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CTLA4

Gene Description:   cytotoxic T-lymphocyte-associated protein 4 Synonyms:   ICOS, CELIAC3, CTLA4, Ctla-4, sCTLA4, Cd152, IDDM12, GRD4, CTLA-4, GSE, Ly-56, CD, CD152, Ctla4 Orthologs:   Human CTLA4 (protein-coding), Mouse Ctla4 (protein-coding), Rat Ctla4 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD Human-Rat: HomoloGene, MGD, RGD Mouse-Rat: HomoloGene, MGD, RGD Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
2q33.2	Human	chr2:204672809..204820058	0.15	12	rs3087243

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd5.1	Mouse	chr1:60883084..62840206	1.96	8	3 no lod score

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 2q33.2 Orthologous Region	Mouse	chr1:60913616..61051726	0.14	3
Human 2q33.2 Orthologous Region	Rat	chr9:59449044..59556611	0.11	1

(Human) GRCh37 - chr2:204732504..204743422 (10.92 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr1:60943844..60972676 (28.83 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr9:59495773..59501300 (5.53 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas       no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for CTLA4: The CTLA4 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs CTLA4   AP2M1   HPRD, MIPS, BioGRID  empirical  9200449  9256472  11583591  CTLA4   CTLA4   HPRD  empirical  11279501  CTLA4   FYN   HPRD  empirical  9712716  9973379  CTLA4   JAK2   HPRD  empirical  10842319  CTLA4   LCK   HPRD  empirical  9712716  9973379  CTLA4   LYN   HPRD  empirical  9712716  CTLA4   PIK3R1   HPRD  empirical  7807015  CTLA4   PPP2R5A   HPRD  empirical  11994459  CTLA4   PTPN11   HPRD  empirical  8638161  CTLA4   STAT5A   HPRD  empirical  16476059  CTLA4   STAT5B   HPRD  empirical  16476059  CTLA4   TXK   HPRD  empirical  9813138  CTLA4   AP1M1   HPRD  empirical  9812899  11583591  CTLA4   CD80   HPRD, IntAct  empirical  7545666  11279502  CTLA4   CD86   HPRD, IntAct  empirical  11279501  11021528  12606712  12071705  12582153  7513726  7694153  11162656

View all

KEGG Network: 4   Autoimmune thyroid disease Human - 5320 Mouse - 5320 Rat - 5320 Cell adhesion molecules (CAMs) Human - 4514 Mouse - 4514 Rat - 4514 Rheumatoid arthritis Human - 5323 Mouse - 5323 Rat - 5323 T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660

Biocarta: 1   The Co-Stimulatory Signal During T-cell Activation Human Mouse

Reactome: 2   Costimulation by the CD28 family REACT_19344 CTLA4 inhibitory signaling REACT_19405

NCI-Nature Pathway Interaction Database: 1   Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene Ontology: 14   Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Response to DNA damage stimulus GO:0006974 External side of plasma membrane GO:0009897 Membrane GO:0016020 Negative regulation of B cell proliferation GO:0030889 T cell costimulation GO:0031295 Positive regulation of apoptosis GO:0043065 Clathrin-coated endocytic vesicle GO:0045334 Negative regulation of regulatory T cell differentiation GO:0045590 Perinuclear region of cytoplasm GO:0048471 B cell receptor signaling pathway GO:0050853

	KEGG Network: 4 Autoimmune thyroid disease Human - 5320 Mouse - 5320 Rat - 5320 Cell adhesion molecules (CAMs) Human - 4514 Mouse - 4514 Rat - 4514 Rheumatoid arthritis Human - 5323 Mouse - 5323 Rat - 5323 T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660
	Biocarta: 1 The Co-Stimulatory Signal During T-cell Activation Human Mouse
	Reactome: 2 Costimulation by the CD28 family REACT_19344 CTLA4 inhibitory signaling REACT_19405
	NCI-Nature Pathway Interaction Database: 1 Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Gene Ontology: 14 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Response to DNA damage stimulus GO:0006974 External side of plasma membrane GO:0009897 Membrane GO:0016020 Negative regulation of B cell proliferation GO:0030889 T cell costimulation GO:0031295 Positive regulation of apoptosis GO:0043065 Clathrin-coated endocytic vesicle GO:0045334 Negative regulation of regulatory T cell differentiation GO:0045590 Perinuclear region of cytoplasm GO:0048471 B cell receptor signaling pathway GO:0050853

Type 1 Diabetes Publications: 136

• A cluster of coregulated genes determines TGF-{beta}-induced regulatory T-cell (Treg) dysfunction in NOD mice.
  D'Alise AM, Ergun A, Hill JA, Mathis D, Benoist C
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21543717
   
  
• The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function.
  Gerold KD, Zheng P, Rainbow DB, Zernecke A, Wicker LS, Kissler S
  Diabetes. 2011
  PubMed ID: 21602513
   
  
• Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes.
  Ei Wafai RJ, Chmaisse HN, Makki RF, Fakhoury H
  Saudi J Kidney Dis Transpl. 2011
  PubMed ID: 21422625
   
  
• A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
  Genes Immun. 2010
  PubMed ID: 20962850
   
  
• Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
  Moriguchi M, Noso S, Kawabata Y, Yamauchi T, Harada T, Komaki K, Babaya N, Hiromine Y, Ito H, Yamagata S, Murata K, Higashimoto T, Park C, Yamamoto A, Ohno Y, Ikegami H
  Metabolism. 2010
  PubMed ID: 20825955
   
  
• Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.
  Andersen MK, Lundgren V, Turunen JA, Forsblom C, Isomaa B, Groop PH, Groop L, Tuomi T
  Diabetes Care. 2010
  PubMed ID: 20805278
   
  
• CTLA-4 -318C/T, +49A/G, and CT60A/G Polymorphisms and Susceptibility to Autoimmune Type 1 Diabetes in Tunisians.
  Benmansour J, Stayoussef M, Al-Jenaidi FA, Rajab MH, Rayana CB, Said HB, Mahjoub T, Almawi WY
  Clin Vaccine Immunol. 2010
  PubMed ID: 20610662
   
  
• Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes.
  Karumuthil-Melethil S, Perez N, Li R, Prabhakar BS, Holterman MJ, Vasu C
  J Immunol. 2010
  PubMed ID: 20483724
   
  
• In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
  Qu HQ, Bradfield JP, Li Q, Kim C, Frackelton E, Grant SF, Hakonarson H, Polychronakos C
  Hum Mol Genet. 2010
  PubMed ID: 20378605
   
  
• Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles.
  Witas HW, Jędrychowska-Dańska K, Zawicki P
  Int J Immunogenet. 2010
  PubMed ID: 20345871
   
  
• Remapping the type I diabetes association of the CTLA4 locus.
  Qu HQ, Bradfield JP, Grant SF, Hakonarson H, Polychronakos C, Type I Diabetes Genetics Consortium
  Genes Immun. 2009
  PubMed ID: 19956097
   
  
• Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in Korean children and adolescents.
  Jung MH, Yu J, Shin CH, Suh BK, Yang SW, Lee BC
  J Korean Med Sci. 2009
  PubMed ID: 19949652
   
  
• An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms.
  Stene LC, Rønningen KS, Bjørnvold M, Undlien DE, Joner G
  Pediatr Diabetes. 2009
  PubMed ID: 19895409
   
  
• CTLA-4 promoter polymorphisms are associated with latent autoimmune diabetes in adults.
  Douroudis K, Prans E, Uibo R
  Hum Immunol. 2009
  PubMed ID: 19735686
   
  
• Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians.
  Korolija M, Renar IP, Hadžija M, Medvidović EP, Pavković P, Jokić M, Hadžija MP
  Diabetes Res Clin Pract. 2009
  PubMed ID: 19815302
   
  
• Genetic Evidence That the Differential Expression of the Ligand-Independent Isoform of CTLA-4 Is the Molecular Basis of the Idd5.1 Type 1 Diabetes Region in Nonobese Diabetic Mice.
  Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS
  J Immunol. 2009
  PubMed ID: 19783679
   
  
• Associations of the CTLA-4 polymorphisms with type 1 diabetes in a Chilean population: case-parent design.
  Angel B, Balic I, Santos JL, Codner E, Carrasco E, Pérez-Bravo F
  Diabetes Res Clin Pract. 2009
  PubMed ID: 19592124
   
  
• Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.
  Lempainen J, Vaarala O, Mäkelä M, Veijola R, Simell O, Knip M, Hermann R, Ilonen J
  J Autoimmun. 2009
  PubMed ID: 19473815
   
  
• Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?
  Bouwhuis MG, Gast A, Figl A, Eggermont AM, Hemminki K, Schadendorf D, Kumar R
  Cancer Immunol Immunother. 2009
  PubMed ID: 19672595
   
  
• CTLA-4 CT60 polymorphism in thyroid and polyglandular autoimmunity.
  Dultz G, Matheis N, Dittmar M, Bender K, Kahaly GJ
  Horm Metab Res. 2009
  PubMed ID: 19530270
   
  
• The CTLA4 +49 A/G polymorphism is not associated with susceptibility to type 1 diabetes mellitus in the Portuguese population.
  Lemos MC, Coutinho E, Gomes L, Bastos M, Fagulha A, Barros L, Carrilho F, Geraldes E, Regateiro FJ, Carvalheiro M
  Int J Immunogenet. 2009
  PubMed ID: 19490216
   
  
• [Association of CTLA-4 + 49A/G and CT60 gene polymorphism with type 1 diabetes and thyroid autoimmunity]
  Jin P, Xiang B, Lin J, Huang G, Zhou WD, Zheng C, Chao C, Zhou ZG
  Zhonghua Yi Xue Za Zhi. 2009
  PubMed ID: 19595177
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Cytotoxic T-lymphocyte antigen 4 gene polymorphisms are associated with latent autoimmune diabetes in adults.
  Douroudis K, Prans E, Kisand K, Nemvalts V, Uibo R
  Clin Chim Acta. 2009
  PubMed ID: 19332045
   
  
• Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates.
  Douroudis K, Laine AP, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K
  Hum Immunol. 2009
  PubMed ID: 19376178
   
  
• Type 1 diabetes susceptibility determined by HLA alleles and CTLA-4 and insulin genes polymorphisms in Brazilians.
  Ferreira AC, Gomes KB, Sampaio IB, de Oliveira VC, Pardini VC, Godard AL
  Arq Bras Endocrinol Metabol. 2009
  PubMed ID: 19578600
   
  
• [+49 A/G genetic polymorphism of cytotoxic T lymphocyte associated antigen 4 (CTLA-4) in type 7 diabetes: association with autoantibodies and cytokines]
  Pérez B F, Codner D E, Angel B B, Balic N I, Carrasco P E
  Rev Med Chil. 2009
  PubMed ID: 19621172
   
  
• Interactions between programmed death 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) gene polymorphisms in type 1 diabetes.
  Momin S, Flores S, Angel B B, Codner D E, Carrasco P E, Perez-Bravo F
  Diabetes Res Clin Pract. 2009
  PubMed ID: 19147248
   
  
• Do non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children with High-Risk HLA-DR,DQ Genotypes?
  Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ
  Diabetes. 2009
  PubMed ID: 19188433
   
  
• MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth.
  Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez ER, Walter M, Rosinger S, Ziegler A, Böhm BO, Diabetes Genetics Consortium
  Diabetes Obes Metab. 2009
  PubMed ID: 19143820
   
  
• Association of CTLA-4 polymorphisms and clinical-immunologic characteristics at onset of type 1 diabetes mellitus in children.
  Balic I, Angel B, Codner E, Carrasco E, Pérez-Bravo F
  Hum Immunol. 2009
  PubMed ID: 19136037
   
  
• AUTOIMMUNE THYROIDITIS AND DIABETES: DISSECTING THE JOINT GENETIC SUSCEPTIBILITY IN A LARGE COHORT OF MULTIPLEX FAMILIES.
  Villano MJ, Huber AK, Greenberg DA, Golden BK, Concepcion E, Tomer Y
  J Clin Endocrinol Metab. 2009
  PubMed ID: 19141582
   
  
• Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
  Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG
  BMC Med Genet. 2009
  PubMed ID: 19951419
   
  
• Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.
  Luczyński W, Wawrusiewicz-Kurylonek N, Stasiak-Barmuta A, Urban R, Iłendo E, Urban M, Hryszko M, Kretowski A, Górska M
  Acta Biochim Pol. 2009
  PubMed ID: 19547759
   
  
• Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.
  Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS
  J Immunol. 2009
  PubMed ID: 19109158
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  
• CD40 on NOD CD4 T cells contributes to their activation and pathogenicity.
  Baker RL, Wagner DH, Haskins K
  J Autoimmun. 2008
  PubMed ID: 18951762
   
  
• Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese.
  Awata T, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Nakanishi K, Kobayashi T, Iizuka H, Uga M, Kawabata Y, Kanazawa Y, Kurihara S, Osaki M, Katayama S, on behalf of the Japanese Study Group on Type 1 Diabetes Genetics
  J Clin Endocrinol Metab. 2008
  PubMed ID: 18940880
   
  
• Effect of HLA genotype or CTLA-4 polymorphism on cytokine response in healthy children.
  Walldén J, Ilonen J, Roivainen M, Ludvigsson J, Vaarala O, ABIS Study Group
  Scand J Immunol. 2008
  PubMed ID: 18782261
   
  
• Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
  Butty V, Campbell C, Mathis D, Benoist C, the Diabetes Prevention Trial-Type 1 Study Group
  Diabetes. 2008
  PubMed ID: 18556337
   
  
• CTLA-4 gene polymorphisms predispose to autoimmune endocrinopathies but not to celiac disease.
  Dallos T, Avbelj M, Barák L, Zapletalová J, Pribilincová Z, Krajcírová M, Kostálová L, Battelino T, Kovács L
  Neuro Endocrinol Lett. 2008
  PubMed ID: 18580850
   
  
• Differences in the Contribution of CTLA4 Gene to Susceptibility to Fulminant and Type 1A Diabetes in Japanese Patients.
  Kawasaki E, Imagawa A, Makino H, Uga M, Abiru N, Hanafusa T, Uchigata Y, Eguchi K
  Diabetes Care. 2008
  PubMed ID: 18443194
   
  
• Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.
  Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC
  Diabetologia. 2008
  PubMed ID: 18292987
   
  
• Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes.
  Hunter K, Rainbow D, Plagnol V, Todd JA, Peterson LB, Wicker LS
  J Immunol. 2007
  PubMed ID: 18056379
   
  
• Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
  Eising S, Svensson J, Skogstrand K, Nilsson A, Lynch K, Andersen PS, Lernmark A, Hougaard DM, Pociot F, Nørgaard-Pedersen B, Nerup J
  Paediatr Perinat Epidemiol. 2007
  PubMed ID: 17937736
   
  
• The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.
  Jonson CO, Lernmark A, Ludvigsson J, Rutledge EA, Hinkkanen A, Faresjö M
  Pediatr Diabetes. 2007
  PubMed ID: 17659059
   
  
• A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
  Howson JM, Dunger DB, Nutland S, Stevens H, Wicker LS, Todd JA
  Diabetologia. 2007
  PubMed ID: 17334650
   
  
• Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes.
  Payne F, Cooper JD, Walker NM, Lam AC, Smink LJ, Nutland S, Stevens HE, Hutchings J, Todd JA
  J Leukoc Biol. 2007
  PubMed ID: 17209142
   
  
• Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group.
  Haller K, Kisand K, Pisarev H, Salur L, Laisk T, Nemvalts V, Uibo R
  Tissue Antigens. 2007
  PubMed ID: 17257313
   
  
• No evidence of association of CTLA-4 -318 C/T, 159 C/T, 3' STR and SUMO4 163 AG polymorphism with autoimmune diabetes.
  Caputo M, Cerrone GE, Mazza C, Cédola N, Targovnik HM, Gustavo DF
  Immunol Invest. 2007
  PubMed ID: 17558709
   
  
• CT60 genotype does not affect CTLA-4 isoform expression despite association to T1D and AITD in northern Sweden.
  Mayans S, Lackovic K, Nyholm C, Lindgren P, Ruikka K, Eliasson M, Cilio CM, Holmberg D
  BMC Med Genet. 2007
  PubMed ID: 17280620
   
  
• Modeling CTLA4-linked autoimmunity with RNA interference in mice.
  Chen Z, Stockton J, Mathis D, Benoist C
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 17060611
   
  
• Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the Japanese.
  Kanazawa Y, Motohashi Y, Yamada S, Oikawa Y, Shigihara T, Okubo Y, Maruyama T, Shimada A
  Ann N Y Acad Sci. 2006
  PubMed ID: 17130562
   
  
• Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.
  Ikegami H, Fujisawa T, Kawabata Y, Noso S, Ogihara T
  Ann N Y Acad Sci. 2006
  PubMed ID: 17130532
   
  
• Functional evaluation of the autoimmunity-associated CTLA4 gene: the effect of the (AT) repeat in the 3'untranslated region (UTR).
  Anjos SM, Polychronakos C
  J Autoimmun. 2006
  PubMed ID: 16891094
   
  
• Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
  Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA
  J Clin Invest. 2006
  PubMed ID: 16886063
   
  
• The association of CTLA-4 and HLA class II autoimmune risk genotype with regulatory T cell marker expression in 5-year-old children.
  Jonson CO, Hedman M, Karlsson Faresjö M, Casas R, Ilonen J, Ludvigsson J, Vaarala O, ABIS Study Group
  Clin Exp Immunol. 2006
  PubMed ID: 16792673
   
  
• Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
  Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP
  J Allergy Clin Immunol. 2006
  PubMed ID: 16750991
   
  
• Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
  Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J
  Diabetologia. 2006
  PubMed ID: 16614815
   
  
• Promoter region -318 C/ T and -1661 A/G CTLA-4 single nucleotide polymorphisms and type 1 diabetes in North Indians.
  Baniasadi V, Narain N, Goswami R, Das SN
  Tissue Antigens. 2006
  PubMed ID: 16671945
   
  
• Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4.
  Ahmedov G, Ahmedova L, Sedlakova P, Cinek O
  Pediatr Diabetes. 2006
  PubMed ID: 16629714
   
  
• Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A.
  Sumnik Z, Cinek O, Bratanic N, Kordonouri O, Kulich M, Roszai B, Arato A, Lebl J, Soltesz G, Danne T, Battelino T, Schober E
  Diabetes Care. 2006
  PubMed ID: 16567828
   
  
• Antigen exposure during enhanced CTLA-4 expression promotes allograft tolerance in vivo.
  Salvalaggio PR, Camirand G, Ariyan CE, Deng S, Rogozinski L, Basadonna GP, Rothstein DM
  J Immunol. 2006
  PubMed ID: 16455985
   
  
• Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.
  Lundholm M, Motta V, Löfgren-Burström A, Duarte N, Bergman ML, Mayans S, Holmberg D
  Diabetes. 2006
  PubMed ID: 16443792
   
  
• No evidence of a significant role for CTLA-4 in multiple sclerosis.
  Roxburgh RH, Sawcer S, Maranian M, Seaman S, Hensiek A, Yeo T, Deans J, Compston A
  J Neuroimmunol. 2006
  PubMed ID: 16325273
   
  
• Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus.
  Felner EI, Klitz W, Ham M, Lazaro AM, Stastny P, Dupont B, White PC
  Pediatr Diabetes. 2005
  PubMed ID: 16390390
   
  
• Polymorphisms at +49A/G and CT60 sites in the 3' UTR of the CTLA-4 gene and APECED-related AIRE gene mutations analysis in sporadic idiopathic hypoparathyroidism.
  Goswami R, Gupta N, Ray D, Rani R, Tomar N, Sarin R, Vupputuri MR
  Int J Immunogenet. 2005
  PubMed ID: 16313305
   
  
• Haplotype tagging efficiency in worldwide populations in CTLA4 gene.
  Ramírez-Soriano A, Lao O, Soldevila M, Calafell F, Bertranpetit J, Comas D
  Genes Immun. 2005
  PubMed ID: 16034471
   
  
• Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.
  Purohit S, Podolsky R, Collins C, Zheng W, Schatz D, Muir A, Hopkins D, Huang YH, She JX
  J Autoimmune Dis. 2005
  PubMed ID: 16259622
   
  
• CTLA4 is differentially associated with autoimmune diseases in the Dutch population.
  Zhernakova A, Eerligh P, Barrera P, Wesoly JZ, Weseloy JZ, Huizinga TW, Roep BO, Wijmenga C, Koeleman BP
  Hum Genet. 2005
  PubMed ID: 16025348
   
  
• The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity.
  Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lähde J, Simell O, Knip M, Ilonen J
  Diabetologia. 2005
  PubMed ID: 16025255
   
  
• Association of non-HLA genes with type 1 diabetes autoimmunity.
  Steck AK, Bugawan TL, Valdes AM, Emery LM, Blair A, Norris JM, Redondo MJ, Babu SR, Erlich HA, Eisenbarth GS, Rewers MJ
  Diabetes. 2005
  PubMed ID: 16046318
   
  
• Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes.
  Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y
  J Clin Endocrinol Metab. 2005
  PubMed ID: 15928253
   
  
• CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis.
  Kavvoura FK, Ioannidis JP
  Am J Epidemiol. 2005
  PubMed ID: 15961581
   
  
• CTLA-4 gene polymorphisms and susceptibility to type 1 diabetes mellitus: a HuGE Review and meta-analysis.
  Kavvoura FK, Ioannidis JP
  Am J Epidemiol. 2005
  PubMed ID: 15961581
   
  
• CTLA-4 +49 A/G polymorphism is associated with predisposition to type 1 diabetes in Iranians.
  Mojtahedi Z, Omrani GR, Doroudchi M, Ghaderi A
  Diabetes Res Clin Pract. 2005
  PubMed ID: 15860238
   
  
• CBLB variants in type 1 diabetes and their genetic interaction with CTLA4.
  Bergholdt R, Taxvig C, Eising S, Nerup J, Pociot F
  J Leukoc Biol. 2005
  PubMed ID: 15629882
   
  
• Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry.
  Li-Sucholeiki XC, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler PM, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, Karger B, Gillespie KM, Ekstrøm PO, Todd JA, Thilly WG
  Mutat Res. 2005
  PubMed ID: 15708585
   
  
• IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance.
  Gregg RK, Bell JJ, Lee HH, Jain R, Schoenleber SJ, Divekar R, Zaghouani H
  J Immunol. 2005
  PubMed ID: 15634884
   
  
• Estimation of diabetes risk in Brazilian population by typing for polymorphisms in HLA-DR-DQ, INS and CTLA-4 genes.
  Hauache OM, Reis AF, Oliveira CS, Vieira JG, Sjöroos M, Ilonen J
  Dis Markers. 2005
  PubMed ID: 16276008
   
  
• Association of the cytotoxic T lymphocyte-associated antigen 4 gene with type 1 diabetes: evidence for independent effects of two polymorphisms on the same haplotype block.
  Anjos SM, Tessier MC, Polychronakos C
  J Clin Endocrinol Metab. 2004
  PubMed ID: 15579786
   
  
• Association between CTLA-4 +49 A/G polymorphism and type 1B diabetes in Japanese population.
  Liang H, Yagi K, Asano A, Kobayashi J, Mabuchi H
  Endocrine. 2004
  PubMed ID: 15711022
   
  
• Type 1 diabetes is insulin -2221 MspI and CTLA-4 +49 A/G polymorphism dependent.
  Haller K, Kisand K, Nemvalts V, Laine AP, Ilonen J, Uibo R
  Eur J Clin Invest. 2004
  PubMed ID: 15305888
   
  
• Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene.
  Zalloua PA, Abchee A, Shbaklo H, Zreik TG, Terwedow H, Halaby G, Azar ST
  Hum Immunol. 2004
  PubMed ID: 15301861
   
  
• Polymorphisms in the cytotoxic T lymphocyte antigen-4 gene region confer susceptibility to Addison's disease.
  Blomhoff A, Lie BA, Myhre AG, Kemp EH, Weetman AP, Akselsen HE, Huseby ES, Undlien DE
  J Clin Endocrinol Metab. 2004
  PubMed ID: 15240634
   
  
• Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse.
  Wicker LS, Chamberlain G, Hunter K, Rainbow D, Howlett S, Tiffen P, Clark J, Gonzalez-Munoz A, Cumiskey AM, Rosa RL, Howson JM, Smink LJ, Kingsnorth A, Lyons PA, Gregory S, Rogers J, Todd JA, Peterson LB
  J Immunol. 2004
  PubMed ID: 15210771
   
  
• Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen.
  Eggena MP, Walker LS, Nagabhushanam V, Barron L, Chodos A, Abbas AK
  J Exp Med. 2004
  PubMed ID: 15210748
   
  
• Analysis of cytotoxic T lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism in patients with type 1 diabetes mellitus in a Turkish population.
  Genc S, Genc K, Sercan O, Kizildag S, Gulay Z, Atay T, Dundar B, Sakizli M, Büyükgebiz A
  J Pediatr Endocrinol Metab. 2004
  PubMed ID: 15237707
   
  
• An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells.
  Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK
  Immunity. 2004
  PubMed ID: 15142525
   
  
• The emerging role of the CTLA-4 gene in autoimmune endocrinopathies.
  Vaidya B, Pearce S
  Eur J Endocrinol. 2004
  PubMed ID: 15132716
   
  
• Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis.
  Barton A, Jury F, Eyre S, Bowes J, Hinks A, Ward D, Worthington J
  Arthritis Rheum. 2004
  PubMed ID: 15022315
   
  
• Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes.
  Ide A, Kawasaki E, Abiru N, Sun F, Kobayashi M, Fukushima T, Takahashi R, Kuwahara H, Kita A, Oshima K, Uotani S, Yamasaki H, Yamaguchi Y, Eguchi K
  J Autoimmun. 2004
  PubMed ID: 14709415
   
  
• Coeliac disease: investigation of proposed causal variants in the CTLA4 gene region.
  King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ciclitira PJ
  Eur J Immunogenet. 2003
  PubMed ID: 14675397
   
  
• Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
  Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC
  Nature. 2003
  PubMed ID: 12724780
   
  
• Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
  Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîrgovişte C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC
  Nature. 2003
  PubMed ID: 12724780
   
  
• Association of the CTLA4 promoter region (-1661G allele) with type 1 diabetes in the South Moroccan population.
  Bouqbis L, Izaabel H, Akhayat O, Pérez-Lezaun A, Calafell F, Bertranpetit J, Comas D
  Genes Immun. 2003
  PubMed ID: 12618861
   
  
• Association of the CTLA-4 gene 49 A/G polymorphism with type 1 diabetes and autoimmune thyroid disease in Japanese children.
  Mochizuki M, Amemiya S, Kobayashi K, Kobayashi K, Shimura Y, Ishihara T, Nakagomi Y, Onigata K, Tamai S, Kasuga A, Nanazawa S
  Diabetes Care. 2003
  PubMed ID: 12610047
   
  
• CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen.
  Walker LS, Ausubel LJ, Chodos A, Bekarian N, Abbas AK
  J Immunol. 2002
  PubMed ID: 12444125
   
  
• CTLA-4-Ig regulates tryptophan catabolism in vivo.
  Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A, Candeloro P, Belladonna ML, Bianchi R, Fioretti MC, Puccetti P
  Nat Immunol. 2002
  PubMed ID: 12368911
   
  
• CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese.
  Ma Y, Tang X, Chang W, Gao L, Li M, Yan W
  Chin Med J (Engl). 2002
  PubMed ID: 12515273
   
  
• Association of CTLA-4 variation with type I diabetes in Filipinos.
  Klitz W, Bugawan TL, Panelo A, Solfelix CM, Buzzetti R, Pozzilli P, Steiner L, Alejandrino M, Erlich HA
  Immunogenetics. 2002
  PubMed ID: 12185534
   
  
• A recently described polymorphism in the CD28 gene on chromosome 2q33 is not associated with susceptibility to type 1 diabetes.
  Wood JP, Pani MA, Bieda K, Meyer G, Usadel KH, Badenhoop K
  Eur J Immunogenet. 2002
  PubMed ID: 12121283
   
  
• Locally expressed CTLA4-Ig in a pancreatic beta-cell line suppresses accelerated graft rejection response induced by donor-specific transfusion.
  Kimura F, Gotoh M, Tanaka T, Luo Z, Miyazaki J, Uede T, Monden M, Miyasaka M
  Diabetologia. 2002
  PubMed ID: 12107727
   
  
• CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect.
  Fajardy I, Vambergue A, Stuckens C, Weill J, Danze PM, Fontaine P
  Eur J Immunogenet. 2002
  PubMed ID: 12047362
   
  
• The CTLA4 +49 A/G dimorphism is not associated with type 1 diabetes in Czech children.
  Cinek O, Drevínek P, Sumník Z, Bendlová B, Kolousková S, Snajderová M, Vavrinec J
  Eur J Immunogenet. 2002
  PubMed ID: 12047357
   
  
• Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
  Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day HL, Landin-Olsson M, Palmer JP, Janer-Villanueva M, Hood L, Sundkvist G, Lernmark A, Breslow N, Dahlquist G, Blohmé G, Diabetes Incidence in Sweden Study Group, Swedish Childhood Diabetes Study Group
  Diabetes. 2002
  PubMed ID: 11978629
   
  
• CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults.
  Cosentino A, Gambelunghe G, Tortoioli C, Falorni A
  Ann N Y Acad Sci. 2002
  PubMed ID: 12021137
   
  
• An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies.
  Vaidya B, Pearce SH, Charlton S, Marshall N, Rowan AD, Griffiths ID, Kendall-Taylor P, Cawston TE, Young-Min S
  Rheumatology (Oxford). 2002
  PubMed ID: 11886967
   
  
• IDD3 and IDD5 alleles from nod mice mediate Sjögren's syndrome-like autoimmunity.
  Cha S, Nagashima H, Peck AB, Humphreys-Beher MG
  Adv Exp Med Biol. 2002
  PubMed ID: 12614028
   
  
• The study of CTLA-4 and vitamin D receptor polymorphisms in the Romanian type 1 diabetes population.
  Guja C, Marshall S, Welsh K, Merriman M, Smith A, Todd JA, Ionescu-Tîrgoviste C
  J Cell Mol Med. 2002
  PubMed ID: 12003670
   
  
• Markers for risk of type 1 diabetes in relatives of Alsacian patients with type 1 diabetes.
  Ongagna JC, Sapin R, Pinget M, Belcourt A
  Int J Exp Diabetes Res. 2002
  PubMed ID: 11900275
   
  
• Role of the B7-CD28/CTLA-4 pathway in autoimmune disease.
  Chang TT, Kuchroo VK, Sharpe AH
  Curr Dir Autoimmun. 2002
  PubMed ID: 11826754
   
  
• [Association between type 1 diabetes and polymorphism of the CTLA-4 gene in a Tunisian population]
  Kamoun Abid H, Hmida S, Smaoui N, Kaabi H, Abid A, Chaabouni H, Boukef K, Nagati K
  Pathol Biol (Paris). 2001
  PubMed ID: 11776689
   
  
• Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.
  Lamhamedi-Cherradi SE, Boulard O, Gonzalez C, Kassis N, Damotte D, Eloy L, Fluteau G, Lévi-Strauss M, Garchon HJ
  Diabetes. 2001
  PubMed ID: 11723074
   
  
• CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody.
  Abe T, Yamaguchi Y, Takino H, Fujita N, Yamauchi-Degawa M, Ozaki M, Yamakawa K, Sera Y, Sakamaki H, Uotani S, Kawasaki E, Awata T, Yamasaki H, Eguchi K
  Diabet Med. 2001
  PubMed ID: 11606170
   
  
• Association of a novel point mutation (C159G) of the CTLA4 gene with type 1 diabetes in West Africans but not in Chinese.
  Osei-Hyiaman D, Hou L, Zhiyin R, Zhiming Z, Yu H, Amankwah AA, Harada S
  Diabetes. 2001
  PubMed ID: 11522687
   
  
• Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with type 1 diabetes in the Japanese population.
  Ihara K, Ahmed S, Nakao F, Kinukawa N, Kuromaru R, Matsuura N, Iwata I, Nagafuchi S, Kohno H, Miyako K, Hara T
  Immunogenetics. 2001
  PubMed ID: 11685455
   
  
• Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population.
  McCormack RM, Maxwell AP, Carson D, Patterson CC, Bingham A, Savage DA
  Genes Immun. 2001
  PubMed ID: 11477480
   
  
• The promoter region of the CTLA4 gene is associated with type 1 diabetes mellitus.
  Lee YJ, Lo FS, Shu SG, Wang CH, Huang CY, Liu HF, Wu CC, Yang TY, Chang JG
  J Pediatr Endocrinol Metab. 2001
  PubMed ID: 11327371
   
  
• CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice.
  Bergman ML, Cilio CM, Penha-Gonçalves C, Lamhamedi-Cherradi SE, Löfgren A, Colucci F, Lejon K, Garchon HJ, Holmberg D
  J Autoimmun. 2001
  PubMed ID: 11247636
   
  
• The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus.
  Rau H, Braun J, Donner H, Seissler J, Siegmund T, Usadel KH, Badenhoop K
  J Clin Endocrinol Metab. 2001
  PubMed ID: 11158025
   
  
• Prevalence of CTLA-4 polymorphism A49G in Ashkenazi Jews.
  Mack R, Chowdary D, Samaan P, Podolak I, Dermody J
  Genet Test. 2001
  PubMed ID: 11788096
   
  
• No association of type 1 diabetes with a microsatellite marker for CTLA-4 in a Japanese population.
  Ban Y, Taniyama M, Tozaki T, Yanagawa T, Yamada S, Maruyama T, Kasuga A, Tomita M, Ban Y
  Autoimmunity. 2001
  PubMed ID: 11681491
   
  
• CTLA4 gene polymorphisms are associated with, and linked to, insulin-dependent diabetes mellitus in a Russian population.
  Chistiakov DA, Savost'anov KV, Nosikov VV
  BMC Genet. 2001
  PubMed ID: 11286636
   
  
• Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
  Luhder F, Chambers C, Allison JP, Benoist C, Mathis D
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 11035773
   
  
• The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders.
  Naluai AT, Nilsson S, Samuelsson L, Gudjónsdóttir AH, Ascher H, Ek J, Hallberg B, Kristiansson B, Martinsson T, Nerman O, Sollid LM, Wahlström J
  Tissue Antigens. 2000
  PubMed ID: 11098935
   
  
• The length of the CTLA-4 microsatellite (AT)N-repeat affects the risk for type 1 diabetes. Diabetes Incidence in Sweden Study Group.
  Lowe RM, Graham J, Sund G, Kockum I, Landin-Olsson M, Schaefer JB, Törn C, Lernmark A, Dahlquist G
  Autoimmunity. 2000
  PubMed ID: 11092697
   
  
• NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
  Hill NJ, Lyons PA, Armitage N, Todd JA, Wicker LS, Peterson LB
  Diabetes. 2000
  PubMed ID: 11016460
   
  
• Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathy.
  Brayer J, Lowry J, Cha S, Robinson CP, Yamachika S, Peck AB, Humphreys-Beher MG
  J Rheumatol. 2000
  PubMed ID: 10955330
   
  
• CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis.
  Agarwal K, Jones DE, Daly AK, James OF, Vaidya B, Pearce S, Bassendine MF
  J Hepatol. 2000
  PubMed ID: 10782900
   
  
• Low CD86 expression in the nonobese diabetic mouse results in the impairment of both T cell activation and CTLA-4 up-regulation.
  Dahlén E, Hedlund G, Dawe K
  J Immunol. 2000
  PubMed ID: 10679081
   
  
• Genetics of autoimmune diabetes in animal models.
  McDuffie M
  Curr Opin Immunol. 1998
  PubMed ID: 9914220
   
  
• No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies.
  Heward JM, Allahabadia A, Carr-Smith J, Daykin J, Cockram CS, Gordon C, Barnett AH, Franklyn JA, Gough SC
  Clin Endocrinol (Oxf). 1998
  PubMed ID: 9861324
   
  
• CTLA-4 promoter variants in patients with Graves' disease and Hashimoto's thyroiditis.
  Braun J, Donner H, Siegmund T, Walfish PG, Usadel KH, Badenhoop K
  Tissue Antigens. 1998
  PubMed ID: 9672157
   
  
• Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups.
  Marron MP, Raffel LJ, Garchon HJ, Jacob CO, Serrano-Rios M, Martinez Larrad MT, Teng WP, Park Y, Zhang ZX, Goldstein DR, Tao YW, Beaurain G, Bach JF, Huang HS, Luo DF, Zeidler A, Rotter JI, Yang MC, Modilevsky T, Maclaren NK, She JX
  Hum Mol Genet. 1997
  PubMed ID: 9259273
   
  
• The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry.
  Nisticò L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, Bosi E, Larrad MT, Rios MS, Chow CC, Cockram CS, Jacobs K, Mijovic C, Bain SC, Barnett AH, Vandewalle CL, Schuit F, Gorus FK, Tosi R, Pozzilli P, Todd JA
  Hum Mol Genet. 1996
  PubMed ID: 8817351
   
  

Publications: 802

• [Single nucleotide polymorphisms of CTLA4 gene and their association with human cervical cancer].
  Jiang L, Luo RY, Zhang W, Wang LR, Wang F, Cheng YX
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011
  PubMed ID: 21644231
   
  
• Analysis of CTLA4 gene variant in infertile Brazilian women with and without endometriosis.
  Lerner TG, Bianco B, Teles JS, Vilarino FL, Christofolini DM, Barbosa CP
  Int J Immunogenet. 2011
  PubMed ID: 21599853
   
  
• Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo.
  Rudolph M, Hebel K, Miyamura Y, Maverakis E, Brunner-Weinzierl MC
  J Immunol. 2011
  PubMed ID: 21478403
   
  
• Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of rapamycin therapy prolongs free flap allograft survival.
  Xiao B, Xia W, Zhao K, Yang Y, Fu S, Li Y, Liu B, Guo S
  Plast Reconstr Surg. 2011
  PubMed ID: 21532411
   
  
• Genetic variants in CTLA4 are strongly associated with alopecia areata.
  John KK, Brockschmidt FF, Redler S, Herold C, Hanneken S, Eigelshoven S, Giehl KA, De Weert J, Lutz G, Kruse R, Wolff H, Blaumeiser B, Böhm M, Becker T, Nöthen MM, Betz RC
  J Invest Dermatol. 2011
  PubMed ID: 21346773
   
  
• Association of cytotoxic T lymphocyte associated antigen-4 gene (rs60872763) polymorphism with Crohn's disease and high levels of serum sCTLA-4 in Crohn's disease.
  Chen Z, Zhou F, Huang S, Jiang T, Chen L, Ge L, Xia B
  J Gastroenterol Hepatol. 2011
  PubMed ID: 21251066
   
  
• Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4.
  Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM
  Science. 2011
  PubMed ID: 21474713
   
  
• Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population.
  Kim HJ, Chung JH, Kang S, Kim SK, Cho BS, Kim SD, Hahn WH
  J Genet. 2011
  PubMed ID: 21677403
   
  
• Association between T-lymphocyte regulatory gene CTLA4 single nucleotide polymorphism at position 49 in exon 1 and HLA-DRB1*08 in Japanese patients with psoriasis vulgaris.
  Muto M, Deguchi H, Tanaka A, Inoue T, Ichimiya M
  J Dermatol Sci. 2011
  PubMed ID: 21316924
   
  
• CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population.
  Wu Q, Zhan X, Dou T, Chen H, Fan W, Zhou K, Zhang H, Zheng H, Cai Y, Zhao Y, Huang F, Zhou L, Mao Y, Lu D
  Biochem Genet. 2011
  PubMed ID: 21165767
   
  
• Haplotype analysis of CTLA4 gene and risk of esophageal squamous cell carcinoma in Anyang area of China.
  Cheng XL, Ning T, Xu CQ, Li Y, Zhu BS, Hou FT, Zhang SY, Chen ZP
  Hepatogastroenterology. 2011
  PubMed ID: 21661409
   
  
• CTLA-4 (CD152) blockade does not cause a pro-inflammatory cytokine profile in regulatory T cells.
  Kolar P, Hoff H, Maschmeyer P, Burmester GR, Brunner-Weinzierl MC
  Clin Exp Rheumatol. 2011
  PubMed ID: 21418778
   
  
• Immunoregulatory gene polymorphisms in women with preeclampsia.
  Pendeloski KP, Sass N, Torloni MR, Mattar R, Moron AF, Franchim CS, Daher S
  Hypertens Res. 2011
  PubMed ID: 21160481
   
  
• Rigid-body ligand recognition drives cytotoxic T-lymphocyte antigen 4 (CTLA-4) receptor triggering.
  Yu C, Sonnen AF, George R, Dessailly BH, Stagg LJ, Evans EJ, Orengo CA, Stuart DI, Ladbury JE, Ikemizu S, Gilbert RJ, Davis SJ
  J Biol Chem. 2011
  PubMed ID: 21156796
   
  
• Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
  Pedicord VA, Montalvo W, Leiner IM, Allison JP
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21173239
   
  
• CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation.
  Wang XB, Fan ZZ, Anton D, Vollenhoven AV, Ni ZH, Chen XF, Lefvert AK
  BMC Immunol. 2011
  PubMed ID: 21414236
   
  
• Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.
  Botturi K, Lacoeuille Y, Cavaillès A, Vervloet D, Magnan A
  Respir Res. 2011
  PubMed ID: 21356099
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• (AT) repeat in the 3' untranslated region of the CTLA-4 gene and susceptibility to acute allograft rejection in Tunisian renal transplantation.
  Krichen H, Sfar I, Hadj Kacem H, Bardi R, Jendoubi-Ayed S, Makhlouf M, Ben Romdhane T, Besseghair F, Aouadi H, Ben Abdallah T, Ayadi H, Ayed K, Gorgi Y
  Transplant Proc. 2010
  PubMed ID: 21168689
   
  
• [CTLA-4 gene polymorphism regulates CTLA-4 mRNA stability and protein level in patients with ulcerative colitis].
  Chen ZT, Xia B, Jiang T, Zhou F, Zou KF, Ge LQ
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010
  PubMed ID: 21154316
   
  
• Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative colitis.
  Jiang T, Ge LQ, Chen ZT, Li C, Zhou F, Luo Y, Xia B
  J Dig Dis. 2010
  PubMed ID: 21091900
   
  
• Association of genetic polymorphisms and risk of late post-transplantation infection in pediatric heart recipients.
  Ohmann EL, Brooks MM, Webber SA, Girnita DM, Ferrell RE, Burckart GJ, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi A
  J Heart Lung Transplant. 2010
  PubMed ID: 20869265
   
  
• Genetically determined amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.
  Sanchez E, Webb RD, Rasmussen A, Kelly JA, Riba L, Kaufman KM, Garcia-de la Torre I, Moctezuma JF, Maradiaga-Ceceña MA, Cardiel-Rios MH, Acevedo E, Cucho-Venegas M, Garcia MA, Gamron S, Pons-Estel BA, Vasconcelos C, Martin J, Tusié-Luna T, Harley JB, Richardson B, Sawalha AH, Alarcón-Riquelme ME
  Arthritis Rheum. 2010
  PubMed ID: 20848568
   
  
• Increased CTLA-4 and FOXP3 transcripts in peripheral blood mononuclear cells of patients with breast cancer.
  Jaberipour M, Habibagahi M, Hosseini A, Habibabad SR, Talei A, Ghaderi A
  Pathol Oncol Res. 2010
  PubMed ID: 20306312
   
  
• Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP.
  Birlea SA, Jin Y, Bennett DC, Herbstman DM, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Fain PR, Spritz RA
  J Invest Dermatol. 2010
  PubMed ID: 21085187
   
  
• CTLA-4, Position 49 A/G Polymorphism Associated with Coronary Artery Lesions in Kawasaki Disease.
  Kuo HC, Liang CD, Yu HR, Wang CL, Lin IC, Liu CA, Chang JC, Lee CP, Chang WC, Yang KD
  J Clin Immunol. 2010
  PubMed ID: 21082224
   
  
• Effect of donor CTLA-4 alleles and haplotypes on graft-versus-host disease occurrence in Tunisian patients receiving a human leukocyte antigen-identical sibling hematopoietic stem cell transplant.
  Sellami MH, Bani M, Torjemane L, Kaabi H, Ladeb S, Othmane TB, Hmida S
  Hum Immunol. 2010
  PubMed ID: 21081144
   
  
• Analysis of Immune Regulatory Genes' Copy Number Variants in Graves' Disease.
  Huber AK, Concepcion ES, Gandhi A, Menconi F, Smith EP, Keddache M, Tomer Y
  Thyroid. 2010
  PubMed ID: 21054240
   
  
• ICOS gene polymorphism may be associated with pemphigus.
  Narbutt J, Lesiak A, Klich I, Torzecka JD, Sysa-Jedrzejowska A, Młynarski W
  J Cutan Med Surg. 2010
  PubMed ID: 21084022
   
  
• IL1/IL1 Ra, CTLA-4 and Apo1/Fas genes polymorphisms and susceptibility to IgA nephropathy in Tunisian patients.
  Gorgi Y, Sfar I, Goucha R, Aouadi H, Amri M, Makhlouf M, Ben Romdhane T, Cherif M, Jendoubi-Ayed S, Ben Abdallah T, Ayed K
  Tunis Med. 2010
  PubMed ID: 21049406
   
  
• CTLA4 and CD86 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.
  Liu Y, Liang WB, Gao LB, Pan XM, Chen TY, Wang YY, Xue H, Zhang LS, Zhang L
  Hum Immunol. 2010
  PubMed ID: 20732370
   
  
• New insights of CTLA-4 into its biological function in breast cancer.
  Mao H, Zhang L, Yang Y, Zuo W, Bi Y, Gao W, Deng B, Sun J, Shao Q, Qu X
  Curr Cancer Drug Targets. 2010
  PubMed ID: 20578982
   
  
• CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population.
  Liu J, Li J, Li T, Wang T, Li Y, Zeng Z, Li Z, Chen P, Hu Z, Zheng L, Ji J, Feng G, Shi Y
  Brain Behav Immun. 2010
  PubMed ID: 21040781
   
  
• Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population.
  Li H, Ge J, Zhao H, Du W, Xu J, Sui T, Ma L, Zhou Z, Qi A, Yang R
  Platelets. 2010
  PubMed ID: 21034161
   
  
• Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
  Arthritis Rheum. 2010
  PubMed ID: 20973039
   
  
• Polymorphisms of the CTLA4 gene and kidney transplant rejection in Korean patients.
  Kim HJ, Jeong KH, Lee SH, Moon JY, Lee TW, Kang SW, Park SJ, Kim YH, Chung JH
  Transpl Immunol. 2010
  PubMed ID: 20940051
   
  
• CTLA-4 is expressed by human monocyte-derived dendritic cells and regulates their functions.
  Laurent S, Carrega P, Saverino D, Piccioli P, Camoriano M, Morabito A, Dozin B, Fontana V, Simone R, Mortara L, Mingari MC, Ferlazzo G, Pistillo MP
  Hum Immunol. 2010
  PubMed ID: 20650297
   
  
• Elevated mRNA levels of CTLA-4, FoxP3, and granzyme B in BAL, but not in blood, during acute rejection of lung allografts.
  Madsen CB, Nørgaard A, Iversen M, Ryder LP
  Transpl Immunol. 2010
  PubMed ID: 20633650
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• ctla-4 gene variations may influence cervical cancer susceptibility.
  Rahimifar S, Erfani N, Sarraf Z, Ghaderi A
  Gynecol Oncol. 2010
  PubMed ID: 20615526
   
  
• Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
  Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
  Mol Hum Reprod. 2010
  PubMed ID: 20587610
   
  
• Circulating soluble CTLA4 (sCTLA4) is elevated in patients with breast cancer.
  Erfani N, Razmkhah M, Ghaderi A
  Cancer Invest. 2010
  PubMed ID: 20482250
   
  
• Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
  Webb R, Kelly JA, Somers EC, Hughes T, Kaufman KM, Sanchez E, Nath SK, Bruner G, Alarcón-Riquelme ME, Gilkeson GS, Kamen DL, Richardson BC, Harley JB, Sawalha AH
  Ann Rheum Dis. 2010
  PubMed ID: 20881011
   
  
• Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.
  Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T
  Immunity. 2010
  PubMed ID: 20870175
   
  
• Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20716621
   
  
• CTLA4 CT60 A/G gene polymorphism in liver transplant recipients.
  Azarpira N, Malekhosseini SA, Aghdaie MH, Daraie M
  Exp Clin Transplant. 2010
  PubMed ID: 20716038
   
  
• Association analysis of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with primary biliary cirrhosis in Japanese patients.
  Joshita S, Umemura T, Yoshizawa K, Katsuyama Y, Tanaka E, Nakamura M, Ishibashi H, Ota M, Shinshu PBC Study Group
  J Hepatol. 2010
  PubMed ID: 20557968
   
  
• Genetic variants in the prediction of rheumatoid arthritis.
  van der Helm-van Mil AH, Toes RE, Huizinga TW
  Ann Rheum Dis. 2010
  PubMed ID: 20439292
   
  
• The cytotoxic lymphocyte antigen 4 polymorphisms affect response to hepatitis C virus-specific therapy in HIV(+) patients with acute and chronic hepatitis C virus co-infection.
  Nischalke HD, Vogel M, Mauss S, Baumgarten A, Lutz T, Danta M, Naumann U, Coenen M, Sauerbruch T, Rockstroh JK, Spengler U, Nattermann J
  AIDS. 2010
  PubMed ID: 20588168
   
  
• [Expression and significance of gp96 and immune-related gene CTLA-4, CD8 in lung cancer tissues].
  Zheng H, Li Y, Wang X, Zhang X, Wang X
  Zhongguo Fei Ai Za Zhi. 2010
  PubMed ID: 20704820
   
  
• [Association of CTLA4 gene +49G/A polymorphism with HBV infection and HBV-related hepatocellular carcinoma in Hunan Han population].
  Liu G, Lu GX
  Nan Fang Yi Ke Da Xue Xue Bao. 2010
  PubMed ID: 20813679
   
  
• Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.
  Beckers MM, Ruven HJ, Haas FJ, Doevendans PA, ten Cate H, Prins MH, Biesma DH
  Eur J Intern Med. 2010
  PubMed ID: 20603037
   
  
• Cutting edge: CTLA-4--B7 interaction suppresses Th17 cell differentiation.
  Ying H, Yang L, Qiao G, Li Z, Zhang L, Yin F, Xie D, Zhang J
  J Immunol. 2010
  PubMed ID: 20601598
   
  
• Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
  Plant D, Flynn E, Mbarek H, Dieudé P, Cornelis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Johansen JS, Ørnbjerg LM, Hetland ML, Klareskog L, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Worthington J
  Ann Rheum Dis. 2010
  PubMed ID: 20498205
   
  
• Genetic polymorphisms of the T-cell coreceptors CD28 and CTLA-4 in Afro- and Euro-Brazilians.
  Pincerati MR, Dalla-Costa R, Pavoni DP, Petzl-Erler ML
  Int J Immunogenet. 2010
  PubMed ID: 20477885
   
  
• Polymorphisms in the 2q33 and 3q21 chromosome regions including T-cell coreceptor and ligand genes may influence susceptibility to pemphigus foliaceus.
  Dalla-Costa R, Pincerati MR, Beltrame MH, Malheiros D, Petzl-Erler ML
  Hum Immunol. 2010
  PubMed ID: 20433886
   
  
• Cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphism in patients with Behçet's disease.
  Düzgün N, Duman T, Keskin O, Morris Y, Tutkak H
  Clin Exp Rheumatol. 2010
  PubMed ID: 20868585
   
  
• Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
  Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM
  Nature. 2010
  PubMed ID: 20596022
   
  
• Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction.
  Juran BD, Atkinson EJ, Larson JJ, Schlicht EM, Liu X, Heathcote EJ, Hirschfield GM, Siminovitch KA, Lazaridis KN
  Hepatology. 2010
  PubMed ID: 20578265
   
  
• The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients.
  Kusztal M, Kościelska-Kasprzak K, Drulis-Fajdasz D, Magott-Procelewska M, Patrzałek D, Janczak D, Chudoba P, Klinger M
  Transpl Immunol. 2010
  PubMed ID: 20470888
   
  
• A Large-scale genetic association study of esophageal adenocarcinoma risk.
  Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
  Carcinogenesis. 2010
  PubMed ID: 20453000
   
  
• Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma.
  Kämmerer PW, Toyoshima T, Schöder F, Kämmerer P, Kuhr K, Brieger J, Al-Nawas B
  Oral Oncol. 2010
  PubMed ID: 20435510
   
  
• Association of CT60 cytotoxic T lymphocyte antigen-4 gene polymorphism with thyroid autoantibody production in patients with Hashimoto's and postpartum thyroiditis.
  Zaletel K, Krhin B, Gaberscek S, Bicek A, Pajic T, Hojker S
  Clin Exp Immunol. 2010
  PubMed ID: 20408864
   
  
• Circulating soluble CTLA-4 is related to inflammatory markers in the 70 year old population.
  Sakthivel P, Wermeling F, Elmgren A, Hulthe J, Kakoulidou M, Lefvert AK, Lind L
  Scand J Clin Lab Invest. 2010
  PubMed ID: 20331384
   
  
• CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer.
  Hu L, Liu J, Chen X, Zhang Y, Liu L, Zhu J, Chen J, Shen H, Qiang F, Hu Z
  Hum Immunol. 2010
  PubMed ID: 20538028
   
  
• Domain metastability: a molecular basis for immunoglobulin deposition?
  Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ
  J Mol Biol. 2010
  PubMed ID: 20394753
   
  
• Investigation of CTLA-4 and CD28 gene polymorphisms in patients with diabetes mellitus type 2 using PCR-RFLP in a Turkish population.
  Uzer E, Dilmec F, Akkafa F, Boduroglu O, van Kuilenburg AB
  West Indian Med J. 2010
  PubMed ID: 21291098
   
  
• Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
  Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
  Pediatr Pulmonol. 2010
  PubMed ID: 20503287
   
  
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
  Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
  Nat Genet. 2010
  PubMed ID: 20453842
   
  
• Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
  Tan RJ, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, BRAGGSS, Barton A
  Ann Rheum Dis. 2010
  PubMed ID: 20444755
   
  
• Surfactant protein D-mediated decrease of allergen-induced inflammation is dependent upon CTLA4.
  Lin KW, Jen KY, Suarez CJ, Crouch EC, Perkins DL, Finn PW
  J Immunol. 2010
  PubMed ID: 20435925
   
  
• CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch.
  Hoff H, Kolar P, Ambach A, Radbruch A, Brunner-Weinzierl MC
  Mol Immunol. 2010
  PubMed ID: 20417562
   
  
• Replication of genetic association studies in asthma and related phenotypes.
  Undarmaa S, Mashimo Y, Hattori S, Shimojo N, Fujita K, Miyatake A, Doi S, Kohno Y, Okamoto Y, Hirota T, Tamari M, Hata A, Suzuki Y
  J Hum Genet. 2010
  PubMed ID: 20395963
   
  
• Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.
  Sombekke MH, Arteta D, van de Wiel MA, Crusius JB, Tejedor D, Killestein J, Martínez A, Peña AS, Polman CH, Uitdehaag BM
  Mult Scler. 2010
  PubMed ID: 20378664
   
  
• A screen for endocytic motifs.
  Kozik P, Francis RW, Seaman MN, Robinson MS
  Traffic. 2010
  PubMed ID: 20214754
   
  
• CTLA-4 +49A>G polymorphism of recipients of HLA-matched sibling allogeneic stem cell transplantation is associated with survival and relapse incidence.
  Piccioli P, Balbi G, Serra M, Morabito A, Lamparelli T, Gobbi M, Laurent S, Dozin B, Bruzzi P, Ferraris AM, Bacigalupo A, Notaro R, Pistillo MP
  Ann Hematol. 2010
  PubMed ID: 20020126
   
  
• CTLA4 CT60 Single-Nucleotide Polymorphism Is Associated with Slovenian Inflammatory Bowel Disease Patients and Regulates Expression of CTLA4 Isoforms.
  Repnik K, Potočnik U
  DNA Cell Biol. 2010
  PubMed ID: 20491567
   
  
• T cell pathways involving CTLA4 contribute to a model of acute lung injury.
  Nakajima T, Suarez CJ, Lin KW, Jen KY, Schnitzer JE, Makani SS, Parker N, Perkins DL, Finn PW
  J Immunol. 2010
  PubMed ID: 20385880
   
  
• CTLA4 -1661A/G and 3'UTR long repeat polymorphisms are associated with ulcerative colitis and influence CTLA4 mRNA and protein expression.
  Chen Z, Brant SR, Li C, Shrestha UK, Jiang T, Zhou F, Jiang Y, Shi X, Zhao Y, Li J, Xia B
  Genes Immun. 2010
  PubMed ID: 20445568
   
  
• The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population.
  Muñoz-Valle JF, Valle Y, Padilla-Gutiérrez JR, Parra-Rojas I, Rangel-Villalobos H, Vázquez del Mercado M, Ledezma-Lozano IY, Villafan-Bernal JR, Armendáriz-Borunda J, Pereira-Suárez AL
  Clin Chim Acta. 2010
  PubMed ID: 20138855
   
  
• [The analysis of 49A/G CTLA4 gene polymorphism association with development of allergic rhinitis].
  Alieva VSh, Karimov KhIa, Nazarov AA, Arifov SS, Boboev KT
  Tsitol Genet. 2010
  PubMed ID: 20608155
   
  
• Genetic markers in acquired haemophilia.
  Oldenburg J, Zeitler H, Pavlova A
  Haemophilia. 2010
  PubMed ID: 20586801
   
  
• CD4+CD25+Foxp3+ regulatory T cells optimize diversity of the conventional T cell repertoire during reconstitution from lymphopenia.
  Winstead CJ, Reilly CS, Moon JJ, Jenkins MK, Hamilton SE, Jameson SC, Way SS, Khoruts A
  J Immunol. 2010
  PubMed ID: 20357265
   
  
• Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
  Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
  J Infect Dis. 2010
  PubMed ID: 20331378
   
  
• Independent predictive roles of eotaxin Ala23Thr, paraoxonase 2 Ser311Cys and beta-adrenergic receptor Trp64Arg polymorphisms on cardiac disease in Type 2 Diabetes--an 8-year prospective cohort analysis of 1297 patients.
  Wang Y, Luk AO, Ma RC, So WY, Tam CH, Ng MC, Yang X, Baum L, Lam V, Tong PC, Chan JC
  Diabet Med. 2010
  PubMed ID: 20536507
   
  
• Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma.
  Oh KY, Kang MJ, Choi WA, Kwon JW, Kim BJ, Yu J, Hong SJ
  Allergy Asthma Immunol Res. 2010
  PubMed ID: 20358027
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Multiple common variants for celiac disease influencing immune gene expression.
  Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
  Nat Genet. 2010
  PubMed ID: 20190752
   
  
• HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians.
  Coppo P, Busson M, Veyradier A, Wynckel A, Poullin P, Azoulay E, Galicier L, Loiseau P, French Reference Centre For Thrombotic Microangiopathies
  J Thromb Haemost. 2010
  PubMed ID: 20141578
   
  
• Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia.
  Chua KH, Puah SM, Chew CH, Tan SY, Lian LH
  Ann Hum Biol. 2010
  PubMed ID: 19951233
   
  
• HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease.
  Takahashi M, Kimura A
  J Hum Genet. 2010
  PubMed ID: 20300120
   
  
• Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
  Karlson EW, Chibnik LB, Kraft P, Cui J, Keenan BT, Ding B, Raychaudhuri S, Klareskog L, Alfredsson L, Plenge RM
  Ann Rheum Dis. 2010
  PubMed ID: 20233754
   
  
• The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
  Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, Farragher T, Bunn D, Worthington J, Symmons D, Barton A
  Rheumatology (Oxford). 2010
  PubMed ID: 20219786
   
  
• PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
  Curran MA, Montalvo W, Yagita H, Allison JP
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20160101
   
  
• Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis.
  Kim YO, Kim HJ, Kim SK, Chung JH, Hong SJ
  Clin Chem Lab Med. 2010
  PubMed ID: 20113255
   
  
• Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population.
  Chen DQ, Zeng Y, Zhou J, Yang L, Jiang S, Huang JD, Lu L, Zheng BJ
  J Med Virol. 2010
  PubMed ID: 20087947
   
  
• Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
  Hinks A, Eyre S, Ke X, Barton A, Martin P, Flynn E, Packham J, Worthington J, Childhood Arthritis Prospective Study, UKRAG Consortium, BSPAR Study Group, Thomson W
  Genes Immun. 2010
  PubMed ID: 20072139
   
  
• Association of CTLA4 gene polymorphism in Iranian patients with ankylosing spondylitis.
  Azizi E, Massoud A, Amirzargar AA, Mahmoudi M, Soleimanifar N, Rezaei N, Jamshidi AR, Nikbin B, Nicknam MH
  J Clin Immunol. 2010
  PubMed ID: 20012554
   
  
• Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer.
  Ivansson EL, Juko-Pecirep I, Gyllensten UB
  Gynecol Oncol. 2010
  PubMed ID: 19959217
   
  
• Functional polymorphism in CTLA4 gene influences the response to therapy with inhaled corticosteroids in Slovenian children with atopic asthma.
  Berce V, Potocnik U
  Biomarkers. 2010
  PubMed ID: 19895365
   
  
• Evidence for CTLA4 as a susceptibility gene for dilated cardiomyopathy.
  Ruppert V, Meyer T, Struwe C, Petersen J, Perrot A, Posch MG, Ozcelik C, Richter A, Maisch B, Pankuweit S
  Eur J Hum Genet. 2010
  PubMed ID: 20145677
   
  
• Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.
  Poirier N, Azimzadeh AM, Zhang T, Dilek N, Mary C, Nguyen B, Tillou X, Wu G, Reneaudin K, Hervouet J, Martinet B, Coulon F, Allain-Launay E, Karam G, Soulillou JP, Pierson RN, Blancho G, Vanhove B
  Sci Transl Med. 2010
  PubMed ID: 20371478
   
  
• [Interactions between susceptible genes and risk environmental factors in Chinese females with systemic lupus erythematosus]
  Peng CL, Jiang F, Wang BT, Yang XH, Qin WZ, Xu AE, Meng W
  Zhonghua Yu Fang Yi Xue Za Zhi. 2010
  PubMed ID: 20388336
   
  
• CTLA4 polymorphisms and COPD.
  Wood AM, Newby PR, Gough SC, Stockley RA
  Eur Respir J. 2010
  PubMed ID: 20123855
   
  
• CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.
  Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM
  Nat Immunol. 2010
  PubMed ID: 20037585
   
  
• Polymorphisms of cytotoxic T lymphocyte-associated antigen-4 and cytokine genes in Taiwanese patients with ankylosing spondylitis.
  Lee WY, Chang YH, Lo MK, Chang CP, Yang SC, Yang TP, Ho KT, Juan CW, Shiau MY
  Tissue Antigens. 2010
  PubMed ID: 20030788
   
  
• Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus.
  Jury EC, Flores-Borja F, Kalsi HS, Lazarus M, Isenberg DA, Mauri C, Ehrenstein MR
  Eur J Immunol. 2010
  PubMed ID: 19950182
   
  
• Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population.
  Xiao M, Qi F, Chen X, Luo Z, Zhang L, Zheng C, Hu S, Jiang X, Zhou M, Tang J
  Int J Immunogenet. 2010
  PubMed ID: 19922464
   
  
• Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population.
  Pawlak E, Karabon L, Wlodarska-Polinska I, Jedynak A, Jonkisz A, Tomkiewicz A, Kornafel J, Stepien M, Ignatowicz A, Lebioda A, Dobosz T, Frydecka I
  Hum Immunol. 2010
  PubMed ID: 19913589
   
  
• Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies.
  Brozzetti A, Marzotti S, Tortoioli C, Bini V, Giordano R, Dotta F, Betterle C, De Bellis A, Arnaldi G, Toscano V, Arvat E, Bellastella A, Mantero F, Falorni A, Italian Addison Network
  Eur J Endocrinol. 2010
  PubMed ID: 19884265
   
  
• Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.
  Järvinen TM, Hellquist A, Koskenmies S, Einarsdottir E, Koskinen LL, Jeskanen L, Berglind L, Panelius J, Hasan T, Ranki A, Kere J, Saarialho-Kere U
  Exp Dermatol. 2010
  PubMed ID: 19758313
   
  
• Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease.
  Gu LQ, Zhu W, Zhao SX, Zhao L, Zhang MJ, Cui B, Song HD, Ning G, Zhao YJ
  Clin Endocrinol (Oxf). 2010
  PubMed ID: 19438904
   
  
• Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.
  Jain N, Nguyen H, Chambers C, Kang J
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20080649
   
  
• CTLA4 gene variations and haplotypes in patients with lung cancer.
  Khaghanzadeh N, Erfani N, Ghayumi MA, Ghaderi A
  Cancer Genet Cytogenet. 2010
  PubMed ID: 20082854
   
  
• PD1 as a common candidate susceptibility gene of subacute sclerosing panencephalitis.
  Ishizaki Y, Yukaya N, Kusuhara K, Kira R, Torisu H, Ihara K, Sakai Y, Sanefuji M, Pipo-Deveza JR, Silao CL, Sanchez BC, Lukban MB, Salonga AM, Hara T
  Hum Genet. 2010
  PubMed ID: 20066438
   
  
• FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.
  Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T, Probst HC, van den Broek M
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20018763
   
  
• CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo.
  Haque A, Best SE, Amante FH, Mustafah S, Desbarrieres L, de Labastida F, Sparwasser T, Hill GR, Engwerda CR
  PLoS Pathog. 2010
  PubMed ID: 21170302
   
  
• CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice.
  Liu F, Liu J, Weng D, Chen Y, Song L, He Q, Chen J
  PLoS One. 2010
  PubMed ID: 21072213
   
  
• Evaluation of six CTLA-4 polymorphisms in high-risk melanoma patients receiving adjuvant interferon therapy in the He13A/98 multicenter trial.
  Gogas H, Dafni U, Koon H, Spyropoulou-Vlachou M, Metaxas Y, Buchbinder E, Pectasides E, Tsoutsos D, Polyzos A, Stratigos A, Markopoulos C, Panagiotou P, Fountzilas G, Castana O, Skarlos P, Atkins MB, Kirkwood JM
  J Transl Med. 2010
  PubMed ID: 21044351
   
  
• Association between the Cytotoxic T-lymphocyte antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis.
  Zheng J, Yu X, Jiang L, Xiao M, Bai B, Lu J, Zhou Y
  BMC Cancer. 2010
  PubMed ID: 20920330
   
  
• Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.
  Cross DS, Ivacic LC, Stefanski EL, McCarty CA
  BMC Genet. 2010
  PubMed ID: 20565774
   
  
• The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease.
  Hradsky O, Dusatkova P, Lenicek M, Bronsky J, Nevoral J, Vitek L, Lukas M, Zeniskova I, Cinek O
  BMC Med Genet. 2010
  PubMed ID: 20537165
   
  
• CTLA-4 A49G gene polymorphism is not associated with vitiligo in South Indian population.
  Deeba F, Syed R, Quareen J, Waheed MA, Jamil K, Rao H
  Indian J Dermatol. 2010
  PubMed ID: 20418973
   
  
• Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
  Ban HJ, Heo JY, Oh KS, Park KJ
  BMC Genet. 2010
  PubMed ID: 20416077
   
  
• Association of the CTLA4 gene with Graves' disease in the Chinese Han population.
  Zhao SX, Pan CM, Cao HM, Han B, Shi JY, Liang J, Gao GQ, Peng YD, Su Q, Chen JL, Zhao JJ, Song HD
  PLoS One. 2010
  PubMed ID: 20352109
   
  
• Cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms in Japanese children with infection-associated hemophagocytic lymphohistiocytosis.
  Yoshiyama M, Kounami S, Nakayama K, Okutani T, Aoyagi N, Yoshikawa N
  Acta Haematol. 2010
  PubMed ID: 20224272
   
  
• Association of plasma soluble CTLA-4 with lung function and gene polymorphism in Chinese asthmatic children.
  Chan IH, Tang NL, Leung TF, Lam YY, Wong GW, Wong CK, Lam CW
  Int Arch Allergy Immunol. 2010
  PubMed ID: 20016193
   
  
• CTLA-4 +49A>G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese.
  Qi P, Ruan CP, Wang H, Zhou FG, Xu XY, Gu X, Zhao YP, Dou TH, Gao CF
  Int J Colorectal Dis. 2010
  PubMed ID: 19787358
   
  
• Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease.
  Lopez-Escamez JA, Saenz-Lopez P, Acosta L, Moreno A, Gazquez I, Perez-Garrigues H, Lopez-Nevot A, Lopez-Nevot MA
  Laryngoscope. 2010
  PubMed ID: 19780033
   
  
• +49G > A polymorphism in the cytotoxic T-lymphocyte antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population.
  Gu X, Qi P, Zhou F, Ji Q, Wang H, Dou T, Zhao Y, Gao C
  Hum Immunol. 2010
  PubMed ID: 19778566
   
  
• Polymorphisms in genes involved in autoimmune disease and the risk of FVIII inhibitor development in Italian patients with haemophilia A.
  Bafunno V, Santacroce R, Chetta M, D'Andrea G, Pisanelli D, Sessa F, Trotta T, Tagariello G, Peyvandi F, Margaglione M
  Haemophilia. 2009
  PubMed ID: 20015215
   
  
• Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A.
  Pavlova A, Delev D, Lacroix-Desmazes S, Schwaab R, Mende M, Fimmers R, Astermark J, Oldenburg J
  J Thromb Haemost. 2009
  PubMed ID: 19817985
   
  
• CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.
  Kamesh L, Heward JM, Williams JM, Gough SC, Chavele KM, Salama A, Pusey C, Savage CO, Harper L
  Rheumatology (Oxford). 2009
  PubMed ID: 19815671
   
  
• The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage.
  Jin LP, Chen QY, Zhang T, Guo PF, Li DJ
  Clin Immunol. 2009
  PubMed ID: 19766059
   
  
• Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene.
  Kucharska AM, Gorska E, Wasik M, Pyrzak B, Demkow U
  J Physiol Pharmacol. 2009
  PubMed ID: 20134044
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Long-term follow-up of autoimmune pancreatitis: characteristics of chronic disease and recurrence.
  Kawa S, Hamano H, Ozaki Y, Ito T, Kodama R, Chou Y, Takayama M, Arakura N
  Clin Gastroenterol Hepatol. 2009
  PubMed ID: 19896092
   
  
• Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions.
  Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O, Sakaguchi S, Takikawa O, Miyasaka M
  J Immunol. 2009
  PubMed ID: 19843945
   
  
• Association and interaction analyses of eight genes under asthma linkage peaks.
  Ferreira MA, Zhao ZZ, Thomsen SF, James M, Evans DM, Postmus PE, Kyvik KO, Backer V, Boomsma DI, Martin NG, Montgomery GW, Duffy DL
  Allergy. 2009
  PubMed ID: 19824886
   
  
• PD-1 but not CTLA-4 blockage abrogates the protective effect of regulatory T cells in a pregnancy murine model.
  Wafula PO, Teles A, Schumacher A, Pohl K, Yagita H, Volk HD, Zenclussen AC
  Am J Reprod Immunol. 2009
  PubMed ID: 19811462
   
  
• Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms.
  Daroszewski J, Pawlak E, Karabon L, Frydecka I, Jonkisz A, Slowik M, Bolanowski M
  Eur J Endocrinol. 2009
  PubMed ID: 19734241
   
  
• Single nucleotide polymorphism of TAG-1 influences IVIg responsiveness of Japanese patients with CIDP.
  Iijima M, Tomita M, Morozumi S, Kawagashira Y, Nakamura T, Koike H, Katsuno M, Hattori N, Tanaka F, Yamamoto M, Sobue G
  Neurology. 2009
  PubMed ID: 19776380
   
  
• Genetic polymorphisms of immunoregulatory proteins in acute renal allograft rejection.
  Krichen H, Sfar I, Jendoubi-Ayed S, Makhlouf M, Ben Rhomdhane T, Bardi R, Aouadi H, Ben Abdallah T, Ayed K, Gorgi Y
  Transplant Proc. 2009
  PubMed ID: 19857736
   
  
• No association of CTLA-4 polymorphisms with susceptibility to Behçet disease.
  Du L, Yang P, Hou S, Zhou H, Kijlstra A
  Br J Ophthalmol. 2009
  PubMed ID: 19570770
   
  
• 49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease.
  Bicek A, Zaletel K, Gaberscek S, Pirnat E, Krhin B, Stopar TG, Hojker S
  Hum Immunol. 2009
  PubMed ID: 19559744
   
  
• Pretibial myxedema is associated with polymorphism in exon 1 of CTLA-4 gene in patients with Graves' ophthalmopathy.
  Khalilzadeh O, Mojazi Amiri H, Tahvildari M, Anvari M, Esteghamati A, Mobarra Z, Tehranchinia Z, Rashidi A, Amirzargar A
  Arch Dermatol Res. 2009
  PubMed ID: 19037649
   
  
• Cytotoxic T lymphocyte-associated antigen-4 polymorphism in patients with rheumatic heart disease.
  Düzgün N, Duman T, Haydardedeoğlu FE, Tutkak H
  Tissue Antigens. 2009
  PubMed ID: 19737369
   
  
• CTLA4 exon 1 and promoter polymorphisms in patients with multiple sclerosis.
  Yousefipour G, Erfani N, Momtahan M, Moghaddasi H, Ghaderi A
  Acta Neurol Scand. 2009
  PubMed ID: 19737153
   
  
• Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions.
  Kim SH, Lee JE, Kim SH, Jee YK, Kim YK, Park HS, Min KU, Park HW, The Adverse Drug Reaction Research Group in Korea
  Clin Exp Allergy. 2009
  PubMed ID: 19735272
   
  
• The CTLA-4 gene polymorphisms are associated with CTLA-4 protein expression levels in multiple sclerosis patients and with susceptibility to disease.
  Karabon L, Kosmaczewska A, Bilinska M, Pawlak E, Ciszak L, Jedynak A, Jonkisz A, Noga L, Pokryszko-Dragan A, Koszewicz M, Frydecka I
  Immunology. 2009
  PubMed ID: 19740340
   
  
• Association of polymorphism at position 49 in exon 1 of the cytotoxic T-lymphocyte-associated factor 4 gene with Graves' disease refractory to medical treatment, but not with amiodarone-associated thyroid dysfunction.
  Kimura H, Kato Y, Shimizu S, Takano K, Sato K
  Thyroid. 2009
  PubMed ID: 19731979
   
  
• A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury.
  Simone R, Brizzolara R, Chiappori A, Milintenda-Floriani F, Natale C, Greco L, Schiavo M, Bagnasco M, Pesce G, Saverino D
  Int Immunol. 2009
  PubMed ID: 19625381
   
  
• CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease.
  Park KS, Baek JA, Do JE, Bang D, Lee ES
  Tissue Antigens. 2009
  PubMed ID: 19563524
   
  
• Cytotoxic T-lymphocyte antigen 4 blockade augments the T-cell response primed by attenuated Listeria monocytogenes resulting in more rapid clearance of virulent bacterial challenge.
  Rowe JH, Johanns TM, Ertelt JM, Lai JC, Way SS
  Immunology. 2009
  PubMed ID: 19191906
   
  
• Association of Cytotoxic T Lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer.
  Hou R, Cao B, Chen Z, Li Y, Ning T, Li C, Xu C, Chen Z
  Mol Biol Rep. 2009
  PubMed ID: 19688278
   
  
• Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
  Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
  Eur Urol. 2009
  PubMed ID: 19692168
   
  
• Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
  Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP
  J Exp Med. 2009
  PubMed ID: 19581407
   
  
• [Association of cytotoxic T lymphocyte antigen-4 promoter C-658T polymorphism with ulcerative colitis in Chinese]
  Luo Y, Xia B, Li C, Chen ZT, Ge LQ, Jiang T
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009
  PubMed ID: 20017310
   
  
• Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune dysregulation.
  Sun T, Hu Z, Shen H, Lin D
  Cancer Res. 2009
  PubMed ID: 19638588
   
  
• CTLA4 variants, UV-induced tolerance, and risk of non-melanoma skin cancer.
  Welsh MM, Applebaum KM, Spencer SK, Perry AE, Karagas MR, Nelson HH
  Cancer Res. 2009
  PubMed ID: 19622768
   
  
• CTLA-4 gene polymorphism of exon 1(+49 A/G) in Turkish systemic lupus erythematosus patients.
  Ulker M, Yazisiz V, Sallakci N, Avci AB, Sanlioglu S, Yegin O, Terzioglu E
  Int J Immunogenet. 2009
  PubMed ID: 19602000
   
  
• Association between genotypes and phenotypes in coeliac disease.
  Gudjónsdóttir AH, Nilsson S, Naluai AT, Ek J, Amundsen SS, Wahlström J, Ascher H
  J Pediatr Gastroenterol Nutr. 2009
  PubMed ID: 19543113
   
  
• Phenotype-genotype interactions on renal function in type 2 diabetes: an analysis using structural equation modelling.
  Song XY, Lee SY, Ma RC, So WY, Cai JH, Tam C, Lam V, Ying W, Ng MC, Chan JC
  Diabetologia. 2009
  PubMed ID: 19479237
   
  
• Variation in the lymphotoxin-alpha/tumor necrosis factor locus modifies risk of erythema nodosum in sarcoidosis.
  McDougal KE, Fallin MD, Moller DR, Song Z, Cutler DJ, Steiner LL, Cutting GR, ACCESS Research Group
  J Invest Dermatol. 2009
  PubMed ID: 19225544
   
  
• PTEN identified as important risk factor of chronic obstructive pulmonary disease.
  Hosgood HD, Menashe I, He X, Chanock S, Lan Q
  Respir Med. 2009
  PubMed ID: 19625176
   
  
• Human type 1 and 17 responses in latent tuberculosis are modulated by coincident filarial infection through cytotoxic T lymphocyte antigen-4 and programmed death-1.
  Babu S, Bhat SQ, Kumar NP, Jayantasri S, Rukmani S, Kumaran P, Gopi PG, Kolappan C, Kumaraswami V, Nutman TB
  J Infect Dis. 2009
  PubMed ID: 19505258
   
  
• A candidate gene association study of 77 polymorphisms in migraine.
  Schürks M, Kurth T, Buring JE, Zee RY
  J Pain. 2009
  PubMed ID: 19559392
   
  
• Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients.
  Esteghamati A, Khalilzadeh O, Mobarra Z, Anvari M, Tahvildari M, Amiri HM, Rashidi A, Solgi G, Parivar K, Nikbin B, Amirzargar A
  Eur J Intern Med. 2009
  PubMed ID: 19524188
   
  
• REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
  Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL, Xie G, Begovich AB, Siminovitch KA
  Nat Genet. 2009
  PubMed ID: 19503088
   
  
• Influence of CTLA-4 gene polymorphism in autoimmune and infectious diseases.
  Fernández-Mestre M, Sánchez K, Balbás O, Gendzekhzadze K, Ogando V, Cabrera M, Layrisse Z
  Hum Immunol. 2009
  PubMed ID: 19345707
   
  
• Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
  Rogers AJ, Raby BA, Lasky-Su JA, Murphy A, Lazarus R, Klanderman BJ, Sylvia JS, Ziniti JP, Lange C, Celedón JC, Silverman EK, Weiss ST
  Am J Respir Crit Care Med. 2009
  PubMed ID: 19264973
   
  
• Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal.
  Hara S, Nakaseko C, Yamasaki S, Hattori M, Bos JL, Saito Y, Minato N, Saito T
  Hematology. 2009
  PubMed ID: 19490760
   
  
• CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation.
  Sojka DK, Hughson A, Fowell DJ
  Eur J Immunol. 2009
  PubMed ID: 19462377
   
  
• Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak.
  Chen RF, Wang L, Cheng JT, Chuang H, Chang JC, Liu JW, Lin IC, Yang KD
  Clin Immunol. 2009
  PubMed ID: 19269255
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Lentiviral gene transfer of CTLA4 generates B cells with reduced costimulatory properties.
  Vogt B, Warncke M, Micheel B, Sheriff A
  Autoimmunity. 2009
  PubMed ID: 19811307
   
  
• [Polymorphisms in inflammatory response genes in metastatic renal cancer]
  Sáenz López P, Vázquez Alonso F, Romero JM, Carretero R, Tallada Buñuel M, Ruiz Cabello F, Cózar Olmo JM
  Actas Urol Esp. 2009
  PubMed ID: 19658300
   
  
• The clinical utility of inhibiting CD28-mediated costimulation.
  Linsley PS, Nadler SG
  Immunol Rev. 2009
  PubMed ID: 19426230
   
  
• Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis.
  Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TW, Toes RE
  Arthritis Rheum. 2009
  PubMed ID: 19404967
   
  
• Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells.
  Hoff H, Knieke K, Cabail Z, Hirseland H, Vratsanos G, Burmester GR, Jorch G, Nadler SG, Bröker B, Hebel K, Brunner-Weinzierl MC
  J Immunol. 2009
  PubMed ID: 19380781
   
  
• Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation.
  Wu J, Tang JL, Wu SJ, Lio HY, Yang YC
  Clin Chim Acta. 2009
  PubMed ID: 19332044
   
  
• Analyses of associations with asthma in four asthma population samples from Canada and Australia.
  Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Paré PD, Hudson TJ
  Hum Genet. 2009
  PubMed ID: 19247692
   
  
• Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
  Environ Mol Mutagen. 2009
  PubMed ID: 19170196
   
  
• Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells.
  Liu Y, Yu Y, Yang S, Zeng B, Zhang Z, Jiao G, Zhang Y, Cai L, Yang R
  Cancer Immunol Immunother. 2009
  PubMed ID: 18828017
   
  
• CTLA4 gene polymorphisms are associated with chronic bronchitis.
  Zhu G, Agusti A, Gulsvik A, Bakke P, ICGN investigators, Coxson H, Lomas DA, Silverman EK, Pillai SG
  Eur Respir J. 2009
  PubMed ID: 19386687
   
  
• Synergistic inhibition of T-cell activation by a cell-permeable ZAP-70 mutant and ctCTLA-4.
  Kim KD, Choi JM, Chae WJ, Lee SK
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19230824
   
  
• CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
  Kurtz J, Raval F, Vallot C, Der J, Sykes M
  Blood. 2009
  PubMed ID: 19179471
   
  
• CTLA4 silencing with siRNA promotes deviation of Th1/Th2 in chronic hepatitis B patients.
  Yu Y, Wu H, Tang Z, Zang G
  Cell Mol Immunol. 2009
  PubMed ID: 19403062
   
  
• CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.
  Walker EJ, Hirschfield GM, Xu C, Lu Y, Liu X, Lu Y, Coltescu C, Wang K, Newman WG, Bykerk V, Keystone EC, Mosher D, Amos CI, Heathcote EJ, Siminovitch KA
  Arthritis Rheum. 2009
  PubMed ID: 19333938
   
  
• The association of CTLA-4 and CD28 gene polymorphisms with idiopathic ischemic stroke in the paediatric population.
  Wang JJ, Jiang LQ, He B, Shi KL, Li JW, Zou LP
  Int J Immunogenet. 2009
  PubMed ID: 19284445
   
  
• Cytotoxic T lymphocyte-associated molecule-4 polymorphism in Turkish patients with Hashimoto thyroiditis.
  Sahin M, Gursoy A, Erdogan MF
  Int J Immunogenet. 2009
  PubMed ID: 19284444
   
  
• Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
  Zee RY, Bubes V, Shrivastava S, Ridker PM, Glynn RJ
  Clin Chim Acta. 2009
  PubMed ID: 19263529
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
  Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
  Pediatr Infect Dis J. 2009
  PubMed ID: 19258923
   
  
• Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.
  Verhagen J, Gabrysová L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, Wraith DC
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19218450
   
  
• CTLA-4 +49A/G polymorphism is associated with Behçet's disease in a Tunisian population.
  Ben Dhifallah I, Chelbi H, Braham A, Hamzaoui K, Houman MH
  Tissue Antigens. 2009
  PubMed ID: 19254250
   
  
• CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin.
  Hegel JK, Knieke K, Kolar P, Reiner SL, Brunner-Weinzierl MC
  Eur J Immunol. 2009
  PubMed ID: 19224637
   
  
• A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
  Wang X, Cheng S, Brophy VH, Erlich HA, Mannhalter C, Berger K, Lalouschek W, Browner WS, Shi Y, Ringelstein EB, Kessler C, Luedemann J, Lindpaintner K, Liu L, Ridker PM, Zee RY, Cook NR, RMS Stroke SNP Consortium
  Stroke. 2009
  PubMed ID: 19131662
   
  
• Association between IL4 (-590), ACE (I)/(D), CCR5 (Delta32), CTLA4 (+49) and IL1-RN (VNTR in intron 2) gene polymorphisms and vitiligo.
  Pehlivan S, Ozkinay F, Alper S, Onay H, Yuksel E, Pehlivan M, Ozkinay C
  Eur J Dermatol. 2009
  PubMed ID: 19129082
   
  
• CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy.
  Pérez-García A, Brunet S, Berlanga JJ, Tormo M, Nomdedeu J, Guardia R, Ribera JM, Heras I, Llorente A, Hoyos M, Esteve J, Besalduch J, Bueno J, Sierra J, Gallardo D, Grupo cooperativo para el estudio y tratamiento de las leucemias agudas
  Leukemia. 2009
  PubMed ID: 19092854
   
  
• The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.
  Haimila K, Einarsdottir E, de Kauwe A, Koskinen LL, Pan-Hammarström Q, Kaartinen T, Kurppa K, Ziberna F, Not T, Vatta S, Ventura A, Korponay-Szabo IR, Adány R, Pocsai Z, Széles G, Dukes E, Kaukinen K, Mäki M, Koskinen S, Partanen J, Hammarström L, Saavalainen P
  Genes Immun. 2009
  PubMed ID: 19020530
   
  
• The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats.
  Huang LF, Yao YM, Zhang LT, Dong N, Yu Y, Sheng ZY
  Shock. 2009
  PubMed ID: 18665051
   
  
• CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.
  Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA
  J Exp Med. 2009
  PubMed ID: 19188497
   
  
• Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation.
  Haimila K, Turpeinen H, Alakulppi NS, Kyllönen LE, Salmela KT, Partanen J
  Transplantation. 2009
  PubMed ID: 19202444
   
  
• A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis.
  Benson M, Mobini R, Barrenäs F, Halldén C, Naluai AT, Säll T, Cardell LO
  Allergy. 2009
  PubMed ID: 19222422
   
  
• Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
  Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
  Am J Obstet Gynecol. 2009
  PubMed ID: 19019335
   
  
• Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGF beta gene variants.
  Barreto M, Ferreira RC, Lourenco L, Moraes-Fontes MF, Santos E, Alves M, Carvalho C, Martins B, Andreia R, Viana JF, Vasconcelos C, Mota-Vieira L, Ferreira C, Demengeot J, Vicente AM
  BMC Immunol. 2009
  PubMed ID: 19173720
   
  
• CTLA4 and Generalized Vitiligo: Two Genetic Association Studies and a Meta-Analysis of Published Data.
  Birlea SA, Laberge GS, Procopciuc LM, Fain PR, Spritz RA
  Pigment Cell Melanoma Res. 2009
  PubMed ID: 19175525
   
  
• [Susceptibility genetic variants in Hungarian morbus Crohn and ulcerative colitis patients]
  Magyari L, Melegh B
  Orv Hetil. 2009
  PubMed ID: 19103559
   
  
• TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells.
  Elrefaei M, Burke CM, Baker CA, Jones NG, Bousheri S, Bangsberg DR, Cao H
  PLoS One. 2009
  PubMed ID: 20016783
   
  
• [Genetic predisposition to multiple sclerosis as a polygenic autoimmune disease]
  Favorova OO, Favorov AV, Boĭko AN, Sudomoina MA, Andreevskiĭ TV, Alekseenkov AD, Kulakova OG, Gusev EI, Parmigiani G, Ochs MF
  Zh Nevrol Psikhiatr Im S S Korsakova. 2009
  PubMed ID: 19894308
   
  
• CTLA4 autoimmunity-associated genotype contributes to severe pulmonary tuberculosis in an African population.
  Thye T, Scarisbrick G, Browne EN, Chinbuah MA, Gyapong J, Osei I, Owusu-Dabo E, Niemann S, Rüsch-Gerdes S, Meyer CG, Horstmann RD
  PLoS One. 2009
  PubMed ID: 19609446
   
  
• Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity.
  Toussirot E, Saas P, Deschamps M, Pouthier F, Perrot L, Perruche S, Chabod J, Tiberghien P, Wendling D
  Arthritis Res Ther. 2009
  PubMed ID: 19570209
   
  
• If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
  Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
  Reprod Biol Endocrinol. 2009
  PubMed ID: 19527514
   
  
• CD152 (CTLA-4) determines CD4 T cell migration in vitro and in vivo.
  Knieke K, Hoff H, Maszyna F, Kolar P, Schrage A, Hamann A, Debes GF, Brunner-Weinzierl MC
  PLoS One. 2009
  PubMed ID: 19479036
   
  
• PDCD1, CTLA-4 and p53 gene polymorphism and susceptibility to gestational trophoblastic diseases.
  Dehaghani AS, Kashef MA, Ghaemenia M, Sarraf Z, Khaghanzadeh N, Fattahi MJ, Ghaderi A
  J Reprod Med. 2009
  PubMed ID: 19263877
   
  
• Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort.
  Martin TM, Bye L, Modi N, Stanford MR, Vaughan R, Smith JR, Wade NK, Mackensen F, Suhler EB, Rosenbaum JT, Wallace GR
  Mol Vis. 2009
  PubMed ID: 19180256
   
  
• CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice.
  Kolar P, Knieke K, Hegel JK, Quandt D, Burmester GR, Hoff H, Brunner-Weinzierl MC
  Arthritis Rheum. 2009
  PubMed ID: 19116935
   
  
• Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay.
  Greisenegger S, Zehetmayer S, Bauer P, Endler G, Ferrari J, Lang W, Janisiw M, Steiner L, Cheng S, Lalouschek W, Mannhalter C
  Clin Chem. 2009
  PubMed ID: 19028820
   
  
• Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
  Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A
  J Infect Dis. 2009
  PubMed ID: 19012493
   
  
• CTLA4 targeting strategy in DNA vaccination against periodontitis.
  Yu F, Xu QA, Sun G, Chen W
  Med Hypotheses. 2009
  PubMed ID: 18783892
   
  
• Cytotoxic T lymphocyte antigen-4 promoter -658CT gene polymorphism is associated with ulcerative colitis in Chinese patients.
  Luo Y, Xia B, Li C, Chen Z, Ge L, Jiang T, Zhou F, Zhao Y
  Int J Colorectal Dis. 2008
  PubMed ID: 19089435
   
  
• Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis.
  Choi JM, Kim SH, Shin JH, Gibson T, Yoon BS, Lee DH, Lee SK, Bothwell AL, Lim JS, Lee SK
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 19066215
   
  
• Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis.
  Flores-Borja F, Jury EC, Mauri C, Ehrenstein MR
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 19036923
   
  
• Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
  Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA
  Nat Genet. 2008
  PubMed ID: 18978792
   
  
• Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis.
  Watanabe K, Rao VP, Poutahidis T, Rickman BH, Ohtani M, Xu S, Rogers AB, Ge Z, Horwitz BH, Fujioka T, Erdman SE, Fox JG
  Infect Immun. 2008
  PubMed ID: 18824539
   
  
• CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors.
  Shah KV, Chien AJ, Yee C, Moon RT
  J Invest Dermatol. 2008
  PubMed ID: 18563180
   
  
• Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells.
  Jarvis LB, Goodall JC, Gaston JS
  Hum Immunol. 2008
  PubMed ID: 18817831
   
  
• Effects of inhaled fluticasone propionate on CTLA-4-positive CD4+CD25+ cells in induced sputum in mild asthmatics.
  Kawayama T, Kinoshita T, Imaoka H, Gauvreau GM, O'Byrne PM, Aizawa H
  Respirology. 2008
  PubMed ID: 18699801
   
  
• Influence of the TSH Receptor Gene on Susceptibility to Graves' Disease and Graves' Ophthalmopathy.
  Yin X, Latif R, Bahn R, Tomer Y, Davies TF
  Thyroid. 2008
  PubMed ID: 18925838
   
  
• A common CTLA4 polymorphism confers susceptibility to Autoimmune Thyroid Disease in celiac children.
  Tolone C, Cirillo G, Papparella A, Tolone S, Santoro N, Grandone A, Perrone L, Del Giudice EM
  Dig Liver Dis. 2008
  PubMed ID: 18929517
   
  
• CTLA-4 control over Foxp3+ regulatory T cell function.
  Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S
  Science. 2008
  PubMed ID: 18845758
   
  
• [Expressions of Fas, CTLA-4 and RhoBTB2 genes in breast carcinoma and their relationship with clinicopathological factors]
  Bi Y, Wei L, Mao HT, Zhang L, Zuo WS
  Zhonghua Zhong Liu Za Zhi. 2008
  PubMed ID: 19173804
   
  
• Genetic factors of susceptibility and of severity in primary biliary cirrhosis.
  Poupon R, Ping C, Chrétien Y, Corpechot C, Chazouillères O, Simon T, Heath SC, Matsuda F, Poupon RE, Housset C, Barbu V
  J Hepatol. 2008
  PubMed ID: 18930330
   
  
• Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
  Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
  Carcinogenesis. 2008
  PubMed ID: 18676680
   
  
• Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
  Habermann TM, Wang SS, Maurer MJ, Morton LM, Lynch CF, Ansell SM, Hartge P, Severson RK, Rothman N, Davis S, Geyer SM, Cozen W, Chanock SJ, Cerhan JR
  Blood. 2008
  PubMed ID: 18633131
   
  
• CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia.
  Jones AL, Holliday EG, Mowry BJ, McLean DE, McGrath JJ, Pender MP, Greer JM
  Brain Behav Immun. 2008
  PubMed ID: 18848621
   
  
• Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer.
  Sun T, Zhou Y, Yang M, Hu Z, Tan W, Han X, Shi Y, Yao J, Guo Y, Yu D, Tian T, Zhou X, Shen H, Lin D
  Cancer Res. 2008
  PubMed ID: 18757416
   
  
• CTLA4 gene polymorphisms in children and adolescents with autoimmune thyroid diseases.
  Yeşilkaya E, Koç A, Bideci A, Camurdan O, Boyraz M, Erkal O, Ergun MA, Cinaz P
  Genet Test. 2008
  PubMed ID: 18752454
   
  
• Anergy in memory CD4+ T cells is induced by B cells.
  Dalai SK, Mirshahidi S, Morrot A, Zavala F, Sadegh-Nasseri S
  J Immunol. 2008
  PubMed ID: 18713993
   
  
• CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS.
  Hodi FS, Oble DA, Drappatz J, Velazquez EF, Ramaiya N, Ramakrishna N, Day AL, Kruse A, Mac Rae S, Hoos A, Mihm M
  Nat Clin Pract Oncol. 2008
  PubMed ID: 18665147
   
  
• Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis.
  Gu M, Kakoulidou M, Giscombe R, Pirskanen R, Lefvert AK, Klareskog L, Wang X
  Clin Immunol. 2008
  PubMed ID: 18595775
   
  
• TcR-induced regulated secretion leads to surface expression of CTLA-4 in CD4+CD25+ T cells.
  Catalfamo M, Tai X, Karpova T, McNally J, Henkart PA
  Immunology. 2008
  PubMed ID: 18397268
   
  
• CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
  Kavanagh B, O'Brien S, Lee D, Hou Y, Weinberg V, Rini B, Allison JP, Small EJ, Fong L
  Blood. 2008
  PubMed ID: 18523152
   
  
• Genomic regulation of CTLA4 and Multiple Sclerosis.
  Palacios R, Comas D, Elorza J, Villoslada P
  J Neuroimmunol. 2008
  PubMed ID: 18691768
   
  
• Cytotoxic T lymphocyte associated antigen-4 exon 1 A/G polymorphism in Iranian patients with multiple sclerosis.
  Borhani Haghighi A, Ghahramani S, Azarpira N, Pourjafar M, Nikseresht AR
  Eur J Neurol. 2008
  PubMed ID: 18705023
   
  
• Study of gene-gene interactions for endophenotypic quantitative traits in Chinese asthmatic children.
  Chan IH, Tang NL, Leung TF, Huang W, Lam YY, Li CY, Wong CK, Wong GW, Lam CW
  Allergy. 2008
  PubMed ID: 18691306
   
  
• [Association of polymorphism of proteintyrosine phosphatase nonreceptor-22 gene with AITD.]
  Yu ZY, Zhang JA, Maier HB, Wang Y, Xiao WX, Quan Y, Dong BN
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008
  PubMed ID: 18687223
   
  
• Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer.
  Dilmec F, Ozgonul A, Uzunkoy A, Akkafa F
  Int J Immunogenet. 2008
  PubMed ID: 18680513
   
  
• CTLA4 expression is an indicator and regulator of steady-state CD4+ FoxP3+ T cell homeostasis.
  Tang AL, Teijaro JR, Njau MN, Chandran SS, Azimzadeh A, Nadler SG, Rothstein DM, Farber DL
  J Immunol. 2008
  PubMed ID: 18641318
   
  
• Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
  Zheng Y, Manzotti CN, Burke F, Dussably L, Qureshi O, Walker LS, Sansom DM
  J Immunol. 2008
  PubMed ID: 18641304
   
  
• Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis.
  Oble DA, Mino-Kenudson M, Goldsmith J, Hodi FS, Seliem RM, Dranoff G, Mihm M, Hasserjian R, Lauwers GY
  Am J Surg Pathol. 2008
  PubMed ID: 18545145
   
  
• Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation.
  Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18635688
   
  
• Analysis of single nucleotide polymorphisms in the FAS and CTLA-4 genes of peripheral T-cell lymphomas.
  Bonzheim I, Geissinger E, Chuang WY, Roth S, Ströbel P, Marx A, Reimer P, Wilhelm M, Puppe B, Rosenwald A, Müller-Hermelink HK, Rüdiger T
  J Hematop. 2008
  PubMed ID: 19669200
   
  
• CTLA-4 gene variants are not associated with Behçet's disease or its clinical manifestations.
  Touma Z, Hamdan A, Shamseddeen W, Nasr J, Makhoul N, Zalloua PA, Arayssi T
  Clin Exp Rheumatol. 2008
  PubMed ID: 19026137
   
  
• Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children.
  Tsai ST, Huang CY, Lo FS, Chang YT, Tanizawa T, Chen CK, Wang ZC, Liu HF, Chu CC, Lin M, Lin CH, Li HJ, Lee YJ
  J Pediatr Endocrinol Metab. 2008
  PubMed ID: 18780601
   
  
• Primary Biliary Cirrhosis Is Associated With a Genetic Variant in the 3' Flanking Region of the CTLA4 Gene.
  Juran BD, Atkinson EJ, Schlicht EM, Fridley BL, Lazaridis KN
  Gastroenterology. 2008
  PubMed ID: 18778710
   
  
• [Effects of Tongbi Mixture 2 on expressions of CD28 and CD152 and content of tumor necrosis factor-alpha in peripheral blood in rats with collagen-induced arthritis]
  Liu H, Liu QP, Chen JF, Huang YM, Xu Q, Li SG
  Zhong Xi Yi Jie He Xue Bao. 2008
  PubMed ID: 18601859
   
  
• Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis.
  Prahalad S, Bohnsack JF, Whiting A, Clifford B, Jorde LB, Guthery SL, Thompson SD, Glass DN, Bamshad MJ
  Arthritis Rheum. 2008
  PubMed ID: 18576317
   
  
• Global T cell dysregulation in non-autoimmune-prone mice promotes rapid development of BAFF-independent, systemic lupus erythematosus-like autoimmunity.
  Stohl W, Jacob N, Quinn WJ, Cancro MP, Gao H, Putterman C, Gao X, Pricop L, Koss MN
  J Immunol. 2008
  PubMed ID: 18566449
   
  
• Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade.
  Breunis WB, Tarazona-Santos E, Chen R, Kiley M, Rosenberg SA, Chanock SJ
  J Immunother. 2008
  PubMed ID: 18528295
   
  
• Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells.
  George JF, Braun A, Brusko TM, Joseph R, Bolisetty S, Wasserfall CH, Atkinson MA, Agarwal A, Kapturczak MH
  Am J Pathol. 2008
  PubMed ID: 18511516
   
  
• Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese.
  Umemura T, Ota M, Yoshizawa K, Katsuyama Y, Ichijo T, Tanaka E, Kiyosawa K
  Hepatol Res. 2008
  PubMed ID: 18371160
   
  
• New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer.
  Guzman VB, Yambartsev A, Goncalves-Primo A, Silva ID, Carvalho CR, Ribalta JC, Goulart LR, Shulzhenko N, Gerbase-Delima M, Morgun A
  Hum Mol Genet. 2008
  PubMed ID: 18337305
   
  
• Immunological inhibition of transplanted liver allografts by adeno-associated virus vector encoding CTLA4Ig in rats.
  Lu S, Yu Y, Gao Y, Li GQ, Wang XH
  Hepatobiliary Pancreat Dis Int. 2008
  PubMed ID: 18522879
   
  
• CTLA-4 trafficking and surface expression.
  Valk E, Rudd CE, Schneider H
  Trends Immunol. 2008
  PubMed ID: 18468488
   
  
• Association of CTLA-4 and IL-13 Gene Polymorphisms with Graves' Disease and Ophthalmopathy in Chinese Children.
  Chong KK, Chiang SW, Wong GW, Tam PO, Ng TK, Hu YJ, Yam GH, Lam DS, Pang CP
  Invest Ophthalmol Vis Sci. 2008
  PubMed ID: 18296657
   
  
• CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients.
  Botturi K, Lacoeuille Y, Thomas P, Boniface S, Reynaud-Gaubert M, Magnan A
  Eur Respir J. 2008
  PubMed ID: 18256061
   
  
• CTLA-4 polymorphisms are not associated with ocular inflammatory disease.
  Bye L, Modi N, Stanford MR, Kondeatis E, Vaughan R, Fortune F, Kanawati C, Ben-Chetrit E, Ghabra M, Murray PI, Wallace GR
  Tissue Antigens. 2008
  PubMed ID: 18498289
   
  
• Graves' Disease in Brazilian Children and Adults: Lack of Genetic Association with CTLA-4 +49A>G Polymorphism.
  Namo Cury A, Longui CA, Kochi C, Calliari LE, Scalissi N, Salles JE, Neves Rocha M, Barbosa de Melo M, Rezende Melo M, Monte O
  Horm Res. 2008
  PubMed ID: 18493148
   
  
• Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
  Costenbader KH, Chang SC, De Vivo I, Plenge R, Karlson EW
  Arthritis Res Ther. 2008
  PubMed ID: 18462498
   
  
• CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schönlein purpura.
  Soylemezoglu O, Peru H, Gonen S, Cetinyurek A, Ozkaya O, Bakkaloğlu S, Buyan N, Hasanoglu E
  Pediatr Nephrol. 2008
  PubMed ID: 18449568
   
  
• CTLA-4 and multiple sclerosis: The A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population.
  Wray BN, Stankovich J, Whittock L, Dwyer T, Ponsonby AL, van der Mei IA, Taylor B, Dickinson J, Foote S, McMorran BJ
  J Neuroimmunol. 2008
  PubMed ID: 18378005
   
  
• Immunoregulatory gene polymorphisms are associated with ANCA-related vasculitis.
  Slot MC, Sokolowska MG, Savelkouls KG, Janssen RG, Damoiseaux JG, Cohen Tervaert JW
  Clin Immunol. 2008
  PubMed ID: 18448390
   
  
• Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.
  Du L, Yang P, Hou S, Lin X, Zhou H, Huang X, Wang L, Kijlstra A
  Clin Immunol. 2008
  PubMed ID: 18282809
   
  
• Regulation of CD28 expression on CD8+ T cells by CTLA-4.
  Berg M, Zavazava N
  J Leukoc Biol. 2008
  PubMed ID: 18162511
   
  
• Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population.
  Suwalska K, Pawlak E, Karabon L, Tomkiewicz A, Dobosz T, Urbaniak-Kujda D, Kuliczkowski K, Wolowiec D, Jedynak A, Frydecka I
  Hum Immunol. 2008
  PubMed ID: 18396212
   
  
• Association of autoimmune pancreatitis with cytotoxic T-lymphocyte antigen 4 gene polymorphisms in Japanese patients.
  Umemura T, Ota M, Hamano H, Katsuyama Y, Muraki T, Arakura N, Kawa S, Kiyosawa K
  Am J Gastroenterol. 2008
  PubMed ID: 18341485
   
  
• [Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms with susceptibility to breast cancer.]
  Li H, Fu ZK, Wang LH, Li DL, Wu N, Zhang J, Li DJ
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008
  PubMed ID: 18328194
   
  
• CTLA-4 CT60 polymorphism is not an independent genetic risk marker of rheumatoid arthritis in a Japanese population.
  Tsukahara S, Iwamoto T, Ikari K, Inoue E, Tomatsu T, Hara M, Yamanaka H, Kamatani N, Momohara S
  Ann Rheum Dis. 2008
  PubMed ID: 18292106
   
  
• Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis: effect of age, gender, and genetic background.
  Bittencourt PL, Farias AQ, Porta G, Cançado EL, Miura I, Pugliese R, Kalil J, Goldberg AC, Carrilho FJ
  J Clin Gastroenterol. 2008
  PubMed ID: 18223493
   
  
• Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls.
  Pavlova A, Diaz-Lacava A, Zeitler H, Satoguina J, Niemann B, Krause M, Scharrer I, Hoerauf A, Wienker T, Oldenburg J
  Haemophilia. 2008
  PubMed ID: 18081831
   
  
• Family-based association study of cytotoxic T-lymphocyte antigen-4 with susceptibility to Graves' disease in Han population of Taiwan.
  Chen PL, Fann CS, Chang CC, Wu IL, Chiu WY, Lin CY, Yang WS, Chang TC
  Genes Immun. 2008
  PubMed ID: 18059468
   
  
• Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2.
  Zhang X, Zhang C, Tang T, Qu Z, Lou J, Dai K
  J Orthop Res. 2008
  PubMed ID: 17960657
   
  
• Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60: no association in patients from Germany, Hungary and Poland.
  Greve B, Simonenko R, Illes Z, Peterfalvi A, Hamdi N, Mycko MP, Selmaj KW, Rozsa C, Rajczy K, Bauer P, Berger K, Weissert R
  Mult Scler. 2008
  PubMed ID: 17942509
   
  
• Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease.
  Kisiel B, Bednarczuk T, Kostrzewa G, Kosińska J, Miśkiewicz P, Płazińska MT, Bar-Andziak E, Królicki L, Krajewski P, Płoski R
  Clin Endocrinol (Oxf). 2008
  PubMed ID: 17941906
   
  
• Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study.
  Karlson EW, Chibnik LB, Cui J, Plenge RM, Glass RJ, Maher NE, Parker A, Roubenoff R, Izmailova E, Coblyn JS, Weinblatt ME, Shadick NA
  Ann Rheum Dis. 2008
  PubMed ID: 17666451
   
  
• Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis.
  Garrido P, Almeida J, Romero JM, Cantón J, Sandberg Y, Bárcena P, Lima M, Langerak AW, Orfao A, Ruiz-Cabello F
  Hum Immunol. 2008
  PubMed ID: 18361934
   
  
• Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
  Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
  Rheumatology (Oxford). 2008
  PubMed ID: 18174230
   
  
• IL-27 inhibits the development of regulatory T cells via STAT3.
  Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M
  Int Immunol. 2008
  PubMed ID: 18156621
   
  
• Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population.
  Łuszczek W, Majorczyk E, Nockowski P, Pluciński P, Jasek M, Nowak I, Wiśniewski A, Kuśnierczyk P
  Int J Immunogenet. 2008
  PubMed ID: 18093182
   
  
• Interacting alleles of the coinhibitory immunoreceptor genes cytotoxic T-lymphocyte antigen 4 and programmed cell-death 1 influence risk and features of primary biliary cirrhosis.
  Juran BD, Atkinson EJ, Schlicht EM, Fridley BL, Petersen GM, Lazaridis KN
  Hepatology. 2008
  PubMed ID: 18041714
   
  
• PTPN22 Is Genetically Associated with Risk of Generalized Vitiligo, but CTLA4 Is Not.
  Laberge GS, Bennett DC, Fain PR, Spritz RA
  J Invest Dermatol. 2008
  PubMed ID: 18200060
   
  
• Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms.
  Berry A, Tector M, Oaks MK
  J Negat Results Biomed. 2008
  PubMed ID: 19014504
   
  
• Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis.
  Atik B, Skwor TA, Kandel RP, Sharma B, Adhikari HK, Steiner L, Erlich H, Dean D
  PLoS ONE. 2008
  PubMed ID: 18974840
   
  
• Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
  Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
  PLoS ONE. 2008
  PubMed ID: 18818748
   
  
• Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
  Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
  PLoS ONE. 2008
  PubMed ID: 18636124
   
  
• CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization.
  Schneider H, Smith X, Liu H, Bismuth G, Rudd CE
  Eur J Immunol. 2008
  PubMed ID: 18095376
   
  
• Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis.
  Wang XB, Pirskanen R, Giscombe R, Lefvert AK
  J Intern Med. 2008
  PubMed ID: 18088253
   
  
• The 3' UTR of the human CTLA4 mRNA can regulate mRNA stability and translational efficiency.
  Malquori L, Carsetti L, Ruberti G
  Biochim Biophys Acta. 2008
  PubMed ID: 18078835
   
  
• CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women.
  Jääskeläinen E, Toivonen S, Keski-Nisula L, Paattiniemi EL, Helisalmi S, Punnonen K, Heinonen S
  Clin Chem Lab Med. 2008
  PubMed ID: 18076363
   
  
• CT60 A/G marker of the 3'-UTR of the CTLA4 gene and liver transplant.
  Muro M, Rojas G, Botella C, Miras M, Campillo JA, Minguela A, Sánchez-Bueno F, Bermejo J, Ramírez P, Alvarez-López MR
  Transpl Immunol. 2008
  PubMed ID: 18047932
   
  
• Adult T-cell leukemia/lymphoma cells from blood and skin tumors express cytotoxic T lymphocyte-associated antigen-4 and Foxp3 but lack suppressor activity toward autologous CD8+ T cells.
  Shimauchi T, Kabashima K, Tokura Y
  Cancer Sci. 2008
  PubMed ID: 17970785
   
  
• Donor CTLA-4 +49 A/G*GG genotype is associated with chronic GVHD after HLA-identical haematopoietic stem-cell transplantations.
  Azarian M, Busson M, Lepage V, Charron D, Toubert A, Loiseau P, de Latour RP, Rocha V, Socié G
  Blood. 2007
  PubMed ID: 18056853
   
  
• CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers.
  Hadinia A, Hossieni SV, Erfani N, Saberi-Firozi M, Fattahi MJ, Ghaderi A
  J Gastroenterol Hepatol. 2007
  PubMed ID: 18031393
   
  
• A new role of CTLA-4 on B cells in thymus-dependent immune responses in vivo.
  Quandt D, Hoff H, Rudolph M, Fillatreau S, Brunner-Weinzierl MC
  J Immunol. 2007
  PubMed ID: 18025174
   
  
• Susceptible alleles of the CD40 and CTLA-4 genes are not associated with the relapse after antithyroid withdrawal in Graves' disease.
  Kim KW, Park YJ, Kim TY, Park do J, Park KS, Cho BY
  Thyroid. 2007
  PubMed ID: 17949264
   
  
• Allelic variant in CTLA4 alters T cell phosphorylation patterns.
  Maier LM, Anderson DE, De Jager PL, Wicker LS, Hafler DA
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 18000051
   
  
• Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease.
  Schott E, Witt H, Pascu M, van Boemmel F, Weich V, Bergk A, Halangk J, Müller T, Puhl G, Wiedenmann B, Berg T
  Eur J Gastroenterol Hepatol. 2007
  PubMed ID: 18049163
   
  
• Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients.
  Kusztal M, Radwan-Oczko M, Kościelska-Kasprzak K, Boratyńska M, Patrzałek D, Klinger M
  Transplant Proc. 2007
  PubMed ID: 18021981
   
  
• Genotype frequency and F ST analysis of polymorphisms in immunoregulatory genes in Chinese and Caucasian populations.
  Lan Q, Shen M, Garcia-Rossi D, Chanock S, Zheng T, Berndt SI, Puri V, Li G, He X, Welch R, Zahm SH, Zhang L, Zhang Y, Smith M, Wang SS, Chiu BC, Linet M, Hayes R, Rothman N, Yeager M
  Immunogenetics. 2007
  PubMed ID: 17938902
   
  
• Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis.
  Stuart R, Lovett-Racke AE, Frohman EM, Hawker K, Racke MK
  J Neuroimmunol. 2007
  PubMed ID: 17920697
   
  
• Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients.
  Jiang Z, Feng X, Zhang W, Gao F, Ling Q, Zhou L, Xie H, Chen Q, Zheng S
  Liver Int. 2007
  PubMed ID: 17919231
   
  
• Significance of CTLA-4 and CD14 genetic polymorphisms in clinical outcome after allogeneic stem cell transplantation.
  Vannucchi AM, Guidi S, Guglielmelli P, Glinz S, Lombardini L, Busca A, Locatelli F, Dall'Omo AM, Bosi A
  Bone Marrow Transplant. 2007
  PubMed ID: 17846597
   
  
• Transforming growth factor beta-producing Foxp3(+)CD8(+)CD25(+) T cells induced by iris pigment epithelial cells display regulatory phenotype and acquire regulatory functions.
  Sugita S, Futagami Y, Horie S, Mochizuki M
  Exp Eye Res. 2007
  PubMed ID: 17720157
   
  
• Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells.
  Li R, Perez N, Karumuthil-Melethil S, Prabhakar BS, Holterman MJ, Vasu C
  J Immunol. 2007
  PubMed ID: 17911604
   
  
• Diminished myelin-specific T cell activation associated with increase in CTLA4 and Fas molecules in multiple sclerosis patients treated with IFN-beta.
  Hallal-Longo DE, Mirandola SR, Oliveira EC, Farias AS, Pereira FG, Metze IL, Brandão CO, Ruocco HH, Damasceno BP, Santos LM
  J Interferon Cytokine Res. 2007
  PubMed ID: 17970696
   
  
• CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo.
  Taylor MD, Harris A, Babayan SA, Bain O, Culshaw A, Allen JE, Maizels RM
  J Immunol. 2007
  PubMed ID: 17878360
   
  
• 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.
  Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A
  Nat Immunol. 2007
  PubMed ID: 17873878
   
  
• Genetic analyses of celiac disease in a Spanish population confirm association with CELIAC3 but not with CELIAC4.
  Capilla A, Donat E, Planelles D, Espinós C, Ribes-Koninckx C, Palau F
  Tissue Antigens. 2007
  PubMed ID: 17767555
   
  
• ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
  Joshi AD, Hegde GV, Dickinson JD, Mittal AK, Lynch JC, Eudy JD, Armitage JO, Bierman PJ, Bociek RG, Devetten MP, Vose JM, Joshi SS
  Clin Cancer Res. 2007
  PubMed ID: 17875758
   
  
• CD45RB ligation inhibits allergic pulmonary inflammation by inducing CTLA4 transcription.
  Jen KY, Campo M, He H, Makani SS, Velasco G, Rothstein DM, Perkins DL, Finn PW
  J Immunol. 2007
  PubMed ID: 17785861
   
  
• Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter.
  Gibson HM, Hedgcock CJ, Aufiero BM, Wilson AJ, Hafner MS, Tsokos GC, Wong HK
  J Immunol. 2007
  PubMed ID: 17785820
   
  
• Molecular determinants of inverse agonist activity of biologicals targeting CTLA-4.
  Teft WA, Madrenas J
  J Immunol. 2007
  PubMed ID: 17785798
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
  Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
  J Infect Dis. 2007
  PubMed ID: 17703412
   
  
• [Role of CD28/CTLA-4 co-stimulators in immune pathophysiology of aplastic anemia]
  He GS, Zhou L, Wu DP, Sun AN, Miao M, Wang XL, Chang WR, Zhu ZL, Jin ZM, Qiu HY, Tang XW, Fu ZZ, Han Y, Ma X, Chen SN, Wu XJ
  Zhonghua Xue Ye Xue Za Zhi. 2007
  PubMed ID: 18246813
   
  
• T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis.
  Chang MC, Chang YT, Tien YW, Liang PC, Jan IS, Wei SC, Wong JM
  Clin Chem. 2007
  PubMed ID: 17712006
   
  
• Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.
  Tai X, Van Laethem F, Sharpe AH, Singer A
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17702861
   
  
• CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes.
  Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A
  Circ Res. 2007
  PubMed ID: 17569889
   
  
• High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer.
  Cozar JM, Romero JM, Aptsiauri N, Vazquez F, Vilchez JR, Tallada M, Garrido F, Ruiz-Cabello F
  Hum Immunol. 2007
  PubMed ID: 17678726
   
  
• Cytotoxic T lymphocyte antigen 4 gene polymorphism associated with ST-segment elevation acute myocardial infarction.
  Yip HK, Wang PW, Chang LT, Youssef AA, Sheu JJ, Lee FY, Wu CJ
  Circ J. 2007
  PubMed ID: 17652883
   
  
• Cytotoxic T-lymphocyte associated antigen 4 gene polymorphisms and autoimmune thyroid disease: a meta-analysis.
  Kavvoura FK, Akamizu T, Awata T, Ban Y, Chistiakov DA, Frydecka I, Ghaderi A, Gough SC, Hiromatsu Y, Ploski R, Wang PW, Ban Y, Bednarczuk T, Chistiakova EI, Chojm M, Heward JM, Hiratani H, Juo SH, Karabon L, Katayama S, Kurihara S, Liu RT, Miyake I, Omrani GH, Pawlak E, Taniyama M, Tozaki T, Ioannidis JP
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17504905
   
  
• Foxp3+CD25+ T regulatory cells stimulate IFN-gamma-independent CD152-mediated activation of tryptophan catabolism that provides dendritic cells with immune regulatory activity in mice unresponsive to staphylococcal enterotoxin B.
  Feunou P, Vanwetswinkel S, Gaudray F, Goldman M, Matthys P, Braun MY
  J Immunol. 2007
  PubMed ID: 17617582
   
  
• CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase.
  Wei B, da Rocha Dias S, Wang H, Rudd CE
  J Immunol. 2007
  PubMed ID: 17579061
   
  
• CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland.
  Heggarty S, Suppiah V, Silversides J, O'doherty C, Droogan A, McDonnell G, Hawkins S, Graham C, Vandenbroeck K
  J Neuroimmunol. 2007
  PubMed ID: 17524498
   
  
• Susceptibility genes in Graves' ophthalmopathy: searching for a needle in a haystack?
  Bednarczuk T, Gopinath B, Ploski R, Wall JR
  Clin Endocrinol (Oxf). 2007
  PubMed ID: 17521325
   
  
• CTLA-4 blockade in murine bone marrow chimeras induces a host-derived antileukemic effect without graft-versus-host disease.
  Fevery S, Billiau AD, Sprangers B, Rutgeerts O, Lenaerts C, Goebels J, Landuyt W, Kasran A, Boon L, Sagaert X, De Wolf-Peeters C, Waer M, Vandenberghe P
  Leukemia. 2007
  PubMed ID: 17508005
   
  
• Association of -318 C/T and +49 A/G cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms with a clinical subset of Italian patients with systemic sclerosis.
  Balbi G, Ferrera F, Rizzi M, Piccioli P, Morabito A, Cardamone L, Ghio M, Palmisano GL, Carrara P, Pedemonte S, Sessarego M, De Angioletti M, Notaro R, Indiveri F, Pistillo MP
  Clin Exp Immunol. 2007
  PubMed ID: 17459075
   
  
• Cytotoxic T lymphocyte-associated molecule-4 gene polymorphism and hyperthyroid Graves' disease relapse after antithyroid drug withdrawal: a follow-up study.
  Wang PW, Chen IY, Liu RT, Hsieh CJ, Hsi E, Juo SH
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17426089
   
  
• CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.
  Pérez-García A, De la Cámara R, Román-Gómez J, Jiménez-Velasco A, Encuentra M, Nieto JB, de la Rubia J, Urbano-Ispizúa A, Brunet S, Iriondo A, González M, Serrano D, Espigado I, Solano C, Ribera JM, Pujal JM, Hoyos M, Gallardo D, GVHD/Immunotherapy Committee of the Spanish Group of Hematopoietic Stem Cell Transplantation
  Blood. 2007
  PubMed ID: 17384200
   
  
• Role for CTLA-4 but not CD25+ T cells during Schistosoma mansoni infection of mice.
  Walsh CM, Smith P, Fallon PG
  Parasite Immunol. 2007
  PubMed ID: 17518948
   
  
• The CD28/CTLA-4-B7 signaling pathway is involved in both allergic sensitization and tolerance induction to orally administered peanut proteins.
  van Wijk F, Nierkens S, de Jong W, Wehrens EJ, Boon L, van Kooten P, Knippels LM, Pieters R
  J Immunol. 2007
  PubMed ID: 17513738
   
  
• Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis.
  Donaldson P, Veeramani S, Baragiotta A, Floreani A, Venturi C, Pearce S, Wilson V, Jones D, James O, Taylor J, Newton J, Bassendine M
  Clin Gastroenterol Hepatol. 2007
  PubMed ID: 17482523
   
  
• Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children.
  Sohn MH, Kim SH, Song TW, Kim KW, Kim ES, Park HS, Kim KE
  Pediatr Pulmonol. 2007
  PubMed ID: 17469155
   
  
• CTLA-4 gene and susceptibility to human papillomavirus-16-associated cervical squamous cell carcinoma in Taiwanese women.
  Su TH, Chang TY, Lee YJ, Chen CK, Liu HF, Chu CC, Lin M, Wang PT, Huang WC, Chen TC, Yang YC
  Carcinogenesis. 2007
  PubMed ID: 17341658
   
  
• The CTLA-4 -1661A/G and -1772T/C dimorphisms in Japanese patients with systemic sclerosis.
  Takeuchi F, Nakaue N, Kawasugi K, Mori M, Kuwata S, Tanimoto K
  Rheumatol Int. 2007
  PubMed ID: 17225925
   
  
• Interaction of maternal atopy, CTLA-4 gene polymorphism and gender on antenatal immunoglobulin E production.
  Yang KD, Ou CY, Hsu TY, Chang JC, Chuang H, Liu CA, Liang HM, Kuo HC, Chen RF, Huang EY
  Clin Exp Allergy. 2007
  PubMed ID: 17456215
   
  
• CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.
  Jackman RP, Balamuth F, Bottomly K
  J Immunol. 2007
  PubMed ID: 17442936
   
  
• Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
  Chikuma S, Bluestone JA
  Eur J Immunol. 2007
  PubMed ID: 17429849
   
  
• Pivotal advance: CTLA-4+ T cells exhibit normal antiviral functions during acute viral infection.
  Raué HP, Slifka MK
  J Leukoc Biol. 2007
  PubMed ID: 17215523
   
  
• No association of the cytotoxic T-lymphocyte associated gene CTLA4 +49A/G polymorphisms with Crohn's disease and ulcerative colitis in Hungarian population samples.
  Magyari L, Faragó B, Bene J, Horvatovich K, Lakner L, Varga M, Figler M, Gasztonyi B, Mózsik G, Melegh B
  World J Gastroenterol. 2007
  PubMed ID: 17465502
   
  
• [The implications of nasal associated lymphoid tissue in development of respiratory allergic diseases in children].
  Zakrzewska A, Kobos J, Górski P
  Med Wieku Rozwoj. 2007
  PubMed ID: 17625281
   
  
• No evidence for association of CTLA-4 gene polymorphisms with the risk of developing multiple sclerosis: a meta-analysis.
  Bagos PG, Karnaouri AC, Nikolopoulos GK, Hamodrakas SJ
  Mult Scler. 2007
  PubMed ID: 17439880
   
  
• Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection.
  Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, Wiedenmann B, Berg T
  J Hepatol. 2007
  PubMed ID: 17150279
   
  
• Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function.
  Venkatachari NJ, Majumder B, Ayyavoo V
  Virology. 2007
  PubMed ID: 17023015
   
  
• High IFN-gamma production of individual CD8 T lymphocytes is controlled by CD152 (CTLA-4).
  Pandiyan P, Hegel JK, Krueger M, Quandt D, Brunner-Weinzierl MC
  J Immunol. 2007
  PubMed ID: 17277117
   
  
• Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease.
  Gunesacar R, Erken E, Bozkurt B, Ozer HT, Dinkci S, Erken EG, Ozbalkan Z
  Int J Immunogenet. 2007
  PubMed ID: 17284227
   
  
• Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A.
  Astermark J, Wang X, Oldenburg J, Berntorp E, Lefvert AK, MIBS Study Group
  J Thromb Haemost. 2007
  PubMed ID: 17269936
   
  
• B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.
  May KF, Chang X, Zhang H, Lute KD, Zhou P, Kocak E, Zheng P, Liu Y
  J Immunol. 2007
  PubMed ID: 17237403
   
  
• Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice.
  Hubeau C, Apostolou I, Kobzik L
  J Immunol. 2007
  PubMed ID: 17237396
   
  
• Production and characterization of human CTLA4Ig expressed in transgenic rice cell suspension cultures.
  Lee SJ, Park CI, Park MY, Jung HS, Ryu WS, Lim SM, Tan HK, Kwon TH, Yang MS, Kim DI
  Protein Expr Purif. 2007
  PubMed ID: 17079164
   
  
• Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms.
  Raitala A, Karjalainen J, Oja SS, Kosunen TU, Hurme M
  Mol Immunol. 2007
  PubMed ID: 16620985
   
  
• Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
  Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17197413
   
  
• Case-control association analysis of rheumatoid arthritis with candidate genes using related cases.
  Yoo YJ, Gao G, Zhang K
  BMC Proc. 2007
  PubMed ID: 18466531
   
  
• Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
  Mei L, Li X, Yang K, Cui J, Fang B, Guo X, Rotter JI
  BMC Proc. 2007
  PubMed ID: 18466513
   
  
• Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population.
  Wang L, Li D, Fu Z, Li H, Jiang W, Li D
  BMC Cancer. 2007
  PubMed ID: 17825114
   
  
• Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.
  Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN
  Adv Exp Med Biol. 2007
  PubMed ID: 17712998
   
  
• CTLA-4 +49A/G and CT60 gene polymorphisms in primary Sjögren syndrome.
  Gottenberg JE, Loiseau P, Azarian M, Chen C, Cagnard N, Hachulla E, Puechal X, Sibilia J, Charron D, Mariette X, Miceli-Richard C
  Arthritis Res Ther. 2007
  PubMed ID: 17341301
   
  
• A suggestive association of fuchs heterochromic cyclitis with cytotoxic T cell antigen 4 gene polymorphism.
  Spriewald BM, Lefter C, Huber I, Lauer B, Wenkel H
  Ophthalmic Res. 2007
  PubMed ID: 17287608
   
  
• CTLA-4 gene exon-1 +49 A/G polymorphism: lack of association with autoimmune disease in patients with common variable immune deficiency.
  Knight AK, Serrano D, Tomer Y, Cunningham-Rundles C
  J Clin Immunol. 2007
  PubMed ID: 17192819
   
  
• The net effect of costimulatory blockers is dependent on the subset and activation status of the autoreactive T cells.
  Zhang P, Sun D, Ke Y, Kaplan HJ, Shao H
  J Immunol. 2007
  PubMed ID: 17182586
   
  
• The predictive value of CTLA-4 and Tg polymorphisms in the recurrence of Graves' disease after antithyroid withdrawal.
  Tanrikulu S, Erbil Y, Ademoglu E, Işsever H, Barbaros U, Kutlutürk F, Ozarmagan S, Tezelman S
  Endocrine. 2006
  PubMed ID: 17526951
   
  
• Possible association of cytotoxic T lymphocyte antigen-4 genetic polymorphism with liver damage of primary biliary cirrhosis in Japan.
  Kanno Y, Rai T, Monoe K, Saito H, Takahashi A, Irisawa A, Ohira H
  Fukushima J Med Sci. 2006
  PubMed ID: 17427759
   
  
• [Susceptibility genes for the development of autoimmune thyroid disease]
  Shirasawa S
  Nippon Rinsho. 2006
  PubMed ID: 17154080
   
  
• B7+ iris pigment epithelial cells convert T cells into CTLA-4+, B7-expressing CD8+ regulatory T cells.
  Sugita S, Keino H, Futagami Y, Takase H, Mochizuki M, Stein-Streilein J, Streilein JW
  Invest Ophthalmol Vis Sci. 2006
  PubMed ID: 17122127
   
  
• CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent.
  Gattinoni L, Ranganathan A, Surman DR, Palmer DC, Antony PA, Theoret MR, Heimann DM, Rosenberg SA, Restifo NP
  Blood. 2006
  PubMed ID: 16882704
   
  
• TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression.
  Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Wälter S, Sabat R, Schülein R, Wiesner B, Veh RW, Löhler J, Blumberg RS, Volk HD, Utku N
  J Immunol. 2006
  PubMed ID: 17082597
   
  
• Risk of adverse post-transplant events after kidney allograft transplantation as predicted by CTLA-4 +49 and TNF-alpha -308 single nucleotide polymorphisms: a preliminary study.
  Gendzekhadze K, Rivas-Vetencourt P, Montano RF
  Transpl Immunol. 2006
  PubMed ID: 17138053
   
  
• Association of Graves' disease and Graves' ophthalmopathy with the polymorphisms in promoter and exon 1 of cytotoxic T lymphocyte associated antigen-4 gene.
  Zhang Q, Yang YM, Lv XY
  J Zhejiang Univ Sci B. 2006
  PubMed ID: 17048303
   
  
• Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study.
  Graham DS, Wong AK, McHugh NJ, Whittaker JC, Vyse TJ
  Hum Mol Genet. 2006
  PubMed ID: 17000707
   
  
• Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signaling.
  Bharat A, Fields RC, Trulock EP, Patterson GA, Mohanakumar T
  J Immunol. 2006
  PubMed ID: 17015751
   
  
• Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis.
  Furze RC, Culley FJ, Selkirk ME
  Microbes Infect. 2006
  PubMed ID: 17045510
   
  
• Infection of CD127+ (interleukin-7 receptor+) CD4+ cells and overexpression of CTLA-4 are linked to loss of antigen-specific CD4 T cells during primary human immunodeficiency virus type 1 infection.
  Zaunders JJ, Ip S, Munier ML, Kaufmann DE, Suzuki K, Brereton C, Sasson SC, Seddiki N, Koelsch K, Landay A, Grey P, Finlayson R, Kaldor J, Rosenberg ES, Walker BD, Fazekas de St Groth B, Cooper DA, Kelleher AD
  J Virol. 2006
  PubMed ID: 17005693
   
  
• The influence of CTLA-4 gene polymorphisms on liver transplant outcomes.
  Perkins JD
  Liver Transpl. 2006
  PubMed ID: 17004266
   
  
• Reversal of the TCR stop signal by CTLA-4.
  Schneider H, Downey J, Smith A, Zinselmeyer BH, Rush C, Brewer JM, Wei B, Hogg N, Garside P, Rudd CE
  Science. 2006
  PubMed ID: 16931720
   
  
• Ctla-4 exon 1 (+49) and promoter (-318) gene polymorphisms in kidney transplantation.
  Gorgi Y, Sfar I, Abdallah TB, Abderrahim E, Ayed SJ, Aouadi H, Bardi R, Ayed K
  Transplant Proc. 2006
  PubMed ID: 16980072
   
  
• Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem).
  Pavoni DP, Cerqueira LB, Roxo VM, Petzl-Erler ML
  Braz J Med Biol Res. 2006
  PubMed ID: 16972006
   
  
• TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling.
  Oida T, Xu L, Weiner HL, Kitani A, Strober W
  J Immunol. 2006
  PubMed ID: 16887994
   
  
• CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis.
  Han S, Zhang S, Zhang W, Li R, Li Y, Wang Z, Xie Y, Mao Y
  Hum Immunol. 2006
  PubMed ID: 16916658
   
  
• The common -318C/T polymorphism in the promoter region of CTLA4 gene is associated with reduced risk of ophthalmopathy in Chinese Graves' patients.
  Han SZ, Zhang SH, Li R, Zhang WY, Li Y
  Int J Immunogenet. 2006
  PubMed ID: 16893393
   
  
• Influence of CTLA4 haplotypes on susceptibility and some extraglandular manifestations in primary Sjögren's syndrome.
  Downie-Doyle S, Bayat N, Rischmueller M, Lester S
  Arthritis Rheum. 2006
  PubMed ID: 16869018
   
  
• Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression.
  Shao W, Lazaryan A, Dorak MT, Penman-Aguilar A, Wilson CM, Margolick JB, Goedert JJ, Prins M, Tang J, Kaslow RA
  AIDS. 2006
  PubMed ID: 16868438
   
  
• Migration and function of FoxP3+ regulatory T cells in the hematolymphoid system.
  Kim CH
  Exp Hematol. 2006
  PubMed ID: 16863909
   
  
• Association of polymorphisms in CTLA-4, IL-1ra and IL-1beta genes with multiple sclerosis in Serbian population.
  Dincić E, Zivković M, Stanković A, Obradović D, Alavantić D, Kostić V, Raicević R
  J Neuroimmunol. 2006
  PubMed ID: 16769128
   
  
• Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma.
  Cheng TY, Lin JT, Chen LT, Shun CT, Wang HP, Lin MT, Wang TE, Cheng AL, Wu MS
  J Clin Oncol. 2006
  PubMed ID: 16849765
   
  
• CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism.
  Engelhardt JJ, Sullivan TJ, Allison JP
  J Immunol. 2006
  PubMed ID: 16818761
   
  
• Association of CTLA-4 gene promoter polymorphisms with systemic sclerosis in Iranian population.
  Almasi S, Erfani N, Mojtahedi Z, Rajaee A, Ghaderi A
  Genes Immun. 2006
  PubMed ID: 16775619
   
  
• [Cytotoxic T lymphocyte antigen-4 promoter gene polymorphism is significantly associated with ulcerative colitis]
  Zhou F, Xia B, Guo QS, Wang Q, Li L, Jiang L, Cheng H
  Zhonghua Nei Ke Za Zhi. 2006
  PubMed ID: 16831326
   
  
• Prolongation of renal allograft survival in rats by replication-defective recombinant adenovirus-mediated coexpression of CD40L and CTLA4Ig.
  Tian PX, Li ZL, Zhang YS, Xue WJ, Wu J
  Transplant Proc. 2006
  PubMed ID: 16797372
   
  
• High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice.
  Behnke JM, Iraqi FA, Mugambi JM, Clifford S, Nagda S, Wakelin D, Kemp SJ, Baker RL, Gibson JP
  Mamm Genome. 2006
  PubMed ID: 16783640
   
  
• Cytotoxic T lymphocyte antigen-4-dependent down-modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T-cell-mediated suppression.
  Oderup C, Cederbom L, Makowska A, Cilio CM, Ivars F
  Immunology. 2006
  PubMed ID: 16771859
   
  
• [Study on association of CTLA4 gene polymorphism with Grave's disease in Guangxi Zhuang nationality population]
  Liang XH, Qin YF, Ma Y, Xie XR, Xie KQ, Luo ZJ
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
  PubMed ID: 16767670
   
  
• CTLA-4 gene polymorphisms and natural soluble CTLA-4 protein in psoriasis vulgaris.
  Luszczek W, Kubicka W, Jasek M, Baran E, Cisło M, Nockowski P, Luczywo-Rudy M, Wiśniewski A, Nowak I, Kuśnierczyk P
  Int J Immunogenet. 2006
  PubMed ID: 16712655
   
  
• Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.
  Manzotti CN, Liu MK, Burke F, Dussably L, Zheng Y, Sansom DM
  Eur J Immunol. 2006
  PubMed ID: 16708397
   
  
• Polymorphisms in the T cell regulatory gene cytotoxic T lymphocyte antigen 4 influence the rate of acute rejection after liver transplantation.
  Tapirdamaz O, Pravica V, Metselaar HJ, Hansen B, Moons L, van Meurs JB, Hutchinson IV, Shaw J, Agarwal K, Adams DH, Day CP, Kwekkeboom J
  Gut. 2006
  PubMed ID: 16299026
   
  
• Exon-1 polymorphism of ctla-4 gene is not associated with systemic sclerosis in Iranian patients.
  Rajaee A, Ebrahimi A, Ghiam AF, Kalantari T, Ghaderi A
  Rheumatol Int. 2006
  PubMed ID: 16189655
   
  
• Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07.
  Kula D, Bednarczuk T, Jurecka-Lubieniecka B, Polanska J, Hasse-Lazar K, Jarzab M, Steinhof-Radwanska K, Hejduk B, Zebracka J, Kurylowicz A, Bar-Andziak E, Stechly T, Pawlaczek A, Gubala E, Krawczyk A, Szpak-Ulczok S, Nauman J, Jarzab B
  Thyroid. 2006
  PubMed ID: 16756466
   
  
• Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients.
  Jiang Y, Xia B, Jiang L, Lv M, Guo Q, Chen M, Li J, Xia HH, Wong BC
  Inflamm Bowel Dis. 2006
  PubMed ID: 16670525
   
  
• No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.
  Wiencke K, Boberg KM, Donaldson P, Harbo H, Ling V, Schrumpf E, Spurkland A
  Scand J Gastroenterol. 2006
  PubMed ID: 16638702
   
  
• Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infection.
  Anderson KM, Czinn SJ, Redline RW, Blanchard TG
  J Immunol. 2006
  PubMed ID: 16621997
   
  
• CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade.
  Coenen JJ, Koenen HJ, van Rijssen E, Boon L, Joosten I, Hilbrands LB
  J Immunol. 2006
  PubMed ID: 16621989
   
  
• Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss.
  Wang X, Ma Z, Hong Y, Lu P, Lin Q
  Int J Gynaecol Obstet. 2006
  PubMed ID: 16564528
   
  
• Reduced function of CD4+25+ regulatory T cell fraction in silicosis patients.
  Wu P, Miura Y, Hyodoh F, Nishimura Y, Hatayama T, Hatada S, Sakaguchi H, Kusaka M, Katsuyama H, Tomita M, Otsuki T
  Int J Immunopathol Pharmacol. 2006
  PubMed ID: 16831302
   
  
• Thyroid autoantibody production is influenced by exon 1 and promoter CTLA-4 polymorphisms in patients with Hashimoto's thyroiditis.
  Zaletel K, Krhin B, Gaberscek S, Hojker S
  Int J Immunogenet. 2006
  PubMed ID: 16611252
   
  
• [The research on associating the single nucleotide polymorphism of CTLA-4 gene promoter region with idiopathic dilated cardiomyopathy]
  Liu W, Li WM, Gao C, Li Y, Kong YH
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
  PubMed ID: 16604497
   
  
• The CTLA4+49A/G and CT60 polymorphisms and chronic inflammatory arthropathies in Northern Ireland.
  Suppiah V, O'Doherty C, Heggarty S, Patterson CC, Rooney M, Vandenbroeck K
  Exp Mol Pathol. 2006
  PubMed ID: 16248997
   
  
• TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells.
  Zheng SG, Wang JH, Stohl W, Kim KS, Gray JD, Horwitz DA
  J Immunol. 2006
  PubMed ID: 16517699
   
  
• The genetic contribution of CTLA-4 dimorphisms in promoter and exon 1 regions in Japanese patients with rheumatoid arthritis.
  Takeuchi F, Kawasugi K, Mori M, Nakaue N, Kobayashi N, Kuwata S, Murayama T, Matsuta K
  Scand J Rheumatol. 2006
  PubMed ID: 16641053
   
  
• [A/G polymorphism at position 49 in exon 1 of CTLA-4 gene in Chinese women with unexplained recurrent spontaneous abortion]
  Wang XP, Lin QD, Ma ZW, Hong Y, Zhao AM, Di W, Lu PH
  Zhonghua Fu Chan Ke Za Zhi. 2006
  PubMed ID: 16640877
   
  
• Lack of a genetic association between the CTLA-4 gene and Graves' disease in Koreans.
  Cho HJ, Chung JH, Kim IS, Kim HJ, Cho SH, Ki CS, Kim JW
  Thyroid. 2006
  PubMed ID: 16571085
   
  
• Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer.
  Erfani N, Razmkhah M, Talei AR, Pezeshki AM, Doroudchi M, Monabati A, Ghaderi A
  Cancer Genet Cytogenet. 2006
  PubMed ID: 16527605
   
  
• No association between selected candidate gene polymorphisms and severe chronic periodontitis.
  Wohlfahrt JC, Wu T, Hodges JS, Hinrichs JE, Michalowicz BS
  J Periodontol. 2006
  PubMed ID: 16512757
   
  
• CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.
  Srahna M, Van Grunsven LA, Remacle JE, Vandenberghe P
  Immunology. 2006
  PubMed ID: 16476059
   
  
• Polymorphisms within the CTLA4 gene are associated with infant atopic dermatitis.
  Jones G, Wu S, Jang N, Fulcher D, Hogan P, Stewart G
  Br J Dermatol. 2006
  PubMed ID: 16445777
   
  
• The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan.
  Ikegami H, Awata T, Kawasaki E, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Amemiya S, Kawabata Y, Kurihara S, Tanaka S, Kanazawa Y, Mochizuki M, Ogihara T
  J Clin Endocrinol Metab. 2006
  PubMed ID: 16352685
   
  
• [CD28 and CTLA-4 costimulatory molecules expression on T lymphocytes and NK cells in nonallergic bronchial asthma].
  Rutkowski R, Stasiak-Barmuta A, Moniuszko T, Rutkowska-Rogacz D, Woińska M, Rutkowski K, Sidorczuk M
  Pol Merkur Lekarski. 2006
  PubMed ID: 16708626
   
  
• [Effects and mechanism of CD4+ CD25+ T cells on the airway inflammation of asthmatic mice].
  Sun K, Lin KX, Wu K, Wang CZ
  Zhonghua Jie He He Hu Xi Za Zhi. 2006
  PubMed ID: 16677453
   
  
• Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis.
  Lankarani KB, Karbasi A, Kalantari T, Yarmohammadi H, Saberi-Firoozi M, Alizadeh-Naeeni M, Taghavi AR, Fattahi MR, Ghaderi A
  J Gastroenterol Hepatol. 2006
  PubMed ID: 16509873
   
  
• CTLA-4 lacking the cytoplasmic domain costimulates IL-2 production in T-cell hybridomas.
  Hueber AJ, Matzkies FG, Rahmeh M, Manger B, Kalden JR, Nagel T
  Immunol Cell Biol. 2006
  PubMed ID: 16405652
   
  
• Cytotoxic T-lymphocyte antigen 4 gene polymorphisms and susceptibility to chronic hepatitis B.
  Mohammad Alizadeh AH, Hajilooi M, Ranjbar M, Fallahian F, Mousavi SM
  World J Gastroenterol. 2006
  PubMed ID: 16489681
   
  
• [The frequency of CTLA-4 gene polymorphism at position 49 exon 1 in children with Hashimoto's thyroiditis]
  Kucharska A, Wiśniewska A, Rymkiewicz-Kluczyńska B
  Endokrynol Diabetol Chor Przemiany Materii Wieku R. 2006
  PubMed ID: 17020648
   
  
• Distribution of CTLA-4 polymorphisms in allergic asthma.
  Jasek M, Łuszczek W, Obojski A, Winiarska B, Hałubek K, Nowak I, Mańczak M, Wiśniewski A, Pawlik A, Jonkisz A, Lebioda A, Majorczyk E, Dobosz T, Kuśnierczyk P
  Int Arch Allergy Immunol. 2006
  PubMed ID: 16926542
   
  
• Effects of cytotoxic T lymphocyte antigen 4 (CTLA4) signaling and locally applied steroid on retinal dysfunction by recoverin, cancer-associated retinopathy antigen.
  Maeda A, Maeda T, Liang Y, Yenerel M, Saperstein DA
  Mol Vis. 2006
  PubMed ID: 16917481
   
  
• Three allele combinations associated with multiple sclerosis.
  Favorova OO, Favorov AV, Boiko AN, Andreewski TV, Sudomoina MA, Alekseenkov AD, Kulakova OG, Gusev EI, Parmigiani G, Ochs MF
  BMC Med Genet. 2006
  PubMed ID: 16872485
   
  
• CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.
  Schneider H, Valk E, Dias Sda R, Wei B, Rudd CE
  Adv Exp Med Biol. 2006
  PubMed ID: 16802603
   
  
• A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis.
  Schubert K, von Bonnsdorf H, Burke M, Ahlert I, Braun S, Berner R, Deichmann KA, Heinzmann A
  Dis Markers. 2006
  PubMed ID: 16788246
   
  
• A molecular perspective of CTLA-4 function.
  Teft WA, Kirchhof MG, Madrenas J
  Annu Rev Immunol. 2006
  PubMed ID: 16551244
   
  
• Possible association of cytotoxic T-lymphocyte antigen 4 gene promoter single nucleotide polymorphism with acute rejection of allogeneic kidney transplant.
  Wiśniewski A, Kusztal M, Magott-Procelewska M, Klinger M, Jasek M, Łuszczek W, Nowak I, Kosmaczewska A, Ciszak L, Frydecka I, Górski A, Kuśnierczyk P
  Transplant Proc. 2006
  PubMed ID: 16504663
   
  
• Increased expression of CTLA-4 in malignant T-cells from patients with mycosis fungoides -- cutaneous T cell lymphoma.
  Wong HK, Wilson AJ, Gibson HM, Hafner MS, Hedgcock CJ, Berger CL, Edelson RL, Lim HW
  J Invest Dermatol. 2006
  PubMed ID: 16417239
   
  
• Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma.
  Wong YK, Chang KW, Cheng CY, Liu CJ
  J Oral Pathol Med. 2006
  PubMed ID: 16393254
   
  
• B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells.
  Sugita S, Ng TF, Lucas PJ, Gress RE, Streilein JW
  J Immunol. 2006
  PubMed ID: 16365402
   
  
• Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.
  Brophy K, Ryan AW, Thornton JM, Abuzakouk M, Fitzgerald AP, McLoughlin RM, O'morain C, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R
  Genes Immun. 2006
  PubMed ID: 16237465
   
  
• Immune response gene polymorphisms in renal transplant recipients.
  Dmitrienko S, Hoar DI, Balshaw R, Keown PA
  Transplantation. 2005
  PubMed ID: 16378074
   
  
• Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
  Plenge RM, Padyukov L, Remmers EF, Purcell S, Lee AT, Karlson EW, Wolfe F, Kastner DL, Alfredsson L, Altshuler D, Gregersen PK, Klareskog L, Rioux JD
  Am J Hum Genet. 2005
  PubMed ID: 16380915
   
  
• [Relationship of CTLA-4 exon 1 A49-->G polymorphism with sCTLA-4 and Th1/Th2 bias in idiopathic dilated cardiomyopathy]
  Liu W, Li WM, Gao C, Wang XR, Li DM, Sun NL
  Zhonghua Yi Xue Za Zhi. 2005
  PubMed ID: 16405845
   
  
• Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance.
  Alenmyr L, Matheu V, Uller L, Greiff L, Malm-Erjefält M, Ljunggren HG, Persson CG, Korsgren M
  Scand J Immunol. 2005
  PubMed ID: 16305640
   
  
• A function for interleukin 2 in Foxp3-expressing regulatory T cells.
  Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY
  Nat Immunol. 2005
  PubMed ID: 16227984
   
  
• CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.
  Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, Kobayashi SV, Linsley PS, Thompson CB, Riley JL
  Mol Cell Biol. 2005
  PubMed ID: 16227604
   
  
• Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies.
  Lute KD, May KF, Lu P, Zhang H, Kocak E, Mosinger B, Wolford C, Phillips G, Caligiuri MA, Zheng P, Liu Y
  Blood. 2005
  PubMed ID: 16037385
   
  
• Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression.
  Tan PH, Yates JB, Xue SA, Chan C, Jordan WJ, Harper JE, Watson MP, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJ
  Blood. 2005
  PubMed ID: 15994283
   
  
• HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?
  Brand O, Gough S, Heward J
  Expert Rev Mol Med. 2005
  PubMed ID: 16229750
   
  
• Variants of the CTLA4 gene that segregate with autoimmune diseases are not associated with endometriosis.
  Viganó P, Lattuada D, Somigliana E, Abbiati A, Candiani M, Di Blasio AM
  Mol Hum Reprod. 2005
  PubMed ID: 16373368
   
  
• Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease.
  Kurylowicz A, Kula D, Ploski R, Skorka A, Jurecka-Lubieniecka B, Zebracka J, Steinhof-Radwanska K, Hasse-Lazar K, Hiromatsu Y, Jarzab B, Bednarczuk T
  Thyroid. 2005
  PubMed ID: 16279844
   
  
• A CTLA4high genotype is associated with myasthenia gravis in thymoma patients.
  Chuang WY, Ströbel P, Gold R, Nix W, Schalke B, Kiefer R, Opitz A, Klinker E, Müller-Hermelink HK, Marx A
  Ann Neurol. 2005
  PubMed ID: 16178018
   
  
• Virus attachment and replication are promoted after acquisition of host CD28 and CD152 by HIV-1.
  Giguere JF, Diou J, Madrenas J, Tremblay MJ
  J Infect Dis. 2005
  PubMed ID: 16136471
   
  
• Meta-analysis of the association of CTLA-4 exon-1 +49A/G polymorphism with rheumatoid arthritis.
  Han S, Li Y, Mao Y, Xie Y
  Hum Genet. 2005
  PubMed ID: 16133179
   
  
• Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune responses to trinitrophenyl-ovalbumin.
  Nierkens S, Aalbers M, Bol M, Bleumink R, van Kooten P, Boon L, Pieters R
  J Immunol. 2005
  PubMed ID: 16148116
   
  
• CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
  Schneider H, Valk E, da Rocha Dias S, Wei B, Rudd CE
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16126897
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Cytotoxic T lymphocyte antigen 4 polymorphism 49 (A>G) and migraine.
  Lulli P, Trabace S, Morellini M, Cicciarelli G, Coloprisco G, Piane M, de Filippis S, Santi PG, Avramakou O, Ferlicca E, Martelletti P
  J Headache Pain. 2005
  PubMed ID: 16362660
   
  
• Prevention of experimental autoimmune myocarditis by hydrodynamics-based naked plasmid DNA encoding CTLA4-Ig gene delivery.
  Abe S, Hanawa H, Hayashi M, Yoshida T, Komura S, Watanabe R, Lie H, Chang H, Kato K, Kodama M, Maruyama H, Nakazawa M, Miyazaki J, Aizawa Y
  J Card Fail. 2005
  PubMed ID: 16198253
   
  
• Cytotoxic T lymphocyte-associated molecule-4 polymorphisms in Turkish Graves' disease patients and association with probability of remission after antithyroid therapy.
  Sahin M, Erdogan MF, Erdogan G
  Eur J Intern Med. 2005
  PubMed ID: 16137550
   
  
• CTLA-4 gene 49A/G polymorphism in Turkish patients with Behçet's disease.
  Sallakci N, Bacanli A, Coskun M, Yavuzer U, Alpsoy E, Yegin O
  Clin Exp Dermatol. 2005
  PubMed ID: 16045690
   
  
• Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.
  Lorentzen AR, Celius EG, Ekstrøm PO, Wiencke K, Lie BA, Myhr KM, Ling V, Thorsby E, Vartdal F, Spurkland A, Harbo HF
  J Neuroimmunol. 2005
  PubMed ID: 16005527
   
  
• CTLA-4 expression in T cells of patients with atopic dermatitis.
  Choi SY, Sohn MH, Kwon BC, Kim KE
  Pediatr Allergy Immunol. 2005
  PubMed ID: 16101935
   
  
• Association of polymorphic alleles of CTLA4 with inflammatory bowel disease in the Japanese.
  Machida H, Tsukamoto K, Wen CY, Narumi Y, Shikuwa S, Isomoto H, Takeshima F, Mizuta Y, Niikawa N, Murata I, Kohno S
  World J Gastroenterol. 2005
  PubMed ID: 16015687
   
  
• Hierarchical regulation of CTLA-4 dimer-based lattice formation and its biological relevance for T cell inactivation.
  Darlington PJ, Kirchhof MG, Criado G, Sondhi J, Madrenas J
  J Immunol. 2005
  PubMed ID: 16002699
   
  
• Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
  Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
  Hum Mol Genet. 2005
  PubMed ID: 15917267
   
  
• Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups.
  Guzman VB, Morgun A, Shulzhenko N, Mine KL, Gonçalves-Primo A, Musatti CC, Gerbase-Delima M
  Hum Immunol. 2005
  PubMed ID: 16112024
   
  
• CTLA-4 gene polymorphisms in Chinese patients with ulcerative colitis.
  Hou W, Xia B, Yuan A, Li J, Yang Z, Mao L
  Inflamm Bowel Dis. 2005
  PubMed ID: 15973119
   
  
• ICOS contributes to T cell expansion in CTLA-4 deficient mice.
  van Berkel ME, Schrijver EH, Hofhuis FM, Sharpe AH, Coyle AJ, Broeren CP, Tesselaar K, Oosterwegel MA
  J Immunol. 2005
  PubMed ID: 15972646
   
  
• B7-independent inhibition of T cells by CTLA-4.
  Chikuma S, Abbas AK, Bluestone JA
  J Immunol. 2005
  PubMed ID: 15972645
   
  
• Association of CTLA4 polymorphism with regulatory T cell frequency.
  Atabani SF, Thio CL, Divanovic S, Trompette A, Belkaid Y, Thomas DL, Karp CL
  Eur J Immunol. 2005
  PubMed ID: 15940668
   
  
• The CTLA4 +49 A/G*G-CT60*G haplotype is associated with susceptibility to multiple sclerosis in Flanders.
  Suppiah V, Alloza I, Heggarty S, Goris A, Dubois B, Carton H, Vandenbroeck K
  J Neuroimmunol. 2005
  PubMed ID: 15904974
   
  
• Association of the CTLA-4 gene with rheumatoid arthritis in Chinese Han population.
  Lei C, Dongqing Z, Yeqing S, Oaks MK, Lishan C, Jianzhong J, Jie Q, Fang D, Ningli L, Xinghai H, Daming R
  Eur J Hum Genet. 2005
  PubMed ID: 15841095
   
  
• CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A.
  Mukherjee S, Ahmed A, Nandi D
  J Leukoc Biol. 2005
  PubMed ID: 15788440
   
  
• Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA).
  Caputo M, Cerrone GE, López AP, Villalba A, Krochik GA, Cédola FN, Targovnik HM, Frechtel GD
  Autoimmunity. 2005
  PubMed ID: 16206510
   
  
• Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.
  Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, Bianchi A, Calvisi A, Curreli L, Gaviano E, Lai P, Murgia A, Latte GC, Noli A, Gabbas A
  Br J Haematol. 2005
  PubMed ID: 15953005
   
  
• Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset.
  Skórka A, Bednarczuk T, Bar-Andziak E, Nauman J, Ploski R
  Clin Endocrinol (Oxf). 2005
  PubMed ID: 15943829
   
  
• Intrinsic tolerance in autologous collagen-induced arthritis is generated by CD152-dependent CD4+ suppressor cells.
  Treschow AP, Bäcklund J, Holmdahl R, Issazadeh-Navikas S
  J Immunol. 2005
  PubMed ID: 15905514
   
  
• Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo.
  Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H, Sayegh MH, Najafian N
  J Immunol. 2005
  PubMed ID: 15905503
   
  
• Exon-3 polymorphism of CTLA-4 gene in Turkish patients with vitiligo.
  Itirli G, Pehlivan M, Alper S, Yüksel SE, Onay H, Ozkinay F, Pehlivan S
  J Dermatol Sci. 2005
  PubMed ID: 15888380
   
  
• Regulation of the small GTPase Rap1 and extracellular signal-regulated kinases by the costimulatory molecule CTLA-4.
  Dillon TJ, Carey KD, Wetzel SA, Parker DC, Stork PJ
  Mol Cell Biol. 2005
  PubMed ID: 15870282
   
  
• CTLA4 engagement is required for induction of murine liver transplant spontaneous tolerance.
  Li W, Zheng XX, Kuhr CS, Perkins JD
  Am J Transplant. 2005
  PubMed ID: 15816877
   
  
• CTLA-4 is important in maintaining long-term survival of cardiac allografts.
  Chandraker A, Huurman V, Hallett K, Yuan X, Tector AJ, Park CH, Lu E, Zavazava N, Oaks M
  Transplantation. 2005
  PubMed ID: 15849541
   
  
• Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.
  Mead KI, Zheng Y, Manzotti CN, Perry LC, Liu MK, Burke F, Powner DJ, Wakelam MJ, Sansom DM
  J Immunol. 2005
  PubMed ID: 15814706
   
  
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
  Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
  Nature. 2005
  PubMed ID: 15815621
   
  
• Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotype.
  Parks CG, Cooper GS, Hudson LL, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP
  Arthritis Rheum. 2005
  PubMed ID: 15818712
   
  
• CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.
  Lee YH, Harley JB, Nath SK
  Hum Genet. 2005
  PubMed ID: 15688186
   
  
• A common CTLA4 haplotype associated with coeliac disease.
  Hunt KA, McGovern DP, Kumar PJ, Ghosh S, Travis SP, Walters JR, Jewell DP, Playford RJ, van Heel DA
  Eur J Hum Genet. 2005
  PubMed ID: 15657618
   
  
• Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population.
  Ban Y, Tozaki T, Taniyama M, Tomita M, Ban Y
  Autoimmunity. 2005
  PubMed ID: 16040335
   
  
• CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer.
  Solerio E, Tappero G, Iannace L, Matullo G, Ayoubi M, Parziale A, Cicilano M, Sansoè G, Framarin L, Vineis P, Rosina F
  Dig Liver Dis. 2005
  PubMed ID: 15888281
   
  
• Cytotoxic T-lymphocyte antigen 4 gene polymorphisms in sarcoidosis patients.
  Hattori N, Niimi T, Sato S, Achiwa H, Maeda H, Oguri T, Bessho Y, Ito H, Shimizu S, Ueda R
  Sarcoidosis Vasc Diffuse Lung Dis. 2005
  PubMed ID: 15881277
   
  
• Soluble CTLA-4 in sera of patients with bronchial asthma.
  Shi HZ, Mo XY, Zhong XN
  J Asthma. 2005
  PubMed ID: 15871446
   
  
• The polymorphisms -318C>T in the promoter and 49A>G in exon 1 of CTLA4 and the risk of aplastic anemia in a Caucasian population.
  Svahn J, Capasso M, Lanciotti M, Marrone A, Haupt R, Bacigalupo A, Pongiglione C, Boschetto L, Longoni D, Pillon M, Pistorio A, Di Michele P, Iori AP, Calvillo M, Locasciulli A, Menna G, Riccardi R, Ramenghi U, Dufour C, Iolascon A
  Bone Marrow Transplant. 2005
  PubMed ID: 15812539
   
  
• CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population.
  Petrone A, Giorgi G, Galgani A, Alemanno I, Corsello SM, Signore A, Di Mario U, Nisticò L, Cascino I, Buzzetti R
  Thyroid. 2005
  PubMed ID: 15785242
   
  
• CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders.
  Rueda B, Zhernakova A, López-Nevot MA, Gomez-Garcia M, Ortega E, Piñero A, Correro F, Brieva JA, Nieto A, Koeleman BP, Martín J
  Hum Immunol. 2005
  PubMed ID: 15784471
   
  
• Distinct tumour necrosis factor alpha, interferon gamma, interleukin 10, and cytotoxic T cell antigen 4 gene polymorphisms in disease occurrence and end stage renal disease in Wegener's granulomatosis.
  Spriewald BM, Witzke O, Wassmuth R, Wenzel RR, Arnold ML, Philipp T, Kalden JR
  Ann Rheum Dis. 2005
  PubMed ID: 15708894
   
  
• Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4.
  Probst HC, McCoy K, Okazaki T, Honjo T, van den Broek M
  Nat Immunol. 2005
  PubMed ID: 15685176
   
  
• Association of the A/G polymorphism at position 49 in exon 1 of CTLA-4 with the susceptibility to unexplained recurrent spontaneous abortion in the Chinese population.
  Wang X, Lin Q, Ma Z, Hong Y, Zhao A, Di W, Lu P
  Am J Reprod Immunol. 2005
  PubMed ID: 15790344
   
  
• CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese.
  Fukazawa T, Kikuchi S, Miyagishi R, Niino M, Yabe I, Hamada T, Sasaki H
  J Neuroimmunol. 2005
  PubMed ID: 15652423
   
  
• CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases.
  Blomhoff A, Kemp EH, Gawkrodger DJ, Weetman AP, Husebye ES, Akselsen HE, Lie BA, Undlien DE
  Pigment Cell Res. 2005
  PubMed ID: 15649153
   
  
• CTLA-4 overexpression in CD19+/CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients.
  Kosmaczewska A, Ciszak L, Suwalska K, Wolowiec D, Frydecka I
  Leukemia. 2005
  PubMed ID: 15549146
   
  
• Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies.
  May KF, Roychowdhury S, Bhatt D, Kocak E, Bai XF, Liu JQ, Ferketich AK, Martin EW, Caligiuri MA, Zheng P, Liu Y
  Blood. 2005
  PubMed ID: 15486062
   
  
• Multiple negative feedbacks on CD152 expression in allograft tolerance.
  Tsai MK, Ho HN, Chien HF, Tzeng MC, Chen CH, Lee PH
  Transplantation. 2005
  PubMed ID: 15665765
   
  
• Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer.
  Demaria S, Kawashima N, Yang AM, Devitt ML, Babb JS, Allison JP, Formenti SC
  Clin Cancer Res. 2005
  PubMed ID: 15701862
   
  
• Expression of CD28 and CTLA4 on T cells in bone morrow of immune-mediated aplastic anemia mice.
  Liu Z, Sun H, Liu W, Luo X, He L, Xu H
  J Huazhong Univ Sci Technolog Med Sci. 2005
  PubMed ID: 16463658
   
  
• CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population.
  Weng YC, Wu MJ, Lin WS
  Ann Clin Lab Sci. 2005
  PubMed ID: 16081581
   
  
• Association of HLA-DR, -DQ genotype and CTLA-4 gene polymorphism with Graves' disease in Japanese children.
  Iwama S, Ikezaki A, Kikuoka N, Kim HS, Matsuoka H, Yanagawa T, Sato H, Hoshi M, Sakamaki T, Sugihara S
  Horm Res. 2005
  PubMed ID: 15640608
   
  
• Heterozygosity in CTLA-4 gene and severe preeclampsia.
  Samsami Dehaghani A, Doroudchi M, Kalantari T, Pezeshki AM, Ghaderi A
  Int J Gynaecol Obstet. 2005
  PubMed ID: 15617700
   
  
• CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization.
  van Wijk F, Hoeks S, Nierkens S, Koppelman SJ, van Kooten P, Boon L, Knippels LM, Pieters R
  J Immunol. 2005
  PubMed ID: 15611239
   
  
• CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance.
  Inobe M, Schwartz RH
  J Immunol. 2004
  PubMed ID: 15585846
   
  
• Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
  Li D, Gál I, Vermes C, Alegre ML, Chong AS, Chen L, Shao Q, Adarichev V, Xu X, Koreny T, Mikecz K, Finnegan A, Glant TT, Zhang J
  J Immunol. 2004
  PubMed ID: 15585834
   
  
• High-affinity small molecule inhibitors of T cell costimulation: compounds for immunotherapy.
  Huxley P, Sutton DH, Debnam P, Matthews IR, Brewer JE, Rose J, Trickett M, Williams DD, Andersen TB, Classon BJ
  Chem Biol. 2004
  PubMed ID: 15610849
   
  
• Gender-limited association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) polymorphism with cord blood IgE levels.
  Chang JC, Liu CA, Chuang H, Ou CY, Hsu TY, Huang EY, Yang KD
  Pediatr Allergy Immunol. 2004
  PubMed ID: 15610363
   
  
• Role of CTLA-4 in the activation of single- and double-positive thymocytes.
  Kwon H, Jun HS, Khil LY, Yoon JW
  J Immunol. 2004
  PubMed ID: 15557155
   
  
• Cytotoxic T-lymphocyte antigen-4-CT60 polymorphism in rheumatoid arthritis.
  Orozco G, Torres B, Núñez-Roldán A, González-Escribano MF, Martín J
  Tissue Antigens. 2004
  PubMed ID: 15546339
   
  
• Analysis of 6 genetic loci for disease susceptibility in psoriatic arthritis.
  Alenius GM, Friberg C, Nilsson S, Wahlström J, Dahlqvist SR, Samuelsson L
  J Rheumatol. 2004
  PubMed ID: 15517637
   
  
• Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
  Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, Chuang E, Alegre ML
  J Immunol. 2004
  PubMed ID: 15494488
   
  
• Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
  Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA
  Eur J Immunol. 2004
  PubMed ID: 15468055
   
  
• Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population.
  Fan LY, Tu XQ, Cheng QB, Zhu Y, Feltens R, Pfeiffer T, Zhong RQ
  World J Gastroenterol. 2004
  PubMed ID: 15378793
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• [Association of CTLA-4 promoter -1722 polymorphism with systemic lupus erythematosus in Chinese]
  Xu AP, Yin PD, Su XY
  Di Yi Jun Yi Da Xue Xue Bao. 2004
  PubMed ID: 15485777
   
  
• [Study on the relationship of CTLA-4 -318, +49 polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in a Chinese population]
  Fan LY, Zhu Y, Zhong RQ, Tu XQ, Chen QB, Zhou L, Liu HY, Kong XT
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004
  PubMed ID: 15476165
   
  
• Cytotoxic T-lymphocyte antigen 4 gene and recovery from hepatitis B virus infection.
  Thio CL, Mosbruger TL, Kaslow RA, Karp CL, Strathdee SA, Vlahov D, O'Brien SJ, Astemborski J, Thomas DL
  J Virol. 2004
  PubMed ID: 15452244
   
  
• No evidence of association of CTLA4 polymorphisms with Addison's disease.
  Pérez de Nanclares G, Martín-Pagola A, Ramón Bilbao J, Vázquez F, Castaño L
  Autoimmunity. 2004
  PubMed ID: 15621571
   
  
• CTLA-4 (CD152) gene polymorphism at position 49 in exon 1 in Graves' disease in a Polish population of the Lower Silesian region.
  Frydecka I, Daroszewski J, Suwalska K, Zołedziowska M, Tutak A, Słowik M, Potoczek S, Dobosz T
  Arch Immunol Ther Exp (Warsz). 2004
  PubMed ID: 15507878
   
  
• B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
  Pentcheva-Hoang T, Egen JG, Wojnoonski K, Allison JP
  Immunity. 2004
  PubMed ID: 15357951
   
  
• Analysis of immune regulatory genes in familial and sporadic Graves' disease.
  Ban Y, Concepcion ES, Villanueva R, Greenberg DA, Davies TF, Tomer Y
  J Clin Endocrinol Metab. 2004
  PubMed ID: 15356063
   
  
• CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients.
  van Belzen MJ, Mulder CJ, Zhernakova A, Pearson PL, Houwen RH, Wijmenga C
  Eur J Hum Genet. 2004
  PubMed ID: 15199380
   
  
• B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8- T cells in the thymus.
  Zheng X, Gao JX, Chang X, Wang Y, Liu Y, Wen J, Zhang H, Zhang J, Liu Y, Zheng P
  J Immunol. 2004
  PubMed ID: 15294937
   
  
• An analysis of CTLA-4 and proinflammatory cytokine genes in Wegener's granulomatosis.
  Zhou Y, Huang D, Paris PL, Sauter CS, Prock KA, Hoffman GS
  Arthritis Rheum. 2004
  PubMed ID: 15334480
   
  
• CTLA-4 polymorphisms in allergy and asthma and the TH1/ TH2 paradigm.
  Munthe-Kaas MC, Carlsen KH, Helms PJ, Gerritsen J, Whyte M, Feijen M, Skinningsrud B, Main M, Kwong GN, Lie BA, Lødrup Carlsen KC, Undlien DE
  J Allergy Clin Immunol. 2004
  PubMed ID: 15316504
   
  
• Overexpression of a mutant CTLA4 inhibits T-cell activation and homeostasis-driven expansion.
  Mao Y, Brigham D, Chen D
  Exp Hematol. 2004
  PubMed ID: 15308325
   
  
• Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus.
  Barreto M, Santos E, Ferreira R, Fesel C, Fontes MF, Pereira C, Martins B, Andreia R, Viana JF, Crespo F, Vasconcelos C, Ferreira C, Vicente AM
  Eur J Hum Genet. 2004
  PubMed ID: 15138458
   
  
• Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus.
  Torres B, Aguilar F, Franco E, Sánchez E, Sánchez-Román J, Jiménez Alonso J, Núñez-Roldán A, Martín J, González-Escribano MF
  Arthritis Rheum. 2004
  PubMed ID: 15248219
   
  
• Cytotoxic T lymphocyte antigen-4 gene in breast cancer.
  Ghaderi A, Yeganeh F, Kalantari T, Talei AR, Pezeshki AM, Doroudchi M, Dehaghani AS
  Breast Cancer Res Treat. 2004
  PubMed ID: 15218356
   
  
• Cytotoxic T-lymphocyte antigen-4 A49G polymorphism is associated with susceptibility to and severity of alcoholic liver disease in Italian patients.
  Valenti L, De Feo T, Fracanzani AL, Fatta E, Salvagnini M, Aricò S, Rossi G, Fiorelli G, Fargion S
  Alcohol Alcohol. 2004
  PubMed ID: 15208156
   
  
• Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism.
  Bilińska M, Frydecka I, Noga L, Dobosz T, Zołedziewska M, Suwalska K, Tutak A, Pokryszko-Dragan A
  Acta Neurol Scand. 2004
  PubMed ID: 15180809
   
  
• MHC class II-independent and -dependent T cell expansion and B cell hyperactivity in vivo in mice deficient in CD152 (CTLA-4).
  Stohl W, Xu D, Kim KS, David CS, Allison JP
  Int Immunol. 2004
  PubMed ID: 15136557
   
  
• CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.
  Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD
  J Immunol. 2004
  PubMed ID: 15187122
   
  
• CTLA-4 gene polymorphism and its association with Graves' disease in the Lebanese population.
  Nakkash-Chmaisse H, Makki RF, Abdelhamid E, Fakhoury H, Salti NN, Salti I
  Eur J Immunogenet. 2004
  PubMed ID: 15182328
   
  
• Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand.
  Madrenas J, Chau LA, Teft WA, Wu PW, Jussif J, Kasaian M, Carreno BM, Ling V
  J Immunol. 2004
  PubMed ID: 15128776
   
  
• Involvement of CTLA-4 in T-cell anergy induced by staphylococcal enterotoxin A in vitro.
  Xu GL, Zhu XH, Guo B, Wu YZ
  Mol Immunol. 2004
  PubMed ID: 15140570
   
  
• Cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphism and susceptibility to non-Hodgkin's lymphoma.
  Monne M, Piras G, Palmas A, Arru L, Murineddu M, Latte G, Noli A, Gabbas A
  Am J Hematol. 2004
  PubMed ID: 15114591
   
  
• CTLA-4 blockage increases resistance to infection with the intracellular protozoan Trypanosoma cruzi.
  Martins GA, Tadokoro CE, Silva RB, Silva JS, Rizzo LV
  J Immunol. 2004
  PubMed ID: 15067068
   
  
• Association of CTLA-4 gene polymorphism with oral submucous fibrosis in Taiwan.
  Shin YN, Liu CJ, Chang KW, Lee YJ, Liu HF
  J Oral Pathol Med. 2004
  PubMed ID: 15061706
   
  
• Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo.
  Yi LA, Hajialiasgar S, Chuang E
  Int Immunol. 2004
  PubMed ID: 15039384
   
  
• CTLA-4+CD8+ T cells that encounter B7-2+ iris pigment epithelial cells express their own B7-2 to achieve global suppression of T cell activation.
  Sugita S, Ng TF, Schwartzkopff J, Streilein JW
  J Immunol. 2004
  PubMed ID: 15034031
   
  
• CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.
  Pandiyan P, Gärtner D, Soezeri O, Radbruch A, Schulze-Osthoff K, Brunner-Weinzierl MC
  J Exp Med. 2004
  PubMed ID: 15007096
   
  
• [Association between the cytotoxic T lymphocyte antigen-4 gene microsatellite polymorphism and inflammatory bowel diseases in the Chinese]
  Jiang Y, Xia B
  Zhonghua Nei Ke Za Zhi. 2004
  PubMed ID: 15059373
   
  
• Structural and functional analysis of the costimulatory receptor programmed death-1.
  Zhang X, Schwartz JC, Guo X, Bhatia S, Cao E, Lorenz M, Cammer M, Chen L, Zhang ZY, Edidin MA, Nathenson SG, Almo SC
  Immunity. 2004
  PubMed ID: 15030777
   
  
• The role of B7 molecules in the cell contact-mediated suppression of T cell mitogenesis by immunosuppressive macrophages induced with mycobacterial infection.
  Shimizu T, Sano C, Tomioka H
  Clin Exp Immunol. 2004
  PubMed ID: 15008968
   
  
• Association of common T cell activation gene polymorphisms with multiple sclerosis in Australian patients.
  Teutsch SM, Booth DR, Bennetts BH, Heard RN, Stewart GJ
  J Neuroimmunol. 2004
  PubMed ID: 14975605
   
  
• Two different forms of human CTLA-4 proteins following peripheral T cell activation.
  Chun T, Choi HJ, Chung YH
  Immunol Lett. 2004
  PubMed ID: 15019292
   
  
• Schistosoma mansoni PIII antigen modulates in vitro granuloma formation by regulating CD28, CTLA-4, and CD86 expression in humans.
  Zouain CS, Falcão PL, Goes TS, Leite MF, Goes AM
  Immunol Lett. 2004
  PubMed ID: 15019278
   
  
• Complex genetic predisposition in adult and juvenile rheumatoid arthritis.
  Miterski B, Drynda S, Böschow G, Klein W, Oppermann J, Kekow J, Epplen JT
  BMC Genet. 2004
  PubMed ID: 15018649
   
  
• No evidence for an association of the CTLA4 gene with bipolar I disorder.
  Jun TY, Lee KU, Pae CU, Kweon YS, Chae JH, Bahk WM, Kim KS, Lew TY, Han H
  Psychiatry Clin Neurosci. 2004
  PubMed ID: 14678452
   
  
• The cytotoxic potential of regulatory T cells: what has been learned from gene knockout model systems?
  Marks L, Levy RB
  Transplantation. 2004
  PubMed ID: 14726764
   
  
• The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: a crosscheck hypothesis.
  Tsai MK, Ho HN, Chien HF, Ou-Yang P, Lee CJ, Lee PH
  Transplantation. 2004
  PubMed ID: 14724434
   
  
• CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.
  Parks CG, Hudson LL, Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP
  Lupus. 2004
  PubMed ID: 15540511
   
  
• Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese.
  Furugaki K, Shirasawa S, Ishikawa N, Ito K, Ito K, Kubota S, Kuma K, Tamai H, Akamizu T, Hiratani H, Tanaka M, Sasazuki T
  J Hum Genet. 2004
  PubMed ID: 14986169
   
  
• A CTLA-4 polymorphism associated with susceptibility to systemic lupus erythematosus.
  Fernandez-Blanco L, Perez-Pampin E, Gomez-Reino JJ, Gonzalez A
  Arthritis Rheum. 2004
  PubMed ID: 14730632
   
  
• Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases.
  Yang KD, Liu CA, Chang JC, Chuang H, Ou CY, Hsu TY, Wang CL
  Clin Exp Allergy. 2004
  PubMed ID: 14720259
   
  
• Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal.
  Wang PW, Liu RT, Juo SH, Wang ST, Hu YH, Hsieh CJ, Chen MH, Chen IY, Wu CL
  J Clin Endocrinol Metab. 2004
  PubMed ID: 14715845
   
  
• Ethnic differences in cytotoxic T lymphocyte associated antigen 4 genotype associations with systemic sclerosis.
  Hudson LL, Silver RM, Pandey JP
  J Rheumatol. 2004
  PubMed ID: 14705224
   
  
• Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population.
  Terauchi M, Yanagawa T, Ishikawa N, Ito K, Fukazawa T, Maruyama H, Saruta T
  J Endocrinol Invest. 2003
  PubMed ID: 15055474
   
  
• CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves' disease.
  Takara M, Kouki T, DeGroot LJ
  Thyroid. 2003
  PubMed ID: 14751028
   
  
• Recipient ctla-4 +49 G/G genotype is associated with reduced incidence of acute rejection after liver transplantation.
  de Reuver P, Pravica V, Hop W, Boor P, Metselaar HJ, Hutchinson IV, Tilanus HW, Kwekkeboom J
  Am J Transplant. 2003
  PubMed ID: 14629291
   
  
• Promoter polymorphism of IL-10 and severity of multiple sclerosis.
  Luomala M, Lehtimäki T, Huhtala H, Ukkonen M, Koivula T, Hurme M, Elovaara I
  Acta Neurol Scand. 2003
  PubMed ID: 14616291
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• CD4+CD25+ regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4.
  Liu H, Hu B, Xu D, Liew FY
  J Immunol. 2003
  PubMed ID: 14607897
   
  
• Cytotoxic T-lymphocyte antigen-4 (CTLA-4) exon 1 polymorphism affects lymphocyte profiles in bronchoalveolar lavage of patients with sarcoidosis.
  Handa T, Nagai S, Ito I, Shigematsu M, Hamada K, Kitaichi M, Izumi T, Mishima M
  Sarcoidosis Vasc Diffuse Lung Dis. 2003
  PubMed ID: 14620161
   
  
• CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus.
  Aguilar F, Torres B, Sánchez-Román J, Núñez-Roldán A, González-Escribano MF
  Hum Immunol. 2003
  PubMed ID: 14522090
   
  
• Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes.
  Maszyna F, Hoff H, Kunkel D, Radbruch A, Brunner-Weinzierl MC
  J Immunol. 2003
  PubMed ID: 14500641
   
  
• Association of CTLA4 gene A-G polymorphism with rheumatoid arthritis in Chinese.
  Lee CS, Lee YJ, Liu HF, Su CH, Chang SC, Wang BR, Chen TL, Liu TL
  Clin Rheumatol. 2003
  PubMed ID: 14505215
   
  
• CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease.
  Deurloo DT, van Berkel MA, van Esch BC, Hofhuis F, Nijkamp FP, Oosterwegel MA, van Oosterhout AJ
  Clin Exp Allergy. 2003
  PubMed ID: 12956753
   
  
• Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis.
  Bittencourt PL, Palácios SA, Farias AQ, Abrantes-Lemos CP, Cançado EL, Carrilho FJ, Laudanna AA, Kalil J, Goldberg AC
  J Gastroenterol Hepatol. 2003
  PubMed ID: 12911663
   
  
• Exon-1 polymorphism of ctla-4 gene in Iranian patients with Graves' disease.
  Kalantari T, Mostafavi H, Pezeshki AM, Farjadian S, Doroudchi M, Yeganeh F, Ghaderi A
  Autoimmunity. 2003
  PubMed ID: 14567561
   
  
• CTLA-4 and its role in autoimmune thyroid disease.
  Chistiakov DA, Turakulov RI
  J Mol Endocrinol. 2003
  PubMed ID: 12914522
   
  
• Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.
  Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, Restifo NP, Haworth LR, Seipp CA, Freezer LJ, Morton KE, Mavroukakis SA, Duray PH, Steinberg SM, Allison JP, Davis TA, Rosenberg SA
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12826605
   
  
• Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.
  Sugita S, Streilein JW
  J Exp Med. 2003
  PubMed ID: 12835481
   
  
• CTLA-4 dimorphisms in Japanese patients with systemic lupus erythematosus.
  Takeuchi F, Kawasugi K, Nabeta H, Mori M, Tanimoto K
  Clin Exp Rheumatol. 2003
  PubMed ID: 12942714
   
  
• Cytotoxic T lymphocyte antigen-4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil.
  Bittencourt PL, Palácios SA, Cançado EL, Porta G, Carrilho FJ, Laudanna AA, Kalil J, Goldberg AC
  Am J Gastroenterol. 2003
  PubMed ID: 12873588
   
  
• CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis.
  van Veen T, Crusius JB, van Winsen L, Xia B, Barkhof F, Salvador Peña A, Polman CH, Uitdehaag BM
  J Neuroimmunol. 2003
  PubMed ID: 12864988
   
  
• Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis.
  Tsuchiya N, Kobayashi S, Kawasaki A, Kyogoku C, Arimura Y, Yoshida M, Tokunaga K, Hashimoto H
  J Rheumatol. 2003
  PubMed ID: 12858454
   
  
• Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients.
  Alizadeh M, Babron MC, Birebent B, Matsuda F, Quelvennec E, Liblau R, Cournu-Rebeix I, Momigliano-Richiardi P, Sequeiros J, Yaouanq J, Genin E, Vasilescu A, Bougerie H, Trojano M, Martins Silva B, Maciel P, Clerget-Darpoux F, Clanet M, Edan G, Fontaine B, Semana G
  Ann Neurol. 2003
  PubMed ID: 12838528
   
  
• BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
  Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM
  Nat Immunol. 2003
  PubMed ID: 12796776
   
  
• CTLA-4. FasL induces alloantigen-specific hyporesponsiveness.
  Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML
  J Immunol. 2003
  PubMed ID: 12794109
   
  
• Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus.
  Liu MF, Wang CR, Chen PC, Fung LL
  Scand J Immunol. 2003
  PubMed ID: 12791095
   
  
• CTLA4 gene and Graves' disease: association of Graves' disease with the CTLA4 exon 1 and intron 1 polymorphisms, but not with the promoter polymorphism.
  Vaidya B, Oakes EJ, Imrie H, Dickinson AJ, Perros P, Kendall-Taylor P, Pearce SH
  Clin Endocrinol (Oxf). 2003
  PubMed ID: 12780750
   
  
• A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
  Buhlmann JE, Elkin SK, Sharpe AH
  J Immunol. 2003
  PubMed ID: 12759417
   
  
• Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen.
  Shirasugi N, Akiyama Y, Aramaki O, Shibutani S, Matsumoto K, Bashuda H, Yagita H, Okumura K, Ikeda Y, Niimi M
  Transplantation. 2003
  PubMed ID: 12777848
   
  
• A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
  Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, Takahashi T, Miyoshi K, Nakamura K, Izumi T, Matsushita Y, Furukawa H, Haruyama H, Koga T
  Clin Pharmacol Ther. 2003
  PubMed ID: 12732844
   
  
• Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis.
  Campanelli AP, Martins GA, Souto JT, Pereira MS, Livonesi MC, Martinez R, Silva JS
  J Infect Dis. 2003
  PubMed ID: 12717632
   
  
• c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity.
  Goto E, Ishido S, Sato Y, Ohgimoto S, Ohgimoto K, Nagano-Fujii M, Hotta H
  J Biol Chem. 2003
  PubMed ID: 12582153
   
  
• Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection.
  Yee LJ, Perez KA, Tang J, van Leeuwen DJ, Kaslow RA
  J Infect Dis. 2003
  PubMed ID: 12696006
   
  
• An essential role for Scurfin in CD4+CD25+ T regulatory cells.
  Khattri R, Cox T, Yasayko SA, Ramsdell F
  Nat Immunol. 2003
  PubMed ID: 12612581
   
  
• Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling.
  Zhang X, Schwartz JC, Almo SC, Nathenson SG
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12606712
   
  
• CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation.
  Ubaldi V, Gatta L, Pace L, Doria G, Pioli C
  Clin Dev Immunol. 2003
  PubMed ID: 14575153
   
  
• Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.
  Butterfield RJ, Roper RJ, Rhein DM, Melvold RW, Haynes L, Ma RZ, Doerge RW, Teuscher C
  Genetics. 2003
  PubMed ID: 12663542
   
  
• CTLA-4 in filarial infections: implications for a role in diminished T cell reactivity.
  Steel C, Nutman TB
  J Immunol. 2003
  PubMed ID: 12574361
   
  
• CTLA-4 +49 A/G dimorphism in Italian patients with celiac disease.
  Mora B, Bonamico M, Indovina P, Megiorni F, Ferri M, Carbone MC, Cipolletta E, Mazzilli MC
  Hum Immunol. 2003
  PubMed ID: 12559633
   
  
• CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders.
  Pavkovic M, Georgievski B, Cevreska L, Spiroski M, Efremov DG
  Am J Hematol. 2003
  PubMed ID: 12555221
   
  
• Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease.
  Vidali M, Stewart SF, Rolla R, Daly AK, Chen Y, Mottaran E, Jones DE, Leathart JB, Day CP, Albano E
  Hepatology. 2003
  PubMed ID: 12540792
   
  
• CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
  Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA
  Nat Immunol. 2003
  PubMed ID: 12524538
   
  
• Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.
  Chikuma S, Imboden JB, Bluestone JA
  J Exp Med. 2003
  PubMed ID: 12515820
   
  
• Population frequencies of single nucleotide polymorphisms (SNPs) in immuno-modulatory genes.
  Martin AM, Athanasiadis G, Greshock JD, Fisher J, Lux MP, Calzone K, Rebbeck TR, Weber BL
  Hum Hered. 2003
  PubMed ID: 14566095
   
  
• Lack of association between an exon 1 CTLA-4 gene polymorphism A(49)G and multiple sclerosis in a Polish population of the Lower Silesia region.
  Boćko D, Bilińska M, Dobosz T, Zołedziewska M, Suwalska K, Tutak A, Gruszka E, Frydecka I
  Arch Immunol Ther Exp (Warsz). 2003
  PubMed ID: 12894875
   
  
• Inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity modulates surface expression of CTLA-4 in stress-induced abortions.
  Rüter J, Demuth HU, Arck PC, Hoffmann T, Klapp BF, Hildebrandt M
  Adv Exp Med Biol. 2003
  PubMed ID: 12675235
   
  
• Anti-CD28 has a potent adjuvant effect on the antibody response to soluble antigens mediated through CTLA-4 by-pass.
  Carlring J, Barr TA, Buckle AM, Heath AW
  Eur J Immunol. 2003
  PubMed ID: 12594842
   
  
• Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations.
  Bednarczuk T, Hiromatsu Y, Fukutani T, Jazdzewski K, Miskiewicz P, Osikowska M, Nauman J
  Eur J Endocrinol. 2003
  PubMed ID: 12534352
   
  
• Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor.
  Yin L, Schneider H, Rudd CE
  J Leukoc Biol. 2003
  PubMed ID: 12525576
   
  
• CTLA4 is associated with susceptibility to multiple sclerosis.
  Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray CT, de Andrade M, Hafler DA, Weinshenker BG
  J Neuroimmunol. 2003
  PubMed ID: 12507781
   
  
• Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4.
  Walker LS, Wiggett HE, Gaspal FM, Raykundalia CR, Goodall MD, Toellner KM, Lane PJ
  J Immunol. 2003
  PubMed ID: 12496387
   
  
• CTLA-4 is not restricted to the lymphoid cell lineage and can function as a target molecule for apoptosis induction of leukemic cells.
  Pistillo MP, Tazzari PL, Palmisano GL, Pierri I, Bolognesi A, Ferlito F, Capanni P, Polito L, Ratta M, Pileri S, Piccioli M, Basso G, Rissotto L, Conte R, Gobbi M, Stirpe F, Ferrara GB
  Blood. 2003
  PubMed ID: 12393538
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Initial sequencing and comparative analysis of the mouse genome.
  Mouse Genome Sequencing Consortium, Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigó R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES
  Nature. 2002
  PubMed ID: 12466850
   
  
• Cyclic adenosine 5'-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytes.
  Vendetti S, Riccomi A, Sacchi A, Gatta L, Pioli C, De Magistris MT
  J Immunol. 2002
  PubMed ID: 12444128
   
  
• A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele.
  Anjos S, Nguyen A, Ounissi-Benkalha H, Tessier MC, Polychronakos C
  J Biol Chem. 2002
  PubMed ID: 12244107
   
  
• Association of CTLA-4 with systemic sclerosis in Japanese patients.
  Takeuchi F, Kawasugi K, Nabeta H, Mori M, Tanimoto K
  Clin Exp Rheumatol. 2002
  PubMed ID: 12508774
   
  
• CTLA4 gene polymorphisms in Dutch and Chinese patients with inflammatory bowel disease.
  Xia B, Crusius JB, Wu J, Zwiers A, van Bodegraven AA, Peña AS
  Scand J Gastroenterol. 2002
  PubMed ID: 12465728
   
  
• Role of CD80, CD86, and CTLA4 on mouse CD4(+) T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin.
  Mukherjee S, Maiti PK, Nandi D
  J Leukoc Biol. 2002
  PubMed ID: 12429713
   
  
• CTLA4 exon 1 dimorphism is associated with primary progressive multiple sclerosis.
  Mäurer M, Ponath A, Kruse N, Rieckmann P
  J Neuroimmunol. 2002
  PubMed ID: 12458055
   
  
• CTLA4 dimorphisms and the multiple sclerosis phenotype.
  Masterman T, Ligers A, Zhang Z, Hellgren D, Salter H, Anvret M, Hillert J
  J Neuroimmunol. 2002
  PubMed ID: 12458054
   
  
• CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region.
  Hudson LL, Rocca K, Song YW, Pandey JP
  Hum Genet. 2002
  PubMed ID: 12384790
   
  
• CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance.
  Fowler S, Powrie F
  Eur J Immunol. 2002
  PubMed ID: 12355454
   
  
• Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.
  Manzotti CN, Tipping H, Perry LC, Mead KI, Blair PJ, Zheng Y, Sansom DM
  Eur J Immunol. 2002
  PubMed ID: 12355442
   
  
• Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size.
  Sho M, Yamada A, Najafian N, Salama AD, Harada H, Sandner SE, Sanchez-Fueyo A, Zheng XX, Strom TB, Sayegh MH
  J Immunol. 2002
  PubMed ID: 12244168
   
  
• Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.
  Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE
  J Immunol. 2002
  PubMed ID: 12244135
   
  
• B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice.
  Akiyama Y, Shirasugi N, Uchida N, Matsumoto K, Kitajima M, Bashuda H, Yagita H, Okumura K, Aramaki O, Niimi M
  Transplantation. 2002
  PubMed ID: 12352894
   
  
• Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
  Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12195015
   
  
• Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence.
  Wang XB, Kakoulidou M, Giscombe R, Qiu Q, Huang D, Pirskanen R, Lefvert AK
  J Neuroimmunol. 2002
  PubMed ID: 12225905
   
  
• Murine malaria is exacerbated by CTLA-4 blockade.
  Jacobs T, Graefe SE, Niknafs S, Gaworski I, Fleischer B
  J Immunol. 2002
  PubMed ID: 12193697
   
  
• Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4.
  Tivol EA, Gorski J
  J Immunol. 2002
  PubMed ID: 12165509
   
  
• Cytotoxic T-lymphocyte antigen-4 gene polymorphisms and human T-cell lymphotrophic virus-1 infection: their associations with Hashimoto's thyroiditis in Japanese patients.
  Tomoyose T, Komiya I, Takara M, Yabiku K, Kinjo Y, Shimajiri Y, Yogi H, Kouki T, Masuda M, Takasu N
  Thyroid. 2002
  PubMed ID: 12225635
   
  
• Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
  Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML
  J Immunol. 2002
  PubMed ID: 12097362
   
  
• CTLA-4 upregulation during aging.
  Leng Q, Bentwich Z, Borkow G
  Mech Ageing Dev. 2002
  PubMed ID: 12297345
   
  
• [Polymorphism A/G in position +49 of CTLA4 exon 1 in multiple sclerosis in Russians]
  Andreevskiĭ TV, Sudomoina MA, Gusev EI, Boĭko AN, Alekseenkov AD, Favorova OO
  Mol Biol (Mosk). 2002
  PubMed ID: 12173468
   
  
• Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.
  Miller RE, Fayen JD, Mohammad SF, Stein K, Kadereit S, Woods KD, Sramkoski RM, Jacobberger JW, Templeton D, Shurin SB, Laughlin MJ
  Exp Hematol. 2002
  PubMed ID: 12135671
   
  
• Association of asthma severity and bronchial hyperresponsiveness with a polymorphism in the cytotoxic T-lymphocyte antigen-4 gene.
  Lee SY, Lee YH, Shin C, Shim JJ, Kang KH, Yoo SH, In KH
  Chest. 2002
  PubMed ID: 12114354
   
  
• The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor.
  Chambers CA, Kang J, Wu Y, Held W, Raulet DH, Allison JP
  Blood. 2002
  PubMed ID: 12036882
   
  
• Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules.
  Miranda LR, Schaefer BC, Kupfer A, Hu Z, Franzusoff A
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12060749
   
  
• Expression, refolding, purification, molecular characterization, crystallization, and preliminary X-ray analysis of the receptor binding domain of human B7-2.
  Zhang X, Schwartz JC, Almo SC, Nathenson SG
  Protein Expr Purif. 2002
  PubMed ID: 12071705
   
  
• A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein.
  Wang XB, Zhao X, Giscombe R, Lefvert AK
  Genes Immun. 2002
  PubMed ID: 12058260
   
  
• Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene.
  Kinjo Y, Takasu N, Komiya I, Tomoyose T, Takara M, Kouki T, Shimajiri Y, Yabiku K, Yoshimura H
  J Clin Endocrinol Metab. 2002
  PubMed ID: 12050220
   
  
• Long-term therapy with recombinant human erythropoietin decreases percentage of CD152(+) lymphocytes in primary glomerulonephritis haemodialysis patients.
  Trzonkowski P, Myśliwska J, Debska-Slizień A, Bryl E, Rachoń D, Myśliwski A, Rutkowski B
  Nephrol Dial Transplant. 2002
  PubMed ID: 12032199
   
  
• Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation.
  Darlington PJ, Baroja ML, Chau TA, Siu E, Ling V, Carreno BM, Madrenas J
  J Exp Med. 2002
  PubMed ID: 12021313
   
  
• Polymorphism of CTLA-4 gene at position 49 of exon 1 may be associated with schizophrenia in the Korean population.
  Jun TY, Pae CU, Chae JH, Bahk WM, Kim KS, Han H
  Psychiatry Res. 2002
  PubMed ID: 12007590
   
  
• Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A.
  Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK
  J Immunol. 2002
  PubMed ID: 11994459
   
  
• The influence of the exon 1 polymorphism of the cytotoxic T lymphocyte antigen 4 gene on thyroid antibody production in patients with newly diagnosed Graves' disease.
  Zaletel K, Krhin B, Gaberscek S, Pirnat E, Hojker S
  Thyroid. 2002
  PubMed ID: 12097196
   
  
• CTLA-4 gene A-G polymorphism and childhood Graves' disease.
  Yung E, Cheng PS, Fok TF, Wong GW
  Clin Endocrinol (Oxf). 2002
  PubMed ID: 12030917
   
  
• Coding sequence 1 and promoter single nucleotide polymorphisms in the CTLA-4 gene in Wegener's granulomatosis.
  Giscombe R, Wang X, Huang D, Lefvert AK
  J Rheumatol. 2002
  PubMed ID: 12022356
   
  
• Structural mechanisms of costimulation.
  Schwartz JC, Zhang X, Nathenson SG, Almo SC
  Nat Immunol. 2002
  PubMed ID: 11976720
   
  
• Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.
  Hsu HC, Mountz JD, Williams RW, Shelton BJ, Yang PA, Matsuki Y, Xu X, Dodd CH, Li L, Geiger H, Zhang HG, Van Zant G
  Mech Ageing Dev. 2002
  PubMed ID: 12044964
   
  
• B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo.
  Bai XF, Liu J, May KF, Guo Y, Zheng P, Liu Y
  Blood. 2002
  PubMed ID: 11929778
   
  
• The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.
  Eagar TN, Karandikar NJ, Bluestone JA, Miller SD
  Eur J Immunol. 2002
  PubMed ID: 11920563
   
  
• Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia.
  LaBelle JL, Hanke CA, Blazar BR, Truitt RL
  Blood. 2002
  PubMed ID: 11877291
   
  
• Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice.
  Hurwitz AA, Sullivan TJ, Sobel RA, Allison JP
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 11867713
   
  
• Relation of three polymorphisms of the CTLA-4 gene in patients with Graves' disease.
  Kouki T, Gardine CA, Yanagawa T, Degroot LJ
  J Endocrinol Invest. 2002
  PubMed ID: 11936461
   
  
• CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4.
  Xu Y, Graves PN, Tomer Y, Davies TF
  Cell Immunol. 2002
  PubMed ID: 12202150
   
  
• CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis.
  Wang XB, Kakoulidou M, Qiu Q, Giscombe R, Huang D, Pirskanen R, Lefvert AK
  Genes Immun. 2002
  PubMed ID: 11857062
   
  
• CTLA-4 regulates cell cycle progression during a primary immune response.
  Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH
  Eur J Immunol. 2002
  PubMed ID: 11807776
   
  
• No association of polymorphisms of the CTLA-4 exon 1(+49) and promoter(-318) genes with rheumatoid arthritis in the Korean population.
  Lee YH, Choi SJ, Ji JD, Song GG
  Scand J Rheumatol. 2002
  PubMed ID: 12455815
   
  
• Association of the CTLA4 3' untranslated region polymorphism with the susceptibility to rheumatoid arthritis.
  Rodríguez MR, Núñez-Roldán A, Aguilar F, Valenzuela A, García A, González-Escribano MF
  Hum Immunol. 2002
  PubMed ID: 11916172
   
  
• Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom.
  Nithiyananthan R, Heward JM, Allahabadia A, Franklyn JA, Gough SC
  Thyroid. 2002
  PubMed ID: 11842815
   
  
• CTLA-4/CD28 gene region is associated with genetic susceptibility to coeliac disease in UK families.
  King AL, Moodie SJ, Fraser JS, Curtis D, Reid E, Dearlove AM, Ellis HJ, Ciclitira PJ
  J Med Genet. 2002
  PubMed ID: 11826026
   
  
• Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells.
  Saverino D, Merlo A, Bruno S, Pistoia V, Grossi CE, Ciccone E
  J Immunol. 2002
  PubMed ID: 11751964
   
  
• HLA-DQB1 CAR1/CAR2, TNFa IR2/IR4 and CTLA-4 polymorphisms in Tunisian patients with rheumatoid arthritis and Sjögren's syndrome.
  Hadj Kacem H, Kaddour N, Adyel FZ, Bahloul Z, Ayadi H
  Rheumatology (Oxford). 2001
  PubMed ID: 11752507
   
  
• Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
  Ling V, Wu PW, Finnerty HF, Agostino MJ, Graham JR, Chen S, Jussiff JM, Fisk GJ, Miller CP, Collins M
  Genomics. 2001
  PubMed ID: 11735222
   
  
• CTLA-4 gene polymorphisms in Tunisian patients with Graves' disease.
  Hadj Kacem H, Bellassoued M, Bougacha-Elleuch N, Abid M, Ayadi H
  Clin Immunol. 2001
  PubMed ID: 11726229
   
  
• A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
  Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH
  Proc Natl Acad Sci U S A. 2001
  PubMed ID: 11707574
   
  
• CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.
  Frauwirth KA, Alegre ML, Thompson CB
  J Immunol. 2001
  PubMed ID: 11673499
   
  
• Study of the interaction of the medium chain mu 2 subunit of the clathrin-associated adapter protein complex 2 with cytotoxic T-lymphocyte antigen 4 and CD28.
  Follows ER, McPheat JC, Minshull C, Moore NC, Pauptit RA, Rowsell S, Stacey CL, Stanway JJ, Taylor IW, Abbott WM
  Biochem J. 2001
  PubMed ID: 11583591
   
  
• Polymorphism of CTLA-4 gene for major depression in the Korean population.
  Jun TY, Pae CU, Chae JH, Bahk WM, Kim KS
  Psychiatry Clin Neurosci. 2001
  PubMed ID: 11555351
   
  
• MHC class II region, CTLA4 gene, and ophthalmopathy in patients with Graves' disease.
  Allahabadia A, Heward JM, Nithiyananthan R, Gibson SM, Reuser TT, Dodson PM, Franklyn JA, Gough SC
  Lancet. 2001
  PubMed ID: 11583755
   
  
• B7 interactions with CD28 and CTLA-4 control tolerance or induction of mucosal inflammation in chronic experimental colitis.
  Liu Z, Geboes K, Hellings P, Maerten P, Heremans H, Vandenberghe P, Boon L, van Kooten P, Rutgeerts P, Ceuppens JL
  J Immunol. 2001
  PubMed ID: 11466409
   
  
• Polymorphism in codon 17 of the CTLA-4 gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians.
  Milicic A, Brown MA, Wordsworth BP
  Tissue Antigens. 2001
  PubMed ID: 11580858
   
  
• Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population.
  Ahmed S, Ihara K, Kanemitsu S, Nakashima H, Otsuka T, Tsuzaka K, Takeuchi T, Hara T
  Rheumatology (Oxford). 2001
  PubMed ID: 11426024
   
  
• B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.
  Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH
  J Clin Invest. 2001
  PubMed ID: 11285307
   
  
• Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.
  Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L
  Nature. 2001
  PubMed ID: 11279502
   
  
• Structural basis for co-stimulation by the human CTLA-4/B7-2 complex.
  Schwartz JC, Zhang X, Fedorov AA, Nathenson SG, Almo SC
  Nature. 2001
  PubMed ID: 11279501
   
  
• Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
  Gajewski TF, Fallarino F, Fields PE, Rivas F, Alegre ML
  J Immunol. 2001
  PubMed ID: 11238634
   
  
• CTLA4 in multiple sclerosis. Lack of genetic association in a European Caucasian population but evidence of interaction with HLA-DR2 among Shanghai Chinese.
  Rasmussen HB, Kelly MA, Francis DA, Clausen J
  J Neurol Sci. 2001
  PubMed ID: 11239948
   
  
• Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.
  Sullivan TJ, Letterio JJ, van Elsas A, Mamura M, van Amelsfort J, Sharpe S, Metzler B, Chambers CA, Allison JP
  Proc Natl Acad Sci U S A. 2001
  PubMed ID: 11226283
   
  
• Identification of an alternatively spliced variant of human CD86 mRNA.
  Magistrelli G, Caron G, Gauchat JF, Jeannin P, Bonnefoy JY, Delneste Y
  Biochem Biophys Res Commun. 2001
  PubMed ID: 11162656
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population.
  Petrone A, Giorgi G, Mesturino CA, Capizzi M, Cascino I, Nistico L, Osborn J, Di Mario U, Buzzetti R
  Thyroid. 2001
  PubMed ID: 11288988
   
  
• CTLA-4 regulates induction of anergy in vivo.
  Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH
  Immunity. 2001
  PubMed ID: 11239447
   
  
• Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3- and CTLA-4-deficient mice.
  Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ
  J Immunol. 2001
  PubMed ID: 11145642
   
  
• Polymorphsims of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies.
  Lee YH, Ji JD, Sohn J, Song GG
  Clin Rheumatol. 2001
  PubMed ID: 11771526
   
  
• CTLA-4 gene polymorphism in promoter and exon-1 regions in Chinese patients with systemic lupus erythematosus.
  Liu MF, Wang CR, Lin LC, Wu CR
  Lupus. 2001
  PubMed ID: 11678454
   
  
• Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus.
  Lee YH, Kim YR, Ji JD, Sohn J, Song GG
  Lupus. 2001
  PubMed ID: 11678447
   
  
• Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma.
  Zheng C, Huang D, Liu L, Björkholm M, Holm G, Yi Q, Sundblad A
  Br J Haematol. 2001
  PubMed ID: 11167807
   
  
• Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.
  Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM
  Development. 2001
  PubMed ID: 11092808
   
  
• CTLA-4 gene polymorphism in Japanese patients with rheumatoid arthritis.
  Yanagawa T, Gomi K, Nakao EI, Inada S
  J Rheumatol. 2000
  PubMed ID: 11128657
   
  
• CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease.
  Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ
  J Immunol. 2000
  PubMed ID: 11086105
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Structure of murine CTLA-4 and its role in modulating T cell responsiveness.
  Ostrov DA, Shi W, Schwartz JC, Almo SC, Nathenson SG
  Science. 2000
  PubMed ID: 11052947
   
  
• Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.
  Akamizu T, Sale MM, Rich SS, Hiratani H, Noh JY, Kanamoto N, Saijo M, Miyamoto Y, Saito Y, Nakao K, Bowden DW
  Thyroid. 2000
  PubMed ID: 11081251
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7.
  Vaughan AN, Malde P, Rogers NJ, Jackson IM, Lechler RI, Dorling A
  J Immunol. 2000
  PubMed ID: 10975832
   
  
• Soluble CD86 is a costimulatory molecule for human T lymphocytes.
  Jeannin P, Magistrelli G, Aubry JP, Caron G, Gauchat JF, Renno T, Herbault N, Goetsch L, Blaecke A, Dietrich PY, Bonnefoy JY, Delneste Y
  Immunity. 2000
  PubMed ID: 11021528
   
  
• Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene.
  Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, Kalachikov S, Cayanis E, Fischer SG, Barst RJ, Hodge SE, Knowles JA
  Am J Hum Genet. 2000
  PubMed ID: 10903931
   
  
• Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.
  Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S
  J Exp Med. 2000
  PubMed ID: 10899917
   
  
• Complex association analysis of graves disease using a set of polymorphic markers.
  Chistyakov DA, Savost'anov KV, Turakulov RI, Petunina NA, Trukhina LV, Kudinova AV, Balabolkin MI, Nosikov VV
  Mol Genet Metab. 2000
  PubMed ID: 10924276
   
  
• Cutting edge: a soluble form of CTLA-4 in patients with autoimmune thyroid disease.
  Oaks MK, Hallett KM
  J Immunol. 2000
  PubMed ID: 10799854
   
  
• Janus kinase 2 is associated with a box 1-like motif and phosphorylates a critical tyrosine residue in the cytoplasmic region of cytotoxic T lymphocyte associated molecule-4.
  Chikuma S, Murakami M, Tanaka K, Uede T
  J Cell Biochem. 2000
  PubMed ID: 10842319
   
  
• A native soluble form of CTLA-4.
  Oaks MK, Hallett KM, Penwell RT, Stauber EC, Warren SJ, Tector AJ
  Cell Immunol. 2000
  PubMed ID: 10831323
   
  
• A transgenic insertional inner ear mutation on mouse chromosome 1.
  Friedman RA, Adir Y, Crenshaw EB, Ryan AF, Rosenfeld MG
  Laryngoscope. 2000
  PubMed ID: 10763993
   
  
• Identification of intervals on chromosomes 1, 3, and 13 linked to the development of lupus in BXSB mice.
  Haywood ME, Hogarth MB, Slingsby JH, Rose SJ, Allen PJ, Thompson EM, Maibaum MA, Chandler P, Davies KA, Simpson E, Walport MJ, Morley BJ
  Arthritis Rheum. 2000
  PubMed ID: 10693874
   
  
• The Nef protein of HIV-1 associates with rafts and primes T cells for activation.
  Wang JK, Kiyokawa E, Verdin E, Trono D
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10618429
   
  
• Cloning and sequencing of dog cDNA encoding the T-cell costimulatory molecule (CTLA-4).
  Khatlani TS, Ohno K, Ma Z, Inokuma H, Onishi T
  Immunogenetics. 2000
  PubMed ID: 10663567
   
  
• Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy.
  Kwon ED, Foster BA, Hurwitz AA, Madias C, Allison JP, Greenberg NM, Burg MB
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 10611340
   
  
• Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
  Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM
  Nature. 1999
  PubMed ID: 10580503
   
  
• Cloning of feline cDNA encoding the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
  Ohno K, Fujiki M, Khatlani TS, Inokuma H, Onishi T
  J Vet Med Sci. 1999
  PubMed ID: 10593583
   
  
• A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells.
  Magistrelli G, Jeannin P, Herbault N, Benoit De Coignac A, Gauchat JF, Bonnefoy JY, Delneste Y
  Eur J Immunol. 1999
  PubMed ID: 10556814
   
  
• Expression of B7 molecules in recipient, not donor, mice determines the survival of cardiac allografts.
  Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH
  J Immunol. 1999
  PubMed ID: 10490971
   
  
• Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
  Ling V, Wu PW, Finnerty HF, Sharpe AH, Gray GS, Collins M
  Genomics. 1999
  PubMed ID: 10493833
   
  
• Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis.
  Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH
  J Exp Med. 1999
  PubMed ID: 10477557
   
  
• The role of CTLA-4 in regulating Th2 differentiation.
  Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH
  J Immunol. 1999
  PubMed ID: 10453003
   
  
• Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy.
  Vaidya B, Imrie H, Perros P, Dickinson J, McCarthy MI, Kendall-Taylor P, Pearce SH
  Lancet. 1999
  PubMed ID: 10475192
   
  
• Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.
  Chambers CA, Kuhns MS, Allison JP
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 10411922
   
  
• The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.
  Vaidya B, Imrie H, Perros P, Young ET, Kelly WF, Carr D, Large DM, Toft AD, McCarthy MI, Kendall-Taylor P, Pearce SH
  Hum Mol Genet. 1999
  PubMed ID: 10369864
   
  
• Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
  Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA
  J Immunol. 1999
  PubMed ID: 10229811
   
  
• CD28/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study.
  Holopainen P, Arvas M, Sistonen P, Mustalahti K, Collin P, Mäki M, Partanen J
  Tissue Antigens. 1999
  PubMed ID: 10372542
   
  
• Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
  Chuang E, Lee KM, Robbins MD, Duerr JM, Alegre ML, Hambor JE, Neveu MJ, Bluestone JA, Thompson CB
  J Immunol. 1999
  PubMed ID: 9973379
   
  
• B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
  Mandelbrot DA, McAdam AJ, Sharpe AH
  J Exp Med. 1999
  PubMed ID: 9892625
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis.
  Harbo HF, Celius EG, Vartdal F, Spurkland A
  Tissue Antigens. 1999
  PubMed ID: 10082437
   
  
• Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1.
  Lévy N, Boettger-Tong H, Dohmae K, Agoulnik AI, Ty TI, Nishimune Y, Bishop CE
  Genomics. 1998
  PubMed ID: 9828143
   
  
• A structural explanation for the recognition of tyrosine-based endocytotic signals.
  Owen DJ, Evans PR
  Science. 1998
  PubMed ID: 9812899
   
  
• Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
  Schneider H, Schwartzberg PL, Rudd CE
  Biochem Biophys Res Commun. 1998
  PubMed ID: 9813138
   
  
• Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells.
  Chambers CA, Sullivan TJ, Truong T, Allison JP
  Eur J Immunol. 1998
  PubMed ID: 9808182
   
  
• Expression and function of CTLA-4 in Th1 and Th2 cells.
  Alegre ML, Shiels H, Thompson CB, Gajewski TF
  J Immunol. 1998
  PubMed ID: 9759851
   
  
• Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).
  Miyatake S, Nakaseko C, Umemori H, Yamamoto T, Saito T
  Biochem Biophys Res Commun. 1998
  PubMed ID: 9712716
   
  
• Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
  Varfolomeev EE, Schuchmann M, Luria V, Chiannilkulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, Lapidot T, Soffer D, Sobe T, Avraham KB, Goncharov T, Holtmann H, Lonai P, Wallach D
  Immunity. 1998
  PubMed ID: 9729047
   
  
• Immune cell signaling aberrations in human lupus.
  Liossis SN, Sfikakis PP, Tsokos GC
  Immunol Res. 1998
  PubMed ID: 9724847
   
  
• CTLA-4 gene polymorphism is associated with predisposition to coeliac disease.
  Djilali-Saiah I, Schmitz J, Harfouch-Hammoud E, Mougenot JF, Bach JF, Caillat-Zucman S
  Gut. 1998
  PubMed ID: 10189842
   
  
• Requirements for B7-CD28 costimulation in mucosal IgA responses: paradoxes observed in CTLA4-H gamma 1 transgenic mice.
  Gärdby E, Lane P, Lycke NY
  J Immunol. 1998
  PubMed ID: 9647206
   
  
• B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.
  Zheng P, Wu Y, Guo Y, Lee C, Liu Y
  Proc Natl Acad Sci U S A. 1998
  PubMed ID: 9600957
   
  
• CTLA-4 is required for the induction of high dose oral tolerance.
  Samoilova EB, Horton JL, Zhang H, Khoury SJ, Weiner HL, Chen Y
  Int Immunol. 1998
  PubMed ID: 9620605
   
  
• Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.
  Bachmann MF, Waterhouse P, Speiser DE, McKall-Faienza K, Mak TW, Ohashi PS
  J Immunol. 1998
  PubMed ID: 9551960
   
  
• Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells.
  Chambers CA, Sullivan TJ, Allison JP
  Immunity. 1997
  PubMed ID: 9430233
   
  
• Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease.
  Donner H, Braun J, Seidl C, Rau H, Finke R, Ventz M, Walfish PG, Usadel KH, Badenhoop K
  J Clin Endocrinol Metab. 1997
  PubMed ID: 9398726
   
  
• Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
  Yang Z, Hanlon DW, Marszalek JR, Goldstein LS
  Genomics. 1997
  PubMed ID: 9339368
   
  
• Thymocyte development is normal in CTLA-4-deficient mice.
  Chambers CA, Cado D, Truong T, Allison JP
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9256476
   
  
• Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
  Zhang Y, Allison JP
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9256472
   
  
• Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice.
  Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW
  Eur J Immunol. 1997
  PubMed ID: 9295023
   
  
• Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer.
  Kwon ED, Hurwitz AA, Foster BA, Madias C, Feldhaus AL, Greenberg NM, Burg MB, Allison JP
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9223321
   
  
• Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28.
  Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS
  Nat Struct Biol. 1997
  PubMed ID: 9228944
   
  
• Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
  Chuang E, Alegre ML, Duckett CS, Noel PJ, Vander Heiden MG, Thompson CB
  J Immunol. 1997
  PubMed ID: 9200449
   
  
• CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice.
  Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH
  J Immunol. 1997
  PubMed ID: 9164923
   
  
• Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2.
  Shiratori T, Miyatake S, Ohno H, Nakaseko C, Isono K, Bonifacino JS, Saito T
  Immunity. 1997
  PubMed ID: 9175836
   
  
• Mapping of unconventional myosins in mouse and human.
  Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA
  Genomics. 1996
  PubMed ID: 8884266
   
  
• Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4.
  Marengère LE, Waterhouse P, Duncan GS, Mittrücker HW, Feng GS, Mak TW
  Science. 1996
  PubMed ID: 8638161
   
  
• A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.
  Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J
  J Biol Chem. 1996
  PubMed ID: 8626800
   
  
• Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.
  Truneh A, Reddy M, Ryan P, Lyn SD, Eichman C, Couez D, Hurle MR, Sekaly RP, Olive D, Sweet R
  Mol Immunol. 1996
  PubMed ID: 8649453
   
  
• Mouse chromosomal location of four Na/H exchanger isoform genes.
  Pathak BG, Shull GE, Jenkins NA, Copeland NG
  Genomics. 1996
  PubMed ID: 8824815
   
  
• Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996.
  Spur NK, Bashir R, Bushby K, Cox A, Cox S, Hilde Brandt F, Hill N, Kao FT, Krols L, Marzella R, Miller N, Nothwang HG, Rocchi M, Sarfarazi M, Stratakis CA, Wallgren-Petterson C, Naylor S
  Cytogenet Cell Genet. 1996
  PubMed ID: 8751373
   
  
• Nucleotide sequence of the ACI rat CTLA-4 molecule.
  Oaks MK, Penwell RT, Tector AJ
  Immunogenetics. 1996
  PubMed ID: 8550107
   
  
• Identification and chromosomal mapping of the mouse inositol polyphosphate 1-phosphatase gene.
  Okabe I, Nussbaum RL
  Genomics. 1995
  PubMed ID: 8586440
   
  
• Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4.
  Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW
  Science. 1995
  PubMed ID: 7481803
   
  
• Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.
  Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH
  Immunity. 1995
  PubMed ID: 7584144
   
  
• Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail.
  Leung HT, Bradshaw J, Cleaveland JS, Linsley PS
  J Biol Chem. 1995
  PubMed ID: 7559643
   
  
• Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28.
  Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS
  J Biol Chem. 1995
  PubMed ID: 7545666
   
  
• Distribution of the mammalian Stat gene family in mouse chromosomes.
  Copeland NG, Gilbert DJ, Schindler C, Zhong Z, Wen Z, Darnell JE, Mui AL, Miyajima A, Quelle FW, Ihle JN
  Genomics. 1995
  PubMed ID: 8530075
   
  
• Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
  Fargeas CA, Truneh A, Reddy M, Hurle M, Sweet R, Sékaly RP
  J Exp Med. 1995
  PubMed ID: 7544393
   
  
• Efficient high-resolution genetic mapping of mouse interspersed repetitive sequence PCR products, toward integrated genetic and physical mapping of the mouse genome.
  McCarthy L, Hunter K, Schalkwyk L, Riba L, Anson S, Mott R, Newell W, Bruley C, Bar I, Ramu E
  Proc Natl Acad Sci U S A. 1995
  PubMed ID: 7777502
   
  
• CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
  Schneider H, Prasad KV, Shoelson SE, Rudd CE
  J Exp Med. 1995
  PubMed ID: 7807015
   
  
• Cloning and sequencing of the rabbit gene encoding T-cell costimulatory molecules.
  Isono T, Seto A
  Immunogenetics. 1995
  PubMed ID: 7642234
   
  
• The murine dilute suppressor gene encodes a cell autonomous suppressor.
  Moore KJ, Swing DA, Copeland NG, Jenkins NA
  Genetics. 1994
  PubMed ID: 7828830
   
  
• Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
  Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, Ihle JN
  Mol Cell Biol. 1994
  PubMed ID: 8007943
   
  
• Soluble CTLA-4 can suppress autoantibody production and elicit long term unresponsiveness in a novel transgenic model.
  Milich DR, Linsley PS, Hughes JL, Jones JE
  J Immunol. 1994
  PubMed ID: 7515930
   
  
• In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice.
  Blazar BR, Taylor PA, Linsley PS, Vallera DA
  Blood. 1994
  PubMed ID: 7515723
   
  
• Genetic mapping of 40 cDNA clones on the mouse genome by PCR.
  Ko MS, Wang X, Horton JH, Hagen MD, Takahashi N, Maezaki Y, Nadeau JH
  Mamm Genome. 1994
  PubMed ID: 8043949
   
  
• Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11.
  Kou K, James PL, Clemmons DR, Copeland NG, Gilbert DJ, Jenkins NA, Rotwein P
  Genomics. 1994
  PubMed ID: 7525452
   
  
• Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.
  Chen C, Gault A, Shen L, Nabavi N
  J Immunol. 1994
  PubMed ID: 7513726
   
  
• Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
  Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MS, Thurston SJ, Birkenmeier EH
  Mamm Genome. 1994
  PubMed ID: 8075499
   
  
• Organization, expression, and chromosomal location of the mouse insulin-like growth factor binding protein 5 gene.
  Kou K, Jenkins NA, Gilbert DJ, Copeland NG, Rotwein P
  Genomics. 1994
  PubMed ID: 7518410
   
  
• Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.
  Freeman GJ, Borriello F, Hodes RJ, Reiser H, Gribben JG, Ng JW, Kim J, Goldberg JM, Hathcock K, Laszlo G
  J Exp Med. 1993
  PubMed ID: 7504059
   
  
• B70 antigen is a second ligand for CTLA-4 and CD28.
  Azuma M, Ito D, Yagita H, Okumura K, Phillips JH, Lanier LL, Somoza C
  Nature. 1993
  PubMed ID: 7694153
   
  
• Murine chromosomal location of four class III POU transcription factors.
  Avraham KB, Cho BC, Gilbert D, Fujii H, Okamoto K, Shimazaki T, Ito T, Shoji H, Wakamatsu Y, Kondoh H
  Genomics. 1993
  PubMed ID: 8276397
   
  
• Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.
  Lane P, Gerhard W, Hubele S, Lanzavecchia A, McConnell F
  Immunology. 1993
  PubMed ID: 8244464
   
  
• Chromosomal localization of mouse bullous pemphigoid antigens. BPAG1 and BPAG2: identification of a new region of homology between mouse and human chromosomes.
  Copeland NG, Gilbert DJ, Li K, Sawamura D, Giudice GJ, Chu ML, Jenkins NA, Uitto J
  Genomics. 1993
  PubMed ID: 8432531
   
  
• CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production.
  Freeman GJ, Lombard DB, Gimmi CD, Brod SA, Lee K, Laning JC, Hafler DA, Dorf ME, Gray GS, Reiser H
  J Immunol. 1992
  PubMed ID: 1281186
   
  
• The mouse CREB (cAMP responsive element binding protein) gene: structure, promoter analysis, and chromosomal localization.
  Cole TJ, Copeland NG, Gilbert DJ, Jenkins NA, Schütz G, Ruppert S
  Genomics. 1992
  PubMed ID: 1387109
   
  
• Quantitative polymerase chain reaction analysis of cytotoxic cell proteinase gene transcripts in T cells. Pattern of expression is dependent on the nature of the stimulus.
  Prendergast JA, Helgason CD, Bleackley RC
  J Biol Chem. 1992
  PubMed ID: 1544892
   
  
• A set of anonymous DNA clones as markers for mouse gene mapping.
  Le Roy H, Simon-Chazottes D, Montagutelli X, Guénet JL
  Mamm Genome. 1992
  PubMed ID: 1351769
   
  
• Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
  Colombo MP, Martinotti A, Howard TA, Schneider C, D'Eustachio P, Seldin MF
  Mamm Genome. 1992
  PubMed ID: 1347472
   
  
• Pax: a murine multigene family of paired box-containing genes.
  Walther C, Guenet JL, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P
  Genomics. 1991
  PubMed ID: 1685142
   
  
• CTLA-4 is a second receptor for the B cell activation antigen B7.
  Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA
  J Exp Med. 1991
  PubMed ID: 1714933
   
  
• Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping.
  Tominaga S, Jenkins NA, Gilbert DJ, Copeland NG, Tetsuka T
  Biochim Biophys Acta. 1991
  PubMed ID: 1832015
   
  
• CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
  Harper K, Balzano C, Rouvier E, Mattéi MG, Luciani MF, Golstein P
  J Immunol. 1991
  PubMed ID: 1713603
   
  
• Chromosomal location of murine and human IL-1 receptor genes.
  Copeland NG, Silan CM, Kingsley DM, Jenkins NA, Cannizzaro LA, Croce CM, Huebner K, Sims JE
  Genomics. 1991
  PubMed ID: 1672292
   
  
• Cd28 and Ctla-4, two related members of the Ig supergene family, are tightly linked on proximal mouse chromosome 1.
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