CSK

Summary Top Help

Gene Description:

c-src tyrosine kinase

Synonyms:

Csk, AW212630, CSK

Orthologs:

Human CSK (protein-coding), Mouse Csk (protein-coding), Rat Csk (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr15:75074398..75095539 (21.14 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:57474453..57501438 (26.98 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:61381336..61386013 (4.68 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CSK:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CSK:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 4

Reactome: 11

NCI-Nature Pathway Interaction Database: 6

Gene Ontology: 24

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 281

SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T
Mol Cell Biol. 2011
PubMed ID: 21930792
25-Methoxyhispidol A, a novel triterpenoid of Poncirus trifoliata, inhibits cell growth via the modulation of EGFR/c-Src signaling pathway in MDA-MB-231 human breast cancer cells.
Chung HJ, Park EJ, Pyee Y, Hua Xu G, Lee SH, Kim YS, Lee SK
Food Chem Toxicol. 2011
PubMed ID: 21782877
Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src.
Place AT, Chen Z, Bakhshi FR, Liu G, O'Bryan JP, Minshall RD
Mol Pharmacol. 2011
PubMed ID: 21778303
PTPIP51 is phosphorylated by Lyn and c-Src kinases lacking dephosphorylation by PTP1B in acute myeloid leukemia.
Brobeil A, Bobrich M, Graf M, Kruchten A, Blau W, Rummel M, Oeschger S, Steger K, Wimmer M
Leuk Res. 2011
PubMed ID: 21513978
Evidence that the kinase-truncated c-Src regulates NF-κB signaling by targeting NEMO.
Dai S, Abu-Amer W, Karuppaiah K, Abu-Amer Y
J Cell Biochem. 2011
PubMed ID: 21538482
Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.
Ia KK, Jeschke GR, Deng Y, Kamaruddin MA, Williamson NA, Scanlon DB, Culvenor JG, Hossain MI, Purcell AW, Liu S, Zhu HJ, Catimel B, Turk BE, Cheng HC
Biochemistry. 2011
PubMed ID: 21699177
Oncogenic Ras/Src cooperativity in pancreatic neoplasia.
Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA
Oncogene. 2011
PubMed ID: 21242978
Albumin-induced epithelial-mesenchymal transition and ER stress are regulated through a common ROS-c-Src kinase-mTOR pathway: effect of imatinib mesylate.
Lee JY, Chang JW, Yang WS, Kim SB, Park SK, Park JS, Lee SK
Am J Physiol Renal Physiol. 2011
PubMed ID: 21367918
Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation.
Mizrachy-Schwartz S, Cohen N, Klein S, Kravchenko-Balasha N, Levitzki A
J Biol Chem. 2011
PubMed ID: 21245141
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE
PLoS Genet. 2011
PubMed ID: 21490707
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates SRC kinase activity in brain maturation.
Lindquist S, Karitkina D, Langnaese K, Posevitz-Fejfar A, Schraven B, Xavier R, Seed B, Lindquist JA
PLoS One. 2011
PubMed ID: 21915273
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
The transmembrane adaptor Cbp/PAG1 controls the malignant potential of human non-small cell lung cancers that have c-src upregulation.
Kanou T, Oneyama C, Kawahara K, Okimura A, Ohta M, Ikeda N, Shintani Y, Okumura M, Okada M
Mol Cancer Res. 2011
PubMed ID: 21156787
RhoH modulates pre-TCR and TCR signalling by regulating LCK.
Wang H, Zeng X, Fan Z, Lim B
Cell Signal. 2011
PubMed ID: 20851766
Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.
Ho JE, Levy D, Rose L, Johnson AD, Ridker PM, Chasman DI
J Hypertens. 2010
PubMed ID: 21045733
Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.
Niu W, Zhang Y, Ji K, Gu M, Gao P, Zhu D
Clin Chim Acta. 2010
PubMed ID: 20542020
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
Role of the Yes and Csk tyrosine kinases in the development of a pathological state in the human retina.
Baranova L, Emelyanova V, Volotovski I
Mol Biol Rep. 2010
PubMed ID: 19757166
Hydrophobic interaction between the SH2 domain and the kinase domain is required for the activation of Csk.
Mikkola ET, Gahmberg CG
J Mol Biol. 2010
PubMed ID: 20434462
Blood pressure and hypertension are associated with 7 loci in the Japanese population.
Takeuchi F, Isono M, Katsuya T, Yamamoto K, Yokota M, Sugiyama T, Nabika T, Fujioka A, Ohnaka K, Asano H, Yamori Y, Yamaguchi S, Kobayashi S, Takayanagi R, Ogihara T, Kato N
Circulation. 2010
PubMed ID: 20479155
Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.
Hong KW, Jin HS, Lim JE, Kim S, Go MJ, Oh B
J Hum Genet. 2010
PubMed ID: 20414254
Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts.
Matsubara T, Ikeda F, Hata K, Nakanishi M, Okada M, Yasuda H, Nishimura R, Yoneda T
J Bone Miner Res. 2010
PubMed ID: 19874196
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A
Immunity. 2010
PubMed ID: 20346773
Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization.
Sirvent A, Bénistant C, Pannequin J, Veracini L, Simon V, Bourgaux JF, Hollande F, Cruzalegui F, Roche S
Oncogene. 2010
PubMed ID: 20010872
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion.
Rahman MA, Senga T, Ito S, Hyodo T, Hasegawa H, Hamaguchi M
J Biol Chem. 2010
PubMed ID: 19948721
Myoglobin induces vascular cell adhesion molecule-1 expression through c-Src kinase-activator protein-1/nuclear factor-kappaB pathways.
Kim SH, Chang JW, Kim SB, Park SK, Park JS, Lee SK
Nephron Exp Nephrol. 2010
PubMed ID: 19887846
The prognostic role of phospho-Src family kinase analysis in tongue cancer.
Ben-Izhak O, Cohen-Kaplan V, Nagler RM
J Cancer Res Clin Oncol. 2010
PubMed ID: 19565264
Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain.
Oneyama C, Iino T, Saito K, Suzuki K, Ogawa A, Okada M
Mol Cell Biol. 2009
PubMed ID: 19822664
Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling.
Amanchy R, Zhong J, Hong R, Kim JH, Gucek M, Cole RN, Molina H, Pandey A
Mol Oncol. 2009
PubMed ID: 19632164
Genetic variations in ATP2B1, CSK, ARSG and CSMD1 loci are related to blood pressure and/or hypertension in two Korean cohorts.
Hong KW, Go MJ, Jin HS, Lim JE, Lee JY, Han BG, Hwang SY, Lee SH, Park HK, Cho YS, Oh B
J Hum Hypertens. 2009
PubMed ID: 19960030
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.
Enomoto M, Hayakawa S, Itsukushima S, Ren DY, Matsuo M, Tamada K, Oneyama C, Okada M, Takumi T, Nishita M, Minami Y
Oncogene. 2009
PubMed ID: 19561643
A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias.
Kreil S, Hochhaus A, Cross NC, Chase A
Leuk Res. 2009
PubMed ID: 19464057
Structural characterization of the natively unfolded N-terminal domain of human c-Src kinase: insights into the role of phosphorylation of the unique domain.
Pérez Y, Gairí M, Pons M, Bernadó P
J Mol Biol. 2009
PubMed ID: 19520085
The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons.
D'Arco M, Giniatullin R, Leone V, Carloni P, Birsa N, Nair A, Nistri A, Fabbretti E
J Biol Chem. 2009
PubMed ID: 19509283
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling.
Johnsen IB, Nguyen TT, Bergstroem B, Fitzgerald KA, Anthonsen MW
J Biol Chem. 2009
PubMed ID: 19419966
Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells.
Pan S, World CJ, Kovacs CJ, Berk BC
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19359662
Gene and microRNA expression in p53-deficient day 8.5 mouse embryos.
Hosako H, Martin GS, Barrier M, Chen YA, Ivanov IV, Mirkes PE
Birth Defects Res A Clin Mol Teratol. 2009
PubMed ID: 19229884
Genome-wide association study identifies eight loci associated with blood pressure.
Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Jarvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB
Nat Genet. 2009
PubMed ID: 19430483
Genome-wide association study of blood pressure and hypertension.
Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM
Nat Genet. 2009
PubMed ID: 19430479
Insulin promotes the association of heat shock protein 90 with the inositol 1,4,5-trisphosphate receptor to dampen its Ca2+ release activity.
Nguyen N, Francoeur N, Chartrand V, Klarskov K, Guillemette G, Boulay G
Endocrinology. 2009
PubMed ID: 19147678
SRC family kinases are required for limb trajectory selection by spinal motor axons.
Kao TJ, Palmesino E, Kania A
J Neurosci. 2009
PubMed ID: 19403835
[Lipid rafts controls the oncogenic potential of c-Src]
Oneyama C, Okada M
Tanpakushitsu Kakusan Koso. 2009
PubMed ID: 19288857
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell. 2009
PubMed ID: 19167335
The tyrosine kinase Csk dimerizes through Its SH3 domain.
Levinson NM, Visperas PR, Kuriyan J
PLoS One. 2009
PubMed ID: 19888460
Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells.
Meyn MA, Smithgall TE
Sci Signal. 2009
PubMed ID: 19825829
Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization.
Vacaresse N, Møller B, Danielsen EM, Okada M, Sap J
J Biol Chem. 2008
PubMed ID: 18948260
Alveolar macrophages from septic mice promote polymorphonuclear leukocyte transendothelial migration via an endothelial cell Src kinase/NADPH oxidase pathway.
Wang Z, Rui T, Yang M, Valiyeva F, Kvietys PR
J Immunol. 2008
PubMed ID: 19050294
Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer.
Campbell EJ, McDuff E, Tatarov O, Tovey S, Brunton V, Cooke TG, Edwards J
Br J Cancer. 2008
PubMed ID: 19018258
[Cloning and analysis of coding cDNA sequence of human lymphocyte Csk tyrosine kinase under normal conditions and in choroidal melanoma]
Baranova LA, Emel'ianova VP, Zhornik EV, Minov AM, Naumenko LV, Volotovskiĭ ID
Izv Akad Nauk Ser Biol. 2008
PubMed ID: 19198071
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Potential molecular mechanism for c-Src kinase-mediated regulation of intestinal cell migration.
Mathew S, George SP, Wang Y, Siddiqui MR, Srinivasan K, Tan L, Khurana S
J Biol Chem. 2008
PubMed ID: 18482983
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.
Veracini L, Simon V, Richard V, Schraven B, Horejsi V, Roche S, Benistant C
J Cell Biol. 2008
PubMed ID: 18695048
Structural basis for the recognition of c-Src by its inactivator Csk.
Levinson NM, Seeliger MA, Cole PA, Kuriyan J
Cell. 2008
PubMed ID: 18614016
Control of excitatory synaptic transmission by C-terminal Src kinase.
Xu J, Weerapura M, Ali MK, Jackson MF, Li H, Lei G, Xue S, Kwan CL, Manolson MF, Yang K, Macdonald JF, Yu XM
J Biol Chem. 2008
PubMed ID: 18445593
Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase.
Epple H, Cremasco V, Zhang K, Mao D, Longmore GD, Faccio R
Mol Cell Biol. 2008
PubMed ID: 18378693
The lipid raft-anchored adaptor protein Cbp controls the oncogenic potential of c-Src.
Oneyama C, Hikita T, Enya K, Dobenecker MW, Saito K, Nada S, Tarakhovsky A, Okada M
Mol Cell. 2008
PubMed ID: 18498747
Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.
Bennett HL, Brummer T, Jeanes A, Yap AS, Daly RJ
Oncogene. 2008
PubMed ID: 17998934
Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase.
Liang F, Luo Y, Dong Y, Walls CD, Liang J, Jiang HY, Sanford JR, Wek RC, Zhang ZY
J Biol Chem. 2008
PubMed ID: 18268019
Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S
J Biol Chem. 2008
PubMed ID: 18258597
Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility.
Takatsuka A, Yagi R, Koike M, Oneyama C, Nada S, Schmedt C, Uchiyama Y, Okada M
Dev Biol. 2008
PubMed ID: 18262517
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
Cortesio CL, Chan KT, Perrin BJ, Burton NO, Zhang S, Zhang ZY, Huttenlocher A
J Cell Biol. 2008
PubMed ID: 18332219
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.
Saito K, Enya K, Oneyama C, Hikita T, Okada M
Biochem Biophys Res Commun. 2008
PubMed ID: 18086565
Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.
Supekova L, Supek F, Lee J, Chen S, Gray N, Pezacki JP, Schlapbach A, Schultz PG
J Biol Chem. 2008
PubMed ID: 17951261
Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.
Zambuzzi WF, Granjeiro JM, Parikh K, Yuvaraj S, Peppelenbosch MP, Ferreira CV
Cell Physiol Biochem. 2008
PubMed ID: 19088431
Functional dissection of transformation by c-Src and v-Src.
Oneyama C, Hikita T, Nada S, Okada M
Genes Cells. 2008
PubMed ID: 18173743
c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site.
Baumgartner M, Radziwill G, Lorger M, Weiss A, Moelling K
Mol Cell Biol. 2008
PubMed ID: 18039857
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts.
Destaing O, Sanjay A, Itzstein C, Horne WC, Toomre D, De Camilli P, Baron R
Mol Biol Cell. 2008
PubMed ID: 17978100
c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.
Weiss A, Baumgartner M, Radziwill G, Dennler J, Moelling K
FEBS Lett. 2007
PubMed ID: 17936276
Differential mitotic activation of endogenous c-Src, c-Yes, and Lyn in HeLa cells.
Kuga T, Nakayama Y, Hoshino M, Higashiyama Y, Obata Y, Matsuda D, Kasahara K, Fukumoto Y, Yamaguchi N
Arch Biochem Biophys. 2007
PubMed ID: 17692281
Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk.
Honda K, Sakaguchi T, Sakai K, Schmedt C, Ramirez A, Jorcano JL, Tarakhovsky A, Kamisoyama H, Sakai T
Carcinogenesis. 2007
PubMed ID: 17494055
Subdomain switching reveals regions that harbor substrate specificity and regulatory properties of protein tyrosine kinases.
Wang YH, Huang K, Lin X, Sun G
Biochemistry. 2007
PubMed ID: 17691821
Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation.
Lim MJ, Seo YH, Choi KJ, Cho CH, Kim BS, Kim YH, Lee J, Lee H, Jung CY, Ha J, Kang I, Kim SS
Arch Biochem Biophys. 2007
PubMed ID: 17612500
Endothelin-1, but not Ang II, activates MAP kinases through c-Src independent Ras-Raf dependent pathways in vascular smooth muscle cells.
Yogi A, Callera GE, Montezano AC, Aranha AB, Tostes RC, Schiffrin EL, Touyz RM
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17569879
[Obtaining a full-length encoding cDNA of Csk family tyrosine kinase from human lymphocytes]
Emel'ianova VP, Baranova LA, Zhornik EV, Naumenko LV, Birich TA, Volotovskiĭ ID
Mol Biol (Mosk). 2007
PubMed ID: 17936985
A transmembrane osteoclastic protein-tyrosine phosphatase regulates osteoclast activity in part by promoting osteoclast survival through c-Src-dependent activation of NFkappaB and JNK2.
Amoui M, Sheng MH, Chen ST, Baylink DJ, Lau KH
Arch Biochem Biophys. 2007
PubMed ID: 17400176
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.
Di Stefano P, Damiano L, Cabodi S, Aramu S, Tordella L, Praduroux A, Piva R, Cavallo F, Forni G, Silengo L, Tarone G, Turco E, Defilippi P
EMBO J. 2007
PubMed ID: 17525734
Regulation of c-Src by binding to the PDZ domain of AF-6.
Radziwill G, Weiss A, Heinrich J, Baumgartner M, Boisguerin P, Owada K, Moelling K
EMBO J. 2007
PubMed ID: 17491594
Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.
Sahu SN, Nunez S, Bai G, Gupta A
Am J Physiol Cell Physiol. 2007
PubMed ID: 17329398
CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation.
Dey N, De PK, Wang M, Zhang H, Dobrota EA, Robertson KA, Durden DL
Mol Cell Biol. 2007
PubMed ID: 17325034
Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity.
Liu J, Shimosawa T, Matsui H, Meng F, Supowit SC, DiPette DJ, Ando K, Fujita T
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17071733
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
C-terminal Src kinase controls development and maintenance of mouse squamous epithelia.
Yagi R, Waguri S, Sumikawa Y, Nada S, Oneyama C, Itami S, Schmedt C, Uchiyama Y, Okada M
EMBO J. 2007
PubMed ID: 17304209
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
A novel disulfide bond in the SH2 Domain of the C-terminal Src kinase controls catalytic activity.
Mills JE, Whitford PC, Shaffer J, Onuchic JN, Adams JA, Jennings PA
J Mol Biol. 2007
PubMed ID: 17137590
c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells.
Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17012367
Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells.
Park S, Dong B, Matsumura F
Biochemistry. 2007
PubMed ID: 17223712
Germline gain-of-function mutations in SOS1 cause Noonan syndrome.
Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS
Nat Genet. 2007
PubMed ID: 17143285
SRC tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase Csk.
Lieser SA, Shaffer J, Adams JA
J Biol Chem. 2006
PubMed ID: 17018524
Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation.
Romaker D, Schregel V, Maurer K, Auerochs S, Marzi A, Sticht H, Marschall M
J Med Chem. 2006
PubMed ID: 17125257
Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity.
Wilson GR, Cramer A, Welman A, Knox F, Swindell R, Kawakatsu H, Clarke RB, Dive C, Bundred NJ
Br J Cancer. 2006
PubMed ID: 17060931
Regulation of c-Src activity by the expression of wild-type v-Src and its kinase-dead double Y416F-K295N mutant.
Vojtechová M, Senigl F, Sloncová E, Tuhácková Z
Arch Biochem Biophys. 2006
PubMed ID: 17056000
Increases in c-Src expression level and activity do not promote the growth of human colorectal carcinoma cells in vitro and in vivo.
Welman A, Cawthorne C, Ponce-Perez L, Barraclough J, Danson S, Murray S, Cummings J, Allen TD, Dive C
Neoplasia. 2006
PubMed ID: 17132222
A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.
McDaniel AH, Li X, Tordoff MG, Bachmanov AA, Reed DR
Mamm Genome. 2006
PubMed ID: 17103052
Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.
Ingley E, Schneider JR, Payne CJ, McCarthy DJ, Harder KW, Hibbs ML, Klinken SP
J Biol Chem. 2006
PubMed ID: 16920712
EG-1 interacts with c-Src and activates its signaling pathway.
Lu M, Zhang L, Sartippour MR, Norris AJ, Brooks MN
Int J Oncol. 2006
PubMed ID: 16964398
Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation.
Jiang LQ, Feng X, Zhou W, Knyazev PG, Ullrich A, Chen Z
Oncogene. 2006
PubMed ID: 16636672
Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src.
Longworth MS, Laimins LA
Oncogene. 2006
PubMed ID: 16532030
Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
Johnsen IB, Nguyen TT, Ringdal M, Tryggestad AM, Bakke O, Lien E, Espevik T, Anthonsen MW
EMBO J. 2006
PubMed ID: 16858407
COOH-terminal Src kinase-mediated c-Jun phosphorylation promotes c-Jun degradation and inhibits cell transformation.
Zhu F, Choi BY, Ma WY, Zhao Z, Zhang Y, Cho YY, Choi HS, Imamoto A, Bode AM, Dong Z
Cancer Res. 2006
PubMed ID: 16740711
Role of tyrosine kinase Csk in G protein-coupled receptor- and receptor tyrosine kinase-induced fibroblast cell migration.
McGarrigle D, Shan D, Yang S, Huang XY
J Biol Chem. 2006
PubMed ID: 16501257
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Analysis of the DNA sequence and duplication history of human chromosome 15.
Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16572171
Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, C-terminal Src kinase (Csk).
Lee S, Ayrapetov MK, Kemble DJ, Parang K, Sun G
J Biol Chem. 2006
PubMed ID: 16439366
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling.
Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK
EMBO J. 2006
PubMed ID: 16511561
Csk mediates G-protein-coupled lysophosphatidic acid receptor-induced inhibition of membrane-bound guanylyl cyclase activity.
Madhusoodanan KS, Guo D, McGarrigle DK, Maack T, Huang XY
Biochemistry. 2006
PubMed ID: 16519534
Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells.
Galliher AJ, Schiemann WP
Breast Cancer Res. 2006
PubMed ID: 16859511
Leukocyte-associated Ig-like receptor-1 has SH2 domain-containing phosphatase-independent function and recruits C-terminal Src kinase.
Verbrugge A, Rijkers ES, de Ruiter T, Meyaard L
Eur J Immunol. 2006
PubMed ID: 16380958
New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors.
Barlaam B, Fennell M, Germain H, Green T, Hennequin L, Morgentin R, Olivier A, Plé P, Vautier M, Costello G
Bioorg Med Chem Lett. 2005
PubMed ID: 16203139
Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.
Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, Lottspeich F, Hrabé de Angelis M, Beckers J
Gene Expr Patterns. 2005
PubMed ID: 15979417
Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts.
Shah K, Vincent F
Mol Biol Cell. 2005
PubMed ID: 16135530
Cbp deficiency alters Csk localization in lipid rafts but does not affect T-cell development.
Xu S, Huo J, Tan JE, Lam KP
Mol Cell Biol. 2005
PubMed ID: 16166631
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.
Chong YP, Mulhern TD, Cheng HC
Growth Factors. 2005
PubMed ID: 16243715
Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation.
Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods VL, Jennings PA
J Mol Biol. 2005
PubMed ID: 16002086
Integrins and Src: dynamic duo of adhesion signaling.
Shattil SJ
Trends Cell Biol. 2005
PubMed ID: 16005629
Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation.
Ayrapetov MK, Nam NH, Ye G, Kumar A, Parang K, Sun G
J Biol Chem. 2005
PubMed ID: 15890649
Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation.
Kunte DP, Wali RK, Koetsier JL, Hart J, Kostjukova MN, Kilimnik AY, Pyatkin IG, Strelnikova SR, Roy HK
FEBS Lett. 2005
PubMed ID: 15961079
CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity.
Dey N, Howell BW, De PK, Durden DL
Exp Cell Res. 2005
PubMed ID: 15890337
Association of Csk to VE-cadherin and inhibition of cell proliferation.
Baumeister U, Funke R, Ebnet K, Vorschmitt H, Koch S, Vestweber D
EMBO J. 2005
PubMed ID: 15861137
Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages.
Aki D, Mashima R, Saeki K, Minoda Y, Yamauchi M, Yoshimura A
Genes Cells. 2005
PubMed ID: 15773898
Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition.
Lieser SA, Shindler C, Aubol BE, Lee S, Sun G, Adams JA
J Biol Chem. 2005
PubMed ID: 15623523
Removal of C-terminal SRC kinase from the immune synapse by a new binding protein.
Rahmouni S, Vang T, Alonso A, Williams S, van Stipdonk M, Soncini C, Moutschen M, Schoenberger SP, Mustelin T
Mol Cell Biol. 2005
PubMed ID: 15743820
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.
Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P
J Biol Chem. 2005
PubMed ID: 15574420
Functional role of c-Src in IL-1-induced NF-kappa B activation: c-Src is a component of the IKK complex.
Funakoshi-Tago M, Tago K, Andoh K, Sonoda Y, Tominaga S, Kasahara T
J Biochem. 2005
PubMed ID: 15749833
Protein kinases and adherens junction dynamics in the seminiferous epithelium of the rat testis.
Lee NP, Cheng CY
J Cell Physiol. 2005
PubMed ID: 15389520
Phosphotyrosine interactome of the ErbB-receptor kinase family.
Schulze WX, Deng L, Mann M
Mol Syst Biol. 2005
PubMed ID: 16729043
Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin.
Melendez J, Turner C, Avraham H, Steinberg SF, Schaefer E, Sussman MA
J Biol Chem. 2004
PubMed ID: 15322113
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Recruitment of C-terminal Src kinase by the leukocyte inhibitory receptor CD85j.
Sayós J, Martínez-Barriocanal A, Kitzig F, Bellón T, López-Botet M
Biochem Biophys Res Commun. 2004
PubMed ID: 15474475
Integrins direct Src family kinases to regulate distinct phases of oligodendrocyte development.
Colognato H, Ramachandrappa S, Olsen IM, ffrench-Constant C
J Cell Biol. 2004
PubMed ID: 15504915
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Identification of tyrosine kinases expressed in the male mouse gubernaculum during development.
Verma-Kurvari S, Parada LF
Dev Dyn. 2004
PubMed ID: 15254900
The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.
Rafalska I, Zhang Z, Benderska N, Wolff H, Hartmann AM, Brack-Werner R, Stamm S
Hum Mol Genet. 2004
PubMed ID: 15175272
Expression of p50 C-terminal Src kinase (Csk) in mouse testis.
Gye MC, Choi JK, Ahn HS, Kim YS
Arch Androl. 2004
PubMed ID: 15277007
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src.
Davidson L, Pawson AJ, López de Maturana R, Freestone SH, Barran P, Millar RP, Maudsley S
J Biol Chem. 2004
PubMed ID: 14707140
Interaction of bcl-2 with Paxillin through its BH4 domain is important during ureteric bud branching.
Sorenson CM
J Biol Chem. 2004
PubMed ID: 14699151
Oxidative stress activates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and paxillin.
Cao H, Sanguinetti AR, Mastick CC
Exp Cell Res. 2004
PubMed ID: 14980511
Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3.
Robson JD, Davidson D, Veillette A
Mol Cell Biol. 2004
PubMed ID: 14993273
Dual roles of the C-terminal Src kinase (Csk) during developmental vascularization.
Duan LJ, Imamoto A, Fong GH
Blood. 2004
PubMed ID: 14576066
Mechanism of Csk-mediated down-regulation of Src family tyrosine kinases in epidermal growth factor signaling.
Matsuoka H, Nada S, Okada M
J Biol Chem. 2004
PubMed ID: 14613929
Quantitative trait Loci specifying the response of body temperature to dietary restriction.
Rikke BA, Yerg JE, Battaglia ME, Nagy TR, Allison DB, Johnson TE
J Gerontol A Biol Sci Med Sci. 2004
PubMed ID: 14999024
C-terminal SRC kinase controls acute inflammation and granulocyte adhesion.
Thomas RM, Schmedt C, Novelli M, Choi BK, Skok J, Tarakhovsky A, Roes J
Immunity. 2004
PubMed ID: 14975240
Disruption of Ca2+-dependent cell-matrix adhesion enhances c-Src kinase activity, but causes dissociation of the c-Src/FAK complex and dephosphorylation of tyrosine-577 of FAK in carcinoma cells.
Lin EH, Hui AY, Meens JA, Tremblay EA, Schaefer E, Elliott BE
Exp Cell Res. 2004
PubMed ID: 14729052
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Phospholipase C-independent activation of glycogen synthase kinase-3beta and C-terminal Src kinase by Galphaq.
Fan G, Ballou LM, Lin RZ
J Biol Chem. 2003
PubMed ID: 14561750
The role of c-Src in platelet-derived growth factor alpha receptor internalization.
Avrov K, Kazlauskas A
Exp Cell Res. 2003
PubMed ID: 14644164
Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase.
Lee S, Lin X, Nam NH, Parang K, Sun G
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14657361
LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsí V
J Exp Med. 2003
PubMed ID: 14610046
Functions of the activation loop in Csk protein-tyrosine kinase.
Lin X, Lee S, Sun G
J Biol Chem. 2003
PubMed ID: 12686554
Corneal IL-8 expression following adenovirus infection is mediated by c-Src activation in human corneal fibroblasts.
Natarajan K, Rajala MS, Chodosh J
J Immunol. 2003
PubMed ID: 12794155
Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK.
Mikkola ET, Bergman M
FEBS Lett. 2003
PubMed ID: 12782282
Concentration of rafts in platelet filopodia correlates with recruitment of c-Src and CD63 to these domains.
Heijnen HF, Van Lier M, Waaijenborg S, Ohno-Iwashita Y, Waheed AA, Inomata M, Gorter G, Möbius W, Akkerman JW, Slot JW
J Thromb Haemost. 2003
PubMed ID: 12871315
C-terminal Src kinase (CSK) modulates insulin-like growth factor-I signaling through Src in 3T3-L1 differentiation.
Sekimoto H, Boney CM
Endocrinology. 2003
PubMed ID: 12746317
Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling.
Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K
J Biol Chem. 2003
PubMed ID: 12665526
Src-mediated RGS16 tyrosine phosphorylation promotes RGS16 stability.
Derrien A, Zheng B, Osterhout JL, Ma YC, Milligan G, Farquhar MG, Druey KM
J Biol Chem. 2003
PubMed ID: 12588871
Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression.
Huang WC, Chen JJ, Inoue H, Chen CC
J Immunol. 2003
PubMed ID: 12707358
Transmodulation between phospholipase D and c-Src enhances cell proliferation.
Ahn BH, Kim SY, Kim EH, Choi KS, Kwon TK, Lee YH, Chang JS, Kim MS, Jo YH, Min DS
Mol Cell Biol. 2003
PubMed ID: 12697812
Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt.
Gu J, Nada S, Okada M, Sekiguchi K
Biochem Biophys Res Commun. 2003
PubMed ID: 12670507
Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer.
Basuroy S, Sheth P, Kuppuswamy D, Balasubramanian S, Ray RM, Rao RK
J Biol Chem. 2003
PubMed ID: 12547828
Positive and negative regulation of T-cell activation through kinases and phosphatases.
Mustelin T, Taskén K
Biochem J. 2003
PubMed ID: 12485116
c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression.
Huang WC, Chen JJ, Chen CC
J Biol Chem. 2003
PubMed ID: 12645577
Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptor.
Davidson D, Bakinowski M, Thomas ML, Horejsi V, Veillette A
Mol Cell Biol. 2003
PubMed ID: 12612075
Characterization of a novel negative regulator (DOC-2/DAB2) of c-Src in normal prostatic epithelium and cancer.
Zhou J, Scholes J, Hsieh JT
J Biol Chem. 2003
PubMed ID: 12473651
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells.
Yamamoto Y, Maruyama T, Sakai N, Sakurai R, Shimizu A, Hamatani T, Masuda H, Uchida H, Sabe H, Yoshimura Y
Mol Hum Reprod. 2002
PubMed ID: 12468645
Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells.
Jones RJ, Avizienyte E, Wyke AW, Owens DW, Brunton VG, Frame MC
Br J Cancer. 2002
PubMed ID: 12402152
RACK1: a novel substrate for the Src protein-tyrosine kinase.
Chang BY, Harte RA, Cartwright CA
Oncogene. 2002
PubMed ID: 12400005
High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system.
Mandine E, Jean-Baptiste V, Vayssière B, Gofflo D, Bénard D, Sarubbi E, Deprez P, Baron R, Superti-Furga G, Lesuisse D
Biochem Biophys Res Commun. 2002
PubMed ID: 12387813
Cutting edge: Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells.
Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, Minaki Y, Kato A, Tani-Ichi S, Hamaoka T, Kosugi A
J Immunol. 2002
PubMed ID: 12218089
Mutation of csk, encoding the C-terminal Src kinase, reduces Pseudomonas aeruginosa internalization by mammalian cells and enhances bacterial cytotoxicity.
Evans DJ, Kuo TC, Kwong M, Van R, Fleiszig SM
Microb Pathog. 2002
PubMed ID: 12220990
Adaptor protein Shc is an isoform-specific direct activator of the tyrosine kinase c-Src.
Sato K, Nagao T, Kakumoto M, Kimoto M, Otsuki T, Iwasaki T, Tokmakov AA, Owada K, Fukami Y
J Biol Chem. 2002
PubMed ID: 12048194
c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs.
Ostareck-Lederer A, Ostareck DH, Cans C, Neubauer G, Bomsztyk K, Superti-Furga G, Hentze MW
Mol Cell Biol. 2002
PubMed ID: 12052863
Csk, a critical link of g protein signals to actin cytoskeletal reorganization.
Lowry WE, Huang J, Ma YC, Ali S, Wang D, Williams DM, Okada M, Cole PA, Huang XY
Dev Cell. 2002
PubMed ID: 12062086
ERK8, a new member of the mitogen-activated protein kinase family.
Abe MK, Saelzler MP, Espinosa R, Kahle KT, Hershenson MB, Le Beau MM, Rosner MR
J Biol Chem. 2002
PubMed ID: 11875070
Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis.
González-Guerrico AM, Cafferata EG, Radrizzani M, Marcucci F, Gruenert D, Pivetta OH, Favaloro RR, Laguens R, Perrone SV, Gallo GC, Santa-Coloma TA
J Biol Chem. 2002
PubMed ID: 11872746
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo.
Lerner EC, Smithgall TE
Nat Struct Biol. 2002
PubMed ID: 11976726
Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain.
Nicolas G, Fournier CM, Galand C, Malbert-Colas L, Bournier O, Kroviarski Y, Bourgeois M, Camonis JH, Dhermy D, Grandchamp B, Lecomte MC
Mol Cell Biol. 2002
PubMed ID: 11971983
Structure of the carboxyl-terminal Src kinase, Csk.
Ogawa A, Takayama Y, Sakai H, Chong KT, Takeuchi S, Nakagawa A, Nada S, Okada M, Tsukihara T
J Biol Chem. 2002
PubMed ID: 11884384
Regulation of an ERG K+ current by Src tyrosine kinase.
Cayabyab FS, Schlichter LC
J Biol Chem. 2002
PubMed ID: 11834728
Effects of src-deficiency on the expression of in vivo toxicity of TCDD in a strain of c-src knockout mice procured through six generations of backcrossings to C57BL/6 mice.
Dunlap DY, Ikeda I, Nagashima H, Vogel CF, Matsumura F
Toxicology. 2002
PubMed ID: 11882352
A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase.
Cao H, Courchesne WE, Mastick CC
J Biol Chem. 2002
PubMed ID: 11805080
RGS16 function is regulated by epidermal growth factor receptor-mediated tyrosine phosphorylation.
Derrien A, Druey KM
J Biol Chem. 2001
PubMed ID: 11602604
Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.
Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP
Biochemistry. 2001
PubMed ID: 11724572
Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis.
Shekhtman A, Ghose R, Wang D, Cole PA, Cowburn D
J Mol Biol. 2001
PubMed ID: 11724538
Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin.
Schaller MD, Schaefer EM
Biochem J. 2001
PubMed ID: 11695992
A novel, specific interaction involving the Csk SH3 domain and its natural ligand.
Ghose R, Shekhtman A, Goger MJ, Ji H, Cowburn D
Nat Struct Biol. 2001
PubMed ID: 11685249
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).
Pfrepper KI, Marie-Cardine A, Simeoni L, Kuramitsu Y, Leo A, Spicka J, Hilgert I, Scherer J, Schraven B
Eur J Immunol. 2001
PubMed ID: 11433379
c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization.
Fan G, Shumay E, Malbon CC, Wang H
J Biol Chem. 2001
PubMed ID: 11278940
Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).
Schmedt C, Tarakhovsky A
J Exp Med. 2001
PubMed ID: 11283154
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.
Bourguignon LY, Zhu H, Shao L, Chen YW
J Biol Chem. 2001
PubMed ID: 11084024
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.
Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K
J Exp Med. 2001
PubMed ID: 11181701
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
A major determinant quantitative-trait locus responsible for atopic dermatitis-like skin lesions in NC/Nga mice is located on Chromosome 9.
Kohara Y, Tanabe K, Matsuoka K, Kanda N, Matsuda H, Karasuyama H, Yonekawa H
Immunogenetics. 2001
PubMed ID: 11261926
SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF.
Wang B, Lemay S, Tsai S, Veillette A
Mol Cell Biol. 2001
PubMed ID: 11158295
c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes.
Toyofuku T, Akamatsu Y, Zhang H, Kuzuya T, Tada M, Hori M
J Biol Chem. 2001
PubMed ID: 11035005
Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility.
Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E, Levy J, Gailit J, Bowtell D, Horne WC, Baron R
J Cell Biol. 2001
PubMed ID: 11149930
The protein tyrosine kinase family of the human genome.
Robinson DR, Wu YM, Lin SF
Oncogene. 2000
PubMed ID: 11114734
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Transmembrane phosphoprotein Cbp positively regulates the activity of the carboxyl-terminal Src kinase, Csk.
Takeuchi S, Takayama Y, Ogawa A, Tamura K, Okada M
J Biol Chem. 2000
PubMed ID: 10918051
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.
Ishino M, Aoto H, Sasaski H, Suzuki R, Sasaki T
FEBS Lett. 2000
PubMed ID: 10838081
A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.
Akhmedov NB, Piriev NI, Chang B, Rapoport AL, Hawes NL, Nishina PM, Nusinowitz S, Heckenlively JR, Roderick TH, Kozak CA, Danciger M, Davisson MT, Farber DB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10805811
Functional modification of a murine macrophage cell line, J744A.1, transfected with rat csk genes.
Dondog EA
Hokkaido Igaku Zasshi. 2000
PubMed ID: 10884975
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B
J Exp Med. 2000
PubMed ID: 10790433
Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases.
Kawabuchi M, Satomi Y, Takao T, Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M
Nature. 2000
PubMed ID: 10801129
beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis.
Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ
J Biol Chem. 2000
PubMed ID: 10753943
Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells.
Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK
Exp Cell Res. 2000
PubMed ID: 10739664
Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling.
Lemay S, Davidson D, Latour S, Veillette A
Mol Cell Biol. 2000
PubMed ID: 10733577
Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts.
Takayanagi H, Juji T, Miyazaki T, Iizuka H, Takahashi T, Isshiki M, Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, Nakamura K, Tanaka S
J Clin Invest. 1999
PubMed ID: 10411542
Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity.
Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, Akira S
Oncogene. 1999
PubMed ID: 10376525
Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner.
Farooq A, Plotnikova O, Zeng L, Zhou MM
J Biol Chem. 1999
PubMed ID: 10037694
C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor.
Arbet-Engels C, Tartare-Deckert S, Eckhart W
J Biol Chem. 1999
PubMed ID: 10026153
Reduced C-terminal Src kinase (Csk) activities in hepatocellular carcinoma.
Masaki T, Okada M, Tokuda M, Shiratori Y, Hatase O, Shirai M, Nishioka M, Omata M
Hepatology. 1999
PubMed ID: 9918913
Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.
Thomas SM, Hagel M, Turner CE
J Cell Sci. 1999
PubMed ID: 9858471
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Identification of Tyr438 as the major in vitro c-Src phosphorylation site in human gelsolin: a mass spectrometric approach.
De Corte V, Demol H, Goethals M, Van Damme J, Gettemans J, Vandekerckhove J
Protein Sci. 1999
PubMed ID: 10210201
Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation.
Sun G, Sharma AK, Budde RJ
Oncogene. 1998
PubMed ID: 9794236
Csk controls antigen receptor-mediated development and selection of T-lineage cells.
Schmedt C, Saijo K, Niidome T, Kühn R, Aizawa S, Tarakhovsky A
Nature. 1998
PubMed ID: 9732874
Mouse nicotinamide N-methyltransferase gene: molecular cloning, structural characterization, and chromosomal localization.
Yan L, Otterness DM, Kozak CA, Weinshilboum RM
DNA Cell Biol. 1998
PubMed ID: 9726248
Human immunodeficiency virus tat modulates the Flk-1/KDR receptor, mitogen-activated protein kinases, and components of focal adhesion in Kaposi's sarcoma cells.
Ganju RK, Munshi N, Nair BC, Liu ZY, Gill P, Groopman JE
J Virol. 1998
PubMed ID: 9621077
Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases.
Cao MY, Huber M, Beauchemin N, Famiglietti J, Albelda SM, Veillette A
J Biol Chem. 1998
PubMed ID: 9624175
Sequence requirements for association of protein-tyrosine phosphatase PEP with the Src homology 3 domain of inhibitory tyrosine protein kinase p50(csk).
Gregorieff A, Cloutier JF, Veillette A
J Biol Chem. 1998
PubMed ID: 9582365
Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth.
Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng HB, Rauvala H
J Biol Chem. 1998
PubMed ID: 9553134
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling.
Honda Z, Suzuki T, Hirose N, Aihara M, Shimizu T, Nada S, Okada M, Ra C, Morita Y, Ito K
J Biol Chem. 1997
PubMed ID: 9325302
Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.
Sun G, Budde RJ
Arch Biochem Biophys. 1997
PubMed ID: 9281320
Differential effects of B cell receptor and B cell receptor-FcgammaRIIB1 engagement on docking of Csk to GTPase-activating protein (GAP)-associated p62.
Vuica M, Desiderio S, Schneck JP
J Exp Med. 1997
PubMed ID: 9221755
Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn.
Ruzzene M, Songyang Z, Marin O, Donella-Deana A, Brunati AM, Guerra B, Agostinis P, Cantley LC, Pinna LA
Eur J Biochem. 1997
PubMed ID: 9208935
Role of Csk in neural differentiation of the embryonic carcinoma cell line P19.
Takayama Y, Nada S, Nagai K, Okada M
FEBS Lett. 1997
PubMed ID: 9109376
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.
Joukov V, Vihinen M, Vainikka S, Sowadski JM, Alitalo K, Bergman M
Biochem J. 1997
PubMed ID: 9148770
The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ
J Clin Invest. 1997
PubMed ID: 9062339
CSK associates with the TCR zeta and epsilon chains via its SH2 domain; a mechanism for turning off TCR signaling.
Catipović B
Lijec Vjesn. 1996
PubMed ID: 9172452
Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.
Cloutier JF, Veillette A
EMBO J. 1996
PubMed ID: 8890164
Mapping of unconventional myosins in mouse and human.
Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA
Genomics. 1996
PubMed ID: 8884266
Impaired development of CD4+ CD8+ thymoyctes by csk-'knock-in' into fyn locus.
Kanazawa S, Ilic D, Hashiyama M, Okada M, Noumura T, Aizawa S, Suda T
Oncogene. 1996
PubMed ID: 8700547
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Pecker I, Avraham KB, Gilbert DJ, Savitsky K, Rotman G, Harnik R, Fukao T, Schröck E, Hirotsune S, Tagle DA, Collins FS, Wynshaw-Boris A, Ried T, Copeland NG, Jenkins NA, Shiloh Y, Ziv Y
Genomics. 1996
PubMed ID: 8661102
Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.
Law DA, Nannizzi-Alaimo L, Phillips DR
J Biol Chem. 1996
PubMed ID: 8631894
A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474
A comparative study of the phosphotyrosyl phosphatase specificity of protein phosphatase type 2A and phosphotyrosyl phosphatase type 1B using phosphopeptides and the phosphoproteins p50/HS1, c-Fgr and Lyn.
Agostinis P, Donella-Deana A, Van Hoof C, Cesaro L, Brunati AM, Ruzzene M, Merlevede W, Pinna LA, Goris J
Eur J Biochem. 1996
PubMed ID: 8612628
The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src.
Neet K, Hunter T
Mol Cell Biol. 1995
PubMed ID: 7544435
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton.
Thomas SM, Soriano P, Imamoto A
Nature. 1995
PubMed ID: 7617039
Presence of alternative 5' untranslated sequences and identification of cells expressing ctk transcripts in the brain and testis.
Kaneko Y, Nonoguchi K, Fukuyama H, Takano S, Higashitsuji H, Nishiyama H, Takenawa J, Nakayama H, Fujita J
Oncogene. 1995
PubMed ID: 7898936
Control of lymphopoiesis by p50csk, a regulatory protein tyrosine kinase.
Gross JA, Appleby MW, Chien S, Nada S, Bartelmez SH, Okada M, Aizawa S, Perlmutter RM
J Exp Med. 1995
PubMed ID: 7836905
Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading.
Bergman M, Joukov V, Virtanen I, Alitalo K
Mol Cell Biol. 1995
PubMed ID: 7529872
Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene.
Chow LM, Davidson D, Fournel M, Gosselin P, Lemieux S, Lyu MS, Kozak CA, Matis LA, Veillette A
Oncogene. 1994
PubMed ID: 7970703
Identification of major tyrosine-phosphorylated proteins in Csk-deficient cells.
Nada S, Okada M, Aizawa S, Nakagawa H
Oncogene. 1994
PubMed ID: 7526315
Regulation of Src family kinases in the developing rat brain: correlation with their regulator kinase, Csk.
Inomata M, Takayama Y, Kiyama H, Nada S, Okada M, Nakagawa H
J Biochem. 1994
PubMed ID: 7529760
Regulation of c-Fgr protein kinase by c-Src kinase (CSK) and by polycationic effectors.
Ruzzene M, James P, Brunati AM, Donella-Deana A, Pinna LA
J Biol Chem. 1994
PubMed ID: 7515063
Ntk: a Csk-related protein-tyrosine kinase expressed in brain and T lymphocytes.
Chow LM, Jarvis C, Hu Q, Nye SH, Gervais FG, Veillette A, Matis LA
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8197166
Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.
Sabe H, Hata A, Okada M, Nakagawa H, Hanafusa H
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7513429
Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.
Klages S, Adam D, Class K, Fargnoli J, Bolen JB, Penhallow RC
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7511815
The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop.
Borchert TV, Mathieu M, Zeelen JP, Courtneidge SA, Wierenga RK
FEBS Lett. 1994
PubMed ID: 7511113
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
Non-receptor tyrosine kinases in mammalian neurogenesis.
Aizawa S, Yagi T, Furuta Y, Ikawa Y, Nada S, Nakagawa H, Okada M
Princess Takamatsu Symp. 1994
PubMed ID: 8983085
Functional and physical interaction of protein-tyrosine kinases Fyn and Csk in the T-cell signaling system.
Takeuchi M, Kuramochi S, Fusaki N, Nada S, Kawamura-Tsuzuku J, Matsuda S, Semba K, Toyoshima K, Okada M, Yamamoto T
J Biol Chem. 1993
PubMed ID: 8262983
Constitutive activation of Src family kinases in mouse embryos that lack Csk.
Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S
Cell. 1993
PubMed ID: 8513497
Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.
Imamoto A, Soriano P
Cell. 1993
PubMed ID: 7685657
Characterization of the human CSK locus.
Bräuninger A, Karn T, Strebhardt K, Rübsamen-Waigmann H
Oncogene. 1993
PubMed ID: 7683131
Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).
Bougeret C, Rothhut B, Jullien P, Fischer S, Benarous R
Oncogene. 1993
PubMed ID: 7683130
Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.
MacAuley A, Okada M, Nada S, Nakagawa H, Cooper JA
Oncogene. 1993
PubMed ID: 7678701
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
Gilardi-Hebenstreit P, Nieto MA, Frain M, Mattéi MG, Chestier A, Wilkinson DG, Charnay P
Oncogene. 1992
PubMed ID: 1281307
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
Bergman M, Mustelin T, Oetken C, Partanen J, Flint NA, Amrein KE, Autero M, Burn P, Alitalo K
EMBO J. 1992
PubMed ID: 1639064
Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases.
Bräuninger A, Holtrich U, Strebhardt K, Rübsamen-Waigmann H
Gene. 1992
PubMed ID: 1371489
The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25.
Armstrong E, Cannizzaro L, Bergman M, Huebner K, Alitalo K
Cytogenet Cell Genet. 1992
PubMed ID: 1377109
CSK: a protein-tyrosine kinase involved in regulation of src family kinases.
Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H
J Biol Chem. 1991
PubMed ID: 1722201
Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.
Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1720539
cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).
Partanen J, Armstrong E, Bergman M, Mäkelä TP, Hirvonen H, Huebner K, Alitalo K
Oncogene. 1991
PubMed ID: 1945408
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src.
Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H
Nature. 1991
PubMed ID: 1709258
Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen.
Cheng SH, Espino PC, Marshall J, Harvey R, Merrill J, Smith AE
J Virol. 1991
PubMed ID: 1985196

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1445	12988	315707
EnsEMBL Gene(s)	ENSG00000103653	ENSMUSG00000032312	ENSRNOG00000019374
Unigene	Hs.77793	Mm.21974	Rn.2759
Homologene	CSK	Csk	Csk
OMIM	124095	N/A	N/A
GeneCards	CSK	N/A	N/A
Beta Cell Genomics	DT.101983024 DT.445561	DT.101400123 DT.493960	N/A
Reactome	P41240	N/A	N/A
Plasma Peptide Atlas	ENSP00000220003	N/A	N/A
WikiGenes	1445	12988	315707

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CSK	CDH5	HPRD	empirical	15861137
CSK	G3BP1	HPRD, MINT	empirical	15743820
CSK	CREBBP	HPRD, BioGRID	empirical	10801129
CSK	CSK	HPRD, IntAct, BioGRID	empirical	9148770 20360068
CSK	ADRB2	HPRD	empirical	11278940
CSK	SGK223	IntAct	empirical	20697350
CSK	DAB2	HPRD, BioGRID	empirical	12473651
CSK	DAG1	BioGRID	empirical	11724572
CSK	DOK1	HPRD, IntAct	empirical	9221755 20697350
CSK	EGFR	MINT, BioGRID	empirical	16729043
CSK	ERBB3	MINT, BioGRID	empirical	16729043
CSK	MAPK15	HPRD	empirical	11875070
CSK	FGR	HPRD	empirical	7515063 8612628
CSK	FHL2	IntAct	empirical	18255255
CSK	FYN	HPRD	empirical	8262983 1985196
CSK	PTPN22	HPRD, MINT	empirical	9582365
CSK	PTPN18	HPRD, MINT	empirical	11158295
CSK	GJA1	HPRD	empirical	11035005
CSK	SIT1	HPRD	empirical	11433379
CSK	GRB2	IntAct	empirical	21706016
CSK	CD274	Reactome	predicted	12947224 18173375 18759926
CSK	GSN	HPRD	empirical	10210201
CSK	HCK	HPRD	empirical	11976726
CSK	HNRNPK	HPRD, BioGRID	empirical	12052863
CSK	ID3	IntAct	empirical	18255255
CSK	IGF1R	HPRD, BioGRID	empirical	10026153
CSK	INSR	HPRD, BioGRID	empirical	10026153
CSK	JUN	BioGRID	empirical	16740711
CSK	LAIR1	HPRD	empirical	16380958
CSK	LCK	HPRD	empirical	12485116 15144186
CSK	LYN	HPRD	empirical	8612628
CSK	ARRB1	HPRD, BioGRID	empirical	10753943
CSK	PDCD1	Reactome	predicted	12947224 18173375 18759926
CSK	PECAM1	HPRD, BioGRID	empirical	9624175
CSK	PLD2	HPRD	empirical	12697812
CSK	PRKACA	HPRD	empirical	11181701
CSK	AXL	MIPS	empirical	9178760
CSK	PAG1	HPRD, BioGRID, Reactome	empirical	10790433 16920712 12938237
CSK	PARD3	MINT	empirical	17053785
CSK	PTK2	HPRD, BioGRID	empirical	7529872
CSK	PTPN12	HPRD	empirical	11158295
CSK	PTPRB	IntAct	empirical	19167335
CSK	PTPRC	IntAct	empirical	19167335
CSK	PTPRG	IntAct	empirical	19167335
CSK	PTPRJ	IntAct	empirical	19167335
CSK	PTPRK	IntAct	empirical	19167335
CSK	PTPRO	IntAct	empirical	19167335
CSK	PTPRZ1	IntAct	empirical	19167335
CSK	PXN	HPRD, MINT, BioGRID, Reactome	empirical	7529872 11695992 14665621
CSK	RASA1	HPRD, BioGRID	empirical	7544435
CSK	RGS16	HPRD	empirical	12588871 11602604
CSK	SHC1	HPRD, IntAct, BioGRID	empirical	12048194 10037694 19380743
CSK	SRC	HPRD, IntAct, BioGRID, Reactome	empirical	12387813 7678701 9208935 17525734 7513429
CSK	TGFB1I1	BioGRID	empirical	9858471
CSK	TLR3	HPRD	empirical	16858407
CSK	UBC	BioGRID	empirical	21139048 21890473
CSK	ZNF212	IntAct	empirical	18255255
CSK	DOK3	HPRD	empirical	10733577 14993273
CSK	PDCD1LG2	Reactome	predicted	12947224 18173375 18759926
CSK	SRCIN1	MINT, IntAct	empirical	17525734
CSK	UBASH3B	IntAct	empirical	19380743
CSK	CAV1	HPRD, BioGRID	empirical	11805080
CSK	CBL	IntAct, BioGRID	empirical	19380743 11149930
CSK	DOK2	MINT	empirical	15831486
CSK	YTHDC1	BioGRID	empirical	15175272
CSK	CD247	HPRD	empirical	9172452
CSK	CD44	HPRD	empirical	11084024
CSK	SDC3	HPRD, BioGRID	empirical	9553134