Home TICAM1
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(Human) GRCh37 - chr19:4815938..4831737 (15.80 kb) View in Genome Browser
(Mouse) NCBIM37 - chr17:56408742..56416209 (7.47 kb) View in Genome Browser
HaemAtlas Expression Table for TICAM1:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | no data | no data | no data | ||||||||
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for TICAM1:The TICAM1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| TICAM1 | RIPK3 | HPRD, BioGRID | empirical | 15064760 |
| TICAM1 | TIRAP | HPRD | empirical | 14517278 |
| TICAM1 | TRAM1 | HPRD | empirical | 12721283 |
| TICAM1 | TBK1 | HPRD, IntAct, BioGRID | empirical | 14530355 15841462 21441935 21903422 |
| TICAM1 | TICAM2 | HPRD, IntAct | empirical | 14519765 12721283 |
| TICAM1 | IRF3 | HPRD | empirical | 14739303 |
| TICAM1 | IRF7 | HPRD | empirical | 14739303 |
| TICAM1 | PIAS4 | HPRD, MINT | empirical | 15251447 |
| TICAM1 | PIK3CA | HPRD | empirical | 15940673 |
| TICAM1 | RNF216 | BioGRID | empirical | 16968706 |
| TICAM1 | MAVS | HPRD | empirical | 16153868 |
| TICAM1 | SRSF4 | IntAct | empirical | 21988832 |
| TICAM1 | AZI2 | HPRD | empirical | 15611223 |
| TICAM1 | SYK | IntAct | empirical | 20639876 |
| TICAM1 | BTK | IntAct | empirical | 21441935 |
| TICAM1 | TLR2 | HPRD | empirical | 12471095 |
| TICAM1 | TLR3 | HPRD | empirical | 12539043 14982987 |
| TICAM1 | TLR4 | BioGRID | empirical | 19898473 |
| TICAM1 | TNFAIP3 | HPRD, MINT | empirical | 15474016 |
| TICAM1 | TRAF1 | HPRD | empirical | 16323247 |
| TICAM1 | TRAF3 | HPRD, BioGRID | empirical | 16306936 16306937 17991829 19898473 |
| TICAM1 | TRAF6 | HPRD, BioGRID | empirical | 14530355 14982987 20047764 19898473 |
| TICAM1 | UBC | BioGRID | empirical | 20047764 21906983 |
| TICAM1 | CBLB | IntAct | empirical | 20639876 |
| TICAM1 | RIPK1 | HPRD, BioGRID | empirical | 15064760 19734906 |
| TICAM1 | TRAF4 | HPRD | empirical | 16052631 |
| TICAM1 | IKBKE | HPRD | empirical | 12692549 |
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Type 1 Diabetes Publications: 1
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Role of the TLR signaling molecule TRIF in β-cell function and glucose homeostasis.
Hutton MJ, Soukhatcheva G, Johnson JD, Verchere CB
Islets. 2010
PubMed ID: 21099302
Publications: 362
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The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S
J Virol. 2012
PubMed ID: 22072781
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The TLR4-TRIF pathway protects against H5N1 influenza virus infection.
Shinya K, Ito M, Makino A, Tanaka M, Miyake K, Eisfeld AJ, Kawaoka Y
J Virol. 2012
PubMed ID: 22031950
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Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity.
Sotolongo J, España C, Echeverry A, Siefker D, Altman N, Zaias J, Santaolalla R, Ruiz J, Schesser K, Adkins B, Fukata M
J Exp Med. 2011
PubMed ID: 22124111
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The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis.
Popovic ZV, Wang S, Papatriantafyllou M, Kaya Z, Porubsky S, Meisner M, Bonrouhi M, Burgdorf S, Young MF, Schaefer L, Gröne HJ
J Immunol. 2011
PubMed ID: 22095710
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Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.
He S, Liang Y, Shao F, Wang X
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22123964
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Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
Sancho-Shimizu V, Pérez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL
J Clin Invest. 2011
PubMed ID: 22105173
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Ehrlichia chaffeensis induces monocyte inflammatory responses through MyD88, ERK, and NF-κB but not through TRIF, interleukin-1 receptor 1 (IL-1R1)/IL-18R1, or toll-like receptors.
Miura K, Matsuo J, Rahman MA, Kumagai Y, Li X, Rikihisa Y
Infect Immun. 2011
PubMed ID: 21930764
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Basolateral LPS inhibits NHE3 and HCOFormula absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb.
Watts BA, George T, Sherwood ER, Good DW
Am J Physiol Cell Physiol. 2011
PubMed ID: 21881005
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Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.
Mouchess ML, Arpaia N, Souza G, Barbalat R, Ewald SE, Lau L, Barton GM
Immunity. 2011
PubMed ID: 22078797
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The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T
J Immunol. 2011
PubMed ID: 21998457
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Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction.
Morgado P, Ong YC, Boothroyd JC, Lodoen MB
Infect Immun. 2011
PubMed ID: 21911468
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Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.
Semple F, MacPherson H, Webb S, Cox SL, Mallin LJ, Tyrrell C, Grimes GR, Semple CA, Nix MA, Millhauser GL, Dorin JR
Eur J Immunol. 2011
PubMed ID: 21809339
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Delineation of the role of Toll-like receptor signaling during peritonitis by a gradually growing pathogenic Escherichia coli.
van 't Veer C, van den Pangaart PS, Kruijswijk D, Florquin S, de Vos AF, van der Poll T
J Biol Chem. 2011
PubMed ID: 21690093
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The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
Clark K, Takeuchi O, Akira S, Cohen P
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21949249
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Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria.
Kinjo Y, Illarionov P, Vela JL, Pei B, Girardi E, Li X, Li Y, Imamura M, Kaneko Y, Okawara A, Miyazaki Y, Gómez-Velasco A, Rogers P, Dahesh S, Uchiyama S, Khurana A, Kawahara K, Yesilkaya H, Andrew PW, Wong CH, Kawakami K, Nizet V, Besra GS, Tsuji M, Zajonc DM, Kronenberg M
Nat Immunol. 2011
PubMed ID: 21892173
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A subclass of acylated anti-inflammatory mediators usurp Toll-like receptor 2 to inhibit neutrophil recruitment through peroxisome proliferator-activated receptor gamma.
Long EM, Klimowicz AC, Paula-Neto HA, Millen B, McCafferty DM, Kubes P, Robbins SM
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21930915
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Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Li S, Wang L, Berman M, Kong YY, Dorf ME
Immunity. 2011
PubMed ID: 21903422
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CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism.
Landrigan A, Wong MT, Utz PJ
J Immunol. 2011
PubMed ID: 21844387
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Mucosa-associated epithelial chemokine/CCL28 expression in the uterus attracts CCR10+ IgA plasma cells following mucosal vaccination via estrogen control.
Cha HR, Ko HJ, Kim ED, Chang SY, Seo SU, Cuburu N, Ryu S, Kim S, Kweon MN
J Immunol. 2011
PubMed ID: 21832166
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Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.
Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W
J Biol Chem. 2011
PubMed ID: 21775438
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Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.
Qu L, Feng Z, Yamane D, Liang Y, Lanford RE, Li K, Lemon SM
PLoS Pathog. 2011
PubMed ID: 21931545
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MyD88 and Trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis.
Feng Y, Zou L, Zhang M, Li Y, Chen C, Chao W
Anesthesiology. 2011
PubMed ID: 21792053
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Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3.
Lei X, Sun Z, Liu X, Jin Q, He B, Wang J
J Virol. 2011
PubMed ID: 21697485
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Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1α (HIF1A) and result in differential HIF1A-dependent gene expression.
Jantsch J, Wiese M, Schödel J, Castiglione K, Gläsner J, Kolbe S, Mole D, Schleicher U, Eckardt KU, Hensel M, Lang R, Bogdan C, Schnare M, Willam C
J Leukoc Biol. 2011
PubMed ID: 21685248
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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Sharma S, DeOliveira RB, Kalantari P, Parroche P, Goutagny N, Jiang Z, Chan J, Bartholomeu DC, Lauw F, Hall JP, Barber GN, Gazzinelli RT, Fitzgerald KA, Golenbock DT
Immunity. 2011
PubMed ID: 21820332
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B cells enhance early innate immune responses during bacterial sepsis.
Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL
J Exp Med. 2011
PubMed ID: 21746813
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Endotoxin-induced uveitis is primarily dependent on radiation-resistant cells and on MyD88 but not TRIF.
Kezic J, Taylor S, Gupta S, Planck SR, Rosenzweig HL, Rosenbaum JT
J Leukoc Biol. 2011
PubMed ID: 21610198
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Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling.
Delano MJ, Kelly-Scumpia KM, Thayer TC, Winfield RD, Scumpia PO, Cuenca AG, Harrington PB, O'Malley KA, Warner E, Gabrilovich S, Mathews CE, Laface D, Heyworth PG, Ramphal R, Strieter RM, Moldawer LL, Efron PA
J Immunol. 2011
PubMed ID: 21690321
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A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members.
Johnson J, Molle C, Aksoy E, Goldman M, Goriely S, Willems F
Mol Immunol. 2011
PubMed ID: 21550664
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Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis.
Gallego C, Golenbock D, Gomez MA, Saravia NG
Infect Immun. 2011
PubMed ID: 21518783
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Recognition of yeast nucleic acids triggers a host-protective type I interferon response.
Biondo C, Signorino G, Costa A, Midiri A, Gerace E, Galbo R, Bellantoni A, Malara A, Beninati C, Teti G, Mancuso G
Eur J Immunol. 2011
PubMed ID: 21480215
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Detection of prokaryotic mRNA signifies microbial viability and promotes immunity.
Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, Ryffel B, Swanson JA, Müller M, Blander JM
Nature. 2011
PubMed ID: 21602824
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CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1.
Lee SM, Kim EJ, Suk K, Lee WH
J Immunol. 2011
PubMed ID: 21536801
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The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages.
Reis J, Hassan F, Guan XQ, Shen J, Monaco JJ, Papasian CJ, Qureshi AA, Van Way CW, Vogel SN, Morrison DC, Qureshi N
Cell Biochem Biophys. 2011
PubMed ID: 21455681
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Intestinal bacterial colonization induces mutualistic regulatory T cell responses.
Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, McCoy KD, Macpherson AJ
Immunity. 2011
PubMed ID: 21596591
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TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Gaddis DE, Michalek SM, Katz J
J Immunol. 2011
PubMed ID: 21498664
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Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice.
Duggan JM, You D, Cleaver JO, Larson DT, Garza RJ, Guzmán Pruneda FA, Tuvim MJ, Zhang J, Dickey BF, Evans SE
J Immunol. 2011
PubMed ID: 21482737
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A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.
Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD
Science. 2011
PubMed ID: 21551061
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Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia.
Famakin BM, Mou Y, Ruetzler CA, Bembry J, Maric D, Hallenbeck JM
Brain Res. 2011
PubMed ID: 21376021
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Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk.
Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao H, Cao X
Nat Immunol. 2011
PubMed ID: 21441935
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Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.
Keck S, Müller I, Fejer G, Savic I, Tchaptchet S, Nielsen PJ, Galanos C, Huber M, Freudenberg MA
J Immunol. 2011
PubMed ID: 21441453
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Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis.
Tamaki Y, Takakubo Y, Hirayama T, Konttinen YT, Goodman SB, Yamakawa M, Takagi M
J Rheumatol. 2011
PubMed ID: 21324962
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Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG
J Immunol. 2011
PubMed ID: 21398616
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MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4.
Cekic C, Casella CR, Sag D, Antignano F, Kolb J, Suttles J, Hughes MR, Krystal G, Mitchell TC
J Immunol. 2011
PubMed ID: 21339365
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RIP3 mediates the embryonic lethality of caspase-8-deficient mice.
Kaiser WJ, Upton JW, Long AB, Livingston-Rosanoff D, Daley-Bauer LP, Hakem R, Caspary T, Mocarski ES
Nature. 2011
PubMed ID: 21368762
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Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice.
Lin Q, Fang D, Fang J, Ren X, Yang X, Wen F, Su SB
J Immunol. 2011
PubMed ID: 21317384
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Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing beta-interferon (TRIF).
Ahmad H, Gubbels R, Ehlers E, Meyer F, Waterbury T, Lin R, Zhang L
J Biol Chem. 2011
PubMed ID: 21212282
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Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.
Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, Stockinger S, Decker T, Akira S, Müller M, Kuchler K
J Immunol. 2011
PubMed ID: 21282509
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Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction.
Tezuka H, Abe Y, Asano J, Sato T, Liu J, Iwata M, Ohteki T
Immunity. 2011
PubMed ID: 21333555
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The role of TBK1 and IKKε in the expression and activation of Pellino 1.
Smith H, Liu XY, Dai L, Goh ET, Chan AT, Xi J, Seh CC, Qureshi IA, Lescar J, Ruedl C, Gourlay R, Morton S, Hough J, McIver EG, Cohen P, Cheung PC
Biochem J. 2011
PubMed ID: 21204785
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Differential expression of NLRP3 among hematopoietic cells.
Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, Tschopp J
J Immunol. 2011
PubMed ID: 21257968
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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-β and RANTES production.
Siednienko J, Gajanayake T, Fitzgerald KA, Moynagh P, Miggin SM
J Immunol. 2011
PubMed ID: 21248248
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TRIF is a critical survival factor in viral cardiomyopathy.
Riad A, Westermann D, Zietsch C, Savvatis K, Becher PM, Bereswill S, Heimesaat MM, Lettau O, Lassner D, Dörner A, Poller W, Busch M, Felix SB, Schultheiss HP, Tschöpe C
J Immunol. 2011
PubMed ID: 21239721
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Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A.
Molenaar R, Knippenberg M, Goverse G, Olivier BJ, de Vos AF, O'Toole T, Mebius RE
J Immunol. 2011
PubMed ID: 21220692
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IL-13 suppresses double-stranded RNA-induced IFN-λ production in lung cells.
Moriwaki A, Matsumoto K, Matsunaga Y, Fukuyama S, Matsumoto T, Kan-o K, Noda N, Asai Y, Nakanishi Y, Inoue H
Biochem Biophys Res Commun. 2011
PubMed ID: 21184733
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Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways.
Yu M, Lam J, Rada B, Leto TL, Levine SJ
J Immunol. 2011
PubMed ID: 21148036
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A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.
Sweeney TE, Suliman HB, Hollingsworth JW, Welty-Wolf KE, Piantadosi CA
PLoS One. 2011
PubMed ID: 21966468
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MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection.
de Almeida LA, Carvalho NB, Oliveira FS, Lacerda TL, Vasconcelos AC, Nogueira L, Bafica A, Silva AM, Oliveira SC
PLoS One. 2011
PubMed ID: 21829705
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Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice.
Reino DC, Pisarenko V, Palange D, Doucet D, Bonitz RP, Lu Q, Colorado I, Sheth SU, Chandler B, Kannan KB, Ramanathan M, Xu da Z, Deitch EA, Feinman R
PLoS One. 2011
PubMed ID: 21829592
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TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.
Seregin SS, Aldhamen YA, Appledorn DM, Aylsworth CF, Godbehere S, Liu CJ, Quiroga D, Amalfitano A
PLoS One. 2011
PubMed ID: 21760953
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Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection.
Shimada K, Crother TR, Karlin J, Chen S, Chiba N, Ramanujan VK, Vergnes L, Ojcius DM, Arditi M
PLoS One. 2011
PubMed ID: 21731762
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Novel murine infection models provide deep insights into the "ménage à trois" of Campylobacter jejuni, microbiota and host innate immunity.
Bereswill S, Fischer A, Plickert R, Haag LM, Otto B, Kühl AA, Dasti JI, Dashti JI, Zautner AE, Muñoz M, Loddenkemper C, Gross U, Göbel UB, Heimesaat MM
PLoS One. 2011
PubMed ID: 21698299
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The ubiquitin-like protein PLIC-1 or ubiquilin 1 inhibits TLR3-Trif signaling.
Biswas N, Liu S, Ronni T, Aussenberg SE, Liu W, Fujita T, Wang T
PLoS One. 2011
PubMed ID: 21695056
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Graft-versus-host disease is independent of innate signaling pathways triggered by pathogens in host hematopoietic cells.
Li H, Matte-Martone C, Tan HS, Venkatesan S, McNiff J, Demetris AJ, Jain D, Lakkis F, Rothstein D, Shlomchik WD
J Immunol. 2011
PubMed ID: 21098219
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Production of IFN-γ by CD4(+) T cells in response to malaria antigens is IL-2 dependent.
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Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells.
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Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.
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TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells.
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Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
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J Exp Med. 2010
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Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
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Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells.
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Proc Natl Acad Sci U S A. 2010
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MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands.
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Proc Natl Acad Sci U S A. 2010
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Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
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TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM
Eur J Immunol. 2010
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IFI16 is an innate immune sensor for intracellular DNA.
Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG
Nat Immunol. 2010
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Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, Li Y, Hu X, Ivashkiv LB
J Immunol. 2010
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Synergy between viral and bacterial toll-like receptors leads to amplification of inflammatory responses and preterm labor in the mouse.
Ilievski V, Hirsch E
Biol Reprod. 2010
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Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
Eur J Hum Genet. 2010
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Intravascular danger signals guide neutrophils to sites of sterile inflammation.
McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CC, Beck PL, Muruve DA, Kubes P
Science. 2010
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TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.
Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E
J Immunol. 2010
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Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury.
Feng Y, Zou L, Si R, Nagasaka Y, Chao W
Am J Physiol Cell Physiol. 2010
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Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice.
Smith LS, Gharib SA, Frevert CW, Martin TR
Am J Respir Cell Mol Biol. 2010
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IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice.
Carrigan SO, Junkins R, Yang YJ, Macneil A, Richardson C, Johnston B, Lin TJ
J Immunol. 2010
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TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica.
Barr TA, Brown S, Mastroeni P, Gray D
J Immunol. 2010
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TLR-mediated loss of CD62L focuses B cell traffic to the spleen during Salmonella typhimurium infection.
Morrison VL, Barr TA, Brown S, Gray D
J Immunol. 2010
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Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways.
Zhan Y, Xu Y, Seah S, Brady JL, Carrington EM, Cheers C, Croker BA, Wu L, Villadangos JA, Lew AM
J Immunol. 2010
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Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.
Han C, Jin J, Xu S, Liu H, Li N, Cao X
Nat Immunol. 2010
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A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Anthony DA, Andrews DM, Chow M, Watt SV, House C, Akira S, Bird PI, Trapani JA, Smyth MJ
J Immunol. 2010
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Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus.
Buchholz BM, Billiar TR, Bauer AJ
Am J Physiol Gastrointest Liver Physiol. 2010
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TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5.
Choi YJ, Im E, Pothoulakis C, Rhee SH
J Biol Chem. 2010
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Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.
Torres D, Dieudonné A, Ryffel B, Vilain E, Si-Tahar M, Pichavant M, Lassalle P, Trottein F, Gosset P
J Immunol. 2010
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The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
Tang H, Cao W, Kasturi SP, Ravindran R, Nakaya HI, Kundu K, Murthy N, Kepler TB, Malissen B, Pulendran B
Nat Immunol. 2010
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Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D
Hum Immunol. 2010
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The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes.
Miller JC, Maylor-Hagen H, Ma Y, Weis JH, Weis JJ
Infect Immun. 2010
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Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy.
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J Leukoc Biol. 2010
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A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.
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J Biol Chem. 2010
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Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation.
Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS, Fessler MB
Cell Metab. 2010
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ERK activation drives intestinal tumorigenesis in Apc(min/+) mice.
Lee SH, Hu LL, Gonzalez-Navajas J, Seo GS, Shen C, Brick J, Herdman S, Varki N, Corr M, Lee J, Raz E
Nat Med. 2010
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Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria.
Belyaev NN, Brown DE, Diaz AI, Rae A, Jarra W, Thompson J, Langhorne J, Potocnik AJ
Nat Immunol. 2010
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SARM inhibits both TRIF- and MyD88-mediated AP-1 activation.
Peng J, Yuan Q, Lin B, Panneerselvam P, Wang X, Luan XL, Lim SK, Leung BP, Ho B, Ding JL
Eur J Immunol. 2010
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TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2.
Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B
J Immunol. 2010
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Memory CD4+ T cells induce innate responses independently of pathogen.
Strutt TM, McKinstry KK, Dibble JP, Winchell C, Kuang Y, Curtis JD, Huston G, Dutton RW, Swain SL
Nat Med. 2010
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Risk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20406964
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TLR4 is a negative regulator in noninfectious lung inflammation.
Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA
J Immunol. 2010
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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.
Martinon F, Chen X, Lee AH, Glimcher LH
Nat Immunol. 2010
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Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Núñez G, Suzuki T
J Immunol. 2010
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Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells.
Liu Y, Xiang X, Zhuang X, Zhang S, Liu C, Cheng Z, Michalek S, Grizzle W, Zhang HG
Am J Pathol. 2010
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Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
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Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.
Wang L, Gordon RA, Huynh L, Su X, Park Min KH, Han J, Arthur JS, Kalliolias GD, Ivashkiv LB
Immunity. 2010
PubMed ID: 20362473
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Analysis of a TIR-less splice variant of TRIF reveals an unexpected mechanism of TLR3-mediated signaling.
Han KJ, Yang Y, Xu LG, Shu HB
J Biol Chem. 2010
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Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.
Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A
J Immunol. 2010
PubMed ID: 20200276
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Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells.
Guilliams M, Crozat K, Henri S, Tamoutounour S, Grenot P, Devilard E, de Bovis B, Alexopoulou L, Dalod M, Malissen B
Blood. 2010
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TAK1 targeting by glucocorticoids determines JNK and IkappaB regulation in Toll-like receptor-stimulated macrophages.
Bhattacharyya S, Ratajczak CK, Vogt SK, Kelley C, Colonna M, Schreiber RD, Muglia LJ
Blood. 2010
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An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses.
DeWitte-Orr SJ, Collins SE, Bauer CM, Bowdish DM, Mossman KL
PLoS Pathog. 2010
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Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling.
Scumpia PO, Kelly-Scumpia KM, Delano MJ, Weinstein JS, Cuenca AG, Al-Quran S, Bovio I, Akira S, Kumagai Y, Moldawer LL
J Immunol. 2010
PubMed ID: 20130216
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Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo.
Davey GM, Wojtasiak M, Proietto AI, Carbone FR, Heath WR, Bedoui S
J Immunol. 2010
PubMed ID: 20124105
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Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.
Prantner D, Darville T, Nagarajan UM
J Immunol. 2010
PubMed ID: 20107183
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Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.
Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T
Mol Immunol. 2010
PubMed ID: 20047764
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Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process.
Molle C, Goldman M, Goriely S
J Immunol. 2010
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TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice.
González-Navajas JM, Fine S, Law J, Datta SK, Nguyen KP, Yu M, Corr M, Katakura K, Eckman L, Lee J, Raz E
J Clin Invest. 2010
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TLR2-dependent inflammatory response to Porphyromonas gingivalis is MyD88 independent, whereas MyD88 is required to clear infection.
Burns E, Eliyahu T, Uematsu S, Akira S, Nussbaum G
J Immunol. 2010
PubMed ID: 20042569
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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, Khoury JE, Golenbock DT, Moore KJ
Nat Immunol. 2010
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PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells.
Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E, Willems F
Eur J Immunol. 2010
PubMed ID: 19950169
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IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells.
Kubota N, Ebihara T, Matsumoto M, Gando S, Seya T
Biochem Biophys Res Commun. 2010
PubMed ID: 20026056
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Differential effect of TLR2 and TLR4 on the immune response after immunization with a vaccine against Neisseria meningitidis or Bordetella pertussis.
Fransen F, Stenger RM, Poelen MC, van Dijken HH, Kuipers B, Boog CJ, van Putten JP, van Els CA, van der Ley P
PLoS One. 2010
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Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.
Yadav M, Zhang J, Fischer H, Huang W, Lutay N, Cirl C, Lum J, Miethke T, Svanborg C
PLoS Pathog. 2010
PubMed ID: 20886104
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UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
Melo MB, Kasperkovitz P, Cerny A, Könen-Waisman S, Kurt-Jones EA, Lien E, Beutler B, Howard JC, Golenbock DT, Gazzinelli RT
PLoS Pathog. 2010
PubMed ID: 20865117
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Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis.
Leal SM, Cowden S, Hsia YC, Ghannoum MA, Momany M, Pearlman E
PLoS Pathog. 2010
PubMed ID: 20617171
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Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M
Nat Immunol. 2010
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The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice.
Hua F, Wang J, Sayeed I, Ishrat T, Atif F, Stein DG
Biochem Biophys Res Commun. 2009
PubMed ID: 19825364
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Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
Talbot S, Tötemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE
Immunology. 2009
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Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.
Takaki H, Oshiumi H, Sasai M, Kawanishi T, Matsumoto M, Seya T
Eur J Immunol. 2009
PubMed ID: 19795416
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Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS.
Muto J, Yamasaki K, Taylor KR, Gallo RL
Mol Immunol. 2009
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Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection.
Cai S, Batra S, Shen L, Wakamatsu N, Jeyaseelan S
J Immunol. 2009
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Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance.
Deng ZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S, Zhuang X, Shah SV, Sun D, Michalek S, Grizzle WE, Garvey T, Mobley J, Zhang HG
Diabetes. 2009
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Mechanical ventilation induces a Toll/interleukin-1 receptor domain-containing adapter-inducing interferon beta-dependent inflammatory response in healthy mice.
Vaneker M, Heunks LM, Joosten LA, van Hees HW, Snijdelaar DG, Halbertsma FJ, van Egmond J, Netea MG, van der Hoeven JG, Scheffer GJ
Anesthesiology. 2009
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Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production.
Chang M, Jin W, Sun SC
Nat Immunol. 2009
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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE
J Leukoc Biol. 2009
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TLR4-mediated Cox-2 expression increases intestinal ischemia/reperfusion-induced damage.
Moses T, Wagner L, Fleming SD
J Leukoc Biol. 2009
PubMed ID: 19564573
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Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease.
Kovalenko A, Kim JC, Kang TB, Rajput A, Bogdanov K, Dittrich-Breiholz O, Kracht M, Brenner O, Wallach D
J Exp Med. 2009
PubMed ID: 19720838
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A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.
Muñoz-Planillo R, Franchi L, Miller LS, Núñez G
J Immunol. 2009
PubMed ID: 19717510
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Signaling events leading to peroxiredoxin 5 up-regulation in immunostimulated macrophages.
Abbas K, Breton J, Picot CR, Quesniaux V, Bouton C, Drapier JC
Free Radic Biol Med. 2009
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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
McWhirter SM, Barbalat R, Monroe KM, Fontana MF, Hyodo M, Joncker NT, Ishii KJ, Akira S, Colonna M, Chen ZJ, Fitzgerald KA, Hayakawa Y, Vance RE
J Exp Med. 2009
PubMed ID: 19652017
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IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity.
Pletneva M, Fan H, Park JJ, Radojcic V, Jie C, Yu Y, Chan C, Redwood A, Pardoll D, Housseau F
Cancer Res. 2009
PubMed ID: 19679552
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Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways.
Miyake T, Kumagai Y, Kato H, Guo Z, Matsushita K, Satoh T, Kawagoe T, Kumar H, Jang MH, Kawai T, Tani T, Takeuchi O, Akira S
J Immunol. 2009
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Leukotriene B4 potentiates CpG signaling for enhanced cytokine secretion by human leukocytes.
Gaudreault E, Gosselin J
J Immunol. 2009
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The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1).
Steinfelder S, Andersen JF, Cannons JL, Feng CG, Joshi M, Dwyer D, Caspar P, Schwartzberg PL, Sher A, Jankovic D
J Exp Med. 2009
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Selective expansion of the monocytic lineage directed by bacterial infection.
Serbina NV, Hohl TM, Cherny M, Pamer EG
J Immunol. 2009
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DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
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The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice.
Zhu J, Huang X, Yang Y
J Clin Invest. 2009
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Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism.
Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, Geuking MB, Beutler B, Tedder TF, Hardt WD, Bercik P, Verdu EF, McCoy KD, Macpherson AJ
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Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.
Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh YT, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler BA, Theofilopoulos AN
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19574451
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Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
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A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J Immunol. 2009
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NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K
PLoS Pathog. 2009
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Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.
Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT
J Immunol. 2009
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Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF).
Brzezinska AA, Johnson JL, Munafo DB, Ellis BA, Catz SD
Immunology. 2009
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NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.
Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS, Beutler B, Janssen E, Hoebe K
Blood. 2009
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Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S, Uematsu S, Didierlaurent A, Hussell T, Ryffel B, Erard F
Eur J Immunol. 2009
PubMed ID: 19424969
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Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes.
Rathinam VA, Appledorn DM, Hoag KA, Amalfitano A, Mansfield LS
Infect Immun. 2009
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The adaptor molecule MyD88 directly promotes CD8 T cell responses to vaccinia virus.
Zhao Y, De Trez C, Flynn R, Ware CF, Croft M, Salek-Ardakani S
J Immunol. 2009
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Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19423540
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Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF.
McAleer JP, Rossi RJ, Vella AT
J Immunol. 2009
PubMed ID: 19380779
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Lipocalin 2 is required for pulmonary host defense against Klebsiella infection.
Chan YR, Liu JS, Pociask DA, Zheng M, Mietzner TA, Berger T, Mak TW, Clifton MC, Strong RK, Ray P, Kolls JK
J Immunol. 2009
PubMed ID: 19342674
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Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
Kumagai Y, Kumar H, Koyama S, Kawai T, Takeuchi O, Akira S
J Immunol. 2009
PubMed ID: 19299691
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Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.
Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ
Am J Physiol Renal Physiol. 2009
PubMed ID: 19158348
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Hepatic interleukin-7 expression regulates T cell responses.
Sawa Y, Arima Y, Ogura H, Kitabayashi C, Jiang JJ, Fukushima T, Kamimura D, Hirano T, Murakami M
Immunity. 2009
PubMed ID: 19285437
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Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation.
Torchinsky MB, Garaude J, Martin AP, Blander JM
Nature. 2009
PubMed ID: 19262671
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Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells.
Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, Niiro H, Harada M, Tanimoto M, Akashi K, Teshima T
Blood. 2009
PubMed ID: 19144988
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Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway.
Kim JH, Kim SJ, Lee IS, Lee MS, Uematsu S, Akira S, Oh KI
J Immunol. 2009
PubMed ID: 19201901
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Innate immunity mediated by MyD88 signal is not essential for induction of lipopolysaccharide-specific B cell responses but is indispensable for protection against Salmonella enterica serovar Typhimurium infection.
Ko HJ, Yang JY, Shim DH, Yang H, Park SM, Curtiss R, Kweon MN
J Immunol. 2009
PubMed ID: 19201885
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TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
Miyahira AK, Shahangian A, Hwang S, Sun R, Cheng G
J Immunol. 2009
PubMed ID: 19201879
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Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction.
Bode KA, Schmitz F, Vargas L, Heeg K, Dalpke AH
J Immunol. 2009
PubMed ID: 19201871
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The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors.
McAllister CS, Samuel CE
J Biol Chem. 2009
PubMed ID: 19028691
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Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
Hawn TR, Scholes D, Li SS, Wang H, Yang Y, Roberts PL, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM
PLoS One. 2009
PubMed ID: 19543401
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TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Pananá E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y
PLoS One. 2009
PubMed ID: 19270748
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TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens.
Cervantes-Barragán L, Gil-Cruz C, Pastelin-Palacios R, Lang KS, Isibasi A, Ludewig B, López-Macías C
Eur J Immunol. 2009
PubMed ID: 19130558
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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis.
Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M
Nature. 2009
PubMed ID: 19122641
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A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.
Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19074283
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Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses.
Leibundgut-Landmann S, Osorio F, Brown GD, Reis e Sousa C
Blood. 2008
PubMed ID: 18818389
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FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.
Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A
J Biol Chem. 2008
PubMed ID: 18849341
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A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Chessler AD, Ferreira LR, Chang TH, Fitzgerald KA, Burleigh BA
J Immunol. 2008
PubMed ID: 19017982
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Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/beta.
Ngoi SM, Tovey MG, Vella AT
J Immunol. 2008
PubMed ID: 19017955
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Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
Eur J Immunol. 2008
PubMed ID: 19009526
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Natural selection in the TLR-related genes in the course of primate evolution.
Nakajima T, Ohtani H, Satta Y, Uno Y, Akari H, Ishida T, Kimura A
Immunogenetics. 2008
PubMed ID: 18810425
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TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis.
Ashtekar AR, Zhang P, Katz J, Deivanayagam CC, Rallabhandi P, Vogel SN, Michalek SM
J Leukoc Biol. 2008
PubMed ID: 18708593
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MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.
Shi CS, Kehrl JH
J Biol Chem. 2008
PubMed ID: 18772134
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Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis.
Bouskra D, Brézillon C, Bérard M, Werts C, Varona R, Boneca IG, Eberl G
Nature. 2008
PubMed ID: 18987631
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Chlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and -independent signaling and is reciprocally modulated by liver X receptor activation.
Chen S, Sorrentino R, Shimada K, Bulut Y, Doherty TM, Crother TR, Arditi M
J Immunol. 2008
PubMed ID: 18981140
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Toll-like receptor 4 restricts retinal progenitor cell proliferation.
Shechter R, Ronen A, Rolls A, London A, Bakalash S, Young MJ, Schwartz M
J Cell Biol. 2008
PubMed ID: 18981228
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Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes.
Haase H, Ober-Blöbaum JL, Engelhardt G, Hebel S, Heit A, Heine H, Rink L
J Immunol. 2008
PubMed ID: 18941240
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Shiga toxin-mediated disease in MyD88-deficient mice infected with Escherichia coli O157:H7.
Calderon Toledo C, Rogers TJ, Svensson M, Tati R, Fischer H, Svanborg C, Karpman D
Am J Pathol. 2008
PubMed ID: 18832584
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The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Rebsamen M, Meylan E, Curran J, Tschopp J
Cell Death Differ. 2008
PubMed ID: 18756281
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The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement.
Caminschi I, Proietto AI, Ahmet F, Kitsoulis S, Shin Teh J, Lo JC, Rizzitelli A, Wu L, Vremec D, van Dommelen SL, Campbell IK, Maraskovsky E, Braley H, Davey GM, Mottram P, van de Velde N, Jensen K, Lew AM, Wright MD, Heath WR, Shortman K, Lahoud MH
Blood. 2008
PubMed ID: 18669894
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ATP drives lamina propria T(H)17 cell differentiation.
Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K
Nature. 2008
PubMed ID: 18716618
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
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Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, Beutler BA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18806225
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TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol.
Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, Reiser J, Kolls JK
J Immunol. 2008
PubMed ID: 18713975
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TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice.
Spiller S, Elson G, Ferstl R, Dreher S, Mueller T, Freudenberg M, Daubeuf B, Wagner H, Kirschning CJ
J Exp Med. 2008
PubMed ID: 18644971
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Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation.
Shen H, Tesar BM, Walker WE, Goldstein DR
J Immunol. 2008
PubMed ID: 18641322
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Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
Xu H, An H, Hou J, Han C, Wang P, Yu Y, Cao X
Mol Immunol. 2008
PubMed ID: 18571728
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Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA.
Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M
Nature. 2008
PubMed ID: 18548002
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Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/lpr mice.
Kobayashi T, Takahashi K, Nagai Y, Shibata T, Otani M, Izui S, Akira S, Gotoh Y, Kiyono H, Miyake K
Int Immunol. 2008
PubMed ID: 18492657
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Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.
Funami K, Sasai M, Oshiumi H, Seya T, Matsumoto M
J Biol Chem. 2008
PubMed ID: 18450748
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Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1.
Upton JW, Kaiser WJ, Mocarski ES
J Biol Chem. 2008
PubMed ID: 18442983
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Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system.
Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, Hayashi N, Hoshino T, Fujimoto J, Nakanishi K
Int Immunol. 2008
PubMed ID: 18448455
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Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta.
Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K
J Biol Chem. 2008
PubMed ID: 18319258
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Mast cell-mediated immune responses through IgE antibody and Toll-like receptor 4 by malarial peroxiredoxin.
Furuta T, Imajo-Ohmi S, Fukuda H, Kano S, Miyake K, Watanabe N
Eur J Immunol. 2008
PubMed ID: 18398934
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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
Guo B, Chang EY, Cheng G
J Clin Invest. 2008
PubMed ID: 18382764
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Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation.
Burgdorf S, Schölz C, Kautz A, Tampé R, Kurts C
Nat Immunol. 2008
PubMed ID: 18376402
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Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.
Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM
Cell. 2008
PubMed ID: 18423196
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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi JZ, Albuquerque RJ, Yamasaki S, Itaya M, Pan Y, Appukuttan B, Gibbs D, Yang Z, Karikó K, Ambati BK, Wilgus TA, DiPietro LA, Sakurai E, Zhang K, Smith JR, Taylor EW, Ambati J
Nature. 2008
PubMed ID: 18368052
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Villous B cells of the small intestine are specialized for invariant NK T cell dependence.
Velázquez P, Wei B, McPherson M, Mendoza LM, Nguyen SL, Turovskaya O, Kronenberg M, Huang TT, Schrage M, Lobato LN, Fujiwara D, Brewer S, Arditi M, Cheng G, Sartor RB, Newberry RD, Braun J
J Immunol. 2008
PubMed ID: 18354186
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TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.
Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R
Nat Immunol. 2008
PubMed ID: 18297073
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.
Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS
J Leukoc Biol. 2008
PubMed ID: 18211965
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Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling.
Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K
Biochem Biophys Res Commun. 2008
PubMed ID: 18222170
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Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways.
De Filippo K, Henderson RB, Laschinger M, Hogg N
J Immunol. 2008
PubMed ID: 18322244
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Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway.
Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, Aoyagi T, Shiratori K, Takeda K, Akira S, Saijo S, Iwakura Y, Adachi Y, Ohno N, Suzuki K, Fujita J, Kaku M, Kawakami K
J Immunol. 2008
PubMed ID: 18322216
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The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A
Immunity. 2008
PubMed ID: 18342009
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Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
J Immunol. 2008
PubMed ID: 18250459
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MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase.
Johnson AC, Li X, Pearlman E
J Biol Chem. 2008
PubMed ID: 18057004
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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S
Nature. 2008
PubMed ID: 18256672
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Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta.
Ha H, Lee JH, Kim HN, Kwak HB, Kim HM, Lee SE, Rhee JH, Kim HH, Lee ZH
J Immunol. 2008
PubMed ID: 18209032
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Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
Kumar H, Koyama S, Ishii KJ, Kawai T, Akira S
J Immunol. 2008
PubMed ID: 18178804
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Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.
Kimman TG, Banus S, Reijmerink N, Reimerink J, Stelma FF, Koppelman GH, Thijs C, Postma DS, Kerkhof M
PLoS ONE. 2008
PubMed ID: 18987746
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Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury.
Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC
PLoS ONE. 2008
PubMed ID: 18974879
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MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei.
Wiersinga WJ, Wieland CW, Roelofs JJ, van der Poll T
PLoS ONE. 2008
PubMed ID: 18946505
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Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection.
Hutchens MA, Luker KE, Sonstein J, Núñez G, Curtis JL, Luker GD
PLoS Pathog. 2008
PubMed ID: 18802464
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Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.
Jung A, Kato H, Kumagai Y, Kumar H, Kawai T, Takeuchi O, Akira S
J Virol. 2008
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ATP-sensitive potassium channels mediate survival during infection in mammals and insects.
Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, Eleftherianos I, Imler JL, Beutler B
Nat Genet. 2007
PubMed ID: 18026101
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IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I
J Clin Invest. 2007
PubMed ID: 17992263
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IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals.
Ho LH, Ohno T, Oboki K, Kajiwara N, Suto H, Iikura M, Okayama Y, Akira S, Saito H, Galli SJ, Nakae S
J Leukoc Biol. 2007
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Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.
Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M
J Immunol. 2007
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Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc.
De Luca A, Montagnoli C, Zelante T, Bonifazi P, Bozza S, Moretti S, D'Angelo C, Vacca C, Boon L, Bistoni F, Puccetti P, Fallarino F, Romani L
J Immunol. 2007
PubMed ID: 17947673
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Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S
J Immunol. 2007
PubMed ID: 17878370
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Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2.
Ferwerda G, Kullberg BJ, de Jong DJ, Girardin SE, Langenberg DM, van Crevel R, Ottenhoff TH, Van der Meer JW, Netea MG
J Leukoc Biol. 2007
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Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
Cook P, Tötemeyer S, Stevenson C, Fitzgerald KA, Yamamoto M, Akira S, Maskell DJ, Bryant CE
Immunology. 2007
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Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance.
Biswas SK, Bist P, Dhillon MK, Kajiji T, Del Fresno C, Yamamoto M, Lopez-Collazo E, Akira S, Tergaonkar V
J Immunol. 2007
PubMed ID: 17785847
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Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway.
Werts C, le Bourhis L, Liu J, Magalhaes JG, Carneiro LA, Fritz JH, Stockinger S, Balloy V, Chignard M, Decker T, Philpott DJ, Ma X, Girardin SE
Eur J Immunol. 2007
PubMed ID: 17705131
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Polyinosinic acid is a ligand for toll-like receptor 3.
Marshall-Clarke S, Downes JE, Haga IR, Bowie AG, Borrow P, Pennock JL, Grencis RK, Rothwell P
J Biol Chem. 2007
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Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors.
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FEBS Lett. 2007
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IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3.
Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, Willems F, Goldman M, Goriely S
J Immunol. 2007
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TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help.
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Blood. 2007
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MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.
Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL
J Exp Med. 2007
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Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
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Virology. 2007
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Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production.
Chang EY, Guo B, Doyle SE, Cheng G
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Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.
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Nat Immunol. 2007
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Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17.
LeibundGut-Landmann S, Gross O, Robinson MJ, Osorio F, Slack EC, Tsoni SV, Schweighoffer E, Tybulewicz V, Brown GD, Ruland J, Reis e Sousa C
Nat Immunol. 2007
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TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways.
Shigeoka AA, Holscher TD, King AJ, Hall FW, Kiosses WB, Tobias PS, Mackman N, McKay DB
J Immunol. 2007
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Type I interferon signaling is required for activation of the inflammasome during Francisella infection.
Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM
J Exp Med. 2007
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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
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Nat Rev Immunol. 2007
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Murine cerebral malaria development is independent of toll-like receptor signaling.
Togbe D, Schofield L, Grau GE, Schnyder B, Boissay V, Charron S, Rose S, Beutler B, Quesniaux VF, Ryffel B
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MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection.
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J Immunol. 2007
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Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
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Immunity. 2007
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Innate immune response to adenoviral vectors is mediated by both Toll-like receptor-dependent and -independent pathways.
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J Virol. 2007
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MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.
Alugupalli KR, Akira S, Lien E, Leong JM
J Immunol. 2007
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A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice.
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J Immunol. 2007
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Cell-associated double-stranded RNA enhances antitumor activity through the production of type I IFN.
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A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria.
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Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
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