, Tarn WY
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17284590
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Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
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Functional analysis of individual binding activities of the scaffold protein eIF4G.
Hinton TM, Coldwell MJ, Carpenter GA, Morley SJ, Pain VM
J Biol Chem. 2007
PubMed ID: 17130132
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The full-ORF clone resource of the German cDNA Consortium.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC Genomics. 2007
PubMed ID: 17974005
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Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
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Structural basis for inhibition of translation by the tumor suppressor Pdcd4.
LaRonde-LeBlanc N, Santhanam AN, Baker AR, Wlodawer A, Colburn NH
Mol Cell Biol. 2007
PubMed ID: 17060447
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Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis.
Vary TC, Deiter G, Lang CH
Shock. 2006
PubMed ID: 17117141
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
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Specific isoforms of translation initiation factor 4GI show differences in translational activity.
Coldwell MJ, Morley SJ
Mol Cell Biol. 2006
PubMed ID: 16982693
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The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
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A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
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Translation initiation factor eIF4G-1 binds to eIF3 through the eIF3e subunit.
LeFebvre AK, Korneeva NL, Trutschl M, Cvek U, Duzan RD, Bradley CA, Hershey JW, Rhoads RE
J Biol Chem. 2006
PubMed ID: 16766523
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Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E.
Murata T, Shimotohno K
J Biol Chem. 2006
PubMed ID: 16720573
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Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.
Bellsolell L, Cho-Park PF, Poulin F, Sonenberg N, Burley SK
Structure. 2006
PubMed ID: 16698552
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Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells.
Connolly E, Braunstein S, Formenti S, Schneider RJ
Mol Cell Biol. 2006
PubMed ID: 16648488
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Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay.
Lu JY, Bergman N, Sadri N, Schneider RJ
RNA. 2006
PubMed ID: 16556936
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The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
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mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin.
Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC
EMBO J. 2006
PubMed ID: 16541103
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Age-associated decrease in contraction-induced activation of downstream targets of Akt/mTor signaling in skeletal muscle.
Funai K, Parkington JD, Carambula S, Fielding RA
Am J Physiol Regul Integr Comp Physiol. 2006
PubMed ID: 16306159
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Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.
Okazaki Y, Suzuki A, Sawada T, Ohtake-Yamanaka M, Inoue T, Hasebe T, Yamada R, Yamamoto K
Biochem Biophys Res Commun. 2006
PubMed ID: 16412378
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Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.
Yang R, Weber DJ, Carrier F
Nucleic Acids Res. 2006
PubMed ID: 16513844
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2.
Ling J, Morley SJ, Traugh JA
EMBO J. 2005
PubMed ID: 16281055
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Effect of leptin on liver alcohol dehydrogenase.
Mezey E, Rennie-Tankersley L, Potter JJ
Biochem Biophys Res Commun. 2005
PubMed ID: 16236269
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A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
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eIF4G and CBP80 share a common origin and similar domain organization: implications for the structure and function of eIF4G.
Marintchev A, Wagner G
Biochemistry. 2005
PubMed ID: 16156639
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism.
Greenberg VL, Zimmer SG
Oncogene. 2005
PubMed ID: 15897904
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Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.
Constantinou C, Clemens MJ
Oncogene. 2005
PubMed ID: 15897901
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Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.
Gorrini C, Loreni F, Gandin V, Sala LA, Sonenberg N, Marchisio PC, Biffo S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15961545
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Translation of eukaryotic translation initiation factor 4GI (eIF4GI) proceeds from multiple mRNAs containing a novel cap-dependent internal ribosome entry site (IRES) that is active during poliovirus infection.
Byrd MP, Zamora M, Lloyd RE
J Biol Chem. 2005
PubMed ID: 15755734
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The binding of foot-and-mouth disease virus leader proteinase to eIF4GI involves conserved ionic interactions.
Foeger N, Kuehnel E, Cencic R, Skern T
FEBS J. 2005
PubMed ID: 15885108
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IGF-I activates the eIF4F system in cardiac muscle in vivo.
Vary TC, Lang CH
Mol Cell Biochem. 2005
PubMed ID: 16010989
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Embryonic poly(A)-binding protein stimulates translation in germ cells.
Wilkie GS, Gautier P, Lawson D, Gray NK
Mol Cell Biol. 2005
PubMed ID: 15713657
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Tagging genes with cassette-exchange sites.
Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R
Nucleic Acids Res. 2005
PubMed ID: 15741177
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Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
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Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling.
Vary TC, Deiter G, Goodman SA
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15388509
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase.
Kudchodkar SB, Yu Y, Maguire TG, Alwine JC
J Virol. 2004
PubMed ID: 15452223
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Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site.
Strong R, Belsham GJ
J Gen Virol. 2004
PubMed ID: 15448358
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eIF4G is required for the pioneer round of translation in mammalian cells.
Lejeune F, Ranganathan AC, Maquat LE
Nat Struct Mol Biol. 2004
PubMed ID: 15361857
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Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Korneeva NL, Rhoads RE, Sonenberg N, Traugh JA
J Biol Chem. 2004
PubMed ID: 15234964
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Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
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Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting.
Xi Q, Cuesta R, Schneider RJ
Genes Dev. 2004
PubMed ID: 15314025
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Upstream and downstream of mTOR.
Hay N, Sonenberg N
Genes Dev. 2004
PubMed ID: 15314020
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Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
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Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.
Cuesta R, Xi Q, Schneider RJ
J Virol. 2004
PubMed ID: 15220445
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Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.
Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, Manivel JC, Sonenberg N, Yee D, Bitterman PB, Polunovsky VA
Cancer Cell. 2004
PubMed ID: 15193258
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Characterization of mammalian eIF4E-family members.
Joshi B, Cameron A, Jagus R
Eur J Biochem. 2004
PubMed ID: 15153109
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Expression of fragments of translation initiation factor eIF4GI reveals a nuclear localisation signal within the N-terminal apoptotic cleavage fragment N-FAG.
Coldwell MJ, Hashemzadeh-Bonehi L, Hinton TM, Morley SJ, Pain VM
J Cell Sci. 2004
PubMed ID: 15128869
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
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RoXaN, a novel cellular protein containing TPR, LD, and zinc finger motifs, forms a ternary complex with eukaryotic initiation factor 4G and rotavirus NSP3.
Vitour D, Lindenbaum P, Vende P, Becker MM, Poncet D
J Virol. 2004
PubMed ID: 15047801
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Two zebrafish eIF4E family members are differentially expressed and functionally divergent.
Robalino J, Joshi B, Fahrenkrug SC, Jagus R
J Biol Chem. 2004
PubMed ID: 14701818
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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The eukaryotic translation initiation factor 4GI is cleaved by different retroviral proteases.
Alvarez E, Menéndez-Arias L, Carrasco L
J Virol. 2003
PubMed ID: 14610163
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved.
Thompson SR, Sarnow P
Virology. 2003
PubMed ID: 14592777
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
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The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG
Mol Cell Biol. 2003
PubMed ID: 12897141
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Characterization of a novel RNA-binding region of eIF4GI critical for ribosomal scanning.
Prévôt D, Décimo D, Herbreteau CH, Roux F, Garin J, Darlix JL, Ohlmann T
EMBO J. 2003
PubMed ID: 12682023
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Overproduction of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organization of microtubules.
Hashemzadeh-Bonehi L, Curtis PS, Morley SJ, Thorpe JR, Pain VM
Genes Cells. 2003
PubMed ID: 12581158
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Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.
Kimball SR, Horetsky RL, Ron D, Jefferson LS, Harding HP
Am J Physiol Cell Physiol. 2003
PubMed ID: 12388085
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Cleavage of eIF4G by HIV-1 protease: effects on translation.
Perales C, Carrasco L, Ventoso I
FEBS Lett. 2003
PubMed ID: 12505164
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1.
Connor JH, Lyles DS
J Virol. 2002
PubMed ID: 12239292
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p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation.
Horton LE, Bushell M, Barth-Baus D, Tilleray VJ, Clemens MJ, Hensold JO
Oncogene. 2002
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Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons.
Byrd MP, Zamora M, Lloyd RE
Mol Cell Biol. 2002
PubMed ID: 12052860
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Recognition of eIF4G by rotavirus NSP3 reveals a basis for mRNA circularization.
Groft CM, Burley SK
Mol Cell. 2002
PubMed ID: 12086624
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Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors.
Patel J, McLeod LE, Vries RG, Flynn A, Wang X, Proud CG
Eur J Biochem. 2002
PubMed ID: 12071973
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Up-regulation of PDCD4 in senescent human diploid fibroblasts.
Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY
Biochem Biophys Res Commun. 2002
PubMed ID: 12054647
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In vitro cleavage of eIF4GI but not eIF4GII by HIV-1 protease and its effects on translation in the rabbit reticulocyte lysate system.
Ohlmann T, Prévôt D, Décimo D, Roux F, Garin J, Morley SJ, Darlix JL
J Mol Biol. 2002
PubMed ID: 12054764
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Mass spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms.
Bradley CA, Padovan JC, Thompson TL, Benoit CA, Chait BT, Rhoads RE
J Biol Chem. 2002
PubMed ID: 11821405
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Inhibition of translation and progesterone-induced maturation of Xenopus oocytes by expressing the amino-terminal portion of the eukaryotic translation initiation factor 4G.
Wakiyama M, Miura K
Biosci Biotechnol Biochem. 2002
PubMed ID: 11866104
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HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation.
Ventoso I, Blanco R, Perales C, Carrasco L
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11606767
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Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo.
Li W, Belsham GJ, Proud CG
J Biol Chem. 2001
PubMed ID: 11408474
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Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m(7) guanosine cap.
McKendrick L, Thompson E, Ferreira J, Morley SJ, Lewis JD
Mol Cell Biol. 2001
PubMed ID: 11340157
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Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.
Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, Donahue TF, Hinnebusch AG
EMBO J. 2001
PubMed ID: 11331597
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The sequence of the human genome.
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Science. 2001
PubMed ID: 11181995
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
Scheper GC, Morrice NA, Kleijn M, Proud CG
Mol Cell Biol. 2001
PubMed ID: 11154262
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation.
Wakiyama M, Imataka H, Sonenberg N
Curr Biol. 2000
PubMed ID: 10996799
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Extremely efficient cleavage of eIF4G by picornaviral proteinases L and 2A in vitro.
Glaser W, Skern T
FEBS Lett. 2000
PubMed ID: 11034318
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Multiple portions of poly(A)-binding protein stimulate translation in vivo.
Gray NK, Coller JM, Dickson KS, Wickens M
EMBO J. 2000
PubMed ID: 10970864
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
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Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F.
Cuesta R, Xi Q, Schneider RJ
EMBO J. 2000
PubMed ID: 10880459
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Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes.
Cuesta R, Laroia G, Schneider RJ
Genes Dev. 2000
PubMed ID: 10859165
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Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase.
Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S
J Biol Chem. 2000
PubMed ID: 10753870
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Amino acid-induced stimulation of translation initiation in rat skeletal muscle.
Vary TC, Jefferson LS, Kimball SR
Am J Physiol. 1999
PubMed ID: 10600798
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Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII.
Li Q, Imataka H, Morino S, Rogers GW, Richter-Cook NJ, Merrick WC, Sonenberg N
Mol Cell Biol. 1999
PubMed ID: 10523622
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Control of mRNA decay by heat shock-ubiquitin-proteasome pathway.
Laroia G, Cuesta R, Brewer G, Schneider RJ
Science. 1999
PubMed ID: 10205060
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Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.
Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA
Mol Cell Biol. 1999
PubMed ID: 10022874
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Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.
Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N
EMBO J. 1999
PubMed ID: 9878069
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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Gingras AC, Raught B, Sonenberg N
Annu Rev Biochem. 1999
PubMed ID: 10872469
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.
Imataka H, Gradi A, Sonenberg N
EMBO J. 1998
PubMed ID: 9857202
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Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F.
Piron M, Vende P, Cohen J, Poncet D
EMBO J. 1998
PubMed ID: 9755181
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Poliovirus 2A proteinase cleaves directly the eIF-4G subunit of eIF-4F complex.
Ventoso I, MacMillan SE, Hershey JW, Carrasco L
FEBS Lett. 1998
PubMed ID: 9755863
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A novel functional human eukaryotic translation initiation factor 4G.
Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N
Mol Cell Biol. 1998
PubMed ID: 9418880
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Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A.
Imataka H, Sonenberg N
Mol Cell Biol. 1997
PubMed ID: 9372926
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Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro.
Eberle J, Krasagakis K, Orfanos CE
Int J Cancer. 1997
PubMed ID: 9139875
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Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma.
Brass N, Heckel D, Sahin U, Pfreundschuh M, Sybrecht GW, Meese E
Hum Mol Genet. 1997
PubMed ID: 9002667
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A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases.
Lamphear BJ, Rhoads RE
Biochemistry. 1996
PubMed ID: 8961935
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
Haghighat A, Mader S, Pause A, Sonenberg N
EMBO J. 1995
PubMed ID: 8521827
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The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins.
Mader S, Lee H, Pause A, Sonenberg N
Mol Cell Biol. 1995
PubMed ID: 7651417
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Human protein synthesis initiation factor eIF-4 gamma is encoded by a single gene (EIF4G) that maps to chromosome 3q27-qter.
Yan R, Rhoads RE
Genomics. 1995
PubMed ID: 7601469
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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.
Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N
Nature. 1994
PubMed ID: 7935836
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Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.
Lamphear BJ, Yan R, Yang F, Waters D, Liebig HD, Klump H, Kuechler E, Skern T, Rhoads RE
J Biol Chem. 1993
PubMed ID: 8396129
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The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.
Yoder-Hill J, Pause A, Sonenberg N, Merrick WC
J Biol Chem. 1993
PubMed ID: 8449919
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Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma.
Yan R, Rychlik W, Etchison D, Rhoads RE
J Biol Chem. 1992
PubMed ID: 1429670
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