Home NKX2-5
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Regions Overlapping this Feature:
Mouse: 1
Linkage Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd16 | Mouse | chr17:26318983..29405394 | 3.09 | 75 | 3 no lod score |
(Human) GRCh37 - chr5:172659107..172662360 (3.25 kb) View in Genome Browser
(Mouse) NCBIM37 - chr17:26975609..26978510 (2.90 kb) View in Genome Browser
(Rat) RGSC3.4 - chr10:16606183..16608952 (2.77 kb) View in Genome Browser
HaemAtlas Expression Table for NKX2-5:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for NKX2-5:The NKX2-5 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| NKX2-5 | CSNK2A1 | HPRD | empirical | 9858576 |
| NKX2-5 | HIPK1 | HPRD | empirical | 9748262 |
| NKX2-5 | CAMTA2 | HPRD, IntAct, BioGRID | empirical | 16678093 |
| NKX2-5 | GATA4 | HPRD, IntAct, MIPS, BioGRID | empirical | 9312027 10948187 12845333 9584153 |
| NKX2-5 | HIPK2 | HPRD | empirical | 9748262 |
| NKX2-5 | HDAC1 | BioGRID | empirical | 18851995 |
| NKX2-5 | ID1 | BioGRID | empirical | 16556596 |
| NKX2-5 | ID2 | BioGRID | empirical | 16556596 |
| NKX2-5 | ID3 | BioGRID | empirical | 16556596 |
| NKX2-5 | JARID2 | HPRD, IntAct | empirical | 15542826 |
| NKX2-5 | SMAD4 | BioGRID | empirical | 21152044 |
| NKX2-5 | SMARCA4 | BioGRID | empirical | 15525990 |
| NKX2-5 | SRF | HPRD, BioGRID | empirical | 8887666 |
| NKX2-5 | TBX2 | HPRD | empirical | 12023302 |
| NKX2-5 | TBX5 | HPRD, IntAct, BioGRID | empirical | 11431700 12845333 |
| NKX2-5 | TLE1 | BioGRID | empirical | 20211142 |
| NKX2-5 | FOXH1 | HPRD, BioGRID | empirical | 15363409 20211142 |
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Type 1 Diabetes Publications: 3
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The Cellular Prion Protein Identifies Bipotential Cardiomyogenic Progenitors.
Hidaka K, Shirai M, Lee JK, Wakayama T, Kodama I, Schneider MD, Morisaki T
Circ Res. 2009
PubMed ID: 19910576
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Isl1 expression at the venous pole identifies a novel role for the second heart field in cardiac development.
Snarr BS, O'Neal JL, Chintalapudi MR, Wirrig EE, Phelps AL, Kubalak SW, Wessels A
Circ Res. 2007
PubMed ID: 17947796
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Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.
Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai CL, Chen J, Evans SM
Dev Biol. 2007
PubMed ID: 17258700
Publications: 437
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Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.
Cai X, Nomura-Kitabayashi A, Cai W, Yan J, Christoffels VM, Cai CL
Dev Biol. 2011
PubMed ID: 21983003
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Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression.
Madabhushi M, Lacy E
Dev Cell. 2011
PubMed ID: 22075149
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Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice.
Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC
Dev Dyn. 2011
PubMed ID: 22012595
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Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.
Warren SA, Terada R, Briggs LE, Cole-Jeffrey CT, Chien WM, Seki T, Weinberg EO, Yang TP, Chin MT, Bungert J, Kasahara H
Mol Cell Biol. 2011
PubMed ID: 21930795
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Essential roles of ECAT15-2/Dppa2 in functional lung development.
Nakamura T, Nakagawa M, Ichisaka T, Shiota A, Yamanaka S
Mol Cell Biol. 2011
PubMed ID: 21896782
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GATA5 interacts with GATA4 and GATA6 in outflow tract development.
Laforest B, Nemer M
Dev Biol. 2011
PubMed ID: 21839733
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Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart.
Esposito G, Butler TL, Blue GM, Cole AD, Sholler GF, Kirk EP, Grossfeld P, Perryman BM, Harvey RP, Winlaw DS
Am J Med Genet A. 2011
PubMed ID: 22043484
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The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation.
Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ
Nat Cell Biol. 2011
PubMed ID: 21822279
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Ebstein anomaly: Genetic heterogeneity and association with microdeletions 1p36 and 8p23.1.
Digilio MC, Bernardini L, Lepri F, Giuffrida MG, Guida V, Baban A, Versacci P, Capolino R, Torres B, De Luca A, Novelli A, Marino B, Dallapiccola B
Am J Med Genet A. 2011
PubMed ID: 21815254
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Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL
Dev Biol. 2011
PubMed ID: 21664901
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Ectopic expression of Nkx2.5 suppresses the formation of the sinoatrial node in mice.
Espinoza-Lewis RA, Liu H, Sun C, Chen C, Jiao K, Chen Y
Dev Biol. 2011
PubMed ID: 21640717
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Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation.
Olaopa M, Zhou HM, Snider P, Wang J, Schwartz RJ, Moon AM, Conway SJ
Dev Biol. 2011
PubMed ID: 21600894
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Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development.
del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21768366
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Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation.
Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H
Cardiovasc Res. 2011
PubMed ID: 21285290
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Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.
Migeotte I, Grego-Bessa J, Anderson KV
Development. 2011
PubMed ID: 21693517
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Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias.
Hahurij ND, Kolditz DP, Bökenkamp R, Markwald RR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Blom NA
Pediatr Res. 2011
PubMed ID: 21399557
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Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field.
Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H
J Mol Cell Cardiol. 2011
PubMed ID: 21382375
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miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.
Crippa S, Cassano M, Messina G, Galli D, Galvez BG, Curk T, Altomare C, Ronzoni F, Toelen J, Gijsbers R, Debyser Z, Janssens S, Zupan B, Zaza A, Cossu G, Sampaolesi M
J Cell Biol. 2011
PubMed ID: 21708977
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Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R
J Cell Biol. 2011
PubMed ID: 21690310
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Essential roles of fibronectin in the development of the left-right embryonic body plan.
Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S
Dev Biol. 2011
PubMed ID: 21466802
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Sequence variations of NKX2-5 and HAND1 genes in patients with atrial isomerism.
Hatemi AC, Güleç C, Cine N, Vural B, Hatırnaz O, Sayitoğlu M, Oztunç F, Saltık L, Kansız E, Erginel Ünaltuna N
Anadolu Kardiyol Derg. 2011
PubMed ID: 21561848
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Investigation of somatic NKX2-5, GATA4 and HAND1 mutations in patients with tetralogy of Fallot.
Wang J, Lu Y, Chen H, Yin M, Yu T, Fu Q
Pathology. 2011
PubMed ID: 21519287
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PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.
Chinchilla A, Daimi H, Lozano-Velasco E, Dominguez JN, Caballero R, Delpón E, Tamargo J, Cinca J, Hove-Madsen L, Aranega AE, Franco D
Circ Cardiovasc Genet. 2011
PubMed ID: 21511879
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Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.
Liu H, Chen CH, Espinoza-Lewis RA, Jiao Z, Sheu I, Hu X, Lin M, Zhang Y, Chen Y
J Biol Chem. 2011
PubMed ID: 21454626
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Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway.
Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, Kubota M, Noda M, Ogawa S, Shirato H, Sato M, Suzuki-Migishima R, Hino T, Satoh Y, Kitagawa M, Takeuchi T
Development. 2011
PubMed ID: 21447557
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IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development.
Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Brüning JC, Pashmforoush M, Sucov HM
Development. 2011
PubMed ID: 21429986
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Search of somatic GATA4 and NKX2.5 gene mutations in sporadic septal heart defects.
Salazar M, Consoli F, Villegas V, Caicedo V, Maddaloni V, Daniele P, Caianiello G, Pachón S, Nuñez F, Limongelli G, Pacileo G, Marino B, Bernal JE, De Luca A, Dallapiccola B
Eur J Med Genet. 2011
PubMed ID: 21276881
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Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.
Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF
Science. 2011
PubMed ID: 21512031
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A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis.
Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X
J Clin Invest. 2011
PubMed ID: 21364285
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Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Pérez-Pomares JM, de la Pompa JL
Circ Res. 2011
PubMed ID: 21311046
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Identifying novel mutations of NKX2-5 congenital heart disease patients of Chinese minority groups.
Wang J, Chen Q, Wang L, Zhou S, Cheng L, Xie X, Huang G, Wang B, Ma X
Int J Cardiol. 2011
PubMed ID: 21262546
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NKX2.5 mutations and congenital heart disease: is it a marker of cardiac anomalies?
Balci MM, Akdemir R
Int J Cardiol. 2011
PubMed ID: 19217179
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Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis.
Lopes Floro K, Artap ST, Preis JI, Fatkin D, Chapman G, Furtado MB, Harvey RP, Hamada H, Sparrow DB, Dunwoodie SL
Hum Mol Genet. 2011
PubMed ID: 21224256
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A novel NKX2-5 mutation in familial ventricular septal defect.
Wang J, Xin YF, Liu XY, Liu ZM, Wang XZ, Yang YQ
Int J Mol Med. 2011
PubMed ID: 21165553
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The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
Schlesinger J, Schueler M, Grunert M, Fischer JJ, Zhang Q, Krueger T, Lange M, Tönjes M, Dunkel I, Sperling SR
PLoS Genet. 2011
PubMed ID: 21379568
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Novel NKX2-5 mutations in patients with familial atrial septal defects.
Liu XY, Wang J, Yang YQ, Zhang YY, Chen XZ, Zhang W, Wang XZ, Zheng JH, Chen YH
Pediatr Cardiol. 2011
PubMed ID: 21188375
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HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.
Kueh AJ, Dixon MP, Voss AK, Thomas T
Mol Cell Biol. 2011
PubMed ID: 21149574
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A de novo mutation in NKX2.5 associated with atrial septal defects, ventricular noncompaction, syncope and sudden death.
Ouyang P, Saarel E, Bai Y, Luo C, Lv Q, Xu Y, Wang F, Fan C, Younoszai A, Chen Q, Tu X, Wang QK
Clin Chim Acta. 2011
PubMed ID: 20932824
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Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart.
Zeng B, Ren XF, Cao F, Zhou XY, Zhang J
J Biomed Sci. 2011
PubMed ID: 21871065
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Overexpression of Csx/Nkx2.5 and GATA-4 enhances the efficacy of mesenchymal stem cell transplantation after myocardial infarction.
Gao XR, Tan YZ, Wang HJ
Circ J. 2011
PubMed ID: 21828931
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Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.
Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV
PLoS One. 2011
PubMed ID: 21779394
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Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
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Expression of sumoylation deficient Nkx2.5 mutant in Nkx2.5 haploinsufficient mice leads to congenital heart defects.
Kim EY, Chen L, Ma Y, Yu W, Chang J, Moskowitz IP, Wang J
PLoS One. 2011
PubMed ID: 21677783
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W
Development. 2011
PubMed ID: 21177343
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Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism.
Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF
Dev Cell. 2010
PubMed ID: 21145505
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Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease.
Peng T, Wang L, Zhou SF, Li X
Genetica. 2010
PubMed ID: 21110066
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Single-nucleotide polymorphisms of NKX2.5 found in congenital heart disease patients of Mysore, South India.
Dinesh SM, Kusuma L, Smitha R, Savitha MR, Krishnamurthy B, Narayanappa D, Ramachandra NB
Genet Test Mol Biomarkers. 2010
PubMed ID: 21091212
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Expression of Slit and Robo genes in the developing mouse heart.
Medioni C, Bertrand N, Mesbah K, Hudry B, Dupays L, Wolstein O, Washkowitz AJ, Papaioannou VE, Mohun TJ, Harvey RP, Zaffran S
Dev Dyn. 2010
PubMed ID: 20941780
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Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.
Chang Z, Zhang Q, Feng Q, Xu J, Teng T, Luan Q, Shan C, Hu Y, Hemmings BA, Gao X, Yang Z
Dev Biol. 2010
PubMed ID: 20816796
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The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation.
Zhang J, Chang JY, Huang Y, Lin X, Luo Y, Schwartz RJ, Martin JF, Wang F
Circ Res. 2010
PubMed ID: 20847311
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An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.
Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20974940
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Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation.
Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H
Development. 2010
PubMed ID: 20929948
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NKX2-5: an update on this hypermutable homeodomain protein and its role in human congenital heart disease (CHD).
Reamon-Buettner SM, Borlak J
Hum Mutat. 2010
PubMed ID: 20725931
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The transcription factor GATA-6 regulates pathological cardiac hypertrophy.
van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2010
PubMed ID: 20705924
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Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
Luna-Zurita L, Prados B, Grego-Bessa J, Luxán G, del Monte G, Benguría A, Adams RH, Pérez-Pomares JM, de la Pompa JL
J Clin Invest. 2010
PubMed ID: 20890042
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Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability.
Firulli BA, McConville DP, Byers JS, Vincentz JW, Barnes RM, Firulli AB
Dev Dyn. 2010
PubMed ID: 20737509
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression.
Lu T, Pelacho B, Hao H, Luo M, Zhu J, Verfaillie CM, Tian J, Liu Z
Tissue Eng Part A. 2010
PubMed ID: 20486789
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Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.
Lai D, Liu X, Forrai A, Wolstein O, Michalicek J, Ahmed I, Garratt AN, Birchmeier C, Zhou M, Hartley L, Robb L, Feneley MP, Fatkin D, Harvey RP
Circ Res. 2010
PubMed ID: 20651287
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Clinical and genetic investigation of pediatric cases of Wolff-Parkinson-White syndrome in Tunisian families.
Nouira S, Ouarda F, Charfeddine C, Arfa I, Ouragini H, Abid F, Abdelhak S
Heart Lung. 2010
PubMed ID: 20561859
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Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms.
Zhang Y, Li S, Yuan L, Tian Y, Weidenfeld J, Yang J, Liu F, Chokas AL, Morrisey EE
Genes Dev. 2010
PubMed ID: 20713518
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Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.
Urbanek K, Cabral-da-Silva MC, Ide-Iwata N, Maestroni S, Delucchi F, Zheng H, Ferreira-Martins J, Ogórek B, D'Amario D, Bauer M, Zerbini G, Rota M, Hosoda T, Liao R, Anversa P, Kajstura J, Leri A
Circ Res. 2010
PubMed ID: 20558824
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New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.
De Luca A, Sarkozy A, Ferese R, Consoli F, Lepri F, Dentici ML, Vergara P, De Zorzi A, Versacci P, Digilio MC, Marino B, Dallapiccola B
Clin Genet. 2010
PubMed ID: 20807224
-
Cardiac malformations in Pdgfralpha mutant embryos are associated with increased expression of WT1 and Nkx2.5 in the second heart field.
Bax NA, Bleyl SB, Gallini R, Wisse LJ, Hunter J, Van Oorschot AA, Mahtab EA, Lie-Venema H, Goumans MJ, Betsholtz C, Gittenberger-de Groot AC
Dev Dyn. 2010
PubMed ID: 20658695
-
Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells.
Snyder M, Huang XY, Zhang JJ
J Biol Chem. 2010
PubMed ID: 20522556
-
Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.
Kwabi-Addo B, Wang S, Chung W, Jelinek J, Patierno SR, Wang BD, Andrawis R, Lee NH, Apprey V, Issa JP, Ittmann M
Clin Cancer Res. 2010
PubMed ID: 20606036
-
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.
Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y
Nature. 2010
PubMed ID: 20562861
-
Chromatin regulation by Brg1 underlies heart muscle development and disease.
Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP
Nature. 2010
PubMed ID: 20596014
-
Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis.
Barth JL, Clark CD, Fresco VM, Knoll EP, Lee B, Argraves WS, Lee KH
Dev Dyn. 2010
PubMed ID: 20549724
-
Pref-1 interacts with fibronectin to inhibit adipocyte differentiation.
Wang Y, Zhao L, Smas C, Sul HS
Mol Cell Biol. 2010
PubMed ID: 20457810
-
The sinus venosus progenitors separate and diversify from the first and second heart fields early in development.
Mommersteeg MT, Domínguez JN, Wiese C, Norden J, de Gier-de Vries C, Burch JB, Kispert A, Brown NA, Moorman AF, Christoffels VM
Cardiovasc Res. 2010
PubMed ID: 20110338
-
The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.
Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE
Dev Biol. 2010
PubMed ID: 20347762
-
Dioxin exposure disrupts the differentiation of mouse embryonic stem cells into cardiomyocytes.
Wang Y, Fan Y, Puga A
Toxicol Sci. 2010
PubMed ID: 20130022
-
Comprehensive genotype-phenotype analysis in 230 patients with tetralogy of Fallot.
Rauch R, Hofbeck M, Zweier C, Koch A, Zink S, Trautmann U, Hoyer J, Kaulitz R, Singer H, Rauch A
J Med Genet. 2010
PubMed ID: 19948535
-
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.
Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET
Mol Cell. 2010
PubMed ID: 20417598
-
Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease.
Stallmeyer B, Fenge H, Nowak-Göttl U, Schulze-Bahr E
Clin Genet. 2010
PubMed ID: 20456451
-
Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.
Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJ, Englert C, Petry M, Mommersteeg MT, Christoffels VM, Niederreither K, Kispert A
Circ Res. 2010
PubMed ID: 20185795
-
Zac1 is an essential transcription factor for cardiac morphogenesis.
Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, Kaneda R, Murata M, Hattori F, Makino S, Sano M, Ogawa S, Prall OW, Harvey RP, Fukuda K
Circ Res. 2010
PubMed ID: 20167925
-
Transcription factor mutations and congenital hypothyroidism: systematic genetic screening of a population-based cohort of Japanese patients.
Narumi S, Muroya K, Asakura Y, Adachi M, Hasegawa T
J Clin Endocrinol Metab. 2010
PubMed ID: 20157192
-
Heterogeneity of genetic modifiers ensures normal cardiac development.
Winston JB, Erlich JM, Green CA, Aluko A, Kaiser KA, Takematsu M, Barlow RS, Sureka AO, LaPage MJ, Janss LL, Jay PY
Circulation. 2010
PubMed ID: 20212279
-
Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation.
Li P, Pashmforoush M, Sucov HM
Dev Cell. 2010
PubMed ID: 20230754
-
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
-
G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs.
Shimoji K, Yuasa S, Onizuka T, Hattori F, Tanaka T, Hara M, Ohno Y, Chen H, Egasgira T, Seki T, Yae K, Koshimizu U, Ogawa S, Fukuda K
Cell Stem Cell. 2010
PubMed ID: 20207226
-
A whole genome association study of mother-to-child transmission of HIV in Malawi.
Joubert BR, Lange EM, Franceschini N, Mwapasa V, North KE, Meshnick SR, the NIAID Center for HIV/AIDS Vaccine Immunology
Genome Med. 2010
PubMed ID: 20487506
-
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.
Maillet M, Davis J, Auger-Messier M, York A, Osinska H, Piquereau J, Lorenz JN, Robbins J, Ventura-Clapier R, Molkentin JD
J Biol Chem. 2010
PubMed ID: 20037164
-
Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F
Circ Res. 2010
PubMed ID: 20007915
-
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.
Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE
Dev Cell. 2010
PubMed ID: 20159597
-
Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.
Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY
J Clin Invest. 2010
PubMed ID: 20071776
-
Genome-wide association study of PR interval.
Pfeufer A, van Noord C, Marciante KD, Arking DE, Larson MG, Smith AV, Tarasov KV, Müller M, Sotoodehnia N, Sinner MF, Verwoert GC, Li M, Kao WH, Köttgen A, Coresh J, Bis JC, Psaty BM, Rice K, Rotter JI, Rivadeneira F, Hofman A, Kors JA, Stricker BH, Uitterlinden AG, van Duijn CM, Beckmann BM, Sauter W, Gieger C, Lubitz SA, Newton-Cheh C, Wang TJ, Magnani JW, Schnabel RB, Chung MK, Barnard J, Smith JD, Van Wagoner DR, Vasan RS, Aspelund T, Eiriksdottir G, Harris TB, Launer LJ, Najjar SS, Lakatta E, Schlessinger D, Uda M, Abecasis GR, Müller-Myhsok B, Ehret GB, Boerwinkle E, Chakravarti A, Soliman EZ, Lunetta KL, Perz S, Wichmann HE, Meitinger T, Levy D, Gudnason V, Ellinor PT, Sanna S, Kääb S, Witteman JC, Alonso A, Benjamin EJ, Heckbert SR
Nat Genet. 2010
PubMed ID: 20062060
-
Nkx2.5/Csx represses myofibroblast differentiation.
Hu B, Wu YM, Wu Z, Phan SH
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19395679
-
Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure.
Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD
Circulation. 2010
PubMed ID: 20065166
-
miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation.
Saxena A, Tabin CJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20018673
-
Hyaluronan esters drive Smad gene expression and signaling enhancing cardiogenesis in mouse embryonic and human mesenchymal stem cells.
Maioli M, Santaniello S, Montella A, Bandiera P, Cantoni S, Cavallini C, Bianchi F, Lionetti V, Rizzolio F, Marchesi I, Bagella L, Ventura C
PLoS One. 2010
PubMed ID: 21152044
-
Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain.
Hammock EA, Eagleson KL, Barlow S, Earls LR, Miller DM, Levitt P
Neural Dev. 2010
PubMed ID: 21122108
-
Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.
Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H
PLoS One. 2010
PubMed ID: 20824138
-
Cardiac deletion of Smyd2 is dispensable for mouse heart development.
Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Böttger T, Harvey RP, Tucker PW, Engel FB
PLoS One. 2010
PubMed ID: 20305823
-
Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.
Baur F, Nau K, Sadic D, Allweiss L, Elsässer HP, Gillemans N, de Wit T, Krüger I, Vollmer M, Philipsen S, Suske G
PLoS One. 2010
PubMed ID: 20221402
-
Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.
Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Räsänen J, Vainio SJ
Cardiovasc Res. 2010
PubMed ID: 19622544
-
Mutational analysis of the PITX2 and NKX2-5 genes in patients with idiopathic atrial fibrillation.
Boldt LH, Posch MG, Perrot A, Polotzki M, Rolf S, Parwani AS, Huemer M, Wutzler A, Ozcelik C, Haverkamp W
Int J Cardiol. 2009
PubMed ID: 20022124
-
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
-
Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.
Lanier J, Dykes IM, Nissen S, Eng SR, Turner EE
Dev Dyn. 2009
PubMed ID: 19877281
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
-
Forward programming of pluripotent stem cells towards distinct cardiovascular cell types.
David R, Stieber J, Fischer E, Brunner S, Brenner C, Pfeiler S, Schwarz F, Franz WM
Cardiovasc Res. 2009
PubMed ID: 19564151
-
Six2 activity is required for the formation of the mammalian pyloric sphincter.
Self M, Geng X, Oliver G
Dev Biol. 2009
PubMed ID: 19660448
-
Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis.
Li C, Li A, Li M, Xing Y, Chen H, Hu L, Tiozzo C, Anderson S, Taketo MM, Minoo P
Dev Biol. 2009
PubMed ID: 19631635
-
[Novel NKX2-5 mutations identified in patients with congenital ventricular septal defects]
Liu XY, Yang YQ, Yang Y, Lin XP, Chen YH
Zhonghua Yi Xue Za Zhi. 2009
PubMed ID: 20137692
-
Reptilian heart development and the molecular basis of cardiac chamber evolution.
Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG
Nature. 2009
PubMed ID: 19727199
-
[Mutation of NKX2-5 gene in patients with atrial septal defect]
Liu XY, Yang YQ, Yang Y, Lin XP, Chen YH
Zhonghua Er Ke Za Zhi. 2009
PubMed ID: 20021795
-
Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.
Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706423
-
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.
Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H
Lab Invest. 2009
PubMed ID: 19546853
-
Mutations in the NKX2-5 gene in patients with stroke and patent foramen ovale.
Belvís R, Tizzano EF, Martí-Fàbregas J, Leta RG, Baena M, Carreras F, Pons-Lladó G, Baiget M, Martí-Vilalta JL
Clin Neurol Neurosurg. 2009
PubMed ID: 19464101
-
Assessment of embryonic myocardial cell differentiation using a dual fluorescent reporter system.
McMullen NM, Zhang F, Pasumarthi KB
J Cell Mol Med. 2009
PubMed ID: 18624775
-
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Nimura K, Ura K, Shiratori H, Ikawa M, Okabe M, Schwartz RJ, Kaneda Y
Nature. 2009
PubMed ID: 19483677
-
Molecular analysis of PRKAG2, LAMP2, and NKX2-5 genes in a cohort of 125 patients with accessory atrioventricular connection.
Esposito G, Grutter G, Drago F, Costa MW, De Santis A, Bosco G, Marino B, Bellacchio E, Lepri F, Harvey RP, Sarkozy A, Dallapiccola B
Am J Med Genet A. 2009
PubMed ID: 19533775
-
Cardiac differentiation is driven by NKX2.5 and GATA4 nuclear translocation in tissue-specific mesenchymal stem cells.
Armiñán A, Gandía C, Bartual M, García-Verdugo JM, Lledó E, Mirabet V, Llop M, Barea J, Montero JA, Sepúlveda P
Stem Cells Dev. 2009
PubMed ID: 18983250
-
Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF).
Yoshimura K, Kitagawa H, Fujiki R, Tanabe M, Takezawa S, Takada I, Yamaoka I, Yonezawa M, Kondo T, Furutani Y, Yagi H, Yoshinaga S, Masuda T, Fukuda T, Yamamoto Y, Ebihara K, Li DY, Matsuoka R, Takeuchi JK, Matsumoto T, Kato S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19470456
-
Distinct origins and genetic programs of head muscle satellite cells.
Harel I, Nathan E, Tirosh-Finkel L, Zigdon H, Guimarães-Camboa N, Evans SM, Tzahor E
Dev Cell. 2009
PubMed ID: 19531353
-
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT
J Clin Invest. 2009
PubMed ID: 19411759
-
Multiple roles for Sox2 in the developing and adult mouse trachea.
Que J, Luo X, Schwartz RJ, Hogan BL
Development. 2009
PubMed ID: 19403656
-
Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth.
DiMichele LA, Hakim ZS, Sayers RL, Rojas M, Schwartz RJ, Mack CP, Taylor JM
Circ Res. 2009
PubMed ID: 19372463
-
Genetic fate mapping identifies second heart field progenitor cells as a source of adipocytes in arrhythmogenic right ventricular cardiomyopathy.
Lombardi R, Dong J, Rodriguez G, Bell A, Leung TK, Schwartz RJ, Willerson JT, Brugada R, Marian AJ
Circ Res. 2009
PubMed ID: 19359597
-
Activation of Tolloid-like 1 gene expression by the cardiac specific homeobox gene Nkx2-5.
Sabirzhanova I, Sabirzhanov B, Bjordahl J, Brandt J, Jay PY, Clark TG
Dev Growth Differ. 2009
PubMed ID: 19366374
-
Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development.
Verzi MP, Stanfel MN, Moses KA, Kim BM, Zhang Y, Schwartz RJ, Shivdasani RA, Zimmer WE
Gastroenterology. 2009
PubMed ID: 19208343
-
[Preliminary exploration of transcription factor Nkx2.5 mutations and congenital heart diseases]
Ding JD, Li KR, Zhang XL, Yao YY, Reng LQ, Tao SY, Fang X, Ma GS
Zhonghua Yi Xue Za Zhi. 2009
PubMed ID: 19595143
-
Tbx18 and the fate of epicardial progenitors.
Christoffels VM, Grieskamp T, Norden J, Mommersteeg MT, Rudat C, Kispert A
Nature. 2009
PubMed ID: 19369973
-
Screening NKX2.5 mutation in a sample of 230 Han Chinese children with congenital heart diseases.
Zhang W, Li X, Shen A, Jiao W, Guan X, Li Z
Genet Test Mol Biomarkers. 2009
PubMed ID: 19371212
-
Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5.
Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y
Dev Biol. 2009
PubMed ID: 19166829
-
Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.
Goldman DC, Donley N, Christian JL
Mech Dev. 2009
PubMed ID: 19116164
-
GATA4 and NKX2.5 gene analysis in Chinese Uygur patients with congenital heart disease.
Zhang WM, Li XF, Ma ZY, Zhang J, Zhou SH, Li T, Shi L, Li ZZ
Chin Med J (Engl). 2009
PubMed ID: 19302747
-
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.
Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V
Dev Biol. 2009
PubMed ID: 19084512
-
Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3.
Wiese C, Grieskamp T, Airik R, Mommersteeg MT, Gardiwal A, de Gier-de Vries C, Schuster-Gossler K, Moorman AF, Kispert A, Christoffels VM
Circ Res. 2009
PubMed ID: 19096026
-
Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling.
Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D
Dev Cell. 2009
PubMed ID: 19217425
-
Investigation of somatic NKX2-5 mutations in congenital heart disease.
Draus JM, Hauck MA, Goetsch M, Austin EH, Tomita-Mitchell A, Mitchell ME
J Med Genet. 2009
PubMed ID: 19181906
-
Prox1 maintains muscle structure and growth in the developing heart.
Risebro CA, Searles RG, Melville AA, Ehler E, Jina N, Shah S, Pallas J, Hubank M, Dillard M, Harvey NL, Schwartz RJ, Chien KR, Oliver G, Riley PR
Development. 2009
PubMed ID: 19091769
-
Familial atrial septal defect in the oval fossa with progressive prolongation of the atrioventricular conduction caused by mutations in the NKX2.5 gene.
Bjørnstad PG, Leren TP
Cardiol Young. 2009
PubMed ID: 19049681
-
WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.
Liu Z, Li T, Liu Y, Jia Z, Li Y, Zhang C, Chen P, Ma K, Affara N, Zhou C
Biochim Biophys Acta. 2009
PubMed ID: 18851995
-
17 beta-estradiol modulates expression of low-voltage-activated Ca(V)3.2 T-type calcium channel via extracellularly regulated kinase pathway in cardiomyocytes.
Marni F, Wang Y, Morishima M, Shimaoka T, Uchino T, Zheng M, Kaku T, Ono K
Endocrinology. 2009
PubMed ID: 18832095
-
Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo.
Ferdous A, Caprioli A, Iacovino M, Martin CM, Morris J, Richardson JA, Latif S, Hammer RE, Harvey RP, Olson EN, Kyba M, Garry DJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19129488
-
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS
PLoS One. 2009
PubMed ID: 19479054
-
Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node.
Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, DeRuiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC
Dev Dyn. 2009
PubMed ID: 19097191
-
Clinical and molecular analysis of thyroid hypoplasia: a population-based approach in southern Brazil.
Ramos HE, Nesi-França S, Boldarine VT, Pereira RM, Chiamolera MI, Camacho CP, Graf H, de Lacerda L, Carvalho GA, Maciel RM
Thyroid. 2009
PubMed ID: 18976153
-
Pulmonary vein, dorsal atrial wall and atrial septum abnormalities in podoplanin knockout mice with disturbed posterior heart field contribution.
Douglas YL, Mahtab EA, Jongbloed MR, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Deruiter MC, Gittenberger-de Groot AC
Pediatr Res. 2009
PubMed ID: 18784615
-
NKX2.5 mutations in patients with non-syndromic congenital heart disease.
Gioli-Pereira L, Pereira AC, Mesquita SM, Xavier-Neto J, Lopes AA, Krieger JE
Int J Cardiol. 2008
PubMed ID: 19073351
-
Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development.
Vincentz JW, Barnes RM, Firulli BA, Conway SJ, Firulli AB
Dev Dyn. 2008
PubMed ID: 19035347
-
NKX2.5/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases.
Khetyar M, Tinworth L, Syrris P, Abushaban L, Abdulazzaq Y, Silengo M, Carvalho J, Carter N
Genet Test. 2008
PubMed ID: 18939937
-
Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function.
Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, Perriard JC
Circ Res. 2008
PubMed ID: 18849322
-
[The expression of GATA-4 and Nkx2.5 gene in the transformation of Rattus mesenchymal stem cells into cardiomyocytes]
Wu CX, Zhang EY, Yang SY, Ma JY, An Q, Shi YK
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008
PubMed ID: 19253817
-
Crystallization and preliminary X-ray analysis of the NKX2.5 homeodomain in complex with DNA.
Genis C, Scone P, Kasahara H, Nam HJ
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008
PubMed ID: 18997347
-
BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.
Furtado MB, Solloway MJ, Jones VJ, Costa MW, Biben C, Wolstein O, Preis JI, Sparrow DB, Saga Y, Dunwoodie SL, Robertson EJ, Tam PP, Harvey RP
Genes Dev. 2008
PubMed ID: 18981480
-
Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis.
Zhang J, Lin Y, Zhang Y, Lan Y, Lin C, Moon AM, Schwartz RJ, Martin JF, Wang F
Development. 2008
PubMed ID: 18832393
-
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity.
Ma Q, Zhou B, Pu WT
Dev Biol. 2008
PubMed ID: 18775691
-
Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium.
Zhou B, von Gise A, Ma Q, Rivera-Feliciano J, Pu WT
Biochem Biophys Res Commun. 2008
PubMed ID: 18722343
-
Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development.
Drenckhahn JD, Schwarz QP, Gray S, Laskowski A, Kiriazis H, Ming Z, Harvey RP, Du XJ, Thorburn DR, Cox TC
Dev Cell. 2008
PubMed ID: 18854137
-
Signaling via the Tgf-beta type I receptor Alk5 in heart development.
Sridurongrit S, Larsson J, Schwartz R, Ruiz-Lozano P, Kaartinen V
Dev Biol. 2008
PubMed ID: 18718461
-
Tbx3 is required for outflow tract development.
Mesbah K, Harrelson Z, Théveniau-Ruissy M, Papaioannou VE, Kelly RG
Circ Res. 2008
PubMed ID: 18723448
-
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.
Hirano M, Hashimoto S, Yonemura S, Sabe H, Aizawa S
J Cell Biol. 2008
PubMed ID: 18794329
-
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects.
Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H
Circ Res. 2008
PubMed ID: 18689573
-
Serdin1/Lrrc10 is dispensable for mouse development.
Manuylov NL, Manuylova E, Avdoshina V, Tevosian S
Genesis. 2008
PubMed ID: 18781631
-
Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.
García-García MJ, Shibata M, Anderson KV
Development. 2008
PubMed ID: 18701545
-
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.
Rojas A, Kong SW, Agarwal P, Gilliss B, Pu WT, Black BL
Mol Cell Biol. 2008
PubMed ID: 18591257
-
SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes.
Kiefer SM, Robbins L, Barina A, Zhang Z, Rauchman M
Hum Mutat. 2008
PubMed ID: 18470945
-
Regulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifier.
Wang J, Zhang H, Iyer D, Feng XH, Schwartz RJ
J Biol Chem. 2008
PubMed ID: 18579533
-
Changes of HCN gene expression and I(f) currents in Nkx2.5-positive cardiomyocytes derived from murine embryonic stem cells during differentiation.
Yano S, Miake J, Mizuta E, Manabe K, Bahrudin U, Morikawa K, Arakawa K, Sasaki N, Igawa O, Shigemasa C, Yamamoto Y, Morisaki T, Hidaka K, Kurata Y, Yoshida A, Shiota G, Higaki K, Ninomiya H, Lee JK, Shirayoshi Y, Hisatome I
Biomed Res. 2008
PubMed ID: 18724007
-
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.
Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT
Nature. 2008
PubMed ID: 18568026
-
A myocardial lineage derives from Tbx18 epicardial cells.
Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM
Nature. 2008
PubMed ID: 18480752
-
Transcriptional activation of the cardiac homeobox gene CSX1/NKX2-5 in a B-cell chronic lymphoproliferative disorder.
Su X, Della-Valle V, Delabesse E, Azgui Z, Berger R, Merle-Béral H, Bernard OA, Nguyen-Khac F
Haematologica. 2008
PubMed ID: 18492690
-
The dynamics of spleen morphogenesis.
Burn SF, Boot MJ, de Angelis C, Doohan R, Arques CG, Torres M, Hill RE
Dev Biol. 2008
PubMed ID: 18452913
-
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.
Bakker ML, Boukens BJ, Mommersteeg MT, Brons JF, Wakker V, Moorman AF, Christoffels VM
Circ Res. 2008
PubMed ID: 18467625
-
Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43.
Boogerd KJ, Wong LY, Christoffels VM, Klarenbeek M, Ruijter JM, Moorman AF, Barnett P
Cardiovasc Res. 2008
PubMed ID: 18285513
-
Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice.
Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA
Dev Biol. 2008
PubMed ID: 18400219
-
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.
Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K
Cell Stem Cell. 2008
PubMed ID: 18462699
-
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.
Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18448675
-
Identification of downstream genetic pathways of Tbx1 in the second heart field.
Liao J, Aggarwal VS, Nowotschin S, Bondarev A, Lipner S, Morrow BE
Dev Biol. 2008
PubMed ID: 18328475
-
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
-
Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development.
Domínguez JN, de la Rosa A, Navarro F, Franco D, Aránega AE
Cardiovasc Res. 2008
PubMed ID: 18178574
-
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS
Circulation. 2008
PubMed ID: 18316483
-
Identification of cardiac-specific myosin light chain kinase.
Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H
Circ Res. 2008
PubMed ID: 18202317
-
Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development.
Mahtab EA, Wijffels MC, Van Den Akker NM, Hahurij ND, Lie-Venema H, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC
Dev Dyn. 2008
PubMed ID: 18265012
-
MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines.
Nagel S, Meyer C, Quentmeier H, Kaufmann M, Drexler HG, MacLeod RA
Leukemia. 2008
PubMed ID: 18079734
-
Retinoic acid deficiency alters second heart field formation.
Ryckebusch L, Wang Z, Bertrand N, Lin SC, Chi X, Schwartz R, Zaffran S, Niederreither K
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18287057
-
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.
Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP
Dev Cell. 2008
PubMed ID: 18267097
-
Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation.
Diwan A, Wansapura J, Syed FM, Matkovich SJ, Lorenz JN, Dorn GW
Circulation. 2008
PubMed ID: 18178777
-
Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects.
Posch MG, Perrot A, Schmitt K, Mittelhaus S, Esenwein EM, Stiller B, Geier C, Dietz R, Gessner R, Ozcelik C, Berger F
Am J Med Genet A. 2008
PubMed ID: 18076106
-
Establishment and characterization of an ovarian yolk sac tumor cell line reveals possible involvement of Nkx2.5 in tumor development.
Shibata K, Kajiyama H, Yamamoto E, Terauchi M, Ino K, Nawa A, Kikkawa F
Oncology. 2008
PubMed ID: 18547965
-
A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population.
Oishi T, Iida A, Otsubo S, Kamatani Y, Usami M, Takei T, Uchida K, Tsuchiya K, Saito S, Ohnisi Y, Tokunaga K, Nitta K, Kawaguchi Y, Kamatani N, Kochi Y, Shimane K, Yamamoto K, Nakamura Y, Yumura W, Matsuda K
J Hum Genet. 2008
PubMed ID: 18219441
-
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression.
Yadava RS, Frenzel-McCardell CD, Yu Q, Srinivasan V, Tucker AL, Puymirat J, Thornton CA, Prall OW, Harvey RP, Mahadevan MS
Nat Genet. 2008
PubMed ID: 18084293
-
A novel stop mutation truncating critical regions of the cardiac transcription factor NKX2-5 in a large family with autosomal-dominant inherited congenital heart disease.
Pabst S, Wollnik B, Rohmann E, Hintz Y, Glänzer K, Vetter H, Nickenig G, Grohé C
Clin Res Cardiol. 2008
PubMed ID: 17891520
-
The effect of p.Arg25Cys alteration in NKX2-5 on conotruncal heart anomalies: mutation or polymorphism?
Akçaboy MI, Cengiz FB, Inceoğlu B, Uçar T, Atalay S, Tutar E, Tekin M
Pediatr Cardiol. 2008
PubMed ID: 17891434
-
Induction of Id2 expression by cardiac transcription factors GATA4 and Nkx2.5.
Lim JY, Kim WH, Kim J, Park SI
J Cell Biochem. 2008
PubMed ID: 17559079
-
Transcription factor Sp3 knockout mice display serious cardiac malformations.
van Loo PF, Mahtab EA, Wisse LJ, Hou J, Grosveld F, Suske G, Philipsen S, Gittenberger-de Groot AC
Mol Cell Biol. 2007
PubMed ID: 17923686
-
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18000065
-
Isolation of cardiac cells from E8.5 yolk sac by ALCAM (CD166) expression.
Murakami Y, Hirata H, Miyamoto Y, Nagahashi A, Sawa Y, Jakt M, Asahara T, Kawamata S
Mech Dev. 2007
PubMed ID: 17964124
-
Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium.
Mommersteeg MT, Brown NA, Prall OW, de Gier-de Vries C, Harvey RP, Moorman AF, Christoffels VM
Circ Res. 2007
PubMed ID: 17823370
-
Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.
Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA
Development. 2007
PubMed ID: 17855428
-
Generation of an Frs2alpha conditional null allele.
Lin Y, Zhang J, Zhang Y, Wang F
Genesis. 2007
PubMed ID: 17868091
-
Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.
Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A
J Biol Chem. 2007
PubMed ID: 17584735
-
Myocardial smad4 is essential for cardiogenesis in mouse embryos.
Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K
Circ Res. 2007
PubMed ID: 17585069
-
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.
Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP
Am J Hum Genet. 2007
PubMed ID: 17668378
-
Dynamic expression patterns of leucine-rich repeat containing protein 10 in the heart.
Kim KH, Kim TG, Micales BK, Lyons GE, Lee Y
Dev Dyn. 2007
PubMed ID: 17626279
-
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.
Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM
Mol Cell Biol. 2007
PubMed ID: 17526730
-
Carboxyl terminus of Nkx2.5 impairs its interaction with p300.
Li T, Li YM, Jia ZQ, Chen P, Ma KT, Zhou CY
J Mol Biol. 2007
PubMed ID: 17544441
-
A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development.
Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE
Cell. 2007
PubMed ID: 17604724
-
Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.
Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S
Genes Cells. 2007
PubMed ID: 17573777
-
Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart.
Wang Y, Morishima M, Zheng M, Uchino T, Mannen K, Takahashi A, Nakaya Y, Komuro I, Ono K
J Mol Cell Cardiol. 2007
PubMed ID: 17498735
-
Canonical Wnt signaling functions in second heart field to promote right ventricular growth.
Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17519332
-
Ultrastructural and immunocharacterization of undifferentiated myocardial cells in the developing mouse heart.
Zhang F, Pasumarthi KB
J Cell Mol Med. 2007
PubMed ID: 17635645
-
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.
Hoogaars WM, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P, Ravesloot JH, Moorman AF, Verheijck EE, Christoffels VM
Genes Dev. 2007
PubMed ID: 17473172
-
Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development.
Blaschke RJ, Hahurij ND, Kuijper S, Just S, Wisse LJ, Deissler K, Maxelon T, Anastassiadis K, Spitzer J, Hardt SE, Schöler H, Feitsma H, Rottbauer W, Blum M, Meijlink F, Rappold G, Gittenberger-de Groot AC
Circulation. 2007
PubMed ID: 17372176
-
Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development.
Goddeeris MM, Schwartz R, Klingensmith J, Meyers EN
Development. 2007
PubMed ID: 17344228
-
Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.
Zhu H, Wlodarczyk BJ, Scott M, Yu W, Merriweather M, Gelineau-van Waes J, Schwartz RJ, Finnell RH
Birth Defects Res A Clin Mol Teratol. 2007
PubMed ID: 17286298
-
CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression.
Koibuchi N, Chin MT
Circ Res. 2007
PubMed ID: 17332425
-
Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system.
Meysen S, Marger L, Hewett KW, Jarry-Guichard T, Agarkova I, Chauvin JP, Perriard JC, Izumo S, Gourdie RG, Mangoni ME, Nargeot J, Gros D, Miquerol L
Dev Biol. 2007
PubMed ID: 17250822
-
Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties.
Shiota M, Heike T, Haruyama M, Baba S, Tsuchiya A, Fujino H, Kobayashi H, Kato T, Umeda K, Yoshimoto M, Nakahata T
Exp Cell Res. 2007
PubMed ID: 17289022
-
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP
Cell. 2007
PubMed ID: 17350578
-
Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.
Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, Niu Z, Chen M, Schwartz RJ, Schneider MD
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360443
-
Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.
Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, Navaratnam N, Norris DP, Episkopou V
PLoS Biol. 2007
PubMed ID: 17341133
-
Molecular pathway for the localized formation of the sinoatrial node.
Mommersteeg MT, Hoogaars WM, Prall OW, de Gier-de Vries C, Wiese C, Clout DE, Papaioannou VE, Brown NA, Harvey RP, Moorman AF, Christoffels VM
Circ Res. 2007
PubMed ID: 17234970
-
Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1.
Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, Meyer C, Drexler HG, MacLeod RA
Cancer Res. 2007
PubMed ID: 17308084
-
Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells.
Yamada Y, Sakurada K, Takeda Y, Gojo S, Umezawa A
Exp Cell Res. 2007
PubMed ID: 17208226
-
Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells.
Singh AM, Li FQ, Hamazaki T, Kasahara H, Takemaru K, Terada N
Circulation. 2007
PubMed ID: 17261658
-
Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system.
Gittenberger-de Groot AC, Mahtab EA, Hahurij ND, Wisse LJ, Deruiter MC, Wijffels MC, Poelmann RE
Anat Rec (Hoboken). 2007
PubMed ID: 17441204
-
Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis.
Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO
Dev Dyn. 2007
PubMed ID: 17131407
-
Generation of conditional Cited2 null alleles.
Preis JI, Wise N, Solloway MJ, Harvey RP, Sparrow DB, Dunwoodie SL
Genesis. 2006
PubMed ID: 17133411
-
Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart.
Risebro CA, Smart N, Dupays L, Breckenridge R, Mohun TJ, Riley PR
Development. 2006
PubMed ID: 17050624
-
Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling.
Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM, Brunskill EW, Koch WJ, Schwartz RJ, Dorn GW
Circ Res. 2006
PubMed ID: 17008600
-
Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis.
Karamboulas C, Dakubo GD, Liu J, De Repentigny Y, Yutzey K, Wallace VA, Kothary R, Skerjanc IS
J Cell Sci. 2006
PubMed ID: 17003108
-
Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
Rakeman AS, Anderson KV
Development. 2006
PubMed ID: 16831833
-
A threshold of GATA4 and GATA6 expression is required for cardiovascular development.
Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16847256
-
Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field.
Rivera-Feliciano J, Tabin CJ
Dev Biol. 2006
PubMed ID: 16730346
-
Specific DNA binding by the homeodomain Nkx2.5(C56S): detection of impaired DNA or unfolded protein by isothermal titration calorimetry.
Fodor E, Ginsburg A
Proteins. 2006
PubMed ID: 16555308
-
Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18.
Christoffels VM, Mommersteeg MT, Trowe MO, Prall OW, de Gier-de Vries C, Soufan AT, Bussen M, Schuster-Gossler K, Harvey RP, Moorman AF, Kispert A
Circ Res. 2006
PubMed ID: 16709898
-
Fgf8 is required for anterior heart field development.
Ilagan R, Abu-Issa R, Brown D, Yang YP, Jiao K, Schwartz RJ, Klingensmith J, Meyers EN
Development. 2006
PubMed ID: 16720880
-
p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.
Ding B, Liu CJ, Huang Y, Yu J, Kong W, Lengyel P
J Biol Chem. 2006
PubMed ID: 16556596
-
p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.
Ding B, Liu CJ, Huang Y, Hickey RP, Yu J, Kong W, Lengyel P
J Biol Chem. 2006
PubMed ID: 16556595
-
The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.
Song K, Backs J, McAnally J, Qi X, Gerard RD, Richardson JA, Hill JA, Bassel-Duby R, Olson EN
Cell. 2006
PubMed ID: 16678093
-
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.
Watanabe Y, Kokubo H, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki K, Kanno J, Saga Y
Development. 2006
PubMed ID: 16554359
-
Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling.
Spencer-Dene B, Sala FG, Bellusci S, Gschmeissner S, Stamp G, Dickson C
Gastroenterology. 2006
PubMed ID: 16618415
-
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field.
Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M, Morrow BE
Development. 2006
PubMed ID: 16556915
-
A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery.
Elliott DA, Solloway MJ, Wise N, Biben C, Costa MW, Furtado MB, Lange M, Dunwoodie S, Harvey RP
Development. 2006
PubMed ID: 16510504
-
Missense mutation in the transcription factor NKX2-5: a novel molecular event in the pathogenesis of thyroid dysgenesis.
Dentice M, Cordeddu V, Rosica A, Ferrara AM, Santarpia L, Salvatore D, Chiovato L, Perri A, Moschini L, Fazzini C, Olivieri A, Costa P, Stoppioni V, Baserga M, De Felice M, Sorcini M, Fenzi G, Di Lauro R, Tartaglia M, Macchia PE
J Clin Endocrinol Metab. 2006
PubMed ID: 16418214
-
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.
Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2006
PubMed ID: 16514068
-
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis.
Shim JH, Xiao C, Hayden MS, Lee KY, Trombetta ES, Pypaert M, Nara A, Yoshimori T, Wilm B, Erdjument-Bromage H, Tempst P, Hogan BL, Mellman I, Ghosh S
J Cell Biol. 2006
PubMed ID: 16567502
-
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG
Nat Genet. 2006
PubMed ID: 16380715
-
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
-
Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development.
Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R
Dev Biol. 2005
PubMed ID: 16223478
-
Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning.
Ma L, Lu MF, Schwartz RJ, Martin JF
Development. 2005
PubMed ID: 16314491
-
Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.
Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP
Development. 2005
PubMed ID: 16291790
-
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development.
Zhang Z, Cerrato F, Xu H, Vitelli F, Morishima M, Vincentz J, Furuta Y, Ma L, Martin JF, Baldini A, Lindsay E
Development. 2005
PubMed ID: 16284121
-
In vivo genetic ablation by Cre-mediated expression of diphtheria toxin fragment A.
Ivanova A, Signore M, Caro N, Greene ND, Copp AJ, Martinez-Barbera JP
Genesis. 2005
PubMed ID: 16267821
-
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets.
Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ
J Biol Chem. 2005
PubMed ID: 15929941
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval.
Venturin M, Bentivegna A, Moroni R, Larizza L, Riva P
Ann Hum Genet. 2005
PubMed ID: 16138909
-
GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
Brewer AC, Alexandrovich A, Mjaatvedt CH, Shah AM, Patient RK, Pizzey JA
Stem Cells Dev. 2005
PubMed ID: 16137232
-
Functional dissection of sequence-specific NKX2-5 DNA binding domain mutations associated with human heart septation defects using a yeast-based system.
Inga A, Reamon-Buettner SM, Borlak J, Resnick MA
Hum Mol Genet. 2005
PubMed ID: 15917268
-
Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh.
Briegel KJ, Baldwin HS, Epstein JA, Joyner AL
Development. 2005
PubMed ID: 15958514
-
A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.
Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F, Cleary ML, Selleri L
Development. 2005
PubMed ID: 15944191
-
Morphogenesis of the right ventricle requires myocardial expression of Gata4.
Zeisberg EM, Ma Q, Juraszek AL, Moses K, Schwartz RJ, Izumo S, Pu WT
J Clin Invest. 2005
PubMed ID: 15902305
-
Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.
Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Bürger A, Ericson J, Kispert A
Development. 2005
PubMed ID: 15901664
-
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect.
Hirayama-Yamada K, Kamisago M, Akimoto K, Aotsuka H, Nakamura Y, Tomita H, Furutani M, Imamura S, Takao A, Nakazawa M, Matsuoka R
Am J Med Genet A. 2005
PubMed ID: 15810002
-
Dysregulation of connexins and inactivation of NFATc1 in the cardiovascular system of Nkx2-5 null mutants.
Dupays L, Jarry-Guichard T, Mazurais D, Calmels T, Izumo S, Gros D, Théveniau-Ruissy M
J Mol Cell Cardiol. 2005
PubMed ID: 15850572
-
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP
Development. 2005
PubMed ID: 15843414
-
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG
Development. 2005
PubMed ID: 15843409
-
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.
Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S
Development. 2005
PubMed ID: 15843407
-
GATA6 is essential for embryonic development of the liver but dispensable for early heart formation.
Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA
Mol Cell Biol. 2005
PubMed ID: 15767668
-
CSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitro.
Riazi AM, Lee H, Hsu C, Van Arsdell G
J Biol Chem. 2005
PubMed ID: 15653675
-
Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system.
Fiore R, Rahim B, Christoffels VM, Moorman AF, Püschel AW
Mol Cell Biol. 2005
PubMed ID: 15743826
-
Temporal and spatial expression pattern of beta1 sodium channel subunit during heart development.
Domínguez JN, Navarro F, Franco D, Thompson RP, Aránega AE
Cardiovasc Res. 2005
PubMed ID: 15721864
-
Common arterial trunk associated with a homeodomain mutation of NKX2.6.
Heathcote K, Braybrook C, Abushaban L, Guy M, Khetyar ME, Patton MA, Carter ND, Scambler PJ, Syrris P
Hum Mol Genet. 2005
PubMed ID: 15649947
-
Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system.
Kokubo H, Miyagawa-Tomita S, Nakazawa M, Saga Y, Johnson RL
Dev Biol. 2005
PubMed ID: 15680351
-
Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation.
Jay PY, Maguire CT, Wakimoto H, Izumo S, Berul CI
J Cardiovasc Electrophysiol. 2005
PubMed ID: 15673394
-
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
-
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, Ornitz DM
Dev Cell. 2005
PubMed ID: 15621532
-
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
-
Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.
Kim TG, Chen J, Sadoshima J, Lee Y
Mol Cell Biol. 2004
PubMed ID: 15542826
-
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG
Nature. 2004
PubMed ID: 15525990
-
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis.
Pu WT, Ishiwata T, Juraszek AL, Ma Q, Izumo S
Dev Biol. 2004
PubMed ID: 15464586
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.
Hecksher-Sørensen J, Watson RP, Lettice LA, Serup P, Eley L, De Angelis C, Ahlgren U, Hill RE
Development. 2004
PubMed ID: 15329346
-
The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
-
Foxh1 is essential for development of the anterior heart field.
von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL
Dev Cell. 2004
PubMed ID: 15363409
-
Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease.
Reamon-Buettner SM, Borlak J
J Med Genet. 2004
PubMed ID: 15342699
-
Transcription factor Nkx-2.5 induces sodium/iodide symporter gene expression and participates in retinoic acid- and lactation-induced transcription in mammary cells.
Dentice M, Luongo C, Elefante A, Romino R, Ambrosio R, Vitale M, Rossi G, Fenzi G, Salvatore D
Mol Cell Biol. 2004
PubMed ID: 15340050
-
Developmental changes of Ni(2+) sensitivity and automaticity in Nkx2.5-positive cardiac precursor cells from murine embryonic stem cell.
Manabe K, Miake J, Sasaki N, Furuichi H, Yano S, Mizuta E, Yamamoto Y, Hoshikawa Y, Yamazaki H, Tajima F, Shiota G, Nanba E, Ohgi S, Hidaka K, Morisaki T, Kurata Y, Lee JK, Igawa O, Shigemasa C, Hisatome I
Circ J. 2004
PubMed ID: 15226643
-
Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1.
Ponticos M, Partridge T, Black CM, Abraham DJ, Bou-Gharios G
Mol Cell Biol. 2004
PubMed ID: 15226419
-
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.
Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA, Baldini A
Development. 2004
PubMed ID: 15175244
-
Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death.
Huang F, Wagner M, Siddiqui MA
Mech Dev. 2004
PubMed ID: 15172687
-
Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality.
Parlakian A, Tuil D, Hamard G, Tavernier G, Hentzen D, Concordet JP, Paulin D, Li Z, Daegelen D
Mol Cell Biol. 2004
PubMed ID: 15169892
-
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.
Lincoln J, Alfieri CM, Yutzey KE
Dev Dyn. 2004
PubMed ID: 15162503
-
Novel NKX2-5 mutations in diseased heart tissues of patients with cardiac malformations.
Reamon-Buettner SM, Hecker H, Spanel-Borowski K, Craatz S, Kuenzel E, Borlak J
Am J Pathol. 2004
PubMed ID: 15161646
-
Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart.
Togi K, Kawamoto T, Yamauchi R, Yoshida Y, Kita T, Tanaka M
Mol Cell Biol. 2004
PubMed ID: 15143159
-
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis.
Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, Chen Z, Yang Z, Schneider MD, Chien KR, Conway SJ, Yoder MC, Haneline LS, Franco D, Shou W
Development. 2004
PubMed ID: 15073151
-
Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.
Pashmforoush M, Lu JT, Chen H, Amand TS, Kondo R, Pradervand S, Evans SM, Clark B, Feramisco JR, Giles W, Ho SY, Benson DW, Silberbach M, Shou W, Chien KR
Cell. 2004
PubMed ID: 15109497
-
Differential expression and function of Tbx5 and Tbx20 in cardiac development.
Plageman TF, Yutzey KE
J Biol Chem. 2004
PubMed ID: 14978031
-
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system.
Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O'Brien TX, Gourdie RG, Berul CI, Izumo S
J Clin Invest. 2004
PubMed ID: 15085192
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling.
Liu W, Selever J, Wang D, Lu MF, Moses KA, Schwartz RJ, Martin JF
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15070745
-
The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.
Brown CO, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ
J Biol Chem. 2004
PubMed ID: 14662776
-
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein.
Tetzlaff MT, Yu W, Li M, Zhang P, Finegold M, Mahon K, Harper JW, Schwartz RJ, Elledge SJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14766969
-
Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse.
Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA
Dev Biol. 2004
PubMed ID: 14975726
-
Development gone awry: congenital heart disease.
Gruber PJ, Epstein JA
Circ Res. 2004
PubMed ID: 14976138
-
Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling.
Witt CC, Ono Y, Puschmann E, McNabb M, Wu Y, Gotthardt M, Witt SH, Haak M, Labeit D, Gregorio CC, Sorimachi H, Granzier H, Labeit S
J Mol Biol. 2004
PubMed ID: 14741210
-
A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5.
Akazawa H, Kudoh S, Mochizuki N, Takekoshi N, Takano H, Nagai T, Komuro I
J Cell Biol. 2004
PubMed ID: 14757752
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis.
Ueyama T, Kasahara H, Ishiwata T, Nie Q, Izumo S
Mol Cell Biol. 2003
PubMed ID: 14645532
-
Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis.
Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu PH, Evans S, Chen J
Development. 2003
PubMed ID: 14573518
-
Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.
Naito AT, Tominaga A, Oyamada M, Oyamada Y, Shiraishi I, Monzen K, Komuro I, Takamatsu T
Exp Cell Res. 2003
PubMed ID: 14597408
-
NKX2.5 mutations in patients with congenital heart disease.
McElhinney DB, Geiger E, Blinder J, Benson DW, Goldmuntz E
J Am Coll Cardiol. 2003
PubMed ID: 14607454
-
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.
Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP
Dev Biol. 2003
PubMed ID: 14550786
-
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Umans L, Vermeire L, Francis A, Chang H, Huylebroeck D, Zwijsen A
Genesis. 2003
PubMed ID: 14502571
-
The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2).
Nagel S, Kaufmann M, Drexler HG, MacLeod RA
Cancer Res. 2003
PubMed ID: 14500364
-
Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5.
Funke-Kaiser H, Lemmer J, Langsdorff CV, Thomas A, Kovacevic SD, Strasdat M, Behrouzi T, Zollmann FS, Paul M, Orzechowski HD
FASEB J. 2003
PubMed ID: 12824294
-
The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors.
Dentice M, Morisco C, Vitale M, Rossi G, Fenzi G, Salvatore D
Mol Endocrinol. 2003
PubMed ID: 12775767
-
Csm, a cardiac-specific isoform of the RNA helicase Mov10l1, is regulated by Nkx2.5 in embryonic heart.
Ueyama T, Kasahara H, Ishiwata T, Yamasaki N, Izumo S
J Biol Chem. 2003
PubMed ID: 12754203
-
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.
Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D
Nature. 2003
PubMed ID: 12845333
-
Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes.
Iijima Y, Nagai T, Mizukami M, Matsuura K, Ogura T, Wada H, Toko H, Akazawa H, Takano H, Nakaya H, Komuro I
FASEB J. 2003
PubMed ID: 12738802
-
PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.
Ganga M, Espinoza HM, Cox CJ, Morton L, Hjalt TA, Lee Y, Amendt BA
J Biol Chem. 2003
PubMed ID: 12692125
-
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome.
Elliott DA, Kirk EP, Yeoh T, Chandar S, McKenzie F, Taylor P, Grossfeld P, Fatkin D, Jones O, Hayes P, Feneley M, Harvey RP
J Am Coll Cardiol. 2003
PubMed ID: 12798584
-
Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes.
Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, Kudoh S, Kuro-o M, Nabeshima Y, Shigekawa M, Imai Y, Komuro I
Comp Biochem Physiol B Biochem Mol Biol. 2003
PubMed ID: 12781968
-
Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity.
Chi X, Zhang SX, Yu W, DeMayo FJ, Rosenberg SM, Schwartz RJ
Genesis. 2003
PubMed ID: 12717733
-
The developing heart and congenital heart defects: a make or break situation.
Bruneau BG
Clin Genet. 2003
PubMed ID: 12702154
-
Functional analysis of TBX5 missense mutations associated with Holt-Oram syndrome.
Fan C, Liu M, Wang Q
J Biol Chem. 2003
PubMed ID: 12499378
-
Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.
Nemer G, Nemer M
Dev Biol. 2003
PubMed ID: 12606287
-
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.
Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H
Development. 2003
PubMed ID: 12490556
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis.
Smart N, Hill AA, Cross JC, Riley PR
Mech Dev. 2002
PubMed ID: 14516662
-
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.
Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G
Mech Dev. 2002
PubMed ID: 12464436
-
Two novel frameshift mutations in NKX2.5 result in novel features including visceral inversus and sinus venosus type ASD.
Watanabe Y, Benson DW, Yano S, Akagi T, Yoshino M, Murray JC
J Med Genet. 2002
PubMed ID: 12414819
-
The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene.
Thattaliyath BD, Firulli BA, Firulli AB
J Mol Cell Cardiol. 2002
PubMed ID: 12392994
-
A genetic link between Tbx1 and fibroblast growth factor signaling.
Vitelli F, Taddei I, Morishima M, Meyers EN, Lindsay EA, Baldini A
Development. 2002
PubMed ID: 12223416
-
Hop is an unusual homeobox gene that modulates cardiac development.
Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, Mullins MC, Epstein JA
Cell. 2002
PubMed ID: 12297045
-
Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling.
Aubin J, Déry U, Lemieux M, Chailler P, Jeannotte L
Development. 2002
PubMed ID: 12163410
-
The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.
Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12149478
-
Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
Lickert H, Kutsch S, Kanzler B, Tamai Y, Taketo MM, Kemler R
Dev Cell. 2002
PubMed ID: 12194849
-
The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family.
Yu TS, Moctezuma-Anaya M, Kubo A, Keller G, Robertson S
Mech Dev. 2002
PubMed ID: 12128222
-
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo.
Hart AH, Hartley L, Sourris K, Stadler ES, Li R, Stanley EG, Tam PP, Elefanty AG, Robb L
Development. 2002
PubMed ID: 12117810
-
Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart.
Toko H, Zhu W, Takimoto E, Shiojima I, Hiroi Y, Zou Y, Oka T, Akazawa H, Mizukami M, Sakamoto M, Terasaki F, Kitaura Y, Takano H, Nagai T, Nagai R, Komuro I
J Biol Chem. 2002
PubMed ID: 11889119
-
The Polycomb-group gene Rae28 sustains Nkx2.5/Csx expression and is essential for cardiac morphogenesis.
Shirai M, Osugi T, Koga H, Kaji Y, Takimoto E, Komuro I, Hara J, Miwa T, Yamauchi-Takihara K, Takihara Y
J Clin Invest. 2002
PubMed ID: 12122109
-
Progressive AV-block and anomalous venous return among cardiac anomalies associated with two novel missense mutations in the CSX/NKX2-5 gene.
Gutierrez-Roelens I, Sluysmans T, Gewillig M, Devriendt K, Vikkula M
Hum Mutat. 2002
PubMed ID: 12112663
-
Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease.
Ikeda Y, Hiroi Y, Hosoda T, Utsunomiya T, Matsuo S, Ito T, Inoue J, Sumiyoshi T, Takano H, Nagai R, Komuro I
Circ J. 2002
PubMed ID: 12074273
-
Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.
Habets PE, Moorman AF, Clout DE, van Roon MA, Lingbeek M, van Lohuizen M, Campione M, Christoffels VM
Genes Dev. 2002
PubMed ID: 12023302
-
Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis.
Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D
Nat Genet. 2002
PubMed ID: 11923873
-
Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site.
Lien CL, McAnally J, Richardson JA, Olson EN
Dev Biol. 2002
PubMed ID: 11944935
-
Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region.
Liberatore CM, Searcy-Schrick RD, Vincent EB, Yutzey KE
Dev Biol. 2002
PubMed ID: 11944934
-
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ
Development. 2002
PubMed ID: 11923206
-
Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3.
Gaussin V, Van de Putte T, Mishina Y, Hanks MC, Zwijsen A, Huylebroeck D, Behringer RR, Schneider MD
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11854453
-
Quaking is essential for blood vessel development.
Noveroske JK, Lai L, Gaussin V, Northrop JL, Nakamura H, Hirschi KK, Justice MJ
Genesis. 2002
PubMed ID: 11892011
-
Wherefore heart thou? Embryonic origins of cardiogenic mesoderm.
Yutzey KE, Kirby ML
Dev Dyn. 2002
PubMed ID: 11891982
-
A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5.
Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S
Cold Spring Harb Symp Quant Biol. 2002
PubMed ID: 12858555
-
Molecular mechanisms of ventricular hypoplasia.
Srivastava D, Gottlieb PD, Olson EN
Cold Spring Harb Symp Quant Biol. 2002
PubMed ID: 12858532
-
Homeodomain factor Nkx2-5 in heart development and disease.
Harvey RP, Lai D, Elliott D, Biben C, Solloway M, Prall O, Stennard F, Schindeler A, Groves N, Lavulo L, Hyun C, Yeoh T, Costa M, Furtado M, Kirk E
Cold Spring Harb Symp Quant Biol. 2002
PubMed ID: 12858530
-
Regulation of cardiac growth and development by SRF and its cofactors.
Wang D, Passier R, Liu ZP, Shin CH, Wang Z, Li S, Sutherland LB, Small E, Krieg PA, Olson EN
Cold Spring Harb Symp Quant Biol. 2002
PubMed ID: 12858529
-
Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.
Stanley EG, Biben C, Elefanty A, Barnett L, Koentgen F, Robb L, Harvey RP
Int J Dev Biol. 2002
PubMed ID: 12141429
-
NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis.
Biben C, Wang CC, Harvey RP
Int J Dev Biol. 2002
PubMed ID: 12141427
-
Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice.
Moses KA, DeMayo F, Braun RM, Reecy JL, Schwartz RJ
Genesis. 2001
PubMed ID: 11783008
-
NKX2.5 mutations in patients with tetralogy of fallot.
Goldmuntz E, Geiger E, Benson DW
Circulation. 2001
PubMed ID: 11714651
-
The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.
Yamagishi H, Yamagishi C, Nakagawa O, Harvey RP, Olson EN, Srivastava D
Dev Biol. 2001
PubMed ID: 11784028
-
An enhancer sequence directs LacZ expression to developing pharyngeal endoderm in transgenic mice.
Parmar H, Coletta PL, Faruque N, Sharpe PT
Genesis. 2001
PubMed ID: 11668679
-
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.
Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG
Cell. 2001
PubMed ID: 11572777
-
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node.
Zhang XM, Ramalho-Santos M, McMahon AP
Cell. 2001
PubMed ID: 11517919
-
Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein.
Kasahara H, Wakimoto H, Liu M, Maguire CT, Converso KL, Shioi T, Huang WY, Manning WJ, Paul D, Lawitts J, Berul CI, Izumo S
J Clin Invest. 2001
PubMed ID: 11457872
-
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation.
Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I
Nat Genet. 2001
PubMed ID: 11431700
-
Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx.
Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S
Mol Cell Biol. 2001
PubMed ID: 11390666
-
Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node.
Zhang XM, Ramalho-Santos M, McMahon AP
Cell. 2001
PubMed ID: 11440720
-
Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development.
Briegel KJ, Joyner AL
Dev Biol. 2001
PubMed ID: 11336496
-
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse.
Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dollé P
Development. 2001
PubMed ID: 11245568
-
Pitx2 expression defines a left cardiac lineage of cells: evidence for atrial and ventricular molecular isomerism in the iv/iv mice.
Campione M, Ros MA, Icardo JM, Piedra E, Christoffels VM, Schweickert A, Blum M, Franco D, Moorman AF
Dev Biol. 2001
PubMed ID: 11180966
-
Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein.
Kasahara H, Usheva A, Ueyama T, Aoki H, Horikoshi N, Izumo S
J Biol Chem. 2001
PubMed ID: 11042197
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5.
Biben C, Weber R, Kesteven S, Stanley E, McDonald L, Elliott DA, Barnett L, Köentgen F, Robb L, Feneley M, Harvey RP
Circ Res. 2000
PubMed ID: 11073884
-
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.
Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I
J Biol Chem. 2000
PubMed ID: 10948187
-
Xnkx-2.1: a homeobox gene expressed during early forebrain, lung and thyroid development in Xenopus laevis.
Hollemann T, Pieler T
Dev Genes Evol. 2000
PubMed ID: 11180810
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Regulation of the tinman homologues in Xenopus embryos.
Sparrow DB, Cai C, Kotecha S, Latinkic B, Cooper B, Towers N, Evans SM, Mohun TJ
Dev Biol. 2000
PubMed ID: 11076677
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.
Christoffels VM, Keijser AG, Houweling AC, Clout DE, Moorman AF
Dev Biol. 2000
PubMed ID: 10926765
-
Chamber formation and morphogenesis in the developing mammalian heart.
Christoffels VM, Habets PE, Franco D, Campione M, de Jong F, Lamers WH, Bao ZZ, Palmer S, Biben C, Harvey RP, Moorman AF
Dev Biol. 2000
PubMed ID: 10882515
-
Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease.
Kasahara H, Lee B, Schott JJ, Benson DW, Seidman JG, Seidman CE, Izumo S
J Clin Invest. 2000
PubMed ID: 10903346
-
A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2.
Svensson EC, Huggins GS, Lin H, Clendenin C, Jiang F, Tufts R, Dardik FB, Leiden JM
Nat Genet. 2000
PubMed ID: 10888889
-
Ventricular expression of tbx5 inhibits normal heart chamber development.
Liberatore CM, Searcy-Schrick RD, Yutzey KE
Dev Biol. 2000
PubMed ID: 10864469
-
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH
Cell. 2000
PubMed ID: 10892744
-
Up-regulation of natriuretic peptides in the ventricle of Csx/Nkx2-5 transgenic mice.
Takimoto E, Mizuno T, Terasaki F, Shimoyama M, Honda H, Shiojima I, Hiroi Y, Oka T, Hayashi D, Hirai H, Kudoh S, Toko H, Kawamura K, Nagai R, Yazaki Y, Komuro I
Biochem Biophys Res Commun. 2000
PubMed ID: 10772952
-
Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting.
Tanaka M, Yamasaki N, Izumo S
Mol Cell Biol. 2000
PubMed ID: 10733590
-
Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.
Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE
Dev Biol. 2000
PubMed ID: 10625552
-
NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos.
Pabst O, Herbrand H, Takuma N, Arnold HH
Dev Genes Evol. 2000
PubMed ID: 10603087
-
Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways.
Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S, Smalls O, Johnson MC, Watson MS, Seidman JG, Seidman CE, Plowden J, Kugler JD
J Clin Invest. 1999
PubMed ID: 10587520
-
oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1.
Zoltewicz JS, Plummer NW, Lin MI, Peterson AS
Development. 1999
PubMed ID: 10529425
-
Building the heart piece by piece: modularity of cis-elements regulating Nkx2-5 transcription.
Schwartz RJ, Olson EN
Development. 1999
PubMed ID: 10477287
-
Ventricular noncompaction and distal chromosome 5q deletion.
Pauli RM, Scheib-Wixted S, Cripe L, Izumo S, Sekhon GS
Am J Med Genet. 1999
PubMed ID: 10398271
-
Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.
Komada M, Soriano P
Genes Dev. 1999
PubMed ID: 10364163
-
A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart.
Xavier-Neto J, Neville CM, Shapiro MD, Houghton L, Wang GF, Nikovits W, Stockdale FE, Rosenthal N
Development. 1999
PubMed ID: 10331979
-
The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart.
Clark TG, Conway SJ, Scott IC, Labosky PA, Winnier G, Bundy J, Hogan BL, Greenspan DS
Development. 1999
PubMed ID: 10331975
-
Transcriptional antagonism between Hmx1 and Nkx2.5 for a shared DNA-binding site.
Amendt BA, Sutherland LB, Russo AF
J Biol Chem. 1999
PubMed ID: 10206974
-
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.
Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A
Development. 1999
PubMed ID: 10079226
-
Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5.
Tanaka M, Wechsler SB, Lee IW, Yamasaki N, Lawitts JA, Izumo S
Development. 1999
PubMed ID: 10068637
-
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.
Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S
Development. 1999
PubMed ID: 10021345
-
Identification of upstream regulatory regions in the heart-expressed homeobox gene Nkx2-5.
Reecy JM, Li X, Yamada M, DeMayo FJ, Newman CS, Harvey RP, Schwartz RJ
Development. 1999
PubMed ID: 9895330
-
Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5.
Kasahara H, Izumo S
Mol Cell Biol. 1999
PubMed ID: 9858576
-
Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.
Lien CL, Wu C, Mercer B, Webb R, Richardson JA, Olson EN
Development. 1999
PubMed ID: 9834187
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells.
Skerjanc IS, Petropoulos H, Ridgeway AG, Wilton S
J Biol Chem. 1998
PubMed ID: 9857019
-
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.
Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB
Development. 1998
PubMed ID: 9811571
-
A GATA-dependent nkx-2.5 regulatory element activates early cardiac gene expression in transgenic mice.
Searcy RD, Vincent EB, Liberatore CM, Yutzey KE
Development. 1998
PubMed ID: 9778505
-
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.
Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y
J Biol Chem. 1998
PubMed ID: 9748262
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Congenital heart disease caused by mutations in the transcription factor NKX2-5.
Schott JJ, Benson DW, Basson CT, Pease W, Silberbach GM, Moak JP, Maron BJ, Seidman CE, Seidman JG
Science. 1998
PubMed ID: 9651244
-
A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice.
Charng MJ, Frenkel PA, Lin Q, Yamada M, Schwartz RJ, Olson EN, Overbeek P, Schneider MD, Yumada M
Dev Biol. 1998
PubMed ID: 9676193
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The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.
Lee Y, Shioi T, Kasahara H, Jobe SM, Wiese RJ, Markham BE, Izumo S
Mol Cell Biol. 1998
PubMed ID: 9584153
-
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis.
Riley P, Anson-Cartwright L, Cross JC
Nat Genet. 1998
PubMed ID: 9500551
-
Murine cerberus homologue mCer-1: a candidate anterior patterning molecule.
Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, Lah M, Wang CC, Nash A, Hilton D, Ang SL, Mohun T, Harvey RP
Dev Biol. 1998
PubMed ID: 9501024
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Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development.
Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y, Lyons GE, Izumo S
Dev Genet. 1998
PubMed ID: 9621431
-
Murine cardiac progenitor cells require visceral embryonic endoderm and primitive streak for terminal differentiation.
Arai A, Yamamoto K, Toyama J
Dev Dyn. 1997
PubMed ID: 9389458
-
Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.
Yoshiura KI, Murray JC
Genomics. 1997
PubMed ID: 9344671
-
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.
Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M
EMBO J. 1997
PubMed ID: 9312027
-
Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development.
Biben C, Harvey RP
Genes Dev. 1997
PubMed ID: 9192865
-
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.
Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN
Nat Genet. 1997
PubMed ID: 9171826
-
Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C.
Lin Q, Schwarz J, Bucana C, Olson EN
Science. 1997
PubMed ID: 9162005
-
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Molkentin JD, Lin Q, Duncan SA, Olson EN
Genes Dev. 1997
PubMed ID: 9136933
-
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM
Genes Dev. 1997
PubMed ID: 9136932
-
Identification and linkage mapping of Hst7, a new M. spretus/M. m. domesticus chromosome 17 hybrid sterility locus.
Pilder SH
Mamm Genome. 1997
PubMed ID: 9096116
-
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
Zou Y, Evans S, Chen J, Kuo HC, Harvey RP, Chien KR
Development. 1997
PubMed ID: 9043061
-
Molecular cloning and characterization of human cardiac homeobox gene CSX1.
Shiojima I, Komuro I, Mizuno T, Aikawa R, Akazawa H, Oka T, Yamazaki T, Yazaki Y
Circ Res. 1996
PubMed ID: 8888684
-
Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription.
Chen CY, Schwartz RJ
Mol Cell Biol. 1996
PubMed ID: 8887666
-
Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development.
Zhang H, Bradley A
Development. 1996
PubMed ID: 8898212
-
An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression.
Ross RS, Navankasattusas S, Harvey RP, Chien KR
Development. 1996
PubMed ID: 8674419
-
Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the NKx transcription factor family members thyroid transciption factor 1 and cardiac muscle-specific homeobox protein (CSX).
Ray MK, Chen CY, Schwartz RJ, DeMayo FJ
Mol Cell Biol. 1996
PubMed ID: 8628271
-
Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx.
Turbay D, Wechsler SB, Blanchard KM, Izumo S
Mol Med. 1996
PubMed ID: 8900537
-
Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements.
Chen CY, Croissant J, Majesky M, Topouzis S, McQuinn T, Frankovsky MJ, Schwartz RJ
Dev Genet. 1996
PubMed ID: 8900044
-
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP
Genes Dev. 1995
PubMed ID: 7628699
-
Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5.
Chen CY, Schwartz RJ
J Biol Chem. 1995
PubMed ID: 7797561
-
Assignment of cardiac homeobox gene CSX to human chromosome 5q34.
Shiojima I, Komuro I, Inazawa J, Nakahori Y, Matsushita I, Abe T, Nagai R, Yazaki Y
Genomics. 1995
PubMed ID: 7665173
-
High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci.
Himmelbauer H, Harvey RP, Copeland NG, Jenkins NA, Silver LM
Mamm Genome. 1994
PubMed ID: 7894168
-
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP
Development. 1993
PubMed ID: 7910553
-
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP
Development. 1993
PubMed ID: 7904557
-
Csx: a murine homeobox-containing gene specifically expressed in the developing heart.
Komuro I, Izumo S
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7690144
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