CYBB

Summary Top Help

Gene Description:

cytochrome b-245, beta polypeptide

Synonyms:

CYBB, CGD, GP91-PHOX, Cyd, Cgd, Gp91-phox, gp91phox, p91-PHOX, GP91PHOX, Nox2, NOX2, AMCBX2, Cybb, GP91-1, C88302

Orthologs:

Human CYBB (protein-coding), Mouse Cybb (protein-coding), Rat Cybb (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Unnamed ChrX	Rat	chrX:23104745..86104983	63.00	362	1 Non-significant for backcross

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chrX:37639264..37672714 (33.45 kb) View in Genome Browser

(Mouse) NCBIM37 - chrX:9012378..9064897 (52.52 kb) View in Genome Browser

(Rat) RGSC3.4 - chrX:25514572..25547181 (32.61 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CYBB:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CYBB:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 27

Publications from PubMed Top Help

Type 1 Diabetes Publications: 4

Publications: 502

NAD(P)H oxidase and eNOS play differential roles in cytomegalovirus infection-induced microvascular dysfunction.
Leskov IL, Whitsett J, Vasquez-Vivar J, Stokes KY
Free Radic Biol Med. 2011
PubMed ID: 22033010
Absence of phagocyte NADPH oxidase 2 leads to severe inflammatory response in lungs of mice infected with Coccidioides.
Gonzalez A, Hung CY, Cole GT
Microb Pathog. 2011
PubMed ID: 21896326
Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.
Ueyama T, Nakakita J, Nakamura T, Kobayashi T, Kobayashi T, Son J, Sakuma M, Sakaguchi H, Leto TL, Saito N
J Biol Chem. 2011
PubMed ID: 21956105
Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.
Guemez-Gamboa A, Estrada-Sánchez AM, Montiel T, Páramo B, Massieu L, Morán J
J Neuropathol Exp Neurol. 2011
PubMed ID: 22002428
Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells.
Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, Scott MJ, Billiar TR, Wilson MA, Fan J
J Immunol. 2011
PubMed ID: 21940680
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
Balteau M, Tajeddine N, de Meester C, Ginion A, Des Rosiers C, Brady NR, Sommereyns C, Horman S, Vanoverschelde JL, Gailly P, Hue L, Bertrand L, Beauloye C
Cardiovasc Res. 2011
PubMed ID: 21859816
Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia.
Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR
J Cell Physiol. 2011
PubMed ID: 21302291
Significance of marrow-derived nicotinamide adenine dinucleotide phosphate oxidase in experimental ischemic stroke.
Tang XN, Zheng Z, Giffard RG, Yenari MA
Ann Neurol. 2011
PubMed ID: 22028221
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.
Wang X, Son YO, Chang Q, Sun L, Hitron JA, Budhraja A, Zhang Z, Ke Z, Chen F, Luo J, Shi X
Toxicol Sci. 2011
PubMed ID: 21742780
Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4.
Sun QA, Hess DT, Nogueira L, Yong S, Bowles DE, Eu J, Laurita KR, Meissner G, Stamler JS
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896730
X-ROS signaling: rapid mechano-chemo transduction in heart.
Prosser BL, Ward CW, Lederer WJ
Science. 2011
PubMed ID: 21903813
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells.
Toller IM, Neelsen KJ, Steger M, Hartung ML, Hottiger MO, Stucki M, Kalali B, Gerhard M, Sartori AA, Lopes M, Müller A
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896770
Adaptive immune defects against glycoantigens in chronic granulomatous disease via dysregulated nitric oxide production.
Lewis CJ, Cobb BA
Eur J Immunol. 2011
PubMed ID: 21630251
Nox2-derived ROS in PPARγ signaling and cell-cycle progression of lung alveolar epithelial cells.
Tickner J, Fan LM, Du J, Meijles D, Li JM
Free Radic Biol Med. 2011
PubMed ID: 21664456
Anoxia-reoxygenation enhances platelet thromboxane A2 production via reactive oxygen species-generated NOX2: effect in patients undergoing elective percutaneous coronary intervention.
Basili S, Pignatelli P, Tanzilli G, Mangieri E, Carnevale R, Nocella C, Di Santo S, Pastori D, Ferroni P, Violi F
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21636808
NADPH oxidase pathway is involved in aortic contraction induced by A3 adenosine receptor in mice.
El-Awady MS, Ansari HR, Fil D, Tilley SL, Mustafa SJ
J Pharmacol Exp Ther. 2011
PubMed ID: 21606175
Two X-linked chronic granulomatous disease patients with unusual NADPH oxidase properties.
Wolach B, Broides A, Zeeli T, Gavrieli R, de Boer M, van Leeuwen K, Levy J, Roos D
J Clin Immunol. 2011
PubMed ID: 21604087
Sphingolipid degradation by Leishmania major is required for its resistance to acidic pH in the mammalian host.
Xu W, Xin L, Soong L, Zhang K
Infect Immun. 2011
PubMed ID: 21576322
Nox2-derived reactive oxygen species contribute to hypercholesterolemia-induced inhibition of neovascularization: effects on endothelial progenitor cells and mature endothelial cells.
Haddad P, Dussault S, Groleau J, Turgeon J, Maingrette F, Rivard A
Atherosclerosis. 2011
PubMed ID: 21524749
Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome.
Bauernfeind F, Bartok E, Rieger A, Franchi L, Núñez G, Hornung V
J Immunol. 2011
PubMed ID: 21677136
SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.
Kim HJ, Yun J, Lee J, Hong H, Jeong J, Kim E, Bae YS, Lee KJ
Biochem Biophys Res Commun. 2011
PubMed ID: 21683690
Coupling of 6-phosphogluconate dehydrogenase with NADPH oxidase in neutrophils: Nox2 activity regulation by NADPH availability.
Baillet A, Xu R, Grichine A, Berthier S, Morel F, Paclet MH
FASEB J. 2011
PubMed ID: 21444627
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Distinct role of nitric oxide and peroxynitrite in mediating oligodendrocyte toxicity in culture and in experimental autoimmune encephalomyelitis.
Li S, Vana AC, Ribeiro R, Zhang Y
Neuroscience. 2011
PubMed ID: 21511012
Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells.
Lee K, Won HY, Bae MA, Hong JH, Hwang ES
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21593419
Hemophagocytosis causes a consumptive anemia of inflammation.
Zoller EE, Lykens JE, Terrell CE, Aliberti J, Filipovich AH, Henson PM, Jordan MB
J Exp Med. 2011
PubMed ID: 21624938
Role of p47phox in antigen-presenting cell-mediated regulation of humoral immunity in mice.
Vasilevsky S, Liu Q, Koontz SM, Kastenmayer R, Shea K, Jackson SH
Am J Pathol. 2011
PubMed ID: 21641399
Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction.
Murdoch CE, Alom-Ruiz SP, Wang M, Zhang M, Walker S, Yu B, Brewer A, Shah AM
Basic Res Cardiol. 2011
PubMed ID: 21528437
Female X-chromosome mosaicism for NOX2 deficiency presents unique inflammatory phenotype and improves outcome in polymicrobial sepsis.
Chandra R, Federici S, Németh ZH, Horváth B, Pacher P, Haskó G, Deitch EA, Spolarics Z
J Immunol. 2011
PubMed ID: 21502376
Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues.
Zhang WJ, Wei H, Tien YT, Frei B
Free Radic Biol Med. 2011
PubMed ID: 21376114
Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy.
Shanmugam P, Valente AJ, Prabhu SD, Venkatesan B, Yoshida T, Delafontaine P, Chandrasekar B
J Mol Cell Cardiol. 2011
PubMed ID: 21376054
NADPH oxidase is involved in post-ischemic brain inflammation.
Chen H, Kim GS, Okami N, Narasimhan P, Chan PH
Neurobiol Dis. 2011
PubMed ID: 21303700
Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels.
Rowlands DJ, Islam MN, Das SR, Huertas A, Quadri SK, Horiuchi K, Inamdar N, Emin MT, Lindert J, Ten VS, Bhattacharya S, Bhattacharya J
J Clin Invest. 2011
PubMed ID: 21519143
Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR.
Briones AM, Tabet F, Callera GE, Montezano AC, Yogi A, He Y, Quinn MT, Salaices M, Touyz RM
J Am Soc Hypertens. 2011
PubMed ID: 21419746
Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.
von Bargen K, Wohlmann J, Taylor GA, Utermöhlen O, Haas A
Infect Immun. 2011
PubMed ID: 21383050
Analysis of murine genetic predisposition to pneumococcal infection reveals a critical role of alveolar macrophages in maintaining the sterility of the lower respiratory tract.
Sun K, Gan Y, Metzger DW
Infect Immun. 2011
PubMed ID: 21321074
Role of neutrophils and NADPH phagocyte oxidase in host defense against respiratory infection with virulent Francisella tularensis in mice.
KuoLee R, Harris G, Conlan JW, Chen W
Microbes Infect. 2011
PubMed ID: 21277990
Monocarboxylate transporter-1 is required for cell death in mouse chondrocytic ATDC5 cells exposed to interleukin-1beta via late phase activation of nuclear factor kappaB and expression of phagocyte-type NADPH oxidase.
Yoshimura K, Miyamoto Y, Yasuhara R, Maruyama T, Akiyama T, Yamada A, Takami M, Suzawa T, Tsunawaki S, Tachikawa T, Baba K, Kamijo R
J Biol Chem. 2011
PubMed ID: 21372137
Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis.
Chatterjee S, Lardinois O, Bhattacharjee S, Tucker J, Corbett J, Deterding L, Ehrenshaft M, G Bonini M, Mason RP
Free Radic Biol Med. 2011
PubMed ID: 21215311
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4.
Spencer NY, Yan Z, Boudreau RL, Zhang Y, Luo M, Li Q, Tian X, Shah AM, Davisson RL, Davidson B, Banfi B, Engelhardt JF
J Biol Chem. 2011
PubMed ID: 21212270
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS).
Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM
J Exp Med. 2011
PubMed ID: 21282379
Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease.
Bustamante J, Arias AA, Vogt G, Picard C, Galicia LB, Prando C, Grant AV, Marchal CC, Hubeau M, Chapgier A, de Beaucoudrey L, Puel A, Feinberg J, Valinetz E, Jannière L, Besse C, Boland A, Brisseau JM, Blanche S, Lortholary O, Fieschi C, Emile JF, Boisson-Dupuis S, Al-Muhsen S, Woda B, Newburger PE, Condino-Neto A, Dinauer MC, Abel L, Casanova JL
Nat Immunol. 2011
PubMed ID: 21278736
GCN5 regulates the superoxide-generating system in leukocytes via controlling gp91-phox gene expression.
Kikuchi H, Kuribayashi F, Kiwaki N, Takami Y, Nakayama T
J Immunol. 2011
PubMed ID: 21278346
α1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation.
Schuhmacher S, Foretz M, Knorr M, Jansen T, Hortmann M, Wenzel P, Oelze M, Kleschyov AL, Daiber A, Keaney JF, Wegener G, Lackner K, Münzel T, Viollet B, Schulz E
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21205985
Atrial myocardial nox2 containing NADPH oxidase activity contribution to oxidative stress in mitral regurgitation: potential mechanism for atrial remodeling.
Chang JP, Chen MC, Liu WH, Yang CH, Chen CJ, Chen YL, Pan KL, Tsai TH, Chang HW
Cardiovasc Pathol. 2011
PubMed ID: 20080418
Human leukocytes kill Aspergillus nidulans by reactive oxygen species-independent mechanisms.
Henriet SS, Hermans PW, Verweij PE, Simonetti E, Holland SM, Sugui JA, Kwon-Chung KJ, Warris A
Infect Immun. 2011
PubMed ID: 21078850
Inherited human gp91phox deficiency is associated with impaired isoprostane formation and platelet dysfunction.
Pignatelli P, Carnevale R, Di Santo S, Bartimoccia S, Sanguigni V, Lenti L, Finocchi A, Mendolicchio L, Soresina AR, Plebani A, Violi F
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21071703
HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.
Gao HM, Zhou H, Zhang F, Wilson BC, Kam W, Hong JS
J Neurosci. 2011
PubMed ID: 21248133
Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation.
Zhang HS, Sang WW, Ruan Z, Wang YO
Arch Biochem Biophys. 2011
PubMed ID: 21029719
Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.
Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M
PLoS One. 2011
PubMed ID: 21731762
NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species.
Hahn NE, Meischl C, Wijnker PJ, Musters RJ, Fornerod M, Janssen HW, Paulus WJ, van Rossum AC, Niessen HW, Krijnen PA
Cell Physiol Biochem. 2011
PubMed ID: 21691064
Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea.
Nair D, Dayyat EA, Zhang SX, Wang Y, Gozal D
PLoS One. 2011
PubMed ID: 21625437
Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation.
Vlahos R, Stambas J, Bozinovski S, Broughton BR, Drummond GR, Selemidis S
PLoS Pathog. 2011
PubMed ID: 21304882
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Adenosine A(2A) receptor activation limits chronic granulomatous disease-induced hyperinflammation.
Chehata VJ, Domeier PP, Weilnau JN, Lappas CM
Cell Immunol. 2011
PubMed ID: 21130984
Characterization of superoxide overproduction by the D-Loop(Nox4)-Nox2 cytochrome b(558) in phagocytes-Differential sensitivity to calcium and phosphorylation events.
Carrichon L, Picciocchi A, Debeurme F, Defendi F, Beaumel S, Jesaitis AJ, Dagher MC, Stasia MJ
Biochim Biophys Acta. 2011
PubMed ID: 20708598
High salt intake delayed angiotensin II-induced hypertension in mice with a genetic variant of NADPH oxidase.
Haque MZ, Majid DS
Am J Hypertens. 2011
PubMed ID: 20706193
Pro-inflammatory effects of interleukin-17A on vascular smooth muscle cells involve NAD(P)H- oxidase derived reactive oxygen species.
Pietrowski E, Bender B, Huppert J, White R, Luhmann HJ, Kuhlmann CR
J Vasc Res. 2011
PubMed ID: 20606471
Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation.
Kim KS, Choi HW, Yoon HE, Kim IY
J Biol Chem. 2010
PubMed ID: 20952384
Inactivation of adenosine A2A receptor attenuates basal and angiotensin II-induced ROS production by Nox2 in endothelial cells.
Thakur S, Du J, Hourani S, Ledent C, Li JM
J Biol Chem. 2010
PubMed ID: 20940302
Influence of iNOS and COX on peroxiredoxin gene expression in primary macrophages.
Bast A, Erttmann SF, Walther R, Steinmetz I
Free Radic Biol Med. 2010
PubMed ID: 20869433
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis.
Li G, Scull C, Ozcan L, Tabas I
J Cell Biol. 2010
PubMed ID: 21135141
Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo.
Munks MW, McKee AS, Macleod MK, Powell RL, Degen JL, Reisdorph NA, Kappler JW, Marrack P
Blood. 2010
PubMed ID: 20876456
Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice.
Xue X, Pech NK, Shelley WC, Srour EF, Yoder MC, Dinauer MC
Blood. 2010
PubMed ID: 20813896
Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells.
Rao Malla R, Raghu H, Rao JS
Int J Oncol. 2010
PubMed ID: 21042717
Foot pad skin biopsy in mouse models of hereditary neuropathy.
Dacci P, Dina G, Cerri F, Previtali SC, Lopez ID, Lauria G, Feltri ML, Bolino A, Comi G, Wrabetz L, Quattrini A
Glia. 2010
PubMed ID: 20878767
The many roles of NOX2 NADPH oxidase-derived ROS in immunity.
Lam GY, Huang J, Brumell JH
Semin Immunopathol. 2010
PubMed ID: 20803017
PPARγ activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease.
Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL
Blood. 2010
PubMed ID: 20693431
Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy.
Zhao Y, McLaughlin D, Robinson E, Harvey AP, Hookham MB, Shah AM, McDermott BJ, Grieve DJ
Cancer Res. 2010
PubMed ID: 20884632
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I
Cell Metab. 2010
PubMed ID: 21035758
Atorvastatin inhibits oxidative stress via adiponectin-mediated NADPH oxidase down-regulation in hypercholesterolemic patients.
Carnevale R, Pignatelli P, Di Santo S, Bartimoccia S, Sanguigni V, Napoleone L, Tanzilli G, Basili S, Violi F
Atherosclerosis. 2010
PubMed ID: 20832062
Determination of the deletion breakpoints in two patients with contiguous gene syndrome encompassing CYBB gene.
Yamada M, Arai T, Oishi T, Hatano N, Kobayashi I, Kubota M, Suzuki N, Yoda M, Kawamura N, Ariga T
Eur J Med Genet. 2010
PubMed ID: 20813210
Regulation of NADPH oxidase activity in phagocytes: relationship between FAD/NADPH binding and oxidase complex assembly.
Debeurme F, Picciocchi A, Dagher MC, Grunwald D, Beaumel S, Fieschi F, Stasia MJ
J Biol Chem. 2010
PubMed ID: 20724480
Hematologically important mutations: X-linked chronic granulomatous disease (third update).
Roos D, Kuhns DB, Maddalena A, Roesler J, Lopez JA, Ariga T, Avcin T, de Boer M, Bustamante J, Condino-Neto A, Di Matteo G, He J, Hill HR, Holland SM, Kannengiesser C, Köker MY, Kondratenko I, van Leeuwen K, Malech HL, Marodi L, Nunoi H, Stasia MJ, Ventura AM, Witwer CT, Wolach B, Gallin JI
Blood Cells Mol Dis. 2010
PubMed ID: 20729109
Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species.
Kraaij MD, Savage ND, van der Kooij SW, Koekkoek K, Wang J, van den Berg JM, Ottenhoff TH, Kuijpers TW, Holmdahl R, van Kooten C, Gelderman KA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20861446
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.
Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C
Nat Immunol. 2010
PubMed ID: 20818396
Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner.
Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL
J Immunol. 2010
PubMed ID: 20805415
Reduced nicotinamide adenine dinucleotide phosphate oxidase 2 plays a key role in stellate cell activation and liver fibrogenesis in vivo.
Jiang JX, Venugopal S, Serizawa N, Chen X, Scott F, Li Y, Adamson R, Devaraj S, Shah V, Gershwin ME, Friedman SL, Török NJ
Gastroenterology. 2010
PubMed ID: 20685364
NADPH oxidase-derived superoxide impairs calcium transients and contraction in aged murine ventricular myocytes.
Rueckschloss U, Villmow M, Klöckner U
Exp Gerontol. 2010
PubMed ID: 20493939
Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40.
Yu G, Bolon M, Laird DW, Tyml K
Free Radic Biol Med. 2010
PubMed ID: 20541007
Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease.
Meissner F, Seger RA, Moshous D, Fischer A, Reichenbach J, Zychlinsky A
Blood. 2010
PubMed ID: 20495074
Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants.
Yang CW, Strong BS, Miller MJ, Unanue ER
J Immunol. 2010
PubMed ID: 20679530
Involvement of RAGE, NADPH oxidase, and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells.
Sangle GV, Zhao R, Mizuno TM, Shen GX
Endocrinology. 2010
PubMed ID: 20630999
The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses.
Sorce S, Schiavone S, Tucci P, Colaianna M, Jaquet V, Cuomo V, Dubois-Dauphin M, Trabace L, Krause KH
J Neurosci. 2010
PubMed ID: 20739552
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.
Kim D, You B, Jo EK, Han SK, Simon MI, Lee SJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20679217
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
Kong X, Thimmulappa R, Kombairaju P, Biswal S
J Immunol. 2010
PubMed ID: 20511556
gp-91 mediates histone deacetylase inhibition-induced cardioprotection.
Zhao TC, Zhang LX, Cheng G, Liu JT
Biochim Biophys Acta. 2010
PubMed ID: 20433879
Molecular basis of autosomal recessive chronic granulomatous disease in iran.
Teimourian S, de Boer M, Roos D
J Clin Immunol. 2010
PubMed ID: 20407811
iPLA2, a novel determinant in Ca2+- and phosphorylation-dependent S100A8/A9 regulated NOX2 activity.
Schenten V, Bréchard S, Plançon S, Melchior C, Frippiat JP, Tschirhart EJ
Biochim Biophys Acta. 2010
PubMed ID: 20219570
Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide.
Brait VH, Jackman KA, Walduck AK, Selemidis S, Diep H, Mast AE, Guida E, Broughton BR, Drummond GR, Sobey CG
J Cereb Blood Flow Metab. 2010
PubMed ID: 20145655
NOX activity is increased in mild cognitive impairment.
Bruce-Keller AJ, Gupta S, Parrino TE, Knight AG, Ebenezer PJ, Weidner AM, LeVine H, Keller JN, Markesbery WR
Antioxid Redox Signal. 2010
PubMed ID: 19929442
NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes.
Rybicka JM, Balce DR, Khan MF, Krohn RM, Yates RM
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20498052
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.
Martinon F, Chen X, Lee AH, Glimcher LH
Nat Immunol. 2010
PubMed ID: 20351694
Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body.
He L, Liu X, Chen J, Dinger B, Stensaas L, Fidone S
J Appl Physiol. 2010
PubMed ID: 20185631
Protection of podocytes from hyperhomocysteinemia-induced injury by deletion of the gp91phox gene.
Zhang C, Hu JJ, Xia M, Boini KM, Brimson CA, Laperle LA, Li PL
Free Radic Biol Med. 2010
PubMed ID: 20116427
Oxidative stress mediates nephropathy in type Ia glycogen storage disease.
Yiu WH, Mead PA, Jun HS, Mansfield BC, Chou JY
Lab Invest. 2010
PubMed ID: 20195241
Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia.
Miller AA, De Silva TM, Judkins CP, Diep H, Drummond GR, Sobey CG
Stroke. 2010
PubMed ID: 20167907
Rac1-mediated NADPH oxidase release of O2- regulates epithelial sodium channel activity in the alveolar epithelium.
Takemura Y, Goodson P, Bao HF, Jain L, Helms MN
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 20097736
Involvement of NADPH oxidase in age-associated cardiac remodeling.
Wang M, Zhang J, Walker SJ, Dworakowski R, Lakatta EG, Shah AM
J Mol Cell Cardiol. 2010
PubMed ID: 20079746
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway.
El Jamali A, Valente AJ, Clark RA
Free Radic Biol Med. 2010
PubMed ID: 20043988
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
NOX2 is the primary source of angiotensin II-induced superoxide in the macula densa.
Fu Y, Zhang R, Lu D, Liu H, Chandrashekar K, Juncos LA, Liu R
Am J Physiol Regul Integr Comp Physiol. 2010
PubMed ID: 20053956
Intrarenal artery superoxide is mainly NADPH oxidase-derived and modulates endothelium-dependent dilation in elderly patients.
Schlüter T, Zimmermann U, Protzel C, Miehe B, Klebingat KJ, Rettig R, Grisk O
Cardiovasc Res. 2010
PubMed ID: 19843513
Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells.
Fraszczak J, Trad M, Janikashvili N, Cathelin D, Lakomy D, Granci V, Morizot A, Audia S, Micheau O, Lagrost L, Katsanis E, Solary E, Larmonier N, Bonnotte B
J Immunol. 2010
PubMed ID: 20089706
Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization.
von Löhneysen K, Noack D, Wood MR, Friedman JS, Knaus UG
Mol Cell Biol. 2010
PubMed ID: 19995913
Atorvastatin inhibits gp91phox circulating levels in patients with hypercholesterolemia.
Pignatelli P, Carnevale R, Cangemi R, Loffredo L, Sanguigni V, Stefanutti C, Basili S, Violi F
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 19965781
Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration.
Kim SY, Lee JG, Cho WS, Cho KH, Sakong J, Kim JR, Chin BR, Baek SH
Immunol Cell Biol. 2010
PubMed ID: 19935767
Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2.
Xia M, Li G, Ma J, Ling W
J Thromb Haemost. 2010
PubMed ID: 19895673
Ischemia-activated microglia induces neuronal injury via activation of gp91phox NADPH oxidase.
Hur J, Lee P, Kim MJ, Kim Y, Cho YW
Biochem Biophys Res Commun. 2010
PubMed ID: 20036216
Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II.
Mokni W, Keravis T, Etienne-Selloum N, Walter A, Kane MO, Schini-Kerth VB, Lugnier C
PLoS One. 2010
PubMed ID: 21151982
Molecular and functional characterization of Hv1 proton channel in human granulocytes.
Petheo GL, Orient A, Baráth M, Kovács I, Réthi B, Lányi A, Rajki A, Rajnavölgyi E, Geiszt M
PLoS One. 2010
PubMed ID: 21124855
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration.
Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K, Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A, Becker L, Gailus-Durner V, Fuchs H, Klopstock T, de Angelis MH, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HH
PLoS Biol. 2010
PubMed ID: 20877715
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.
Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
J Neuroinflammation. 2010
PubMed ID: 20659322
Cancer resistance of SR/CR mice in the genetic knockout backgrounds of leukocyte effector mechanisms: determinations for functional requirements.
Sanders AM, Stehle JR, Blanks MJ, Riedlinger G, Kim-Shapiro JW, Monjazeb AM, Adams JM, Willingham MC, Cui Z
BMC Cancer. 2010
PubMed ID: 20356394
NADPH oxidase limits innate immune responses in the lungs in mice.
Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS
PLoS One. 2010
PubMed ID: 20300512
NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts.
Bondi CD, Manickam N, Lee DY, Block K, Gorin Y, Abboud HE, Barnes JL
J Am Soc Nephrol. 2010
PubMed ID: 19926889
Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice.
Judkins CP, Diep H, Broughton BR, Mast AE, Hooker EU, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummond GR
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 19837950
Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase.
Loot AE, Schreiber JG, Fisslthaler B, Fleming I
J Exp Med. 2009
PubMed ID: 19934023
BCR-induced superoxide negatively regulates B-cell proliferation and T-cell-independent type 2 Ab responses.
Richards SM, Clark EA
Eur J Immunol. 2009
PubMed ID: 19877015
Identification of deletion carriers in X-linked chronic granulomatous disease by real-time PCR.
Chiriaco M, Di Matteo G, Sinibaldi C, Giardina E, Nardone AM, Folgori L, D'Argenio P, Rossi P, Finocchi A
Genet Test Mol Biomarkers. 2009
PubMed ID: 19839755
Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane.
Oakley FD, Smith RL, Engelhardt JF
J Biol Chem. 2009
PubMed ID: 19801678
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.
Carnesecchi S, Deffert C, Pagano A, Garrido-Urbani S, Métrailler-Ruchonnet I, Schäppi M, Donati Y, Matthay MA, Krause KH, Barazzone Argiroffo C
Am J Respir Crit Care Med. 2009
PubMed ID: 19661248
Effects of acute and chronic endurance exercise on intracellular nitric oxide in putative endothelial progenitor cells: role of NAPDH oxidase.
Jenkins NT, Witkowski S, Spangenburg EE, Hagberg JM
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19717732
Neutrophil antimicrobial defense against Staphylococcus aureus is mediated by phagolysosomal but not extracellular trap-associated cathelicidin.
Jann NJ, Schmaler M, Kristian SA, Radek KA, Gallo RL, Nizet V, Peschel A, Landmann R
J Leukoc Biol. 2009
PubMed ID: 19638500
Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study.
Violi F, Sanguigni V, Carnevale R, Plebani A, Rossi P, Finocchi A, Pignata C, De Mattia D, Martire B, Pietrogrande MC, Martino S, Gambineri E, Soresina AR, Pignatelli P, Martino F, Basili S, Loffredo L
Circulation. 2009
PubMed ID: 19805647
New p22-phox monoclonal antibodies: identification of a conformational probe for cytochrome b 558.
Campion Y, Jesaitis AJ, Nguyen MV, Grichine A, Herenger Y, Baillet A, Berthier S, Morel F, Paclet MH
J Innate Immun. 2009
PubMed ID: 20375611
Innate immune cells induce hemorrhage in tumors during thrombocytopenia.
Ho-Tin-Noé B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD
Am J Pathol. 2009
PubMed ID: 19729481
Neutrophil-mediated lung permeability and host defense proteins.
Kantrow SP, Shen Z, Jagneaux T, Zhang P, Nelson S
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19648288
Nox2-containing NADPH oxidase deficiency confers protection from hindlimb ischemia in conditions of increased oxidative stress.
Haddad P, Dussault S, Groleau J, Turgeon J, Michaud SE, Ménard C, Perez G, Maingrette F, Rivard A
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19574557
Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis.
Chatterjee S, Lardinois O, Bonini MG, Bhattacharjee S, Stadler K, Corbett J, Deterding LJ, Tomer KB, Kadiiska M, Mason RP
J Immunol. 2009
PubMed ID: 19717511
NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells.
Schröder K, Kohnen A, Aicher A, Liehn EA, Büchse T, Stein S, Weber C, Dimmeler S, Brandes RP
Circ Res. 2009
PubMed ID: 19679834
NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxin-primed macrophages.
Moore SF, MacKenzie AB
J Immunol. 2009
PubMed ID: 19696433
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy.
McCrann DJ, Eliades A, Makitalo M, Matsuno K, Ravid K
Blood. 2009
PubMed ID: 19471020
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Zhang W, Baban B, Rojas M, Tofigh S, Virmani SK, Patel C, Behzadian MA, Romero MJ, Caldwell RW, Caldwell RB
Am J Pathol. 2009
PubMed ID: 19590038
Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemia.
Zhu H, Shan L, Peng T
J Mol Cell Cardiol. 2009
PubMed ID: 19450605
NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival.
Peshavariya H, Dusting GJ, Jiang F, Halmos LR, Sobey CG, Drummond GR, Selemidis S
Naunyn Schmiedebergs Arch Pharmacol. 2009
PubMed ID: 19337723
Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism.
Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, Geuking MB, Beutler B, Tedder TF, Hardt WD, Bercik P, Verdu EF, McCoy KD, Macpherson AJ
Science. 2009
PubMed ID: 19644121
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Receptor activator of nuclear factor-kappaB ligand-induced mouse osteoclast differentiation is associated with switching between NADPH oxidase homologues.
Sasaki H, Yamamoto H, Tominaga K, Masuda K, Kawai T, Teshima-Kondo S, Matsuno K, Yabe-Nishimura C, Rokutan K
Free Radic Biol Med. 2009
PubMed ID: 19409483
Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis.
Purushothaman D, Sarin A
J Exp Med. 2009
PubMed ID: 19546249
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.
Chen H, Song YS, Chan PH
J Cereb Blood Flow Metab. 2009
PubMed ID: 19417757
Involvement of NADPH oxidase in oxidized LDL-induced upregulation of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells.
Zhao R, Ma X, Xie X, Shen GX
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19401454
Molecular characterization of a large cohort of patients with Chronic Granulomatous Disease and identification of novel CYBB mutations: an Italian multicenter study.
Di Matteo G, Giordani L, Finocchi A, Ventura A, Chiriaco M, Blancato J, Sinibaldi C, Plebani A, Soresina A, Pignata C, Dellepiane RM, Trizzino A, Cossu F, Rondelli R, Rossi P, De Mattia D, Martire B, IPINET (Italian Network for Primary Immunodeficiencies)
Mol Immunol. 2009
PubMed ID: 19410294
Silencing of host cell CYBB gene expression by the nuclear effector AnkA of the intracellular pathogen Anaplasma phagocytophilum.
Garcia-Garcia JC, Rennoll-Bankert KE, Pelly S, Milstone AM, Dumler JS
Infect Immun. 2009
PubMed ID: 19307214
Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.
Diebold I, Djordjevic T, Petry A, Hatzelmann A, Tenor H, Hess J, Görlach A
Circ Res. 2009
PubMed ID: 19390057
NADPH oxidase contributes to conversion of cardiac myocytes to a proinflammatory phenotype in sepsis.
Wu J, Xu H, Yang M, Martin CM, Kvietys PR, Rui T
Free Radic Biol Med. 2009
PubMed ID: 19249346
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells.
Corzo CA, Cotter MJ, Cheng P, Cheng F, Kusmartsev S, Sotomayor E, Padhya T, McCaffrey TV, McCaffrey JC, Gabrilovich DI
J Immunol. 2009
PubMed ID: 19380816
Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes.
Sugimura Y, Murase T, Oyama K, Uchida A, Sato N, Hayasaka S, Kano Y, Takagishi Y, Hayashi Y, Oiso Y, Murata Y
Diabetologia. 2009
PubMed ID: 19283362
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice.
Nisbet RE, Graves AS, Kleinhenz DJ, Rupnow HL, Reed AL, Fan TH, Mitchell PO, Sutliff RL, Hart CM
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18952568
Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase.
Zhao W, Zhao D, Yan R, Sun Y
Cardiovasc Pathol. 2009
PubMed ID: 18402834
The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells.
Savina A, Peres A, Cebrian I, Carmo N, Moita C, Hacohen N, Moita LF, Amigorena S
Immunity. 2009
PubMed ID: 19328020
Insulin-induced NADPH oxidase activation promotes proliferation and matrix metalloproteinase activation in monocytes/macrophages.
San José G, Bidegain J, Robador PA, Díez J, Fortuño A, Zalba G
Free Radic Biol Med. 2009
PubMed ID: 19439231
NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia.
Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR
J Neurosci. 2009
PubMed ID: 19369559
Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species.
De Silva TM, Broughton BR, Drummond GR, Sobey CG, Miller AA
Stroke. 2009
PubMed ID: 19211495
Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction.
Gupte SA, Kaminski PM, George S, Kouznestova L, Olson SC, Mathew R, Hintze TH, Wolin MS
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19168729
OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca2+ entry.
Bréchard S, Salsmann A, Tschirhart EJ
J Leukoc Biol. 2009
PubMed ID: 19118104
Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells.
Pendyala S, Gorshkova IA, Usatyuk PV, He D, Pennathur A, Lambeth JD, Thannickal VJ, Natarajan V
Antioxid Redox Signal. 2009
PubMed ID: 18783311
NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression.
Yang CS, Shin DM, Kim KH, Lee ZW, Lee CH, Park SG, Bae YS, Jo EK
J Immunol. 2009
PubMed ID: 19265148
Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo.
Zhang WJ, Wei H, Frei B
Free Radic Biol Med. 2009
PubMed ID: 19124074
A novel point mutation in the CYBB gene promoter leading to a rare X minus chronic granulomatous disease variant--impact on the microbicidal activity of neutrophils.
Defendi F, Decleva E, Martel C, Dri P, Stasia MJ
Biochim Biophys Acta. 2009
PubMed ID: 19708127
Nonresolving inflammation in gp91phox-/- mice, a model of human chronic granulomatous disease, has lower adenosine and cyclic adenosine 5'-monophosphate.
Rajakariar R, Newson J, Jackson EK, Sawmynaden P, Smith A, Rahman F, Yaqoob MM, Gilroy DW
J Immunol. 2009
PubMed ID: 19234224
Isoforms and functions of NAD(P)H oxidase at the macula densa.
Zhang R, Harding P, Garvin JL, Juncos R, Peterson E, Juncos LA, Liu R
Hypertension. 2009
PubMed ID: 19204183
Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth.
Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19151256
Role of NADPH phagocyte oxidase in host defense against acute respiratory Acinetobacter baumannii infection in mice.
Qiu H, Kuolee R, Harris G, Chen W
Infect Immun. 2009
PubMed ID: 19103777
Nox2-containing NADPH oxidase and xanthine oxidase are sources of superoxide in mouse trachea.
Westover A, Harrison CB, Selemidis S
Clin Exp Pharmacol Physiol. 2009
PubMed ID: 19076165
First report of clinical, functional, and molecular investigation of chronic granulomatous disease in nine Jordanian families.
Bakri FG, Martel C, Khuri-Bulos N, Mahafzah A, El-Khateeb MS, Al-Wahadneh AM, Hayajneh WA, Hamamy HA, Maquet E, Molin M, Stasia MJ
J Clin Immunol. 2009
PubMed ID: 18773283
Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4.
Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL
Blood. 2009
PubMed ID: 18952895
NMDA receptor activation increases free radical production through nitric oxide and NOX2.
Girouard H, Wang G, Gallo EF, Anrather J, Zhou P, Pickel VM, Iadecola C
J Neurosci. 2009
PubMed ID: 19244529
Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes.
Casbon AJ, Allen LA, Dunn KW, Dinauer MC
J Immunol. 2009
PubMed ID: 19201887
Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.
Maehara Y, Miyano K, Sumimoto H
Biochem Biophys Res Commun. 2009
PubMed ID: 19116138
MHC molecules and microbial antigen processing in phagosomes.
Ramachandra L, Simmons D, Harding CV
Curr Opin Immunol. 2009
PubMed ID: 19217269
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
J Proteome Res. 2009
PubMed ID: 19159218
Suppression of retinal peroxisome proliferator-activated receptor gamma in experimental diabetes and oxygen-induced retinopathy: role of NADPH oxidase.
Tawfik A, Sanders T, Kahook K, Akeel S, Elmarakby A, Al-Shabrawey M
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 18806296
Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2.
Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI
Circ Res. 2009
PubMed ID: 19096031
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS
Genome Biol. 2009
PubMed ID: 19799774
Malarial hemozoin is a Nalp3 inflammasome activating danger signal.
Dostert C, Guarda G, Romero JF, Menu P, Gross O, Tardivel A, Suva ML, Stehle JC, Kopf M, Stamenkovic I, Corradin G, Tschopp J
PLoS One. 2009
PubMed ID: 19652710
The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing.
Cutz E, Pan J, Yeger H
Adv Exp Med Biol. 2009
PubMed ID: 19536508
IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase.
Dugan LL, Ali SS, Shekhtman G, Roberts AJ, Lucero J, Quick KL, Behrens MM
PLoS One. 2009
PubMed ID: 19436757
NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2.
Miller AA, Drummond GR, De Silva TM, Mast AE, Hickey H, Williams JP, Broughton BR, Sobey CG
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19028794
Role of NOX2 in the regulation of afferent arteriole responsiveness.
Carlström M, Lai EY, Ma Z, Patzak A, Brown RD, Persson AE
Am J Physiol Regul Integr Comp Physiol. 2009
PubMed ID: 18987286
Interleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia.
Behrens MM, Ali SS, Dugan LL
J Neurosci. 2008
PubMed ID: 19091984
Alveolar macrophages from septic mice promote polymorphonuclear leukocyte transendothelial migration via an endothelial cell Src kinase/NADPH oxidase pathway.
Wang Z, Rui T, Yang M, Valiyeva F, Kvietys PR
J Immunol. 2008
PubMed ID: 19050294
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.
Anderson KE, Boyle KB, Davidson K, Chessa TA, Kulkarni S, Jarvis GE, Sindrilaru A, Scharffetter-Kochanek K, Rausch O, Stephens LR, Hawkins PT
Blood. 2008
PubMed ID: 18755982
Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide.
Straub AC, Clark KA, Ross MA, Chandra AG, Li S, Gao X, Pagano PJ, Stolz DB, Barchowsky A
J Clin Invest. 2008
PubMed ID: 19033667
NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells.
Mantegazza AR, Savina A, Vermeulen M, Pérez L, Geffner J, Hermine O, Rosenzweig SD, Faure F, Amigorena S
Blood. 2008
PubMed ID: 18682599
NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A.
Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin HS, Leslie C, Henson PM, Murphy RC, Bratton DL
J Biol Chem. 2008
PubMed ID: 18824544
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.
Chéret C, Gervais A, Lelli A, Colin C, Amar L, Ravassard P, Mallet J, Cumano A, Krause KH, Mallat M
J Neurosci. 2008
PubMed ID: 19005069
X-linked chronic granulomatous disease secondary to skewed X chromosome inactivation in a female with a novel CYBB mutation and late presentation.
Lewis EM, Singla M, Sergeant S, Koty PP, McPhail LC
Clin Immunol. 2008
PubMed ID: 18774749
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Caveolae are an essential component of the pathway for endothelial cell signaling associated with abrupt reduction of shear stress.
Milovanova T, Chatterjee S, Hawkins BJ, Hong N, Sorokina EM, Debolt K, Moore JS, Madesh M, Fisher AB
Biochim Biophys Acta. 2008
PubMed ID: 18573285
Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein.
Cheng P, Corzo CA, Luetteke N, Yu B, Nagaraj S, Bui MM, Ortiz M, Nacken W, Sorg C, Vogl T, Roth J, Gabrilovich DI
J Exp Med. 2008
PubMed ID: 18809714
The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation.
Kim JH, Na HJ, Kim CK, Kim JY, Ha KS, Lee H, Chung HT, Kwon HJ, Kwon YG, Kim YM
Free Radic Biol Med. 2008
PubMed ID: 18620044
Reduced renal responses to nitric oxide synthase inhibition in mice lacking the gene for gp91phox subunit of NAD(P)H oxidase.
Haque MZ, Majid DS
Am J Physiol Renal Physiol. 2008
PubMed ID: 18596078
Molecular epidemiology of chronic granulomatous disease in a series of 80 kindreds: identification of 31 novel mutations.
Kannengiesser C, Gérard B, El Benna J, Henri D, Kroviarski Y, Chollet-Martin S, Gougerot-Pocidalo MA, Elbim C, Grandchamp B
Hum Mutat. 2008
PubMed ID: 18546332
Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes.
Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE
Toxicol Appl Pharmacol. 2008
PubMed ID: 18534653
Essential role of nuclear factor-kappaB for NADPH oxidase activity in normal and anhidrotic ectodermal dysplasia leukocytes.
Luengo-Blanco M, Prando C, Bustamante J, Aragão-Filho WC, Pereira PV, Rehder J, Padden C, Casanova JL, Newburger PE, Condino-Neto A
Blood. 2008
PubMed ID: 18523147
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.
Meissner F, Molawi K, Zychlinsky A
Nat Immunol. 2008
PubMed ID: 18604212
Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis.
Stadler K, Bonini MG, Dallas S, Duma D, Mason RP, Kadiiska MB
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18559982
Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia.
Urao N, Inomata H, Razvi M, Kim HW, Wary K, McKinney R, Fukai T, Ushio-Fukai M
Circ Res. 2008
PubMed ID: 18583711
Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia.
Qian L, Wei SJ, Zhang D, Hu X, Xu Z, Wilson B, El-Benna J, Hong JS, Flood PM
J Immunol. 2008
PubMed ID: 18566433
Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.
Kim HS, Loughran PA, Rao J, Billiar TR, Zuckerbraun BS
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18497334
Nox4 and nox2 NADPH oxidases mediate distinct cellular redox signaling responses to agonist stimulation.
Anilkumar N, Weber R, Zhang M, Brewer A, Shah AM
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18467643
Role of NADPH oxidase in retinal vascular inflammation.
Al-Shabrawey M, Rojas M, Sanders T, Behzadian A, El-Remessy A, Bartoli M, Parpia AK, Liou G, Caldwell RB
Invest Ophthalmol Vis Sci. 2008
PubMed ID: 18378574
CD4+ T lymphocytes mediate hypercholesterolemia-induced endothelial dysfunction via a NAD(P)H oxidase-dependent mechanism.
Wolfort RM, Stokes KY, Granger DN
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18408127
Dual role of NOX2 in respiratory syncytial virus- and sendai virus-induced activation of NF-kappaB in airway epithelial cells.
Fink K, Duval A, Martel A, Soucy-Faulkner A, Grandvaux N
J Immunol. 2008
PubMed ID: 18453612
Reduced nicotinamide adenine dinucleotide phosphate oxidase-independent resistance to Aspergillus fumigatus in alveolar macrophages.
Cornish EJ, Hurtgen BJ, McInnerney K, Burritt NL, Taylor RM, Jarvis JN, Wang SY, Burritt JB
J Immunol. 2008
PubMed ID: 18453606
Nox-generated ROS modulate glucose uptake in a leukaemic cell line.
Prata C, Maraldi T, Fiorentini D, Zambonin L, Hakim G, Landi L
Free Radic Res. 2008
PubMed ID: 18473264
Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart.
Spurney CF, Knoblach S, Pistilli EE, Nagaraju K, Martin GR, Hoffman EP
Neuromuscul Disord. 2008
PubMed ID: 18440230
Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice.
Yao H, Edirisinghe I, Yang SR, Rajendrasozhan S, Kode A, Caito S, Adenuga D, Rahman I
Am J Pathol. 2008
PubMed ID: 18403597
Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury.
Li Q, Zhang Y, Marden JJ, Banfi B, Engelhardt JF
Biochem J. 2008
PubMed ID: 18397177
Role of gp91phox-containing NADPH oxidase in left ventricular remodeling induced by intermittent hypoxic stress.
Hayashi T, Yamashita C, Matsumoto C, Kwak CJ, Fujii K, Hirata T, Miyamura M, Mori T, Ukimura A, Okada Y, Matsumura Y, Kitaura Y
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18326795
CYBB, an NADPH-oxidase gene: restricted diversity in humans and evidence for differential long-term purifying selection on transmembrane and cytosolic domains.
Tarazona-Santos E, Bernig T, Burdett L, Magalhaes WC, Fabbri C, Liao J, Redondo RA, Welch R, Yeager M, Chanock SJ
Hum Mutat. 2008
PubMed ID: 18278805
Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia.
Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MK, Dockrell DH
Am J Respir Crit Care Med. 2008
PubMed ID: 18202350
Modelling within-host spatiotemporal dynamics of invasive bacterial disease.
Grant AJ, Restif O, McKinley TJ, Sheppard M, Maskell DJ, Mastroeni P
PLoS Biol. 2008
PubMed ID: 18399718
Th17 development and autoimmune arthritis in the absence of reactive oxygen species.
George-Chandy A, Nordström I, Nygren E, Jonsson IM, Postigo J, Collins LV, Eriksson K
Eur J Immunol. 2008
PubMed ID: 18383034
Characterization of a candidate locus for malaria susceptibility in human populations: a (TA)n microsatellite in the promoter region of the CYBB gene, the gp91 phox subunit of the NADPH oxidase.
Soares-Souza GB, Tarazona-Santos E, Chanock SJ
Int J Immunogenet. 2008
PubMed ID: 18321306
A reactive oxygen species-mediated component in neurogenic vasodilatation.
Starr A, Graepel R, Keeble J, Schmidhuber S, Clark N, Grant A, Shah AM, Brain SD
Cardiovasc Res. 2008
PubMed ID: 18203709
Branched fungal beta-glucan causes hyperinflammation and necrosis in phagocyte NADPH oxidase-deficient mice.
Schäppi M, Deffert C, Fiette L, Gavazzi G, Herrmann F, Belli D, Krause KH
J Pathol. 2008
PubMed ID: 18098349
Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation.
Zhu C, Lindsey S, Konieczna I, Eklund EA
J Leukoc Biol. 2008
PubMed ID: 18089853
Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion.
Kunz A, Abe T, Hochrainer K, Shimamura M, Anrather J, Racchumi G, Zhou P, Iadecola C
J Neurosci. 2008
PubMed ID: 18272685
SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model.
Harraz MM, Marden JJ, Zhou W, Zhang Y, Williams A, Sharov VS, Nelson K, Luo M, Paulson H, Schöneich C, Engelhardt JF
J Clin Invest. 2008
PubMed ID: 18219391
Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction.
Looi YH, Grieve DJ, Siva A, Walker SJ, Anilkumar N, Cave AC, Marber M, Monaghan MJ, Shah AM
Hypertension. 2008
PubMed ID: 18180403
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.
Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18202172
A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice.
Woo H, Okamoto S, Guiney D, Gunn JS, Fierer J
PLoS ONE. 2008
PubMed ID: 18270590
HIV-1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases.
Wu RF, Ma Z, Myers DP, Terada LS
J Biol Chem. 2007
PubMed ID: 17940286
Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase.
Behrens MM, Ali SS, Dao DN, Lucero J, Shekhtman G, Quick KL, Dugan LL
Science. 2007
PubMed ID: 18063801
A novel mutation of the CYBB gene resulting in severe form of X-linked chronic granulomatous disease.
Jirapongsananuruk O, Noack D, Boonchoo S, Thepthai C, Chokephaibulkit K, Visitsunthorn N, Vichyanond P, Luangwedchakarn V, Likasitwattanakul S, Piboonpocanun S
Asian Pac J Allergy Immunol. 2007
PubMed ID: 18402299
Nonsense mutations of the CYBB gene in two Thai families with X-linked chronic granulomatous disease.
Vilaiphan P, Chatchatee P, Ngamphaiboon J, Tongkobpetch S, Suphapeetiporn K, Shotelersuk V
Asian Pac J Allergy Immunol. 2007
PubMed ID: 18402298
NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.
Coffey MJ, Serezani CH, Phare SM, Flamand N, Peters-Golden M
J Leukoc Biol. 2007
PubMed ID: 17761955
Virulence of Burkholderia cepacia complex strains in gp91phox-/- mice.
Sousa SA, Ulrich M, Bragonzi A, Burke M, Worlitzsch D, Leitão JH, Meisner C, Eberl L, Sá-Correia I, Döring G
Cell Microbiol. 2007
PubMed ID: 17627623
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain.
Park L, Anrather J, Girouard H, Zhou P, Iadecola C
J Cereb Blood Flow Metab. 2007
PubMed ID: 17429347
An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.
Graham DB, Stephenson LM, Lam SK, Brim K, Lee HM, Bautista J, Gilfillan S, Akilesh S, Fujikawa K, Swat W
J Exp Med. 2007
PubMed ID: 17984307
Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner.
Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y
J Immunol. 2007
PubMed ID: 17982061
G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.
Hawkins BJ, Solt LA, Chowdhury I, Kazi AS, Abid MR, Aird WC, May MJ, Foskett JK, Madesh M
Mol Cell Biol. 2007
PubMed ID: 17724077
MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity.
Pei Z, Pang H, Qian L, Yang S, Wang T, Zhang W, Wu X, Dallas S, Wilson B, Reece JM, Miller DS, Hong JS, Block ML
Glia. 2007
PubMed ID: 17654704
Nox2 regulates endothelial cell cycle arrest and apoptosis via p21cip1 and p53.
Li JM, Fan LM, George VT, Brooks G
Free Radic Biol Med. 2007
PubMed ID: 17697942
Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice.
Liu S, Tang J, Ostrowski RP, Titova E, Monroe C, Chen W, Lo W, Martin R, Zhang JH
Can J Neurol Sci. 2007
PubMed ID: 17803037
Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice.
Rocha FJ, Schleicher U, Mattner J, Alber G, Bogdan C
Infect Immun. 2007
PubMed ID: 17517868
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.
Kawano T, Kunz A, Abe T, Girouard H, Anrather J, Zhou P, Iadecola C
J Cereb Blood Flow Metab. 2007
PubMed ID: 17293848
IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals.
Li X, McKinstry KK, Swain SL, Dalton DK
J Immunol. 2007
PubMed ID: 17617585
Platelet-associated NAD(P)H oxidase contributes to the thrombogenic phenotype induced by hypercholesterolemia.
Stokes KY, Russell JM, Jennings MH, Alexander JS, Granger DN
Free Radic Biol Med. 2007
PubMed ID: 17561090
A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils.
Wilkie RP, Vissers MC, Dragunow M, Hampton MB
Infect Immun. 2007
PubMed ID: 17438039
Contribution of different Nox homologues to cardiac remodeling in two-kidney two-clip renovascular hypertensive rats: effect of valsartan.
Wang P, Tang F, Li R, Zhang H, Chen S, Liu P, Huang H
Pharmacol Res. 2007
PubMed ID: 17324585
Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
Matsumoto T, Kobayashi T, Wachi H, Seyama Y, Kamata K
Atherosclerosis. 2007
PubMed ID: 16831440
Endothelial Nox2 overexpression potentiates vascular oxidative stress and hemodynamic response to angiotensin II: studies in endothelial-targeted Nox2 transgenic mice.
Bendall JK, Rinze R, Adlam D, Tatham AL, de Bono J, Wilson N, Volpi E, Channon KM
Circ Res. 2007
PubMed ID: 17363703
NADPH oxidase but not myeloperoxidase protects lymphopenic mice from spontaneous infections.
Ostanin DV, Barlow S, Shukla D, Grisham MB
Biochem Biophys Res Commun. 2007
PubMed ID: 17316569
NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury.
Lo W, Bravo T, Jadhav V, Titova E, Zhang JH, Tang J
Neurosci Lett. 2007
PubMed ID: 17317004
Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation.
Gao XP, Zhu X, Fu J, Liu Q, Frey RS, Malik AB
J Biol Chem. 2007
PubMed ID: 17197441
Gp91phox-containing NAD(P)H oxidase increases superoxide formation by doxorubicin and NADPH.
Deng S, Kruger A, Kleschyov AL, Kalinowski L, Daiber A, Wojnowski L
Free Radic Biol Med. 2007
PubMed ID: 17275678
Severe X-linked chronic granulomatous disease in two unrelated females.
Chollet-Martin S, Lopez A, Gaud C, Henry D, Stos B, El Benna J, Chedevile G, Gendrel D, Gougerot-Pocidalo MA, Grandchamp B, Gérard B
Eur J Pediatr. 2007
PubMed ID: 17089090
Liposome-mediated cellular delivery of active gp91(phox).
Marques B, Liguori L, Paclet MH, Villegas-Mendéz A, Rothe R, Morel F, Lenormand JL
PLoS One. 2007
PubMed ID: 17848987
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.
Kim YS, Choi DH, Block ML, Lorenzl S, Yang L, Kim YJ, Sugama S, Cho BP, Hwang O, Browne SE, Kim SY, Hong JS, Beal MF, Joh TH
FASEB J. 2007
PubMed ID: 17116747
Leu505 of Nox2 is crucial for optimal p67phox-dependent activation of the flavocytochrome b558 during phagocytic NADPH oxidase assembly.
Li XJ, Fieschi F, Paclet MH, Grunwald D, Campion Y, Gaudin P, Morel F, Stasia MJ
J Leukoc Biol. 2007
PubMed ID: 17060362
Reactive oxygen species derived from NADPH oxidase system is not essential for liver regeneration after partial hepatectomy.
Ueno S, Campbell J, Fausto N
J Surg Res. 2006
PubMed ID: 17046793
The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response.
Kurtz S, McKinnon KP, Runge MS, Ting JP, Braunstein M
Infect Immun. 2006
PubMed ID: 17030572
Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons.
Glass MJ, Huang J, Oselkin M, Tarsitano MJ, Wang G, Iadecola C, Pickel VM
Neuroscience. 2006
PubMed ID: 17027166
Analysis of human phagocyte flavocytochrome b(558) by mass spectrometry.
Taylor RM, Baniulis D, Burritt JB, Gripentrog JM, Lord CI, Riesselman MH, Maaty WS, Bothner BP, Angel TE, Dratz EA, Linton GF, Malech HL, Jesaitis AJ
J Biol Chem. 2006
PubMed ID: 17015440
Early neutrophil recruitment and aggregation in the murine lung inhibit germination of Aspergillus fumigatus Conidia.
Bonnett CR, Cornish EJ, Harmsen AG, Burritt JB
Infect Immun. 2006
PubMed ID: 16920786
Role of inducible nitric oxide synthase and NADPH oxidase in early control of Burkholderia pseudomallei infection in mice.
Breitbach K, Klocke S, Tschernig T, van Rooijen N, Baumann U, Steinmetz I
Infect Immun. 2006
PubMed ID: 17000727
Myotube depolarization generates reactive oxygen species through NAD(P)H oxidase; ROS-elicited Ca2+ stimulates ERK, CREB, early genes.
Espinosa A, Leiva A, Peña M, Müller M, Debandi A, Hidalgo C, Carrasco MA, Jaimovich E
J Cell Physiol. 2006
PubMed ID: 16897752
Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke.
Hong H, Zeng JS, Kreulen DL, Kaufman DI, Chen AF
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16766636
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons.
Qin B, Cartier L, Dubois-Dauphin M, Li B, Serrander L, Krause KH
Neurobiol Aging. 2006
PubMed ID: 16260066
In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection.
Snelgrove RJ, Edwards L, Williams AE, Rae AJ, Hussell T
J Immunol. 2006
PubMed ID: 17015737
Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity.
Zhu Y, Marchal CC, Casbon AJ, Stull N, von Löhneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, Dinauer MC
J Biol Chem. 2006
PubMed ID: 16895900
Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: involvement of the renin-angiotensin system.
Akasaki T, Ohya Y, Kuroda J, Eto K, Abe I, Sumimoto H, Iida M
Hypertens Res. 2006
PubMed ID: 17283869
Effect of immune serum and role of individual Fcgamma receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages.
Uppington H, Menager N, Boross P, Wood J, Sheppard M, Verbeek S, Mastroeni P
Immunology. 2006
PubMed ID: 16836651
NOX2 and NOX4 mediate proliferative response in endothelial cells.
Petry A, Djordjevic T, Weitnauer M, Kietzmann T, Hess J, Görlach A
Antioxid Redox Signal. 2006
PubMed ID: 16987004
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.
Li J, Stouffs M, Serrander L, Banfi B, Bettiol E, Charnay Y, Steger K, Krause KH, Jaconi ME
Mol Biol Cell. 2006
PubMed ID: 16775014
The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice.
Wu DC, Ré DB, Nagai M, Ischiropoulos H, Przedborski S
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16877542
Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN
Immunity. 2006
PubMed ID: 16872848
Synaptic plasticity deficits and mild memory impairments in mouse models of chronic granulomatous disease.
Kishida KT, Hoeffer CA, Hu D, Pao M, Holland SM, Klann E
Mol Cell Biol. 2006
PubMed ID: 16847341
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.
Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC, Lennon-Duménil AM, Seabra MC, Raposo G, Amigorena S
Cell. 2006
PubMed ID: 16839887
Roles of the host oxidative immune response and bacterial antioxidant rubrerythrin during Porphyromonas gingivalis infection.
Mydel P, Takahashi Y, Yumoto H, Sztukowska M, Kubica M, Gibson FC, Kurtz DM, Travis J, Collins LV, Nguyen KA, Genco CA, Potempa J
PLoS Pathog. 2006
PubMed ID: 16895445
The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells.
Okada F, Kobayashi M, Tanaka H, Kobayashi T, Tazawa H, Iuchi Y, Onuma K, Hosokawa M, Dinauer MC, Hunt NH
Am J Pathol. 2006
PubMed ID: 16816381
Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome.
Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND
Metabolism. 2006
PubMed ID: 16784966
Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase.
Johar S, Cave AC, Narayanapanicker A, Grieve DJ, Shah AM
FASEB J. 2006
PubMed ID: 16720735
Role of reactive oxygen species and gp91phox in endothelial dysfunction of pulmonary arteries induced by chronic hypoxia.
Fresquet F, Pourageaud F, Leblais V, Brandes RP, Savineau JP, Marthan R, Muller B
Br J Pharmacol. 2006
PubMed ID: 16715116
Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase.
Murray HW, Xiang Z, Ma X
Am J Trop Med Hyg. 2006
PubMed ID: 16760512
Synergistic effect of mechanical stretch and angiotensin II on superoxide production via NADPH oxidase in vascular smooth muscle cells.
Hitomi H, Fukui T, Moriwaki K, Matsubara K, Sun GP, Rahman M, Nishiyama A, Kiyomoto H, Kimura S, Ohmori K, Abe Y, Kohno M
J Hypertens. 2006
PubMed ID: 16685209
Angiotensin II type 1 receptors and the intestinal microvascular dysfunction induced by ischemia and reperfusion.
Petnehazy T, Cooper D, Stokes KY, Russell J, Wood KC, Granger DN
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16469824
Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide.
Chiang E, Dang O, Anderson K, Matsuzawa A, Ichijo H, David M
J Immunol. 2006
PubMed ID: 16670275
A splice-supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD).
Rump A, Rösen-Wolff A, Gahr M, Seidenberg J, Roos C, Walter L, Günther V, Roesler J
Gene. 2006
PubMed ID: 16516412
Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction.
Weissmann N, Zeller S, Schäfer RU, Turowski C, Ay M, Quanz K, Ghofrani HA, Schermuly RT, Fink L, Seeger W, Grimminger F
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16357364
Glycated proteins stimulate reactive oxygen species production in cardiac myocytes: involvement of Nox2 (gp91phox)-containing NADPH oxidase.
Zhang M, Kho AL, Anilkumar N, Chibber R, Pagano PJ, Shah AM, Cave AC
Circulation. 2006
PubMed ID: 16505175
NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox.
Anrather J, Racchumi G, Iadecola C
J Biol Chem. 2006
PubMed ID: 16407283
Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin.
Block ML, Li G, Qin L, Wu X, Pei Z, Wang T, Wilson B, Yang J, Hong JS
FASEB J. 2006
PubMed ID: 16449797
Neuroprotective effect of hyperbaric oxygen in a rat model of subarachnoid hemorrhage.
Ostrowski RP, Colohan AR, Zhang JH
Acta Neurochir Suppl. 2006
PubMed ID: 16671452
Genetic polymorphisms and susceptibility to lung disease.
Lee PL, West C, Crain K, Wang L
J Negat Results Biomed. 2006
PubMed ID: 16608528
Calcium paradox of aldosteronism and the role of the parathyroid glands.
Vidal A, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC, Weber KT
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16373592
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.
Li Q, Harraz MM, Zhou W, Zhang LN, Ding W, Zhang Y, Eggleston T, Yeaman C, Banfi B, Engelhardt JF
Mol Cell Biol. 2006
PubMed ID: 16354686
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge.
Lomas-Neira J, Chung CS, Perl M, Gregory S, Biffl W, Ayala A
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16157517
Lung endothelial cell proliferation with decreased shear stress is mediated by reactive oxygen species.
Milovanova T, Chatterjee S, Manevich Y, Kotelnikova I, Debolt K, Madesh M, Moore JS, Fisher AB
Am J Physiol Cell Physiol. 2006
PubMed ID: 16107509
Hypoxic pulmonary hypertension: role of superoxide and NADPH oxidase (gp91phox).
Liu JQ, Zelko IN, Erbynn EM, Sham JS, Folz RJ
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16085672
Bile salt-induced apoptosis involves NADPH oxidase isoform activation.
Reinehr R, Becker S, Keitel V, Eberle A, Grether-Beck S, Häussinger D
Gastroenterology. 2005
PubMed ID: 16344068
Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent.
Zhang Q, Matsuzaki I, Chatterjee S, Fisher AB
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 16280460
Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning.
Bell RM, Cave AC, Johar S, Hearse DJ, Shah AM, Shattock MJ
FASEB J. 2005
PubMed ID: 16236999
Colonic blood flow responses in experimental colitis: time course and underlying mechanisms.
Mori M, Stokes KY, Vowinkel T, Watanabe N, Elrod JW, Harris NR, Lefer DJ, Hibi T, Granger DN
Am J Physiol Gastrointest Liver Physiol. 2005
PubMed ID: 16081759
IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2.
Ikeda S, Yamaoka-Tojo M, Hilenski L, Patrushev NA, Anwar GM, Quinn MT, Ushio-Fukai M
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 16179592
Expression and modulation of an NADPH oxidase in mammalian astrocytes.
Abramov AY, Jacobson J, Wientjes F, Hothersall J, Canevari L, Duchen MR
J Neurosci. 2005
PubMed ID: 16207877
Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease.
Goebel WS, Mark LA, Billings SD, Meyers JL, Pech N, Travers JB, Dinauer MC
J Invest Dermatol. 2005
PubMed ID: 16185269
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.
Underhill DM, Rossnagle E, Lowell CA, Simmons RM
Blood. 2005
PubMed ID: 15956283
Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation.
Qin L, Li G, Qian X, Liu Y, Wu X, Liu B, Hong JS, Block ML
Glia. 2005
PubMed ID: 15920727
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase.
Crandall H, Ma Y, Dunn DM, Sundsbak RS, Zachary JF, Olofsson P, Holmdahl R, Weis JH, Weiss RB, Teuscher C, Weis JJ
Am J Pathol. 2005
PubMed ID: 16127156
Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes.
He YY, Huang JL, Block ML, Hong JS, Chignell CF
J Invest Dermatol. 2005
PubMed ID: 16117799
NADPH oxidase restrains the matrix metalloproteinase activity of macrophages.
Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW
J Biol Chem. 2005
PubMed ID: 15983040
Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections.
Potter SM, Mitchell AJ, Cowden WB, Sanni LA, Dinauer M, de Haan JB, Hunt NH
Infect Immun. 2005
PubMed ID: 16041008
gp91phox-containing NAD(P)H oxidase mediates attenuation of nitric oxide-dependent control of myocardial oxygen consumption by ANG II.
Kinugawa S, Zhang J, Messina E, Walsh E, Huang H, Kaminski PM, Wolin MS, Hintze TH
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15778277
Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase.
Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M
Blood. 2005
PubMed ID: 15718414
Characterization of mitochondrial and extra-mitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity.
Piccoli C, Ria R, Scrima R, Cela O, D'Aprile A, Boffoli D, Falzetti F, Tabilio A, Capitanio N
J Biol Chem. 2005
PubMed ID: 15883163
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes.
Li J, Baud O, Vartanian T, Volpe JJ, Rosenberg PA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15998743
Identification of non-mitochondrial NADPH oxidase and the spatio-temporal organization of its components in mouse spermatozoa.
Shukla S, Jha RK, Laloraya M, Kumar PG
Biochem Biophys Res Commun. 2005
PubMed ID: 15850784
Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic mice.
Wood KC, Hebbel RP, Granger DN
FASEB J. 2005
PubMed ID: 15923406
Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia.
Tojo T, Ushio-Fukai M, Yamaoka-Tojo M, Ikeda S, Patrushev N, Alexander RW
Circulation. 2005
PubMed ID: 15867174
NADPH oxidase involvement in the pathology of Helicobacter pylori infection.
Keenan JI, Peterson RA, Hampton MB
Free Radic Biol Med. 2005
PubMed ID: 15808416
Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase.
Becker JS, Adler A, Schneeberger A, Huang H, Wang Z, Walsh E, Koller A, Hintze TH
Circulation. 2005
PubMed ID: 15851618
Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation.
Li XJ, Grunwald D, Mathieu J, Morel F, Stasia MJ
J Biol Chem. 2005
PubMed ID: 15684431
Immunohistochemical study of p47Phox and gp91Phox distributions in rat brain.
Kim MJ, Shin KS, Chung YB, Jung KW, Cha CI, Shin DH
Brain Res. 2005
PubMed ID: 15804439
Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression.
Peng T, Lu X, Feng Q
Circulation. 2005
PubMed ID: 15795323
Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox.
Baniulis D, Burritt JB, Taylor RM, Dinauer MC, Heyworth PG, Parkos CA, Magnusson KE, Jesaitis AJ
Eur J Haematol. 2005
PubMed ID: 15777347
Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.
Touyz RM, Mercure C, He Y, Javeshghani D, Yao G, Callera GE, Yogi A, Lochard N, Reudelhuber TL
Hypertension. 2005
PubMed ID: 15753233
NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II.
Sun C, Sellers KW, Sumners C, Raizada MK
Circ Res. 2005
PubMed ID: 15746442
HOXA9 activates transcription of the gene encoding gp91Phox during myeloid differentiation.
Bei L, Lu Y, Eklund EA
J Biol Chem. 2005
PubMed ID: 15681849
The DNA sequence of the human X chromosome.
Ross MT, Grafham DV, Coffey AJ, Scherer S, McLay K, Muzny D, Platzer M, Howell GR, Burrows C, Bird CP, Frankish A, Lovell FL, Howe KL, Ashurst JL, Fulton RS, Sudbrak R, Wen G, Jones MC, Hurles ME, Andrews TD, Scott CE, Searle S, Ramser J, Whittaker A, Deadman R, Carter NP, Hunt SE, Chen R, Cree A, Gunaratne P, Havlak P, Hodgson A, Metzker ML, Richards S, Scott G, Steffen D, Sodergren E, Wheeler DA, Worley KC, Ainscough R, Ambrose KD, Ansari-Lari MA, Aradhya S, Ashwell RI, Babbage AK, Bagguley CL, Ballabio A, Banerjee R, Barker GE, Barlow KF, Barrett IP, Bates KN, Beare DM, Beasley H, Beasley O, Beck A, Bethel G, Blechschmidt K, Brady N, Bray-Allen S, Bridgeman AM, Brown AJ, Brown MJ, Bonnin D, Bruford EA, Buhay C, Burch P, Burford D, Burgess J, Burrill W, Burton J, Bye JM, Carder C, Carrel L, Chako J, Chapman JC, Chavez D, Chen E, Chen G, Chen Y, Chen Z, Chinault C, Ciccodicola A, Clark SY, Clarke G, Clee CM, Clegg S, Clerc-Blankenburg K, Clifford K, Cobley V, Cole CG, Conquer JS, Corby N, Connor RE, David R, Davies J, Davis C, Davis J, Delgado O, Deshazo D, Dhami P, Ding Y, Dinh H, Dodsworth S, Draper H, Dugan-Rocha S, Dunham A, Dunn M, Durbin KJ, Dutta I, Eades T, Ellwood M, Emery-Cohen A, Errington H, Evans KL, Faulkner L, Francis F, Frankland J, Fraser AE, Galgoczy P, Gilbert J, Gill R, Glöckner G, Gregory SG, Gribble S, Griffiths C, Grocock R, Gu Y, Gwilliam R, Hamilton C, Hart EA, Hawes A, Heath PD, Heitmann K, Hennig S, Hernandez J, Hinzmann B, Ho S, Hoffs M, Howden PJ, Huckle EJ, Hume J, Hunt PJ, Hunt AR, Isherwood J, Jacob L, Johnson D, Jones S, de Jong PJ, Joseph SS, Keenan S, Kelly S, Kershaw JK, Khan Z, Kioschis P, Klages S, Knights AJ, Kosiura A, Kovar-Smith C, Laird GK, Langford C, Lawlor S, Leversha M, Lewis L, Liu W, Lloyd C, Lloyd DM, Loulseged H, Loveland JE, Lovell JD, Lozado R, Lu J, Lyne R, Ma J, Maheshwari M, Matthews LH, McDowall J, McLaren S, McMurray A, Meidl P, Meitinger T, Milne S, Miner G, Mistry SL, Morgan M, Morris S, Müller I, Mullikin JC, Nguyen N, Nordsiek G, Nyakatura G, O'Dell CN, Okwuonu G, Palmer S, Pandian R, Parker D, Parrish J, Pasternak S, Patel D, Pearce AV, Pearson DM, Pelan SE, Perez L, Porter KM, Ramsey Y, Reichwald K, Rhodes S, Ridler KA, Schlessinger D, Schueler MG, Sehra HK, Shaw-Smith C, Shen H, Sheridan EM, Shownkeen R, Skuce CD, Smith ML, Sotheran EC, Steingruber HE, Steward CA, Storey R, Swann RM, Swarbreck D, Tabor PE, Taudien S, Taylor T, Teague B, Thomas K, Thorpe A, Timms K, Tracey A, Trevanion S, Tromans AC, d'Urso M, Verduzco D, Villasana D, Waldron L, Wall M, Wang Q, Warren J, Warry GL, Wei X, West A, Whitehead SL, Whiteley MN, Wilkinson JE, Willey DL, Williams G, Williams L, Williamson A, Williamson H, Wilming L, Woodmansey RL, Wray PW, Yen J, Zhang J, Zhou J, Zoghbi H, Zorilla S, Buck D, Reinhardt R, Poustka A, Rosenthal A, Lehrach H, Meindl A, Minx PJ, Hillier LW, Willard HF, Wilson RK, Waterston RH, Rice CM, Vaudin M, Coulson A, Nelson DL, Weinstock G, Sulston JE, Durbin R, Hubbard T, Gibbs RA, Beck S, Rogers J, Bentley DR
Nature. 2005
PubMed ID: 15772651
Susceptibility of germfree phagocyte oxidase- and nitric oxide synthase 2-deficient mice, defective in the production of reactive metabolites of both oxygen and nitrogen, to mucosal and systemic candidiasis of endogenous origin.
Balish E, Warner TF, Nicholas PJ, Paulling EE, Westwater C, Schofield DA
Infect Immun. 2005
PubMed ID: 15731028
Expression and localization of NOX2 and NOX4 in primary human endothelial cells.
Van Buul JD, Fernandez-Borja M, Anthony EC, Hordijk PL
Antioxid Redox Signal. 2005
PubMed ID: 15706079
Slc11a1-mediated resistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections does not require functional inducible nitric oxide synthase or phagocyte oxidase activity.
White JK, Mastroeni P, Popoff JF, Evans CA, Blackwell JM
J Leukoc Biol. 2005
PubMed ID: 15601666
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide.
Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C
J Neurosci. 2005
PubMed ID: 15716413
Expression of gp91phox/Nox2 in COS-7 cells: cellular localization of the protein and the detection of outward proton currents.
Murillo I, Henderson LM
Biochem J. 2005
PubMed ID: 15377283
Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation.
Fürst R, Brueckl C, Kuebler WM, Zahler S, Krötz F, Görlach A, Vollmar AM, Kiemer AK
Circ Res. 2005
PubMed ID: 15569826
Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction.
Matsuzaki I, Chatterjee S, Debolt K, Manevich Y, Zhang Q, Fisher AB
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15331375
Unusual late presentation of X-linked chronic granulomatous disease in an adult female with a somatic mosaic for a novel mutation in CYBB.
Wolach B, Scharf Y, Gavrieli R, de Boer M, Roos D
Blood. 2005
PubMed ID: 15308575
Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals.
Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner TA, Iadecola C
Circ Res. 2004
PubMed ID: 15499027
Iron and oxidative stress in renal insufficiency.
Lim CS, Vaziri ND
Am J Nephrol. 2004
PubMed ID: 15550752
Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease.
Goebel WS, Pech NK, Dinauer MC
Blood Cells Mol Dis. 2004
PubMed ID: 15528159
Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.
Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, Brandes RP
J Biol Chem. 2004
PubMed ID: 15322091
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Investigation of the contribution of histidine 119 to the conduction of protons through human Nox2.
Mankelow TJ, Hu XW, Adams K, Henderson LM
Eur J Biochem. 2004
PubMed ID: 15479231
X-linked chronic granulomatous disease: first report of mutations in patients of Argentina.
Barese C, Copelli S, Zandomeni R, Oleastro M, Zelazko M, Rivas EM
J Pediatr Hematol Oncol. 2004
PubMed ID: 15454837
Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice.
Swain SD, Wright TW, Degel PM, Gigliotti F, Harmsen AG
Infect Immun. 2004
PubMed ID: 15385471
Functional analysis of two-amino acid substitutions in gp91 phox in a patient with X-linked flavocytochrome b558-positive chronic granulomatous disease by means of transgenic PLB-985 cells.
Bionda C, Li XJ, van Bruggen R, Eppink M, Roos D, Morel F, Stasia MJ
Hum Genet. 2004
PubMed ID: 15338276
Mitochondrial transmembrane potential is diminished in phorbol myristate acetate-stimulated peritoneal resident macrophages isolated from wild-type mice, but not in those from gp91-phox-deficient mice.
Kobayashi T, Ogawa Y, Watanabe Y, Furuya M, Kataoka S, Garcia del Saz E, Tsunawaki S, Dinauer MC, Seguchi H
Histochem Cell Biol. 2004
PubMed ID: 15243751
Attenuated Salmonella typhimurium htrA mutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers.
Mutunga M, Graham S, De Hormaeche RD, Musson JA, Robinson JH, Mastroeni P, Khan CM, Hormaeche CE
Vaccine. 2004
PubMed ID: 15364466
Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defense.
Rothfork JM, Timmins GS, Harris MN, Chen X, Lusis AJ, Otto M, Cheung AL, Gresham HD
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15353593
Gene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy.
Liu J, Ormsby A, Oja-Tebbe N, Pagano PJ
Circ Res. 2004
PubMed ID: 15308582
Localization of Nox2 N-terminus using polyclonal antipeptide antibodies.
Paclet MH, Henderson LM, Campion Y, Morel F, Dagher MC
Biochem J. 2004
PubMed ID: 15233623
gp91phox-dependent expression of platelet CD40 ligand.
Pignatelli P, Sanguigni V, Lenti L, Ferro D, Finocchi A, Rossi P, Violi F
Circulation. 2004
PubMed ID: 15249506
Neutrophil NADPH oxidase is reduced at the Anaplasma phagocytophilum phagosome.
IJdo JW, Mueller AC
Infect Immun. 2004
PubMed ID: 15322037
Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins.
Guzik TJ, Sadowski J, Kapelak B, Jopek A, Rudzinski P, Pillai R, Korbut R, Channon KM
Arterioscler Thromb Vasc Biol. 2004
PubMed ID: 15256399
Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury.
Chen Z, Keaney JF, Schulz E, Levison B, Shan L, Sakuma M, Zhang X, Shi C, Hazen SL, Simon DI
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15316118
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation.
Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS
Nat Immunol. 2004
PubMed ID: 15258578
Frontline: control of Anaplasma phagocytophilum, an obligate intracellular pathogen, in the absence of inducible nitric oxide synthase, phagocyte NADPH oxidase, tumor necrosis factor, Toll-like receptor (TLR)2 and TLR4, or the TLR adaptor molecule MyD88.
von Loewenich FD, Scorpio DG, Reischl U, Dumler JS, Bogdan C
Eur J Immunol. 2004
PubMed ID: 15214027
DNA phasing by TA dinucleotide microsatellite length determines in vitro and in vivo expression of the gp91phox subunit of NADPH oxidase and mediates protection against severe malaria.
Uhlemann AC, Szlezák NA, Vonthein R, Tomiuk J, Emmer SA, Lell B, Kremsner PG, Kun JF
J Infect Dis. 2004
PubMed ID: 15181570
Reoxygenation-induced constriction in murine coronary arteries: the role of endothelial NADPH oxidase (gp91phox) and intracellular superoxide.
Liu JQ, Zelko IN, Folz RJ
J Biol Chem. 2004
PubMed ID: 15070892
Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury.
Kusaka I, Kusaka G, Zhou C, Ishikawa M, Nanda A, Granger DN, Zhang JH, Tang J
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 15148062
Cryptic O2- -generating NADPH oxidase in dendritic cells.
Elsen S, Doussière J, Villiers CL, Faure M, Berthier R, Papaioannou A, Grandvaux N, Marche PN, Vignais PV
J Cell Sci. 2004
PubMed ID: 15126623
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.
Jung O, Schreiber JG, Geiger H, Pedrazzini T, Busse R, Brandes RP
Circulation. 2004
PubMed ID: 15037533
A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes.
Chamulitrat W, Stremmel W, Kawahara T, Rokutan K, Fujii H, Wingler K, Schmidt HH, Schmidt R
J Invest Dermatol. 2004
PubMed ID: 15102091
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox.
Maytin M, Siwik DA, Ito M, Xiao L, Sawyer DB, Liao R, Colucci WS
Circulation. 2004
PubMed ID: 14981002
Cerebral microvascular responses to hypercholesterolemia: roles of NADPH oxidase and P-selectin.
Ishikawa M, Stokes KY, Zhang JH, Nanda A, Granger DN
Circ Res. 2004
PubMed ID: 14670846
Mechanisms of immunity to Ehrlichia muris: a model of monocytotropic ehrlichiosis.
Feng HM, Walker DH
Infect Immun. 2004
PubMed ID: 14742542
Assessment of renal functional phenotype in mice lacking gp91PHOX subunit of NAD(P)H oxidase.
Haque MZ, Majid DS
Hypertension. 2004
PubMed ID: 14718366
NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia.
Qin L, Liu Y, Wang T, Wei SJ, Block ML, Wilson B, Liu B, Hong JS
J Biol Chem. 2004
PubMed ID: 14578353
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Null mutation of gp91phox reduces muscle membrane lysis during muscle inflammation in mice.
Nguyen HX, Tidball JG
J Physiol. 2003
PubMed ID: 14555723
Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells.
Chamseddine AH, Miller FJ
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12855428
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell. 2003
PubMed ID: 14651853
Modulation of T-cell costimulation as immunotherapy or immunochemotherapy in experimental visceral leishmaniasis.
Murray HW, Lu CM, Brooks EB, Fichtl RE, DeVecchio JL, Heinzel FP
Infect Immun. 2003
PubMed ID: 14573667
Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy.
Byrne JA, Grieve DJ, Bendall JK, Li JM, Gove C, Lambeth JD, Cave AC, Shah AM
Circ Res. 2003
PubMed ID: 14551238
Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models.
van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts E, Joosten LA, van Lent PL, Coenen-de Roo CJ, Cuzzocrea S, Segal BH, Holland SM, van den Berg WB
Am J Pathol. 2003
PubMed ID: 14507659
NAD(P)H oxidase-generated superoxide anion accounts for reduced control of myocardial O2 consumption by NO in old Fischer 344 rats.
Adler A, Messina E, Sherman B, Wang Z, Huang H, Linke A, Hintze TH
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12915388
Production of N(epsilon)-(carboxymethyl)lysine is impaired in mice deficient in NADPH oxidase: a role for phagocyte-derived oxidants in the formation of advanced glycation end products during inflammation.
Anderson MM, Heinecke JW
Diabetes. 2003
PubMed ID: 12882933
Induction of antimicrobial pathways during early-phase immune response to Salmonella spp. in murine macrophages: gamma interferon (IFN-gamma) and upregulation of IFN-gamma receptor alpha expression are required for NADPH phagocytic oxidase gp91-stimulated
Foster N, Hulme SD, Barrow PA
Infect Immun. 2003
PubMed ID: 12874355
Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.
Gao HM, Liu B, Hong JS
J Neurosci. 2003
PubMed ID: 12867501
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases.
Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, Sumimoto H
J Biol Chem. 2003
PubMed ID: 12716910
Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice.
TeKippe M, Harrison DE, Chen J
Exp Hematol. 2003
PubMed ID: 12829028
Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity.
Blanchard TG, Yu F, Hsieh CL, Redline RW
J Infect Dis. 2003
PubMed ID: 12721941
Proton conduction through full-length gp91phox requires histidine 115.
Mankelow TJ, Henderson LM
Protoplasma. 2003
PubMed ID: 12768347
NAD(P)H oxidase mediates angiotensin II-induced vascular macrophage infiltration and medial hypertrophy.
Liu J, Yang F, Yang XP, Jankowski M, Pagano PJ
Arterioscler Thromb Vasc Biol. 2003
PubMed ID: 12637340
Inhibition of the neutrophil NADPH oxidase by adenosine is associated with increased movement of flavocytochrome b between subcellular fractions.
Swain SD, Siemsen DW, Nelson LK, Sipes KM, Hanson AJ, Quinn MT
Inflammation. 2003
PubMed ID: 12772776
Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay.
Jirapongsananuruk O, Malech HL, Kuhns DB, Niemela JE, Brown MR, Anderson-Cohen M, Fleisher TA
J Allergy Clin Immunol. 2003
PubMed ID: 12589359
SATB1 makes a complex with p300 and represses gp91(phox) promoter activity.
Fujii Y, Kumatori A, Nakamura M
Microbiol Immunol. 2003
PubMed ID: 14605447
Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension.
Vaziri ND, Lin CY, Farmand F, Sindhu RK
Kidney Int. 2003
PubMed ID: 12472782
Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency.
Vaziri ND, Dicus M, Ho ND, Boroujerdi-Rad L, Sindhu RK
Kidney Int. 2003
PubMed ID: 12472781
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Requisite elements in vaccine immunity to Blastomyces dermatitidis: plasticity uncovers vaccine potential in immune-deficient hosts.
Wüthrich M, Filutowicz HI, Warner T, Klein BS
J Immunol. 2002
PubMed ID: 12471131
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Cytochrome b558-dependent NAD(P)H oxidase-phox units in smooth muscle and macrophages of atherosclerotic lesions.
Kalinina N, Agrotis A, Tararak E, Antropova Y, Kanellakis P, Ilyinskaya O, Quinn MT, Smirnov V, Bobik A
Arterioscler Thromb Vasc Biol. 2002
PubMed ID: 12482831
Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: role of gp91(phox).
Rey FE, Li XC, Carretero OA, Garvin JL, Pagano PJ
Circulation. 2002
PubMed ID: 12417549
Virulent but not avirulent Mycobacterium tuberculosis can evade the growth inhibitory action of a T helper 1-dependent, nitric oxide Synthase 2-independent defense in mice.
Jung YJ, LaCourse R, Ryan L, North RJ
J Exp Med. 2002
PubMed ID: 12370260
Glutamine plays a role in superoxide production and the expression of p47phox, p22phox and gp91phox in rat neutrophils.
Pithon-Curi TC, Levada AC, Lopes LR, Doi SQ, Curi R
Clin Sci (Lond). 2002
PubMed ID: 12241540
Pathology of a mouse model of x-linked chronic granulomatous disease.
Bingel SA
Contemp Top Lab Anim Sci. 2002
PubMed ID: 12213046
Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function.
Biberstine-Kinkade KJ, Yu L, Stull N, LeRoy B, Bennett S, Cross A, Dinauer MC
J Biol Chem. 2002
PubMed ID: 12042318
CYBB mutation analysis in X-linked chronic granulomatous disease.
Jirapongsananuruk O, Niemela JE, Malech HL, Fleisher TA
Clin Immunol. 2002
PubMed ID: 12139950
Developmental regulation of O(2) sensing in neonatal adrenal chromaffin cells from wild-type and NADPH-oxidase-deficient mice.
Thompson RJ, Farragher SM, Cutz E, Nurse CA
Pflugers Arch. 2002
PubMed ID: 12136274
Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans.
Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H
J Infect Dis. 2002
PubMed ID: 12085336
Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells.
Li JM, Shah AM
J Biol Chem. 2002
PubMed ID: 11893732
Molecular and functional characterization of a new X-linked chronic granulomatous disease variant (X91+) case with a double missense mutation in the cytosolic gp91phox C-terminal tail.
Stasia MJ, Lardy B, Maturana A, Rousseau P, Martel C, Bordigoni P, Demaurex N, Morel F
Biochim Biophys Acta. 2002
PubMed ID: 11997083
Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice.
Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, Malik AB
J Immunol. 2002
PubMed ID: 11937554
Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558 II.
Dang PM, Cross AR, Quinn MT, Babior BM
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11917128
PU.1 is dominant and HAF-1 supplementary for activation of the gp91(phox) promoter in human monocytic PLB-985 cells.
Islam MR, Fan C, Fujii Y, Hao LJ, Suzuki S, Kumatori A, Yang D, Rusvai E, Suzuki N, Kikuchi H, Nakamura M
J Biochem. 2002
PubMed ID: 11926990
Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease.
Petersen JE, Hiran TS, Goebel WS, Johnson C, Murphy RC, Azmi FH, Hood AF, Travers JB, Dinauer MC
J Invest Dermatol. 2002
PubMed ID: 11874480
Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis.
Ko J, Gendron-Fitzpatrick A, Splitter GA
J Immunol. 2002
PubMed ID: 11859135
Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells.
Fan J, Frey RS, Rahman A, Malik AB
J Biol Chem. 2002
PubMed ID: 11729200
Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice.
Bendall JK, Cave AC, Heymes C, Gall N, Shah AM
Circulation. 2002
PubMed ID: 11804982
Characteristics of carotid body chemosensitivity in NADPH oxidase-deficient mice.
He L, Chen J, Dinger B, Sanders K, Sundar K, Hoidal J, Fidone S
Am J Physiol Cell Physiol. 2002
PubMed ID: 11742795
p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice.
Barry-Lane PA, Patterson C, van der Merwe M, Hu Z, Holland SM, Yeh ET, Runge MS
J Clin Invest. 2001
PubMed ID: 11714743
Effects of oxidant stress on inflammation and survival of iNOS knockout mice after marrow transplantation.
Yang S, Porter VA, Cornfield DN, Milla C, Panoskaltsis-Mortari A, Blazar BR, Haddad IY
Am J Physiol Lung Cell Mol Physiol. 2001
PubMed ID: 11557596
A second case of somatic triple mosaicism in the CYBB gene causing chronic granulomatous disease.
Noack D, Heyworth PG, Kyono W, Cross AR
Hum Genet. 2001
PubMed ID: 11511930
Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis.
Wipke BT, Allen PM
J Immunol. 2001
PubMed ID: 11466382
Characterization of 11 novel mutations in the X-linked chronic granulomatous disease (CYBB gene).
Gérard B, El Benna J, Alcain F, Gougerot-Pocidalo MA, Grandchamp B, Chollet-Martin S
Hum Mutat. 2001
PubMed ID: 11462241
Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease.
Dinauer MC, Gifford MA, Pech N, Li LL, Emshwiller P
Blood. 2001
PubMed ID: 11389011
Respiratory control in neonatal mice with NADPH oxidase deficiency.
Kazemian P, Stephenson R, Yeger H, Cutz E
Respir Physiol. 2001
PubMed ID: 11348637
Role of NADPH oxidase in the vascular hypertrophic and oxidative stress response to angiotensin II in mice.
Wang HD, Xu S, Johns DG, Du Y, Quinn MT, Cayatte AJ, Cohen RA
Circ Res. 2001
PubMed ID: 11349005
Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways.
Lassègue B, Sorescu D, Szöcs K, Yin Q, Akers M, Zhang Y, Grant SL, Lambeth JD, Griendling KK
Circ Res. 2001
PubMed ID: 11348997
Small angle neutron scattering and gel filtration analyses of neutrophil NADPH oxidase cytosolic factors highlight the role of the C-terminal end of p47phox in the association with p40phox.
Grizot S, Grandvaux N, Fieschi F, Fauré J, Massenet C, Andrieu JP, Fuchs A, Vignais PV, Timmins PA, Dagher MC, Pebay-Peyroula E
Biochemistry. 2001
PubMed ID: 11258927
Assembly of the neutrophil respiratory burst oxidase: a direct interaction between p67PHOX and cytochrome b558.
Dang PM, Cross AR, Babior BM
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248021
Expression of p22-phox and gp91-phox, essential components of NADPH oxidase, increases after myocardial infarction.
Fukui T, Yoshiyama M, Hanatani A, Omura T, Yoshikawa J, Abe Y
Biochem Biophys Res Commun. 2001
PubMed ID: 11243862
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Mechanisms underlying endothelial dysfunction in diabetes mellitus.
Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T
Circ Res. 2001
PubMed ID: 11157681
Vascular NAD(P)H oxidase is distinct from the phagocytic enzyme and modulates vascular reactivity control.
Souza HP, Laurindo FR, Ziegelstein RC, Berlowitz CO, Zweier JL
Am J Physiol Heart Circ Physiol. 2001
PubMed ID: 11158964
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Novel homologs of gp91phox.
Lambeth JD, Cheng G, Arnold RS, Edens WA
Trends Biochem Sci. 2000
PubMed ID: 11050424
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice.
Beck PL, Xavier R, Lu N, Nanda NN, Dinauer M, Podolsky DK, Seed B
Gastroenterology. 2000
PubMed ID: 10982764
NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells.
Kikuchi H, Hikage M, Miyashita H, Fukumoto M
Gene. 2000
PubMed ID: 10974555
Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells.
Bayraktutan U, Blayney L, Shah AM
Arterioscler Thromb Vasc Biol. 2000
PubMed ID: 10938010
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca(2+)](i) and respiratory responses to hypoxia.
Roy A, Rozanov C, Mokashi A, Daudu P, Al-mehdi AB, Shams H, Lahiri S
Brain Res. 2000
PubMed ID: 10924691
Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo.
Mastroeni P, Vazquez-Torres A, Fang FC, Xu Y, Khan S, Hormaeche CE, Dougan G
J Exp Med. 2000
PubMed ID: 10899910
Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro.
Vazquez-Torres A, Jones-Carson J, Mastroeni P, Ischiropoulos H, Fang FC
J Exp Med. 2000
PubMed ID: 10899909
Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.
Banerjee R, Anguita J, Fikrig E
Infect Immun. 2000
PubMed ID: 10858261
Statistical and mutational analysis of chronic granulomatous disease in Japan with special reference to gp91-phox and p22-phox deficiency.
Ishibashi F, Nunoi H, Endo F, Matsuda I, Kanegasaki S
Hum Genet. 2000
PubMed ID: 10914676
NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice.
Fu XW, Wang D, Nurse CA, Dinauer MC, Cutz E
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10760304
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Evidence that the product of the human X-linked CGD gene, gp91-phox, is a voltage-gated H(+) pathway.
Henderson LM, Meech RW
J Gen Physiol. 1999
PubMed ID: 10578014
Developmental expression of NADPH phagocytic oxidase components in mouse embryos.
Baehner RL, Millar-Groff S, Bringas P
Pediatr Res. 1999
PubMed ID: 10447107
O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase.
Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R, Nelson DP, Dinauer MC, Weir EK
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10393927
Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both.
Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF
Shock. 1999
PubMed ID: 10220301
Uncommon missense and splice mutations and resulting biochemical phenotypes in German patients with X-linked chronic granulomatous disease.
Roesler J, Heyden S, Burdelski M, Schäfer H, Kreth HW, Lehmann R, Paul D, Marzahn J, Gahr M, Rösen-Wolff A
Exp Hematol. 1999
PubMed ID: 10089913
Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani.
Murray HW, Nathan CF
J Exp Med. 1999
PubMed ID: 9989990
Molecular analysis of chronic granulomatous disease caused by defects in gp91-phox.
Patiño PJ, Perez JE, Lopez JA, Condino-Neto A, Grumach AS, Botero JH, Curnutte JT, García de Olarte D
Hum Mutat. 1999
PubMed ID: 9888386
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase.
Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C
Immunity. 1999
PubMed ID: 10023768
The central role of CD4(+) T cells in the antitumor immune response.
Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D, Levitsky H
J Exp Med. 1998
PubMed ID: 9858522
Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients.
Dusi S, Nadalini KA, Donini M, Zentilin L, Wientjes FB, Roos D, Giacca M, Rossi F
J Immunol. 1998
PubMed ID: 9794433
Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.
Yoshida LS, Saruta F, Yoshikawa K, Tatsuzawa O, Tsunawaki S
J Biol Chem. 1998
PubMed ID: 9774399
Nonhomologous recombination between the cytochrome b558 heavy chain gene (CYBB) and LINE-1 causes an X-linked chronic granulomatous disease.
Kumatori A, Faizunnessa NN, Suzuki S, Moriuchi T, Kurozumi H, Nakamura M
Genomics. 1998
PubMed ID: 9790760
A novel mutation at a probable heme-binding ligand in neutrophil cytochrome b558 in atypical X-linked chronic granulomatous disease.
Tsuda M, Kaneda M, Sakiyama T, Inana I, Owada M, Kiryu C, Shiraishi T, Kakinuma K
Hum Genet. 1998
PubMed ID: 9856476
Genetic analysis of 13 families with X-linked chronic granulomatous disease reveals a low proportion of sporadic patients and a high proportion of sporadic carriers.
Ariga T, Furuta H, Cho K, Sakiyama Y
Pediatr Res. 1998
PubMed ID: 9667376
Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.
Iwama A, Zhang P, Darlington GJ, McKercher SR, Maki R, Tenen DG
Nucleic Acids Res. 1998
PubMed ID: 9611252
X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase.
Rae J, Newburger PE, Dinauer MC, Noack D, Hopkins PJ, Kuruto R, Curnutte JT
Am J Hum Genet. 1998
PubMed ID: 9585602
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase.
Walder CE, Green SP, Darbonne WC, Mathias J, Rae J, Dinauer MC, Curnutte JT, Thomas GR
Stroke. 1997
PubMed ID: 9368573
Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes.
Dinauer MC, Deck MB, Unanue ER
J Immunol. 1997
PubMed ID: 9190903
Identification and characterization of TF1(phox), a DNA-binding protein that increases expression of gp91(phox) in PLB985 myeloid leukemia cells.
Eklund EA, Kakar R
J Biol Chem. 1997
PubMed ID: 9083071
p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain.
Sathyamoorthy M, de Mendez I, Adams AG, Leto TL
J Biol Chem. 1997
PubMed ID: 9083043
An in-frame triplet deletion within the gp91-phox gene in an adult X-linked chronic granulomatous disease patient with residual NADPH-oxidase activity.
Jendrossek V, Ritzel A, Neubauer B, Heyden S, Gahr M
Eur J Haematol. 1997
PubMed ID: 9111587
Retroviral-mediated gene transfer of gp91phox into bone marrow cells rescues defect in host defense against Aspergillus fumigatus in murine X-linked chronic granulomatous disease.
Björgvinsdóttir H, Ding C, Pech N, Gifford MA, Li LL, Dinauer MC
Blood. 1997
PubMed ID: 8978275
Identification of mutations in seven Chinese patients with X-linked chronic granulomatous disease.
Hui YF, Chan SY, Lau YL
Blood. 1996
PubMed ID: 8916969
The mouse X-linked developmental mutant, tattered, lies between DXMit55 and Xkh and is associated with hyperkeratinization.
Uwechue IC, Cooper BF, Goble C, Hacker T, Blair HJ, Burke DT, Herman G, Boyd Y
Genomics. 1996
PubMed ID: 8921395
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Cloning of murine gp91phox cDNA and functional expression in a human X-linked chronic granulomatous disease cell line.
Björgvinsdóttir H, Zhen L, Dinauer MC
Blood. 1996
PubMed ID: 8634451
Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp).
Battinelli EM, Boyd Y, Craig IW, Breakefield XO, Chen ZY
Mamm Genome. 1996
PubMed ID: 8835523
A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa.
Meindl A, Carvalho MR, Herrmann K, Lorenz B, Achatz H, Lorenz B, Apfelstedt-Sylla E, Wittwer B, Ross M, Meitinger T
Hum Mol Genet. 1995
PubMed ID: 8634708
High-resolution comparative mapping of the proximal region of the mouse X chromosome.
Blair HJ, Ho M, Monaco AP, Fisher S, Craig IW, Boyd Y
Genomics. 1995
PubMed ID: 8530041
Essential functions of synapsins I and II in synaptic vesicle regulation.
Rosahl TW, Spillane D, Missler M, Herz J, Selig DK, Wolff JR, Hammer RE, Malenka RC, Südhof TC
Nature. 1995
PubMed ID: 7777057
Genetic analyses of tattered, an X-linked dominant, developmental mouse mutation.
Merrell K, Gonzales JC, Wells S, Calame K, Herman GE
Mamm Genome. 1995
PubMed ID: 7613037
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production.
Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, Orkin SH, Doerschuk CM, Dinauer MC
Nat Genet. 1995
PubMed ID: 7719350
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets.
Leto TL, Adams AG, de Mendez I
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7938008
Two novel point mutations in the cytochrome b 558 heavy chain gene, detected in two Japanese patients with X-linked chronic granulomatous disease.
Ariga T, Sakiyama Y, Matsumoto S
Hum Genet. 1994
PubMed ID: 7927345
Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558.
Newburger PE, Skalnik DG, Hopkins PJ, Eklund EA, Curnutte JT
J Clin Invest. 1994
PubMed ID: 8083361
A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.
Leusen JH, de Boer M, Bolscher BG, Hilarius PM, Weening RS, Ochs HD, Roos D, Verhoeven AJ
J Clin Invest. 1994
PubMed ID: 8182143
A 40-base-pair duplication in the gp91-phox gene leading to X-linked chronic granulomatous disease.
Rabbani H, de Boer M, Ahlin A, Sundin U, Elinder G, Hammarström L, Palmblad J, Smith CI, Roos D
Eur J Haematol. 1993
PubMed ID: 7694872
A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease.
Ariga T, Sakiyama Y, Tomizawa K, Imajoh-Ohmi S, Kanegasaki S, Matsumoto S
Eur J Pediatr. 1993
PubMed ID: 8101486
Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.
Geng Y, Derry JM, Hendrickx J, Coucke P, Willems PR, Barnard PJ
Genomics. 1993
PubMed ID: 8432533
Partial inversion of gene order within a homologous segment on the X chromosome.
Laval SH, Boyd Y
Mamm Genome. 1993
PubMed ID: 8431636
Physical linkage of the A-raf-1, properdin, synapsin I, and TIMP genes on the human and mouse X chromosomes.
Derry JM, Barnard PJ
Genomics. 1992
PubMed ID: 1572636
Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.
Derry JM, Barnard PJ
Genomics. 1991
PubMed ID: 1679744
Point mutations in the beta-subunit of cytochrome b558 leading to X-linked chronic granulomatous disease.
Bolscher BG, de Boer M, de Klein A, Weening RS, Roos D
Blood. 1991
PubMed ID: 1710153
Detailed genetic mapping of the A-raf proto-oncogene on the mouse X chromosome.
Grant SG, Chapman VM
Oncogene. 1991
PubMed ID: 2011396
Linkage of the erythroid transcription factor gene (Gf-1) to the proximal region of the X chromosome of mice.
Chapman VM, Stephenson DA, Mullins LJ, Keitz BT, Disteche C, Orkin SH
Genomics. 1991
PubMed ID: 2004781
The HIV core protein p24 inhibits interferon-gamma-induced increase of HLA-DR and cytochrome b heavy chain mRNA levels in the human monocyte-like cell line THP1.
Nong Y, Kandil O, Tobin EH, Rose RM, Remold HG
Cell Immunol. 1991
PubMed ID: 1905983
Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
Dinauer MC, Pierce EA, Bruns GA, Curnutte JT, Orkin SH
J Clin Invest. 1990
PubMed ID: 2243141
Efficient linkage of 10 loci in the proximal region of the mouse X chromosome.
Mullins LJ, Stephenson DA, Grant SG, Chapman VM
Genomics. 1990
PubMed ID: 2110546
Unusual molecular characteristics of a repeat sequence island within a Giemsa-positive band on the mouse X chromosome.
Nasir J, Fisher EM, Brockdorff N, Disteche CM, Lyon MF, Brown SD
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2296595
Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.
Barnard PJ, Derry JM, Ryder-Cook AS, Zander NF, Kilimann MW
Cytogenet Cell Genet. 1990
PubMed ID: 1973380
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease.
Dinauer MC, Curnutte JT, Rosen H, Orkin SH
J Clin Invest. 1989
PubMed ID: 2556453
Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.
Buckle VJ, Fujita N, Ryder-Cook AS, Derry JM, Barnard PJ, Lebo RV, Schofield PR, Seeburg PH, Bateson AN, Darlison MG
Neuron. 1989
PubMed ID: 2561974
Localization of monoamine oxidase A and B genes on the mouse X chromosome.
Derry JM, Lan NC, Shih JC, Barnard EA, Barnard PJ
Nucleic Acids Res. 1989
PubMed ID: 2573045
Localization of the mdx mutation within the mouse dystrophin gene.
Ryder-Cook AS, Sicinski P, Thomas K, Davies KE, Worton RG, Barnard EA, Darlison MG, Barnard PJ
EMBO J. 1988
PubMed ID: 2903046
Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution.
Brockdorff N, Fisher EM, Orkin SH, Lyon MF, Brown SD
Cytogenet Cell Genet. 1988
PubMed ID: 3197451
Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000.
Parkos CA, Allen RA, Cochrane CG, Jesaitis AJ
J Clin Invest. 1987
PubMed ID: 3305576
The X-linked chronic granulomatous disease gene codes for the beta-chain of cytochrome b-245.
Teahan C, Rowe P, Parker P, Totty N, Segal AW
Nature. 1987
PubMed ID: 3600769
The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex.
Dinauer MC, Orkin SH, Brown R, Jesaitis AJ, Parkos CA
Nature. 1987
PubMed ID: 3600768
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location.
Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH
Nature. 1986
PubMed ID: 2425263

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1536	13058	66021
EnsEMBL Gene(s)	ENSG00000165168 LRG_53	ENSMUSG00000015340	ENSRNOG00000003622
Unigene	Hs.292356	Mm.200362	Rn.98491
Homologene	CYBB	Cybb	Cybb
OMIM	300481	N/A	N/A
GeneCards	CYBB	N/A	N/A
Beta Cell Genomics	DT.452942 DT.92448213	DT.101165428 DT.534026 DT.94268983	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1536	13058	66021

External resources from NIDDK Consortium Interconnectivity Network Top Help

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CYBB	CYBA	HPRD	empirical	7938008 11893732
CYBB	NCF2	HPRD	empirical	11917128 11893732 11248021
CYBB	NCF4	HPRD	empirical	11893732
CYBB	RAC1	HPRD	empirical	11893732
CYBB	NCF1	HPRD	empirical	11893732
CYBB	ACTG1	HPRD	empirical	16179592
CYBB	IQGAP1	HPRD	empirical	16179592