Home AHCY
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Regions Overlapping this Feature:
Mouse: 1
Rat: 2
Linkage Regions: 1 Available
Other Regions: 2 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd13 | Mouse | chr2:114118625..158330390 | 44.21 | 582 | 3 no lod score |
Other Regions: 2 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm27 | Rat | chr3:96506745..149496698 | 52.99 | 606 |
| Iddm13 | Rat | chr3:131188558..163778754 | 32.59 | 406 |
(Human) GRCh37 - chr20:32868071..32899608 (31.54 kb) View in Genome Browser
(Mouse) NCBIM37 - chr2:154885046..154900233 (15.19 kb) View in Genome Browser
(Rat) RGSC3.4 - chr3:145544834..145560058 (15.22 kb) View in Genome Browser
HaemAtlas Expression Table for AHCY:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for AHCY:The AHCY interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| AHCY | HDAC5 | BioGRID | empirical | 21081666 |
| AHCY | EIF1B | IntAct | empirical | 17353931 |
| AHCY | BCKDK | Sanger Interaction Map | predicted | 15345047 |
| AHCY | KIF1C | IntAct, BioGRID | empirical | 20360068 |
| AHCY | YWHAQ | BioGRID | empirical | 15161933 |
| AHCY | GABARAP | IntAct | empirical | 20562859 |
| AHCY | AHCY | HPRD | empirical | 10933798 |
| AHCY | GABARAPL1 | IntAct | empirical | 20562859 |
| AHCY | TRAF3IP1 | IntAct | empirical | 20391533 |
| AHCY | HLA-B | IntAct, BioGRID | empirical | 17353931 |
| AHCY | MCC | IntAct | empirical | 17353931 |
| AHCY | PAK2 | IntAct | empirical | 17353931 |
| AHCY | PINX1 | IntAct, BioGRID | empirical | 17353931 |
| AHCY | MAPK13 | IntAct, BioGRID | empirical | 19135240 |
| AHCY | PXN | IntAct | empirical | 21988832 |
| AHCY | OSGEPL1 | Sanger Interaction Map | predicted | 15345047 |
| AHCY | SLC2A4 | IntAct | empirical | 16396496 |
| AHCY | TP73 | BioGRID | empirical | 20308539 |
| AHCY | TRAF1 | IntAct | empirical | 15102471 |
| AHCY | TRAF6 | IntAct | empirical | 17353931 |
| AHCY | UBC | BioGRID | empirical | 16196087 18781797 21987572 21963094 21139048 21890473 21906983 |
| AHCY | YWHAZ | MINT | empirical | 15161933 |
| AHCY | MAP1LC3B | IntAct | empirical | 20562859 |
| AHCY | BCAR3 | IntAct | empirical | 17353931 |
| AHCY | MAP1LC3A | IntAct | empirical | 20562859 |
| AHCY | KIAA0101 | BioGRID | empirical | 21628590 |
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Type 1 Diabetes Publications: 1
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Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R
Cell. 2009
PubMed ID: 19135240
Publications: 107
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Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
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Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
Tryndyak VP, Han T, Muskhelishvili L, Fuscoe JC, Ross SA, Beland FA, Pogribny IP
Mol Nutr Food Res. 2011
PubMed ID: 20938992
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Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
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Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes.
Grubbs R, Vugrek O, Deisch J, Wagner C, Stabler S, Allen R, Barić I, Rados M, Mudd SH
J Inherit Metab Dis. 2010
PubMed ID: 20852937
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism.
Giusti B, Saracini C, Bolli P, Magi A, Martinelli I, Peyvandi F, Rasura M, Volpe M, Lotta LA, Rubattu S, Mannucci PM, Abbate R
Thromb Haemost. 2010
PubMed ID: 20458436
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A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
Levine AJ, Figueiredo JC, Lee W, Conti DV, Kennedy K, Duggan DJ, Poynter JN, Campbell PT, Newcomb P, Martinez ME, Hopper JL, Le Marchand L, Baron JA, Limburg PJ, Ulrich CM, Haile RW
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20615890
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Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
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Contribution of adenosine related genes to the risk of depression with disturbed sleep.
Gass N, Ollila HM, Utge S, Partonen T, Kronholm E, Pirkola S, Suhonen J, Silander K, Porkka-Heiskanen T, Paunio T
J Affect Disord. 2010
PubMed ID: 20392501
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A genome-scale protein interaction profile of Drosophila p53 uncovers additional nodes of the human p53 network.
Lunardi A, Di Minin G, Provero P, Dal Ferro M, Carotti M, Del Sal G, Collavin L
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20308539
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Crystallization of mouse S-adenosyl-L-homocysteine hydrolase.
Ishihara M, Kusakabe Y, Ohsumichi T, Tanaka N, Nakanishi M, Kitade Y, Nakamura KT
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010
PubMed ID: 20208169
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Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
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S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA cap methylation, protein synthesis, and cell proliferation.
Fernandez-Sanchez ME, Gonatopoulos-Pournatzis T, Preston G, Lawlor MA, Cowling VH
Mol Cell Biol. 2009
PubMed ID: 19805518
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida.
Martinez CA, Northrup H, Lin JI, Morrison AC, Fletcher JM, Tyerman GH, Au KS
Am J Obstet Gynecol. 2009
PubMed ID: 19683694
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Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization.
Feng Q, Keshtgarpour M, Pelleymounter LL, Moon I, Kalari KR, Eckloff BW, Wieben ED, Weinshilboum RM
J Neurochem. 2009
PubMed ID: 19619139
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Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice.
Pawlowski TL, Heringer-Walther S, Cheng CH, Archie JG, Chen CF, Walther T, Srivastava AK
Genomics. 2009
PubMed ID: 19501643
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Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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S-adenosylhomocysteine hydrolase (AHCY) deficiency: two novel mutations with lethal outcome.
Vugrek O, Beluzić R, Nakić N, Mudd SH
Hum Mutat. 2009
PubMed ID: 19177456
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An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).
Franke B, Vermeulen SH, Steegers-Theunissen RP, Coenen MJ, Schijvenaars MM, Scheffer H, den Heijer M, Blom HJ
Birth Defects Res A Clin Mol Teratol. 2009
PubMed ID: 19161160
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Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.
Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19158324
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Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.
Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, Jugessur A, Trung TN, Gjessing HK, Vollset SE, Murray JC, Christensen K, Lie RT
Genet Epidemiol. 2008
PubMed ID: 19048631
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S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.
Leal JF, Ferrer I, Blanco-Aparicio C, Hernández-Losa J, Ramón Y Cajal S, Carnero A, Lleonart ME
Carcinogenesis. 2008
PubMed ID: 18713839
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
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Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
Vieira AR, McHenry TG, Daack-Hirsch S, Murray JC, Marazita ML
Genet Med. 2008
PubMed ID: 18978678
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Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura.
Tao J, Yang M, Chen Z, Huang Y, Zhao Q, Xu J, Ren H, Zhao H, Chen Z, Ren Q, Yang R
J Clin Immunol. 2008
PubMed ID: 18683034
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Streptococcal pyrogenic exotoxin B cleaves human S-adenosylhomocysteine hydrolase and induces hypermethioninemia.
Hsu JF, Chuang WJ, Shiesh SC, Lin YS, Liu CC, Wang CC, Fu TF, Tsai JH, Tsai WL, Huang YJ, Hsieh YH, Wu JJ, Lin MT, Huang W
J Infect Dis. 2008
PubMed ID: 18522500
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Genetic Analysis of 56 Polymorphisms in 17 Genes involved in Methionine Metabolism in patients with Abdonminal Aortic Aneurysm.
Giusti B, Saracini C, Bolli P, Magi A, Sestini I, Sticchi E, Pratesi G, Pulli R, Pratesi C, Abbate R
J Med Genet. 2008
PubMed ID: 18635682
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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability.
Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL
Biochemistry. 2008
PubMed ID: 18393535
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High-Throughput Multiplex Single-Nucleotide Polymorphism (SNP) Analysis in Genes Involved in Methionine Metabolism.
Giusti B, Sestini I, Saracini C, Sticchi E, Bolli P, Magi A, Gori AM, Marcucci R, Gensini GF, Abbate R
Biochem Genet. 2008
PubMed ID: 18427977
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S-Adenosylhomocysteine hydrolase (AdoHcyase) deficiency: enzymatic capabilities of human AdoHcyase are highly effected by changes to codon 89 and its surrounding residues.
Beluzić R, Cuk M, Pavkov T, Barić I, Vugrek O
Biochem Biophys Res Commun. 2008
PubMed ID: 18211827
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S-Adenosylhomocysteine hydrolase overexpression in HEK-293 cells: effect on intracellular adenosine levels, cell viability, and DNA methylation.
Hermes M, Osswald H, Riehle R, Piesch C, Kloor D
Cell Physiol Biochem. 2008
PubMed ID: 18769049
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Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Huang SF, Hwang SF, Chen YM
Hepatology. 2007
PubMed ID: 17937387
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Copper ions inhibit S-adenosylhomocysteine hydrolase by causing dissociation of NAD+ cofactor.
Li M, Li Y, Chen J, Wei W, Pan X, Liu J, Liu Q, Leu W, Zhang L, Yang X, Lu J, Wang K
Biochemistry. 2007
PubMed ID: 17892301
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EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
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Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs.
Yideng J, Jianzhong Z, Ying H, Juan S, Jinge Z, Shenglan W, Xiaoqun H, Shuren W
DNA Cell Biol. 2007
PubMed ID: 17688412
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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 1. Basic features of the association and dissociation processes.
Li QS, Cai S, Borchardt RT, Fang J, Kuczera K, Middaugh CR, Schowen RL
Biochemistry. 2007
PubMed ID: 17447732
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Functional analysis of human S-adenosylhomocysteine hydrolase isoforms SAHH-2 and SAHH-3.
Fumić K, Beluzić R, Cuk M, Pavkov T, Kloor D, Barić I, Mijić I, Vugrek O
Eur J Hum Genet. 2007
PubMed ID: 17164794
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Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells.
Hermes M, Osswald H, Kloor D
Exp Cell Res. 2007
PubMed ID: 17097637
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Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
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Expression and localization of S-adenosylhomocysteine-hydrolase in the rat kidney following carbon monoxide induced hypoxia.
Kloor D, Hermes M, Fink K, Schmid H, Klingel K, Mack A, Grenz A, Osswald H
Cell Physiol Biochem. 2007
PubMed ID: 17310100
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S-adenosylhomocysteine hydrolase is localized at the front of chemotaxing cells, suggesting a role for transmethylation during migration.
Shu S, Mahadeo DC, Liu X, Liu W, Parent CA, Korn ED
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17172447
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Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF
J Proteome Res. 2006
PubMed ID: 17081065
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3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice.
Ovechkin AV, Tyagi N, Sen U, Lominadze D, Steed MM, Moshal KS, Tyagi SC
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16815886
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S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
Buist NR, Glenn B, Vugrek O, Wagner C, Stabler S, Allen RH, Pogribny I, Schulze A, Zeisel SH, Barić I, Mudd SH
J Inherit Metab Dis. 2006
PubMed ID: 16736098
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
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Effect of genetic variation in the human S-adenosylhomocysteine hydrolase gene on total homocysteine concentrations and risk of recurrent venous thrombosis.
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Eur J Hum Genet. 2004
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
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Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Meek SE, Lane WS, Piwnica-Worms H
J Biol Chem. 2004
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S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
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Proc Natl Acad Sci U S A. 2004
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Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
PubMed ID: 14702039
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions.
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Biochemistry. 2003
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
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Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function.
Chen YF, Li PL, Zou AP
Circulation. 2002
PubMed ID: 12208805
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Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice.
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J Biol Chem. 2002
PubMed ID: 12023972
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Contributions of active site residues to the partial and overall catalytic activities of human S-adenosylhomocysteine hydrolase.
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Biochemistry. 2002
PubMed ID: 12069606
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Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
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J Biol Chem. 2002
PubMed ID: 11927587
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Interaction of S-adenosylhomocysteine hydrolase of Xenopus laevis with mRNA(guanine-7-)methyltransferase: implication on its nuclear compartmentalisation and on cap methylation of hnRNA.
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Biochim Biophys Acta. 2002
PubMed ID: 12063172
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Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
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The DNA sequence and comparative analysis of human chromosome 20.
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Nature. 2001
PubMed ID: 11780052
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Targeting "hydrolytic" activity of the S-adenosyl-L-homocysteine hydrolase.
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Nature. 2001
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S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis.
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J Pharmacol Exp Ther. 2001
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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