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DAXX

Gene Description:   Fas death domain-associated protein; death-domain associated protein Synonyms:   MGC150289, MGC126245, MGC126246, EAP1, MGC156601, DAXX, Daxx, DAP6, BING2 Orthologs:   Human DAXX (protein-coding), Mouse Daxx (protein-coding), Rat Daxx (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

(Human) GRCh37 - chr6:33286335..33297046 (10.71 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:34046359..34052535 (6.18 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr20:5121854..5127601 (5.75 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for DAXX: The DAXX interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs DAXX   HIPK3   HPRD, IntAct  empirical  11034606  DAXX   CALCOCO2   HPRD  empirical  12033769  DAXX   STUB1   BioGRID  empirical  19465479  DAXX   CDKN2A   IntAct, BioGRID  empirical  18583933  DAXX   MCRS1   HPRD, IntAct, BioGRID  empirical  11948183  DAXX   CENPC1   HPRD, IntAct, BioGRID  empirical  9645950  DAXX   RASSF1   HPRD, MINT, BioGRID  empirical  16810318  18566590  DAXX   PARK7   HPRD, IntAct  empirical  15983381  DAXX   CREBBP   HPRD, IntAct, BioGRID  empirical  11799127  16287980  DAXX   DAPK3   HPRD, IntAct, BioGRID  empirical  12917339  DAXX   DAXX   HPRD, IntAct  empirical  11483955  10698492  DAXX   DNMT1   HPRD  empirical  10444590  DAXX   HIPK1   HPRD, IntAct, BioGRID  empirical  12529400  DAXX   ESRRG   HPRD  empirical  15604093  DAXX   ETS1   HPRD, MINT, IntAct, MIPS, BioGRID  empirical  10698492  16861237  DAXX   HABP4   HPRD, BioGRID  empirical  16455055  DAXX   SNW1   HPRD, MINT  empirical  15878163  15604093  DAXX   FTH1   IntAct  empirical  21573799  DAXX   SERBP1   HPRD  empirical  16679534  DAXX   HIPK2   HPRD, BioGRID  empirical  14678985  19465479  DAXX   NR3C1   BioGRID  empirical  12595526  DAXX   HDAC1   HPRD, IntAct, MIPS, BioGRID  empirical  10669754  12529400  DAXX   HDAC2   HPRD, IntAct, MIPS, BioGRID  empirical  10669754  12140263  DAXX   AIRE   IntAct  empirical  20185822  DAXX   HSF1   HPRD  empirical  15016915  DAXX   HSPB1   HPRD, IntAct  empirical  11193028  11003656  DAXX   FAS   HPRD, IntAct, BioGRID  empirical  11193028  9215629  11483955  11003656  11495919  DAXX   FASLG   HPRD  empirical  9215629  DAXX   AR   HPRD, IntAct  empirical  15572661  15350595  DAXX   SMAD4   BioGRID  empirical  15637079  DAXX   MDM2   HPRD, MINT, IntAct, BioGRID  empirical  16845383  18566590  20195357  18583933  15364927  DAXX   MAP3K5   HPRD, IntAct, BioGRID  empirical  9743501  11003656  11495919  DAXX   MX1   HPRD, BioGRID  empirical  11716541  DAXX   MYH11   IntAct, BioGRID  empirical  20936779  DAXX   PAX3   HPRD, BioGRID  empirical  11244500  10393185  DAXX   PAX5   HPRD, IntAct, BioGRID  empirical  11799127  DAXX   PLAGL1   BioGRID  empirical  20097304  DAXX   PML   HPRD, IntAct, MIPS, BioGRID  empirical  10684855  10669754  10525530  12595526  15350595  21840486  14517282  12529400  11244500  DAXX   ATRX   HPRD, IntAct  empirical  12953102  DAXX   DMAP1   HPRD, BioGRID  empirical  14978102  20211142  DAXX   RELB   BioGRID  empirical  16982744  DAXX   SLC2A4   HPRD, MINT, IntAct, BioGRID  empirical  11842083  DAXX   SPN   HPRD  empirical  11773067  DAXX   STAT3   HPRD, IntAct  empirical  16331268  DAXX   TCF4   BioGRID  empirical  20211142  DAXX   TCF3   BioGRID  empirical  19308989  DAXX   TCF7L2   HPRD, IntAct  empirical  16569639  DAXX   TGFB1   HPRD  empirical  11483955  DAXX   TGFB2   BioGRID  empirical  11483955  DAXX   TGFBR2   HPRD, IntAct  empirical  11483955  DAXX   TP53   HPRD, MINT, IntAct, BioGRID  empirical  12954772  17289031  16845383  15364927  14557665  18566590  DAXX   TP73   HPRD  empirical  12954772  DAXX   TSG101   HPRD, IntAct  empirical  15033475  DAXX   UBC   MINT, IntAct, BioGRID  empirical  16810318  20936779  18583933  19465479  DAXX   UBE2I   HPRD, IntAct, BioGRID  empirical  11112409  12150977  18691969  DAXX   SUMO1   HPRD, MINT, IntAct  empirical  11112409  11948183  12150977  17289031  DAXX   USP7   HPRD, IntAct  empirical  16845383  DAXX   DEK   IntAct, BioGRID  empirical  12140263  DAXX   AXIN1   BioGRID  empirical  17210684  DAXX   SPOP   IntAct  empirical  21573799  DAXX   TP63   HPRD  empirical  12954772  DAXX   CFLAR   HPRD  empirical  14637155  DAXX   HDAC3   HPRD, MIPS, BioGRID  empirical  10669754  DAXX   BTBD6   IntAct  empirical  21573799  DAXX   CREB3L1   BioGRID  empirical  20211142  DAXX   ACVR2A   IntAct  empirical  11483955

View all

KEGG Network: 2   Amyotrophic lateral sclerosis (ALS) Human - 5014 Mouse - 5014 Rat - 5014 MAPK signaling pathway Human - 4010 Mouse - 4010 Rat - 4010

Biocarta: 7   FAS signaling pathway ( CD95 ) Human Mouse HIV-I Nef: negative effector of Fas and TNF Human Mouse Keratinocyte Differentiation Human Mouse MAPKinase Signaling Pathway Human Mouse p38 MAPK Signaling Pathway Human Mouse Regulation of transcriptional activity by PML Human Mouse Stress Induction of HSP Regulation Human Mouse

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: 3   TGF-beta receptor signaling HIV-1 Nef: Negative effector of Fas and TNF-alpha p53 pathway

Gene Ontology: 32   Cytokinesis after mitosis GO:0000281 Chromosome, centromeric region GO:0000775 Heterochromatin GO:0000792 P53 binding GO:0002039 Receptor signaling protein activity GO:0005057 Protein binding GO:0005515 Nucleus GO:0005634 Nucleoplasm GO:0005654 Chromosome GO:0005694 Nucleolus GO:0005730 Cytoplasm GO:0005737 Cytosol GO:0005829 Cell cortex GO:0005938 Regulation of transcription, DNA-dependent GO:0006355 Apoptosis GO:0006915 Induction of apoptosis GO:0006917 Activation of JUN kinase activity GO:0007257 Transcription factor binding GO:0008134 Induction of apoptosis via death domain receptors GO:0008625 PML body GO:0016605 Enzyme binding GO:0019899 Androgen receptor signaling pathway GO:0030521 Heat shock protein binding GO:0031072 Regulation of protein ubiquitination GO:0031396 Ubiquitin protein ligase binding GO:0031625 Protein homodimerization activity GO:0042803 Neuron projection GO:0043005 Cell body GO:0044297 Interspecies interaction between organisms GO:0044419 Negative regulation of transcription, DNA-dependent GO:0045892 Protein N-terminus binding GO:0047485 Androgen receptor binding GO:0050681

	KEGG Network: 2 Amyotrophic lateral sclerosis (ALS) Human - 5014 Mouse - 5014 Rat - 5014 MAPK signaling pathway Human - 4010 Mouse - 4010 Rat - 4010
	Biocarta: 7 FAS signaling pathway ( CD95 ) Human Mouse HIV-I Nef: negative effector of Fas and TNF Human Mouse Keratinocyte Differentiation Human Mouse MAPKinase Signaling Pathway Human Mouse p38 MAPK Signaling Pathway Human Mouse Regulation of transcriptional activity by PML Human Mouse Stress Induction of HSP Regulation Human Mouse
	Reactome: None available
	NCI-Nature Pathway Interaction Database: 3 TGF-beta receptor signaling HIV-1 Nef: Negative effector of Fas and TNF-alpha p53 pathway
	Gene Ontology: 32 Cytokinesis after mitosis GO:0000281 Chromosome, centromeric region GO:0000775 Heterochromatin GO:0000792 P53 binding GO:0002039 Receptor signaling protein activity GO:0005057 Protein binding GO:0005515 Nucleus GO:0005634 Nucleoplasm GO:0005654 Chromosome GO:0005694 Nucleolus GO:0005730 Cytoplasm GO:0005737 Cytosol GO:0005829 Cell cortex GO:0005938 Regulation of transcription, DNA-dependent GO:0006355 Apoptosis GO:0006915 Induction of apoptosis GO:0006917 Activation of JUN kinase activity GO:0007257 Transcription factor binding GO:0008134 Induction of apoptosis via death domain receptors GO:0008625 PML body GO:0016605 Enzyme binding GO:0019899 Androgen receptor signaling pathway GO:0030521 Heat shock protein binding GO:0031072 Regulation of protein ubiquitination GO:0031396 Ubiquitin protein ligase binding GO:0031625 Protein homodimerization activity GO:0042803 Neuron projection GO:0043005 Cell body GO:0044297 Interspecies interaction between organisms GO:0044419 Negative regulation of transcription, DNA-dependent GO:0045892 Protein N-terminus binding GO:0047485 Androgen receptor binding GO:0050681

Type 1 Diabetes Publications: 1

• Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.
  van der Slik AR, van den Eng I, Eerligh P, Doxiadis II, Koeleman BP, Roep BO, Giphart MJ
  Tissue Antigens. 2007
  PubMed ID: 17389020
   
  

Publications: 191

• Altered telomeres in tumors with ATRX and DAXX mutations.
  Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK
  Science. 2011
  PubMed ID: 21719641
   
  
• Daxx-beta and Daxx-gamma, two novel splice variants of the transcriptional co-repressor Daxx.
  Wethkamp N, Hanenberg H, Funke S, Suschek CV, Wetzel W, Heikaus S, Grinstein E, Ramp U, Engers R, Gabbert HE, Mahotka C
  J Biol Chem. 2011
  PubMed ID: 21482821
   
  
• Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX.
  Escobar-Cabrera E, Okon M, Lau DK, Dart CF, Bonvin AM, McIntosh LP
  J Biol Chem. 2011
  PubMed ID: 21383010
   
  
• Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.
  Chang CC, Naik MT, Huang YS, Jeng JC, Liao PH, Kuo HY, Ho CC, Hsieh YL, Lin CH, Huang NJ, Naik NM, Kung CC, Lin SY, Chen RH, Chang KS, Huang TH, Shih HM
  Mol Cell. 2011
  PubMed ID: 21474068
   
  
• NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx.
  Naik MT, Chang CC, Naik NM, Kung CC, Shih HM, Huang TH
  Biomol NMR Assign. 2011
  PubMed ID: 20927612
   
  
• DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
  Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, Schulick RD, Tang LH, Wolfgang CL, Choti MA, Velculescu VE, Diaz LA, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N
  Science. 2011
  PubMed ID: 21252315
   
  
• Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.
  Yun HJ, Yoon JH, Lee JK, Noh KT, Yoon KW, Oh SP, Oh HJ, Chae JS, Hwang SG, Kim EH, Maul GG, Lim DS, Choi EJ
  EMBO J. 2011
  PubMed ID: 21572393
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C.
  Escobar-Cabrera E, Lau DK, Giovinazzi S, Ishov AM, McIntosh LP
  Structure. 2010
  PubMed ID: 21134643
   
  
• Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells.
  Muromoto R, Kuroda M, Togi S, Sekine Y, Nanbo A, Shimoda K, Oritani K, Matsuda T
  Eur J Immunol. 2010
  PubMed ID: 21108476
   
  
• A human MAP kinase interactome.
  Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
  Nat Methods. 2010
  PubMed ID: 20936779
   
  
• Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
  Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20651253
   
  
• DJ-1 loss by glutaredoxin but not glutathione depletion triggers Daxx translocation and cell death.
  Saeed U, Ray A, Valli RK, Kumar AM, Ravindranath V
  Antioxid Redox Signal. 2010
  PubMed ID: 20014998
   
  
• Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells.
  Schreiner S, Wimmer P, Sirma H, Everett RD, Blanchette P, Groitl P, Dobner T
  J Virol. 2010
  PubMed ID: 20484509
   
  
• Human cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection.
  Reeves M, Woodhall D, Compton T, Sinclair J
  J Virol. 2010
  PubMed ID: 20444888
   
  
• The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
  Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A
  Genes Dev. 2010
  PubMed ID: 20504901
   
  
• Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations.
  Ho CL, Huang YC, Tai CK, Liu ST, Wang JK, Wang WM, Huang SM
  Int J Biochem Cell Biol. 2010
  PubMed ID: 20097304
   
  
• DAXX is a new AIRE-interacting protein.
  Meloni A, Meloni A, Fiorillo E, Corda D, Incani F, Serra ML, Contini A, Cao A, Rosatelli MC
  J Biol Chem. 2010
  PubMed ID: 20185822
   
  
• Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx.
  Lukashchuk V, Everett RD
  J Virol. 2010
  PubMed ID: 20147399
   
  
• Daxx is reciprocally regulated by Mdm2 and Hausp.
  Tang J, Qu L, Pang M, Yang X
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20153724
   
  
• An atlas of combinatorial transcriptional regulation in mouse and man.
  Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
  Cell. 2010
  PubMed ID: 20211142
   
  
• Distinct factors control histone variant H3.3 localization at specific genomic regions.
  Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD
  Cell. 2010
  PubMed ID: 20211137
   
  
• Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis.
  Netsawang J, Noisakran S, Puttikhunt C, Kasinrerk W, Wongwiwat W, Malasit P, Yenchitsomanus PT, Limjindaporn T
  Virus Res. 2010
  PubMed ID: 19944121
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• Analysis of interaction partners of H4 histone by a new proteomics approach.
  Saade E, Mechold U, Kulyyassov A, Vertut D, Lipinski M, Ogryzko V
  Proteomics. 2009
  PubMed ID: 19862764
   
  
• TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility.
  Do TN, Ucisik-Akkaya E, Davis CF, Morrison BA, Dorak MT
  Cancer Genet Cytogenet. 2009
  PubMed ID: 19837266
   
  
• Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta.
  Wethkamp N, Klempnauer KH
  J Biol Chem. 2009
  PubMed ID: 19690170
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• Daxx positively modulates beta-catenin/TCF4-mediated transcriptional potential.
  Huang YS, Shih HM
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19563778
   
  
• Lysine acetylation targets protein complexes and co-regulates major cellular functions.
  Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
  Science. 2009
  PubMed ID: 19608861
   
  
• Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program.
  McDonough H, Charles PC, Hilliard EG, Qian SB, Min JN, Portbury A, Cyr DM, Patterson C
  J Biol Chem. 2009
  PubMed ID: 19465479
   
  
• Human cytomegalovirus protein pp71 induces Daxx SUMOylation.
  Hwang J, Kalejta RF
  J Virol. 2009
  PubMed ID: 19369322
   
  
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
  Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
  Anal Chem. 2009
  PubMed ID: 19413330
   
  
• Daxx inhibits muscle differentiation by repressing E2A-mediated transcription.
  Gupta A, Hou R, Liu L, Hiroyasu S, Hadix JA, Huggins GS, Sibinga NE
  J Cell Biochem. 2009
  PubMed ID: 19308989
   
  
• Daxx is a predominately nuclear protein that does not translocate to the cytoplasm in response to cell stress.
  Lindsay CR, Giovinazzi S, Ishov AM
  Cell Cycle. 2009
  PubMed ID: 19372739
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.
  Ouyang J, Shi Y, Valin A, Xuan Y, Gill G
  Mol Cell. 2009
  PubMed ID: 19394292
   
  
• Daxx functions as a scaffold of a protein assembly constituted by GLUT4, JNK1 and KIF5B.
  Lalioti VS, Vergarajauregui S, Tsuchiya Y, Hernandez-Tiedra S, Sandoval IV
  J Cell Physiol. 2009
  PubMed ID: 18932217
   
  
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
  Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
  Sci Signal. 2009
  PubMed ID: 19690332
   
  
• Identification of two independent SUMO-interacting motifs in Daxx: evolutionary conservation from Drosophila to humans and their biochemical functions.
  Santiago A, Godsey AC, Hossain J, Zhao LY, Liao D
  Cell Cycle. 2009
  PubMed ID: 19106612
   
  
• Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.
  Lukashchuk V, McFarlane S, Everett RD, Preston CM
  J Virol. 2008
  PubMed ID: 18922870
   
  
• Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
  Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
  Genome Res. 2008
  PubMed ID: 18799693
   
  
• Daxx interacts with HIV-1 integrase and inhibits lentiviral gene expression.
  Huang L, Xu GL, Zhang JQ, Tian L, Xue JL, Chen JZ, Jia W
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18558084
   
  
• Ubc9 sumoylation regulates SUMO target discrimination.
  Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A
  Mol Cell. 2008
  PubMed ID: 18691969
   
  
• A quantitative atlas of mitotic phosphorylation.
  Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18669648
   
  
• Induction of proapoptotic Daxx following ischemic acute kidney injury.
  Ma Q, Devarajan P
  Kidney Int. 2008
  PubMed ID: 18480747
   
  
• Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.
  Ullman AJ, Hearing P
  J Virol. 2008
  PubMed ID: 18480450
   
  
• The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.
  Song MS, Song SJ, Kim SY, Oh HJ, Lim DS
  EMBO J. 2008
  PubMed ID: 18566590
   
  
• p14ARF interacts with DAXX: effects on HDM2 and p53.
  Ivanchuk SM, Mondal S, Rutka JT
  Cell Cycle. 2008
  PubMed ID: 18583933
   
  
• Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.
  Puto LA, Reed JC
  Genes Dev. 2008
  PubMed ID: 18413714
   
  
• Regulation of c-met expression by transcription repressor Daxx.
  Morozov VM, Massoll NA, Vladimirova OV, Maul GG, Ishov AM
  Oncogene. 2008
  PubMed ID: 17952115
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
  Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
  J Proteome Res. 2008
  PubMed ID: 18220336
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Daxx contains two nuclear localization signals and interacts with importin alpha3.
  Yeung PL, Chen LY, Tsai SC, Zhang A, Chen JD
  J Cell Biochem. 2008
  PubMed ID: 17661348
   
  
• Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats.
  Bi FF, Xiao B, Hu YQ, Tian FF, Wu ZG, Ding L, Zhou XF
  Brain Res. 2008
  PubMed ID: 18096138
   
  
• Effect of Daxx on cholesterol accumulation in hepatic cells.
  Tuo QH, Liang L, Zhu BY, Cao X, Liao DF
  World J Gastroenterol. 2008
  PubMed ID: 18200667
   
  
• Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death.
  Jung YS, Kim HY, Kim J, Lee MG, Pouysségur J, Kim E
  J Biol Chem. 2008
  PubMed ID: 18003619
   
  
• Daxx inhibits stress-induced apoptosis in cardiac myocytes.
  Zobalova R, Swettenham E, Chladova J, Dong LF, Neuzil J
  Redox Rep. 2008
  PubMed ID: 19017466
   
  
• PML NBs (ND10) and Daxx: from nuclear structure to protein function.
  Lindsay CR, Morozov VM, Ishov AM
  Front Biosci. 2008
  PubMed ID: 18508722
   
  
• Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection.
  Tavalai N, Papior P, Rechter S, Stamminger T
  J Virol. 2008
  PubMed ID: 17942542
   
  
• A suppressive role of the prolyl isomerase Pin1 in cellular apoptosis mediated by the death-associated protein Daxx.
  Ryo A, Hirai A, Nishi M, Liou YC, Perrem K, Lin SC, Hirano H, Lee SW, Aoki I
  J Biol Chem. 2007
  PubMed ID: 17938171
   
  
• Myocardial expression of a dominant-negative form of Daxx decreases infarct size and attenuates apoptosis in an in vivo mouse model of ischemia/reperfusion injury.
  Roubille F, Combes S, Leal-Sanchez J, Barrère C, Cransac F, Sportouch-Dukhan C, Gahide G, Serre I, Kupfer E, Richard S, Hueber AO, Nargeot J, Piot C, Barrère-Lemaire S
  Circulation. 2007
  PubMed ID: 18025529
   
  
• Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization.
  Shih HM, Chang CC, Kuo HY, Lin DY
  Biochem Soc Trans. 2007
  PubMed ID: 18031230
   
  
• Knockdown of hDaxx in normally non-permissive undifferentiated cells does not permit human cytomegalovirus immediate-early gene expression.
  Groves IJ, Sinclair JH
  J Gen Virol. 2007
  PubMed ID: 17947514
   
  
• Sensitization to Fas-mediated apoptosis by dengue virus capsid protein.
  Limjindaporn T, Netsawang J, Noisakran S, Thiemmeca S, Wongwiwat W, Sudsaward S, Avirutnan P, Puttikhunt C, Kasinrerk W, Sriburi R, Sittisombut N, Yenchitsomanus PT, Malasit P
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17707345
   
  
• Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro.
  Saffert RT, Kalejta RF
  J Virol. 2007
  PubMed ID: 17596307
   
  
• ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
  Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
  Science. 2007
  PubMed ID: 17525332
   
  
• Daxx shortens mitotic arrest caused by paclitaxel.
  Lindsay CR, Scholz A, Morozov VM, Ishov AM
  Cell Cycle. 2007
  PubMed ID: 17471023
   
  
• Inhibition of NF-kappaB acetylation and its transcriptional activity by Daxx.
  Park J, Lee JH, La M, Jang MJ, Chae GW, Kim SB, Tak H, Jung Y, Byun B, Ahn JK, Joe CO
  J Mol Biol. 2007
  PubMed ID: 17362989
   
  
• Axin bridges Daxx to p53.
  Lin SC, Li Q
  Cell Res. 2007
  PubMed ID: 17404597
   
  
• Requirement for Daxx in mature T-cell proliferation and activation.
  Leal-Sanchez J, Couzinet A, Rossin A, Abdel-Sater F, Chakrabandhu K, Luci C, Anjuere F, Stebe E, Hancock D, Hueber AO
  Cell Death Differ. 2007
  PubMed ID: 17082815
   
  
• Subcellular localization of Daxx determines its opposing functions in ischemic cell death.
  Jung YS, Kim HY, Lee YJ, Kim E
  FEBS Lett. 2007
  PubMed ID: 17289031
   
  
• Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.
  Molina H, Horn DM, Tang N, Mathivanan S, Pandey A
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17287340
   
  
• A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis.
  Fisher P, Hedeler C, Wolstencroft K, Hulme H, Noyes H, Kemp S, Stevens R, Brass A
  Nucleic Acids Res. 2007
  PubMed ID: 17709344
   
  
• Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.
  Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou YC, Ye Z, Lin SC
  Cancer Res. 2007
  PubMed ID: 17210684
   
  
• Human Daxx-mediated repression of human cytomegalovirus gene expression correlates with a repressive chromatin structure around the major immediate early promoter.
  Woodhall DL, Groves IJ, Reeves MB, Wilkinson G, Sinclair JH
  J Biol Chem. 2006
  PubMed ID: 17035242
   
  
• Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.
  Lin DY, Huang YS, Jeng JC, Kuo HY, Chang CC, Chao TT, Ho CC, Chen YC, Lin TP, Fang HI, Hung CC, Suen CS, Hwang MJ, Chang KS, Maul GG, Shih HM
  Mol Cell. 2006
  PubMed ID: 17081986
   
  
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
  Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
  Cell. 2006
  PubMed ID: 17081983
   
  
• Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
  Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB
  Genes Dev. 2006
  PubMed ID: 17015433
   
  
• Ets-1-dependent expression of vascular endothelial growth factor receptors is activated by latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus through interaction with Daxx.
  Murakami Y, Yamagoe S, Noguchi K, Takebe Y, Takahashi N, Uehara Y, Fukazawa H
  J Biol Chem. 2006
  PubMed ID: 16861237
   
  
• Daxx represses expression of a subset of antiapoptotic genes regulated by nuclear factor-kappaB.
  Croxton R, Puto LA, de Belle I, Thomas M, Torii S, Hanaii F, Cuddy M, Reed JC
  Cancer Res. 2006
  PubMed ID: 16982744
   
  
• Critical role for Daxx in regulating Mdm2.
  Tang J, Qu LK, Zhang J, Wang W, Michaelson JS, Degenhardt YY, El-Deiry WS, Yang X
  Nat Cell Biol. 2006
  PubMed ID: 16845383
   
  
• Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
  Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H
  EMBO J. 2006
  PubMed ID: 16810318
   
  
• Sumoylation of Daxx regulates IFN-induced growth suppression of B lymphocytes and the hormone receptor-mediated transactivation.
  Muromoto R, Ishida M, Sugiyama K, Sekine Y, Oritani K, Shimoda K, Matsuda T
  J Immunol. 2006
  PubMed ID: 16818774
   
  
• SUMO regulates the cytoplasmonuclear transport of its target protein Daxx.
  Chen A, Wang PY, Yang YC, Huang YH, Yeh JJ, Chou YH, Cheng JT, Hong YR, Li SS
  J Cell Biochem. 2006
  PubMed ID: 16475184
   
  
• Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells.
  Tzeng SL, Cheng YW, Li CH, Lin YS, Hsu HC, Kang JJ
  J Biol Chem. 2006
  PubMed ID: 16569639
   
  
• Human cytomegalovirus (HCMV) UL82 gene product (pp71) relieves hDaxx-mediated repression of HCMV replication.
  Cantrell SR, Bresnahan WA
  J Virol. 2006
  PubMed ID: 16731959
   
  
• BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
  Kwon JE, La M, Oh KH, Oh YM, Kim GR, Seol JH, Baek SH, Chiba T, Tanaka K, Bang OS, Joe CO, Chung CH
  J Biol Chem. 2006
  PubMed ID: 16524876
   
  
• Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL.
  Raoul C, Buhler E, Sadeghi C, Jacquier A, Aebischer P, Pettmann B, Henderson CE, Haase G
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16581901
   
  
• The PML-nuclear body associated protein Daxx regulates the cellular response to CD40.
  Salomoni P, Guernah I, Pandolfi PP
  Cell Death Differ. 2006
  PubMed ID: 16311507
   
  
• Physical and functional interactions between Daxx and STAT3.
  Muromoto R, Nakao K, Watanabe T, Sato N, Sekine Y, Sugiyama K, Oritani K, Shimoda K, Matsuda T
  Oncogene. 2006
  PubMed ID: 16331268
   
  
• Evidence for the interaction of the regulatory protein Ki-1/57 with p53 and its interacting proteins.
  Nery FC, Rui E, Kuniyoshi TM, Kobarg J
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16455055
   
  
• Daxx: death or survival protein?
  Salomoni P, Khelifi AF
  Trends Cell Biol. 2006
  PubMed ID: 16406523
   
  
• CGI-55 interacts with nuclear proteins and co-localizes to p80-coilin positive-coiled bodies in the nucleus.
  Lemos TA, Kobarg J
  Cell Biochem Biophys. 2006
  PubMed ID: 16679534
   
  
• SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
  Kuo HY, Chang CC, Jeng JC, Hu HM, Lin DY, Maul GG, Kwok RP, Shih HM
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16287980
   
  
• Upregulation of Daxx mediates apoptosis in response to oxidative stress.
  Kim KS, Hwang HA, Chae SK, Ha H, Kwon KS
  J Cell Biochem. 2005
  PubMed ID: 16088932
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb.
  Subramanian S, Yim YS, Liu K, Tus K, Zhou XJ, Wakeland EK
  J Immunol. 2005
  PubMed ID: 16002707
   
  
• Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.
  Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 15983381
   
  
• Daxx is required for stress-induced cell death and JNK activation.
  Khelifi AF, D'Alcontres MS, Salomoni P
  Cell Death Differ. 2005
  PubMed ID: 15861194
   
  
• Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replication.
  Cantrell SR, Bresnahan WA
  J Virol. 2005
  PubMed ID: 15919932
   
  
• The death domain-associated protein modulates activity of the transcription co-factor Skip/NcoA62.
  Tang J, Chang HY, Yang X
  FEBS Lett. 2005
  PubMed ID: 15878163
   
  
• The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription.
  Greger JG, Katz RA, Ishov AM, Maul GG, Skalka AM
  J Virol. 2005
  PubMed ID: 15795247
   
  
• Differential effects of a novel IFN-zeta/limitin and IFN-alpha on signals for Daxx induction and Crk phosphorylation that couple with growth control of megakaryocytes.
  Ishida N, Oritani K, Shiraga M, Yoshida H, Kawamoto S, Ujiie H, Masaie H, Ichii M, Tomiyama Y, Kanakura Y
  Exp Hematol. 2005
  PubMed ID: 15781341
   
  
• Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4.
  Chang CC, Lin DY, Fang HI, Chen RH, Shih HM
  J Biol Chem. 2005
  PubMed ID: 15637079
   
  
• Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
  Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, Kern R, Koegl M
  Mol Cell Proteomics. 2005
  PubMed ID: 15604093
   
  
• Gene and alternative splicing annotation with AIR.
  Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
  Genome Res. 2005
  PubMed ID: 15632090
   
  
• Negative modulation of androgen receptor transcriptional activity by Daxx.
  Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM
  Mol Cell Biol. 2004
  PubMed ID: 15572661
   
  
• Negative regulation of p53 functions by Daxx and the involvement of MDM2.
  Zhao LY, Liu J, Sidhu GS, Niu Y, Liu Y, Wang R, Liao D
  J Biol Chem. 2004
  PubMed ID: 15364927
   
  
• The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.
  Gostissa M, Morelli M, Mantovani F, Guida E, Piazza S, Collavin L, Brancolini C, Schneider C, Del Sal G
  J Biol Chem. 2004
  PubMed ID: 15339933
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.
  Yordy JS, Li R, Sementchenko VI, Pei H, Muise-Helmericks RC, Watson DK
  Oncogene. 2004
  PubMed ID: 15247905
   
  
• Large-scale characterization of HeLa cell nuclear phosphoproteins.
  Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15302935
   
  
• Daxx deletion mutant (amino acids 501-625)-induced apoptosis occurs through the JNK/p38-Bax-dependent mitochondrial pathway.
  Song JJ, Lee YJ
  J Cell Biochem. 2004
  PubMed ID: 15258908
   
  
• Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX.
  Ishov AM, Vladimirova OV, Maul GG
  J Cell Sci. 2004
  PubMed ID: 15252119
   
  
• Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.
  La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO
  Biochem Biophys Res Commun. 2004
  PubMed ID: 15240113
   
  
• Tryptophan 621 and serine 667 residues of Daxx regulate its nuclear export during glucose deprivation.
  Song JJ, Lee YJ
  J Biol Chem. 2004
  PubMed ID: 15128734
   
  
• A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.
  Tang J, Wu S, Liu H, Stratt R, Barak OG, Shiekhattar R, Picketts DJ, Yang X
  J Biol Chem. 2004
  PubMed ID: 14990586
   
  
• Physical and functional interactions between Daxx and TSG101.
  Muromoto R, Sugiyama K, Yamamoto T, Oritani K, Shimoda K, Matsuda T
  Biochem Biophys Res Commun. 2004
  PubMed ID: 15033475
   
  
• Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.
  Abe K, Yuzuriha M, Sugimoto M, Ko MS, Brathwaite M, Waeltz P, Nagaraja R
  Mamm Genome. 2004
  PubMed ID: 15112104
   
  
• The genomic sequence and comparative analysis of the rat major histocompatibility complex.
  Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H
  Genome Res. 2004
  PubMed ID: 15060004
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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• Physical and functional interactions between Daxx and DNA methyltransferase 1-associated protein, DMAP1.
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• Fas gene mutations in mycosis fungoides: analysis of laser capture-microdissected specimens from cutaneous lesions.
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• Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor.
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• Long form of cellular FLICE-inhibitory protein interacts with Daxx and prevents Fas-induced JNK activation.
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• HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
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• Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx.
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• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
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• Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.
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• Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.
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• The DNA sequence and analysis of human chromosome 6.
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• Daxx silencing sensitizes cells to multiple apoptotic pathways.
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• Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
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• The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.
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• Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.
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• ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
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• Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential.
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• Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.
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• Daxx enhances Fas-mediated apoptosis in a murine pro-B cell line, BAF3.
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• Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
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• Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.
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• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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  Nature. 2002
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• Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation.
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• Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.
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• Daxx-mediated accumulation of human cytomegalovirus tegument protein pp71 at ND10 facilitates initiation of viral infection at these nuclear domains.
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• Modification of Daxx by small ubiquitin-related modifier-1.
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• Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.
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• A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
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• The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.
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• Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.
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• The interaction of Pax5 (BSAP) with Daxx can result in transcriptional activation in B cells.
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• Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules.
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• Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.
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• Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies.
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• Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.
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• TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
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