DDB1

Summary Top Help

Gene Description:

damage specific DNA binding protein 1; damage-specific DNA binding protein 1, 127kDa

Synonyms:

DDB1, XPE, p127-Ddb1, XAP1, DDBA, Ddb1, XPE-BF, 127kDa, AA408517, XPCE, UV-DDB1

Orthologs:

Human DDB1 (protein-coding), Mouse Ddb1 (protein-coding), Rat Ddb1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm25	Rat	chr1:193831373..230411453	36.58	585

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:61066919..61110068 (43.15 kb) View in Genome Browser

(Mouse) NCBIM37 - chr19:10680058..10704312 (24.25 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:213095187..213120986 (25.80 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for DDB1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for DDB1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: None available

Reactome: 5

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 17

Publications from PubMed Top Help

Publications: 153

The stability of histone acetyltransferase general control non-derepressible (Gcn) 5 is regulated by Cullin4-RING E3 ubiquitin ligase.
Li Y, Jaramillo-Lambert A, Hao J, Yang Y, Zhu W
J Biol Chem. 2011
PubMed ID: 21987584
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM
Chem Biol. 2011
PubMed ID: 22118674
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Fischer ES, Scrima A, Böhm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thomä NH
Cell. 2011
PubMed ID: 22118460
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Scrima A, Fischer ES, Lingaraju GM, Böhm K, Cavadini S, Thomä NH
FEBS Lett. 2011
PubMed ID: 21550341
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.
Trilling M, Le VT, Fiedler M, Zimmermann A, Bleifuss E, Hengel H
PLoS Pathog. 2011
PubMed ID: 21698215
PIDD orchestrates translesion DNA synthesis in response to UV irradiation.
Logette E, Schuepbach-Mallepell S, Eckert MJ, Leo XH, Jaccard B, Manzl C, Tardivel A, Villunger A, Quadroni M, Gaide O, Tschopp J
Cell Death Differ. 2011
PubMed ID: 21415862
Damage-specific DNA binding protein 1 (DDB1) is involved in ubiquitin-mediated proteolysis of p27Kip1 in response to UV irradiation.
Iovine B, Iannella ML, Bevilacqua MA
Biochimie. 2011
PubMed ID: 21237244
Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2).
Sung CK, Dahl J, Yim H, Rodig S, Benjamin TL
FASEB J. 2011
PubMed ID: 21228219
Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis.
Jiang L, Rong R, Sheikh MS, Huang Y
J Biol Chem. 2011
PubMed ID: 21205828
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
VprBP binds full-length RAG1 and is required for B-cell development and V(D)J recombination fidelity.
Kassmeier MD, Mondal K, Palmer VL, Raval P, Kumar S, Perry GA, Anderson DK, Ciborowski P, Jackson S, Xiong Y, Swanson PC
EMBO J. 2011
PubMed ID: 22157821
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis.
Yamaji S, Zhang M, Zhang J, Endo Y, Bibikova E, Goff SP, Cang Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21135245
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation.
Ahn J, Vu T, Novince Z, Guerrero-Santoro J, Rapic-Otrin V, Gronenborn AM
J Biol Chem. 2010
PubMed ID: 20870715
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation.
Abbas T, Shibata E, Park J, Jha S, Karnani N, Dutta A
Mol Cell. 2010
PubMed ID: 20932471
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.
Krebs AR, Demmers J, Karmodiya K, Chang NC, Chang AC, Tora L
EMBO Rep. 2010
PubMed ID: 20508642
The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.
Casey L, Wen X, de Noronha CM
Cytokine. 2010
PubMed ID: 20347598
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.
Choi SH, Wright JB, Gerber SA, Cole MD
Genes Dev. 2010
PubMed ID: 20551172
A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.
Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ
Mol Cell. 2010
PubMed ID: 20541997
Damaged DNA-binding protein 1 (DDB1) interacts with Cdh1 and modulates the function of APC/CCdh1.
Lv XB, Xie F, Hu K, Wu Y, Cao LL, Han X, Sang Y, Zeng YX, Kang T
J Biol Chem. 2010
PubMed ID: 20395298
DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA.
Takedachi A, Saijo M, Tanaka K
Mol Cell Biol. 2010
PubMed ID: 20368362
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest.
Belzile JP, Richard J, Rougeau N, Xiao Y, Cohen EA
J Virol. 2010
PubMed ID: 20089662
Identification of a primary target of thalidomide teratogenicity.
Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H
Science. 2010
PubMed ID: 20223979
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.
Giannone RJ, McDonald HW, Hurst GB, Shen RF, Wang Y, Liu Y
PLoS One. 2010
PubMed ID: 20811636
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
CRL4s: the CUL4-RING E3 ubiquitin ligases.
Jackson S, Xiong Y
Trends Biochem Sci. 2009
PubMed ID: 19818632
Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen.
Mullenders J, von der Saal W, van Dongen MM, Reiff U, van Willigen R, Beijersbergen RL, Tiefenthaler G, Klein C, Bernards R
Clin Cancer Res. 2009
PubMed ID: 19723642
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.
Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19651607
REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.
Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG
EMBO Rep. 2009
PubMed ID: 19557001
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.
Maddika S, Chen J
Nat Cell Biol. 2009
PubMed ID: 19287380
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress.
Leung-Pineda V, Huh J, Piwnica-Worms H
Cancer Res. 2009
PubMed ID: 19276361
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation.
Kotake Y, Zeng Y, Xiong Y
Cancer Res. 2009
PubMed ID: 19208841
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN, Wilson KL
PLoS One. 2009
PubMed ID: 19759913
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex.
Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH
Cell. 2008
PubMed ID: 19109893
Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
Alekseev S, Luijsterburg MS, Pines A, Geverts B, Mari PO, Giglia-Mari G, Lans H, Houtsmuller AB, Mullenders LH, Hoeijmakers JH, Vermeulen W
Mol Cell Biol. 2008
PubMed ID: 18936169
A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors.
Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF
Genes Dev. 2008
PubMed ID: 19056892
CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.
Nishitani H, Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T
J Biol Chem. 2008
PubMed ID: 18703516
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A
Genes Dev. 2008
PubMed ID: 18794347
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ
Cell. 2008
PubMed ID: 18775313
Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development.
McCall CM, Miliani de Marval PL, Chastain PD, Jackson SC, He YJ, Kotake Y, Cook JG, Xiong Y
Mol Cell Biol. 2008
PubMed ID: 18606781
Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells.
Chen YR, Liu MT, Chang YT, Wu CC, Hu CY, Chen JY
J Virol. 2008
PubMed ID: 18524825
Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.
Le Rouzic E, Morel M, Ayinde D, Belaïdouni N, Letienne J, Transy C, Margottin-Goguet F
J Biol Chem. 2008
PubMed ID: 18524771
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
Huang J, Chen J
Oncogene. 2008
PubMed ID: 18332868
The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.
Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V
Cancer Res. 2008
PubMed ID: 18593899
Knockdown of damage-specific DNA binding protein 1 (DDB1) enhances the HBx-siRNA-mediated inhibition of HBV replication.
Tang KF, Xie J, Chen M, Liu Q, Zhou XY, Zeng W, Huang AL, Zuo GQ, Wang Y, Xiang R, Ren H
Biologicals. 2008
PubMed ID: 18289873
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y
Genes Dev. 2008
PubMed ID: 18381890
Ribosomal proteins are targets for the NEDD8 pathway.
Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT
EMBO Rep. 2008
PubMed ID: 18274552
mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase.
Ghosh P, Wu M, Zhang H, Sun H
Cell Cycle. 2008
PubMed ID: 18235224
The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1.
Stoyanova T, Yoon T, Kopanja D, Mokyr MB, Raychaudhuri P
Mol Cell Biol. 2008
PubMed ID: 17967871
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.
Höck J, Weinmann L, Ender C, Rüdel S, Kremmer E, Raabe M, Urlaub H, Meister G
EMBO Rep. 2007
PubMed ID: 17932509
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.
Tan L, Ehrlich E, Yu XF
J Virol. 2007
PubMed ID: 17626091
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
Wen X, Duus KM, Friedrich TD, de Noronha CM
J Biol Chem. 2007
PubMed ID: 17620334
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.
Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17609381
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.
Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, Miki H, Takahashi S, Kouzmenko A, Nohara K, Chiba T, Fujii-Kuriyama Y, Kato S
Nature. 2007
PubMed ID: 17392787
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.
Schröfelbauer B, Hakata Y, Landau NR
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360488
DDB1 is essential for genomic stability in developing epidermis.
Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17301228
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.
DeHart JL, Zimmerman ES, Ardon O, Monteiro-Filho CM, Argañaraz ER, Planelles V
Virol J. 2007
PubMed ID: 17559673
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.
Cang Y, Zhang J, Nicholas SA, Bastien J, Li B, Zhou P, Goff SP
Cell. 2006
PubMed ID: 17129780
DNA nucleotide excision repair-dependent signaling to checkpoint activation.
Marini F, Nardo T, Giannattasio M, Minuzzo M, Stefanini M, Plevani P, Muzi Falconi M
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17088560
DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.
He YJ, McCall CM, Hu J, Zeng Y, Xiong Y
Genes Dev. 2006
PubMed ID: 17079684
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H
Nat Cell Biol. 2006
PubMed ID: 17041588
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D
Mol Cell Biol. 2006
PubMed ID: 16940174
Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.
Angers S, Li T, Yi X, MacCoss MJ, Moon RT, Zheng N
Nature. 2006
PubMed ID: 16964240
DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity.
Li J, Wang QE, Zhu Q, El-Mahdy MA, Wani G, Praetorius-Ibba M, Wani AA
Cancer Res. 2006
PubMed ID: 16951172
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.
Jin J, Arias EE, Chen J, Harper JW, Walter JC
Mol Cell. 2006
PubMed ID: 16949367
L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
Higa LA, Banks D, Wu M, Kobayashi R, Sun H, Zhang H
Cell Cycle. 2006
PubMed ID: 16861906
L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes.
Banks D, Wu M, Higa LA, Gavrilova N, Quan J, Ye T, Kobayashi R, Sun H, Zhang H
Cell Cycle. 2006
PubMed ID: 16861890
Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC.
El-Mahdy MA, Zhu Q, Wang QE, Wani G, Praetorius-Ibba M, Wani AA
J Biol Chem. 2006
PubMed ID: 16527807
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.
Wang H, Zhai L, Xu J, Joo HY, Jackson S, Erdjument-Bromage H, Tempst P, Xiong Y, Zhang Y
Mol Cell. 2006
PubMed ID: 16678110
Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome.
Bondar T, Kalinina A, Khair L, Kopanja D, Nag A, Bagchi S, Raychaudhuri P
Mol Cell Biol. 2006
PubMed ID: 16537899
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.
Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A
J Biol Chem. 2006
PubMed ID: 16407252
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Nishitani H, Sugimoto N, Roukos V, Nakanishi Y, Saijo M, Obuse C, Tsurimoto T, Nakayama KI, Nakayama K, Fujita M, Lygerou Z, Nishimoto T
EMBO J. 2006
PubMed ID: 16482215
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapić-Otrin V, Levine AS
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16473935
An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage.
Hu J, Xiong Y
J Biol Chem. 2006
PubMed ID: 16407242
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
Li T, Chen X, Garbutt KC, Zhou P, Zheng N
Cell. 2006
PubMed ID: 16413485
DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA.
Wittschieben BØ, Iwai S, Wood RD
J Biol Chem. 2005
PubMed ID: 16223728
Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.
Kulaksiz G, Reardon JT, Sancar A
Mol Cell Biol. 2005
PubMed ID: 16260596
Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1.
Precious B, Childs K, Fitzpatrick-Swallow V, Goodbourn S, Randall RE
J Virol. 2005
PubMed ID: 16227264
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
CAND1 enhances deneddylation of CUL1 by COP9 signalosome.
Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB
Biochem Biophys Res Commun. 2005
PubMed ID: 16036220
WW domains provide a platform for the assembly of multiprotein networks.
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T
Mol Cell Biol. 2005
PubMed ID: 16055720
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex.
Sugasawa K, Okuda Y, Saijo M, Nishi R, Matsuda N, Chu G, Mori T, Iwai S, Tanaka K, Tanaka K, Hanaoka F
Cell. 2005
PubMed ID: 15882621
DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex.
Matsuda N, Azuma K, Saijo M, Iemura S, Hioki Y, Natsume T, Chiba T, Tanaka K, Tanaka K
DNA Repair (Amst). 2005
PubMed ID: 15811626
Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death.
Leupin O, Bontron S, Schaeffer C, Strubin M
J Virol. 2005
PubMed ID: 15767425
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage.
Hu J, McCall CM, Ohta T, Xiong Y
Nat Cell Biol. 2004
PubMed ID: 15448697
Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Powles N, Babbs C, Ficker M, Schimmang T, Maconochie M
Dev Biol. 2004
PubMed ID: 15031102
Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.
Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM
Science. 2004
PubMed ID: 14739464
Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K
Genes Cells. 2004
PubMed ID: 15009096
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing.
Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN
J Biol Chem. 2003
PubMed ID: 12840015
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities.
Leupin O, Bontron S, Strubin M
J Virol. 2003
PubMed ID: 12743284
The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage.
Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, Kisselev AF, Tanaka K, Nakatani Y
Cell. 2003
PubMed ID: 12732143
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5.
Andrejeva J, Poole E, Young DF, Goodbourn S, Randall RE
J Virol. 2002
PubMed ID: 12388698
Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2.
Bontron S, Lin-Marq N, Strubin M
J Biol Chem. 2002
PubMed ID: 12151405
Interaction between UV-damaged DNA binding activity proteins and the c-Abl tyrosine kinase.
Cong F, Tang J, Hwang BJ, Vuong BQ, Chu G, Goff SP
J Biol Chem. 2002
PubMed ID: 12107171
Identification of rat DDB1, a putative DNA repair protein, and functional correlation with its damaged-DNA recognition activity.
Sun NK, Lu HP, Chao CC
J Biomed Sci. 2002
PubMed ID: 12145536
Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex.
Bergametti F, Sitterlin D, Transy C
J Virol. 2002
PubMed ID: 12050362
Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.
Rapić-Otrin V, McLenigan MP, Bisi DC, Gonzalez M, Levine AS
Nucleic Acids Res. 2002
PubMed ID: 12034848
UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation.
Chen X, Zhang Y, Douglas L, Zhou P
J Biol Chem. 2001
PubMed ID: 11673459
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo.
Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG
Mol Cell Biol. 2001
PubMed ID: 11564863
Hepatitis B virus X protein interferes with cell viability through interaction with the p127-kDa UV-damaged DNA-binding protein.
Lin-Marq N, Bontron S, Leupin O, Strubin M
Virology. 2001
PubMed ID: 11531405
The effects of aging on gene expression in the hypothalamus and cortex of mice.
Jiang CH, Tsien JZ, Schultz PG, Hu Y
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11172053
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Nuclear transport of human DDB protein induced by ultraviolet light.
Liu W, Nichols AF, Graham JA, Dualan R, Abbas A, Linn S
J Biol Chem. 2000
PubMed ID: 10777491
Studies of the murine DDB1 and DDB2 genes.
Zolezzi F, Linn S
Gene. 2000
PubMed ID: 10713455
Quality control by DNA repair.
Lindahl T, Wood RD
Science. 1999
PubMed ID: 10583946
cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells.
Seki N, Hayashi A, Hattori A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu M, Saito T
DNA Res. 1999
PubMed ID: 10574459
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
DNA damage recognition during nucleotide excision repair in mammalian cells.
Wood RD
Biochimie. 1999
PubMed ID: 10214908
p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity.
Hwang BJ, Toering S, Francke U, Chu G
Mol Cell Biol. 1998
PubMed ID: 9632823
The mouse homologs of human GIF, DDB1, and CFL1 genes are located on chromosome 19.
Fernandes M, Poirier C, Lespinasse F, Carle GF
Mamm Genome. 1998
PubMed ID: 9530637
DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1.
Hayes S, Shiyanov P, Chen X, Raychaudhuri P
Mol Cell Biol. 1998
PubMed ID: 9418871
Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype.
Nichols AF, Ong P, Linn S
J Biol Chem. 1996
PubMed ID: 8798680
Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells.
Hwang BJ, Liao JC, Chu G
Mutat Res. 1996
PubMed ID: 8538642
Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S
Genomics. 1995
PubMed ID: 8530102
Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.
Lee TH, Elledge SJ, Butel JS
J Virol. 1995
PubMed ID: 7815490
Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.
Keeney S, Eker AP, Brody T, Vermeulen W, Bootsma D, Hoeijmakers JH, Linn S
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8171034
Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.
Keeney S, Chang GJ, Linn S
J Biol Chem. 1993
PubMed ID: 8407967
Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA.
Chu G, Chang E
Science. 1988
PubMed ID: 3175673

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1642	13194	64470
EnsEMBL Gene(s)	ENSG00000167986	ENSMUSG00000024740	ENSRNOG00000020715
Unigene	Hs.290758	Mm.289915	Rn.8402
Homologene	DDB1	Ddb1	Ddb1
OMIM	600045	N/A	N/A
GeneCards	DDB1	N/A	N/A
Beta Cell Genomics	DT.100887611 DT.100887618 DT.100887634 DT.120694269 DT.87017915 DT.95139100 DT.97808133	DT.101134025 DT.101214230 DT.101267382 DT.101406550 DT.102558593 DT.495939 DT.94380516 DT.99866666	N/A
Reactome	Q16531	N/A	N/A
Plasma Peptide Atlas	ENSP00000301764	N/A	N/A
WikiGenes	1642	13194	64470

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
DDB1	HDAC5	BioGRID	empirical	21081666
DDB1	TRIM28	IntAct, BioGRID	empirical	20360068
DDB1	DCAF7	BioGRID	empirical	16949367
DDB1	CDKN1A	BioGRID	empirical	18794347 18703516
DDB1	CDKN1B	BioGRID	empirical	21237244
DDB1	CENPA	BioGRID	empirical	15009096
DDB1	NUDC	IntAct, BioGRID	empirical	20360068
DDB1	COPS8	BioGRID	empirical	16964240
DDB1	COPS6	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	COPS5	IntAct, BioGRID	empirical	20360068 18850735 16964240 16949367
DDB1	WDR5	IntAct	empirical	17041588
DDB1	KATNA1	BioGRID	empirical	19287380
DDB1	CHEK1	BioGRID	empirical	19276361
DDB1	ZNF277	BioGRID	empirical	20211142
DDB1	RASSF1	BioGRID	empirical	21205828
DDB1	GPN1	BioGRID	empirical	17643375
DDB1	GABARAP	IntAct	empirical	20562859
DDB1	ERCC8	HPRD, IntAct, BioGRID	empirical	12732143 17392787 20360068 16949367
DDB1	CTNNB1	BioGRID	empirical	19651607
DDB1	TOR1AIP2	BioGRID	empirical	16964240
DDB1	DDB1	IntAct, BioGRID	empirical	20360068
DDB1	DDB2	HPRD, IntAct, MIPS, BioGRID, Reactome	empirical	12050362 17392787 16964240 17041588 9418871 19109893 20360068 11564863 18593899 16949367 16678110 16473935 20368362 22118460 10214908 10526214 11511374
DDB1	AHR	BioGRID	empirical	19651607
DDB1	ERCC5	Reactome	predicted	10214908 10526214 11511374
DDB1	ERCC6	BioGRID	empirical	20541997
DDB1	ALB	IntAct	empirical	15174051
DDB1	MED19	IntAct	empirical	15175163
DDB1	SNW1	BioGRID	empirical	12840015
DDB1	WDTC1	HPRD, IntAct, BioGRID	empirical	16964240 20360068 16949367
DDB1	FAF2	IntAct, BioGRID	empirical	18775313
DDB1	RPGRIP1L	IntAct	empirical	21565611
DDB1	GABARAPL1	IntAct	empirical	20562859
DDB1	ABL1	HPRD	empirical	12107171
DDB1	DCAF12	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	DCAF13	BioGRID	empirical	16949367
DDB1	UBXN7	IntAct, BioGRID	empirical	18775313
DDB1	DCAF4	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	TRPC4AP	IntAct, BioGRID	empirical	20360068 16964240 20551172
DDB1	PHGDH	IntAct	empirical	20360068
DDB1	KAT2A	BioGRID	empirical	11564863 21987584
DDB1	GPS1	IntAct, BioGRID	empirical	20360068 16949367
DDB1	HNRNPK	IntAct	empirical	16518874
DDB1	HOXD3	BioGRID	empirical	20211142
DDB1	APC	IntAct	empirical	16212417
DDB1	ILK	IntAct	empirical	17353931
DDB1	GSTK1	IntAct	empirical	17353931
DDB1	SETD8	BioGRID	empirical	20932471
DDB1	MEF2A	IntAct	empirical	21988832
DDB1	MAP3K1	MINT, IntAct	empirical	14743216
DDB1	MAP3K3	MINT, IntAct	empirical	14743216
DDB1	MYC	BioGRID	empirical	20551172
DDB1	ATM	IntAct, BioGRID	empirical	20360068
DDB1	NEDD8	BioGRID	empirical	16964240 18274552
DDB1	NF2	BioGRID	empirical	18332868
DDB1	CNOT2	BioGRID	empirical	20211142
DDB1	DCAF8	HPRD, IntAct, BioGRID	empirical	16964240 20360068 16949367
DDB1	COPS7A	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	UBXN1	IntAct, BioGRID	empirical	18775313
DDB1	PCNA	BioGRID	empirical	16964240
DDB1	COPS4	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	CRBN	IntAct, BioGRID	empirical	20360068 16964240 20223979
DDB1	UBR5	BioGRID	empirical	19287380
DDB1	DTL	HPRD, IntAct, BioGRID	empirical	16964240 17041588 20360068 16949367
DDB1	BRWD1	BioGRID	empirical	16964240
DDB1	POLR2J	BioGRID	empirical	17643375
DDB1	FBXW5	BioGRID	empirical	18381890
DDB1	DDIT4	MINT	empirical	19557001
DDB1	WDR5B	IntAct	empirical	17041588
DDB1	POU5F1	IntAct, BioGRID	empirical	20362542
DDB1	INO80	IntAct	empirical	20855601
DDB1	DCAF16	IntAct, BioGRID	empirical	20360068 16949367
DDB1	DET1	HPRD, BioGRID	empirical	14739464 16964240 16949367
DDB1	USP40	HPRD	empirical	11673459
DDB1	PIDD	BioGRID	empirical	21415862
DDB1	AMBRA1	IntAct, BioGRID	empirical	20360068 20562859 16949367
DDB1	PRKAB1	IntAct	empirical	17353931
DDB1	DCAF6	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	CAND1	BioGRID	empirical	15448697
DDB1	MAPK3	MINT	empirical	19935650
DDB1	NSFL1C	IntAct	empirical	18775313
DDB1	RAG1	BioGRID	empirical	22157821
DDB1	RAG2	BioGRID	empirical	22157821
DDB1	RBBP5	IntAct, BioGRID	empirical	17041588
DDB1	RCN1	IntAct, BioGRID	empirical	20360068
DDB1	RPS9	IntAct	empirical	17461779
DDB1	SALL2	BioGRID	empirical	21228219
DDB1	RFWD2	IntAct, BioGRID	empirical	17041588 14739464 16949367
DDB1	COPS7B	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	SKP2	HPRD, BioGRID	empirical	16537899
DDB1	STAT1	IntAct	empirical	21988832
DDB1	TADA2A	BioGRID	empirical	20508642
DDB1	TERF1	BioGRID	empirical	20811636
DDB1	TERF2	BioGRID	empirical	20811636
DDB1	TLE2	IntAct	empirical	17041588
DDB1	TNFRSF1B	MINT, IntAct	empirical	14743216
DDB1	TP53	BioGRID	empirical	17967871
DDB1	TRAF6	IntAct	empirical	17353931
DDB1	UBC	BioGRID	empirical	16964240 16196087 20639865 22118674 18781797 21987572 21963094 21139048 21890473 21906983
DDB1	UNG	BioGRID	empirical	20870715
DDB1	XPA	Reactome	predicted	10214908 10526214 11511374
DDB1	XPC	BioGRID	empirical	15882621
DDB1	YWHAZ	MINT	empirical	15161933
DDB1	DDA1	IntAct, BioGRID	empirical	20360068 20562859 16964240 16949367
DDB1	DCAF10	IntAct, BioGRID	empirical	20360068 16964240 16949367
DDB1	ACTR5	IntAct	empirical	20855601
DDB1	DCAF17	BioGRID	empirical	16949367
DDB1	WDR26	IntAct	empirical	17041588
DDB1	DCAF11	HPRD, IntAct, BioGRID	empirical	16964240 19109893 20360068 16949367
DDB1	CDT1	BioGRID	empirical	15448697
DDB1	BRAP	HPRD, IntAct	empirical	10777491
DDB1	HIST1H3A	BioGRID	empirical	17041588
DDB1	DYRK2	BioGRID	empirical	19287380
DDB1	CUL4B	HPRD, IntAct, BioGRID	empirical	18593899 17041588 20360068 16964240 16949367 16678110 19651607
DDB1	CUL4A	HPRD, IntAct, BioGRID	empirical	14739464 17041588 20360068 18593899 16964240 16949367 16678110 16473935 15811626 15448697 20870715 19287380 22118460
DDB1	SUPT3H	BioGRID	empirical	11564863
DDB1	IKBKG	MINT, IntAct	empirical	14743216
DDB1	COPS3	IntAct	empirical	20360068 10777491
DDB1	LMO4	HPRD, MINT	empirical	15231748
DDB1	PAGE1	IntAct, BioGRID	empirical	20360068
DDB1	EED	IntAct, BioGRID	empirical	17041588
DDB1	DCAF5	Sanger Interaction Map	predicted	15345047
DDB1	TSC22D1	IntAct	empirical	17353931
DDB1	DCAF15	IntAct, BioGRID	empirical	20360068 16949367
DDB1	NEK9	IntAct, BioGRID	empirical	20360068
DDB1	VAMP3	HPRD, MINT, IntAct	empirical	16169070
DDB1	SNRNP40	IntAct	empirical	17041588
DDB1	IQCB1	IntAct	empirical	21565611
DDB1	VPRBP	IntAct	empirical	20360068
DDB1	KIAA0101	BioGRID	empirical	21628590
DDB1	MAFB	BioGRID	empirical	20211142
DDB1	RBX1	BioGRID	empirical	16678110 16473935 15448697 20870715 22118460