MAPK14

Summary Top Help

Gene Description:

mitogen-activated protein kinase 14; mitogen activated protein kinase 14

Synonyms:

CRK1, MAPK14, p38, PRKM15, CSBP, Csbp2, p38alpha, PRKM14, Exip, p38-alpha, Prkm14, RK, SAPK2A, CSBP1, Crk1, Sapk2A, Prkm15, Hog, p38MAPK, CSPB1, p38Hog, p38ALPHA, p38a, Mxi2, Mapk14, Csbp1, EXIP, CSBP2

Orthologs:

Human MAPK14 (protein-coding), Mouse Mapk14 (protein-coding), Rat Mapk14 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd16	Mouse	chr17:26318983..29405394	3.09	75	3 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr6:35995454..36079013 (83.56 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:28828287..28885350 (576 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:6939249..7000378 (61.13 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for MAPK14:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for MAPK14:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 21

Biocarta: 26

Reactome: 23

NCI-Nature Pathway Interaction Database: 32

Gene Ontology: 50

MAPK cascade	GO:0000165
Nucleotide binding	GO:0000166
Activation of MAPK activity	GO:0000187
Toll-like receptor signaling pathway	GO:0002224
MyD88-dependent toll-like receptor signaling pathway	GO:0002755
MyD88-independent toll-like receptor signaling pathway	GO:0002756
Protein serine/threonine kinase activity	GO:0004674
MAP kinase activity	GO:0004707
MAP kinase kinase activity	GO:0004708
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Cytoplasm	GO:0005737
Cytosol	GO:0005829
Apoptotic process	GO:0006915
Cellular component movement	GO:0006928
Chemotaxis	GO:0006935
Response to stress	GO:0006950
Signal transduction	GO:0007165
Cell surface receptor signaling pathway	GO:0007166
Intracellular protein kinase cascade	GO:0007243
Ras protein signal transduction	GO:0007265
Blood coagulation	GO:0007596
Toll signaling pathway	GO:0008063
Gene expression	GO:0010467
RNA metabolic process	GO:0016070
MRNA metabolic process	GO:0016071
Peptidyl-serine phosphorylation	GO:0018105
Platelet activation	GO:0030168
Osteoclast differentiation	GO:0030316
Toll-like receptor 1 signaling pathway	GO:0034130
Toll-like receptor 2 signaling pathway	GO:0034134
Toll-like receptor 3 signaling pathway	GO:0034138
Toll-like receptor 4 signaling pathway	GO:0034142
TRIF-dependent toll-like receptor signaling pathway	GO:0035666
Muscle cell differentiation	GO:0042692
Signal transduction in response to DNA damage	GO:0042770
Innate immune response	GO:0045087
Vascular endothelial growth factor receptor signaling pathway	GO:0048010
Nerve growth factor receptor signaling pathway	GO:0048011
Regulation of sequence-specific DNA binding transcription factor activity	GO:0051090
Positive regulation of muscle cell differentiation	GO:0051149
Stress-activated MAPK cascade	GO:0051403
NFAT2 protein binding	GO:0051527
3'-UTR-mediated mRNA stabilization	GO:0070935
Cellular response to growth factor stimulus	GO:0071363
Cellular response to ionizing radiation	GO:0071479
Stress-induced premature senescence	GO:0090400
Positive regulation of reactive oxygen species metabolic process	GO:2000379

Publications from PubMed Top Help

Type 1 Diabetes Publications: 17

NADPH oxidase 2-derived reactive oxygen species mediate FFAs-induced dysfunction and apoptosis of β-cells via JNK, p38 MAPK and p53 pathways.
Yuan H, Zhang X, Huang X, Lu Y, Tang W, Man Y, Wang S, Xi J, Li J
PLoS One. 2010
PubMed ID: 21209957
Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice.
Cui G, Qin X, Zhang Y, Gong Z, Ge B, Zang YQ
J Biol Chem. 2009
PubMed ID: 19661066
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of Apoptosis Signal regulating Kinase 1 constitutes a core component of the {beta}-cell pro-survival effects of glucose-dependent insulinotropic polypeptide.
Widenmaier SB, Ao Z, Kim SJ, Warnock G, McIntosh CH
J Biol Chem. 2009
PubMed ID: 19748889
p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age.
Wong ES, Le Guezennec X, Demidov ON, Marshall NT, Wang ST, Krishnamurthy J, Sharpless NE, Dunn NR, Bulavin DV
Dev Cell. 2009
PubMed ID: 19619499
p38 MAPK is a major regulator of MafA protein stability under oxidative stress.
Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A
Mol Endocrinol. 2009
PubMed ID: 19407223
Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases.
Hou N, Torii S, Saito N, Hosaka M, Takeuchi T
Endocrinology. 2008
PubMed ID: 18187551
Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells.
Makeeva N, Roomans GM, Myers JW, Welsh N
Endocrinology. 2008
PubMed ID: 17932218
Phosphorylation events implicating p38 and PI3K mediate tungstate-effects in MIN6 beta cells.
Piquer S, Barceló-Batllori S, Julià M, Marzo N, Nadal B, Guinovart JJ, Gomis R
Biochem Biophys Res Commun. 2007
PubMed ID: 17490618
Cytokine-induced osteoprotegerin expression protects pancreatic beta cells through p38 mitogen-activated protein kinase signalling against cell death.
Schrader J, Rennekamp W, Niebergall U, Schoppet M, Jahr H, Brendel MD, Hörsch D, Hofbauer LC
Diabetologia. 2007
PubMed ID: 17443309
Renal p38 MAP kinase activity in experimental diabetes.
Komers R, Lindsley JN, Oyama TT, Cohen DM, Anderson S
Lab Invest. 2007
PubMed ID: 17401436
Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells.
Makeeva N, Roomans GM, Welsh N
Int J Biol Sci. 2007
PubMed ID: 17205106
Activation of activating transcription factor 2 by p38 MAP kinase during apoptosis induced by human amylin in cultured pancreatic beta-cells.
Zhang S, Liu H, Liu J, Tse CA, Dragunow M, Cooper GJ
FEBS J. 2006
PubMed ID: 16869889
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG, Xiong Y, Daniel KW, Floering L, Collins S
J Biol Chem. 2005
PubMed ID: 16272151
Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.
Deruytter N, Boulard O, Garchon HJ
Diabetes. 2004
PubMed ID: 15561967
Abnormal p38 mitogen-activated protein kinase signalling in human and experimental diabetic nephropathy.
Adhikary L, Chow F, Nikolic-Paterson DJ, Stambe C, Dowling J, Atkins RC, Tesch GH
Diabetologia. 2004
PubMed ID: 15232685
Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis.
Saldeen J, Lee JC, Welsh N
Biochem Pharmacol. 2001
PubMed ID: 11377386
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ
Oncogene. 2000
PubMed ID: 10980603

Publications: 1710

Osteopontin stimulates autophagy via integrin/CD44 and p38 MAPK signaling pathways in vascular smooth muscle cells.
Zheng YH, Tian C, Meng Y, Qin YW, Du YH, Du J, Li HH
J Cell Physiol. 2012
PubMed ID: 21374592
Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation.
Lee BJ, Kim YJ, Cho DH, Sohn NW, Kang H
Immunopharmacol Immunotoxicol. 2011
PubMed ID: 22053946
Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway.
Tsai CW, Lin CY, Wang YJ
J Nutr. 2011
PubMed ID: 22031657
Porphyromonas gingivalis induces RANKL in bone marrow stromal cells: involvement of the p38 MAPK.
Reddi D, Brown SJ, Belibasakis GN
Microb Pathog. 2011
PubMed ID: 21939752
Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells.
Nakamura S, Takemura T, Tan L, Nagata Y, Yokota D, Hirano I, Shigeno K, Shibata K, Fujie M, Fujisawa S, Ohnishi K
Carcinogenesis. 2011
PubMed ID: 21890458
Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy.
Li D, Liu Y, Maruyama M, Zhu W, Chen H, Zhang W, Reuter S, Lin SF, Haneline LS, Field LJ, Chen PS, Shou W
Hum Mol Genet. 2011
PubMed ID: 21880664
Gas1 cooperates with Cdo and promotes myogenic differentiation via activation of p38MAPK.
Leem YE, Han JW, Lee HJ, Ha HL, Kwon YL, Ho SM, Kim BG, Tran P, Bae GU, Kang JS
Cell Signal. 2011
PubMed ID: 21820049
Fungal allergen β-glucans trigger p38 mitogen-activated protein kinase-mediated IL-6 translation in lung epithelial cells.
Neveu WA, Bernardo E, Allard JL, Nagaleekar V, Wargo MJ, Davis RJ, Iwakura Y, Whittaker LA, Rincon M
Am J Respir Cell Mol Biol. 2011
PubMed ID: 21642586
Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus.
Liao Y, Wang X, Huang M, Tam JP, Liu DX
Virology. 2011
PubMed ID: 21959016
Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways.
Dickinson RJ, Delavaine L, Cejudo-Marín R, Stewart G, Staples CJ, Didmon MP, Trinidad AG, Alonso A, Pulido R, Keyse SM
J Biol Chem. 2011
PubMed ID: 21908610
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of SMADS and TAK1 in early mouse embryo.
Miura S, Mishina Y
Dev Dyn. 2011
PubMed ID: 21953618
Epidermal growth factor-induced matrix metalloproteinase-1 expression is negatively regulated by p38 MAPK in human skin fibroblasts.
Park CH, Chung JH
J Dermatol Sci. 2011
PubMed ID: 21872446
Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner.
Luo Y, Zou P, Zou J, Wang J, Zhou D, Liu L
Exp Gerontol. 2011
PubMed ID: 21816217
Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in Ehrlich Lettré Ascites cells through a mechanism involving p38 mitogen-activated protein kinase.
Gorbatenko A, Wiwel M, Klingberg H, Nielsen AB, Kapus A, Pedersen SF
J Cell Physiol. 2011
PubMed ID: 21302281
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.
Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M
Immunity. 2011
PubMed ID: 22000287
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair.
Perdiguero E, Sousa-Victor P, Ruiz-Bonilla V, Jardí M, Caelles C, Serrano AL, Muñoz-Cánoves P
J Cell Biol. 2011
PubMed ID: 21987635
Iron deficiency activates pro-inflammatory signaling in macrophages and foam cells via the p38 MAPK-NF-κB pathway.
Fan Y, Wang J, Wei L, He B, Wang C, Wang B
Int J Cardiol. 2011
PubMed ID: 20674992
Alpha1-adrenoceptor signaling in the human prostate involves regulation of p38 mitogen-activated protein kinase.
Strittmatter F, Gratzke C, Walther S, Göttinger J, Beckmann C, Roosen A, Schlenker B, Reich O, Stief CG, Hennenberg M
Urology. 2011
PubMed ID: 21982020
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis.
Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U
Nat Med. 2011
PubMed ID: 21892182
p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.
Khan JA, Amazit L, Bellance C, Guiochon-Mantel A, Lombès M, Loosfelt H
Mol Endocrinol. 2011
PubMed ID: 21816898
Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel.
Chang HR, Chen PN, Yang SF, Sun YS, Wu SW, Hung TW, Lian JD, Chu SC, Hsieh YS
Mol Carcinog. 2011
PubMed ID: 21574189
Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cδ, and p38 mitogen-activated protein kinase (MAPK).
Thorp E, Vaisar T, Subramanian M, Mautner L, Blobel C, Tabas I
J Biol Chem. 2011
PubMed ID: 21828049
Detection of phosphorylated mitogen-activated protein kinase in the developing spinal cord of the mouse embryo.
Teraishi T, Miura K
Biochem Biophys Res Commun. 2011
PubMed ID: 21871441
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Methyl-1-hydroxy-2-naphthoate, a novel naphthol derivative, inhibits lipopolysaccharide-induced inflammatory response in macrophages via suppression of NF-κB, JNK and p38 MAPK pathways.
Zhang JY, Jin H, Wang GF, Yu PJ, Wu SY, Zhu ZG, Li ZH, Tian YX, Xu W, Zhang JJ, Wu SG
Inflamm Res. 2011
PubMed ID: 21667204
Activation of stress kinases in the brain of mucopolysaccharidosis IIIB mice.
Cecere F, Di Domenico C, Di Napoli D, Boscia F, Di Natale P
J Neurosci Res. 2011
PubMed ID: 21618584
Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.
Pengal R, Guess AJ, Agrawal S, Manley J, Ransom RF, Mourey RJ, Benndorf R, Smoyer WE
Am J Physiol Renal Physiol. 2011
PubMed ID: 21613416
p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.
Loy B, Apostolova G, Dorn R, McGuire VA, Arthur JS, Dechant G
J Neurosci. 2011
PubMed ID: 21865449
c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies.
Rzeczkowski K, Beuerlein K, Müller H, Dittrich-Breiholz O, Schneider H, Kettner-Buhrow D, Holtmann H, Kracht M
J Cell Biol. 2011
PubMed ID: 21859862
Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction.
Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, Lemos JC, Hagan CE, Neumaier JF, Quintana A, Palmiter RD, Chavkin C
Neuron. 2011
PubMed ID: 21835346
Crosstalk between Nodal/activin and MAPK p38 signaling is essential for anterior-posterior axis specification.
Clements M, Pernaute B, Vella F, Rodriguez TA
Curr Biol. 2011
PubMed ID: 21802298
Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development.
del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21768366
Age-induced augmentation of p38 MAPK phosphorylation in mouse lung.
Li Z, Li J, Bu X, Liu X, Tankersley CG, Wang C, Huang K
Exp Gerontol. 2011
PubMed ID: 21570457
Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm.
Di Giovanni V, Alday A, Chi L, Mishina Y, Rosenblum ND
Development. 2011
PubMed ID: 21613322
A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, Gandhi P, Munson M, Miyamoto S, Kelliher MA
Mol Cell Biol. 2011
PubMed ID: 21606198
Lupulone triggers p38 MAPK-controlled activation of p53 and of the TRAIL receptor apoptotic pathway in human colon cancer-derived metastatic cells.
Lamy V, Bousserouel S, Gossé F, Minker C, Lobstein A, Raul F
Oncol Rep. 2011
PubMed ID: 21519792
Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion.
Wang Y, Kellner J, Liu L, Zhou D
Stem Cells Dev. 2011
PubMed ID: 21198398
p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells.
Barruet E, Hadadeh O, Peiretti F, Renault VM, Hadjal Y, Bernot D, Tournaire R, Negre D, Juhan-Vague I, Alessi MC, Binétruy B
Stem Cells Dev. 2011
PubMed ID: 20954847
Synergistic activation by p38MAPK and glucocorticoid signaling mediates induction of M2-like tumor-associated macrophages expressing the novel CD20 homolog MS4A8A.
Schmieder A, Schledzewski K, Michel J, Tuckermann JP, Tome L, Sticht C, Gkaniatsou C, Nicolay JP, Demory A, Faulhaber J, Kzhyshkowska J, Géraud C, Goerdt S
Int J Cancer. 2011
PubMed ID: 20824698
Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor.
Bhattacharya S, Qian J, Tzimas C, Baker DP, Koumenis C, Diehl JA, Fuchs SY
J Biol Chem. 2011
PubMed ID: 21540188
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase.
Mannangatti P, Arapulisamy O, Shippenberg TS, Ramamoorthy S, Jayanthi LD
J Biol Chem. 2011
PubMed ID: 21498515
Switching of N-methyl-D-aspartate (NMDA) receptor-favorite intracellular signal pathways from ERK1/2 protein to p38 mitogen-activated protein kinase leads to developmental changes in NMDA neurotoxicity.
Xiao L, Hu C, Feng C, Chen Y
J Biol Chem. 2011
PubMed ID: 21474451
Transforming growth factor-β1 modulates lipopolysaccharide-induced cytokine/chemokine production and inhibits nuclear factor-κB, extracellular signal-regulated kinases and p38 activation in dendritic cells in mice.
Mou HB, Lin MF, Huang H, Cai Z
Transplant Proc. 2011
PubMed ID: 21693323
Differential roles of MAPK-Erk1/2 and MAPK-p38 in insulin or insulin-like growth factor-I (IGF-I) signaling pathways for progesterone production in human ovarian cells.
Seto-Young D, Avtanski D, Varadinova M, Park A, Suwandhi P, Leiser A, Parikh G, Poretsky L
Horm Metab Res. 2011
PubMed ID: 21448845
Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.
Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP
Mol Cell Biol. 2011
PubMed ID: 21444723
HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and involves both p38 and ERK1/2 signaling pathways.
Giltaire S, Lambert S, Poumay Y
J Cell Physiol. 2011
PubMed ID: 21413023
p38 MAP kinase plays a functional role in UVB-induced mouse skin carcinogenesis.
Dickinson SE, Olson ER, Zhang J, Cooper SJ, Melton T, Criswell PJ, Casanova A, Dong Z, Hu C, Saboda K, Jacobs ET, Alberts DS, Bowden GT
Mol Carcinog. 2011
PubMed ID: 21268131
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.
Wu W, Huang Q, He F, Xiao M, Pang S, Guo X, Brunk UT, Zhao K, Zhao M
Shock. 2011
PubMed ID: 21263381
c-Jun N-terminal kinase (JNK) and p38 play different roles in age-related Purkinje cell death in murine organotypic culture.
Repici M, Wehrlé R, Antoniou X, Borsello T, Dusart I
Cerebellum. 2011
PubMed ID: 21191679
Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
Sun Z, Zhang J, Zhang J, Chen C, Du Q, Chang L, Cao C, Zheng M, Garcia-Barrio MT, Chen YE, Xiao RP, Mao J, Zhu X
Biochem Biophys Res Commun. 2011
PubMed ID: 21549102
Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms.
Koivisto E, Kaikkonen L, Tokola H, Pikkarainen S, Aro J, Pennanen H, Karvonen T, Rysä J, Kerkelä R, Ruskoaho H
Mol Cell Endocrinol. 2011
PubMed ID: 21354263
Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.
Lilleholt LL, Johansen C, Arthur JS, Funding A, Bibby BM, Kragballe K, Iversen L
Acta Derm Venereol. 2011
PubMed ID: 21336470
Differentiation of human rhabdomyosarcoma RD cells is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways.
Rossi S, Stoppani E, Puri PL, Fanzani A
Eur J Cancer. 2011
PubMed ID: 21273059
Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells.
Kolosova I, Nethery D, Kern JA
J Cell Physiol. 2011
PubMed ID: 20945383
5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected].
Machida T, Ohta M, Onoguchi A, Iizuka K, Sakai M, Minami M, Hirafuji M
Eur J Pharmacol. 2011
PubMed ID: 21262218
Overexpression of IL-32alpha increases natural killer cell-mediated killing through up-regulation of Fas and UL16-binding protein 2 (ULBP2) expression in human chronic myeloid leukemia cells.
Cheon S, Lee JH, Park S, Bang SI, Lee WJ, Yoon DY, Yoon SS, Kim T, Min H, Cho BJ, Lee HJ, Lee KW, Jeong SH, Park H, Cho D
J Biol Chem. 2011
PubMed ID: 21321117
Translational control of NKT cell cytokine production by p38 MAPK.
Nagaleekar VK, Sabio G, Aktan I, Chant A, Howe IW, Thornton TM, Benoit PJ, Davis RJ, Rincon M, Boyson JE
J Immunol. 2011
PubMed ID: 21368234
The increased density of p38 mitogen-activated protein kinase-immunoreactive microglia in the sensorimotor cortex of aged TgCRND8 mice is associated predominantly with smaller dense-core amyloid plaques.
Chlan-Fourney J, Zhao T, Walz W, Mousseau DD
Eur J Neurosci. 2011
PubMed ID: 21323766
Role of C/EBP-β, p38 MAPK, and MKK6 in IL-1β-mediated C3 gene regulation in astrocytes.
Maranto J, Rappaport J, Datta PK
J Cell Biochem. 2011
PubMed ID: 21308746
Acacetin inhibits the invasion and migration of human non-small cell lung cancer A549 cells by suppressing the p38α MAPK signaling pathway.
Chien ST, Lin SS, Wang CK, Lee YB, Chen KS, Fong Y, Shih YW
Mol Cell Biochem. 2011
PubMed ID: 21210297
Nonfibrillar Abeta 1-42 inhibits glutamate uptake and phosphorylates p38 in human fibroblasts.
Zoia CP, Riva C, Isella V, Proserpio P, Terruzzi A, Arban S, Salerno D, Cassina V, Mantegazza F, Tremolizzo L, Ferrarese C
Alzheimer Dis Assoc Disord. 2011
PubMed ID: 20921877
Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids.
Li F, Zhang M, Hussain F, Triantaphyllopoulos K, Clark AR, Bhavsar PK, Zhou X, Chung KF
Eur Respir J. 2011
PubMed ID: 20693246
Mitogen activated protein kinase at the nuclear pore complex.
Faustino RS, Maddaford TG, Pierce GN
J Cell Mol Med. 2011
PubMed ID: 20497490
Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells.
Svensson C, Part K, Künnis-Beres K, Kaldmäe M, Fernaeus SZ, Land T
Biochem Biophys Res Commun. 2011
PubMed ID: 21338578
The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells.
Kim JH, Lee JO, Lee SK, Moon JW, You GY, Kim SJ, Park SH, Park JM, Lim SY, Suh PG, Uhm KO, Song MS, Kim HS
J Biol Chem. 2011
PubMed ID: 21193401
N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.
Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K, Okawa K, Inoue H, Kawamata J, Shimohama S, Arai T, Takahashi R, Kinoshita A
J Biol Chem. 2011
PubMed ID: 21177868
Regulation of the endothelial plasminogen activator system by fluvastatin. Role of Rho family proteins, actin polymerisation and p38 MAP kinase.
Dunoyer-Geindre S, Fish RJ, Kruithof EK
Thromb Haemost. 2011
PubMed ID: 21174002
Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathways.
Kim HA, Seo GY, Kim PH
J Leukoc Biol. 2011
PubMed ID: 21169521
Tanshinone IIA acts via p38 MAPK to induce apoptosis and the down-regulation of ERCC1 and lung-resistance protein in cisplatin-resistant ovarian cancer cells.
Jiao JW, Wen F
Oncol Rep. 2011
PubMed ID: 21165580
MAPK14 cooperates with MAPK3/1 to regulate endothelin-1-mediated prostaglandin synthase 2 induction and survival in leiomyoma but not in normal myometrial cells.
Oyeniran C, Tanfin Z
Biol Reprod. 2011
PubMed ID: 21084714
Pro-inflammatory angiogenesis is mediated by p38 MAP kinase.
Rajashekhar G, Kamocka M, Marin A, Suckow MA, Wolter WR, Badve S, Sanjeevaiah AR, Pumiglia K, Rosen E, Clauss M
J Cell Physiol. 2011
PubMed ID: 20803566
Blood-derived human osteoclast resorption activity is impaired by Hyaluronan-CD44 engagement via a p38-dependent mechanism.
Pivetta E, Scapolan M, Wassermann B, Steffan A, Colombatti A, Spessotto P
J Cell Physiol. 2011
PubMed ID: 20799279
Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase.
Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, Fan J
Am J Respir Cell Mol Biol. 2011
PubMed ID: 20418360
Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells.
Lepage C, Léger DY, Bertrand J, Martin F, Beneytout JL, Liagre B
Cancer Lett. 2011
PubMed ID: 21195543
Expression and functional validation of new p38α transcriptional targets in tumorigenesis.
Swat A, Dolado I, Igea A, Gomez-Lopez G, Pisano DG, Cuadrado A, Nebreda AR
Biochem J. 2011
PubMed ID: 21226672
Critical role of the transient activation of p38 MAPK in the etiology of skeletal muscle insulin resistance induced by low-level in vitro oxidant stress.
Diamond-Stanic MK, Marchionne EM, Teachey MK, Durazo DE, Kim JS, Henriksen EJ
Biochem Biophys Res Commun. 2011
PubMed ID: 21241662
Inhibition of p38 mitogen-activated protein kinase improves nitric oxide-mediated vasodilatation and reduces inflammation in hypercholesterolemia.
Cheriyan J, Webb AJ, Sarov-Blat L, Elkhawad M, Wallace SM, Mäki-Petäjä KM, Collier DJ, Morgan J, Fang Z, Willette RN, Lepore JJ, Cockcroft JR, Sprecher DL, Wilkinson IB
Circulation. 2011
PubMed ID: 21262998
p38 MAPK controls prothrombin expression by regulated RNA 3' end processing.
Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gröne HJ, Schirmacher P, Hentze MW, Kulozik AE
Mol Cell. 2011
PubMed ID: 21292162
Active mutants of the TCR-mediated p38α alternative activation site show changes in the phosphorylation lip and DEF site formation.
Tzarum N, Diskin R, Engelberg D, Livnah O
J Mol Biol. 2011
PubMed ID: 21146537
Heme oxygenase-1/carbon monoxide induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1.
Lin HH, Lai SC, Chau LY
J Biol Chem. 2011
PubMed ID: 21115498
The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.
Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K
J Biol Chem. 2011
PubMed ID: 21098484
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW
Oncogene. 2011
PubMed ID: 20871633
Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.
Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY
J Immunol. 2011
PubMed ID: 21187450
MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation.
Sun BK, Kim JH, Nguyen HN, Oh S, Kim SY, Choi S, Choi HJ, Lee YJ, Song JJ
Oncol Rep. 2011
PubMed ID: 21152872
Differential gene expression analysis identifies murine Cacnb3 as strongly upregulated in distinct dendritic cell populations upon stimulation.
Bros M, Dexheimer N, Ross R, Trojandt S, Höhn Y, Tampe J, Sutter A, Jährling F, Grabbe S, Reske-Kunz AB
Gene. 2011
PubMed ID: 21040760
Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells.
Lajevic MD, Suleiman S, Cohen RL, Chambers DA
Immunology. 2011
PubMed ID: 21039464
CD40 engagement on dendritic cells induces cyclooxygenase-2 and EP2 receptor via p38 and ERK MAPKs.
Harizi H, Limem I, Gualde N
Immunol Cell Biol. 2011
PubMed ID: 20697426
Effects of asialo-erythropoietin on pain-related behavior and expression of phosphorylated-p38 map kinase and tumor necrosis factor-alpha induced by application of autologous nucleus pulposus on nerve root in rat.
Sasaki N, Sekiguchi M, Kikuchi S, Konno S
Spine (Phila Pa 1976). 2011
PubMed ID: 21228694
p38 MAPK activation is downstream of the loss of intercellular adhesion in pemphigus vulgaris.
Mao X, Sano Y, Park JM, Payne AS
J Biol Chem. 2011
PubMed ID: 21078676
Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy.
Lee JY, Lee YM, Chang GC, Yu SL, Hsieh WY, Chen JJ, Chen HW, Yang PC
PLoS One. 2011
PubMed ID: 21858220
ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells.
Karmarkar SW, Bottum KM, Krager SL, Tischkau SA
PLoS One. 2011
PubMed ID: 21858143
Probiotic-derived polyphosphate enhances the epithelial barrier function and maintains intestinal homeostasis through integrin-p38 MAPK pathway.
Segawa S, Fujiya M, Konishi H, Ueno N, Kobayashi N, Shigyo T, Kohgo Y
PLoS One. 2011
PubMed ID: 21858054
Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-κB in rats with trigeminal neuropathic pain.
Lee MK, Han SR, Park MK, Kim MJ, Bae YC, Kim SK, Park JS, Ahn DK
Mol Pain. 2011
PubMed ID: 21816109
HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner.
Fu X, Lawson MA, Kelley KW, Dantzer R
J Neuroinflammation. 2011
PubMed ID: 21810259
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).
Bachstetter AD, Xing B, de Almeida L, Dimayuga ER, Watterson DM, Van Eldik LJ
J Neuroinflammation. 2011
PubMed ID: 21733175
Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development.
Vesterlund L, Töhönen V, Hovatta O, Kere J
Int J Dev Biol. 2011
PubMed ID: 21710437
Endothelial and macrophage-specific deficiency of P38α MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice.
Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M
PLoS One. 2011
PubMed ID: 21695272
p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.
Wen HC, Avivar-Valderas A, Sosa MS, Girnius N, Farias EF, Davis RJ, Aguirre-Ghiso JA
Sci Signal. 2011
PubMed ID: 21610252
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
Green JA, Dholakia S, Janczar K, Ong CW, Moores R, Fry J, Elkington PT, Roncaroli F, Friedland JS
J Neuroinflammation. 2011
PubMed ID: 21569377
Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1.
Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, Wells S, Cheeseman M, Xia Y, Ostrer H, Greenfield A
PLoS One. 2011
PubMed ID: 21559298
Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase.
Turpeinen T, Nieminen R, Taimi V, Heittola T, Sareila O, Clark AR, Moilanen E, Korhonen R
Mediators Inflamm. 2011
PubMed ID: 21547253
Loss of ATF2 function leads to cranial motoneuron degeneration during embryonic mouse development.
Ackermann J, Ashton G, Lyons S, James D, Hornung JP, Jones N, Breitwieser W
PLoS One. 2011
PubMed ID: 21533046
[Study on p38 mitogen activated protein kinase in vascular endothelial cells dysfunction in preeclampsia].
Luo X, Liu DD, Qi HB, Yao ZW
Zhonghua Fu Chan Ke Za Zhi. 2011
PubMed ID: 21429433
Kinase activity profiling of gram-negative pneumonia.
Hoogendijk AJ, Diks SH, Peppelenbosch MP, Van Der Poll T, Wieland CW
Mol Med. 2011
PubMed ID: 21424109
p38 MAPK-Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation.
Kim J, Hwangbo J, Wong PK
PLoS One. 2011
PubMed ID: 21305053
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
An H, Lu X, Liu D, Yarbrough WG
PLoS One. 2011
PubMed ID: 21283629
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response.
Kerkelä R, Ilves M, Pikkarainen S, Tokola H, Ronkainen VP, Majalahti T, Leppäluoto J, Vuolteenaho O, Ruskoaho H
Am J Physiol Regul Integr Comp Physiol. 2011
PubMed ID: 21084678
Effect of resveratrol on gliotransmitter levels and p38 activities in cultured astrocytes.
Zhou H, Chen Q, Kong DL, Guo J, Wang Q, Yu SY
Neurochem Res. 2011
PubMed ID: 20842424
Osmotic stress inhibits proteasome by p38 MAPK-dependent phosphorylation.
Lee SH, Park Y, Yoon SK, Yoon JB
J Biol Chem. 2010
PubMed ID: 21044959
p38 maintains E-cadherin expression by modulating TAK1-NF-kappa B during epithelial-to-mesenchymal transition.
Strippoli R, Benedicto I, Foronda M, Perez-Lozano ML, Sánchez-Perales S, López-Cabrera M, Del Pozo MÁ
J Cell Sci. 2010
PubMed ID: 21098640
Hydroureternephrosis due to loss of Sox9-regulated smooth muscle cell differentiation of the ureteric mesenchyme.
Airik R, Trowe MO, Foik A, Farin HF, Petry M, Schuster-Gossler K, Schweizer M, Scherer G, Kist R, Kispert A
Hum Mol Genet. 2010
PubMed ID: 20881014
Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways.
Lee GT, Kwon SJ, Lee JH, Jeon SS, Jang KT, Choi HY, Lee HM, Kim WJ, Kim SJ, Kim IY
J Biol Chem. 2010
PubMed ID: 20889504
The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution.
Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ
Structure. 2010
PubMed ID: 21134636
[Effect of cadmium chloride on the expression and phosphorylation of mitogen-activated protein kinase in normal rat kidney epithelial cells].
Xu XY, Ke YB, Ding LP, Yuan JH, Zhou L, Li XY, Liu YF
Zhonghua Yu Fang Yi Xue Za Zhi. 2010
PubMed ID: 21215118
NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway.
Wynne S, Djakiew D
Mol Cancer Res. 2010
PubMed ID: 21097678
Homocysteine enhances cell proliferation in vascular smooth muscle cells: role of p38 MAPK and p47phox.
Zou T, Yang W, Hou Z, Yang J
Acta Biochim Biophys Sin (Shanghai). 2010
PubMed ID: 21068125
UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate.
Gong X, Liu A, Ming X, Deng P, Jiang Y
FEBS Lett. 2010
PubMed ID: 21050851
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
J Clin Invest. 2010
PubMed ID: 21041952
Interaction of Snail and p38 mitogen-activated protein kinase results in shorter overall survival of ovarian cancer patients.
Hipp S, Berg D, Ergin B, Schuster T, Hapfelmeier A, Walch A, Avril S, Schmalfeldt B, Höfler H, Becker KF
Virchows Arch. 2010
PubMed ID: 20957493
Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.
Hall EH, Balsbaugh JL, Rose KL, Shabanowitz J, Hunt DF, Brautigan DL
Mol Cell Proteomics. 2010
PubMed ID: 20798394
A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice.
Ewen K, Jackson A, Wilhelm D, Koopman P
Biol Reprod. 2010
PubMed ID: 20739663
Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.
Leshem-Lev D, Hochhauser E, Chanyshev B, Isak A, Shainberg A
Mol Cell Biochem. 2010
PubMed ID: 20730620
Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes.
Schram K, De Girolamo S, Madani S, Munoz D, Thong F, Sweeney G
Cell Mol Biol Lett. 2010
PubMed ID: 20683677
Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition.
Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y
J Invest Dermatol. 2010
PubMed ID: 20631726
Antibodies protect against intracellular bacteria by Fc receptor-mediated lysosomal targeting.
Joller N, Weber SS, Müller AJ, Spörri R, Selchow P, Sander P, Hilbi H, Oxenius A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21048081
Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.
Chang Z, Zhang Q, Feng Q, Xu J, Teng T, Luan Q, Shan C, Hu Y, Hemmings BA, Gao X, Yang Z
Dev Biol. 2010
PubMed ID: 20816796
Modulation of doxorubicin-induced cardiac dysfunction in dominant-negative p38α mitogen-activated protein kinase mice.
Thandavarayan RA, Watanabe K, Sari FR, Ma M, Lakshmanan AP, Giridharan VV, Gurusamy N, Nishida H, Konishi T, Zhang S, Muslin AJ, Kodama M, Aizawa Y
Free Radic Biol Med. 2010
PubMed ID: 20705132
Synergistic activation of NF-{kappa}B by bacterial chemoattractant and TNF{alpha} is mediated by p38 MAPK-dependent RelA acetylation.
Pan WW, Li JD, Huang S, Papadimos TJ, Pan ZK, Chen LY
J Biol Chem. 2010
PubMed ID: 20729202
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1.
Méndez-Samperio P, Pérez A, Alba L
Arch Med Res. 2010
PubMed ID: 21199725
A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism.
Marchant D, Singhera GK, Utokaparch S, Hackett TL, Boyd JH, Luo Z, Si X, Dorscheid DR, McManus BM, Hegele RG
J Virol. 2010
PubMed ID: 20702616
Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
Eur J Hum Genet. 2010
PubMed ID: 20588308
Transcriptional upregulation of DDR2 by ATF4 facilitates osteoblastic differentiation through p38 MAPK-mediated Runx2 activation.
Lin KL, Chou CH, Hsieh SC, Hwa SY, Lee MT, Wang FF
J Bone Miner Res. 2010
PubMed ID: 20564243
Hyaluronan inhibits p38 mitogen-activated protein kinase via the receptors in rheumatoid arthritis chondrocytes stimulated with fibronectin fragment.
Yasuda T
Clin Rheumatol. 2010
PubMed ID: 20552237
Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling.
Chen JR, Lazarenko OP, Wu X, Kang J, Blackburn ML, Shankar K, Badger TM, Ronis MJ
J Bone Miner Res. 2010
PubMed ID: 20499363
PPARγ agonist pioglitazone inhibits microglia inflammation by blocking p38 mitogen-activated protein kinase signaling pathways.
Ji H, Wang H, Zhang F, Li X, Xiang L, Aiguo S
Inflamm Res. 2010
PubMed ID: 20495845
p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription.
Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H
Stem Cells Dev. 2010
PubMed ID: 20412016
Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism.
Hagenacker T, Hillebrand I, Büsselberg D, Schäfers M
Brain Res Bull. 2010
PubMed ID: 20655989
Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.
Mardini L, Gasiorek J, Derjuga A, Carrière L, Schranzhofer M, Paw BH, Ponka P, Blank V
Biochem J. 2010
PubMed ID: 20738258
Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.
Arana-Argáez VE, Delgado-Rizo V, Pizano-Martínez OE, Martínez-Garcia EA, Martín-Márquez BT, Muñoz-Gómez A, Petri MH, Armendáriz-Borunda J, Espinosa-Ramírez G, Zúñiga-Tamayo DA, Herrera-Esparza R, Vázquez-Del Mercado M
J Biol Chem. 2010
PubMed ID: 20729213
p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.
Menon MB, Schwermann J, Singh AK, Franz-Wachtel M, Pabst O, Seidler U, Omary MB, Kotlyarov A, Gaestel M
J Biol Chem. 2010
PubMed ID: 20724476
Novel changes in NF-{kappa}B activity during progression and regression phases of hyperplasia: role of MEK, ERK, and p38.
Chandrakesan P, Ahmed I, Anwar T, Wang Y, Sarkar S, Singh P, Peleg S, Umar S
J Biol Chem. 2010
PubMed ID: 20710027
p38α MAPK is a MTOC-associated protein regulating spindle assembly, spindle length and accurate chromosome segregation during mouse oocyte meiotic maturation.
Ou XH, Li S, Xu BZ, Wang ZB, Quan S, Li M, Zhang QH, Ouyang YC, Schatten H, Xing FQ, Sun QY
Cell Cycle. 2010
PubMed ID: 20948319
p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix.
Ortuño MJ, Ruiz-Gaspà S, Rodríguez-Carballo E, Susperregui AR, Bartrons R, Rosa JL, Ventura F
J Biol Chem. 2010
PubMed ID: 20682789
Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways.
Han DS, Huang HP, Wang TG, Hung MY, Ke JY, Chang KT, Chang HY, Ho YP, Hsieh WY, Yang WS
J Cell Biochem. 2010
PubMed ID: 20568119
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB
Mol Cell. 2010
PubMed ID: 20932473
The p38 SAPK is recruited to chromatin via its interaction with transcription factors.
Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M, Posas F
J Biol Chem. 2010
PubMed ID: 20682780
Dendritic cell differentiation blocked by primary effusion lymphoma-released factors is partially restored by inhibition of P38 MAPK.
Cirone M, Di Renzo L, Trivedi P, Lucania G, Borgia G, Frati L, Faggioni A
Int J Immunopathol Pharmacol. 2010
PubMed ID: 21244757
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R
Development. 2010
PubMed ID: 20823064
SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway.
Chen P, Huang L, Zhang Y, Qiao M, Yuan Y
Int J Mol Med. 2010
PubMed ID: 20818504
An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K
Hum Genet. 2010
PubMed ID: 20677014
Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction.
Hoefer J, Azam MA, Kroetsch JT, Leong-Poi H, Momen MA, Voigtlaender-Bolz J, Scherer EQ, Meissner A, Bolz SS, Husain M
Circ Res. 2010
PubMed ID: 20671234
Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.
Seong HA, Jung H, Ha H
J Biol Chem. 2010
PubMed ID: 20659902
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation.
Langereis JD, Raaijmakers HA, Ulfman LH, Koenderman L
J Leukoc Biol. 2010
PubMed ID: 20573801
Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17β-estradiol in skeletal muscle cells.
Ronda AC, Buitrago C, Boland R
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20478382
STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis.
O'Kane CM, Elkington PT, Jones MD, Caviedes L, Tovar M, Gilman RH, Stamp G, Friedland JS
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19915152
The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways.
Gao D, Nong S, Huang X, Lu Y, Zhao H, Lin Y, Man Y, Wang S, Yang J, Li J
J Biol Chem. 2010
PubMed ID: 20647313
The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging.
Hsieh CC, Kuro-o M, Rosenblatt KP, Brobey R, Papaconstantinou J
Aging (Albany NY). 2010
PubMed ID: 20844314
Protective effect of P188 in the model of acute trauma to human ankle cartilage: the mechanism of action.
Bajaj S, Shoemaker T, Hakimiyan AA, Rappoport L, Pascual-Garrido C, Oegema TR, Wimmer MA, Chubinskaya S
J Orthop Trauma. 2010
PubMed ID: 20736797
AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK.
Nader N, Ng SS, Lambrou GI, Pervanidou P, Wang Y, Chrousos GP, Kino T
Mol Endocrinol. 2010
PubMed ID: 20660302
Activation of cAMP-responsive-element-binding protein by PI3 kinase and p38 MAPK is essential for elevated expression of transforming growth factor β2 in cancer cells.
Wan Y, Yang M, Kolattukudy S, Stark GR, Lu T
J Interferon Cytokine Res. 2010
PubMed ID: 20629536
Comparative study of p38 MAPK signal transduction pathway of peripheral blood mononuclear cells from patients with coal-combustion-type fluorosis with and without high hair selenium levels.
Chen Q, Wang Z, Xiong Y, Zou X, Liu Z
Int J Hyg Environ Health. 2010
PubMed ID: 20619728
Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation.
Lovett FA, Cosgrove RA, Gonzalez I, Pell JM
Endocrinology. 2010
PubMed ID: 20610565
Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility.
Liu Z, Fan HY, Wang Y, Richards JS
Mol Endocrinol. 2010
PubMed ID: 20610537
Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons.
Chen LJ, Wang YJ, Tseng GF
J Neurotrauma. 2010
PubMed ID: 20568963
beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK.
Mottillo EP, Shen XJ, Granneman JG
Biochim Biophys Acta. 2010
PubMed ID: 20435159
Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.
Liu WH, Chang LS
J Cell Physiol. 2010
PubMed ID: 20432471
A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes.
Nys K, Van Laethem A, Michiels C, Rubio N, Piette JG, Garmyn M, Agostinis P
J Invest Dermatol. 2010
PubMed ID: 20393480
Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.
Coulthard LR, Taylor JC, Eyre S, Biologics in Rheumatoid Arthritis Genetics and Genomics, Robinson JI, Wilson AG, Isaacs JD, Hyrich K, Emery P, Barton A, Barrett JH, Morgan AW, McDermott MF
Ann Rheum Dis. 2010
PubMed ID: 20805296
Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation.
Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H
Mol Cell. 2010
PubMed ID: 20797629
Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation.
Staples CJ, Owens DM, Maier JV, Cato AC, Keyse SM
J Biol Chem. 2010
PubMed ID: 20547488
Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK.
Gasser A, Cheng X, Gilmore ES, Tyrrell L, Waxman SG, Dib-Hajj SD
J Biol Chem. 2010
PubMed ID: 20530479
Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation.
Haines JD, Fang J, Mushynski WE, Almazan G
Glia. 2010
PubMed ID: 20607863
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
Lin MH, Chang KW, Lin SC, Miner JH
Dev Biol. 2010
PubMed ID: 20513444
Mechanisms regulating the nuclear translocation of p38 MAP kinase.
Gong X, Ming X, Deng P, Jiang Y
J Cell Biochem. 2010
PubMed ID: 20506250
Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor.
Cho HJ, Park SM, Hwang EM, Baek KE, Kim IK, Nam IK, Im MJ, Park SH, Bae S, Park JY, Yoo J
J Biol Chem. 2010
PubMed ID: 20558744
Spinal mediators that may contribute selectively to antinociceptive tolerance but not other effects of morphine as revealed by deletion of GluR5.
Gregus AM, Inra CN, Giordano TP, Costa AC, Rajadhyaksha AM, Inturrisi CE
Neuroscience. 2010
PubMed ID: 20359526
Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL
J Biol Chem. 2010
PubMed ID: 20519498
p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells.
Ren Y, Shi Y, Wang Y, Li Y, Wu S, Li H, Zhang Y, Duan H
FEBS Lett. 2010
PubMed ID: 20624390
[Effectiveness of p38MAPK activity during drug resistance against HepG2].
Tang P, Chen WQ, Shen WY
Zhonghua Gan Zang Bing Za Zhi. 2010
PubMed ID: 20825716
Mechanisms and functions of p38 MAPK signalling.
Cuadrado A, Nebreda AR
Biochem J. 2010
PubMed ID: 20626350
Morphine suppresses tumor angiogenesis through a HIF-1alpha/p38MAPK pathway.
Koodie L, Ramakrishnan S, Roy S
Am J Pathol. 2010
PubMed ID: 20616349
The role of the ribosomal protein S19 C-terminus in Gi protein-dependent alternative activation of p38 MAP kinase via the C5a receptor in HMC-1 cells.
Nishiura H, Tokita K, Li Y, Harada K, Woodruff TM, Taylor SM, Nsiama TK, Nishino N, Yamamoto T
Apoptosis. 2010
PubMed ID: 20473571
Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway.
Hsieh MJ, Chen KS, Chiou HL, Hsieh YS
Eur J Cell Biol. 2010
PubMed ID: 20434230
Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells.
Yang TC, Lai CC, Shiu SL, Chuang PH, Tzou BC, Lin YY, Tsai FJ, Lin CW
Microbes Infect. 2010
PubMed ID: 20430109
Sustained expression of NADPH oxidase 4 by p38 MAPK-Akt signaling potentiates radiation-induced differentiation of lung fibroblasts.
Park S, Ahn JY, Lim MJ, Kim MH, Yun YS, Jeong G, Song JY
J Mol Med. 2010
PubMed ID: 20396861
Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity.
Whitehouse CA, Waters S, Marchbank K, Horner A, McGowan NW, Jovanovic JV, Xavier GM, Kashima TG, Cobourne MT, Richards GO, Sharpe PT, Skerry TM, Grigoriadis AE, Solomon E
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20616007
Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa.
Bérubé J, Roussel L, Nattagh L, Rousseau S
J Biol Chem. 2010
PubMed ID: 20460375
Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells.
Vitale I, Jemaà M, Senovilla L, Galluzzi L, Rello-Varona S, Metivier D, Ripoche H, Lazar V, Dessen P, Castedo M, Kroemer G
Cell Cycle. 2010
PubMed ID: 20686359
[Inhibitory effects of melatonin on the expression of phosphorylation p38 mitogen-activated protein kinase during acute lung injury in rats].
Dong YJ, Ding CH, Gu WW, Suo XH
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010
PubMed ID: 20663305
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
Mechanisms of IL-12 synthesis by human dendritic cells treated with the chemical sensitizer NiSO4.
Antonios D, Rousseau P, Larangé A, Kerdine-Römer S, Pallardy M
J Immunol. 2010
PubMed ID: 20525893
Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression.
Noh HJ, Sung EG, Kim JY, Lee TJ, Song IH
Oncol Rep. 2010
PubMed ID: 20514473
P38 mitogen-activated protein kinase activity is required during mitosis for timely satisfaction of the mitotic checkpoint but not for the fidelity of chromosome segregation.
Lee K, Kenny AE, Rieder CL
Mol Biol Cell. 2010
PubMed ID: 20462950
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.
Ordóñez-Morán P, Alvarez-Díaz S, Valle N, Larriba MJ, Bonilla F, Muñoz A
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20223287
SSeCKS promotes tumor necrosis factor-alpha autocrine via activating p38 and JNK pathways in Schwann cells.
Zhou Z, Tao T, Ji Y, Yang H, Wang Y, Cheng C, Shen A, Lu X
Cell Mol Neurobiol. 2010
PubMed ID: 20111901
Over-expression of caveolin-1 aggravate LPS-induced inflammatory response in AT-1 cells via up-regulation of cPLA2/p38 MAPK.
Lv XJ, Li YY, Zhang YJ, Mao M, Qian GS
Inflamm Res. 2010
PubMed ID: 20099006
p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation.
Supinski GS, Ji XY, Callahan LA
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19717815
Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Muñoz-Canoves P, Nebreda AR
EMBO J. 2010
PubMed ID: 20473270
Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways.
Shan L, Redhu NS, Saleh A, Halayko AJ, Chakir J, Gounni AS
J Immunol. 2010
PubMed ID: 20483734
Inhibition of calcium-independent phospholipase A2 activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells.
Sun B, Zhang X, Yonz C, Cummings BS
Biochem Pharmacol. 2010
PubMed ID: 20171194
Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins.
Wong JK, Campbell GR, Spector SA
J Biol Chem. 2010
PubMed ID: 20378550
Krüppel-like factor 4 promotes differentiation by transforming growth factor-beta receptor-mediated Smad and p38 MAPK signaling in vascular smooth muscle cells.
Li HX, Han M, Bernier M, Zheng B, Sun SG, Su M, Zhang R, Fu JR, Wen JK
J Biol Chem. 2010
PubMed ID: 20375011
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
Kang YJ, Otsuka M, van den Berg A, Hong L, Huang Z, Wu X, Zhang DW, Vallance BA, Tobias PS, Han J
PLoS Pathog. 2010
PubMed ID: 20532209
Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro.
Lemoine S, Puddu PE, Durand C, Lepage O, Babatasi G, Ivascau C, Massetti M, Gérard JL, Hanouz JL
Exp Biol Med (Maywood). 2010
PubMed ID: 20511681
Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27.
Fenton RA, Shea LG, Doddi C, Dobson JG
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20363896
MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.
Xu Y, Li F, Zhang B, Zhang K, Zhang F, Huang X, Sun N, Ren Y, Sui M, Liu P
Schizophr Res. 2010
PubMed ID: 20347265
Ketamine reduces inducible superoxide generation in human neutrophils in vitro by modulating the p38 mitogen-activated protein kinase (MAPK)-mediated pathway.
Lu HW, He GN, Ma H, Wang JK
Clin Exp Immunol. 2010
PubMed ID: 20345980
Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease.
Chang KH, de Pablo Y, Lee HP, Lee HG, Smith MA, Shah K
J Neurochem. 2010
PubMed ID: 20345761
The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning.
Sicard P, Clark JE, Jacquet S, Mohammadi S, Arthur JS, O'Keefe SJ, Marber MS
J Mol Cell Cardiol. 2010
PubMed ID: 20188737
Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin.
Huang HM, Li YC, Chung MH
J Cell Physiol. 2010
PubMed ID: 20162623
Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation.
Han Y, Wu G, Deng J, Tao J, Guo L, Tian X, Kang J, Zhang X, Yan C
J Mol Cell Cardiol. 2010
PubMed ID: 20060003
[The role of p38 mitogen-activated protein kinase in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells].
Chu YF, Jiang Y, Zhang JC, Ren HS, Jiang JJ, Meng M, Wang CT
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010
PubMed ID: 20519080
Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway.
Yoon YM, Lee JY, Yoo D, Sim YS, Kim YJ, Oh YK, Kang JS, Kim S, Kim JS, Kim JM
Infect Immun. 2010
PubMed ID: 20231411
Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability.
Frasca D, Romero M, Landin AM, Diaz A, Riley RL, Blomberg BB
Mech Ageing Dev. 2010
PubMed ID: 20219523
DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1.
Mo JS, Jung J, Yoon JH, Hong JA, Kim MY, Ann EJ, Seo MS, Choi YH, Park HS
J Cell Biochem. 2010
PubMed ID: 20213747
p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly.
Khanna P, Yunkunis T, Muddana HS, Peng HH, August A, Dong C
Am J Physiol Cell Physiol. 2010
PubMed ID: 20181932
ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts.
Prasadam I, van Gennip S, Friis T, Shi W, Crawford R, Xiao Y
Arthritis Rheum. 2010
PubMed ID: 20155832
Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration.
Rainey-Smith SR, Andersson DA, Williams RJ, Rattray M
J Neurochem. 2010
PubMed ID: 20132465
Inhibition of centriole duplication by centrobin depletion leads to p38-p53 mediated cell-cycle arrest.
Song L, Dai T, Xiong H, Lin C, Lin H, Shi T, Li J
Cell Signal. 2010
PubMed ID: 20085806
Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta.
Lee WH, Liu FH, Lee YL, Huang HM
J Biochem. 2010
PubMed ID: 20053787
Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells.
Oka S, Kimura S, Toshida T, Ota R, Yamashita A, Sugiura T
J Biochem. 2010
PubMed ID: 20051382
Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.
Ota A, Zhang J, Ping P, Han J, Wang Y
Circ Res. 2010
PubMed ID: 20299663
Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.
Wang L, Gordon RA, Huynh L, Su X, Park Min KH, Han J, Arthur JS, Kalliolias GD, Ivashkiv LB
Immunity. 2010
PubMed ID: 20362473
Hypoxia-induced Bcl-2 expression in endothelial cells via p38 MAPK pathway.
Zhang CL, Song F, Zhang J, Song QH
Biochem Biophys Res Commun. 2010
PubMed ID: 20307495
Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected].
Penzo M, Molteni R, Suda T, Samaniego S, Raucci A, Habiel DM, Miller F, Jiang HP, Li J, Pardi R, Palumbo R, Olivotto E, Kew RR, Bianchi ME, Marcu KB
J Immunol. 2010
PubMed ID: 20231695
Systematic discovery of nonobvious human disease models through orthologous phenotypes.
McGary KL, Park TJ, Woods JO, Cha HJ, Wallingford JB, Marcotte EM
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20308572
[Construction of eukaryotic plasmid expression Hsf4b and phosphorylation of Hsf4b by MAP kinase P38]
Ma ZY, Zhang J, Li XL, Xi ZM, Hu YZ
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010
PubMed ID: 20564821
Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages.
Avni D, Ernst O, Philosoph A, Zor T
Mol Immunol. 2010
PubMed ID: 20303596
Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease.
Otsuka M, Kang YJ, Ren J, Jiang H, Wang Y, Omata M, Han J
Gastroenterology. 2010
PubMed ID: 20080092
Cyclic strain modulates migration and proliferation of vascular smooth muscle cells via Rho-GDIalpha, Rac1, and p38 pathway.
Qi YX, Qu MJ, Yan ZQ, Zhao D, Jiang XH, Shen BR, Jiang ZL
J Cell Biochem. 2010
PubMed ID: 20069557
Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs/p300 and NF-kappaB.
Lee CW, Lee IT, Lin CC, Lee HC, Lin WN, Yang CM
J Cell Biochem. 2010
PubMed ID: 20069553
Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1beta.
Zhang R, Sun L, Hayashi Y, Liu X, Koyama S, Wu Z, Nakanishi H
Neurobiol Dis. 2010
PubMed ID: 20060906
Differential activation of p38MAPK isoforms by MKK6 and MKK3.
Remy G, Risco AM, Iñesta-Vaquera FA, González-Terán B, Sabio G, Davis RJ, Cuenda A
Cell Signal. 2010
PubMed ID: 20004242
The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes.
da Costa SV, Roela RA, Junqueira MS, Arantes C, Brentani MM
Leuk Res. 2010
PubMed ID: 19913910
Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways.
Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JG
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19520919
Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Goldstein DM, Kuglstatter A, Lou Y, Soth MJ
J Med Chem. 2010
PubMed ID: 19950901
p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20212154
p38MAPK signaling and desmoglein-3 internalization are linked events in pemphigus acantholysis.
Jolly PS, Berkowitz P, Bektas M, Lee HE, Chua M, Diaz LA, Rubenstein DS
J Biol Chem. 2010
PubMed ID: 20093368
Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.
Radtke S, Wüller S, Yang XP, Lippok BE, Mütze B, Mais C, de Leur HS, Bode JG, Gaestel M, Heinrich PC, Behrmann I, Schaper F, Hermanns HM
J Cell Sci. 2010
PubMed ID: 20200229
Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras-MKK3-p38 to regulate in vitro cellular invasion.
Behren A, Mühlen S, Acuna Sanhueza GA, Schwager C, Plinkert PK, Huber PE, Abdollahi A, Simon C
Oncogene. 2010
PubMed ID: 20023695
Role of spinal p38alpha and beta MAPK in inflammatory hyperalgesia and spinal COX-2 expression.
Fitzsimmons BL, Zattoni M, Svensson CI, Steinauer J, Hua XY, Yaksh TL
Neuroreport. 2010
PubMed ID: 20134354
TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase.
Su LT, Chen HC, González-Pagán O, Overton JD, Xie J, Yue L, Runnels LW
J Mol Biol. 2010
PubMed ID: 20070945
p38 regulates pigmentation via proteasomal degradation of tyrosinase.
Bellei B, Maresca V, Flori E, Pitisci A, Larue L, Picardo M
J Biol Chem. 2010
PubMed ID: 20053998
p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.
Canault M, Duerschmied D, Brill A, Stefanini L, Schatzberg D, Cifuni SM, Bergmeier W, Wagner DD
Blood. 2010
PubMed ID: 19965619
N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts.
Lu M, Krauss RS
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20160094
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
Millimeter wave treatment inhibits NO-induced apoptosis of chondrocytes through the p38MAPK pathway.
Li X, Du M, Liu X, Wu M, Ye H, Lin J, Chen W, Wu G
Int J Mol Med. 2010
PubMed ID: 20127044
Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.
Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen H, Hancock RE
J Immunol. 2010
PubMed ID: 20107187
p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting.
McClung JM, Judge AR, Powers SK, Yan Z
Am J Physiol Cell Physiol. 2010
PubMed ID: 19955483
P53 and p38 MAPK pathways are involved in MONCPT-induced cell cycle G2/M arrest in human non-small cell lung cancer A549.
Zhang C, Zhu H, Yang X, Lou J, Zhu D, Lu W, He Q, Yang B
J Cancer Res Clin Oncol. 2010
PubMed ID: 19727814
Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.
Xu P, Derynck R
Mol Cell. 2010
PubMed ID: 20188673
Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.
Huang J, Davis EC, Chapman SL, Budatha M, Marmorstein LY, Word RA, Yanagisawa H
Circ Res. 2010
PubMed ID: 20019329
Role of HuR and p38MAPK in ultraviolet B-induced post-transcriptional regulation of COX-2 expression in the human keratinocyte cell line HaCaT.
Fernau NS, Fugmann D, Leyendecker M, Reimann K, Grether-Beck S, Galban S, Ale-Agha N, Krutmann J, Klotz LO
J Biol Chem. 2010
PubMed ID: 19917608
p38alpha is required for ovarian cancer cell metabolism and survival.
Matrone A, Grossi V, Chiacchiera F, Fina E, Cappellari M, Caringella AM, Di Naro E, Loverro G, Simone C
Int J Gynecol Cancer. 2010
PubMed ID: 20169663
The MAP kinase pathway is involved in odontoblast stimulation via p38 phosphorylation.
Simon S, Smith AJ, Berdal A, Lumley PJ, Cooper PR
J Endod. 2010
PubMed ID: 20113784
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt.
Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, Kolch W
Cancer Res. 2010
PubMed ID: 20086174
ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling.
Yong HY, Kim IY, Kim JS, Moon A
Int J Oncol. 2010
PubMed ID: 20043086
Glypican-3 reexpression regulates apoptosis in murine adenocarcinoma mammary cells modulating PI3K/Akt and p38MAPK signaling pathways.
Buchanan C, Stigliano I, Garay-Malpartida HM, Rodrigues Gomes L, Puricelli L, Sogayar MC, Bal de Kier Joffé E, Peters MG
Breast Cancer Res Treat. 2010
PubMed ID: 19288189
A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.
Kumphune S, Bassi R, Jacquet S, Sicard P, Clark JE, Verma S, Avkiran M, O'Keefe SJ, Marber MS
J Biol Chem. 2010
PubMed ID: 19996096
A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway.
Jang ER, Ryu M, Park JE, Kim JH, Lee JS, Song K
J Biol Chem. 2010
PubMed ID: 19948725
Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase.
Hong EH, Lee SJ, Kim JS, Lee KH, Um HD, Kim JH, Kim SJ, Kim JI, Hwang SG
J Biol Chem. 2010
PubMed ID: 19887452
Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP.
Webber JL, Tooze SA
EMBO J. 2010
PubMed ID: 19893488
Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling.
Du CS, Yang RF, Song SW, Wang YP, Kang JH, Zhang R, Su DF, Xie X
Front Pharmacol. 2010
PubMed ID: 21607062
p38 MAPK contributes to the growth inhibition of leukemic tumor cells mediated by human umbilical cord mesenchymal stem cells.
Tian K, Yang S, Ren Q, Han Z, Lu S, Ma F, Zhang L, Han Z
Cell Physiol Biochem. 2010
PubMed ID: 21220911
T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.
Ramgolam VS, DeGregorio SD, Rao GK, Collinge M, Subaran SS, Markovic-Plese S, Pardi R, Bender JR
PLoS One. 2010
PubMed ID: 21206905
p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.
Spallarossa P, Altieri P, Barisione C, Passalacqua M, Aloi C, Fugazza G, Frassoni F, Podestà M, Canepa M, Ghigliotti G, Brunelli C
PLoS One. 2010
PubMed ID: 21187925
Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling.
Marko AJ, Miller RA, Kelman A, Frauwirth KA
PLoS One. 2010
PubMed ID: 21085672
Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity.
Templeton DJ, Aye MS, Rady J, Xu F, Cross JV
PLoS One. 2010
PubMed ID: 21085594
In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase.
Mouchet N, Adamski H, Bouvet R, Corre S, Courbebaisse Y, Watier E, Mosser J, Chesné C, Galibert MD
PLoS One. 2010
PubMed ID: 20505830
REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells.
Bhandari DR, Seo KW, Roh KH, Jung JW, Kang SK, Kang KS
PLoS One. 2010
PubMed ID: 20463961
Dominant negative p38 mitogen-activated protein kinase expression inhibits NF-kappaB activation in AR42J cells.
Twait E, Williard DE, Samuel I
Pancreatology. 2010
PubMed ID: 20453549
PPARgamma2 expression in growth plate chondrocytes is regulated by p38 and GSK-3.
Stanton LA, Li JR, Beier F
J Cell Mol Med. 2010
PubMed ID: 20414969
Cholesterol Perturbation in Mice Results in p53 Degradation and Axonal Pathology through p38 MAPK and Mdm2 Activation.
Qin Q, Liao G, Baudry M, Bi X
PLoS One. 2010
PubMed ID: 20386595
Role of TGF-beta1 and MAP kinases in the antiproliferative effect of aspirin in human vascular smooth muscle cells.
Redondo S, Ruiz E, Gordillo-Moscoso A, Navarro-Dorado J, Ramajo M, Carnero M, Reguillo F, Rodriguez E, Tejerina T
PLoS One. 2010
PubMed ID: 20339548
Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice.
Wang Y, Sun M, Uhlhorn VL, Zhou X, Peter I, Martinez-Abadias N, Hill CA, Percival CJ, Richtsmeier JT, Huso DL, Jabs EW
BMC Dev Biol. 2010
PubMed ID: 20175913
The p38 MAPK regulates IL-24 expression by stabilization of the 3' UTR of IL-24 mRNA.
Otkjaer K, Holtmann H, Kragstrup TW, Paludan SR, Johansen C, Gaestel M, Kragballe K, Iversen L
PLoS One. 2010
PubMed ID: 20072629
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death.
Wang J, Tang R, Lv M, Zhang J, Shen B
Mol Cancer. 2010
PubMed ID: 20070884
Rac/ROS-related protein kinase C and phosphatidylinositol-3-kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated cross-linking of MHC class II molecules.
Yang HY, Kim J, Lee KY, Jang YS
Mol Immunol. 2010
PubMed ID: 19939451
p38 mitogen-activated protein kinase up-regulates NF-kappaB transcriptional activation through RelA phosphorylation during stretch-induced myogenesis.
Ji G, Liu D, Liu J, Gao H, Yuan X, Shen G
Biochem Biophys Res Commun. 2010
PubMed ID: 19931510
Regulation of the intracellular localization of Foxo3a by stress-activated protein kinase signaling pathways in skeletal muscle cells.
Clavel S, Siffroi-Fernandez S, Coldefy AS, Boulukos K, Pisani DF, Dérijard B
Mol Cell Biol. 2010
PubMed ID: 19917721
Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload.
Esposito G, Perrino C, Schiattarella GG, Belardo L, di Pietro E, Franzone A, Capretti G, Gargiulo G, Pironti G, Cannavo A, Sannino A, Izzo R, Chiariello M
Hypertension. 2010
PubMed ID: 19901160
Activation of p38 MAPK pathway by hepatitis C virus E2 in cells transiently expressing DC-SIGN.
Chen QL, Zhu SY, Bian ZQ, Zhao LJ, Cao J, Pan W, Qi ZT
Cell Biochem Biophys. 2010
PubMed ID: 19851890
Early undernutrition increases glycogen content and reduces the activated forms of GSK3, AMPK, p38 MAPK, and JNK in the cerebral cortex of suckling rats.
Lizárraga-Mollinedo E, Fernández-Millán E, de Miguel-Santos L, Martínez-Honduvilla CJ, Alvarez C, Escrivá F
J Neurochem. 2010
PubMed ID: 19840222
p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis.
Gee E, Milkiewicz M, Haas TL
J Cell Physiol. 2010
PubMed ID: 19774558
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy.
Rane MJ, Song Y, Jin S, Barati MT, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein JB, Li X, Cai L
Am J Physiol Renal Physiol. 2010
PubMed ID: 19726550
Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.
Watson JL, Greenshields A, Hill R, Hilchie A, Lee PW, Giacomantonio CA, Hoskin DW
Mol Carcinog. 2010
PubMed ID: 19676105
Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells.
Rubio S, Quintana J, Eiroa JL, Triana J, Estévez F
Mol Carcinog. 2010
PubMed ID: 19676104
The role of p38alpha mitogen-activated protein kinase gene in the HELLP syndrome.
Corradetti A, Saccucci F, Emanuelli M, Vagnoni G, Cecati M, Sartini D, Giannubilo SR, Tranquilli AL
Cell Stress Chaperones. 2010
PubMed ID: 19565356
The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway.
Cheng CC, Wang DY, Kao MH, Chen JK
J Cell Sci. 2009
PubMed ID: 19920075
CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.
Sahay B, Patsey RL, Eggers CH, Salazar JC, Radolf JD, Sellati TJ
PLoS Pathog. 2009
PubMed ID: 20011115
Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells.
Li H, Qi Y, Li C, Braseth LN, Gao Y, Shabashvili AE, Katovich MJ, Sumners C
Mol Cancer Ther. 2009
PubMed ID: 19996275
Induction of matrix metalloproteinase-9 by galectin-7 through p38 MAPK signaling in HeLa human cervical epithelial adenocarcinoma cells.
Park JE, Chang WY, Cho M
Oncol Rep. 2009
PubMed ID: 19885589
Induction of apoptosis in human colon cancer HCT-116 cells by anthocyanins through suppression of Akt and activation of p38-MAPK.
Shin DY, Lee WS, Lu JN, Kang MH, Ryu CH, Kim GY, Kang HS, Shin SC, Choi YH
Int J Oncol. 2009
PubMed ID: 19885574
Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 mAb: implication in chemosensitization.
Vega MI, Martínez-Paniagua M, Huerta-Yepez S, González-Bonilla C, Uematsu N, Bonavida B
Int J Oncol. 2009
PubMed ID: 19885551
Triggering of DC migration by dengue virus stimulation of COX-2-dependent signaling cascades in vitro highlights the significance of these cascades beyond inflammation.
Wu WL, Ho LJ, Chang DM, Chen CH, Lai JH
Eur J Immunol. 2009
PubMed ID: 19862774
p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds.
Li J, Zhao Z, Yang J, Liu J, Wang J, Li X, Liu Y
J Cell Physiol. 2009
PubMed ID: 19725071
IL-17 stimulates migration of carotid artery vascular smooth muscle cells in an MMP-9 dependent manner via p38 MAPK and ERK1/2-dependent NF-kappaB and AP-1 activation.
Cheng G, Wei L, Xiurong W, Xiangzhen L, Shiguang Z, Songbin F
Cell Mol Neurobiol. 2009
PubMed ID: 19404732
Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.
Tiedemann K, Hussein O, Sadvakassova G, Guo Y, Siegel PM, Komarova SV
J Biol Chem. 2009
PubMed ID: 19801662
Cyclin D1 induction by benzo[a]pyrene-7,8-diol-9,10-epoxide via the phosphatidylinositol 3-kinase/Akt/MAPK- and p70s6k-dependent pathway promotes cell transformation and tumorigenesis.
Ding J, Ning B, Gong W, Wen W, Wu K, Liang J, He G, Huang S, Sun W, Han T, Huang L, Cao G, Wu M, Xie W, Wang H
J Biol Chem. 2009
PubMed ID: 19801633
Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway.
Canas PM, Porciúncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, Oliveira CR, Cunha RA
J Neurosci. 2009
PubMed ID: 19940169
Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes.
Oya H, Yokoyama A, Yamaoka I, Fujiki R, Yonezawa M, Youn MY, Takada I, Kato S, Kitagawa H
J Biol Chem. 2009
PubMed ID: 19776015
Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells.
Lee WY, Liu KW, Yeung JH
Cancer Lett. 2009
PubMed ID: 19467570
The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells.
Baan B, van der Zon GC, Maassen JA, Ouwens DM
Mol Cell Endocrinol. 2009
PubMed ID: 19647037
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways.
Nagelin MH, Srinivasan S, Nadler JL, Hedrick CC
J Biol Chem. 2009
PubMed ID: 19713213
Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.
Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ
PLoS Genet. 2009
PubMed ID: 19956733
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Sip1 regulates sequential fate decisions by feedback signaling from postmitotic neurons to progenitors.
Seuntjens E, Nityanandam A, Miquelajauregui A, Debruyn J, Stryjewska A, Goebbels S, Nave KA, Huylebroeck D, Tarabykin V
Nat Neurosci. 2009
PubMed ID: 19838179
Role of p38 MAPK pathway in induction of iNOS expression in neutrophils and peripheral blood mononuclear cells in patients with squamous cell carcinoma of the oral cavity.
Ratajczak-Wrona W, Jablonska E, Marcinczyk M, Grabowska Z, Piotrowski L
J Oral Maxillofac Surg. 2009
PubMed ID: 19837302
The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss.
Böhm C, Hayer S, Kilian A, Zaiss MM, Finger S, Hess A, Engelke K, Kollias G, Krönke G, Zwerina J, Schett G, David JP
J Immunol. 2009
PubMed ID: 19828631
Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury.
Gwak YS, Unabia GC, Hulsebosch CE
Exp Neurol. 2009
PubMed ID: 19699199
MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells.
Wang Y, Weil BR, Herrmann JL, Abarbanell AM, Tan J, Markel TA, Kelly ML, Meldrum DR
Am J Physiol Cell Physiol. 2009
PubMed ID: 19692652
Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK.
Owens TW, Valentijn AJ, Upton JP, Keeble J, Zhang L, Lindsay J, Zouq NK, Gilmore AP
Cell Death Differ. 2009
PubMed ID: 19662026
p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.
Farooq F, Balabanian S, Liu X, Holcik M, MacKenzie A
Hum Mol Genet. 2009
PubMed ID: 19648294
Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning.
Dreixler JC, Barone FC, Shaikh AR, Du E, Roth S
Exp Eye Res. 2009
PubMed ID: 19631642
Pim-3 protects against cardiomyocyte apoptosis in anoxia/reoxygenation injury via p38-mediated signal pathway.
Liu D, He M, Yi B, Guo WH, Que AL, Zhang JX
Int J Biochem Cell Biol. 2009
PubMed ID: 19505587
Astrocytes express Mxi2, a splice isoform of p38MAPK.
Bodega G, Ciordia S, Suárez I, López-Fernández LA, Vacas E, Sánchez-Tejeda G, Albert MA, Juárez S, Albar JP, Fernández B
J Mol Histol. 2009
PubMed ID: 20043236
Caveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell lines.
Han F, Gu D, Chen Q, Zhu H
Pancreas. 2009
PubMed ID: 19893453
beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity.
Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R
Development. 2009
PubMed ID: 19710172
Aberrant integrin activation induces p38 MAPK phosphorylation resulting in suppressed Fas-mediated apoptosis in T cells: implications for rheumatoid arthritis.
Lin YP, Su CC, Huang JY, Lin HC, Cheng YJ, Liu MF, Yang BC
Mol Immunol. 2009
PubMed ID: 19698994
EstA protein, a novel virulence factor of Streptococcus pneumoniae, induces nitric oxide and pro-inflammatory cytokine production in RAW 264.7 macrophages through NF-kappaB/MAPK.
Kang EH, Gebru E, Kim MH, Cheng H, Park SC
Microb Pathog. 2009
PubMed ID: 19596435
Beta-arrestin2 regulates parathyroid hormone effects on a p38 MAPK and NFkappaB gene expression network in osteoblasts.
Bianchi EN, Ferrari SL
Bone. 2009
PubMed ID: 19560570
Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion.
Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD
Cardiovasc Res. 2009
PubMed ID: 19482949
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway.
Kroeger KM, Sullivan BM, Locksley RM
J Leukoc Biol. 2009
PubMed ID: 19451398
Apoptosis induced by modulation in selenium status involves p38 MAPK and ROS: implications in spermatogenesis.
Ranawat P, Bansal MP
Mol Cell Biochem. 2009
PubMed ID: 19363675
Involvement of mitogen-activated protein kinases and nuclear factor kappa B pathways in signaling COX-2 expression in chronic rhinosinusitis.
Wang Z, Zhang Q, Li Y, Li P, Zhang G, Li Y
Inflamm Res. 2009
PubMed ID: 19319478
Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus.
Katoh-Semba R, Kaneko R, Kitajima S, Tsuzuki M, Ichisaka S, Hata Y, Yamada H, Miyazaki N, Takahashi Y, Kato K
Neuroscience. 2009
PubMed ID: 19524026
p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells.
Gaundar SS, Bradstock KF, Bendall LJ
Cell Cycle. 2009
PubMed ID: 19713744
ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury.
Li X, Chaudry IH, Choudhry MA
J Immunol. 2009
PubMed ID: 19710466
miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution.
Carraro G, El-Hashash A, Guidolin D, Tiozzo C, Turcatel G, Young BM, De Langhe SP, Bellusci S, Shi W, Parnigotto PP, Warburton D
Dev Biol. 2009
PubMed ID: 19559694
Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination.
Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A
PLoS Biol. 2009
PubMed ID: 19753101
Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages.
Hardy PO, Diallo TO, Matte C, Descoteaux A
Immunology. 2009
PubMed ID: 19740326
Effect of p38 MAP kinases on contractility and ischemic injury in intact heart.
Cross HR, Li M, Petrich BG, Murphy E, Wang Y, Steenbergen C
Acta Physiol Hung. 2009
PubMed ID: 19706373
Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway.
Peng CL, Guo W, Ji T, Ren T, Yang Y, Li DS, Qu HY, Li X, Tang S, Yan TQ, Tang XD
Cancer Biol Ther. 2009
PubMed ID: 19633425
Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.
Doi T, Adachi S, Takai S, Matsushima-Nishiwaki R, Kato H, Enomoto Y, Minamitani C, Otsuka T, Tokuda H, Akamatsu S, Iwama T, Kozawa O, Ogura S
Arch Biochem Biophys. 2009
PubMed ID: 19631608
Dominant-negative p38alpha mitogen-activated protein kinase prevents cardiac apoptosis and remodeling after streptozotocin-induced diabetes mellitus.
Thandavarayan RA, Watanabe K, Ma M, Gurusamy N, Veeraveedu PT, Konishi T, Zhang S, Muslin AJ, Kodama M, Aizawa Y
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19617408
Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways.
Wanninger J, Neumeier M, Weigert J, Bauer S, Weiss TS, Schäffler A, Krempl C, Bleyl C, Aslanidis C, Schölmerich J, Buechler C
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 19608729
Role of p38 MAPK in burn-induced intestinal barrier breakdown.
Costantini TW, Peterson CY, Kroll L, Loomis WH, Eliceiri BP, Baird A, Bansal V, Coimbra R
J Surg Res. 2009
PubMed ID: 19577248
Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism.
Sharma V, Mustafa S, Patel N, Wambolt R, Allard MF, McNeill JH
Eur J Pharmacol. 2009
PubMed ID: 19573526
Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells.
Jaulmes A, Sansilvestri-Morel P, Rolland-Valognes G, Bernhardt F, Gaertner R, Lockhart BP, Cordi A, Wierzbicki M, Rupin A, Verbeuren TJ
Thromb Res. 2009
PubMed ID: 19540572
Mouse embryonic stem cells lacking p38alpha and p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells.
Chakraborty S, Kang B, Huang F, Guo YL
Differentiation. 2009
PubMed ID: 19539422
Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia.
Morioka N, Tanabe H, Inoue A, Dohi T, Nakata Y
Neurochem Int. 2009
PubMed ID: 19524113
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.
Wang X, Lu Y, Xie B, Cederbaum AI
Free Radic Biol Med. 2009
PubMed ID: 19477265
p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription.
Chiacchiera F, Matrone A, Ferrari E, Ingravallo G, Lo Sasso G, Murzilli S, Petruzzelli M, Salvatore L, Moschetta A, Simone C
Cell Death Differ. 2009
PubMed ID: 19343039
Collagen XVII participates in keratinocyte adhesion to collagen IV, and in p38MAPK-dependent migration and cell signaling.
Qiao H, Shibaki A, Long HA, Wang G, Li Q, Nishie W, Abe R, Akiyama M, Shimizu H, McMillan JR
J Invest Dermatol. 2009
PubMed ID: 19242520
MAPKAPK-2 modulates p38-MAPK localization and small heat shock protein phosphorylation but does not mediate the injury associated with p38-MAPK activation during myocardial ischemia.
Gorog DA, Jabr RI, Tanno M, Sarafraz N, Clark JE, Fisher SG, Cao XB, Bellahcene M, Dighe K, Kabir AM, Quinlan RA, Kato K, Gaestel M, Marber MS, Heads RJ
Cell Stress Chaperones. 2009
PubMed ID: 19214782
The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding.
Bakan A, Bahar I
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706521
Bruceine D induces apoptosis in pancreatic adenocarcinoma cell line PANC-1 through the activation of p38-mitogen activated protein kinase.
Lau ST, Lin ZX, Liao Y, Zhao M, Cheng CH, Leung PS
Cancer Lett. 2009
PubMed ID: 19286308
Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation.
Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RY, Yamashita K
Cancer Res. 2009
PubMed ID: 19638579
Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-alpha and interleukin-8.
Yuan Y, Sun M, Li KS
World J Gastroenterol. 2009
PubMed ID: 19653348
Engulfment of axon debris by microglia requires p38 MAPK activity.
Tanaka T, Ueno M, Yamashita T
J Biol Chem. 2009
PubMed ID: 19531468
p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
Perry JJ, Harris RM, Moiani D, Olson AJ, Tainer JA
J Mol Biol. 2009
PubMed ID: 19501598
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Kim SH, Kim SH, Kim YB, Jeon YT, Lee SC, Song YS
Ann N Y Acad Sci. 2009
PubMed ID: 19723095
Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling.
Kim MS, Kwon JY, Kang NJ, Lee KW, Lee HJ
Ann N Y Acad Sci. 2009
PubMed ID: 19723092
Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells.
Bajbouj K, Poehlmann A, Kuester D, Drewes T, Haase K, Hartig R, Teller A, Kliche S, Walluscheck D, Ivanovska J, Chakilam S, Ulitzsch A, Bommhardt U, Leverkus M, Roessner A, Schneider-Stock R
Am J Pathol. 2009
PubMed ID: 19628771
Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling.
Petrzilka S, Taraborrelli C, Cavadini G, Fontana A, Birchler T
J Biol Rhythms. 2009
PubMed ID: 19625730
Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent phosphatidylinositol 3-kinase activation and increases interleukin-8 production in retinal pigment epithelial cells.
Fernandes AF, Bian Q, Jiang JK, Thomas CJ, Taylor A, Pereira P, Shang F
Mol Biol Cell. 2009
PubMed ID: 19570915
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint.
Lafarga V, Cuadrado A, Lopez de Silanes I, Bengoechea R, Fernandez-Capetillo O, Nebreda AR
Mol Cell Biol. 2009
PubMed ID: 19528229
Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin.
Binion DG, Heidemann J, Li MS, Nelson VM, Otterson MF, Rafiee P
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 19520742
Interferon-alpha2b (IFN-alpha2b)-induced apoptosis is mediated by p38 MAPK in hepatocytes from rat preneoplastic liver via activation of NADPH oxidase.
Quiroga AD, de Lujan Alvarez M, Parody JP, Ronco MT, Carnovale CE, Carrillo MC
Growth Factors. 2009
PubMed ID: 19455458
Rac1 mediates sex difference in cardiac tumor necrosis factor-alpha expression via NADPH oxidase-ERK1/2/p38 MAPK pathway in endotoxemia.
Zhu H, Shan L, Peng T
J Mol Cell Cardiol. 2009
PubMed ID: 19450605
Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling.
Xue A, Xue M, Jackson C, Smith RC
Int J Biochem Cell Biol. 2009
PubMed ID: 19433314
Platelet lysate promotes in vitro wound scratch closure of human dermal fibroblasts: different roles of cell calcium, P38, ERK and PI3K/AKT.
Ranzato E, Mazzucco L, Patrone M, Burlando B
J Cell Mol Med. 2009
PubMed ID: 19267882
Endothelial cell-laminin interaction: modulation of LDH expression involves alpha6beta4 integrin-FAK-p38MAPK pathway.
Sudhakaran PR, Viji RI, Kiran MS, Sameer Kumar VB
Glycoconj J. 2009
PubMed ID: 18814027
Calcium alters monoamine oxidase-A parameters in human cerebellar and rat glial C6 cell extracts: possible influence by distinct signalling pathways.
Cao X, Li XM, Mousseau DD
Life Sci. 2009
PubMed ID: 19539632
Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27.
Garcia MC, Ray DM, Lackford B, Rubino M, Olden K, Roberts JD
J Biol Chem. 2009
PubMed ID: 19506078
Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence.
Adam AP, George A, Schewe D, Bragado P, Iglesias BV, Ranganathan AC, Kourtidis A, Conklin DS, Aguirre-Ghiso JA
Cancer Res. 2009
PubMed ID: 19584293
Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells.
Jin CY, Park C, Kim GY, Lee SJ, Kim WJ, Choi YH
Chem Biol Interact. 2009
PubMed ID: 19497411
Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation.
Corre S, Primot A, Baron Y, Le Seyec J, Goding C, Galibert MD
J Biol Chem. 2009
PubMed ID: 19389701
RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress.
Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, Stocking C, Cameron E, Neil JC
Oncogene. 2009
PubMed ID: 19448675
Regulation of CREB activation by p38 mitogen activated protein kinase during human primary erythroblast differentiation.
Di Giacomo V, Sancilio S, Caravatta L, Rana RA, Di Pietro R, Cataldi A
Int J Immunopathol Pharmacol. 2009
PubMed ID: 19822084
Activation of p38 mitogen-activated protein kinase drives dendritic cells to become tolerogenic in ret transgenic mice spontaneously developing melanoma.
Zhao F, Falk C, Osen W, Kato M, Schadendorf D, Umansky V
Clin Cancer Res. 2009
PubMed ID: 19549770
Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.
Zhen YZ, Lin YJ, Shang BY, Zhen YS
Int J Hematol. 2009
PubMed ID: 19468799
p38 MAP kinase-dependent regulation of the expression level and subcellular distribution of heterogeneous nuclear ribonucleoprotein A1 and its involvement in cellular senescence in normal human fibroblasts.
Shimada N, Rios I, Moran H, Sayers B, Hubbard K
RNA Biol. 2009
PubMed ID: 19430204
Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase.
Chambers MA, Moylan JS, Smith JD, Goodyear LJ, Reid MB
J Physiol. 2009
PubMed ID: 19403598
Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development.
Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HJ, Okano H, Nakayama KI
Mol Cell Biol. 2009
PubMed ID: 19398581
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
alpha1-Adrenergic receptor stimulates interleukin-6 expression and secretion through both mRNA stability and transcriptional regulation: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.
Perez DM, Papay RS, Shi T
Mol Pharmacol. 2009
PubMed ID: 19363165
Activated Ask1-MKK4-p38MAPK/JNK stress signaling pathway in human omental fat tissue may link macrophage infiltration to whole-body Insulin sensitivity.
Blüher M, Bashan N, Shai I, Harman-Boehm I, Tarnovscki T, Avinaoch E, Stumvoll M, Dietrich A, Klöting N, Rudich A
J Clin Endocrinol Metab. 2009
PubMed ID: 19351724
C3G silencing enhances STI-571-induced apoptosis in CML cells through p38 MAPK activation, but it antagonizes STI-571 inhibitory effect on survival.
Maia V, Sanz M, Gutierrez-Berzal J, de Luis A, Gutierrez-Uzquiza A, Porras A, Guerrero C
Cell Signal. 2009
PubMed ID: 19324082
Cytokeratin 19 regulates endoplasmic reticulum stress and inhibits ERp29 expression via p38 MAPK/XBP-1 signaling in breast cancer cells.
Bambang IF, Lu D, Li H, Chiu LL, Lau QC, Koay E, Zhang D
Exp Cell Res. 2009
PubMed ID: 19265690
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway.
Oh JE, Bae GU, Yang YJ, Yi MJ, Lee HJ, Kim BG, Krauss RS, Kang JS
FASEB J. 2009
PubMed ID: 19244314
Candida albicans phospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2.
Li M, Chen Q, Shen Y, Liu W
Exp Dermatol. 2009
PubMed ID: 19196344
The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Ea.hy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway.
Lu ZY, Jensen LE, Huang Y, Kealey C, Blair IA, Whitehead AS
Atherosclerosis. 2009
PubMed ID: 19152916
Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes.
Guner YS, Ochoa CJ, Wang J, Zhang X, Steinhauser S, Stephenson L, Grishin A, Upperman JS
Biochem Biophys Res Commun. 2009
PubMed ID: 19393619
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.
Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, Gaestel M, Blackshear PJ, Clark AR, Saklatvala J, Dean JL
FEBS Lett. 2009
PubMed ID: 19416727
Modulation of p38 MAPK activity in regulatory T cells after tolerance with anti-DNA Ig peptide in (NZB x NZW)F1 lupus mice.
Lourenço EV, Procaccini C, Ferrera F, Iikuni N, Singh RP, Filaci G, Matarese G, Shi FD, Brahn E, Hahn BH, La Cava A
J Immunol. 2009
PubMed ID: 19494264
Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells.
Tanabe K, Nishimura K, Dohi S, Kozawa O
Brain Res. 2009
PubMed ID: 19362079
[Study of the relationship between early growth response gene 1 activity in p38 mitogen-activated protein kinase pathway and epirubicin resistance of human breast carcinoma cells].
Xiao L, Hu JL, Cui W
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 19781349
Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways.
Lim JH, Woo JS, Shin YW
Korean J Intern Med. 2009
PubMed ID: 19543489
Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2.
Naidu S, Vijayan V, Santoso S, Kietzmann T, Immenschuh S
J Immunol. 2009
PubMed ID: 19454702
The adenylyl cyclase-cAMP system suppresses TARC/CCL17 and MDC/CCL22 production through p38 MAPK and NF-kappaB in HaCaT keratinocytes.
Qi XF, Kim DH, Yoon YS, Li JH, Song SB, Jin D, Huang XZ, Teng YC, Lee KJ
Mol Immunol. 2009
PubMed ID: 19371952
Cell density-dependent inhibition of epidermal growth factor receptor signaling by p38alpha mitogen-activated protein kinase via Sprouty2 downregulation.
Swat A, Dolado I, Rojas JM, Nebreda AR
Mol Cell Biol. 2009
PubMed ID: 19364817
Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Kenzel S, Santos-Sierra S, Deshmukh SD, Moeller I, Ergin B, Fitzgerald KA, Lien E, Akira S, Golenbock DT, Henneke P
Infect Immun. 2009
PubMed ID: 19332535
Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms.
Williams DB, Sutherland LN, Bomhof MR, Basaraba SA, Thrush AB, Dyck DJ, Field CJ, Wright DC
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19318515
Short 42 degrees C heat shock induces phosphorylation and degradation of Cdc25A which depends on p38MAPK, Chk2 and 14.3.3.
Madlener S, Rosner M, Krieger S, Giessrigl B, Gridling M, Vo TP, Leisser C, Lackner A, Raab I, Grusch M, Hengstschläger M, Dolznig H, Krupitza G
Hum Mol Genet. 2009
PubMed ID: 19289404
WIN55,212-2 inhibits production of CX3CL1 by human astrocytes: involvement of p38 MAP kinase.
Sheng WS, Hu S, Ni HT, Rock RB, Peterson PK
J Neuroimmune Pharmacol. 2009
PubMed ID: 19214751
Assessing the role of stress signalling via p38 MAP kinase in the premature senescence of ataxia telangiectasia and Werner syndrome fibroblasts.
Davis T, Kipling D
Biogerontology. 2009
PubMed ID: 18830681
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
Hydrostatic pressures promote initial osteodifferentiation with ERK1/2 not p38 MAPK signaling involved.
Liu J, Zhao Z, Li J, Zou L, Shuler C, Zou Y, Huang X, Li M, Wang J
J Cell Biochem. 2009
PubMed ID: 19259952
NADPH oxidase contributes to conversion of cardiac myocytes to a proinflammatory phenotype in sepsis.
Wu J, Xu H, Yang M, Martin CM, Kvietys PR, Rui T
Free Radic Biol Med. 2009
PubMed ID: 19249346
p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047.
Adachi S, Natsume H, Yamauchi J, Matsushima-Nishiwaki R, Joe AK, Moriwaki H, Kozawa O
Cancer Lett. 2009
PubMed ID: 19138820
Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode.
Lin RY, Wang JH, Lu XM, Zhou XT, Mantion G, Wen H, Vuitton DA, Richert L
World J Gastroenterol. 2009
PubMed ID: 19418584
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Effects of hydroxyethyl starch 130/0.4 on P38 mitogen-activated protein kinases signal transduction pathway]
Wang YX, Gao Y, Tian J, Li WW, Wang XR
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009
PubMed ID: 19439112
Induction of Th1 cytokines by Leuconostoc mesenteroides subsp. mesenteroides (KCTC 3100) under Th2-type conditions and the requirement of NF-kappaB and p38/JNK.
Kang H, Myung EJ, Ahn KS, Eom HJ, Han NS, Kim YB, Kim YJ, Sohn NW
Cytokine. 2009
PubMed ID: 19299163
Biphasic activation of p38MAPK suggests that apoptosis is a downstream event in pemphigus acantholysis.
Lee HE, Berkowitz P, Jolly PS, Diaz LA, Chua MP, Rubenstein DS
J Biol Chem. 2009
PubMed ID: 19270308
NRAGE: a potential rheostat during branching morphogenesis.
Nikopoulos GN, Martins JF, Adams TL, Karaczyn A, Adams D, Vary C, Oxburgh L, Verdi JM
Mech Dev. 2009
PubMed ID: 19268530
CD40 and B-cell receptor signalling induce MAPK family members that can either induce or repress Bcl-6 expression.
Batlle A, Papadopoulou V, Gomes AR, Willimott S, Melo JV, Naresh K, Lam EW, Wagner SD
Mol Immunol. 2009
PubMed ID: 19268365
Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation.
Huang M, Kempuraj D, Papadopoulou N, Kourelis T, Donelan J, Manola A, Theoharides TC
J Mol Endocrinol. 2009
PubMed ID: 19211730
Inhibition of p38 MAPK reverses hypoxia-induced pulmonary artery endothelial dysfunction.
Weerackody RP, Welsh DJ, Wadsworth RM, Peacock AJ
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19201999
Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway.
Zhang Y, Herbert BS, Rajashekhar G, Ingram DA, Yoder MC, Clauss M, Rehman J
FASEB J. 2009
PubMed ID: 19124561
Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation.
Chen C, Wang Y, Zhang Z, Wang C, Peng M
Shock. 2009
PubMed ID: 18827744
p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.
Kwong J, Hong L, Liao R, Deng Q, Han J, Sun P
J Biol Chem. 2009
PubMed ID: 19251701
Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells.
Li X, Rong Y, Zhang M, Wang XL, LeMaire SA, Coselli JS, Zhang Y, Shen YH
Biochem Biophys Res Commun. 2009
PubMed ID: 19254690
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
J Biol Chem. 2009
PubMed ID: 19224920
ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: the roles of P2X4 receptors and p38 MAPK in microglia.
Gong QJ, Li YY, Xin WJ, Zang Y, Ren WJ, Wei XH, Li YY, Zhang T, Liu XG
Glia. 2009
PubMed ID: 18837052
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
Blood. 2009
PubMed ID: 19129540
Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice.
Seimon TA, Wang Y, Han S, Senokuchi T, Schrijvers DM, Kuriakose G, Tall AR, Tabas IA
J Clin Invest. 2009
PubMed ID: 19287091
Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma.
Seo JY, Kim DY, Lee YS, Ro JY
Cytokine. 2009
PubMed ID: 19231233
Inhibitory effect of ZPDC glycoprotein on the expression of inflammation-related cytokines through p38 MAP kinase and JNK in lipopolysaccharide-stimulated RAW 264.7 cells.
Lee SJ, Lim KT
Inflamm Res. 2009
PubMed ID: 19214384
Arachidonic acid release by H2O2 mediated proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation.
Lee SH, Na SI, Heo JS, Kim MH, Kim YH, Lee MY, Kim SH, Lee YJ, Han HJ
J Cell Biochem. 2009
PubMed ID: 19199341
p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles.
Curtis AM, Wilkinson PF, Gui M, Gales TL, Hu E, Edelberg JM
J Thromb Haemost. 2009
PubMed ID: 19192109
Crucial implication of protein kinase C (PKC)-delta, PKC-zeta, ERK-1/2, and p38 MAPK in migration of human asthmatic eosinophils.
Langlois A, Chouinard F, Flamand N, Ferland C, Rola-Pleszczynski M, Laviolette M
J Leukoc Biol. 2009
PubMed ID: 19164129
Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis.
Marchant D, Dou Y, Luo H, Garmaroudi FS, McDonough JE, Si X, Walker E, Luo Z, Arner A, Hegele RG, Laher I, McManus BM
Circ Res. 2009
PubMed ID: 19213955
p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180.
Askari N, Beenstock J, Livnah O, Engelberg D
Biochemistry. 2009
PubMed ID: 19209848
Role of Src signal transduction pathways in scatter factor-mediated cellular protection.
Fan S, Meng Q, Laterra JJ, Rosen EM
J Biol Chem. 2009
PubMed ID: 19047046
Distinct roles of stress-activated protein kinases in Fanconi anemia-type C-deficient hematopoiesis.
Saadatzadeh MR, Bijangi-Vishehsaraei K, Kapur R, Haneline LS
Blood. 2009
PubMed ID: 19168785
GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.
Zhong J, Gavrilescu LC, Molnár A, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19246396
The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation.
Hallé M, Gomez MA, Stuible M, Shimizu H, McMaster WR, Olivier M, Tremblay ML
J Biol Chem. 2009
PubMed ID: 19064994
Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway.
Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK
Cancer Lett. 2009
PubMed ID: 19010591
Nox4 overexpression activates reactive oxygen species and p38 MAPK in human endothelial cells.
Goettsch C, Goettsch W, Muller G, Seebach J, Schnittler HJ, Morawietz H
Biochem Biophys Res Commun. 2009
PubMed ID: 19280689
p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.
Tan M, Walwyn WM, Evans CJ, Xie CW
J Biol Chem. 2009
PubMed ID: 19126537
Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.
Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD
Blood. 2009
PubMed ID: 19011223
Endotoxin tolerance of RAW264.7 correlates with p38-dependent up-regulation of scavenger receptor-A.
Xiang Q, Wen L, Liu MH, Zhang Y, Qu JF, Tian J
J Int Med Res. 2009
PubMed ID: 19383244
p38 MAPK regulates ischemia-reperfusion-induced recruitment of leukocytes in the colon.
Santén S, Mihaescu A, Laschke MW, Menger MD, Wang Y, Jeppsson B, Thorlacius H
Surgery. 2009
PubMed ID: 19231583
Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanism.
Yusof M, Kamada K, Kalogeris T, Gaskin FS, Korthuis RJ
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19168723
4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase.
Yun MR, Im DS, Lee SJ, Park HM, Bae SS, Lee WS, Kim CD
Free Radic Biol Med. 2009
PubMed ID: 19135147
Signalling pathway involving GULP, MAPK and Rac1 for SR-BI-induced phagocytosis of apoptotic cells.
Osada Y, Sunatani T, Kim IS, Nakanishi Y, Shiratsuchi A
J Biochem. 2009
PubMed ID: 19122200
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle.
Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M
J Appl Physiol. 2009
PubMed ID: 19112161
JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia.
Peng T, Zhang T, Lu X, Feng Q
Cardiovasc Res. 2009
PubMed ID: 19043087
Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3.
Lu T, Huang CC, Lu YC, Lin KL, Liu SI, Wang BW, Chang PM, Chen IS, Chen SS, Tsai JY, Chou CT, Jan CR
Clin Exp Pharmacol Physiol. 2009
PubMed ID: 18986328
Spinal p38 mitogen-activated protein kinase mediates allodynia induced by first-degree burn in the rat.
Sorkin L, Svensson CI, Jones-Cordero TL, Hefferan MP, Campana WM
J Neurosci Res. 2009
PubMed ID: 18855936
Acute adrenergic stress inhibits proliferation of murine hematopoietic progenitor cells via p38/MAPK signaling.
Schraml E, Fuchs R, Kotzbeck P, Grillari J, Schauenstein K
Stem Cells Dev. 2009
PubMed ID: 18444787
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR
Circ Res. 2009
PubMed ID: 19122179
PPARdelta agonist-mediated ROS stimulates mouse embryonic stem cell proliferation through cooperation of p38 MAPK and Wnt/beta-catenin.
Jeong AY, Lee MY, Lee SH, Park JH, Han HJ
Cell Cycle. 2009
PubMed ID: 19197156
Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of
Li H, Mittal A, Paul PK, Kumar M, Srivastava DS, Tyagi SC, Kumar A
J Biol Chem. 2009
PubMed ID: 19074147
Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB.
Wang C, Chen T, Zhang N, Yang M, Li B, Lü X, Cao X, Ling C
J Biol Chem. 2009
PubMed ID: 19074436
Dendritic cells contribute to autoimmune kidney injury in MRL-Faslpr mice.
Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Zhou H, Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I, Matsushima K, Kaneko S, Wada T
J Rheumatol. 2009
PubMed ID: 19208562
Effect of ultraviolet radiation on the expression of pp38MAPK and furin in human keratinocyte-derived cell lines.
Huynh TT, Chan KS, Piva TJ
Photodermatol Photoimmunol Photomed. 2009
PubMed ID: 19152512
Roles of Cx43-associated protein kinases in suppression of gap junction-mediated chemical coupling by ischemic preconditioning.
Naitoh K, Yano T, Miura T, Itoh T, Miki T, Tanno M, Sato T, Hotta H, Terashima Y, Shimamoto K
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19098115
Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells.
Ignatova ID, Kostadinova RM, Goldring CE, Nawrocki AR, Frey FJ, Frey BM
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19088256
Herpes simplex virus type 1 ICP27 induces p38 mitogen-activated protein kinase signaling and apoptosis in HeLa cells.
Gillis PA, Okagaki LH, Rice SA
J Virol. 2009
PubMed ID: 19073744
Role of MKK3-p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice.
Lim AK, Nikolic-Paterson DJ, Ma FY, Ozols E, Thomas MC, Flavell RA, Davis RJ, Tesch GH
Diabetologia. 2009
PubMed ID: 19066844
Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes.
McAlees JW, Sanders VM
Mol Cell Biol. 2009
PubMed ID: 19047375
LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.
Anand AR, Bradley R, Ganju RK
Mol Immunol. 2009
PubMed ID: 18954908
Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38.
Park SH, Kim KY, An BS, Choi JH, Jeung EB, Leung PC, Choi KC
J Reprod Dev. 2009
PubMed ID: 18854640
IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance.
Goleva E, Li LB, Leung DY
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18776133
Evidence that Fgf10 contributes to the skeletal and visceral defects of an apert syndrome mouse model.
Hajihosseini MK, Duarte R, Pegrum J, Donjacour A, Lana-Elola E, Rice DP, Sharpe J, Dickson C
Dev Dyn. 2009
PubMed ID: 18773495
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway.
Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, Du X
Blood. 2009
PubMed ID: 18957688
Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK.
Hui KP, Lee SM, Cheung CY, Ng IH, Poon LL, Guan Y, Ip NY, Lau AS, Peiris JS
J Immunol. 2009
PubMed ID: 19124752
Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.
Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, Zhang H, Berthet C, Nagashim K, Veenstra TK, Tessarollo L, Acharya U, Acharya JK
J Cell Biol. 2009
PubMed ID: 19139267
Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation.
Ivanova IA, Nakrieko KA, Dagnino L
Oncogene. 2009
PubMed ID: 18794805
A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters.
Bruck N, Vitoux D, Ferry C, Duong V, Bauer A, de Thé H, Rochette-Egly C
EMBO J. 2009
PubMed ID: 19078967
Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer.
Lee KH, Kim JR
Oncol Res. 2009
PubMed ID: 20066900
Fas-induced apoptosis of renal cell carcinoma is mediated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation.
Hassan M, Feyen O, Grinstein E
Cell Oncol. 2009
PubMed ID: 19940360
p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.
Pogozelski AR, Geng T, Li P, Yin X, Lira VA, Zhang M, Chi JT, Yan Z
PLoS One. 2009
PubMed ID: 19936205
Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.
Wang P, Yu P, Gao P, Shi T, Ma D
BMC Genomics. 2009
PubMed ID: 19906316
The proliferation and migration effects of huangqi on RSC96 Schwann cells.
Fang WK, Ko FY, Wang HL, Kuo CH, Chen LM, Tsai FJ, Tsai CH, Chen YS, Kuo WW, Huang CY
Am J Chin Med. 2009
PubMed ID: 19885954
Genetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism
BMC Biol. 2009
PubMed ID: 19874574
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase.
Park DW, Choi KC, MacCalman CD, Leung PC
Reprod Biol Endocrinol. 2009
PubMed ID: 19656390
Advanced glycation end products induce calcification of vascular smooth muscle cells through RAGE/p38 MAPK.
Tanikawa T, Okada Y, Tanikawa R, Tanaka Y
J Vasc Res. 2009
PubMed ID: 19571577
mCD14 expression in human monocytes is downregulated by ouabain via transactivation of epithelial growth factor receptor and activation of p38 mitogen-activated protein kinase.
Valente RC, Nascimento CR, Araujo EG, Rumjanek VM
Neuroimmunomodulation. 2009
PubMed ID: 19365146
The pivotal role of p38 and NF-kappaB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432.
Pan K, Wang H, Liu WL, Zhang HK, Zhou J, Li JJ, Weng DS, Huang W, Sun JC, Liang XT, Xia JC
Immunobiology. 2009
PubMed ID: 19362680
[Expression of p38MAPK in the olfactory bulb of rats with Alzheimer's disease]
Zhang GL, Du Y, Yao L, Zhang R, Liu JJ, Bu N, Yuan HF, Wu HQ
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19292041
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
Alavian KN, Sgadò P, Alberi L, Subramaniam S, Simon HH
Neural Dev. 2009
PubMed ID: 19291307
Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury.
Damarla M, Hasan E, Boueiz A, Le A, Pae HH, Montouchet C, Kolb T, Simms T, Myers A, Kayyali US, Gaestel M, Peng X, Reddy SP, Damico R, Hassoun PM
PLoS One. 2009
PubMed ID: 19240800
p38 MAPK contributes to CD54 expression and the enhancement of phagocytic activity during macrophage development.
Cui J, Zhu N, Wang Q, Yu M, Feng J, Li Y, Zhang J, Shen B
Cell Immunol. 2009
PubMed ID: 19185295
p38 MAPK contributes to angiotensin II-induced COX-2 expression in aortic fibroblasts from normotensive and hypertensive rats.
Beltrán AE, Briones AM, García-Redondo AB, Rodríguez C, Miguel M, Alvarez Y, Alonso MJ, Martínez-González J, Salaices M
J Hypertens. 2009
PubMed ID: 19145780
Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression.
Flacke JP, Kumar S, Kostin S, Reusch HP, Ladilov Y
Apoptosis. 2009
PubMed ID: 19082728
Inhibition of allograft inflammatory factor-1 expression reduces development of neointimal hyperplasia and p38 kinase activity.
Sommerville LJ, Xing C, Kelemen SE, Eguchi S, Autieri MV
Cardiovasc Res. 2009
PubMed ID: 18779232
LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase.
Bulat N, Waeber G, Widmann C
J Lipid Res. 2009
PubMed ID: 18757346
GluR6-containing KA receptor mediates the activation of p38 MAP kinase in rat hippocampal CA1 region during brain ischemia injury.
Chen J, Li C, Pei DS, Han D, Liu XM, Jiang HX, Wang XT, Guan QH, Wen XR, Hou XY, Zhang GY
Hippocampus. 2009
PubMed ID: 18680160
The role of P38 MAPK and PKC in BLP induced TNF-alpha release, apoptosis, and NFkappaB activation in THP-1 monocyte cells.
O'Sullivan AW, Wang JH, Redmond HP
J Surg Res. 2009
PubMed ID: 18675993
Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation.
Xia M, Ling W, Zhu H, Ma J, Wang Q, Hou M, Tang Z, Guo H, Liu C, Ye Q
Atherosclerosis. 2009
PubMed ID: 18495129
Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells.
Lee YM, Lee JO, Jung JH, Kim JH, Park SH, Park JM, Kim EK, Suh PG, Kim HS
J Biol Chem. 2008
PubMed ID: 18927084
Leukocyte antigen-related protein tyrosine phosphatase negatively regulates hydrogen peroxide-induced vascular smooth muscle cell apoptosis.
Li J, Niu XL, Madamanchi NR
J Biol Chem. 2008
PubMed ID: 18854310
c-Src-p38 mitogen-activated protein kinase signaling is required for Akt activation in response to ionizing radiation.
Kim MJ, Byun JY, Yun CH, Park IC, Lee KH, Lee SJ
Mol Cancer Res. 2008
PubMed ID: 19074832
Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin.
Berkowitz P, Chua M, Liu Z, Diaz LA, Rubenstein DS
Am J Pathol. 2008
PubMed ID: 18988808
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade.
Mandal C, Dutta A, Mallick A, Chandra S, Misra L, Sangwan RS, Mandal C
Apoptosis. 2008
PubMed ID: 18987975
Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: opposing roles of JNK1/2 and p38alpha MAP kinases.
Lal H, Verma SK, Golden HB, Foster DM, Smith M, Dostal DE
J Mol Cell Cardiol. 2008
PubMed ID: 18926830
CXCR4 receptor antagonist blocks cardiac myocyte p38 MAP kinase phosphorylation by HIV gp120.
Yuan Y, Kan H, Fang Q, Chen F, Finkel MS
Cardiovasc Toxicol. 2008
PubMed ID: 18850076
o,p'-DDT induces cyclooxygenase-2 gene expression in murine macrophages: Role of AP-1 and CRE promoter elements and PI3-kinase/Akt/MAPK signaling pathways.
Han EH, Kim JY, Kim HK, Hwang YP, Jeong HG
Toxicol Appl Pharmacol. 2008
PubMed ID: 18840457
Vesicular stomatitis virus matrix protein impairs CD1d-mediated antigen presentation through activation of the p38 MAPK pathway.
Renukaradhya GJ, Khan MA, Shaji D, Brutkiewicz RR
J Virol. 2008
PubMed ID: 18815300
Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism.
Muthumani K, Choo AY, Shedlock DJ, Laddy DJ, Sundaram SG, Hirao L, Wu L, Thieu KP, Chung CW, Lankaraman KM, Tebas P, Silvestri G, Weiner DB
J Virol. 2008
PubMed ID: 18799583
AUF1 is upregulated by angiotensin II to destabilize cardiac Kv4.3 channel mRNA.
Zhou C, Vignere CZ, Levitan ES
J Mol Cell Cardiol. 2008
PubMed ID: 18789946
Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.
Sauvant C, Nowak M, Wirth C, Schneider B, Riemann A, Gekle M, Thews O
Int J Cancer. 2008
PubMed ID: 18729196
Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation.
Lambert S, Ameels H, Gniadecki R, Hérin M, Poumay Y
J Cell Physiol. 2008
PubMed ID: 18727093
TGF-beta induces connexin43 gene expression in normal murine mammary gland epithelial cells via activation of p38 and PI3K/AKT signaling pathways.
Tacheau C, Fontaine J, Loy J, Mauviel A, Verrecchia F
J Cell Physiol. 2008
PubMed ID: 18668519
The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation.
Zhao Q, Barakat BM, Qin S, Ray A, El-Mahdy MA, Wani G, Arafa el-S, Mir SN, Wang QE, Wani AA
J Biol Chem. 2008
PubMed ID: 18806262
Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.
Karunakaran S, Saeed U, Mishra M, Valli RK, Joshi SD, Meka DP, Seth P, Ravindranath V
J Neurosci. 2008
PubMed ID: 19020042
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.
Ordóñez-Morán P, Larriba MJ, Pálmer HG, Valero RA, Barbáchano A, Duñach M, de Herreros AG, Villalobos C, Berciano MT, Lafarga M, Muñoz A
J Cell Biol. 2008
PubMed ID: 19015318
Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.
Balloy V, Sallenave JM, Wu Y, Touqui L, Latgé JP, Si-Tahar M, Chignard M
J Biol Chem. 2008
PubMed ID: 18703508
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila.
Shin S, Case CL, Archer KA, Nogueira CV, Kobayashi KS, Flavell RA, Roy CR, Zamboni DS
PLoS Pathog. 2008
PubMed ID: 19043549
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M, Kageyama R, Ivashkiv LB
Immunity. 2008
PubMed ID: 18976936
Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity.
Kim JE, Jin DH, Lee SD, Hong SW, Shin JS, Lee SK, Jung DJ, Kang JS, Lee WJ
Int J Mol Med. 2008
PubMed ID: 18949386
Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.
Kawahara K, Hashiguchi T, Kikuchi K, Tancharoen S, Miura N, Ito T, Oyama Y, Nawa Y, Biswas KK, Meng X, Morimoto Y, Shrestha B, Sameshima H, Maruyama I
Int J Mol Med. 2008
PubMed ID: 18949384
p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta.
Bikkavilli RK, Feigin ME, Malbon CC
J Cell Sci. 2008
PubMed ID: 18946023
Basal and IGF-I-dependent regulation of potassium channels by MAP kinases and PI3-kinase during eccentric cardiac hypertrophy.
Teos LY, Zhao A, Alvin Z, Laurence GG, Li C, Haddad GE
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18757484
ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.
Densham RM, Todd DE, Balmanno K, Cook SJ
Cell Signal. 2008
PubMed ID: 18664382
Initiation of caspase-independent death in mouse mesangial cells by Cd2+: involvement of p38 kinase and CaMK-II.
Liu Y, Templeton DM
J Cell Physiol. 2008
PubMed ID: 18506790
15-deoxy-Delta(12,14)-prostaglandin J2 induces vascular endothelial cell apoptosis through the sequential activation of MAPKS and p53.
Ho TC, Chen SL, Yang YC, Chen CY, Feng FP, Hsieh JW, Cheng HC, Tsao YP
J Biol Chem. 2008
PubMed ID: 18718914
Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway.
Wu SC, Chang SC, Wu HY, Liao PJ, Chang MF
J Biol Chem. 2008
PubMed ID: 18728014
Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes.
Scott MJ, Billiar TR
J Biol Chem. 2008
PubMed ID: 18701460
A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors.
Gong K, Li Z, Xu M, Du J, Lv Z, Zhang Y
J Biol Chem. 2008
PubMed ID: 18678875
IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation.
Valledor AF, Arpa L, Sánchez-Tilló E, Comalada M, Casals C, Xaus J, Caelles C, Lloberas J, Celada A
Blood. 2008
PubMed ID: 18682602
FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice.
Nishimura T, Andoh A, Nishida A, Shioya M, Koizumi Y, Tsujikawa T, Fujiyama Y
World J Gastroenterol. 2008
PubMed ID: 18855984
Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.
Szokodi I, Kerkelä R, Kubin AM, Sármán B, Pikkarainen S, Kónyi A, Horváth IG, Papp L, Tóth M, Skoumal R, Ruskoaho H
Circulation. 2008
PubMed ID: 18824646
Histamine induces Egr-1 expression in human aortic endothelial cells via the H1 receptor-mediated protein kinase Cdelta-dependent ERK activation pathway.
Hao F, Tan M, Xu X, Cui MZ
J Biol Chem. 2008
PubMed ID: 18682391
Hypoxia induces discoidin domain receptor-2 expression via the p38 pathway in vascular smooth muscle cells to increase their migration.
Chen SC, Wang BW, Wang DL, Shyu KG
Biochem Biophys Res Commun. 2008
PubMed ID: 18664364
Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways.
Iwai T, Murai J, Yoshikawa H, Tsumaki N
J Biol Chem. 2008
PubMed ID: 18644788
Inhibition of p38alpha MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment.
Navas T, Zhou L, Estes M, Haghnazari E, Nguyen AN, Mo Y, Pahanish P, Mohindru M, Cao T, Higgins LS, Platanias LC, List A, Verma A
Leuk Lymphoma. 2008
PubMed ID: 18949619
A potential role of connexin 43 in epidermal growth factor-induced proliferation of mouse embryonic stem cells: involvement of Ca2+/PKC, p44/42 and p38 MAPKs pathways.
Park JH, Lee MY, Heo JS, Han HJ
Cell Prolif. 2008
PubMed ID: 18823499
p28GANK knockdown-derived reactive oxygen species induces apoptosis through mitochondrial dysfunction mediated by p38 in HepG2 cells.
Wang X, Li H, Chen Y, Fu J, Ren Y, Dong L, Tang S, Liu S, Wu M, Wang H
Int J Oncol. 2008
PubMed ID: 18813787
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
Sorrentino A, Thakur N, Grimsby S, Marcusson A, von Bulow V, Schuster N, Zhang S, Heldin CH, Landström M
Nat Cell Biol. 2008
PubMed ID: 18758450
Borrelia burgdorferi lipoprotein BmpA activates pro-inflammatory responses in human synovial cells through a protein moiety.
Yang X, Izadi H, Coleman AS, Wang P, Ma Y, Fikrig E, Anguita J, Pal U
Microbes Infect. 2008
PubMed ID: 18725314
p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.
Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR, Pasparakis M
EMBO Rep. 2008
PubMed ID: 18704119
Ouabain inhibits p38 activation in thymocytes.
Rodrigues-Mascarenhas S, Bloise FF, Moscat J, Rumjanek VM
Cell Biol Int. 2008
PubMed ID: 18703152
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M
Gastroenterology. 2008
PubMed ID: 18700144
Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis.
Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C
Dev Biol. 2008
PubMed ID: 18692041
Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury.
Le A, Damico R, Damarla M, Boueiz A, Pae HH, Skirball J, Hasan E, Peng X, Chesley A, Crow MT, Reddy SP, Tuder RM, Hassoun PM
J Appl Physiol. 2008
PubMed ID: 18669934
Phosphodiesterase-5 inhibition abolishes neuron apoptosis induced by chronic hypoxia independently of hypoxia-inducible factor-1alpha signaling.
Caretti A, Bianciardi P, Ronchi R, Fantacci M, Guazzi M, Samaja M
Exp Biol Med (Maywood). 2008
PubMed ID: 18641057
NF-kappaB, but not p38 MAP kinase, is required for TNF-alpha-induced expression of cell adhesion molecules in endothelial cells.
Rajan S, Ye J, Bai S, Huang F, Guo YL
J Cell Biochem. 2008
PubMed ID: 18613029
Activation of p38 MAP kinase is involved in central neuropathic pain following spinal cord injury.
Crown ED, Gwak YS, Ye Z, Johnson KM, Hulsebosch CE
Exp Neurol. 2008
PubMed ID: 18590729
Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion.
Nito C, Kamada H, Endo H, Niizuma K, Myer DJ, Chan PH
J Cereb Blood Flow Metab. 2008
PubMed ID: 18545259
Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels.
Hsu JT, Kan WH, Hsieh YC, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
Shock. 2008
PubMed ID: 18277950
TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta.
Yamashita M, Fatyol K, Jin C, Wang X, Liu Z, Zhang YE
Mol Cell. 2008
PubMed ID: 18922473
Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong le A, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO, Evans PC
Circ Res. 2008
PubMed ID: 18723442
Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states.
Zhang YY, Mei ZQ, Wu JW, Wang ZX
J Biol Chem. 2008
PubMed ID: 18669639
ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7.
Im JS, Lee JK
J Biol Chem. 2008
PubMed ID: 18625709
Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis.
Wang WH, Hullinger RL, Andrisani OM
J Biol Chem. 2008
PubMed ID: 18606816
Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Minamitani C, Otsuka T, Takai S, Matsushima-Nishiwaki R, Adachi S, Hanai Y, Mizutani J, Tokuda H, Kozawa O
Mol Cell Endocrinol. 2008
PubMed ID: 18586382
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.
Chan PM, Lim L, Manser E
J Biol Chem. 2008
PubMed ID: 18586681
[Effect of p38 mitogen-activated protein kinase gene knockout on cell proliferation of embryonic fibroblasts in mice]
Gong XW, Wei J, Li YS, Cheng WW, Deng P, Jiang Y
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008
PubMed ID: 18786310
Role of p38 MAPK and JNK in enhanced cervical cancer cell killing by the combination of arsenic trioxide and ionizing radiation.
Kang YH, Lee SJ
Oncol Rep. 2008
PubMed ID: 18695917
The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression.
Kim C, Sano Y, Todorova K, Carlson BA, Arpa L, Celada A, Lawrence T, Otsu K, Brissette JL, Arthur JS, Park JM
Nat Immunol. 2008
PubMed ID: 18677317
Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7.
Oshima T, Miwa H, Joh T
Am J Physiol Cell Physiol. 2008
PubMed ID: 18667601
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Grhl3 and Lmo4 play coordinate roles in epidermal migration.
Hislop NR, Caddy J, Ting SB, Auden A, Vasudevan S, King SL, Lindeman GJ, Visvader JE, Cunningham JM, Jane SM
Dev Biol. 2008
PubMed ID: 18619436
Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain.
Qu MJ, Liu B, Qi YX, Jiang ZL
Ann Biomed Eng. 2008
PubMed ID: 18566890
Thymulin inhibits monocrotaline-induced pulmonary hypertension modulating interleukin-6 expression and suppressing p38 pathway.
Henriques-Coelho T, Oliveira SM, Moura RS, Roncon-Albuquerque R, Neves AL, Santos M, Nogueira-Silva C, La Fuente Carvalho F, Brandão-Nogueira A, Correia-Pinto J, Leite-Moreira AF
Endocrinology. 2008
PubMed ID: 18511508
Bcl2, a transcriptional target of p38alpha, is critical for neuronal commitment of mouse embryonic stem cells.
Trouillas M, Saucourt C, Duval D, Gauthereau X, Thibault C, Dembele D, Feraud O, Menager J, Rallu M, Pradier L, Boeuf H
Cell Death Differ. 2008
PubMed ID: 18437159
Artepillin C derived from propolis induces neurite outgrowth in PC12m3 cells via ERK and p38 MAPK pathways.
Kano Y, Horie N, Doi S, Aramaki F, Maeda H, Hiragami F, Kawamura K, Motoda H, Koike Y, Akiyama J, Eguchi S, Hashimoto K
Neurochem Res. 2008
PubMed ID: 18338254
ATF-1 is a hypoxia-responsive transcriptional activator of skeletal muscle mitochondrial-uncoupling protein 3.
Lu Z, Sack MN
J Biol Chem. 2008
PubMed ID: 18579531
Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis.
Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M
Cancer Cell. 2008
PubMed ID: 18691550
A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation.
Kang JS, Bae GU, Yi MJ, Yang YJ, Oh JE, Takaesu G, Zhou YT, Low BC, Krauss RS
J Cell Biol. 2008
PubMed ID: 18678706
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway.
Lu C, Shi Y, Wang Z, Song Z, Zhu M, Cai Q, Chen T
FEBS Lett. 2008
PubMed ID: 18619440
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury.
Proctor BM, Jin X, Lupu TS, Muglia LJ, Semenkovich CF, Muslin AJ
Circulation. 2008
PubMed ID: 18645058
Mitogen-activated protein kinase regulates FSH-induced expression of tissue-type plasminogen activator through an activator protein 1 response element.
Yang W, Lu CL, Yu FQ, Liu T, Hu ZY, Liu YX
Endocrine. 2008
PubMed ID: 18982462
Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development.
Xu X, Han J, Ito Y, Bringas P, Deng C, Chai Y
Dev Cell. 2008
PubMed ID: 18694570
Severe acute respiratory syndrome coronavirus 3a protein activates the mitochondrial death pathway through p38 MAP kinase activation.
Padhan K, Minakshi R, Towheed MA, Jameel S
J Gen Virol. 2008
PubMed ID: 18632968
Upregulation of annexin A1 expression by butyrate in human colon adenocarcinoma cells: role of p53, NF-Y, and p38 mitogen-activated protein kinase.
Lecona E, Barrasa JI, Olmo N, Llorente B, Turnay J, Lizarbe MA
Mol Cell Biol. 2008
PubMed ID: 18541673
Suppression of p38-stress kinase sensitizes quiescent leukemic cells to anti-mitotic drugs by inducing proliferative responses in them.
Vaidya AA, Sharma MB, Kale VP
Cancer Biol Ther. 2008
PubMed ID: 18487954
Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases.
LaMarca HL, Dash PR, Vishnuthevan K, Harvey E, Sullivan DE, Morris CA, Whitley GS
Hum Reprod. 2008
PubMed ID: 18487214
Involvement of p38MAPK and reactive oxygen species in icariin-induced cardiomyocyte differentiation of murine embryonic stem cells in vitro.
Ding L, Liang XG, Hu Y, Zhu DY, Lou YJ
Stem Cells Dev. 2008
PubMed ID: 18484897
Inhibitors of p38 mitogen-activated protein kinase enhance proliferation of mouse neural stem cells.
Sato K, Hamanoue M, Takamatsu K
J Neurosci Res. 2008
PubMed ID: 18338804
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Oxidative inactivation of the proteasome in retinal pigment epithelial cells. A potential link between oxidative stress and up-regulation of interleukin-8.
Fernandes AF, Zhou J, Zhang X, Bian Q, Sparrow J, Taylor A, Pereira P, Shang F
J Biol Chem. 2008
PubMed ID: 18502748
Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.
Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T
J Immunol. 2008
PubMed ID: 18606643
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule.
Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC, Lehmann M, Meijler MM, Janda KD, Ulevitch RJ
Science. 2008
PubMed ID: 18566250
Myostatin directly regulates skeletal muscle fibrosis.
Li ZB, Kollias HD, Wagner KR
J Biol Chem. 2008
PubMed ID: 18453534
Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.
Yoda A, Toyoshima K, Watanabe Y, Onishi N, Hazaka Y, Tsukuda Y, Tsukada J, Kondo T, Tanaka Y, Minami Y
J Biol Chem. 2008
PubMed ID: 18482988
Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase.
Matsushima-Nishiwaki R, Takai S, Adachi S, Minamitani C, Yasuda E, Noda T, Kato K, Toyoda H, Kaneoka Y, Yamaguchi A, Kumada T, Kozawa O
J Biol Chem. 2008
PubMed ID: 18477563
Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells.
Vitale I, Senovilla L, Galluzzi L, Criollo A, Vivet S, Castedo M, Kroemer G
Cell Cycle. 2008
PubMed ID: 18642443
IL-8 and p53 are inversely regulated through JNK, p38 and NF-kappaB p65 in HepG2 cells during an inflammatory response.
Rasmussen MK, Iversen L, Johansen C, Finnemann J, Olsen LS, Kragballe K, Gesser B
Inflamm Res. 2008
PubMed ID: 18607537
LPS-induced vascular endothelial growth factor expression in rat lung pericytes.
Kim CO, Huh AJ, Kim MS, Chin BS, Han SH, Choi SH, Jeong SJ, Choi HK, Choi JY, Song YG, Kim JM
Shock. 2008
PubMed ID: 18562929
Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I.
Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, Romero-Yuste S, Romero-Jung P, Gomez-Tato A, Regueiro BJ
J Gen Virol. 2008
PubMed ID: 18559936
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H
J Clin Invest. 2008
PubMed ID: 18551195
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.
Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P
Nat Immunol. 2008
PubMed ID: 18536720
Interferon-beta protects astrocytes against tumour necrosis factor-induced apoptosis via activation of p38 mitogen-activated protein kinase.
Barca O, Costoya JA, Señarís RM, Arce VM
Exp Cell Res. 2008
PubMed ID: 18501892
LPS induces melanogenesis through p38 MAPK activation in human melanocytes.
Ahn JH, Jin SH, Kang HY
Arch Dermatol Res. 2008
PubMed ID: 18478240
Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.
Du Y, Li X, Yang D, Zhang X, Chen S, Huang K, Le W
Exp Biol Med (Maywood). 2008
PubMed ID: 18445767
Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase.
Evans IM, Britton G, Zachary IC
Cell Signal. 2008
PubMed ID: 18440775
Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells.
Aggeli IK, Beis I, Gaitanaki C
Cell Signal. 2008
PubMed ID: 18420382
Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway.
Abidi P, Zhang H, Zaidi SM, Shen WJ, Leers-Sucheta S, Cortez Y, Han J, Azhar S
J Endocrinol. 2008
PubMed ID: 18417530
Asbestos-induced MKP-3 expression augments TNF-alpha gene expression in human monocytes.
Tephly LA, Carter AB
Am J Respir Cell Mol Biol. 2008
PubMed ID: 18314537
p38/NF-kB-dependent expression of COX-2 during differentiation and inflammatory response of chondrocytes.
Ulivi V, Giannoni P, Gentili C, Cancedda R, Descalzi F
J Cell Biochem. 2008
PubMed ID: 18286508
Acidic pH stimulates the production of the angiogenic CXC chemokine, CXCL8 (interleukin-8), in human adult mesenchymal stem cells via the extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and NF-kappaB pathways.
Bischoff DS, Zhu JH, Makhijani NS, Yamaguchi DT
J Cell Biochem. 2008
PubMed ID: 18275043
Signal-dependent regulation of gene expression as a target for cancer treatment: inhibiting p38alpha in colorectal tumors.
Chiacchiera F, Simone C
Cancer Lett. 2008
PubMed ID: 18395970
Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy.
Chattopadhyay M, Mata M, Fink DJ
J Neurosci. 2008
PubMed ID: 18579738
Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinase.
Sours KM, Kwok SC, Rachidi T, Lee T, Ring A, Hoofnagle AN, Resing KA, Ahn NG
J Mol Biol. 2008
PubMed ID: 18501927
Mek and p38 MAPK-dependant pathways are involoved in the positive effect of interleukin-6 on human growth hormone gene expression in rat MtT/S somatotroph cells.
Gong FY, Deng JY, Shi YF
Chin Med Sci J. 2008
PubMed ID: 18686625
Inhibition of ERK and activation of p38 are involved in diallyl disulfide induced apoptosis of leukemia HL-60 cells.
Tan H, Ling H, He J, Yi L, Zhou J, Lin M, Su Q
Arch Pharm Res. 2008
PubMed ID: 18563362
p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.
Cai B, Xia Z
Apoptosis. 2008
PubMed ID: 18465250
Angiotensin II and tumor necrosis factor-alpha synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-kappaB, p38, and reactive oxygen species.
Takahashi M, Suzuki E, Takeda R, Oba S, Nishimatsu H, Kimura K, Nagano T, Nagai R, Hirata Y
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18441197
Substance P enhances NF-kappaB transactivation and chemokine response in murine macrophages via ERK1/2 and p38 MAPK signaling pathways.
Sun J, Ramnath RD, Zhi L, Tamizhselvi R, Bhatia M
Am J Physiol Cell Physiol. 2008
PubMed ID: 18434625
Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1.
Hsu JT, Kan WH, Hsieh CH, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18434445
Quercetin induced tissue-type plasminogen activator expression is mediated through Sp1 and p38 mitogen-activated protein kinase in human endothelial cells.
Pan W, Chang MJ, Booyse FM, Grenett HE, Bradley KM, Wolkowicz PE, Shang Q, Tabengwa EM
J Thromb Haemost. 2008
PubMed ID: 18419748
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.
Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A
Mol Cell Biol. 2008
PubMed ID: 18411303
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
Kan WH, Hsu JT, Ba ZF, Schwacha MG, Chen J, Choudhry MA, Bland KI, Chaudry IH
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18408136
Leishmania initially activates but subsequently down-regulates intracellular mitogen-activated protein kinases and nuclear factor-kappaB signaling in macrophages.
Ben-Othman R, Guizani-Tabbane L, Dellagi K
Mol Immunol. 2008
PubMed ID: 18406464
SEB-induced signaling in macrophages leads to biphasic TNF-alpha.
Khan AA, Martin S, Saha B
J Leukoc Biol. 2008
PubMed ID: 18364436
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways.
Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE
Hum Mol Genet. 2008
PubMed ID: 18276609
Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H(2)O(2)-induced premature senescence and interplay with p38alpha(MAPK).
Chrétien A, Piront N, Delaive E, Demazy C, Ninane N, Toussaint O
FEBS Lett. 2008
PubMed ID: 18439424
Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality.
Almog T, Lazar S, Reiss N, Etkovitz N, Milch E, Rahamim N, Dobkin-Bekman M, Rotem R, Kalina M, Ramon J, Raziel A, Brietbart H, Seger R, Naor Z
J Biol Chem. 2008
PubMed ID: 18372245
Transforming growth factor beta1 induces alphavbeta3 integrin expression in human lung fibroblasts via a beta3 integrin-, c-Src-, and p38 MAPK-dependent pathway.
Pechkovsky DV, Scaffidi AK, Hackett TL, Ballard J, Shaheen F, Thompson PJ, Thannickal VJ, Knight DA
J Biol Chem. 2008
PubMed ID: 18353785
AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation.
Cheung WD, Hart GW
J Biol Chem. 2008
PubMed ID: 18353774
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.
Thornton TM, Pedraza-Alva G, Deng B, Wood CD, Aronshtam A, Clements JL, Sabio G, Davis RJ, Matthews DE, Doble B, Rincon M
Science. 2008
PubMed ID: 18451303
The role of RIP2 in p38 MAPK activation in the stressed heart.
Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark JE, Kobayashi KS, Flavell RA, Eickhoff J, Cotten M, Marber MS
J Biol Chem. 2008
PubMed ID: 18310079
[The role of p38 mitogen activated protein kinase in the inflammatory response of human monocytes infected with nontypeable Haemophilus influenzae].
Xu ZH, Xu F, Shen HH, Li LJ
Zhonghua Jie He He Hu Xi Za Zhi. 2008
PubMed ID: 18953958
Vibrio vulnificus-induced death of Jurkat T-cells requires activation of p38 mitogen-activated protein kinase by NADPH oxidase-derived reactive oxygen species.
Kim WH, Goo SY, Shin MH, Chun SJ, Lee H, Lee KH, Park SJ
Cell Immunol. 2008
PubMed ID: 18571150
HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase.
Leghmari K, Bennasser Y, Tkaczuk J, Bahraoui E
Cell Immunol. 2008
PubMed ID: 18541226
[Contribution of primary sensory neurons and spinal glial cells to pathomechanisms of neuropathic pain]
Obata K, Noguchi K
Brain Nerve. 2008
PubMed ID: 18516970
IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38.
Kalliolias GD, Ivashkiv LB
J Immunol. 2008
PubMed ID: 18424756
Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway.
Lemarie A, Bourdonnay E, Morzadec C, Fardel O, Vernhet L
J Immunol. 2008
PubMed ID: 18424721
Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway.
Jia G, Cheng G, Gangahar DM, Agrawal DK
J Mol Cell Cardiol. 2008
PubMed ID: 18405916
Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK.
Diradourian C, Le May C, Caüzac M, Girard J, Burnol AF, Pégorier JP
Biochim Biophys Acta. 2008
PubMed ID: 18374665
Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed.
Moon KC, Park JS, Norwitz ER, Kim DI, Oh KJ, Park CW, Jun JK, Syn HC
Placenta. 2008
PubMed ID: 18358530
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4.
Yang TT, Yu RY, Agadir A, Gao GJ, Campos-Gonzalez R, Tournier C, Chow CW
Mol Cell Biol. 2008
PubMed ID: 18347059
Role of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis.
Chrétien A, Dierick JF, Delaive E, Larsen MR, Dieu M, Raes M, Deroanne CF, Roepstorff P, Toussaint O
Free Radic Biol Med. 2008
PubMed ID: 18325348
Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase.
Yoo BK, Choi JW, Shin CY, Jeon SJ, Park SJ, Cheong JH, Han SY, Ryu JR, Song MR, Ko KH
Neurochem Int. 2008
PubMed ID: 18289732
hNUDC promotes the cell proliferation and differentiation in a leukemic cell line via activation of the thrombopoietin receptor (Mpl).
Tang YS, Zhang YP, Xu P
Leukemia. 2008
PubMed ID: 18288130
Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division.
Poggi A, Catellani S, Bruzzone A, Caligaris-Cappio F, Gobbi M, Zocchi MR
Leukemia. 2008
PubMed ID: 18288129
Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling.
Dávila D, Torres-Aleman I
Mol Biol Cell. 2008
PubMed ID: 18287535
The activation of ERK1/2 and p38 mitogen-activated protein kinases is dynamically regulated in the developing rat visual system.
Oliveira CS, Rigon AP, Leal RB, Rossi FM
Int J Dev Neurosci. 2008
PubMed ID: 18280691
Epidermal growth factor abrogates hypoxia-induced apoptosis in cultured human trophoblasts through phosphorylation of BAD Serine 112.
Humphrey RG, Sonnenberg-Hirche C, Smith SD, Hu C, Barton A, Sadovsky Y, Nelson DM
Endocrinology. 2008
PubMed ID: 18276761
Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells.
Grund EM, Kagan D, Tran CA, Zeitvogel A, Starzinski-Powitz A, Nataraja S, Palmer SS
Mol Pharmacol. 2008
PubMed ID: 18252806
Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes.
Gazel A, Nijhawan RI, Walsh R, Blumenberg M
J Cell Physiol. 2008
PubMed ID: 18247374
Mitogen-activated protein kinase up-regulation and activation during rat parotid gland atrophy and regeneration: role of epidermal growth factor and beta2-adrenergic receptors.
Dang H, Elliott JJ, Lin AL, Zhu B, Katz MS, Yeh CK
Differentiation. 2008
PubMed ID: 18177419
Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases.
Giordano G, Klintworth HM, Kavanagh TJ, Costa LG
Neurochem Int. 2008
PubMed ID: 18164102
Role of p38 in regulation of hematopoiesis: effect of p38 inhibition on cytokine production and transcription factor activity in human bone marrow stromal cells.
Scicchitano MS, McFarland DC, Tierney LA, Boyce RW, Frazier KS, Schwartz LW, Thomas HC
Blood Cells Mol Dis. 2008
PubMed ID: 18093851
Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK.
Kuang D, Zhao X, Xiao G, Ni J, Feng Y, Wu R, Wang G
Basic Res Cardiol. 2008
PubMed ID: 18087667
Ultrasound stimulates MMP-13 expression through p38 and JNK pathway in osteoblasts.
Chiu YC, Huang TH, Fu WM, Yang RS, Tang CH
J Cell Physiol. 2008
PubMed ID: 17941091
The mechanism of anti-platelet activity of davallialactone: involvement of intracellular calcium ions, extracellular signal-regulated kinase 2 and p38 mitogen-activated protein kinase.
Kim SD, Lee IK, Lee WM, Cho JY, Park HJ, Oh JW, Park SC, Kim SK, Kwak YS, Yun BS, Rhee MH
Eur J Pharmacol. 2008
PubMed ID: 18313047
A comparison of the involvement of p38, ERK1/2 and PI3K in growth factor-induced chondrogenic differentiation of mesenchymal stem cells.
McMahon LA, Prendergast PJ, Campbell VA
Biochem Biophys Res Commun. 2008
PubMed ID: 18267113
p38MAPK inhibition attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway.
Liu S, Feng G, Wang GL, Liu GJ
Eur J Pharmacol. 2008
PubMed ID: 18328478
Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease.
Lee YM, Park SH, Shin DI, Hwang JY, Park B, Park YJ, Lee TH, Chae HZ, Jin BK, Oh TH, Oh YJ
J Biol Chem. 2008
PubMed ID: 18250162
MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.
Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, Burg MB
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18367666
Change in histone H3 phosphorylation, MAP kinase p38, SIR 2 and p53 expression by resveratrol in preventing streptozotocin induced type I diabetic nephropathy.
Tikoo K, Singh K, Kabra D, Sharma V, Gaikwad A
Free Radic Res. 2008
PubMed ID: 18404539
Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway.
Bai B, Tang J, Liu H, Chen J, Li Y, Song W
Acta Biochim Biophys Sin (Shanghai). 2008
PubMed ID: 18401529
Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.
Kang YJ, Chen J, Otsuka M, Mols J, Ren S, Wang Y, Han J
J Immunol. 2008
PubMed ID: 18354233
Selective roles of MAPKs during the macrophage response to IFN-gamma.
Valledor AF, Sánchez-Tilló E, Arpa L, Park JM, Caelles C, Lloberas J, Celada A
J Immunol. 2008
PubMed ID: 18354174
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation.
Wang H, Xu Q, Xiao F, Jiang Y, Wu Z
Mol Biol Cell. 2008
PubMed ID: 18256287
Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanisms.
Wang S, Zhang J, Zhang Y, Kern S, Danner RL
J Leukoc Biol. 2008
PubMed ID: 18218858
Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways.
Heidbreder M, Naumann A, Tempel K, Dominiak P, Dendorfer A
Cardiovasc Res. 2008
PubMed ID: 18096574
UVB-induced activation of NF-kappaB is regulated by the IGF-1R and dependent on p38 MAPK.
Lewis DA, Spandau DF
J Invest Dermatol. 2008
PubMed ID: 18059487
Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC).
Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR
J Cell Physiol. 2008
PubMed ID: 17960568
p38 mitogen-activated protein kinase inhibition decreases TNFalpha secretion and protects against left ventricular remodeling in rats with myocardial ischemia.
Yin H, Zhang J, Lin H, Wang R, Qiao Y, Wang B, Liu F
Inflammation. 2008
PubMed ID: 17943427
Bone morphogenetic protein 6 inhibit stress-induced breast cancer cells apoptosis via both Smad and p38 pathways.
Du J, Yang S, Wang Z, Zhai C, Yuan W, Lei R, Zhang J, Zhu T
J Cell Biochem. 2008
PubMed ID: 17879955
Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-beta-mediated cortical synaptic dysfunction.
Origlia N, Righi M, Capsoni S, Cattaneo A, Fang F, Stern DM, Chen JX, Schmidt AM, Arancio O, Yan SD, Domenici L
J Neurosci. 2008
PubMed ID: 18367618
Smad and p38 MAP kinase-mediated signaling of proteoglycan synthesis in vascular smooth muscle.
Dadlani H, Ballinger ML, Osman N, Getachew R, Little PJ
J Biol Chem. 2008
PubMed ID: 18223258
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.
Noguchi T, Ishii K, Fukutomi H, Naguro I, Matsuzawa A, Takeda K, Ichijo H
J Biol Chem. 2008
PubMed ID: 18211888
IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages.
Zwaferink H, Stockinger S, Hazemi P, Lemmens-Gruber R, Decker T
J Immunol. 2008
PubMed ID: 18322222
Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics.
Jarnicki AG, Conroy H, Brereton C, Donnelly G, Toomey D, Walsh K, Sweeney C, Leavy O, Fletcher J, Lavelle EC, Dunne P, Mills KH
J Immunol. 2008
PubMed ID: 18322186
c-Jun N-terminal kinase and p38 mitogen-activated protein kinase mediate double-strand RNA-induced inducible nitric oxide synthase expression in microglial cells.
Kong PJ, Lee HJ, Lee SH, Kim SY, Lee SN, Chun WJ, Kim SS
Neurosci Lett. 2008
PubMed ID: 18258363
Anandamide regulates keratinocyte differentiation by inducing DNA methylation in a CB1 receptor-dependent manner.
Paradisi A, Pasquariello N, Barcaroli D, Maccarrone M
J Biol Chem. 2008
PubMed ID: 18165231
p38: the link between the kappa-opioid receptor and dysphoria.
Carr GV, Mague SD
J Neurosci. 2008
PubMed ID: 18322076
Interleukin-32 induces the differentiation of monocytes into macrophage-like cells.
Netea MG, Lewis EC, Azam T, Joosten LA, Jaekal J, Bae SY, Dinarello CA, Kim SH
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18296636
MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells.
Roduit R, Schorderet DF
Apoptosis. 2008
PubMed ID: 18253836
Involvement of the p38 MAPK-NF-kappaB signal transduction pathway and COX-2 in the pathobiology of meniscus degeneration in humans.
Papachristou DJ, Papadakou E, Basdra EK, Baltopoulos P, Panagiotopoulos E, Papavassiliou AG
Mol Med. 2008
PubMed ID: 18224252
Maternal allergy influences p38-mitogen-activated protein kinase activity upon microbial challenge in CD14+ monocytes from 2-year-old children.
Saghafian-Hedengren S, Holmlund U, Amoudruz P, Nilsson C, Sverremark-Ekström E
Clin Exp Allergy. 2008
PubMed ID: 18177491
p38 mitogen-activated protein kinase mediates lipopolysaccharide and tumor necrosis factor alpha induction of shiga toxin 2 sensitivity in human umbilical vein endothelial cells.
Stone MK, Kolling GL, Lindner MH, Obrig TG
Infect Immun. 2008
PubMed ID: 18086809
Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos.
Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H
Mech Dev. 2008
PubMed ID: 18083014
Involvement of p38 MAPK-mediated signaling in the calpeptin-mediated suppression of myogenic differentiation and fusion in C2C12 cells.
Kook SH, Choi KC, Son YO, Lee KY, Hwang IH, Lee HJ, Chung WT, Lee CB, Park JS, Lee JC
Mol Cell Biochem. 2008
PubMed ID: 18057999
ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.
Yang CS, Shin DM, Lee HM, Son JW, Lee SJ, Akira S, Gougerot-Pocidalo MA, El-Benna J, Ichijo H, Jo EK
Cell Microbiol. 2008
PubMed ID: 18028450
Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP).
Billings PC, Fiori JL, Bentwood JL, O'Connell MP, Jiao X, Nussbaum B, Caron RJ, Shore EM, Kaplan FS
J Bone Miner Res. 2008
PubMed ID: 17967130
Basic fibroblast growth factor inhibits p38-mediated cell differentiation and growth inhibition by activin A but not by histone deacetylase inhibitors in CML cells.
Chen CH, Lin JY, Liu FH, Chang JL, Huang HM
Ann Hematol. 2008
PubMed ID: 17929017
Induction of p38MAPK and HSP27 phosphorylation in pemphigus patient skin.
Berkowitz P, Diaz LA, Hall RP, Rubenstein DS
J Invest Dermatol. 2008
PubMed ID: 17928890
Participation of p38 MAPK and a novel-type protein kinase C in the control of mitochondrial Ca2+ uptake.
Szanda G, Koncz P, Rajki A, Spät A
Cell Calcium. 2008
PubMed ID: 17628663
Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1.
Blagoveshchenskaya A, Cheong FY, Rohde HM, Glover G, Knödler A, Nicolson T, Boehmelt G, Mayinger P
J Cell Biol. 2008
PubMed ID: 18299350
BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38.
Ulsamer A, Ortuño MJ, Ruiz S, Susperregui AR, Osses N, Rosa JL, Ventura F
J Biol Chem. 2008
PubMed ID: 18056716
Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB.
Sodhi A, Tripathi A
Cytokine. 2008
PubMed ID: 18248819
Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis.
Liu Y, Martinez L, Ebine K, Abe MK
Dev Biol. 2008
PubMed ID: 18177852
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
Important role of p38 MAP kinase/NF-kappaB signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype.
Yang M, Wu J, Martin CM, Kvietys PR, Rui T
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18083899
GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway.
Subramaniam S, Strelau J, Unsicker K
Cell Tissue Res. 2008
PubMed ID: 18071753
IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.
Yang HT, Cohen P, Rousseau S
Cell Signal. 2008
PubMed ID: 18065201
Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.
Kono M, Tatsumi K, Imai AM, Saito K, Kuriyama T, Shirasawa H
Antiviral Res. 2008
PubMed ID: 18055026
Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways.
Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX
Exp Mol Pathol. 2008
PubMed ID: 18054783
Ultraviolet A induced modulation of gap junctional intercellular communication by P38 MAPK activation in human keratinocytes.
Bellei B, Mastrofrancesco A, Briganti S, Aspite N, Ale-Agha N, Sies H, Picardo M
Exp Dermatol. 2008
PubMed ID: 18047584
Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils.
Saffar AS, Dragon S, Ezzati P, Shan L, Gounni AS
J Allergy Clin Immunol. 2008
PubMed ID: 18036649
Role of p38-mitogen-activated protein kinase in ischaemic preconditioning in rat heart.
Bell JR, Eaton P, Shattock MJ
Clin Exp Pharmacol Physiol. 2008
PubMed ID: 17892505
PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells.
Yuan J, Rozengurt E
J Cell Biochem. 2008
PubMed ID: 17570131
An optimized immunohistochemical method for detection of phosphorylated mitogen-activated protein kinases.
Teraishi T, Miura K, Imaki J
J Immunol Methods. 2008
PubMed ID: 18061203
Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy.
Taniike M, Yamaguchi O, Tsujimoto I, Hikoso S, Takeda T, Nakai A, Omiya S, Mizote I, Nakano Y, Higuchi Y, Matsumura Y, Nishida K, Ichijo H, Hori M, Otsu K
Circulation. 2008
PubMed ID: 18195174
Blockade of p38 MAPK inhibits chronic allograft vasculopathy.
Ollinger R, Thomas M, Kogler P, Hermann M, Weiss H, Mark W, Bilban M, Troppmair J, Bach FH, Margreiter R
Transplantation. 2008
PubMed ID: 18212636
p38alpha stabilizes interleukin-6 mRNA via multiple AU-rich elements.
Zhao W, Liu M, Kirkwood KL
J Biol Chem. 2008
PubMed ID: 18042545
Effect of the distal C162S mutation on the energetics of drug binding to p38alpha MAP kinase.
Todorova NA, Doseeva V, Ramprakash J, Schwarz FP
Arch Biochem Biophys. 2008
PubMed ID: 17996717
c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.
Galan-Moya EM, Hernandez-Losa J, Aceves Luquero CI, de la Cruz-Morcillo MA, Ramírez-Castillejo C, Callejas-Valera JL, Arriaga A, Aranburo AF, Ramón y Cajal S, Silvio Gutkind J, Sánchez-Prieto R
Int J Cancer. 2008
PubMed ID: 17893873
IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway.
Temporin K, Tanaka H, Kuroda Y, Okada K, Yachi K, Moritomo H, Murase T, Yoshikawa H
Biochem Biophys Res Commun. 2008
PubMed ID: 17996195
Cathepsins B, K, and L are regulated by a defined collagen type II peptide via activation of classical protein kinase C and p38 MAP kinase in articular chondrocytes.
Ruettger A, Schueler S, Mollenhauer JA, Wiederanders B
J Biol Chem. 2008
PubMed ID: 17991740
MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.
Yamashita T, Kobayashi Y, Mizoguchi T, Yamaki M, Miura T, Tanaka S, Udagawa N, Takahashi N
Biochem Biophys Res Commun. 2008
PubMed ID: 17983595
Extracellular calcium-sensing receptor activation induces vitamin D receptor levels in proximal kidney HK-2G cells by a mechanism that requires phosphorylation of p38alpha MAPK.
Maiti A, Hait NC, Beckman MJ
J Biol Chem. 2008
PubMed ID: 17974568
Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells.
Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, Sun K, Xiong H, Jiang G, Zhang B, Wu M, Wei L
BMC Cancer. 2008
PubMed ID: 19091131
HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.
Cardone RA, Busco G, Greco MR, Bellizzi A, Accardi R, Cafarelli A, Monterisi S, Carratù P, Casavola V, Paradiso A, Tommasino M, Reshkin SJ
PLoS ONE. 2008
PubMed ID: 18953413
P38 MAP kinase signaling is required for the conversion of CD4+CD25- T cells into iTreg.
Huber S, Schrader J, Fritz G, Presser K, Schmitt S, Waisman A, Lüth S, Blessing M, Herkel J, Schramm C
PLoS ONE. 2008
PubMed ID: 18827879
Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways.
Jung WK, Choi I, Lee DY, Yea SS, Choi YH, Kim MM, Park SG, Seo SK, Lee SW, Lee CM, Park YM, Choi IW
Int J Biochem Cell Biol. 2008
PubMed ID: 18571461
The estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples.
Olsen L, Hansen T, Jakobsen KD, Djurovic S, Melle I, Agartz I, Hall H, Ullum H, Timm S, Wang AG, Jönsson EG, Andreassen OA, Werge T
BMC Med Genet. 2008
PubMed ID: 18460190
Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK.
Yoshida S, Nagase M, Shibata S, Fujita T
Nephron Exp Nephrol. 2008
PubMed ID: 18391505
Dynamics in the p38alpha MAP kinase-SB203580 complex observed by liquid-state NMR spectroscopy.
Honndorf VS, Coudevylle N, Laufer S, Becker S, Griesinger C
Angew Chem Int Ed Engl. 2008
PubMed ID: 18389508
Human herpesvirus 6B induces phosphorylation of p53 in its regulatory domain by a CK2- and p38-independent pathway.
Oster B, Bundgaard B, Hupp TR, Höllsberg P
J Gen Virol. 2008
PubMed ID: 18089732
CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK.
Huang J, Shi T, Ma T, Zhang Y, Ma X, Lu Y, Song Q, Liu W, Ma D, Qiu X
Cell Mol Life Sci. 2008
PubMed ID: 18087676
Altered myocardial gene expression reveals possible maladaptive processes in heterozygous and homozygous cardiac myosin-binding protein C knockout mice.
Eijssen LM, van den Bosch BJ, Vignier N, Lindsey PJ, van den Burg CM, Carrier L, Doevendans PA, van der Vusse GJ, Smeets HJ
Genomics. 2008
PubMed ID: 18060737
A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents.
Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou GP, Dolkas J, Myers RR, Gonias SL, Campana WM
J Clin Invest. 2008
PubMed ID: 18060043
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.
Zeidan A, Javadov S, Chakrabarti S, Karmazyn M
Cardiovasc Res. 2008
PubMed ID: 18006472
Activation of p38 mitogen-activated protein kinase abolishes insulin-mediated myocardial protection against ischemia-reperfusion injury.
Chai W, Wu Y, Li G, Cao W, Yang Z, Liu Z
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18003719
Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase.
Izumi Y, Tokuda K, Zorumski CF
Hippocampus. 2008
PubMed ID: 18000819
Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.
Ballard-Croft C, Locklar AC, Keith BJ, Mentzer RM, Lasley RD
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 17965278
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking.
Wälchli S, Skånland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K
Mol Biol Cell. 2008
PubMed ID: 17959827
Increased activation of p38 MAPK in COPD.
Renda T, Baraldo S, Pelaia G, Bazzan E, Turato G, Papi A, Maestrelli P, Maselli R, Vatrella A, Fabbri LM, Zuin R, Marsico SA, Saetta M
Eur Respir J. 2008
PubMed ID: 17959643
A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia.
Cui Y, Liao XX, Liu W, Guo RX, Wu ZZ, Zhao CM, Chen PX, Feng JQ
Brain Behav Immun. 2008
PubMed ID: 17919885
Attenuation of p38 MAPK activity upon contact inhibition in fibroblasts.
Slisz M, Rothenberger E, Hutter D
Mol Cell Biochem. 2008
PubMed ID: 17906919
Insulin-induced myocardial protection in isolated ischemic rat hearts requires p38 MAPK phosphorylation of Hsp27.
Li G, Ali IS, Currie RW
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 17906111
Strong induction of the Tis11B gene in myogenic differentiation.
Busse M, Schwarzburger M, Berger F, Hacker C, Munz B
Eur J Cell Biol. 2008
PubMed ID: 17889962
Antagonistic control of cell fates by JNK and p38-MAPK signaling.
Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM
Cell Death Differ. 2008
PubMed ID: 17762881
Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways.
Deleault KM, Skinner SJ, Brooks SA
Mol Immunol. 2008
PubMed ID: 17606294
TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.
Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C
Mol Immunol. 2008
PubMed ID: 17599408
Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success.
Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK
J Biol Chem. 2007
PubMed ID: 17965409
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
p38 MAPK inhibition in nucleus pulposus cells: a potential target for treating intervertebral disc degeneration.
Studer RK, Aboka AM, Gilbertson LG, Georgescu H, Sowa G, Vo N, Kang JD
Spine. 2007
PubMed ID: 18246004
The relationship between p38MAPK and apoptosis during paclitaxel resistance of ovarian cancer cells.
Lu M, Xiao L, Li Z
J Huazhong Univ Sci Technolog Med Sci. 2007
PubMed ID: 18231754
Effects of p38 mitogen-activated protein kinase inhibition on blood pressure, renal hemodynamics, and renal vascular reactivity in normal and diabetic rats.
Komers R, Schutzer W, Xue H, Oyama TT, Lindsley JN, Anderson S
Transl Res. 2007
PubMed ID: 18022596
Hyperosmotic stress-induced caspase-3 activation is mediated by p38 MAPK in the hippocampus.
Niswander JM, Dokas LA
Brain Res. 2007
PubMed ID: 17996851
p38alpha MAP kinase-deficient mouse embryonic stem cells can differentiate to endothelial cells, smooth muscle cells, and neurons.
Guo YL, Ye J, Huang F
Dev Dyn. 2007
PubMed ID: 17994546
IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.
Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17921324
Kinase activities increase during the development of tauopathy in htau mice.
Kelleher I, Garwood C, Hanger DP, Anderton BH, Noble W
J Neurochem. 2007
PubMed ID: 17908241
p38 and ERK1/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis.
Dhingra S, Sharma AK, Singla DK, Singal PK
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17906102
The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia.
Jacquet S, Zarrinpashneh E, Chavey A, Ginion A, Leclerc I, Viollet B, Rutter GA, Bertrand L, Marber MS
Cardiovasc Res. 2007
PubMed ID: 17765884
The activity of caspase-1 is increased in lesional psoriatic epidermis.
Johansen C, Moeller K, Kragballe K, Iversen L
J Invest Dermatol. 2007
PubMed ID: 17597823
Cell type-specific activation of p38 MAPK in the brain regions of hypoxic preconditioned mice.
Bu X, Huang P, Qi Z, Zhang N, Han S, Fang L, Li J
Neurochem Int. 2007
PubMed ID: 17583386
Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPAR delta expression.
Imai H, Numaguchi Y, Ishii M, Kubota R, Yokouchi K, Ogawa Y, Kondo T, Okumura K, Murohara T
Atherosclerosis. 2007
PubMed ID: 17303142
Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.
O'Keefe SJ, Mudgett JS, Cupo S, Parsons JN, Chartrain NA, Fitzgerald C, Chen SL, Lowitz K, Rasa C, Visco D, Luell S, Carballo-Jane E, Owens K, Zaller DM
J Biol Chem. 2007
PubMed ID: 17855341
p38 MAPK regulates COPII recruitment.
Wang L, Lucocq JM
Biochem Biophys Res Commun. 2007
PubMed ID: 17888403
MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65.
Saha RN, Jana M, Pahan K
J Immunol. 2007
PubMed ID: 17982102
Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts.
Tokuda H, Hanai Y, Matsushima-Nishiwaki R, Yamauchi J, Doi T, Harada A, Takai S, Kozawa O
Biochem Biophys Res Commun. 2007
PubMed ID: 17825250
Modulation of the p38MAPK pathway in failing human myocardium secondary to rheumatic heart disease.
Su Q, Chen J, Fang Q
J Heart Valve Dis. 2007
PubMed ID: 18095520
Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice.
Noubade R, Milligan G, Zachary JF, Blankenhorn EP, del Rio R, Rincon M, Teuscher C
J Clin Invest. 2007
PubMed ID: 17965772
Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
Cao L, Yu K, Banh C, Nguyen V, Ritz A, Raphael BJ, Kawakami Y, Kawakami T, Salomon AR
J Immunol. 2007
PubMed ID: 17947660
Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.
Wang X, Nadarajah B, Robinson AC, McColl BW, Jin JW, Dajas-Bailador F, Boot-Handford RP, Tournier C
Mol Cell Biol. 2007
PubMed ID: 17875933
Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A.
Korporaal SJ, Van Eck M, Adelmeijer J, Ijsseldijk M, Out R, Lisman T, Lenting PJ, Van Berkel TJ, Akkerman JW
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17761940
Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells.
Caverzasio J, Manen D
Endocrinology. 2007
PubMed ID: 17717053
ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation.
Thellung S, Villa V, Corsaro A, Pellistri F, Venezia V, Russo C, Aceto A, Robello M, Florio T
Glia. 2007
PubMed ID: 17705195
Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.
Liu SI, Huang CC, Huang CJ, Wang BW, Chang PM, Fang YC, Chen WC, Wang JL, Lu YC, Chu ST, Chou CT, Jan CR
Toxicol Sci. 2007
PubMed ID: 17698513
MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney.
Ma FY, Tesch GH, Flavell RA, Davis RJ, Nikolic-Paterson DJ
Am J Physiol Renal Physiol. 2007
PubMed ID: 17686961
CXCR1/2 ligands induce p38 MAPK-dependent translocation and release of opioid peptides from primary granules in vitro and in vivo.
Rittner HL, Labuz D, Richter JF, Brack A, Schäfer M, Stein C, Mousa SA
Brain Behav Immun. 2007
PubMed ID: 17604950
Different roles of spinal p38 and c-Jun N-terminal kinase pathways in bee venom-induced multiple pain-related behaviors.
Cao FL, Liu MG, Hao J, Li Z, Lu ZM, Chen J
Neurosci Lett. 2007
PubMed ID: 17923327
Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation.
Serra C, Palacios D, Mozzetta C, Forcales SV, Morantte I, Ripani M, Jones DR, Du K, Jhala US, Simone C, Puri PL
Mol Cell. 2007
PubMed ID: 17964260
Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects.
Corona G, Deiana M, Incani A, Vauzour D, Dessì MA, Spencer JP
Biochem Biophys Res Commun. 2007
PubMed ID: 17727817
p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.
Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G
J Biol Chem. 2007
PubMed ID: 17724032
Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria.
Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, Chavkin C
J Neurosci. 2007
PubMed ID: 17959804
Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-alpha signaling.
Zer C, Sachs G, Shin JM
Physiol Genomics. 2007
PubMed ID: 17652167
MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
Abell AN, Granger DA, Johnson GL
J Biol Chem. 2007
PubMed ID: 17726008
Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK.
Chang J, Sonoyama W, Wang Z, Jin Q, Zhang C, Krebsbach PH, Giannobile W, Shi S, Wang CY
J Biol Chem. 2007
PubMed ID: 17720811
Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle.
Ho RC, Fujii N, Witters LA, Hirshman MF, Goodyear LJ
Biochem Biophys Res Commun. 2007
PubMed ID: 17709097
Intracellular JNK, p38 MAPK and NF-kappaB regulate IL-25 induced release of cytokines and chemokines from costimulated T helper lymphocytes.
Wong CK, Li PW, Lam CW
Immunol Lett. 2007
PubMed ID: 17719653
Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells.
Kim JS, Ryoo ZY, Chun JS
J Biol Chem. 2007
PubMed ID: 17644814
[A study on the time-dependent expression of phospho-p38MAPK during the skin incised wound healing in mice]
Zhang JJ, Guan DW, Yang DL
Fa Yi Xue Za Zhi. 2007
PubMed ID: 18175565
Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways.
Ben-Eliezer M, Phillip M, Gat-Yablonski G
Endocrine. 2007
PubMed ID: 18080100
Carbon monoxide protects rat lung transplants from ischemia-reperfusion injury via a mechanism involving p38 MAPK pathway.
Kohmoto J, Nakao A, Stolz DB, Kaizu T, Tsung A, Ikeda A, Shimizu H, Takahashi T, Tomiyama K, Sugimoto R, Choi AM, Billiar TR, Murase N, McCurry KR
Am J Transplant. 2007
PubMed ID: 17711551
The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway.
Barco R, Hunt LB, Frump AL, Garcia CB, Benesh A, Caldwell RL, Eid JE
Mol Biol Cell. 2007
PubMed ID: 17686994
Involvement of p38 MAP kinase in lipopolysaccharide-induced production of pro- and anti-inflammatory cytokines and prostaglandin E(2) in human choriodecidua.
Shoji T, Yoshida S, Mitsunari M, Miyake N, Tsukihara S, Iwabe T, Harada T, Terakawa N
J Reprod Immunol. 2007
PubMed ID: 17617469
Involvement of endogenous nitric oxide in angiotensin II-induced activation of vascular mitogen-activated protein kinases.
Zhang GX, Nagai Y, Nakagawa T, Miyanaka H, Fujisawa Y, Nishiyama A, Izuishi K, Ohmori K, Kimura S
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17616751
p38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death.
El Mchichi B, Hadji A, Vazquez A, Leca G
Cell Death Differ. 2007
PubMed ID: 17585337
Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway.
Ma L, Wang HY
J Biol Chem. 2007
PubMed ID: 17684012
Hypercytokinemia and hyperactivation of phospho-p38 mitogen-activated protein kinase in severe human influenza A virus infection.
Lee N, Wong CK, Chan PK, Lun SW, Lui G, Wong B, Hui DS, Lam CW, Cockram CS, Choi KW, Yeung AC, Tang JW, Sung JJ
Clin Infect Dis. 2007
PubMed ID: 17712756
Involvement of p38MAPK on the antinociceptive action of myricitrin in mice.
Meotti FC, Posser T, Missau FC, Pizzolatti MG, Leal RB, Santos AR
Biochem Pharmacol. 2007
PubMed ID: 17678631
Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
Patel DN, King CA, Bailey SR, Holt JW, Venkatachalam K, Agrawal A, Valente AJ, Chandrasekar B
J Biol Chem. 2007
PubMed ID: 17652082
[Changes of p38 MAPK and nuclear factor-kappa B in lung tissue of acute paraquat poisoned rats].
Tong F, Tian YP, Huo SH, Hu L, Su JL, Chen H, Wang X, Liu LD, Gao HB, Shi HW
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007
PubMed ID: 17997883
By blocking apoptosis, Bcl-2 in p38-dependent manner promotes cell cycle arrest and accelerated senescence after DNA damage and serum withdrawal.
Nelyudova A, Aksenov N, Pospelov V, Pospelova T
Cell Cycle. 2007
PubMed ID: 17882791
Angiotensin II and IGF-1 regulate connexin43 expression via ERK and p38 signaling pathways in vascular smooth muscle cells of coronary artery bypass conduits.
Jia G, Mitra AK, Cheng G, Gangahar DM, Agrawal DK
J Surg Res. 2007
PubMed ID: 17624368
Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.
Sheng G, Guo J, Warner BW
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17615176
p38MAPK-activated AKT in HER-2 overexpressing human breast cancer cells acts as an EGF-independent survival signal.
Diehl KM, Grewal N, Ethier SP, Woods-Ignatoski KM
J Surg Res. 2007
PubMed ID: 17612563
Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation.
Lim MJ, Seo YH, Choi KJ, Cho CH, Kim BS, Kim YH, Lee J, Lee H, Jung CY, Ha J, Kang I, Kim SS
Arch Biochem Biophys. 2007
PubMed ID: 17612500
TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K signaling pathways.
Martin MM, Buckenberger JA, Jiang J, Malana GE, Knoell DL, Feldman DS, Elton TS
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17601799
Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation.
Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, Fu XY, Meldrum DR
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17595217
Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis.
Honmo S, Ozaki A, Yamamoto M, Hashimoto N, Miyakoshi M, Tanaka H, Yoshie M, Tamakawa S, Tokusashi Y, Yaginuma Y, Kasai S, Ogawa K
Mol Carcinog. 2007
PubMed ID: 17546627
Role of p38 mitogen-activated protein kinase on cardiac dysfunction after hemorrhagic shock in rats.
Sato H, Tanaka T, Kasai K, Kita T, Tanaka N
Shock. 2007
PubMed ID: 17545949
Glutamine supplementation prevents exercise-induced neutrophil apoptosis and reduces p38 MAPK and JNK phosphorylation and p53 and caspase 3 expression.
Lagranha CJ, Hirabara SM, Curi R, Pithon-Curi TC
Cell Biochem Funct. 2007
PubMed ID: 17542038
H2O2 activation of HSP25/27 protects desmin from calpain proteolysis in rat ventricular myocytes.
Blunt BC, Creek AT, Henderson DC, Hofmann PA
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17513494
Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression.
Xu Z, Tavares-Sanchez OL, Li Q, Fernando J, Rodriguez CM, Studer EJ, Pandak WM, Hylemon PB, Gil G
J Biol Chem. 2007
PubMed ID: 17603092
G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes.
Seo M, Lee MJ, Heo JH, Lee YI, Kim Y, Kim SY, Lee ES, Juhnn YS
J Biol Chem. 2007
PubMed ID: 17548351
Inhibition of p38 mitogen-activated protein kinase attenuates experimental autoimmune hepatitis: involvement of nuclear factor kappa B.
Ma X, Jia YT, Qiu DK
World J Gastroenterol. 2007
PubMed ID: 17696256
A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells.
Takahashi N, Nagamine M, Tanno S, Motomura W, Kohgo Y, Okumura T
Biochem Biophys Res Commun. 2007
PubMed ID: 17588539
Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release.
Zhong J, Kyriakis JM
J Biol Chem. 2007
PubMed ID: 17584736
Rosiglitazone attenuates NF-kappaB-dependent ICAM-1 and TNF-alpha production caused by homocysteine via inhibiting ERK1/2/p38MAPK activation.
Bai YP, Liu YH, Chen J, Song T, You Y, Tang ZY, Li YJ, Zhang GG
Biochem Biophys Res Commun. 2007
PubMed ID: 17583675
Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.
Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N
Genes Dev. 2007
PubMed ID: 17699753
Platelet factor 4 (CXC chemokine ligand 4) differentially regulates respiratory burst, survival, and cytokine expression of human monocytes by using distinct signaling pathways.
Kasper B, Brandt E, Brandau S, Petersen F
J Immunol. 2007
PubMed ID: 17675521
p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells.
Junttila MR, Ala-Aho R, Jokilehto T, Peltonen J, Kallajoki M, Grenman R, Jaakkola P, Westermarck J, Kähäri VM
Oncogene. 2007
PubMed ID: 17334397
p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum.
Zuluaga S, Gutiérrez-Uzquiza A, Bragado P, Alvarez-Barrientos A, Benito M, Nebreda AR, Porras A
FEBS Lett. 2007
PubMed ID: 17658519
A functional role for p38 MAPK in modulating mitotic transit in the absence of stress.
Cha H, Wang X, Li H, Fornace AJ
J Biol Chem. 2007
PubMed ID: 17548358
Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6.
Fu P, Thompson JA, Bach LA
J Biol Chem. 2007
PubMed ID: 17519236
Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway.
Estrella VC, Eder AM, Liu S, Pustilnik TB, Tabassam FH, Claret FX, Gallick GE, Mills GB, Wiener JR
Int J Oncol. 2007
PubMed ID: 17611702
Stretch-induced MAP kinase activation in cardiac myocytes: differential regulation through beta1-integrin and focal adhesion kinase.
Lal H, Verma SK, Smith M, Guleria RS, Lu G, Foster DM, Dostal DE
J Mol Cell Cardiol. 2007
PubMed ID: 17583725
Inhibition of p38 MAPK and AMPK restores adenosine-induced cardioprotection in hearts stressed by antecedent ischemia by altering glucose utilization.
Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17496214
p38 MAP-kinases pathway regulation, function and role in human diseases.
Cuenda A, Rousseau S
Biochim Biophys Acta. 2007
PubMed ID: 17481747
Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation.
Amantini C, Mosca M, Nabissi M, Lucciarini R, Caprodossi S, Arcella A, Giangaspero F, Santoni G
J Neurochem. 2007
PubMed ID: 17442041
Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.
Li JP, Yang JL
J Cell Physiol. 2007
PubMed ID: 17373649
17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells.
Caiazza F, Galluzzo P, Lorenzetti S, Marino M
Biochem Biophys Res Commun. 2007
PubMed ID: 17524358
EGFR activation results in enhanced cyclooxygenase-2 expression through p38 mitogen-activated protein kinase-dependent activation of the Sp1/Sp3 transcription factors in human gliomas.
Xu K, Shu HK
Cancer Res. 2007
PubMed ID: 17616668
Heart HIF-1alpha and MAP kinases during hypoxia: are they associated in vivo?
Caretti A, Morel S, Milano G, Fantacci M, Bianciardi P, Ronchi R, Vassalli G, von Segesser LK, Samaja M
Exp Biol Med (Maywood). 2007
PubMed ID: 17609504
Mechanisms of kringle fragment of urokinase-induced vascular smooth muscle cell migration.
Roztocil E, Nicholl SM, Davies MG
J Surg Res. 2007
PubMed ID: 17574041
Schistosoma mansoni infection enhances host portal vein contraction: role of potassium channels and p38 MAP kinase.
Araujo FP, Quintas LE, Noël F, Silva CL
Microbes Infect. 2007
PubMed ID: 17544802
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha.
Hao F, Tan M, Xu X, Han J, Miller DD, Tigyi G, Cui MZ
Biochim Biophys Acta. 2007
PubMed ID: 17531530
MAPK activation in the hippocampus in vivo is correlated with experimental setting.
Belelovsky K, Maroun M, Rosenblum K
Neurobiol Learn Mem. 2007
PubMed ID: 17467311
Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580.
Hamanoue M, Sato K, Takamatsu K
Neurochem Int. 2007
PubMed ID: 17459526
Insulin-like growth factor-I induces cyclooxygenase-2 expression via PI3K, MAPK and PKC signaling pathways in human ovarian cancer cells.
Cao Z, Liu LZ, Dixon DA, Zheng JZ, Chandran B, Jiang BH
Cell Signal. 2007
PubMed ID: 17341442
Roles of Na+/H+ exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts.
Rentsch ML, Ossum CG, Hoffmann EK, Pedersen SF
Pflugers Arch. 2007
PubMed ID: 17334779
Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver.
Iida C, Fujii K, Kishioka T, Nagae R, Onishi Y, Ichi I, Kojo S
Arch Toxicol. 2007
PubMed ID: 17285312
Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases.
Ruusalepp A, Czibik G, Flatebø T, Vaage J, Valen G
Basic Res Cardiol. 2007
PubMed ID: 17268885
PP2Cdelta (Ppm1d, WIP1), an endogenous inhibitor of p38 MAPK, is regulated along with Trp53 and Cdkn2a following p38 MAPK inhibition during mouse preimplantation development.
Hickson JA, Fong B, Watson PH, Watson AJ
Mol Reprod Dev. 2007
PubMed ID: 17219434
Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1alpha and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation.
Wright DC, Geiger PC, Han DH, Jones TE, Holloszy JO
J Biol Chem. 2007
PubMed ID: 17488713
Retinoic acids acting through retinoid receptors protect hippocampal neurons from oxygen-glucose deprivation-mediated cell death by inhibition of c-jun-N-terminal kinase and p38 mitogen-activated protein kinase.
Shinozaki Y, Sato Y, Koizumi S, Ohno Y, Nagao T, Inoue K
Neuroscience. 2007
PubMed ID: 17521827
Genetic ablation of Rac1 in cartilage results in chondrodysplasia.
Wang G, Woods A, Agoston H, Ulici V, Glogauer M, Beier F
Dev Biol. 2007
PubMed ID: 17467682
Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses.
Bohnenkamp HR, Papazisis KT, Burchell JM, Taylor-Papadimitriou J
Cell Immunol. 2007
PubMed ID: 17927969
Gp120-mediated cytotoxicity of human brain microvascular endothelial cells is dependent on p38 mitogen-activated protein kinase activation.
Khan NA, Di Cello F, Stins M, Kim KS
J Neurovirol. 2007
PubMed ID: 17613714
Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection.
Perdiguero E, Ruiz-Bonilla V, Serrano AL, Muñoz-Cánoves P
Cell Cycle. 2007
PubMed ID: 17534150
Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway.
Wu H, Wang X, Liu S, Wu Y, Zhao T, Chen X, Zhu L, Wu Y, Ding X, Peng X, Yuan J, Wang X, Fan W, Fan M
Eur J Cell Biol. 2007
PubMed ID: 17498836
p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway.
Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, Komnenovic V, Scheuch H, Beug H, Wagner EF
Nat Genet. 2007
PubMed ID: 17468757
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, Nebreda AR
Nat Genet. 2007
PubMed ID: 17468755
Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3.
Prickett TD, Brautigan DL
Mol Cell Biol. 2007
PubMed ID: 17438131
Hypoxia-induced apoptosis and tube breakdown are regulated by p38 MAPK but not by caspase cascade in an in vitro capillary model composed of human endothelial cells.
Ohta T, Eguchi R, Suzuki A, Miyakaze S, Ayuzawa R, Kaji K
J Cell Physiol. 2007
PubMed ID: 17373651
Exposure of C6 glioma cells to Pb(II) increases the phosphorylation of p38(MAPK) and JNK1/2 but not of ERK1/2.
Posser T, de Aguiar CB, Garcez RC, Rossi FM, Oliveira CS, Trentin AG, Neto VM, Leal RB
Arch Toxicol. 2007
PubMed ID: 17333127
Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth.
Rocic P, Kolz C, Reed R, Potter B, Chilian WM
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17308014
The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase.
Sugawara Y, Nishii H, Takahashi T, Yamauchi J, Mizuno N, Tago K, Itoh H
Cell Signal. 2007
PubMed ID: 17307333
Involvement of MAPKs and NF-kappaB in LPS-induced VCAM-1 expression in human tracheal smooth muscle cells.
Lin WN, Luo SF, Lee CW, Wang CC, Wang JS, Yang CM
Cell Signal. 2007
PubMed ID: 17303384
Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2.
Eguchi R, Suzuki A, Miyakaze S, Kaji K, Ohta T
Cell Signal. 2007
PubMed ID: 17303382
Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage.
Hsu JT, Hsieh YC, Kan WH, Chen JG, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17293487
The lipid peroxidation end-product 4-HNE induces COX-2 expression through p38MAPK activation in 3T3-L1 adipose cell.
Zarrouki B, Soares AF, Guichardant M, Lagarde M, Géloën A
FEBS Lett. 2007
PubMed ID: 17481611
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.
Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada T, Brownlee M, Nishikawa T, Araki E
Circ Res. 2007
PubMed ID: 17463321
Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.
Bukhtiyarova M, Karpusas M, Northrop K, Namboodiri HV, Springman EB
Biochemistry. 2007
PubMed ID: 17441692
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase.
Bhattacharyya S, Brown DE, Brewer JA, Vogt SK, Muglia LJ
Blood. 2007
PubMed ID: 17255352
Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells.
Adler HS, Kubsch S, Graulich E, Ludwig S, Knop J, Steinbrink K
Blood. 2007
PubMed ID: 17244678
Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.
Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE
J Clin Invest. 2007
PubMed ID: 17446930
Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death.
Dewil M, dela Cruz VF, Van Den Bosch L, Robberecht W
Neurobiol Dis. 2007
PubMed ID: 17346981
The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.
Cardone RA, Bellizzi A, Busco G, Weinman EJ, Dell'Aquila ME, Casavola V, Azzariti A, Mangia A, Paradiso A, Reshkin SJ
Mol Biol Cell. 2007
PubMed ID: 17332506
Heat shock protein 1 and the mitogen-activated protein kinase 14 pathway are important for mouse trophoblast stem cell differentiation.
Winger QA, Guttormsen J, Gavin H, Bhushan F
Biol Reprod. 2007
PubMed ID: 17267699
Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation.
Fülöp N, Zhang Z, Marchase RB, Chatham JC
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17208994
Mycobacterium bovis-mediated induction of human beta-defensin-2 in epithelial cells is controlled by intracellular calcium and p38MAPK.
Méndez-Samperio P, Alba L, Trejo A
J Infect. 2007
PubMed ID: 17000004
Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression.
Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C
Exp Mol Med. 2007
PubMed ID: 17464186
p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells.
Ko J, Yun CY, Lee JS, Kim JH, Kim IS
Exp Mol Med. 2007
PubMed ID: 17464174
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
Cuadrado A, Lafarga V, Cheung PC, Dolado I, Llanos S, Cohen P, Nebreda AR
EMBO J. 2007
PubMed ID: 17380123
Characterization of apoptotic pathway associated with caspase-independent excision of DNA loop domains.
Solovyan VT
Exp Cell Res. 2007
PubMed ID: 17362930
A critical role for p38 map kinase in NF-kappaB signaling during intermittent hypoxia/reoxygenation.
Ryan S, McNicholas WT, Taylor CT
Biochem Biophys Res Commun. 2007
PubMed ID: 17316568
Molecular basis of MAPK-activated protein kinase 2:p38 assembly.
White A, Pargellis CA, Studts JM, Werneburg BG, Farmer BT
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17395714
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389395
MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival.
Demuth T, Reavie LB, Rennert JL, Nakada M, Nakada S, Hoelzinger DB, Beaudry CE, Henrichs AN, Anderson EM, Berens ME
Mol Cancer Ther. 2007
PubMed ID: 17406030
p38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor-kappaB degradation in human coronary artery endothelial cells.
Chai W, Liu Z
Endocrinology. 2007
PubMed ID: 17234706
Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy.
Kocanova S, Buytaert E, Matroule JY, Piette J, Golab J, de Witte P, Agostinis P
Apoptosis. 2007
PubMed ID: 17219054
p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix.
Wang X, Goh CH, Li B
Endocrinology. 2007
PubMed ID: 17185377
p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.
Jaswal JS, Gandhi M, Finegan BA, Dyck JR, Clanachan AS
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17172269
Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.
ter Haar E, Prabhakar P, Prabakhar P, Liu X, Lepre C
J Biol Chem. 2007
PubMed ID: 17255097
The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.
Meissner JD, Chang KC, Kubis HP, Nebreda AR, Gros G, Scheibe RJ
J Biol Chem. 2007
PubMed ID: 17210568
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.
Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C
J Neurosci. 2007
PubMed ID: 17344394
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.
Perdiguero E, Ruiz-Bonilla V, Gresh L, Hui L, Ballestar E, Sousa-Victor P, Baeza-Raja B, Jardí M, Bosch-Comas A, Esteller M, Caelles C, Serrano AL, Wagner EF, Muñoz-Cánoves P
EMBO J. 2007
PubMed ID: 17304211
Conditional activation of MET in differentiated skeletal muscle induces atrophy.
Crepaldi T, Bersani F, Scuoppo C, Accornero P, Prunotto C, Taulli R, Forni PE, Leo C, Chiarle R, Griffiths J, Glass DJ, Ponzetto C
J Biol Chem. 2007
PubMed ID: 17194700
Nitric oxide inhibits interleukin-12 p40 through p38 MAPK-mediated regulation of calmodulin and c-rel.
Boddupalli CS, Ghosh S, Rahim SS, Nair S, Ehtesham NZ, Hasnain SE, Mukhopadhyay S
Free Radic Biol Med. 2007
PubMed ID: 17291992
Expression of the p38 MAPK, NF-kappaB and cyclin D1 in extramammary Paget's disease.
Lin N, Uchi H, Moroi Y, Fukiwake N, Dainichi T, Takeuchi S, Takahara M, Tu Y, Furue M, Urabe K
J Dermatol Sci. 2007
PubMed ID: 17207971
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the releas
Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, Romeo G, Federico M, Geyer M, Affabris E
J Virol. 2007
PubMed ID: 17182689
17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage.
Hsieh YC, Frink M, Thobe BM, Hsu JT, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
Mol Immunol. 2007
PubMed ID: 17182102
Contraction-induced interleukin-6 transcription in rat slow-type muscle is partly dependent on calcineurin activation.
Banzet S, Koulmann N, Sanchez H, Serrurier B, Peinnequin A, Alonso A, Bigard X
J Cell Physiol. 2007
PubMed ID: 17133350
Differential regulation of TNFalpha and GM-CSF induced activation of P38 MAPK in neutrophils and eosinophils.
ten Hove W, Houben LA, Raaijmakers JA, Bracke M, Koenderman L
Mol Immunol. 2007
PubMed ID: 17126905
The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage.
Thobe BM, Frink M, Hildebrand F, Schwacha MG, Hubbard WJ, Choudhry MA, Chaudry IH
J Cell Physiol. 2007
PubMed ID: 17117477
Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK.
Watanabe K, Ma M, Hirabayashi K, Gurusamy N, Veeraveedu PT, Prakash P, Zhang S, Muslin AJ, Kodama M, Aizawa Y
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17040971
Effects of peripheral inflammation on activation of p38 mitogen-activated protein kinase in the rostral ventromedial medulla.
Imbe H, Okamoto K, Aikawa F, Kimura A, Donishi T, Tamai Y, Iwai-Liao Y, Senba E
Brain Res. 2007
PubMed ID: 17196178
Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation.
Ivanova IA, Dagnino L
Oncogene. 2007
PubMed ID: 16924238
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.
Yu W, Imoto I, Inoue J, Onda M, Emi M, Inazawa J
Oncogene. 2007
PubMed ID: 16924234
p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity.
Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ
Circ Res. 2007
PubMed ID: 17234967
p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.
Shida Y, Igawa T, Hakariya T, Sakai H, Kanetake H
Biochem Biophys Res Commun. 2007
PubMed ID: 17196171
Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes.
Mishra S, Mishra JP, Kumar A
J Biol Chem. 2007
PubMed ID: 17158886
Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition.
Frossi B, Rivera J, Hirsch E, Pucillo C
J Immunol. 2007
PubMed ID: 17277164
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.
Maneechotesuwan K, Xin Y, Ito K, Jazrawi E, Lee KY, Usmani OS, Barnes PJ, Adcock IM
J Immunol. 2007
PubMed ID: 17277157
Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons.
Ster J, De Bock F, Guérineau NC, Janossy A, Barrère-Lemaire S, Bos JL, Bockaert J, Fagni L
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17284589
Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2.
Kinoshita M, Eguchi Y, Hynynen K
Biochem Biophys Res Commun. 2007
PubMed ID: 17188240
Mxi2 promotes stimulus-independent ERK nuclear translocation.
Casar B, Sanz-Moreno V, Yazicioglu MN, Rodríguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P
EMBO J. 2007
PubMed ID: 17255949
Effects of statin treatment and withdrawal on angiotensin II-induced phosphorylation of p38 MAPK and ERK1/2 in cultured vascular smooth muscle cells.
Tristano AG, Castejon AM, Castro A, Cubeddu LX
Biochem Biophys Res Commun. 2007
PubMed ID: 17161379
Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis.
Kondoh K, Sunadome K, Nishida E
J Biol Chem. 2007
PubMed ID: 17158101
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis.
Dolado I, Swat A, Ajenjo N, De Vita G, Cuadrado A, Nebreda AR
Cancer Cell. 2007
PubMed ID: 17292829
Intrinsically active variants of all human p38 isoforms.
Avitzour M, Diskin R, Raboy B, Askari N, Engelberg D, Livnah O
FEBS J. 2007
PubMed ID: 17241234
p38 MAP kinase regulation of oligodendrocyte differentiation with CREB as a potential target.
Bhat NR, Zhang P, Mohanty SB
Neurochem Res. 2007
PubMed ID: 17235686
Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
Nat Immunol. 2007
PubMed ID: 17187070
Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction.
Bogatcheva NV, Adyshev D, Mambetsariev B, Moldobaeva N, Verin AD
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17012370
Feedback control of MKP-1 expression by p38.
Hu JH, Chen T, Zhuang ZH, Kong L, Yu MC, Liu Y, Zang JW, Ge BX
Cell Signal. 2007
PubMed ID: 16978838
HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection.
Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA
Cell Death Differ. 2007
PubMed ID: 16841089
p38 MAP kinase drives the expression of mast cell-derived IL-9 via activation of the transcription factor GATA-1.
Stassen M, Klein M, Becker M, Bopp T, Neudörfl C, Richter C, Heib V, Klein-Hessling S, Serfling E, Schild H, Schmitt E
Mol Immunol. 2007
PubMed ID: 16650898
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen.
Liu YC, Ko CC, Cheng FC, Huang PT, Lou KL, Chow LP
Biochem Biophys Res Commun. 2007
PubMed ID: 17141198
Guanosine inhibits CD40 receptor expression and function induced by cytokines and beta amyloid in mouse microglia cells.
D'Alimonte I, Flati V, D'Auro M, Toniato E, Martinotti S, Rathbone MP, Jiang S, Ballerini P, Di Iorio P, Caciagli F, Ciccarelli R
J Immunol. 2007
PubMed ID: 17202332
Augmented lipopolysaccharide-induced TNF-alpha production by peritoneal macrophages in type 2 diabetic mice is dependent on elevated glucose and requires p38 MAPK.
Sherry CL, O'Connor JC, Kramer JM, Freund GG
J Immunol. 2007
PubMed ID: 17202326
Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.
Clarke CJ, Truong TG, Hannun YA
J Biol Chem. 2007
PubMed ID: 17085432
Epidermal growth factor up-regulates transforming growth factor-beta receptor type II in human dermal fibroblasts via p38 mitogen-activated protein kinase pathway.
Yamane K, Asano Y, Tamaki K, Ihn H
Biochem Biophys Res Commun. 2007
PubMed ID: 17107667
Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription.
Askari N, Diskin R, Avitzour M, Capone R, Livnah O, Engelberg D
J Biol Chem. 2007
PubMed ID: 17088247
Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation.
Diskin R, Lebendiker M, Engelberg D, Livnah O
J Mol Biol. 2007
PubMed ID: 17059827
Enhanced soluble production of biologically active recombinant human p38 mitogen-activated-protein kinase (MAPK) in Escherichia coli.
Khattar SK, Gulati P, Kundu PK, Singh V, Bughani U, Bajpai M, Saini KS
Protein Pept Lett. 2007
PubMed ID: 17979814
The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun.
Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, Pannen BH
Int J Biochem Cell Biol. 2007
PubMed ID: 17689131
Transcriptional activation of MMP-13 by periodontal pathogenic LPS requires p38 MAP kinase.
Rossa C, Liu M, Bronson P, Kirkwood KL
J Endotoxin Res. 2007
PubMed ID: 17621549
Involvement of p38alpha in kainate-induced seizure and neuronal cell damage.
Namiki K, Nakamura A, Furuya M, Mizuhashi S, Matsuo Y, Tokuhara N, Sudo T, Hama H, Kuwaki T, Yano S, Kimura S, Kasuya Y
J Recept Signal Transduct Res. 2007
PubMed ID: 17613723
ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5'-triphosphate-mediated terminal erythroid differentiation of K562 cells.
Moosavi MA, Yazdanparast R, Lotfi A
Int J Biochem Cell Biol. 2007
PubMed ID: 17543571
Beta-endorphin regulation of MAPKs in cultured human articular chondrocytes: MAPK inhibitors prevent the increase of IL-1 beta protein levels during beta-endorphin stimulation.
Andjelkov N, Elvenes J, Knutsen G, Johansen O
Cell Commun Adhes. 2007
PubMed ID: 17453826
The TGFbeta1-induced fibronectin in human renal proximal tubular epithelial cells is p38 MAP kinase dependent and Smad independent.
Niculescu-Duvaz I, Phanish MK, Colville-Nash P, Dockrell ME
Nephron Exp Nephrol. 2007
PubMed ID: 17347580
Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis.
Yu X, Bauer K, Koczan D, Thiesen HJ, Ibrahim SM
Arthritis Res Ther. 2007
PubMed ID: 17244351
[Correlation of p38 mitogen-activated protein kinase signal transduction pathway to uPA expression in breast cancer]
Han YC, Zeng XX, Wang R, Zhao Y, Li BL, Song M
Ai Zheng. 2007
PubMed ID: 17222367
Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation.
Fong B, Watson PH, Watson AJ
BMC Dev Biol. 2007
PubMed ID: 17214902
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.
Singh S, Yin X, Pisano MM, Greene RM
Birth Defects Res A Clin Mol Teratol. 2007
PubMed ID: 17177285
Generation of survival signal by differential interaction of p38MAPKalpha and p38MAPKbeta with caveolin-1 and caveolin-3 in the adapted heart.
Das M, Cui J, Das DK
J Mol Cell Cardiol. 2007
PubMed ID: 17069850
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB
Mol Cell Biol. 2007
PubMed ID: 17030606
n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism.
Rao JS, Ertley RN, Lee HJ, DeMar JC, Arnold JT, Rapoport SI, Bazinet RP
Mol Psychiatry. 2007
PubMed ID: 16983391
All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells.
Hormi-Carver K, Feagins LA, Spechler SJ, Souza RF
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 16935849
The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival.
Wang Y, Zeigler MM, Lam GK, Hunter MG, Eubank TD, Khramtsov VV, Tridandapani S, Sen CK, Marsh CB
Am J Respir Cell Mol Biol. 2007
PubMed ID: 16931806
p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity.
Siddiqui SS, Siddiqui ZK, Uddin S, Minshall RD, Malik AB
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 16891390
Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1.
Zuluaga S, Alvarez-Barrientos A, Gutiérrez-Uzquiza A, Benito M, Nebreda AR, Porras A
Cell Signal. 2007
PubMed ID: 16844343
BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway.
Jin EJ, Lee SY, Choi YA, Jung JC, Bang OS, Kang SS
Mol Cells. 2006
PubMed ID: 17202865
Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
Seimon TA, Obstfeld A, Moore KJ, Golenbock DT, Tabas I
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17167049
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ, Anderson CW, Appella E, Bulavin DV
J Exp Med. 2006
PubMed ID: 17158963
Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization.
Tew SR, Hardingham TE
J Biol Chem. 2006
PubMed ID: 17050539
The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate.
Ziv I, Fuchs Y, Preger E, Shabtay A, Harduf H, Zilpa T, Dym N, Ron D
J Biol Chem. 2006
PubMed ID: 17035228
Inhibition of MAPK stimulates the Ca2+ -dependent big-conductance K channels in cortical collecting duct.
Li D, Wang Z, Sun P, Jin Y, Lin DH, Hebert SC, Giebisch G, Wang WH
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17151195
Beta-glucan is a fungal determinant for adhesion-dependent human neutrophil functions.
Lavigne LM, Albina JE, Reichner JS
J Immunol. 2006
PubMed ID: 17142767
p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.
Frey MR, Dise RS, Edelblum KL, Polk DB
EMBO J. 2006
PubMed ID: 17139251
Induction of c-Fos and NFATc1 during RANKL-stimulated osteoclast differentiation is mediated by the p38 signaling pathway.
Huang H, Chang EJ, Ryu J, Lee ZH, Lee Y, Kim HH
Biochem Biophys Res Commun. 2006
PubMed ID: 17052691
Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation.
Lovett FA, Gonzalez I, Salih DA, Cobb LJ, Tripathi G, Cosgrove RA, Murrell A, Kilshaw PJ, Pell JM
J Cell Sci. 2006
PubMed ID: 17105766
Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB.
Saha B, Singh SK, Sarkar C, Bera R, Ratha J, Tobin DJ, Bhadra R
Pigment Cell Res. 2006
PubMed ID: 17083486
Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1.
Cui H, Cai F, Belsham DD
FASEB J. 2006
PubMed ID: 17077290
Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK.
Zhou Y, Wang Q, Mark Evers B, Chung DH
Biochem Biophys Res Commun. 2006
PubMed ID: 17034759
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
Kitatani K, Idkowiak-Baldys J, Bielawski J, Taha TA, Jenkins RW, Senkal CE, Ogretmen B, Obeid LM, Hannun YA
J Biol Chem. 2006
PubMed ID: 17030510
Involvement of p38alpha mitogen-activated protein kinase in lung metastasis of tumor cells.
Matsuo Y, Amano S, Furuya M, Namiki K, Sakurai K, Nishiyama M, Sudo T, Tatsumi K, Kuriyama T, Kimura S, Kasuya Y
J Biol Chem. 2006
PubMed ID: 17028194
MAPK-activated protein kinase-2 (MK2)-mediated formation and phosphorylation-regulated dissociation of the signal complex consisting of p38, MK2, Akt, and Hsp27.
Zheng C, Lin Z, Zhao ZJ, Yang Y, Niu H, Shen X
J Biol Chem. 2006
PubMed ID: 17015449
Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27.
Venkatakrishnan CD, Tewari AK, Moldovan L, Cardounel AJ, Zweier JL, Kuppusamy P, Ilangovan G
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16782845
Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
Khurana A, Nakayama K, Williams S, Davis RJ, Mustelin T, Ronai Z
J Biol Chem. 2006
PubMed ID: 17003045
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.
Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17090686
Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo.
Takaesu G, Kang JS, Bae GU, Yi MJ, Lee CM, Reddy EP, Krauss RS
J Cell Biol. 2006
PubMed ID: 17074887
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
KIOM-79 inhibits LPS-induced iNOS gene expression by blocking NF-kappaB/Rel and p38 kinase activation in murine macrophages.
Jeon YJ, Li MH, Lee KY, Kim JS, You HJ, Lee SK, Sohn HM, Choi SJ, Koh JW, Chang IY
J Ethnopharmacol. 2006
PubMed ID: 16806764
Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy.
Li J, Campanale NV, Liang RJ, Deane JA, Bertram JF, Ricardo SD
Am J Pathol. 2006
PubMed ID: 17071578
Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway.
Makino C, Sano Y, Shinagawa T, Millar JB, Ishii S
Genes Cells. 2006
PubMed ID: 17054722
Involvement of p38 MAP kinase in not only activation of the phagocyte NADPH oxidase induced by formyl-methionyl-leucyl-phenylalanine but also determination of the extent of the activity.
Sakamoto K, Kuribayashi F, Nakamura M, Takeshige K
J Biochem. 2006
PubMed ID: 17030506
Cell signaling pathways to alphaB-crystallin following stresses of the cytoskeleton.
Launay N, Goudeau B, Kato K, Vicart P, Lilienbaum A
Exp Cell Res. 2006
PubMed ID: 16979163
Low-density lipoprotein modified by macrophage-derived lysosomal hydrolases induces expression and secretion of IL-8 via p38 MAPK and NF-kappaB by human monocyte-derived macrophages.
Hakala JK, Lindstedt KA, Kovanen PT, Pentikäinen MO
Arterioscler Thromb Vasc Biol. 2006
PubMed ID: 16973972
The HBP1 transcriptional repressor participates in RAS-induced premature senescence.
Zhang X, Kim J, Ruthazer R, McDevitt MA, Wazer DE, Paulson KE, Yee AS
Mol Cell Biol. 2006
PubMed ID: 16966377
Nitration of p38 MAPK in the placenta: association of nitration with reduced catalytic activity of p38 MAPK in pre-eclampsia.
Webster RP, Brockman D, Myatt L
Mol Hum Reprod. 2006
PubMed ID: 16951426
Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells.
Ho TC, Yang YC, Cheng HC, Wu AC, Chen SL, Chen HK, Tsao YP
Apoptosis. 2006
PubMed ID: 16927023
Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27.
Rafiee P, Theriot ME, Nelson VM, Heidemann J, Kanaa Y, Horowitz SA, Rogaczewski A, Johnson CP, Ali I, Shaker R, Binion DG
Am J Physiol Cell Physiol. 2006
PubMed ID: 16790501
CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway.
Rousseau S, Dolado I, Beardmore V, Shpiro N, Marquez R, Nebreda AR, Arthur JS, Case LM, Tessier-Lavigne M, Gaestel M, Cuenda A, Cohen P
Cell Signal. 2006
PubMed ID: 16574378
Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.
Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F, Murga C
Curr Biol. 2006
PubMed ID: 17055984
E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.
Hershko T, Korotayev K, Polager S, Ginsberg D
J Biol Chem. 2006
PubMed ID: 16912047
Ras signaling is essential for lens cell proliferation and lens growth during development.
Xie L, Overbeek PA, Reneker LW
Dev Biol. 2006
PubMed ID: 16889766
ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury.
Xu Z, Wang BR, Wang X, Kuang F, Duan XL, Jiao XY, Ju G
Life Sci. 2006
PubMed ID: 16978658
[Effect of HCMV on p38MAPK, apoptosis and cell cycle of human glioma U251 cells]
Chen LY, Luo M, Li TC, Dai G, Luo MH
Zhonghua Er Ke Za Zhi. 2006
PubMed ID: 17229385
Altered cell adhesion and cell viability in a p38alpha mitogen-activated protein kinase-deficient mouse embryonic stem cell line.
Guo YL, Yang B
Stem Cells Dev. 2006
PubMed ID: 17105401
Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells.
Yoshino Y, Aoyagi M, Tamaki M, Duan L, Morimoto T, Ohno K
Int J Oncol. 2006
PubMed ID: 16964394
Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus.
Westermann D, Rutschow S, Van Linthout S, Linderer A, Bücker-Gärtner C, Sobirey M, Riad A, Pauschinger M, Schultheiss HP, Tschöpe C
Diabetologia. 2006
PubMed ID: 16937126
IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression.
Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, Qin G, Goukassian D, Zhu Y, Losordo DW, Kishore R
FASEB J. 2006
PubMed ID: 16935932
p38 Mitogen-activated protein kinase affects transforming growth factor-beta/Smad signaling in human dental pulp cells.
Wang FM, Hu T, Tan H, Zhou XD
Mol Cell Biochem. 2006
PubMed ID: 16924420
Selective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury.
Li Z, Ma JY, Kerr I, Chakravarty S, Dugar S, Schreiner G, Protter AA
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16751295
Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells.
Aggeli IK, Gaitanaki C, Beis I
Cell Signal. 2006
PubMed ID: 16531007
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals.
Wu Y, Fan Y, Xue B, Luo L, Shen J, Zhang S, Jiang Y, Yin Z
Oncogene. 2006
PubMed ID: 16636664
p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.
Zwang Y, Yarden Y
EMBO J. 2006
PubMed ID: 16932740
Neutrophil signaling pathways activated by bacterial DNA stimulation.
Alvarez ME, Fuxman Bass JI, Geffner JR, Calotti PX, Costas M, Coso OA, Gamberale R, Vermeulen ME, Salamone G, Martinez D, Tanos T, Trevani AS
J Immunol. 2006
PubMed ID: 16951367
Multiple activation mechanisms of p38alpha mitogen-activated protein kinase.
Kang YJ, Seit-Nebi A, Davis RJ, Han J
J Biol Chem. 2006
PubMed ID: 16849316
p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.
Lee SK, Jang HJ, Lee HJ, Lee J, Jeon BH, Jun CD, Lee SK, Kim EC
Life Sci. 2006
PubMed ID: 16697418
Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.
Jones DR, Bultsma Y, Keune WJ, Halstead JR, Elouarrat D, Mohammed S, Heck AJ, D'Santos CS, Divecha N
Mol Cell. 2006
PubMed ID: 16949365
Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha.
Yoon MJ, Lee GY, Chung JJ, Ahn YH, Hong SH, Kim JB
Diabetes. 2006
PubMed ID: 16936205
The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner.
Pongratz G, McAlees JW, Conrad DH, Erbe RS, Haas KM, Sanders VM
J Immunol. 2006
PubMed ID: 16920928
CD23-mediated transport of IgE/immune complexes across human intestinal epithelium: role of p38 MAPK.
Tu Y, Perdue MH
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16899715
Signal transducer and activator of transcription factor 1 mediates apoptosis induced by hepatitis C virus and HIV envelope proteins in hepatocytes.
Balasubramanian A, Ganju RK, Groopman JE
J Infect Dis. 2006
PubMed ID: 16897667
Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK.
Kim JS, Saengsirisuwan V, Sloniger JA, Teachey MK, Henriksen EJ
Free Radic Biol Med. 2006
PubMed ID: 16895802
Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.
Bissonauth V, Roy S, Gravel M, Guillemette S, Charron J
Development. 2006
PubMed ID: 16887817
Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain.
Yin J, Liu YH, Xu YF, Zhang YJ, Chen JG, Shu BH, Wang JZ
J Pineal Res. 2006
PubMed ID: 16879317
p38 Kinase rescues failing myocardium after myocardial infarction: evidence for angiogenic and anti-apoptotic mechanisms.
Tenhunen O, Soini Y, Ilves M, Rysä J, Tuukkanen J, Serpi R, Pennanen H, Ruskoaho H, Leskinen H
FASEB J. 2006
PubMed ID: 16849392
p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis.
Grethe S, Coltella N, Di Renzo MF, Pörn-Ares MI
Biochem Biophys Res Commun. 2006
PubMed ID: 16843435
TGF-beta1 induces COX-2 expression and PGE2 synthesis through MAPK and PI3K pathways in human mesangial cells.
Rodríguez-Barbero A, Dorado F, Velasco S, Pandiella A, Banas B, López-Novoa JM
Kidney Int. 2006
PubMed ID: 16820791
p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65.
Cai B, Chang SH, Becker EB, Bonni A, Xia Z
J Biol Chem. 2006
PubMed ID: 16818494
Glial cell-derived neurotrophic factor (GDNF) promotes low-grade Hs683 glioma cell migration through JNK, ERK-1/2 and p38 MAPK signaling pathways.
Song H, Moon A
Neurosci Res. 2006
PubMed ID: 16814421
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.
Li J, Stouffs M, Serrander L, Banfi B, Bettiol E, Charnay Y, Steger K, Krause KH, Jaconi ME
Mol Biol Cell. 2006
PubMed ID: 16775014
Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways.
Abdulnour RE, Peng X, Finigan JH, Han EJ, Hasan EJ, Birukov KG, Reddy SP, Watkins JE, Kayyali US, Garcia JG, Tuder RM, Hassoun PM
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16632522
Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia.
Thobe BM, Frink M, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
Am J Physiol Cell Physiol. 2006
PubMed ID: 16571868
Enhancement of anti-inflammatory tendency by SB203580, p38alpha specific inhibitor, in human fibroblast-like synoviocyte cell line, MH7A.
Han SK, Jeon SJ, Miyazawa K, Yi SY, Yoo YS
Rheumatol Int. 2006
PubMed ID: 16532349
Fyn kinase acts upstream of Shp2 and p38 mitogen-activated protein kinase to promote chemotaxis of mast cells towards stem cell factor.
Samayawardhena LA, Hu J, Stein PL, Craig AW
Cell Signal. 2006
PubMed ID: 16442778
Betaglycan induces TGF-beta signaling in a ligand-independent manner, through activation of the p38 pathway.
Santander C, Brandan E
Cell Signal. 2006
PubMed ID: 16413747
c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity.
Stepniak E, Ricci R, Eferl R, Sumara G, Sumara I, Rath M, Hui L, Wagner EF
Genes Dev. 2006
PubMed ID: 16912279
p38 MAP kinase activity is correlated with angiotensin II type 1 receptor blocker-induced left ventricular reverse remodeling in spontaneously hypertensive heart failure rats.
Liang Q, Elson AC, Gerdes AM
J Card Fail. 2006
PubMed ID: 16911916
Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX.
Perchonock CE, Fernando MC, Quinn WJ, Nguyen CT, Sun J, Shapiro MJ, Shapiro VS
Mol Cell Biol. 2006
PubMed ID: 16880512
Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase.
Kuki S, Imanishi T, Kobayashi K, Matsuo Y, Obana M, Akasaka T
Circ J. 2006
PubMed ID: 16864945
CDC25B phosphorylation by p38 and MK-2.
Lemaire M, Froment C, Boutros R, Mondesert O, Nebreda AR, Monsarrat B, Ducommun B
Cell Cycle. 2006
PubMed ID: 16861915
Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells.
Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A, Hecht I, Sela U, Vlodavsky I, Nagler A
J Leukoc Biol. 2006
PubMed ID: 16769768
Transforming growth factor-beta1-induced endothelial barrier dysfunction involves Smad2-dependent p38 activation and subsequent RhoA activation.
Lu Q, Harrington EO, Jackson H, Morin N, Shannon C, Rounds S
J Appl Physiol. 2006
PubMed ID: 16645187
p38 mitogen-activated protein kinase mediates the sustained phase of hypoxic pulmonary vasoconstriction and plays a role in phase I vasodilation.
Morrell ED, Tsai BM, Wang M, Crisostomo PR, Meldrum DR
J Surg Res. 2006
PubMed ID: 16542681
Short-chain fatty acid mediated phosphorylation of heat shock protein 25: effects on camptothecin-induced apoptosis.
Parhar K, Baer KA, Parker K, Ropeleski MJ
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16469826
Lipoteichoic acid-induced nitric oxide synthase expression in RAW 264.7 macrophages is mediated by cyclooxygenase-2, prostaglandin E2, protein kinase A, p38 MAPK, and nuclear factor-kappaB pathways.
Chang YC, Li PC, Chen BC, Chang MS, Wang JL, Chiu WT, Lin CH
Cell Signal. 2006
PubMed ID: 16289764
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Dreissigacker U, Mueller MS, Unger M, Siegert P, Genze F, Gierschik P, Giehl K
Cell Signal. 2006
PubMed ID: 16257181
Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences.
De Chiara G, Marcocci ME, Torcia M, Lucibello M, Rosini P, Bonini P, Higashimoto Y, Damonte G, Armirotti A, Amodei S, Palamara AT, Russo T, Garaci E, Cozzolino F
J Biol Chem. 2006
PubMed ID: 16714293
Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.
Poolos NP, Bullis JB, Roth MK
J Neurosci. 2006
PubMed ID: 16870744
Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes.
Nguyen J, Gogusev J, Knapnougel P, Bauvois B
Immunol Lett. 2006
PubMed ID: 16720051
TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats.
Zhou FH, Foster BK, Zhou XF, Cowin AJ, Xian CJ
J Bone Miner Res. 2006
PubMed ID: 16813528
ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.
Yao Y, Xu Q, Kwon MJ, Matta R, Liu Y, Hong SC, Chang CH
J Immunol. 2006
PubMed ID: 16785500
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice.
Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, Nabi AH, Nishiyama A, Sugaya T, Hayashi M, Inagami T
J Am Soc Nephrol. 2006
PubMed ID: 16738017
RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion.
Calleros L, Lasa M, Rodríguez-Alvarez FJ, Toro MJ, Chiloeches A
Apoptosis. 2006
PubMed ID: 16699960
Benzo[a]pyrene-induced cell cycle progression is through ERKs/cyclin D1 pathway and requires the activation of JNKs and p38 mapk in human diploid lung fibroblasts.
Du HJ, Tang N, Liu BC, You BR, Shen FH, Ye M, Gao A, Huang C
Mol Cell Biochem. 2006
PubMed ID: 16699726
Nitric oxide and p38 MAP kinase mediate shear stress-dependent inhibition of MMP-2 production in microvascular endothelial cells.
Milkiewicz M, Kelland C, Colgan S, Haas TL
J Cell Physiol. 2006
PubMed ID: 16575906
Testosterone attenuates p38 MAPK pathway during Leishmania donovani infection of macrophages.
Liu L, Wang L, Zhao Y, Wang Y, Wang Z, Qiao Z
Parasitol Res. 2006
PubMed ID: 16547729
Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes.
Ohno S, Im HJ, Knudson CB, Knudson W
J Biol Chem. 2006
PubMed ID: 16648633
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.
Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L
Cell. 2006
PubMed ID: 16751104
Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.
McLaughlin NJ, Banerjee A, Kelher MR, Gamboni-Robertson F, Hamiel C, Sheppard FR, Moore EE, Silliman CC
J Immunol. 2006
PubMed ID: 16709866
Activation of p38 mitogen-activated protein kinase promotes epidermal growth factor receptor internalization.
Vergarajauregui S, San Miguel A, Puertollano R
Traffic. 2006
PubMed ID: 16683917
Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages.
Chelvarajan RL, Liu Y, Popa D, Getchell ML, Getchell TV, Stromberg AJ, Bondada S
J Leukoc Biol. 2006
PubMed ID: 16603589
p38 MAPK plays a role in IL-4 synthesis in jacalin plus CD28-stimulated CD4+ T cells--II.
Tamma SM, Chung KW, Patel T, Balan SP, Pahwa S
J Leukoc Biol. 2006
PubMed ID: 16554354
Computational sampling of a cryptic drug binding site in a protein receptor: explicit solvent molecular dynamics and inhibitor docking to p38 MAP kinase.
Frembgen-Kesner T, Elcock AH
J Mol Biol. 2006
PubMed ID: 16616932
JNK (c-Jun NH2 terminal kinase) and p38 during ischemia reperfusion injury in the small intestine.
Murayama T, Tanabe M, Matsuda S, Shimazu M, Kamei S, Wakabayashi G, Kawachi S, Matsumoto K, Yamazaki K, Matsumoto K, Koyasu S, Kitajima M
Transplantation. 2006
PubMed ID: 16699462
TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes.
Ambrosino C, Iwata T, Scafoglio C, Mallardo M, Klein R, Nebreda AR
Biochem J. 2006
PubMed ID: 16492136
Determinants that control the specific interactions between TAB1 and p38alpha.
Zhou H, Zheng M, Chen J, Xie C, Kolatkar AR, Zarubin T, Ye Z, Akella R, Lin S, Goldsmith EJ, Han J
Mol Cell Biol. 2006
PubMed ID: 16648477
Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity.
Kogkopoulou O, Tzakos E, Mavrothalassitis G, Baldari CT, Paliogianni F, Young HA, Thyphronitis G
J Leukoc Biol. 2006
PubMed ID: 16478922
p38 mitogen-activated protein kinase stimulates estrogen-mediated transcription and proliferation through the phosphorylation and potentiation of the p160 coactivator glucocorticoid receptor-interacting protein 1.
Frigo DE, Basu A, Nierth-Simpson EN, Weldon CB, Dugan CM, Elliott S, Collins-Burow BM, Salvo VA, Zhu Y, Melnik LI, Lopez GN, Kushner PJ, Curiel TJ, Rowan BG, McLachlan JA, Burow ME
Mol Endocrinol. 2006
PubMed ID: 16410316
Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells.
Yeh CT, Yen GC
Carcinogenesis. 2006
PubMed ID: 16308312
Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1.
Spaziani A, Alisi A, Sanna D, Balsano C
J Biol Chem. 2006
PubMed ID: 16446363
Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses.
Berenson LS, Yang J, Sleckman BP, Murphy TL, Murphy KM
J Immunol. 2006
PubMed ID: 16585552
p38 MAPK in development and cancer.
Bradham C, McClay DR
Cell Cycle. 2006
PubMed ID: 16627995
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Angiotensin II stimulates the synthesis of vascular endothelial growth factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytes.
Kang YS, Park YG, Kim BK, Han SY, Jee YH, Han KH, Lee MH, Song HK, Cha DR, Kang SW, Han DS
J Mol Endocrinol. 2006
PubMed ID: 16595708
Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.
Hu Y, Mivechi NF
Mol Cell Biol. 2006
PubMed ID: 16581800
Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells.
Jiang DJ, Jia SJ, Dai Z, Li YJ
J Mol Cell Cardiol. 2006
PubMed ID: 16516911
Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury.
Piao ZG, Cho IH, Park CK, Hong JP, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB
Pain. 2006
PubMed ID: 16495005
Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.
Maezawa I, Nivison M, Montine KS, Maeda N, Montine TJ
FASEB J. 2006
PubMed ID: 16481366
Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway.
Wang XM, Kim HP, Song R, Choi AM
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16357362
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.
Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2006
PubMed ID: 16514068
Activation of Bak and Bax through c-abl-protein kinase Cdelta-p38 MAPK signaling in response to ionizing radiation in human non-small cell lung cancer cells.
Choi SY, Kim MJ, Kang CM, Bae S, Cho CK, Soh JW, Kim JH, Kang S, Chung HY, Lee YS, Lee SJ
J Biol Chem. 2006
PubMed ID: 16410245
Tumor evasion of the immune system: inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma.
Wang S, Yang J, Qian J, Wezeman M, Kwak LW, Yi Q
Blood. 2006
PubMed ID: 16291589
TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
Lu G, Kang YJ, Han J, Herschman HR, Stefani E, Wang Y
J Biol Chem. 2006
PubMed ID: 16407200
p38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2.
Bu SZ, Huang Q, Jiang YM, Min HB, Hou Y, Guo ZY, Wei JF, Wang JW, Ni X, Zheng SS
Apoptosis. 2006
PubMed ID: 16538384
p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells.
Farley N, Pedraza-Alva G, Serrano-Gomez D, Nagaleekar V, Aronshtam A, Krahl T, Thornton T, Rincón M
Mol Cell Biol. 2006
PubMed ID: 16507991
P38 MAP kinase mediates transforming growth factor-beta2 transcription in human keloid fibroblasts.
Xia W, Longaker MT, Yang GP
Am J Physiol Regul Integr Comp Physiol. 2006
PubMed ID: 16467496
Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity.
Guo H, Gao C, Mi Z, Wai PY, Kuo PC
Biochem J. 2006
PubMed ID: 16351573
A G protein-associated ERK pathway is involved in LPS-induced proliferation and a PTK-associated p38 MAPK pathway is involved in LPS-induced differentiation in resting B cells.
Kim J, Yang HY, Jang YS
Mol Immunol. 2006
PubMed ID: 16098594
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.
Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L
J Exp Med. 2006
PubMed ID: 16476765
Low density lipoproteins inhibit the Na+/H+ antiport in human platelets via activation of p38MAP kinase.
Nofer JR, Noll C, Feuerborn R, Assmann G, Tepel M
Biochem Biophys Res Commun. 2006
PubMed ID: 16380078
Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38.
Hao W, Takano T, Guillemette J, Papillon J, Ren G, Cybulsky AV
J Biol Chem. 2006
PubMed ID: 16316999
Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages.
Aouadi M, Laurent K, Prot M, Le Marchand-Brustel Y, Binétruy B, Bost F
Diabetes. 2006
PubMed ID: 16443758
A role for p38 mitogen-activated protein kinase and c-myc in endothelin-dependent rat aortic smooth muscle cell proliferation.
Chen S, Qiong Y, Gardner DG
Hypertension. 2006
PubMed ID: 16365184
The kinase p38 regulates peroxisome proliferator activated receptor-gamma in human trophoblasts.
Schild RL, Sonnenberg-Hirche CM, Schaiff WT, Bildirici I, Nelson DM, Sadovsky Y
Placenta. 2006
PubMed ID: 16338464
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3.
Li Z, Zhang G, Feil R, Han J, Du X
Blood. 2006
PubMed ID: 16210341
Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells.
Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, Natarajan V
Biochem J. 2006
PubMed ID: 16197369
Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats.
Matsumoto-Ida M, Takimoto Y, Aoyama T, Akao M, Takeda T, Kita T
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16183734
E2F1 stability is regulated by a novel-PKC/p38beta MAP kinase signaling pathway during keratinocyte differentiation.
Ivanova IA, D'Souza SJ, Dagnino L
Oncogene. 2006
PubMed ID: 16116476
Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production.
Xiao YQ, Freire-de-Lima CG, Janssen WJ, Morimoto K, Lyu D, Bratton DL, Henson PM
J Immunol. 2006
PubMed ID: 16394011
Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.
Zhang R, Murakami S, Coustry F, Wang Y, de Crombrugghe B
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16387856
Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure.
Dobreva I, Waeber G, James RW, Widmann C
J Biol Chem. 2006
PubMed ID: 16251188
Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: involvement of mechanical stress-activated calcium influx, PKC and Src activation.
Katz S, Boland R, Santillán G
Int J Biochem Cell Biol. 2006
PubMed ID: 16893669
Reduction in chronic allograft nephropathy by inhibition of p38 mitogen-activated protein kinase.
Wada T, Azuma H, Furuichi K, Sakai N, Kitagawa K, Iwata Y, Matsushima K, Takahara S, Yokoyama H, Kaneko S
Am J Nephrol. 2006
PubMed ID: 16816533
The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis.
Sunahori K, Yamamura M, Yamana J, Takasugi K, Kawashima M, Yamamoto H, Chazin WJ, Nakatani Y, Yui S, Makino H
Arthritis Res Ther. 2006
PubMed ID: 16613612
CD95-induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen-activated protein kinase.
Wei L, Sun XJ, Wang Z, Chen Q
Arthritis Res Ther. 2006
PubMed ID: 16469115
Activation of p38 MAPKinase/cPLA2 pathway in homocysteine-treated platelets.
Leoncini G, Bruzzese D, Signorello MG
J Thromb Haemost. 2006
PubMed ID: 16409471
Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo.
Harada C, Nakamura K, Namekata K, Okumura A, Mitamura Y, Iizuka Y, Kashiwagi K, Yoshida K, Ohno S, Matsuzawa A, Tanaka K, Ichijo H, Harada T
Am J Pathol. 2006
PubMed ID: 16400028
Nuclear protein NP60 regulates p38 MAPK activity.
Fu J, Yang Z, Wei J, Han J, Gu J
J Cell Sci. 2006
PubMed ID: 16352664
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Differential patterns of extracellular signal-regulated kinase-1 and -2 phosphorylation in rat limbic brain regions after short-term and long-term inhibitory avoidance learning.
Chai SC, Holahan MR, Shyu BC, Wang CC
Neuroscience. 2006
PubMed ID: 16326014
Cationic liposomes induce apoptosis through p38 MAP kinase-caspase-8-Bid pathway in macrophage-like RAW264.7 cells.
Iwaoka S, Nakamura T, Takano S, Tsuchiya S, Aramaki Y
J Leukoc Biol. 2006
PubMed ID: 16275897
Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-beta1-induced release of extracellular fibroblast growth factor-2 and phosphorylation of p38 MAPK and JNK.
Khalil N, Xu YD, O'Connor R, Duronio V
J Biol Chem. 2005
PubMed ID: 16246848
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.
Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R
Mol Cell. 2005
PubMed ID: 16364914
Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.
Sullivan JE, Holdgate GA, Campbell D, Timms D, Gerhardt S, Breed J, Breeze AL, Bermingham A, Pauptit RA, Norman RA, Embrey KJ, Read J, VanScyoc WS, Ward WH
Biochemistry. 2005
PubMed ID: 16342939
Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases.
Rösch S, Ramer R, Brune K, Hinz B
Biochem Biophys Res Commun. 2005
PubMed ID: 16256948
CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
Aissouni Y, Zapart G, Iovanna JL, Dikic I, Soubeyran P
Biochem Biophys Res Commun. 2005
PubMed ID: 16256071
p38 MAP kinase regulates benzo(a)pyrene-induced apoptosis through the regulation of p53 activation.
Kim SJ, Ko CB, Park C, Kim BR, Sung TH, Koh DH, Kim NS, Oh KJ, Chung SY, Park R
Arch Biochem Biophys. 2005
PubMed ID: 16297369
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding.
Zhang Q, Muller M, Chen CH, Zeng L, Farooq A, Zhou MM
J Mol Biol. 2005
PubMed ID: 16288922
Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase.
Talukdar I, Szeszel-Fedorowicz W, Salati LM
J Biol Chem. 2005
PubMed ID: 16210322
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase.
Kim H, Kokkotou E, Na X, Rhee SH, Moyer MP, Pothoulakis C, Lamont JT
Gastroenterology. 2005
PubMed ID: 16344056
Effect of p38 MAP kinase on cellular events during ischemia and reperfusion: possible therapy.
Maulik N
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 16284105
Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.
Michelotti EL, Moffett KK, Nguyen D, Kelly MJ, Shetty R, Chai X, Northrop K, Namboodiri V, Campbell B, Flynn GA, Fujimoto T, Hollinger FP, Bukhtiyarova M, Springman EB, Karpusas M
Bioorg Med Chem Lett. 2005
PubMed ID: 16169718
Inhibition of p38 reduces myocardial infarction injury in the mouse but not pig after ischemia-reperfusion.
Kaiser RA, Lyons JM, Duffy JY, Wagner CJ, McLean KM, O'Neill TP, Pearl JM, Molkentin JD
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 16143643
Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent.
Seay U, Sedding D, Krick S, Hecker M, Seeger W, Eickelberg O
J Pharmacol Exp Ther. 2005
PubMed ID: 16120811
Role of F-actin organization in p38 MAP kinase-mediated apoptosis and necrosis in neonatal rat cardiomyocytes subjected to simulated ischemia and reoxygenation.
Okada T, Otani H, Wu Y, Kyoi S, Enoki C, Fujiwara H, Sumida T, Hattori R, Imamura H
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 16040713
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN
Oncogene. 2005
PubMed ID: 16027724
Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK.
Guan J, Luo Y, Denker BM
Biochem J. 2005
PubMed ID: 15948714
Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy.
Hendrickx N, Dewaele M, Buytaert E, Marsboom G, Janssens S, Van Boven M, Vandenheede JR, de Witte P, Agostinis P
Biochem Biophys Res Commun. 2005
PubMed ID: 16214108
p38alpha MAPK is required for contact inhibition.
Faust D, Dolado I, Cuadrado A, Oesch F, Weiss C, Nebreda AR, Dietrich C
Oncogene. 2005
PubMed ID: 16027723
Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation.
Shi GX, Han J, Andres DA
J Biol Chem. 2005
PubMed ID: 16157584
[Effect on apoptosis of anterior pituitary induced by cadmium chloride and its relations with p38 MAPK & ERK1/2 passway]
Yang XF, Zhu W, Wei Q, Lin ZN
Wei Sheng Yan Jiu. 2005
PubMed ID: 16535835
Phorbol myristate acetate induces neutrophil death through activation of p38 mitogen-activated protein kinase that requires endogenous reactive oxygen species other than HOCl.
Saito T, Takahashi H, Doken H, Koyama H, Aratani Y
Biosci Biotechnol Biochem. 2005
PubMed ID: 16306704
Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells.
Kwon SJ, Song JJ, Lee YJ
Clin Cancer Res. 2005
PubMed ID: 16278378
Role of p38 mitogen-activated protein kinase on renal dysfunction after hemorrhagic shock in rats.
Sato H, Tanaka T, Kasai K, Kita T, Tanaka N
Shock. 2005
PubMed ID: 16247337
Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin II.
Endoh T
J Physiol. 2005
PubMed ID: 16123104
Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms.
Ryer EJ, Sakakibara K, Wang C, Sarkar D, Fisher PB, Faries PL, Kent KC, Liu B
J Biol Chem. 2005
PubMed ID: 16118209
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Lee MJ, Tasaki T, Moroi K, An JY, Kimura S, Davydov IV, Kwon YT
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16217033
A3 adenosine receptors modulate hypoxia-inducible factor-1alpha expression in human A375 melanoma cells.
Merighi S, Benini A, Mirandola P, Gessi S, Varani K, Leung E, MacLennan S, Baraldi PG, Borea PA
Neoplasia. 2005
PubMed ID: 16242072
Virus-induced inhibition of CD1d1-mediated antigen presentation: reciprocal regulation by p38 and ERK.
Renukaradhya GJ, Webb TJ, Khan MA, Lin YL, Du W, Gervay-Hague J, Brutkiewicz RR
J Immunol. 2005
PubMed ID: 16177070
Activation of p38 stress-activated protein kinase during Rickettsia rickettsii infection of human endothelial cells: role in the induction of chemokine response.
Rydkina E, Silverman DJ, Sahni SK
Cell Microbiol. 2005
PubMed ID: 16153249
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells.
Jirmanova L, Bulavin DV, Fornace AJ
Cell Cycle. 2005
PubMed ID: 16138010
Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.
Ogborne RM, Rushworth SA, O'Connell MA
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 16123320
T-cadherin protects endothelial cells from oxidative stress-induced apoptosis.
Joshi MB, Philippova M, Ivanov D, Allenspach R, Erne P, Resink TJ
FASEB J. 2005
PubMed ID: 16099944
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.
Lee C, Tomkowicz B, Freedman BD, Collman RG
J Leukoc Biol. 2005
PubMed ID: 16081599
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.
Macé G, Miaczynska M, Zerial M, Nebreda AR
EMBO J. 2005
PubMed ID: 16138080
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells.
Herrera B, Carracedo A, Diez-Zaera M, Guzmán M, Velasco G
FEBS Lett. 2005
PubMed ID: 16139274
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.
Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M
Immunity. 2005
PubMed ID: 16169504
Kinetic mechanism for p38 MAP kinase alpha. A partial rapid-equilibrium random-order ternary-complex mechanism for the phosphorylation of a protein substrate.
Szafranska AE, Dalby KN
FEBS J. 2005
PubMed ID: 16156785
The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development.
Christie GR, Williams DJ, Macisaac F, Dickinson RJ, Rosewell I, Keyse SM
Mol Cell Biol. 2005
PubMed ID: 16135819
Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor.
Zheng FF, Wu RC, Smith CL, O'Malley BW
Mol Cell Biol. 2005
PubMed ID: 16135815
Purinergic receptor modulation of BV-2 microglial cell activity: potential involvement of p38 MAP kinase and CREB.
Brautigam VM, Frasier C, Nikodemova M, Watters JJ
J Neuroimmunol. 2005
PubMed ID: 15979729
IL-6 induces neuroendocrine dedifferentiation and cell proliferation in non-small cell lung cancer cells.
Chang KT, Tsai CM, Chiou YC, Chiu CH, Jeng KS, Huang CY
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 15894558
Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways.
An SS, Pennella CM, Gonnabathula A, Chen J, Wang N, Gaestel M, Hassoun PM, Fredberg JJ, Kayyali US
Am J Physiol Cell Physiol. 2005
PubMed ID: 15857906
Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5.
Moro T, Ogasawara T, Chikuda H, Ikeda T, Ogata N, Maruyama Z, Komori T, Hoshi K, Chung UI, Nakamura K, Okayama H, Kawaguchi H
J Cell Physiol. 2005
PubMed ID: 15795936
Involvement of extracellular regulated kinase and p38 kinase in hippocampal seizure tolerance.
Jiang W, Van Cleemput J, Sheerin AH, Ji SP, Zhang Y, Saucier DM, Corcoran ME, Zhang X
J Neurosci Res. 2005
PubMed ID: 15948190
Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling.
Song IS, Tatebe S, Dai W, Kuo MT
J Biol Chem. 2005
PubMed ID: 15946948
Direct phosphorylation of proliferative and survival pathway proteins by RET.
Panta GR, Du L, Nwariaku FE, Kim LT
Surgery. 2005
PubMed ID: 16153436
Increased phosphorylation and activation of mitogen-activated protein kinase p38 in scleroderma fibroblasts.
Ihn H, Yamane K, Tamaki K
J Invest Dermatol. 2005
PubMed ID: 16098034
p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development.
Paliga AJ, Natale DR, Watson AJ
Biol Cell. 2005
PubMed ID: 15850458
A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death.
Auger R, Motta I, Benihoud K, Ojcius DM, Kanellopoulos JM
J Biol Chem. 2005
PubMed ID: 15937334
Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.
Butler MP, Hanly JA, Moynagh PN
J Biol Chem. 2005
PubMed ID: 15917247
Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.
Thiefes A, Wolter S, Mushinski JF, Hoffmann E, Dittrich-Breiholz O, Graue N, Dörrie A, Schneider H, Wirth D, Luckow B, Resch K, Kracht M
J Biol Chem. 2005
PubMed ID: 15837794
Nitric oxide induces prion protein via MEK and p38 MAPK signaling.
Wang V, Chuang TC, Hsu YD, Chou WY, Kao MC
Biochem Biophys Res Commun. 2005
PubMed ID: 15936714
Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2.
Anwar AA, Li FY, Leake DS, Ishii T, Mann GE, Siow RC
Free Radic Biol Med. 2005
PubMed ID: 15964514
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Terakawa M, Tomimori Y, Goto M, Hayashi Y, Oikawa S, Fukuda Y
Biochem Biophys Res Commun. 2005
PubMed ID: 15919053
Differential Involvement of ERK2 and p38 in platelet adhesion to collagen.
Mazharian A, Roger S, Maurice P, Berrou E, Popoff MR, Hoylaerts MF, Fauvel-Lafeve F, Bonnefoy A, Bryckaert M
J Biol Chem. 2005
PubMed ID: 15851480
Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.
Wittmack EK, Rush AM, Hudmon A, Waxman SG, Dib-Hajj SD
J Neurosci. 2005
PubMed ID: 16014723
Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM
J Proteome Res. 2005
PubMed ID: 16083285
Lipopolysaccharide: a p38 MAPK-dependent disrupter of neutrophil chemotaxis.
Khan AI, Heit B, Andonegui G, Colarusso P, Kubes P
Microcirculation. 2005
PubMed ID: 16020390
p38 mitogen-activated protein kinase contributes to cell cycle regulation by cAMP in FRTL-5 thyroid cells.
Corrèze C, Blondeau JP, Pomérance M
Eur J Endocrinol. 2005
PubMed ID: 15994754
HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21.
Badr G, Borhis G, Treton D, Moog C, Garraud O, Richard Y
J Immunol. 2005
PubMed ID: 15972662
Reduced p38 mitogen-activated protein kinase in donor grafts accelerates acute intestinal graft-versus-host disease in mice.
Ohta M, Tateishi K, Kanai F, Ueha S, Guleng B, Washida M, Tanaka Y, Ijichi H, Ikenoue T, Sata M, Sudo T, Shiina S, Kawabe T, Matsushima K, Omata M
Eur J Immunol. 2005
PubMed ID: 15971269
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
Mol Cell Biol. 2005
PubMed ID: 15964803
Lipoteichoic acid induces nuclear factor-kappaB activation and nitric oxide synthase expression via phosphatidylinositol 3-kinase, Akt, and p38 MAPK in RAW 264.7 macrophages.
Kao SJ, Lei HC, Kuo CT, Chang MS, Chen BC, Chang YC, Chiu WT, Lin CH
Immunology. 2005
PubMed ID: 15946254
Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells.
Wang JM, Tseng JT, Chang WC
Mol Biol Cell. 2005
PubMed ID: 15901830
Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway.
de Angelis L, Zhao J, Andreucci JJ, Olson EN, Cossu G, McDermott JC
Dev Biol. 2005
PubMed ID: 15890335
TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway.
Lokuta MA, Huttenlocher A
J Leukoc Biol. 2005
PubMed ID: 15845648
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ
Mol Biol Cell. 2005
PubMed ID: 15843433
AP-1 mediates beta-amyloid-induced iNOS expression in PC12 cells via the ERK2 and p38 MAPK signaling pathways.
Jang JH, Surh YJ
Biochem Biophys Res Commun. 2005
PubMed ID: 15883033
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Shu E, Matsuno H, Akamastu S, Kanno Y, Suga H, Nakajima K, Ishisaki A, Takai S, Kato K, Kitajima Y, Kozawa O
Arch Biochem Biophys. 2005
PubMed ID: 15907784
Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.
Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K, Takai S, Akamatsu S, Kato K, Oiso Y, Kozawa O
Arch Biochem Biophys. 2005
PubMed ID: 15896702
Regulation of the cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells.
Moolwaney AS, Igwe OJ
Brain Res Mol Brain Res. 2005
PubMed ID: 15950779
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes.
Wijayanti N, Kietzmann T, Immenschuh S
J Biol Chem. 2005
PubMed ID: 15833736
p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury.
Zhuang S, Yan Y, Han J, Schnellmann RG
J Biol Chem. 2005
PubMed ID: 15797859
Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.
McMullen ME, Bryant PW, Glembotski CC, Vincent PA, Pumiglia KM
J Biol Chem. 2005
PubMed ID: 15790570
Methylglyoxal induces apoptosis through oxidative stress-mediated activation of p38 mitogen-activated protein kinase in rat Schwann cells.
Fukunaga M, Miyata S, Higo S, Hamada Y, Ueyama S, Kasuga M
Ann N Y Acad Sci. 2005
PubMed ID: 16037234
Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice.
Kim AL, Labasi JM, Zhu Y, Tang X, McClure K, Gabel CA, Athar M, Bickers DR
J Invest Dermatol. 2005
PubMed ID: 15955110
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS
J Cell Sci. 2005
PubMed ID: 15923648
Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling.
Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ, Chandel NS
Mol Cell Biol. 2005
PubMed ID: 15923604
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nishitoh H, Nagai S, Koyasu S, Matsumoto K, Takeda K, Ichijo H
Nat Immunol. 2005
PubMed ID: 15864310
Thyroid hormone induces cardiac myocyte hypertrophy in a thyroid hormone receptor alpha1-specific manner that requires TAK1 and p38 mitogen-activated protein kinase.
Kinugawa K, Jeong MY, Bristow MR, Long CS
Mol Endocrinol. 2005
PubMed ID: 15831522
p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.
Miller AL, Webb MS, Copik AJ, Wang Y, Johnson BH, Kumar R, Thompson EB
Mol Endocrinol. 2005
PubMed ID: 15817653
Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway.
Lin HH, Huang HP, Huang CC, Chen JH, Wang CJ
Mol Carcinog. 2005
PubMed ID: 15791651
p38 MAPK/HSP25 signaling mediates cadmium-induced contraction of mesangial cells and renal glomeruli.
Hirano S, Sun X, DeGuzman CA, Ransom RF, McLeish KR, Smoyer WE, Shelden EA, Welsh MJ, Benndorf R
Am J Physiol Renal Physiol. 2005
PubMed ID: 15687248
Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.
Holasek SS, Wengenack TM, Kandimalla KK, Montano C, Gregor DM, Curran GL, Poduslo JF
Brain Res. 2005
PubMed ID: 15910777
A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.
Longo-Guess CM, Gagnon LH, Cook SA, Wu J, Zheng QY, Johnson KR
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15905332
Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.
Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z
J Biol Chem. 2005
PubMed ID: 15767263
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, Keating MT
Genes Dev. 2005
PubMed ID: 15870258
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.
Huang C, Thirone AC, Huang X, Klip A
J Biol Chem. 2005
PubMed ID: 15764603
Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway.
Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay MA, Canessa CM, Pittet JF
J Biol Chem. 2005
PubMed ID: 15755725
Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.
Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind JS, Coso OA
J Biol Chem. 2005
PubMed ID: 15708845
Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase.
Liang YC, Wu CH, Chu JS, Wang CK, Hung LF, Wang YJ, Ho YS, Chang JG, Lin SY
World J Gastroenterol. 2005
PubMed ID: 15849811
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Tamayo N, Liao L, Goldberg M, Powers D, Tudor YY, Yu V, Wong LM, Henkle B, Middleton S, Syed R, Harvey T, Jang G, Hungate R, Dominguez C
Bioorg Med Chem Lett. 2005
PubMed ID: 15837335
The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ
Bioorg Med Chem Lett. 2005
PubMed ID: 15837333
The development of monocyclic pyrazolone based cytokine synthesis inhibitors.
Golebiowski A, Townes JA, Laufersweiler MJ, Brugel TA, Clark MP, Clark CM, Djung JF, Laughlin SK, Sabat MP, Bookland RG, VanRens JC, De B, Hsieh LC, Janusz MJ, Walter RL, Webster ME, Mekel MJ
Bioorg Med Chem Lett. 2005
PubMed ID: 15837310
Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter.
Ylisastigui L, Kaur R, Johnson H, Volker J, He G, Hansen U, Margolis D
J Virol. 2005
PubMed ID: 15857981
A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad.
Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, Shimada K, Morohashi K
Genes Cells. 2005
PubMed ID: 15836771
p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes.
Yamamoto T, Kojima T, Murata M, Takano K, Go M, Hatakeyama N, Chiba H, Sawada N
J Hepatol. 2005
PubMed ID: 15826721
B lymphocyte stimulator activates p38 mitogen-activated protein kinase in human Ig class switch recombination.
Yamada T, Zhang K, Yamada A, Zhu D, Saxon A
Am J Respir Cell Mol Biol. 2005
PubMed ID: 15668322
Activation of p38 MAPKalpha by extracellular pressure mediates the stimulation of macrophage phagocytosis by pressure.
Shiratsuchi H, Basson MD
Am J Physiol Cell Physiol. 2005
PubMed ID: 15625302
Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK.
Hildesheim J, Salvador JM, Hollander MC, Fornace AJ
J Biol Chem. 2005
PubMed ID: 15649893
The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation.
Vockerodt M, Pinkert D, Smola-Hess S, Michels A, Ransohoff RM, Tesch H, Kube D
Int J Cancer. 2005
PubMed ID: 15578697
Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.
Hollenbach E, Vieth M, Roessner A, Neumann M, Malfertheiner P, Naumann M
J Biol Chem. 2005
PubMed ID: 15691843
H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.
Shin I, Kim S, Song H, Kim HR, Moon A
J Biol Chem. 2005
PubMed ID: 15677464
The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell.
Jones NC, Tyner KJ, Nibarger L, Stanley HM, Cornelison DD, Fedorov YV, Olwin BB
J Cell Biol. 2005
PubMed ID: 15824134
p38 MAPK-dependent and YY1-mediated chemokine receptors CCR5 and CXCR4 up-regulation in U937 cell line infected by Mycobacterium tuberculosis or Actinobacillus actinomycetemcomitans.
Lei J, Wu C, Wang X, Wang H
Biochem Biophys Res Commun. 2005
PubMed ID: 15737629
[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.
Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ
Oncogene. 2005
PubMed ID: 15735738
Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction.
Ren J, Zhang S, Kovacs A, Wang Y, Muslin AJ
J Mol Cell Cardiol. 2005
PubMed ID: 15808838
Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor.
Otun HA, MacDougall MW, Bailey J, Europe-Finner GN, Robson SC
J Soc Gynecol Investig. 2005
PubMed ID: 15784503
Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.
Inoue T, Hammaker D, Boyle DL, Firestein GS
J Immunol. 2005
PubMed ID: 15778394
p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection.
Kim L, Del Rio L, Butcher BA, Mogensen TH, Paludan SR, Flavell RA, Denkers EY
J Immunol. 2005
PubMed ID: 15778378
The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed.
Riol-Blanco L, Sánchez-Sánchez N, Torres A, Tejedor A, Narumiya S, Corbí AL, Sánchez-Mateos P, Rodríguez-Fernández JL
J Immunol. 2005
PubMed ID: 15778365
Requirement of the MAP kinase signaling pathways for mouse preimplantation development.
Maekawa M, Yamamoto T, Tanoue T, Yuasa Y, Chisaka O, Nishida E
Development. 2005
PubMed ID: 15772134
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
Kelkar N, Standen CL, Davis RJ
Mol Cell Biol. 2005
PubMed ID: 15767678
Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation.
Nishio S, Hatano M, Nagata M, Horie S, Koike T, Tokuhisa T, Mochizuki T
J Clin Invest. 2005
PubMed ID: 15761494
Human placental lipid induces melanogenesis through p38 MAPK in B16F10 mouse melanoma.
Singh SK, Sarkar C, Mallick S, Saha B, Bera R, Bhadra R
Pigment Cell Res. 2005
PubMed ID: 15760340
The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ, Ashwell JD
Nat Immunol. 2005
PubMed ID: 15735649
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ, Ashwell JD
Nat Immunol. 2005
PubMed ID: 15735648
Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.
Shin HJ, Oh J, Kang SM, Lee JH, Shin MJ, Hwang KC, Jang Y, Chung JH
Biochem Biophys Res Commun. 2005
PubMed ID: 15721267
Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cells.
Kageyama K, Hanada K, Suda T
Regul Pept. 2005
PubMed ID: 15664670
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT
Oncogene. 2005
PubMed ID: 15688026
Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.
Gardner OS, Shiau CW, Chen CS, Graves LM
J Biol Chem. 2005
PubMed ID: 15649892
SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells.
Tsukada S, Westwick JK, Ikejima K, Sato N, Rippe RA
J Biol Chem. 2005
PubMed ID: 15647278
Morphine potentiates HIV-1 gp120-induced neuronal apoptosis.
Hu S, Sheng WS, Lokensgard JR, Peterson PK
J Infect Dis. 2005
PubMed ID: 15717263
Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury.
Zhang X, Shan P, Alam J, Fu XY, Lee PJ
J Biol Chem. 2005
PubMed ID: 15590660
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription.
Lluís F, Ballestar E, Suelves M, Esteller M, Muñoz-Cánoves P
EMBO J. 2005
PubMed ID: 15719023
p38 mitogen-activated protein kinase downregulates endothelial progenitor cells.
Seeger FH, Haendeler J, Walter DH, Rochwalsky U, Reinhold J, Urbich C, Rössig L, Corbaz A, Chvatchko Y, Zeiher AM, Dimmeler S
Circulation. 2005
PubMed ID: 15753227
Differential phosphorylation of p38 induced by apoptotic and anti-apoptotic stimuli in murine hepatocytes.
Guo LX, Xie H
World J Gastroenterol. 2005
PubMed ID: 15761973
The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.
Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y
J Biol Chem. 2005
PubMed ID: 15590669
TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle.
Li YP, Chen Y, John J, Moylan J, Jin B, Mann DL, Reid MB
FASEB J. 2005
PubMed ID: 15746179
Activation of p38 and N-acetylcysteine-sensitive c-Jun NH2-terminal kinase signaling cascades is required for induction of apoptosis in Parkinson's disease cybrids.
Onyango IG, Tuttle JB, Bennett JP
Mol Cell Neurosci. 2005
PubMed ID: 15737736
Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK.
Canfield S, Lee Y, Schröder A, Rothman P
J Immunol. 2005
PubMed ID: 15728454
p38 kinase mediates nitric oxide-induced apoptosis of chondrocytes through the inhibition of protein kinase C zeta by blocking autophosphorylation.
Kim JS, Park ZY, Yoo YJ, Yu SS, Chun JS
Cell Death Differ. 2005
PubMed ID: 15665819
Regulation of GDF-8 signaling by the p38 MAPK.
Philip B, Lu Z, Gao Y
Cell Signal. 2005
PubMed ID: 15567067
Acute adenosine preconditioning is mediated by p38 MAPK activation in discrete subcellular compartments.
Ballard-Croft C, Kristo G, Yoshimura Y, Reid E, Keith BJ, Mentzer RM, Lasley RD
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15539417
Static stretch promotes MEF2A nuclear translocation and expression of neonatal myosin heavy chain in C2C12 myocytes in a calcineurin- and p38-dependent manner.
Rauch C, Loughna PT
Am J Physiol Cell Physiol. 2005
PubMed ID: 15483225
Statins suppress oxidized low density lipoprotein-induced macrophage proliferation by inactivation of the small G protein-p38 MAPK pathway.
Senokuchi T, Matsumura T, Sakai M, Yano M, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Imoto K, Nishikawa T, Kim-Mitsuyama S, Takuwa Y, Araki E
J Biol Chem. 2005
PubMed ID: 15611087
Smooth muscle actin determines mechanical force-induced p38 activation.
Wang J, Fan J, Laschinger C, Arora PD, Kapus A, Seth A, McCulloch CA
J Biol Chem. 2005
PubMed ID: 15591055
Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.
Scherberich A, Tucker RP, Degen M, Brown-Luedi M, Andres AC, Chiquet-Ehrismann R
Oncogene. 2005
PubMed ID: 15592496
Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3.
Alvarado-Kristensson M, Andersson T
J Biol Chem. 2005
PubMed ID: 15569672
The p38 SAPK pathway is required for Ha-ras induced in vitro invasion of NIH3T3 cells.
Behren A, Binder K, Vucelic G, Herberhold S, Hirt B, Loewenheim H, Preyer S, Zenner HP, Simon C
Exp Cell Res. 2005
PubMed ID: 15652346
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
McCormick C, Ganem D
Science. 2005
PubMed ID: 15692053
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G, Flavell RA
Science. 2005
PubMed ID: 15692051
Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.
Kaur R, Liu X, Gjoerup O, Zhang A, Yuan X, Balk SP, Schneider MC, Lu ML
J Biol Chem. 2005
PubMed ID: 15550393
Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway.
St-Laurent V, Sanchez M, Charbonneau C, Tremblay A
J Steroid Biochem Mol Biol. 2005
PubMed ID: 15862947
MAPK p38 alpha is dispensable for lymphocyte development and proliferation.
Kim JM, White JM, Shaw AS, Sleckman BP
J Immunol. 2005
PubMed ID: 15661878
Aggravation of focal cerebral ischemia by tissue plasminogen activator is reversed by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor but does not depend on endothelial NO synthase.
Kilic E, Kilic U, Matter CM, Lüscher TF, Bassetti CL, Hermann DM
Stroke. 2005
PubMed ID: 15625301
MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation.
Wang Q, Yerukhimovich M, Gaarde WA, Popoff IJ, Doerschuk CM
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 15516490
VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium.
Woo CH, Lim JH, Kim JH
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 15489375
Fragment-based lead discovery using X-ray crystallography.
Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H
J Med Chem. 2005
PubMed ID: 15658854
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope.
Perfettini JL, Castedo M, Nardacci R, Ciccosanti F, Boya P, Roumier T, Larochette N, Piacentini M, Kroemer G
J Exp Med. 2005
PubMed ID: 15642743
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation.
Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, Yaffe MB
Mol Cell. 2005
PubMed ID: 15629715
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression.
Samuvel DJ, Jayanthi LD, Bhat NR, Ramamoorthy S
J Neurosci. 2005
PubMed ID: 15634764
Tumour necrosis factor activates the mitogen-activated protein kinases p38alpha and ERK in the synovial membrane in vivo.
Görtz B, Hayer S, Tuerck B, Zwerina J, Smolen JS, Schett G
Arthritis Res Ther. 2005
PubMed ID: 16207331
Induction of p38- and gC1qR-dependent IL-8 expression in pulmonary fibroblasts by soluble hepatitis C core protein.
Moorman JP, Fitzgerald SM, Prayther DC, Lee SA, Chi DS, Krishnaswamy G
Respir Res. 2005
PubMed ID: 16164755
Regulation of synthesis of osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand in normal human osteoblasts via the p38 mitogen-activated protein kinase pathway by the application of cyclic tensile strain.
Kusumi A, Sakaki H, Kusumi T, Oda M, Narita K, Nakagawa H, Kubota K, Satoh H, Kimura H
J Bone Miner Metab. 2005
PubMed ID: 16133687
Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons.
Singh IN, El-Hage N, Campbell ME, Lutz SE, Knapp PE, Nath A, Hauser KF
Neuroscience. 2005
PubMed ID: 16111829
Mitogen-activated protein kinases (p38 and c-Jun NH2-terminal kinase) are differentially regulated during cardiac volume and pressure overload hypertrophy.
Sopontammarak S, Aliharoob A, Ocampo C, Arcilla RA, Gupta MP, Gupta M
Cell Biochem Biophys. 2005
PubMed ID: 16043884
Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor.
Tamura S, Morikawa Y, Senba E
Neuroscience. 2005
PubMed ID: 15893881
Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction.
Chen H, Brahmbhatt S, Gupta A, Sharma AC
Cardiovasc Diabetol. 2005
PubMed ID: 15748291
Atrial natriuretic peptide effects on intracellular pH changes and ROS production in HEPG2 cells: role of p38 MAPK and phospholipase D.
Baldini PM, De Vito P, Vismara D, Bagni C, Zalfa F, Minieri M, Di Nardo P
Cell Physiol Biochem. 2005
PubMed ID: 15665518
Redox regulation of p38 MAPK activation and expression of ICAM-1 and heme oxygenase-1 in human alveolar epithelial (A549) cells.
Bundy RE, Hoare GS, Kite A, Beach J, Yacoub M, Marczin N
Antioxid Redox Signal. 2005
PubMed ID: 15650392
H2O2-induced proliferation of primary alveolar epithelial cells is mediated by MAP kinases.
Sigaud S, Evelson P, González-Flecha B
Antioxid Redox Signal. 2005
PubMed ID: 15650391
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.
Shi GX, Andres DA
Mol Cell Biol. 2005
PubMed ID: 15632082
Administration of ricin induces a severe inflammatory response via nonredundant stimulation of ERK, JNK, and P38 MAPK and provides a mouse model of hemolytic uremic syndrome.
Korcheva V, Wong J, Corless C, Iordanov M, Magun B
Am J Pathol. 2005
PubMed ID: 15632024
Congenital hypothyroidism alters the phosphorylation of ERK1/2 and p38MAPK in the hippocampus of neonatal rats.
Calloni GW, Penno CA, Cordova FM, Trentin AG, Neto VM, Leal RB
Brain Res Dev Brain Res. 2005
PubMed ID: 15617763
MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.
Zhang L, Deng M, Parthasarathy R, Wang L, Mongan M, Molkentin JD, Zheng Y, Xia Y
Mol Cell Biol. 2005
PubMed ID: 15601830
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1.
Ha HY, Cho IH, Lee KW, Lee KW, Song JY, Kim KS, Yu YM, Lee JK, Song JS, Yang SD, Shin HS, Han PL
Dev Biol. 2005
PubMed ID: 15572149
p38 MAP kinase inhibitor reverses stress-induced cardiac myocyte dysfunction.
Kan H, Birkle D, Jain AC, Failinger C, Xie S, Finkel MS
J Appl Physiol. 2005
PubMed ID: 15465893
Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells.
Mavropoulos A, Sully G, Cope AP, Clark AR
Blood. 2005
PubMed ID: 15345584
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.
Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, Hocke AC, Opitz B, Hoffmann E, Kracht M, Zerrahn J, Hammerschmidt S, Rosseau S, Suttorp N, Hippenstiel S
J Biol Chem. 2004
PubMed ID: 15485852
Neurotoxic prostaglandin J2 enhances cyclooxygenase-2 expression in neuronal cells through the p38MAPK pathway: a death wish?
Li Z, Jansen M, Ogburn K, Salvatierra L, Hunter L, Mathew S, Figueiredo-Pereira ME
J Neurosci Res. 2004
PubMed ID: 15523637
p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells.
Pisegna S, Pirozzi G, Piccoli M, Frati L, Santoni A, Palmieri G
Blood. 2004
PubMed ID: 15315972
Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK.
Korporaal SJ, Relou IA, van Eck M, Strasser V, Bezemer M, Gorter G, van Berkel TJ, Nimpf J, Akkerman JW, Lenting PJ
J Biol Chem. 2004
PubMed ID: 15459198
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Activation of mitogen activated protein kinases via complement receptor type 2.
Luo MH, Chen ML, Stoiber H, Dierich MP
Chin Med J (Engl). 2004
PubMed ID: 15603708
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K
Mol Cell Biol. 2004
PubMed ID: 15572667
Diminished ERK 1/2 and p38 MAPK phosphorylation in skeletal muscle during sepsis.
Vary TC, Deiter G, Lang CH
Shock. 2004
PubMed ID: 15545827
Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression.
Wang WH, Grégori G, Hullinger RL, Andrisani OM
Mol Cell Biol. 2004
PubMed ID: 15542843
Interaction of Neisseria meningitidis with human brain microvascular endothelial cells: role of MAP- and tyrosine kinases in invasion and inflammatory cytokine release.
Sokolova O, Heppel N, Jägerhuber R, Kim KS, Frosch M, Eigenthaler M, Schubert-Unkmeir A
Cell Microbiol. 2004
PubMed ID: 15527495
The p38 pathway regulates Akt both at the protein and transcriptional activation levels during myogenesis.
Cabane C, Coldefy AS, Yeow K, Dérijard B
Cell Signal. 2004
PubMed ID: 15381256
Basic fibroblast growth factor-induced cell death is effected through sustained activation of p38MAPK and up-regulation of the death receptor p75NTR.
Williamson AJ, Dibling BC, Boyne JR, Selby P, Burchill SA
J Biol Chem. 2004
PubMed ID: 15310753
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A, Noguchi K
J Neurosci. 2004
PubMed ID: 15537893
Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase.
Hung JH, Su IJ, Lei HY, Wang HC, Lin WC, Chang WT, Huang W, Chang WC, Chang YS, Chen CC, Lai MD
J Biol Chem. 2004
PubMed ID: 15319438
Active mutants of the human p38alpha mitogen-activated protein kinase.
Diskin R, Askari N, Capone R, Engelberg D, Livnah O
J Biol Chem. 2004
PubMed ID: 15284239
Bartonella quintana-induced apoptosis inhibition of human endothelial cells is associated with p38 and SAPK/JNK modulation and with stimulation of mitosis.
Liberto MC, Matera G, Lamberti AG, Barreca GS, Focà D, Quirino A, Soria MR, Focà A
Diagn Microbiol Infect Dis. 2004
PubMed ID: 15541600
Shock waves increase T-cell proliferation or IL-2 expression by activating p38 MAP kinase.
Yu TC, Liu Y, Tan Y, Jiang Y, Zheng X, Xu X
Acta Biochim Biophys Sin (Shanghai). 2004
PubMed ID: 15514847
Serine-threonine kinases and transcription factors active in signal transduction are detected at high levels of phosphorylation during mitosis in preimplantation embryos and trophoblast stem cells.
Liu J, Puscheck EE, Wang F, Trostinskaia A, Barisic D, Maniere G, Wygle D, Zhong W, Rings EH, Rappolee DA
Reproduction. 2004
PubMed ID: 15509711
Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis.
Maitra SR, Bhaduri S, Chen E, Shapiro MJ
Shock. 2004
PubMed ID: 15489642
Adrenergic regulation and diurnal rhythm of p38 mitogen-activated protein kinase phosphorylation in the rat pineal gland.
Chik CL, Mackova M, Price D, Ho AK
Endocrinology. 2004
PubMed ID: 15297444
cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells.
Rahman A, Anwar KN, Minhajuddin M, Bijli KM, Javaid K, True AL, Malik AB
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15246972
p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs.
Cheung PY, Zhang Y, Long J, Lin S, Zhang M, Jiang Y, Wu Z
J Biol Chem. 2004
PubMed ID: 15375157
Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1.
Matsumoto M, Kogawa M, Wada S, Takayanagi H, Tsujimoto M, Katayama S, Hisatake K, Nogi Y
J Biol Chem. 2004
PubMed ID: 15304486
Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling.
Frey MR, Golovin A, Polk DB
J Biol Chem. 2004
PubMed ID: 15316018
Oxidants inhibit ERK/MAPK and prevent its ability to delay neutrophil apoptosis downstream of mitochondrial changes and at the level of XIAP.
Gardai SJ, Whitlock BB, Xiao YQ, Bratton DB, Henson PM
J Biol Chem. 2004
PubMed ID: 15292176
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.
Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE
Cell. 2004
PubMed ID: 15479644
Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase.
Szatmáry Z, Garabedian MJ, Vilcek J
J Biol Chem. 2004
PubMed ID: 15292225
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
TRAF6-dependent mitogen-activated protein kinase activation differentially regulates the production of interleukin-12 by macrophages in response to Toxoplasma gondii.
Mason NJ, Fiore J, Kobayashi T, Masek KS, Choi Y, Hunter CA
Infect Immun. 2004
PubMed ID: 15385464
Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression.
Wijayanti N, Huber S, Samoylenko A, Kietzmann T, Immenschuh S
Antioxid Redox Signal. 2004
PubMed ID: 15345139
Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease.
Hollenbach E, Neumann M, Vieth M, Roessner A, Malfertheiner P, Naumann M
FASEB J. 2004
PubMed ID: 15289440
Mitogen-activated protein kinases Erk1/2 and p38 are required for maximal regulation of TIMP-1 by oncostatin M in murine fibroblasts.
Tong L, Smyth D, Kerr C, Catterall J, Richards CD
Cell Signal. 2004
PubMed ID: 15240007
Exip, a splicing variant of p38alpha, participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway.
Yagasaki Y, Sudo T, Osada H
FEBS Lett. 2004
PubMed ID: 15388348
Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts.
Uekawa N, Nishikimi A, Isobe K, Iwakura Y, Maruyama M
FEBS Lett. 2004
PubMed ID: 15388329
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai MJ, O'Malley BW
Mol Cell. 2004
PubMed ID: 15383283
Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.
Shin J, Park B, Cho S, Lee S, Kim Y, Lee SO, Cho K, Lee S, Jin BS, Ahn JH, Choi EJ, Ahn K
J Biol Chem. 2004
PubMed ID: 15273249
Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-alpha induction of p38 and p42/p44 mitogen-activated protein kinases.
Hernandez R, Teruel T, de Alvaro C, Lorenzo M
Diabetologia. 2004
PubMed ID: 15365619
Mycobacterium tuberculosis triggers apoptosis in peripheral neutrophils involving toll-like receptor 2 and p38 mitogen protein kinase in tuberculosis patients.
Alemán M, Schierloh P, de la Barrera SS, Musella RM, Saab MA, Baldini M, Abbate E, Sasiain MC
Infect Immun. 2004
PubMed ID: 15322009
p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes.
Engelbrecht AM, Niesler C, Page C, Lochner A
Basic Res Cardiol. 2004
PubMed ID: 15309413
Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38.
Jans R, Atanasova G, Jadot M, Poumay Y
J Invest Dermatol. 2004
PubMed ID: 15304097
Smad and p38-MAPK signaling mediates apoptotic effects of transforming growth factor-beta1 in human airway epithelial cells.
Undevia NS, Dorscheid DR, Marroquin BA, Gugliotta WL, Tse R, White SR
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15132952
Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death.
Cao J, Semenova MM, Solovyan VT, Han J, Coffey ET, Courtney MJ
J Biol Chem. 2004
PubMed ID: 15192112
Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death.
Oh HM, Choi SC, Lee HS, Chun CH, Seo GS, Choi EY, Lee HJ, Lee MS, Yeom JJ, Choi SJ, Han WC, Oh JM, Chung YT, Chun JS, Lee KM, Jun CD
Free Radic Biol Med. 2004
PubMed ID: 15256218
Catalysis and function of the p38 alpha.MK2a signaling complex.
Lukas SM, Kroe RR, Wildeson J, Peet GW, Frego L, Davidson W, Ingraham RH, Pargellis CA, Labadia ME, Werneburg BG
Biochemistry. 2004
PubMed ID: 15287722
Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells.
Wang L, Kwak JH, Kim SI, He Y, Choi ME
J Biol Chem. 2004
PubMed ID: 15143069
Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media.
Palacios SD, Pak K, Rivkin AZ, Kayali AG, Austen D, Aletsee C, Melhus A, Webster NJ, Ryan AF
Infect Immun. 2004
PubMed ID: 15271927
Endotoxin increases plasma soluble tumor necrosis factor-related apoptosis-inducing ligand level mediated by the p38 mitogen-activated protein kinase signaling pathway.
Lub-de Hooge MN, de Jong S, Vermot-Desroches C, Tulleken JE, de Vries EG, Zijlstra JG
Shock. 2004
PubMed ID: 15257094
p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells.
Nakagawa S, Ohtani T, Mizuashi M, Mollah ZU, Ito Y, Tagami H, Aiba S
J Invest Dermatol. 2004
PubMed ID: 15245437
Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells.
Taniyama Y, Ushio-Fukai M, Hitomi H, Rocic P, Kingsley MJ, Pfahnl C, Weber DS, Alexander RW, Griendling KK
Am J Physiol Cell Physiol. 2004
PubMed ID: 15084475
MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis.
Page JL, Wang X, Sordillo LM, Johnson SE
J Biol Chem. 2004
PubMed ID: 15159407
Evidence for a role of MSK1 in transforming growth factor-beta-mediated responses through p38alpha and Smad signaling pathways.
Abécassis L, Rogier E, Vazquez A, Atfi A, Bourgeade MF
J Biol Chem. 2004
PubMed ID: 15133024
Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.
Liu Q, Chen T, Chen H, Zhang M, Li N, Lu Z, Ma P, Cao X
Biochem Biophys Res Commun. 2004
PubMed ID: 15184078
Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductase.
Price SA, Agthong S, Middlemas AB, Tomlinson DR
Diabetes. 2004
PubMed ID: 15220210
Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart.
Tenhunen O, Sármán B, Kerkelä R, Szokodi I, Papp L, Tóth M, Ruskoaho H
J Biol Chem. 2004
PubMed ID: 15051723
MD-2: the Toll 'gatekeeper' in endotoxin signalling.
Gangloff M, Gay NJ
Trends Biochem Sci. 2004
PubMed ID: 15276183
Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor.
Santos LL, Lacey D, Yang Y, Leech M, Morand EF
J Rheumatol. 2004
PubMed ID: 15170913
Role of p38 mitogen-activated protein kinase pathway on renal failure in the infant rat after burn injury.
Kita T, Yamaguchi H, Sato H, Kasai K, Tanaka T, Tanaka N
Shock. 2004
PubMed ID: 15167682
Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes.
Liu Q, Hofmann PA
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 14962831
Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK.
Jiang B, Xu S, Hou X, Pimentel DR, Cohen RA
J Biol Chem. 2004
PubMed ID: 15001568
p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts.
Patil C, Zhu X, Rossa C, Kim YJ, Kirkwood KL
Immunol Invest. 2004
PubMed ID: 15195698
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle.
McGee SL, Hargreaves M
Diabetes. 2004
PubMed ID: 15111488
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses.
Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B, Saha B
Nat Med. 2004
PubMed ID: 15107845
p38 mitogen-activated protein kinase contributes to the diminished aortic contraction by endothelin-1 in DOCA-salt hypertensive rats.
Kim B, Kim J, Bae YM, Cho SI, Kwon SC, Jung JY, Park JC, Ahn HY
Hypertension. 2004
PubMed ID: 15051668
Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner.
de Alvaro C, Teruel T, Hernandez R, Lorenzo M
J Biol Chem. 2004
PubMed ID: 14764603
Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo.
Kaiser RA, Bueno OF, Lips DJ, Doevendans PA, Jones F, Kimball TF, Molkentin JD
J Biol Chem. 2004
PubMed ID: 14749328
Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase.
Ma KK, Ogawa T, de Bold AJ
J Mol Cell Cardiol. 2004
PubMed ID: 15081310
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
p38 MAPK signaling during murine preimplantation development.
Natale DR, Paliga AJ, Beier F, D'Souza SJ, Watson AJ
Dev Biol. 2004
PubMed ID: 15031106
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
Mol Cell Biol. 2004
PubMed ID: 15024092
Sgk1 mediates osmotic induction of NPR-A gene in rat inner medullary collecting duct cells.
Chen S, McCormick JA, Prabaker K, Wang J, Pearce D, Gardner DG
Hypertension. 2004
PubMed ID: 15007040
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, Anderson CW, Appella E, Fornace AJ
Nat Genet. 2004
PubMed ID: 14991053
p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6.
Baeza-Raja B, Muñoz-Cánoves P
Mol Biol Cell. 2004
PubMed ID: 14767066
p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton.
Martineau LC, McVeigh LI, Jasmin BJ, Kennedy CR
Am J Physiol Renal Physiol. 2004
PubMed ID: 14665434
p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1.
Hu MC, Wasserman D, Hartwig S, Rosenblum ND
J Biol Chem. 2004
PubMed ID: 14718543
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14985505
Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance.
Kim L, Butcher BA, Denkers EY
J Immunol. 2004
PubMed ID: 14978104
Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR
Mol Cell Biol. 2004
PubMed ID: 14966273
Mechanical stretch induces phosphorylation of p38-MAPK and apoptosis in human saphenous vein.
Cornelissen J, Armstrong J, Holt CM
Arterioscler Thromb Vasc Biol. 2004
PubMed ID: 14715645
Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy.
Tfelt-Hansen J, Chattopadhyay N, Yano S, Kanuparthi D, Rooney P, Schwarz P, Brown EM
Endocrinology. 2004
PubMed ID: 14645111
Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK.
Goral J, Choudhry MA, Kovacs EJ
J Leukoc Biol. 2004
PubMed ID: 14634061
Inhibition of p38 mitogen-activated protein kinase enhances adrenergic-stimulated arylalkylamine N-acetyltransferase activity in rat pinealocytes.
Man JR, Rustaeus S, Price DM, Chik CL, Ho AK
Endocrinology. 2004
PubMed ID: 14617573
Protein kinase C alpha requirement in the activation of p38 mitogen-activated protein kinase, which is linked to the induction of tumor necrosis factor alpha in lipopolysaccharide-stimulated microglia.
Nakajima K, Tohyama Y, Kohsaka S, Kurihara T
Neurochem Int. 2004
PubMed ID: 14602083
Phosphorylation of paxillin by p38MAPK is involved in the neurite extension of PC-12 cells.
Huang C, Borchers CH, Schaller MD, Jacobson K
J Cell Biol. 2004
PubMed ID: 14970194
p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils.
Alvarado-Kristensson M, Melander F, Leandersson K, Rönnstrand L, Wernstedt C, Andersson T
J Exp Med. 2004
PubMed ID: 14970175
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice.
Bendotti C, Atzori C, Piva R, Tortarolo M, Strong MJ, DeBiasi S, Migheli A
J Neuropathol Exp Neurol. 2004
PubMed ID: 14989597
Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus.
Morikawa Y, Ueyama E, Senba E
J Neuroendocrinol. 2004
PubMed ID: 14763996
Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase.
Kubitz R, Sütfels G, Kühlkamp T, Kölling R, Häussinger D
Gastroenterology. 2004
PubMed ID: 14762791
P38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression.
Wang M, Sankula R, Tsai BM, Meldrum KK, Turrentine M, March KL, Brown JW, Dinarello CA, Meldrum DR
Shock. 2004
PubMed ID: 14752292
P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli.
Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR
Mol Biol Cell. 2004
PubMed ID: 14617800
Activation of the ERK1/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes.
Raucci A, Laplantine E, Mansukhani A, Basilico C
J Biol Chem. 2004
PubMed ID: 14593093
Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.
Patel SB, Cameron PM, Frantz-Wattley B, O'Neill E, Becker JW, Scapin G
Biochim Biophys Acta. 2004
PubMed ID: 14726206
Role of p38alpha Map kinase in Type I interferon signaling.
Li Y, Sassano A, Majchrzak B, Deb DK, Levy DE, Gaestel M, Nebreda AR, Fish EN, Platanias LC
J Biol Chem. 2004
PubMed ID: 14578350
Differential regulation of Jun N-terminal kinase and p38MAP kinase by Galpha12.
Dermott JM, Ha JH, Lee CH, Dhanasekaran N
Oncogene. 2004
PubMed ID: 14712227
Role of p38 mitogen-activated protein kinase in thrombus formation.
Sakurai K, Matsuo Y, Sudo T, Takuwa Y, Kimura S, Kasuya Y
J Recept Signal Transduct Res. 2004
PubMed ID: 15648447
Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.
Kim SO, Chun KS, Kundu JK, Surh YJ
Biofactors. 2004
PubMed ID: 15630166
Role of p38 mitogen-activated protein kinase (MAPK) for vacuole formation in lipopolysaccharide (LPS)-stimulated macrophages.
Hassan F, Islam S, Koide N, Mu MM, Ito H, Mori I, Yoshida T, Yokochi T
Microbiol Immunol. 2004
PubMed ID: 15557738
CCK-A receptor induction and P38 and NF-kappaB activation in acute pancreatitis.
Samuel I, Zaheer S, Nelson JJ, Yorek MA, Zaheer A
Pancreatology. 2004
PubMed ID: 14988658
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Interleukin 1alpha (IL-1alpha) induced activation of p38 mitogen-activated protein kinase inhibits glucocorticoid receptor function.
Wang X, Wu H, Miller AH
Mol Psychiatry. 2004
PubMed ID: 14699442
p38 MAP kinase-mediated negative inotropic effect of HIV gp120 on cardiac myocytes.
Kan H, Xie Z, Finkel MS
Am J Physiol Cell Physiol. 2004
PubMed ID: 14660488
Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury.
Tsuda M, Mizokoshi A, Shigemoto-Mogami Y, Koizumi S, Inoue K
Glia. 2004
PubMed ID: 14648549
Effects of p38MAPK isoforms on renal mesangial cell inducible nitric oxide synthase expression.
Lui P, Zeng C, Acton S, Cok S, Sexton A, Morrison AR
Am J Physiol Cell Physiol. 2004
PubMed ID: 14522818
ERK and p38 mediate high-glucose-induced hypertrophy and TGF-beta expression in renal tubular cells.
Fujita H, Omori S, Ishikura K, Hida M, Awazu M
Am J Physiol Renal Physiol. 2004
PubMed ID: 12952860
Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.
Piechotta K, Garbarini N, England R, Delpire E
J Biol Chem. 2003
PubMed ID: 14563843
Alterations in subcellular localization of p38 MAPK potentiates endothelin-stimulated COX-2 expression in glomerular mesangial cells.
Pratt PF, Bokemeyer D, Foschi M, Sorokin A, Dunn MJ
J Biol Chem. 2003
PubMed ID: 14530261
p38 mitogen-activated protein kinase modulates expression of tumor necrosis factor-related apoptosis-inducing ligand induced by interferon-gamma in fetal brain astrocytes.
Lee J, Shin JS, Park JY, Kwon D, Choi SJ, Kim SJ, Choi IH
J Neurosci Res. 2003
PubMed ID: 14648593
Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skin.
Kobayashi H, Aiba S, Yoshino Y, Tagami H
Exp Dermatol. 2003
PubMed ID: 14714552
Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis.
Stambe C, Atkins RC, Hill PA, Nikolic-Paterson DJ
Kidney Int. 2003
PubMed ID: 14633134
LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway.
Dobreva I, Waeber G, Mooser V, James RW, Widmann C
J Lipid Res. 2003
PubMed ID: 12951358
Acute p38 MAPK activation decreases force development in ventricular myocytes.
Chen Y, Rajashree R, Liu Q, Hofmann P
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12881212
Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival.
Zhang S, Ren J, Zhang CE, Treskov I, Wang Y, Muslin AJ
Circ Res. 2003
PubMed ID: 14593000
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Hyperosmolar mannitol simulates expression of aquaporins 4 and 9 through a p38 mitogen-activated protein kinase-dependent pathway in rat astrocytes.
Arima H, Yamamoto N, Sobue K, Umenishi F, Tada T, Katsuya H, Asai K
J Biol Chem. 2003
PubMed ID: 12944406
Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression.
Karsdal MA, Hjorth P, Henriksen K, Kirkegaard T, Nielsen KL, Lou H, Delaissé JM, Foged NT
J Biol Chem. 2003
PubMed ID: 12933809
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha.
Cheung PC, Campbell DG, Nebreda AR, Cohen P
EMBO J. 2003
PubMed ID: 14592977
Essential role for ERK2 mitogen-activated protein kinase in placental development.
Hatano N, Mori Y, Oh-hora M, Kosugi A, Fujikawa T, Nakai N, Niwa H, Miyazaki J, Hamaoka T, Ogata M
Genes Cells. 2003
PubMed ID: 14622137
Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation.
Guicheux J, Lemonnier J, Ghayor C, Suzuki A, Palmer G, Caverzasio J
J Bone Miner Res. 2003
PubMed ID: 14606520
Effect of NF-kappaB and p38 MAPK in activated monocytes/macrophages on pro-inflammatory cytokines of rats with acute pancreatitis.
Liu HS, Pan CE, Liu QG, Yang W, Liu XM
World J Gastroenterol. 2003
PubMed ID: 14606087
The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.
Lee TH, Huang Q, Oikemus S, Shank J, Ventura JJ, Cusson N, Vaillancourt RR, Su B, Davis RJ, Kelliher MA
Mol Cell Biol. 2003
PubMed ID: 14585994
p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages.
Li X, Udagawa N, Takami M, Sato N, Kobayashi Y, Takahashi N
Endocrinology. 2003
PubMed ID: 12960069
Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells.
Kirito K, Fox N, Kaushansky K
Blood. 2003
PubMed ID: 12855555
DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase.
Yuan L, Yu WM, Qu CK
J Biol Chem. 2003
PubMed ID: 12937170
A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.
Yellaturu CR, Rao GN
J Biol Chem. 2003
PubMed ID: 12928445
MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation.
Hoornaert I, Marynen P, Goris J, Sciot R, Baens M
Oncogene. 2003
PubMed ID: 14586399
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.
Trejo A, Arzeno H, Browner M, Chanda S, Cheng S, Comer DD, Dalrymple SA, Dunten P, Lafargue J, Lovejoy B, Freire-Moar J, Lim J, Mcintosh J, Miller J, Papp E, Reuter D, Roberts R, Sanpablo F, Saunders J, Song K, Villasenor A, Warren SD, Welch M, Weller P, Whiteley PE, Zeng L, Goldstein DM
J Med Chem. 2003
PubMed ID: 14561090
p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation.
Dean JL, Sarsfield SJ, Tsounakou E, Saklatvala J
J Biol Chem. 2003
PubMed ID: 12882963
P38 MAP kinase is activated at early stages in Alzheimer's disease brain.
Sun A, Liu M, Nguyen XV, Bing G
Exp Neurol. 2003
PubMed ID: 14552880
p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts.
Furukawa F, Matsuzaki K, Mori S, Tahashi Y, Yoshida K, Sugano Y, Yamagata H, Matsushita M, Seki T, Inagaki Y, Nishizawa M, Fujisawa J, Inoue K
Hepatology. 2003
PubMed ID: 14512875
p38 mitogen-activated protein kinase protects glomerular epithelial cells from complement-mediated cell injury.
Aoudjit L, Stanciu M, Li H, Lemay S, Takano T
Am J Physiol Renal Physiol. 2003
PubMed ID: 12837681
Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38.
Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ
Oncogene. 2003
PubMed ID: 13679851
TACE is required for fetal murine cardiac development and modeling.
Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG, Warburton D
Dev Biol. 2003
PubMed ID: 14499647
Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes.
Balasubramanian A, Ganju RK, Groopman JE
J Biol Chem. 2003
PubMed ID: 12824191
Role of p38 MAPK in lupeol-induced B16 2F2 mouse melanoma cell differentiation.
Hata K, Hori K, Takahashi S
J Biochem. 2003
PubMed ID: 14561730
Activation of phosphorylating-p38 mitogen-activated protein kinase and its relationship with localization of intestinal stem cells in rats after ischemia-reperfusion injury.
Fu XB, Xing F, Yang YH, Sun TZ, Guo BC
World J Gastroenterol. 2003
PubMed ID: 12970901
Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.
Goloudina A, Yamaguchi H, Chervyakova DB, Appella E, Fornace AJ, Bulavin DV
Cell Cycle. 2003
PubMed ID: 12963847
Inhibition of p38 mitogen-activated protein kinase interferes with cell shape changes and gene expression associated with Schwann cell myelination.
Fragoso G, Robertson J, Athlan E, Tam E, Almazan G, Mushynski WE
Exp Neurol. 2003
PubMed ID: 12957486
Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.
Fitzgerald CE, Patel SB, Becker JW, Cameron PM, Zaller D, Pikounis VB, O'Keefe SJ, Scapin G
Nat Struct Biol. 2003
PubMed ID: 12897767
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12897243
Mechanism of p38 MAP kinase activation in vivo.
Brancho D, Tanaka N, Jaeschke A, Ventura JJ, Kelkar N, Tanaka Y, Kyuuma M, Takeshita T, Flavell RA, Davis RJ
Genes Dev. 2003
PubMed ID: 12893778
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B
Nature. 2003
PubMed ID: 12872135
Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS
Circ Res. 2003
PubMed ID: 12829618
Oxidant-induced priming of the macrophage involves activation of p38 mitogen-activated protein kinase through an Src-dependent pathway.
Khadaroo RG, Parodo J, Powers KA, Papia G, Marshall JC, Kapus A, Rotstein OD
Surgery. 2003
PubMed ID: 12947324
The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG
Mol Cell Biol. 2003
PubMed ID: 12897141
Regulatory volume increase is associated with p38 kinase-dependent actin cytoskeleton remodeling in rat kidney MTAL.
Bustamante M, Roger F, Bochaton-Piallat ML, Gabbiani G, Martin PY, Feraille E
Am J Physiol Renal Physiol. 2003
PubMed ID: 12724128
TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism.
Yu Y, Zeng H, Lyons S, Carlson A, Merlin D, Neish AS, Gewirtz AT
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12702497
Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells.
Tfelt-Hansen J, MacLeod RJ, Chattopadhyay N, Yano S, Quinn S, Ren X, Terwilliger EF, Schwarz P, Brown EM
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12700162
Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.
Lynge J, Schulte G, Nordsborg N, Fredholm BB, Hellsten Y
Biochem Biophys Res Commun. 2003
PubMed ID: 12849998
Fibronectin blocks p38 and jnk activation by cyclic strain in Caco-2 cells.
Zhang J, Li W, Sumpio BE, Basson MD
Biochem Biophys Res Commun. 2003
PubMed ID: 12810082
Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.
Tan Y, Yu R, Pezzuto JM
Clin Cancer Res. 2003
PubMed ID: 12855667
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation.
Kim MJ, Park BJ, Kang YS, Kim HJ, Park JH, Kang JW, Lee SW, Han JM, Lee HW, Kim S
Nat Genet. 2003
PubMed ID: 12819782
Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.
Holgado-Madruga M, Wong AJ
Mol Cell Biol. 2003
PubMed ID: 12808090
Galectin-3 expression in macrophages is signaled by Ras/MAP kinase pathway and up-regulated by modified lipoproteins.
Kim K, Mayer EP, Nachtigal M
Biochim Biophys Acta. 2003
PubMed ID: 12788225
Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation.
Sharov AA, Weiner L, Sharova TY, Siebenhaar F, Atoyan R, Reginato AM, McNamara CA, Funa K, Gilchrest BA, Brissette JL, Botchkarev VA
EMBO J. 2003
PubMed ID: 12805214
Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma.
Iyoda K, Sasaki Y, Horimoto M, Toyama T, Yakushijin T, Sakakibara M, Takehara T, Fujimoto J, Hori M, Wands JR, Hayashi N
Cancer. 2003
PubMed ID: 12784337
p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades.
Sharma GD, He J, Bazan HE
J Biol Chem. 2003
PubMed ID: 12663671
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T
Nature. 2003
PubMed ID: 12802337
Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons.
Yamagishi S, Yamada M, Koshimizu H, Takai S, Hatanaka H, Takeda K, Ichijo H, Shimoke K, Ikeuchi T
J Biochem. 2003
PubMed ID: 12869527
Rapid mitogen-activated protein kinase by basic fibroblast growth factor in rat intestine after ischemia/reperfusion injury.
Fu XB, Yang YH, Sun TZ, Chen W, Li JY, Sheng ZY
World J Gastroenterol. 2003
PubMed ID: 12800247
Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes.
Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A
J Neurovirol. 2003
PubMed ID: 12775419
Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation.
Abraham E, Gyetko MR, Kuhn K, Arcaroli J, Strassheim D, Park JS, Shetty S, Idell S
J Immunol. 2003
PubMed ID: 12759445
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a.
Bulavin DV, Kovalsky O, Hollander MC, Fornace AJ
Mol Cell Biol. 2003
PubMed ID: 12748288
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R
Nat Immunol. 2003
PubMed ID: 12717433
Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor.
Choi KM, McMahon LP, Lawrence JC
J Biol Chem. 2003
PubMed ID: 12665511
The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.
Chen S, Nguyen N, Tamura K, Karin M, Tukey RH
J Biol Chem. 2003
PubMed ID: 12637498
Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus.
Kelly A, Vereker E, Nolan Y, Brady M, Barry C, Loscher CE, Mills KH, Lynch MA
J Biol Chem. 2003
PubMed ID: 12609991
Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis.
Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A
J Biol Chem. 2003
PubMed ID: 12637564
Lipopolysaccharide stimulates p38-dependent induction of antiviral genes in neutrophils independently of paracrine factors.
Malcolm KC, Worthen GS
J Biol Chem. 2003
PubMed ID: 12595530
Involvement of p38 MAPK and JNK in heat stress-induced cardioprotection.
Pantos C, Malliopoulou V, Mourouzis I, Moraitis P, Tzeis S, Thempeyioti A, Paizis I, Cokkinos A, Carageorgiou H, Varonos DD, Cokkinos DV
Basic Res Cardiol. 2003
PubMed ID: 12883833
Heat shock protein (HSP72) and p38 MAPK involvement in sublethal hemorrhage (SLH)-induced tolerance.
Carter Y, Liu G, Stephens WB, Carter G, Yang J, Mendez C
J Surg Res. 2003
PubMed ID: 12842450
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling.
Braz JC, Bueno OF, Liang Q, Wilkins BJ, Dai YS, Parsons S, Braunwart J, Glascock BJ, Klevitsky R, Kimball TF, Hewett TE, Molkentin JD
J Clin Invest. 2003
PubMed ID: 12750397
Role of p38 mitogen-activated protein kinase in lung injury after burn trauma.
Chen XL, Xia ZF, Ben DF, Wang GQ, Wei D
Shock. 2003
PubMed ID: 12744493
Effect of p38 mitogen-activated protein kinase on the replication of encephalomyocarditis virus.
Hirasawa K, Kim A, Han HS, Han J, Jun HS, Yoon JW
J Virol. 2003
PubMed ID: 12719557
p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels.
Sanz-Moreno V, Casar B, Crespo P
Mol Cell Biol. 2003
PubMed ID: 12697810
Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation.
Hu Y, Chan E, Wang SX, Li B
Endocrinology. 2003
PubMed ID: 12697715
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J
Nat Biotechnol. 2003
PubMed ID: 12665801
Transforming growth factor beta3 regulates the dynamics of Sertoli cell tight junctions via the p38 mitogen-activated protein kinase pathway.
Lui WY, Lee WM, Cheng CY
Biol Reprod. 2003
PubMed ID: 12606350
Doxorubicin and vinorelbine act independently via p53 expression and p38 activation respectively in breast cancer cell lines.
Liem AA, Appleyard MV, O'Neill MA, Hupp TR, Chamberlain MP, Thompson AM
Br J Cancer. 2003
PubMed ID: 12698197
CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response.
Awasthi A, Mathur R, Khan A, Joshi BN, Jain N, Sawant S, Boppana R, Mitra D, Saha B
J Exp Med. 2003
PubMed ID: 12695487
H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.
Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola M, Danni O
Exp Neurol. 2003
PubMed ID: 12684028
P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment.
Kaur J, Woodman RC, Kubes P
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12505871
Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model.
Zhu WH, Han J, Nicosia RF
J Vasc Res. 2003
PubMed ID: 12808350
High glucose activates the p38 MAPK pathway in cultured human peritoneal mesothelial cells.
Xu ZG, Kim KS, Park HC, Choi KH, Lee HY, Han DS, Kang SW
Kidney Int. 2003
PubMed ID: 12631076
Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway.
Wang JM, Lai MZ, Yang-Yen HF
Mol Cell Biol. 2003
PubMed ID: 12612065
Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.
Carlson CJ, Koterski S, Sciotti RJ, Poccard GB, Rondinone CM
Diabetes. 2003
PubMed ID: 12606502
Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.
Otsu K, Yamashita N, Nishida K, Hirotani S, Yamaguchi O, Watanabe T, Hikoso S, Higuchi Y, Matsumura Y, Maruyama M, Sudo T, Osada H, Hori M
Biochem Biophys Res Commun. 2003
PubMed ID: 12593847
Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.
Kang HJ, Soh Y, Kim MS, Lee EJ, Surh YJ, Kim HR, Kim SH, Moon A
Int J Cancer. 2003
PubMed ID: 12478662
Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.
Pikkarainen S, Tokola H, Kerkelä R, Majalahti-Palviainen T, Vuolteenaho O, Ruskoaho H
J Biol Chem. 2003
PubMed ID: 12446726
The binding of actin to p38 MAPK and inhibiting its kinase activity in vitro.
Yang K, Jiang Y, Han J, Gu J
Sci China C Life Sci. 2003
PubMed ID: 20213365
Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.
Takahashi M, Gotoh Y, Isagawa T, Nishimura T, Goyama E, Kim HS, Mukai H, Ono Y
J Biochem. 2003
PubMed ID: 12761180
Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis.
Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, Nokubi T, Yoneda T
Mol Biol Cell. 2003
PubMed ID: 12589053
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landström M
Mol Biol Cell. 2003
PubMed ID: 12589052
Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway.
Iwasa H, Han J, Ishikawa F
Genes Cells. 2003
PubMed ID: 12581156
Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis.
Stambe C, Atkins RC, Tesch GH, Kapoun AM, Hill PA, Schreiner GF, Nikolic-Paterson DJ
J Am Soc Nephrol. 2003
PubMed ID: 12538734
Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development.
Hsu SC, Wu CC, Han J, Lai MZ
Blood. 2003
PubMed ID: 12393706
TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1.
Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J
J Biol Chem. 2003
PubMed ID: 12429732
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Stelmach JE, Liu L, Patel SB, Pivnichny JV, Scapin G, Singh S, Hop CE, Wang Z, Strauss JR, Cameron PM, Nichols EA, O'Keefe SJ, O'Neill EA, Schmatz DM, Schwartz CD, Thompson CM, Zaller DM, Doherty JB
Bioorg Med Chem Lett. 2003
PubMed ID: 12482439
Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.
Wu D, Cederbaum AI
J Biol Chem. 2003
PubMed ID: 12403788
Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.
Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ
J Biol Chem. 2003
PubMed ID: 12399465
Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.
Teruel T, Hernandez R, Benito M, Lorenzo M
J Biol Chem. 2003
PubMed ID: 12414803
Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase-A and p38 MAPK.
Parameswaran N, Hall CS, McCabe LR, Spielman WS
Cell Physiol Biochem. 2003
PubMed ID: 14631143
Renal abnormalities in mice caused by insufficiency of p38alpha.
Maruyama M, Yagasaki Y, Sudo T, Osada H
J Recept Signal Transduct Res. 2003
PubMed ID: 14626445
Hypertonicity promotes survival of corticospinal motoneurons via mitogen-activated protein kinase p38 signaling.
Junger H, Edelman DB, Junger WG
J Mol Neurosci. 2003
PubMed ID: 14593211
Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: requirement for sustained ERK activation.
Thoresen GH, Guren TK, Christoffersen T
Cell Physiol Biochem. 2003
PubMed ID: 12876381
p38 MAPK interacts with actin and modulates filament assembly during skeletal muscle differentiation.
Khurana A, Dey CS
Differentiation. 2003
PubMed ID: 12558602
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts.
Frevel MA, Bakheet T, Silva AM, Hissong JG, Khabar KS, Williams BR
Mol Cell Biol. 2003
PubMed ID: 12509443
p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice.
Iwata Y, Wada T, Furuichi K, Sakai N, Matsushima K, Yokoyama H, Kobayashi K
J Am Soc Nephrol. 2003
PubMed ID: 12506138
Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.
Ambrosino C, Mace G, Galban S, Fritsch C, Vintersten K, Black E, Gorospe M, Nebreda AR
Mol Cell Biol. 2003
PubMed ID: 12482988
A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation.
Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, Trevillyan J, Scherer PE, Rondinone CM, Klip A
J Biol Chem. 2002
PubMed ID: 12393894
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1).
Piechotta K, Lu J, Delpire E
J Biol Chem. 2002
PubMed ID: 12386165
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.
Lim S, Zou Y, Friedman E
J Biol Chem. 2002
PubMed ID: 12384504
Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2.
Katz S, Aronheim A
Biochem J. 2002
PubMed ID: 12225289
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.
Wang L, Ma R, Flavell RA, Choi ME
J Biol Chem. 2002
PubMed ID: 12374793
Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A.
D'Addario M, Arora PD, Ellen RP, McCulloch CA
J Biol Chem. 2002
PubMed ID: 12324467
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Changes in expression of p38 mitogen-activated protein kinase in the dorsal motor nucleus of the vagus nerve and hypoglossal nucleus after axotomy in adult rats.
Shimokawara T, Yamada E, Masui K, Mishima K, Enomoto Y, Inoue K, Sakaki T, Ichijima K
Neuropathology. 2002
PubMed ID: 12564765
Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.
Kondoh M, Tasaki E, Araragi S, Takiguchi M, Higashimoto M, Watanabe Y, Sato M
Eur J Biochem. 2002
PubMed ID: 12473116
Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).
Ko BC, Lam AK, Kapus A, Fan L, Chung SK, Chung SS
J Biol Chem. 2002
PubMed ID: 12359721
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Garner AP, Weston CR, Todd DE, Balmanno K, Cook SJ
Oncogene. 2002
PubMed ID: 12444545
In vivo role of p38 mitogen-activated protein kinase in mediating the anti-inflammatory effects of CpG oligodeoxynucleotide in murine asthma.
Choudhury BK, Wild JS, Alam R, Klinman DM, Boldogh I, Dharajiya N, Mileski WJ, Sur S
J Immunol. 2002
PubMed ID: 12421981
Activation of p38 MAPK induces cell cycle arrest via inhibition of Raf/ERK pathway during muscle differentiation.
Lee J, Hong F, Kwon S, Kim SS, Kim DO, Kang HS, Lee SJ, Ha J, Kim SS
Biochem Biophys Res Commun. 2002
PubMed ID: 12419320
Involvement of intracellular Ca2+ elevation but not cyclic AMP in PACAP-induced p38 MAP kinase activation in PC12 cells.
Sakai Y, Hashimoto H, Shintani N, Ichibori A, Tomimoto S, Tanaka K, Hirose M, Baba A
Regul Pept. 2002
PubMed ID: 12409227
Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways.
Dohi K, Mizushima H, Nakajo S, Ohtaki H, Matsunaga S, Aruga T, Shioda S
Regul Pept. 2002
PubMed ID: 12409219
Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase.
Nick JA, Young SK, Arndt PG, Lieber JG, Suratt BT, Poch KR, Avdi NJ, Malcolm KC, Taube C, Henson PM, Worthen GS
J Immunol. 2002
PubMed ID: 12391245
Hypoxia induces nitric oxide production in mouse microglia via p38 mitogen-activated protein kinase pathway.
Park SY, Lee H, Hur J, Kim SY, Kim H, Park JH, Cha S, Kang SS, Cho GJ, Choi WS, Suk K
Brain Res Mol Brain Res. 2002
PubMed ID: 12414118
JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.
Lee CM, Onésime D, Reddy CD, Dhanasekaran N, Reddy EP
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12391307
Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein.
Lee KS, Hong SH, Bae SC
Oncogene. 2002
PubMed ID: 12370805
Innate recognition of bacteria by a macrophage cytosolic surveillance pathway.
O'Riordan M, Yi CH, Gonzales R, Lee KD, Portnoy DA
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12359878
Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
Knebel A, Haydon CE, Morrice N, Cohen P
Biochem J. 2002
PubMed ID: 12171600
The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line, HaCaT.
Bachelor MA, Silvers AL, Bowden GT
Oncogene. 2002
PubMed ID: 12370831
P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose.
Zayzafoon M, Botolin S, McCabe LR
J Biol Chem. 2002
PubMed ID: 12149242
Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity.
Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y
J Biol Chem. 2002
PubMed ID: 12138127
In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.
Shi Y, Gaestel M
Biol Chem. 2002
PubMed ID: 12452429
Involvement of Rho and p38 MAPK in endothelin-1-induced expression of PGHS-2 mRNA in osteoblast-like cells.
Windischhofer W, Zach D, Fauler G, Raspotnig G, Köfeler H, Leis HJ
J Bone Miner Res. 2002
PubMed ID: 12369781
Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways.
Masuda A, Yoshikai Y, Aiba K, Matsuguchi T
J Immunol. 2002
PubMed ID: 12244175
Both binding and activation of p38 mitogen-activated protein kinase (MAPK) play essential roles in regulation of the nucleocytoplasmic distribution of MAPK-activated protein kinase 5 by cellular stress.
Seternes OM, Johansen B, Hegge B, Johannessen M, Keyse SM, Moens U
Mol Cell Biol. 2002
PubMed ID: 12242275
gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.
Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman FD, Taylor N
Blood. 2002
PubMed ID: 12239168
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation.
Ramsauer K, Sadzak I, Porras A, Pilz A, Nebreda AR, Decker T, Kovarik P
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12232043
Evidence for the role of p38 MAP kinase in hypoxia-induced pulmonary vasoconstriction.
Karamsetty MR, Klinger JR, Hill NS
Am J Physiol Lung Cell Mol Physiol. 2002
PubMed ID: 12225963
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo.
Hirai S, Kawaguchi A, Hirasawa R, Baba M, Ohnishi T, Ohno S
Development. 2002
PubMed ID: 12223406
p38 MAPK mediates the regulation of alpha1(I) procollagen mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells(1).
Varela-Rey M, Montiel-Duarte C, Osés-Prieto JA, López-Zabalza MJ, Jaffrèzou JP, Rojkind M, Iraburu MJ
FEBS Lett. 2002
PubMed ID: 12297293
Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.
Park JM, Greten FR, Li ZW, Karin M
Science. 2002
PubMed ID: 12202685
Apoptotic changes in the aged brain are triggered by interleukin-1beta-induced activation of p38 and reversed by treatment with eicosapentaenoic acid.
Martin DS, Lonergan PE, Boland B, Fogarty MP, Brady M, Horrobin DF, Campbell VA, Lynch MA
J Biol Chem. 2002
PubMed ID: 12091394
Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.
Lejeune D, Dumoutier L, Constantinescu S, Kruijer W, Schuringa JJ, Renauld JC
J Biol Chem. 2002
PubMed ID: 12087100
P38 mitogen-activated protein kinase influence on the production of IL-10 in human schistosomiasis mansoni.
Carneiro-Santos P, Alves-Oliveira LF, Correa-Oliveira R, Hagan P
Parasite Immunol. 2002
PubMed ID: 12654092
The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid.
Hsieh CC, Papaconstantinou J
Mech Ageing Dev. 2002
PubMed ID: 12425949
Nitric oxide interferes with salivary mucin synthesis: involvement of ERK and p38 mitogen-activated protein kinase.
Slomiany BL, Slomiany A
J Physiol Pharmacol. 2002
PubMed ID: 12369731
Subtype specific roles of mitogen activated protein kinases in L6E9 skeletal muscle cell differentiation.
Khurana A, Dey CS
Mol Cell Biochem. 2002
PubMed ID: 12349907
Thrombin stimulates dissociation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells.
Hirade K, Kozawa O, Tanabe K, Niwa M, Matsuno H, Oiso Y, Akamatsu S, Ito H, Kato K, Katagiri Y, Uematsu T
Am J Physiol Heart Circ Physiol. 2002
PubMed ID: 12181122
Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells.
Blaschke F, Stawowy P, Goetze S, Hintz O, Gräfe M, Kintscher U, Fleck E, Graf K
Biochem Biophys Res Commun. 2002
PubMed ID: 12200131
Glutathione oxidation in calcium- and p38 MAPK-dependent membrane blebbing of endothelial cells.
van Gorp RM, Heeneman S, Broers JL, Bronnenberg NM, van Dam-Mieras MC, Heemskerk JW
Biochim Biophys Acta. 2002
PubMed ID: 12183063
Mercury inhibits nitric oxide production but activates proinflammatory cytokine expression in murine macrophage: differential modulation of NF-kappaB and p38 MAPK signaling pathways.
Kim SH, Johnson VJ, Sharma RP
Nitric Oxide. 2002
PubMed ID: 12175822
The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway.
Uchi H, Arrighi JF, Aubry JP, Furue M, Hauser C
J Allergy Clin Immunol. 2002
PubMed ID: 12170268
Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation.
Lee H, Bai W
Mol Cell Biol. 2002
PubMed ID: 12138194
Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase.
Markou T, Lazou A
Biochem J. 2002
PubMed ID: 11994045
Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase.
Shim MJ, Kim HJ, Yang SJ, Lee IS, Choi HI, Kim T
J Biochem Mol Biol. 2002
PubMed ID: 12296996
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
Ouwens DM, de Ruiter ND, van der Zon GC, Carter AP, Schouten J, van der Burgt C, Kooistra K, Bos JL, Maassen JA, van Dam H
EMBO J. 2002
PubMed ID: 12110590
p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.
Korus M, Mahon GM, Cheng L, Whitehead IP
Oncogene. 2002
PubMed ID: 12096337
HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication.
Cicala C, Arthos J, Selig SM, Dennis G, Hosack DA, Van Ryk D, Spangler ML, Steenbeke TD, Khazanie P, Gupta N, Yang J, Daucher M, Lempicki RA, Fauci AS
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12089333
Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells.
Chung J, Bachelder RE, Lipscomb EA, Shaw LM, Mercurio AM
J Cell Biol. 2002
PubMed ID: 12105188
Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells.
Neve RM, Holbro T, Hynes NE
Oncogene. 2002
PubMed ID: 12085235
Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers.
Brand P, Plochmann S, Valk E, Zahn S, Saloga J, Knop J, Becker D
J Invest Dermatol. 2002
PubMed ID: 12164931
Hepatic ischemic preconditioning in mice is associated with activation of NF-kappaB, p38 kinase, and cell cycle entry.
Teoh N, Dela Pena A, Farrell G
Hepatology. 2002
PubMed ID: 12085353
UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53.
Chouinard N, Valerie K, Rouabhia M, Huot J
Biochem J. 2002
PubMed ID: 12071847
Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.
Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L
Nat Genet. 2002
PubMed ID: 12068299
Rac GTPase activity is essential for lipopolysaccharide signaling to extracellular signal-regulated kinase and p38 MAP kinase activation in rat-2 fibroblasts.
Woo CH, Kim JH
Mol Cells. 2002
PubMed ID: 12132588
p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons.
Zhu Y, Mao XO, Sun Y, Xia Z, Greenberg DA
J Biol Chem. 2002
PubMed ID: 11948180
Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity.
Anguita J, Barthold SW, Persinski R, Hedrick MN, Huy CA, Davis RJ, Flavell RA, Fikrig E
J Immunol. 2002
PubMed ID: 12055252
ATF-1 mediates protease-activated receptor-1 but not receptor tyrosine kinase-induced DNA synthesis in vascular smooth muscle cells.
Ghosh SK, Gadiparthi L, Zeng ZZ, Bhanoori M, Tellez C, Bar-Eli M, Rao GN
J Biol Chem. 2002
PubMed ID: 11925444
p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: implications for its physiological significance.
Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG, Kim S
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12060739
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b.
Chang CI, Xu BE, Akella R, Cobb MH, Goldsmith EJ
Mol Cell. 2002
PubMed ID: 12086621
Activation of p38 mitogen-activated protein kinase and nuclear factor-kappaB in tumour necrosis factor-induced eotaxin release of human eosinophils.
Wong CK, Zhang JP, Ip WK, Lam CW
Clin Exp Immunol. 2002
PubMed ID: 12067303
p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression.
Xu Q, Yu L, Liu L, Cheung CF, Li X, Yee SP, Yang XJ, Wu Z
Mol Biol Cell. 2002
PubMed ID: 12058061
Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells.
Banerjee S, Narayanan K, Mizutani T, Makino S
J Virol. 2002
PubMed ID: 12021326
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Yang TT, Xiong Q, Enslen H, Davis RJ, Chow CW
Mol Cell Biol. 2002
PubMed ID: 11997522
Insulin restores differentiation of Ras-transformed C2C12 myoblasts by inducing NF-kappaB through an AKT/P70S6K/p38-MAPK pathway.
Conejo R, de Alvaro C, Benito M, Cuadrado A, Lorenzo M
Oncogene. 2002
PubMed ID: 12032842
Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells.
Jung YD, Fan F, McConkey DJ, Jean ME, Liu W, Reinmuth N, Stoeltzing O, Ahmad SA, Parikh AA, Mukaida N, Ellis LM
Cytokine. 2002
PubMed ID: 12126643
Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis.
Brouard S, Berberat PO, Tobiasch E, Seldon MP, Bach FH, Soares MP
J Biol Chem. 2002
PubMed ID: 11880364
p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease.
Waetzig GH, Seegert D, Rosenstiel P, Nikolaus S, Schreiber S
J Immunol. 2002
PubMed ID: 11994493
Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase.
Dickinson RJ, Williams DJ, Slack DN, Williamson J, Seternes OM, Keyse SM
Biochem J. 2002
PubMed ID: 11988087
BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.
Hemmeryckx B, Reichert A, Watanabe M, Kaartinen V, de Jong R, Pattengale PK, Groffen J, Heisterkamp N
Oncogene. 2002
PubMed ID: 12082638
Gö6976 protects mesencephalic neurons from lipopolysaccharide-elicited death by inhibiting p38 MAP kinase phosphorylation.
Jeohn GH, Cooper CL, Jang KJ, Kim HC, Hong JS
Ann N Y Acad Sci. 2002
PubMed ID: 12076986
p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures.
Jeohn GH, Cooper CL, Wilson B, Chang RC, Jang KJ, Kim HC, Liu B, Hong JS
Ann N Y Acad Sci. 2002
PubMed ID: 12076985
Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
Sordella R, Classon M, Hu KQ, Matheson SF, Brouns MR, Fine B, Zhang L, Takami H, Yamada Y, Settleman J
Dev Cell. 2002
PubMed ID: 12015964
Phospholipase C-beta 2 interacts with mitogen-activated protein kinase kinase 3.
Barr AJ, Marjoram R, Xu J, Snyderman R
Biochem Biophys Res Commun. 2002
PubMed ID: 12054652
Involvement of p38 and JNK MAPKs pathways in Substance P-induced production of TNF-alpha by peritoneal mast cells.
Azzolina A, Guarneri P, Lampiasi N
Cytokine. 2002
PubMed ID: 12096921
Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.
Kerkelä R, Pikkarainen S, Majalahti-Palviainen T, Tokola H, Ruskoaho H
J Biol Chem. 2002
PubMed ID: 11827958
Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis.
Singhal PC, Bhaskaran M, Patel J, Patel K, Kasinath BS, Duraisamy S, Franki N, Reddy K, Kapasi AA
J Immunol. 2002
PubMed ID: 11937560
Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C.
Li B, Ishii T, Tan CP, Soh JW, Goff SP
J Biol Chem. 2002
PubMed ID: 11796722
Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase.
Dermitzaki E, Tsatsanis C, Gravanis A, Margioris AN
J Biol Chem. 2002
PubMed ID: 11790788
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.
Liacini A, Sylvester J, Li WQ, Zafarullah M
Matrix Biol. 2002
PubMed ID: 12009331
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS
Mol Cell Biol. 2002
PubMed ID: 11909979
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
Pargellis C, Tong L, Churchill L, Cirillo PF, Gilmore T, Graham AG, Grob PM, Hickey ER, Moss N, Pav S, Regan J
Nat Struct Biol. 2002
PubMed ID: 11896401
Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin.
Shields JM, Mehta H, Pruitt K, Der CJ
Mol Cell Biol. 2002
PubMed ID: 11884615
The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells.
Min DS, Shin EY, Kim EG
Exp Mol Med. 2002
PubMed ID: 11989977
Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling.
Mansky KC, Sankar U, Han J, Ostrowski MC
J Biol Chem. 2002
PubMed ID: 11792706
Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation.
Ku NO, Azhar S, Omary MB
J Biol Chem. 2002
PubMed ID: 11788583
The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.
He T, Stepulak A, Holmström TH, Omary MB, Eriksson JE
J Biol Chem. 2002
PubMed ID: 11781324
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.
Maher P
Oncogene. 2002
PubMed ID: 11960370
Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation.
Liu G, Zhang Y, Bode AM, Ma WY, Dong Z
J Biol Chem. 2002
PubMed ID: 11777913
Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection.
Baines CP, Zhang J, Wang GW, Zheng YT, Xiu JX, Cardwell EM, Bolli R, Ping P
Circ Res. 2002
PubMed ID: 11884367
Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.
Sudo T, Yagasaki Y, Hama H, Watanabe N, Osada H
Biochem Biophys Res Commun. 2002
PubMed ID: 11866441
Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis.
Verma A, Deb DK, Sassano A, Uddin S, Varga J, Wickrema A, Platanias LC
J Biol Chem. 2002
PubMed ID: 11773065
Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation.
Laprise P, Chailler P, Houde M, Beaulieu JF, Boucher MJ, Rivard N
J Biol Chem. 2002
PubMed ID: 11756422
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.
McDermott EP, O'Neill LA
J Biol Chem. 2002
PubMed ID: 11744690
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J
Science. 2002
PubMed ID: 11847341
The involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein (MAP) kinase in TRAIL/Apo2L-induced apoptosis.
Lee MW, Park SC, Yang YG, Yim SO, Chae HS, Bach JH, Lee HJ, Kim KY, Lee WB, Kim SS
FEBS Lett. 2002
PubMed ID: 11852102
p38 MAP kinase mediates the cell death induced by PrP106-126 in the SH-SY5Y neuroblastoma cells.
Thellung S, Villa V, Corsaro A, Arena S, Millo E, Damonte G, Benatti U, Tagliavini F, Florio T, Schettini G
Neurobiol Dis. 2002
PubMed ID: 11848686
Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.
Tárrega C, Blanco-Aparicio C, Muñoz JJ, Pulido R
J Biol Chem. 2002
PubMed ID: 11711538
Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase.
Dmitrieva NI, Bulavin DV, Fornace AJ, Burg MB
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11756692
Down-regulated circulating PMN function after injury despite enhanced p38 MAPK activity.
Sheth K, Friel J, Nolan B, Miller-Graziano C, Bankey P
Surg Infect (Larchmt). 2002
PubMed ID: 12519482
Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line.
Hall JP, Davis RJ
J Cell Biochem. 2002
PubMed ID: 12112010
Specificity of arachidonic acid-induced inhibition of growth and activation of c-jun kinases and p38 mitogen-activated protein kinase in hematopoietic cells.
Rizzo MT, Pudlo N, Farrell L, Leaver A
Prostaglandins Leukot Essent Fatty Acids. 2002
PubMed ID: 12051955
Evidence for a role of p38 MAP kinase in expression of alkaline phosphatase during osteoblastic cell differentiation.
Suzuki A, Guicheux J, Palmer G, Miura Y, Oiso Y, Bonjour JP, Caverzasio J
Bone. 2002
PubMed ID: 11792570
The phosphatidylinositol 3-kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation.
Lee SE, Woo KM, Kim SY, Kim HM, Kwack K, Lee ZH, Kim HH
Bone. 2002
PubMed ID: 11792567
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.
Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W
J Biol Chem. 2001
PubMed ID: 11551930
HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling.
Del Corno M, Liu QH, Schols D, de Clercq E, Gessani S, Freedman BD, Collman RG
Blood. 2001
PubMed ID: 11698270
Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2.
Janknecht R
J Biol Chem. 2001
PubMed ID: 11551945
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway.
Bi R, Foy MR, Vouimba RM, Thompson RF, Baudry M
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11687663
Human endotoxemia activates p38 MAP kinase and p42/44 MAP kinase, but not c-Jun N-terminal kinase.
van den Blink B, Branger J, Weijer S, Deventer SH, van der Poll T, Peppelenbosch MP
Mol Med. 2001
PubMed ID: 11788789
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.
Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM
Mol Cell. 2001
PubMed ID: 11741533
Hierarchical phosphorylation of the translation inhibitor 4E-BP1.
Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N
Genes Dev. 2001
PubMed ID: 11691836
Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.
Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK
Mol Cell Biol. 2001
PubMed ID: 11604491
Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release.
Torcia M, De Chiara G, Nencioni L, Ammendola S, Labardi D, Lucibello M, Rosini P, Marlier LN, Bonini P, Dello Sbarba P, Palamara AT, Zambrano N, Russo T, Garaci E, Cozzolino F
J Biol Chem. 2001
PubMed ID: 11495898
MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein.
Masuda K, Shima H, Watanabe M, Kikuchi K
J Biol Chem. 2001
PubMed ID: 11489891
The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.
Katz S, Heinrich R, Aronheim A
FEBS Lett. 2001
PubMed ID: 11602244
The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.
Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11593045
Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase.
Hjälm G, MacLeod RJ, Kifor O, Chattopadhyay N, Brown EM
J Biol Chem. 2001
PubMed ID: 11390380
Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase.
Ishizuka T, Okajima F, Ishiwara M, Iizuka K, Ichimonji I, Kawata T, Tsukagoshi H, Dobashi K, Nakazawa T, Mori M
J Immunol. 2001
PubMed ID: 11490018
Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.
Chen P, Hutter D, Yang X, Gorospe M, Davis RJ, Liu Y
J Biol Chem. 2001
PubMed ID: 11387337
HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway.
Missé D, Esteve PO, Renneboog B, Vidal M, Cerutti M, St Pierre Y, Yssel H, Parmentier M, Veas F
Blood. 2001
PubMed ID: 11468147
Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase.
Hundley TR, Prasad AR, Beaven MA
J Immunol. 2001
PubMed ID: 11466386
Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain.
Aoyama K, Nagata M, Oshima K, Matsuda T, Aoki N
J Biol Chem. 2001
PubMed ID: 11346645
A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.
Tanoue T, Yamamoto T, Maeda R, Nishida E
J Biol Chem. 2001
PubMed ID: 11359773
Phosphorylation of MafA is essential for its transcriptional and biological properties.
Benkhelifa S, Provot S, Nabais E, Eychène A, Calothy G, Felder-Schmittbuhl MP
Mol Cell Biol. 2001
PubMed ID: 11416124
Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation.
Zhang Y, Dong Z, Nomura M, Zhong S, Chen N, Bode AM, Dong Z
J Biol Chem. 2001
PubMed ID: 11279232
Rac and p38 kinase mediate 5-lipoxygenase translocation and cell death.
Eom YW, Cho SH, Hwang JS, Yoon SB, Na DS, Kang IJ, Kang SS, Song WK, Kim JH
Biochem Biophys Res Commun. 2001
PubMed ID: 11374881
Pro-apoptotic gene expression mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
De Zutter GS, Davis RJ
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11344273
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.
Chen Z, Cobb MH
J Biol Chem. 2001
PubMed ID: 11279118
Calcineurin enhances MAPK phosphatase-1 expression and p38 MAPK inactivation in cardiac myocytes.
Lim HW, New L, Han J, Molkentin JD
J Biol Chem. 2001
PubMed ID: 11279073
Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.
Slack DN, Seternes OM, Gabrielsen M, Keyse SM
J Biol Chem. 2001
PubMed ID: 11278799
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.
Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ
Nature. 2001
PubMed ID: 11333986
p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression.
Westermarck J, Li SP, Kallunki T, Han J, Kähäri VM
Mol Cell Biol. 2001
PubMed ID: 11259586
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.
Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR
J Biol Chem. 2001
PubMed ID: 11042204
Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.
Tanoue T, Maeda R, Adachi M, Nishida E
EMBO J. 2001
PubMed ID: 11157753
The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
Scheper GC, Morrice NA, Kleijn M, Proud CG
Mol Cell Biol. 2001
PubMed ID: 11154262
Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression.
Kovarik P, Mangold M, Ramsauer K, Heidari H, Steinborn R, Zotter A, Levy DE, Müller M, Decker T
EMBO J. 2001
PubMed ID: 11226159
Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC
Annu Rev Neurosci. 2001
PubMed ID: 11520933
Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength.
Alonso G, Ambrosino C, Jones M, Nebreda AR
J Biol Chem. 2000
PubMed ID: 11010976
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
Hefner Y, Borsch-Haubold AG, Murakami M, Wilde JI, Pasquet S, Schieltz D, Ghomashchi F, Yates JR, Armstrong CG, Paterson A, Cohen P, Fukunaga R, Hunter T, Kudo I, Watson SP, Gelb MH
J Biol Chem. 2000
PubMed ID: 10978317
Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.
Hutter D, Chen P, Barnes J, Liu Y
Biochem J. 2000
PubMed ID: 11062068
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies.
Mothe-Satney I, Brunn GJ, McMahon LP, Capaldo CT, Abraham RT, Lawrence JC
J Biol Chem. 2000
PubMed ID: 10942774
The ternary complex factor Net contains two distinct elements that mediate different responses to MAP kinase signalling cascades.
Ducret C, Maira SM, Lutz Y, Wasylyk B
Oncogene. 2000
PubMed ID: 11042694
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis.
Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10973481
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.
Visconti R, Gadina M, Chiariello M, Chen EH, Stancato LF, Gutkind JS, O'Shea JJ
Blood. 2000
PubMed ID: 10961885
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.
Goh KC, deVeer MJ, Williams BR
EMBO J. 2000
PubMed ID: 10944112
Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.
Tomás-Zuber M, Mary JL, Lesslauer W
J Biol Chem. 2000
PubMed ID: 10806207
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M
Cell. 2000
PubMed ID: 10943842
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
Luciani MG, Hutchins JR, Zheleva D, Hupp TR
J Mol Biol. 2000
PubMed ID: 10884347
Activation of mitogen-activated protein kinases is required for alpha1-adrenergic agonist-induced cell scattering in transfected HepG2 cells.
Spector M, Nguyen VA, Sheng X, He L, Woodward J, Fan S, Baumgarten CM, Kunos G, Dent P, Gao B
Exp Cell Res. 2000
PubMed ID: 10912793
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development.
Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR
Mol Cell. 2000
PubMed ID: 10949032
Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Lee K, Deng X, Friedman E
Cancer Res. 2000
PubMed ID: 10910078
p38 MAPK signalling cascades: ancient roles and new functions.
Martín-Blanco E
Bioessays. 2000
PubMed ID: 10878576
Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.
Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD
J Biol Chem. 2000
PubMed ID: 10849446
Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2.
Sanz V, Arozarena I, Crespo P
FEBS Lett. 2000
PubMed ID: 10838079
Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.
Sayed M, Kim SO, Salh BS, Issinger OG, Pelech SL
J Biol Chem. 2000
PubMed ID: 10747897
Serum-induced monocyte differentiation and monocyte chemotaxis are regulated by the p38 MAP kinase signal transduction pathway.
Ayala JM, Goyal S, Liverton NJ, Claremon DA, O'Keefe SJ, Hanlon WA
J Leukoc Biol. 2000
PubMed ID: 10857861
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps.
Wu Z, Woodring PJ, Bhakta KS, Tamura K, Wen F, Feramisco JR, Karin M, Wang JY, Puri PL
Mol Cell Biol. 2000
PubMed ID: 10805738
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway.
Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ
Science. 2000
PubMed ID: 10797012
Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression.
Mothe-Satney I, Yang D, Fadden P, Haystead TA, Lawrence JC
Mol Cell Biol. 2000
PubMed ID: 10779345
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases.
Kampen GT, Stafford S, Adachi T, Jinquan T, Quan S, Grant JA, Skov PS, Poulsen LK, Alam R
Blood. 2000
PubMed ID: 10706854
Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells.
Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA
J Exp Med. 2000
PubMed ID: 10704466
Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells.
Merritt C, Enslen H, Diehl N, Conze D, Davis RJ, Rincón M
Mol Cell Biol. 2000
PubMed ID: 10629051
Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.
Faccio L, Fusco C, Chen A, Martinotti S, Bonventre JV, Zervos AS
J Biol Chem. 2000
PubMed ID: 10644717
Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo.
Diehl NL, Enslen H, Fortner KA, Merritt C, Stetson N, Charland C, Flavell RA, Davis RJ, Rincón M
J Exp Med. 2000
PubMed ID: 10637276
Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
Shewchuk L, Hassell A, Wisely B, Rocque W, Holmes W, Veal J, Kuyper LF
J Med Chem. 2000
PubMed ID: 10633045
A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase.
Blanco-Aparicio C, Torres J, Pulido R
J Cell Biol. 1999
PubMed ID: 10601328
Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.
Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ
EMBO J. 1999
PubMed ID: 10581258
MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases.
Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A
Oncogene. 1999
PubMed ID: 10597297
The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.
Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W
Oncogene. 1999
PubMed ID: 10557092
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase.
Saxena M, Williams S, Taskén K, Mustelin T
Nat Cell Biol. 1999
PubMed ID: 10559944
Direct suppression of TCR-mediated activation of extracellular signal-regulated kinase by leukocyte protein tyrosine phosphatase, a tyrosine-specific phosphatase.
Oh-hora M, Ogata M, Mori Y, Adachi M, Imai K, Kosugi A, Hamaoka T
J Immunol. 1999
PubMed ID: 10415025
Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
Tanoue T, Moriguchi T, Nishida E
J Biol Chem. 1999
PubMed ID: 10391943
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N
Genes Dev. 1999
PubMed ID: 10364159
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.
Yang SH, Galanis A, Sharrocks AD
Mol Cell Biol. 1999
PubMed ID: 10330143
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M
Genes Dev. 1999
PubMed ID: 10346818
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.
Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE
Oncogene. 1999
PubMed ID: 10348343
Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP).
Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T
J Biol Chem. 1999
PubMed ID: 10206983
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling.
Sano Y, Harada J, Tashiro S, Gotoh-Mandeville R, Maekawa T, Ishii S
J Biol Chem. 1999
PubMed ID: 10085140
Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.
Hu MC, Wang YP, Mikhail A, Qiu WR, Tan TH
J Biol Chem. 1999
PubMed ID: 10066767
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation.
Li B, Tournier C, Davis RJ, Flavell RA
EMBO J. 1999
PubMed ID: 9889198
Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein.
Quevillon S, Robinson JC, Berthonneau E, Siatecka M, Mirande M
J Mol Biol. 1999
PubMed ID: 9878398
Regulation of the MEF2 family of transcription factors by p38.
Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J
Mol Cell Biol. 1999
PubMed ID: 9858528
Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.
Herbison CE, Sayer DC, Bellgard M, Allcock RJ, Christiansen FT, Price P
DNA Seq. 1999
PubMed ID: 10727080
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
Pierrat B, Correia JS, Mary JL, Tomás-Zuber M, Lesslauer W
J Biol Chem. 1998
PubMed ID: 9792677
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.
Xia Y, Wu Z, Su B, Murray B, Karin M
Genes Dev. 1998
PubMed ID: 9808624
Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases.
Dowd S, Sneddon AA, Keyse SM
J Cell Sci. 1998
PubMed ID: 9788880
Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart.
Kim SO, Irwin P, Katz S, Pelech SL
J Cell Biochem. 1998
PubMed ID: 9779826
Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.
Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA
Nucleic Acids Res. 1998
PubMed ID: 9753748
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.
Sugawara T, Moriguchi T, Nishida E, Takahama Y
Immunity. 1998
PubMed ID: 9806642
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2.
Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ
Curr Biol. 1998
PubMed ID: 9768359
Structural basis of inhibitor selectivity in MAP kinases.
Wang Z, Canagarajah BJ, Boehm JC, Kassisà S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ
Structure. 1998
PubMed ID: 9753691
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
Deak M, Clifton AD, Lucocq LM, Alessi DR
EMBO J. 1998
PubMed ID: 9687510
PRAK, a novel protein kinase regulated by the p38 MAP kinase.
New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GC, Han J
EMBO J. 1998
PubMed ID: 9628874
Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest.
Takenaka K, Moriguchi T, Nishida E
Science. 1998
PubMed ID: 9554853
Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.
Börsch-Haubold AG, Bartoli F, Asselin J, Dudler T, Kramer RM, Apitz-Castro R, Watson SP, Gelb MH
J Biol Chem. 1998
PubMed ID: 9468497
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9465032
Suppression subtractive hybridization (SSH) identifies prolactin stimulation of p38 MAP kinase gene expression in Nb2 T lymphoma cells: molecular cloning of rat p38 MAP kinase.
Nemeth E, Bole-Feysot C, Tashima LS
J Mol Endocrinol. 1998
PubMed ID: 9513091
Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.
Enslen H, Raingeaud J, Davis RJ
J Biol Chem. 1998
PubMed ID: 9430721
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus.
Brunn GJ, Fadden P, Haystead TA, Lawrence JC
J Biol Chem. 1997
PubMed ID: 9405468
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.
Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z
J Biol Chem. 1997
PubMed ID: 9295308
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.
Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H
Science. 1997
PubMed ID: 9278512
Ras effectors and their role in mitogenesis and oncogenesis.
Joneson T, Bar-Sagi D
J Mol Med. 1997
PubMed ID: 9297626
p38-2, a novel mitogen-activated protein kinase with distinct properties.
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS
J Biol Chem. 1997
PubMed ID: 9235954
Stress, apoptosis, and mitosis induce phosphorylation of human keratin 8 at Ser-73 in tissues and cultured cells.
Liao J, Ku NO, Omary MB
J Biol Chem. 1997
PubMed ID: 9211903
Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.
Tournier C, Whitmarsh AJ, Cavanagh J, Barrett T, Davis RJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207092
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
Fukunaga R, Hunter T
EMBO J. 1997
PubMed ID: 9155018
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA
EMBO J. 1997
PubMed ID: 9155017
Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes.
Fadden P, Haystead TA, Lawrence JC
J Biol Chem. 1997
PubMed ID: 9092573
Convergence of MAP kinase pathways on the ternary complex factor Sap-1a.
Janknecht R, Hunter T
EMBO J. 1997
PubMed ID: 9130707
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.
Tong L, Pav S, White DM, Rogers S, Crane KM, Cywin CL, Brown ML, Pargellis CA
Nat Struct Biol. 1997
PubMed ID: 9095200
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation.
Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ
Nature. 1997
PubMed ID: 9069290
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution.
Wang Z, Harkins PC, Ulevitch RJ, Han J, Cobb MH, Goldsmith EJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9122194
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.
Su YC, Han J, Xu S, Cobb M, Skolnik EY
EMBO J. 1997
PubMed ID: 9135144
Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver.
Mendelson KG, Contois LR, Tevosian SG, Davis RJ, Paulson KE
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8917518
p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2.
Kramer RM, Roberts EF, Um SL, Börsch-Haubold AG, Watson SP, Fisher MJ, Jakubowski JA
J Biol Chem. 1996
PubMed ID: 8910365
Crystal structure of p38 mitogen-activated protein kinase.
Wilson KP, Fitzgibbon MJ, Caron PR, Griffith JP, Chen W, McCaffrey PG, Chambers SP, Su MS
J Biol Chem. 1996
PubMed ID: 8910361
In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor.
Lim R, Zaheer A
J Biol Chem. 1996
PubMed ID: 8798479
Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking.
Robinson A, Gibbins J, Rodríguez-Liñares B, Finan PM, Wilson L, Kellie S, Findell P, Watson SP
Blood. 1996
PubMed ID: 8695800
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase.
Wang XZ, Ron D
Science. 1996
PubMed ID: 8650547
Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade.
Stein B, Brady H, Yang MX, Young DB, Barbosa MS
J Biol Chem. 1996
PubMed ID: 8626699
SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases.
Mertens S, Craxton M, Goedert M
FEBS Lett. 1996
PubMed ID: 8925912
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
Raingeaud J, Whitmarsh AJ, Barrett T, Dérijard B, Davis RJ
Mol Cell Biol. 1996
PubMed ID: 8622669
Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.
Kumar S, McLaughlin MM, McDonnell PC, Lee JC, Livi GP, Young PR
J Biol Chem. 1995
PubMed ID: 7493921
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.
Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P
EMBO J. 1995
PubMed ID: 8846784
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.
Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U, Gaestel M
J Biol Chem. 1995
PubMed ID: 7592979
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.
Zervos AS, Faccio L, Gatto JP, Kyriakis JM, Brent R
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7479834
Activation of ternary complex factor Elk-1 by stress-activated protein kinases.
Gille H, Strahl T, Shaw PE
Curr Biol. 1995
PubMed ID: 8548291
Localization of the human stress responsive MAP kinase-like CSAIDs binding protein (CSBP) gene to chromosome 6q21.3/21.2.
McDonnell PC, DiLella AG, Lee JC, Young PR
Genomics. 1995
PubMed ID: 8530093
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
Doza YN, Cuenda A, Thomas GM, Cohen P, Nebreda AR
FEBS Lett. 1995
PubMed ID: 7750576
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M
Science. 1995
PubMed ID: 7716521
Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ
J Biol Chem. 1995
PubMed ID: 7535770
Molecular cloning of human p38 MAP kinase.
Han J, Richter B, Li Z, Kravchenko V, Ulevitch RJ
Biochim Biophys Acta. 1995
PubMed ID: 7696354
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms.
Dérijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, Davis RJ
Science. 1995
PubMed ID: 7839144
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW
Nature. 1994
PubMed ID: 7997261
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J
Cell. 1994
PubMed ID: 7923354
Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
Haystead TA, Haystead CM, Hu C, Lin TA, Lawrence JC
J Biol Chem. 1994
PubMed ID: 8083223
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.
Han J, Lee JD, Bibbs L, Ulevitch RJ
Science. 1994
PubMed ID: 7914033
Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.
Schultz SJ, Nigg EA
Cell Growth Differ. 1993
PubMed ID: 8274451
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.
Ershler M, Nagorskaya TV, Visser JW, Belyavsky AV
Gene. 1993
PubMed ID: 8444355
Somatic cell hybrid mapping on mouse chromosome 11 (MMU11): assignment of markers relative to two breakpoints in band D.
Morris DJ, Adler ID, Robinson TJ
Genomics. 1993
PubMed ID: 8449498
[Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells]
Ershler MA, Nagorskaia TV, Fisser IaV, Beliavskiĭ AV
Dokl Akad Nauk. 1992
PubMed ID: 1459009
Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition.
Williams AF, Barclay AN, Letarte-Muirhead M, Morris RJ
Cold Spring Harb Symp Quant Biol. 1977
PubMed ID: 70317
[Study of the heterogenetic antigens in vaccinal preparations of V. cholerae]
Zhukov-Verezhnikov NN, Anisimov PI, Goncharova NS, Bochko GM, Karaseva ZN
Biull Eksp Biol Med. 1976
PubMed ID: 1088347

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1432	26416	81649
EnsEMBL Gene(s)	ENSG00000112062	ENSMUSG00000053436	ENSRNOG00000000513
Unigene	Hs.485233	Mm.311337	Rn.88085
Homologene	MAPK14	Mapk14	Mapk14
OMIM	600289	N/A	N/A
GeneCards	MAPK14	N/A	N/A
Beta Cell Genomics	DT.100732109 DT.100843331 DT.118633 DT.121316865 DT.91755525	DT.101259998 DT.101368889 DT.110556628 DT.495086 DT.94167104	N/A
Reactome	Q16539	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1432	26416	81649

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
MAPK14	MUC12	IntAct, BioGRID	empirical	20936779
MAPK14	CDX2	HPRD	empirical	16027724
MAPK14	TAB1	HPRD, MINT, BioGRID	empirical	11847341 21900206 21607062
MAPK14	ZNHIT1	HPRD, MINT, IntAct, BioGRID	empirical	17380123 18624398
MAPK14	CENPC1	IntAct, BioGRID	empirical	18624398
MAPK14	CAMKK2	IntAct, BioGRID	empirical	20562859
MAPK14	PPARGC1A	HPRD	empirical	11741533
MAPK14	COPS5	IntAct, BioGRID	empirical	18624398
MAPK14	DUSP10	HPRD, IntAct, BioGRID	empirical	10391943 10597297 11359773 20936779 11157753
MAPK14	JDP2	HPRD	empirical	12225289 11602244
MAPK14	COPB1	MINT, IntAct	empirical	15102471
MAPK14	CREB1	HPRD	empirical	11377386
MAPK14	ATF2	HPRD, MINT, BioGRID	empirical	7535770 12110590 11259586 10085140 15304344 17380123 11279118 9207092
MAPK14	MAPK14	BioGRID	empirical	12819782 11847341
MAPK14	CSNK2A1	BioGRID	empirical	10747897
MAPK14	CSNK2A2	HPRD	empirical	10747897
MAPK14	CSNK2B	HPRD, BioGRID	empirical	10747897 20797629
MAPK14	GADD45A	HPRD, BioGRID	empirical	12748288
MAPK14	DDIT3	HPRD	empirical	8650547
MAPK14	AES	IntAct, BioGRID	empirical	20936779
MAPK14	DUSP1	HPRD, IntAct, BioGRID	empirical	7535770 20936779 11359773 11278799
MAPK14	DUSP2	HPRD	empirical	7535770
MAPK14	DUSP4	HPRD, BioGRID	empirical	11387337 11062068
MAPK14	DUSP6	BioGRID	empirical	11359773
MAPK14	DUSP7	HPRD	empirical	9788880
MAPK14	DUSP9	HPRD	empirical	11988087
MAPK14	EEF1A1	IntAct, BioGRID	empirical	18624398
MAPK14	EGFR	BioGRID	empirical	7535770 17139251
MAPK14	EIF4EBP1	HPRD	empirical	11777913
MAPK14	ELK1	HPRD	empirical	8622669 9130707 8548291
MAPK14	ELK3	HPRD	empirical	11042694
MAPK14	DDX26B	IntAct, BioGRID	empirical	20936779
MAPK14	EPB42	IntAct, BioGRID	empirical	18624398
MAPK14	EPHB2	MINT	empirical	17255949
MAPK14	AKT1	BioGRID	empirical	11042204
MAPK14	ESR1	HPRD	empirical	12138194
MAPK14	ETV1	BioGRID	empirical	11551945
MAPK14	CEP164	IntAct	empirical	21988832
MAPK14	FLNA	HPRD, IntAct, BioGRID	empirical	11390380 20936779
MAPK14	SNAPIN	IntAct, BioGRID	empirical	18624398
MAPK14	FKBP8	HPRD, MINT, IntAct	empirical	16169070
MAPK14	STK39	HPRD, IntAct	empirical	10980603 14563843
MAPK14	HTRA2	HPRD, BioGRID	empirical	10644717
MAPK14	GMFB	HPRD, BioGRID	empirical	8798479
MAPK14	MKNK2	HPRD, IntAct, BioGRID	empirical	12897141 20936779
MAPK14	GRB2	HPRD	empirical	8695800
MAPK14	GSTP1	IntAct	empirical	16636664
MAPK14	EEF2K	HPRD	empirical	12171600
MAPK14	HIVEP1	IntAct, BioGRID	empirical	20936779
MAPK14	HNF4A	HPRD	empirical	16351573
MAPK14	HSF4	HPRD	empirical	16581800
MAPK14	IKBKB	BioGRID	empirical	20797629
MAPK14	IL2RG	MINT, IntAct	empirical	15102471
MAPK14	IRAK1	HPRD	empirical	10346818
MAPK14	JUNB	HPRD	empirical	9889198 8917518
MAPK14	KARS	BioGRID	empirical	12819782
MAPK14	KRT8	HPRD, BioGRID	empirical	11788583 11781324 9211903
MAPK14	KRT18	HPRD	empirical	11788583
MAPK14	MAFA	HPRD	empirical	11416124
MAPK14	LCP1	MINT, IntAct	empirical	15102471
MAPK14	LIMK1	MINT	empirical	16456544
MAPK14	NBR1	BioGRID	empirical	20616007
MAPK14	SMAD3	HPRD	empirical	14512875
MAPK14	SMAD7	HPRD, BioGRID	empirical	12589052
MAPK14	MARS	HPRD	empirical	9878398
MAPK14	MAX	HPRD	empirical	7479834
MAPK14	MBP	HPRD	empirical	15728454
MAPK14	MEF2A	HPRD, BioGRID, Reactome	empirical	10330143 9858528 10849446 9988769 9069290 10805738
MAPK14	MEF2C	HPRD, IntAct, BioGRID, Reactome	empirical	10330143 9753748 10805738 9069290 20936779 9988769 9858528
MAPK14	MEF2D	IntAct, BioGRID	empirical	20936779
MAPK14	MITF	HPRD	empirical	11792706
MAPK14	NFATC1	HPRD	empirical	15304486
MAPK14	NFATC4	HPRD	empirical	11997522
MAPK14	NFKBIA	BioGRID	empirical	20797629
MAPK14	NKTR	IntAct, BioGRID	empirical	20936779
MAPK14	NME2	MINT, IntAct	empirical	15102471
MAPK14	MYEF2	BioGRID	empirical	15111488
MAPK14	PLA2G4A	HPRD	empirical	9468497
MAPK14	PLCB2	BioGRID	empirical	12054652
MAPK14	PLG	IntAct	empirical	21988832
MAPK14	PML	HPRD	empirical	15273249
MAPK14	YY1AP1	IntAct, BioGRID	empirical	20936779 21988832
MAPK14	PI4K2B	BioGRID	empirical	16949365
MAPK14	TMEM63B	IntAct	empirical	21988832
MAPK14	FAM48A	HPRD, IntAct, BioGRID	empirical	16751104 20936779 21988832
MAPK14	SMEK1	IntAct, BioGRID	empirical	20936779
MAPK14	CCAR1	MINT, IntAct	empirical	15102471
MAPK14	PRKCE	IntAct	empirical	11139474
MAPK14	PKN1	IntAct	empirical	12761180
MAPK14	MAPK1	HPRD, MINT, BioGRID	empirical	12697810 17255949 11157753
MAPK14	MAPK3	HPRD, BioGRID	empirical	12697810
MAPK14	MAPK8	HPRD	empirical	15778365
MAPK14	MAPK11	MINT, IntAct, BioGRID	empirical	15102471 21900206
MAPK14	MAPK9	MINT, IntAct	empirical	15102471
MAPK14	MAP2K1	HPRD	empirical	12697810
MAPK14	MAP2K3	MINT, BioGRID	empirical	17255949 11062068 11279118
MAPK14	MAP2K6	HPRD, MINT, BioGRID	empirical	8626699 7750576 8622669 16342939 9808624 17255949 12697810 11062068 11279118
MAPK14	MAP2K7	BioGRID	empirical	9207092
MAPK14	PAK6	BioGRID	empirical	21900206
MAPK14	DUSP22	HPRD	empirical	11346645
MAPK14	MIB1	MINT, IntAct	empirical	15102471
MAPK14	PTPN7	HPRD	empirical	10559944 10206983 10415025
MAPK14	MLL3	IntAct, BioGRID	empirical	20936779
MAPK14	RB1	MINT, IntAct	empirical	17380128 20871633
MAPK14	RCN2	MINT, IntAct	empirical	15102471
MAPK14	BCL2	HPRD	empirical	11495898
MAPK14	RELA	BioGRID	empirical	21900206
MAPK14	RET	HPRD	empirical	16153436
MAPK14	ROBO1	IntAct, BioGRID	empirical	20936779
MAPK14	RPL22	IntAct, BioGRID	empirical	18624398
MAPK14	RPL41	IntAct, BioGRID	empirical	18624398
MAPK14	RPS6KA3	BioGRID	empirical	11157753
MAPK14	RPS6KB1	BioGRID	empirical	11279232
MAPK14	MAPK12	MINT, IntAct	empirical	15102471
MAPK14	SCN8A	HPRD	empirical	16014723
MAPK14	BICD1	IntAct	empirical	21988832
MAPK14	ZFYVE20	HPRD	empirical	16138080
MAPK14	MAP2K4	HPRD	empirical	7716521 9808624
MAPK14	SRSF5	IntAct, BioGRID	empirical	18624398
MAPK14	ARHGAP9	IntAct	empirical	17284314
MAPK14	SHC1	HPRD	empirical	15688026
MAPK14	CCDC14	IntAct, BioGRID	empirical	20936779
MAPK14	NCF1	HPRD	empirical	15629715
MAPK14	SLC9A1	HPRD	empirical	11604491
MAPK14	SLC12A2	IntAct, BioGRID	empirical	14563843
MAPK14	SP1	MINT, IntAct, BioGRID	empirical	15102471 18419748
MAPK14	SPTBN1	IntAct, BioGRID	empirical	20936779
MAPK14	ZFP36L1	HPRD, MINT, IntAct	empirical	16189514
MAPK14	STAT1	HPRD	empirical	11226159
MAPK14	STAT4	HPRD	empirical	10961885
MAPK14	MAP3K7	HPRD	empirical	12589052
MAPK14	TCF20	IntAct, BioGRID	empirical	20936779
MAPK14	TFCP2	BioGRID	empirical	15857981
MAPK14	TRAF6	HPRD	empirical	10346818
MAPK14	TSC1	IntAct	empirical	20368287
MAPK14	UBC	BioGRID	empirical	21139048 21890473
MAPK14	UGT2B10	IntAct	empirical	21988832
MAPK14	ZNF142	IntAct, BioGRID	empirical	20936779
MAPK14	MAPKAPK3	HPRD, BioGRID, Reactome	empirical	11157753 9768359 12171911 7535770 8622669 17395714 8846784 17255097 15287722
MAPK14	MOB3B	IntAct, BioGRID	empirical	20936779
MAPK14	DUSP16	HPRD, IntAct, BioGRID	empirical	11359773 11489891 14586399 20936779
MAPK14	NCOA3	HPRD, MINT	empirical	16135815 15383283 16456540
MAPK14	EEA1	HPRD	empirical	16138080
MAPK14	MAPKAPK5	HPRD, IntAct, BioGRID	empirical	9628874 20936779
MAPK14	MKNK1	HPRD, IntAct, BioGRID	empirical	9155018 20936779 11157753
MAPK14	FUBP1	BioGRID	empirical	12819782
MAPK14	BTRC	BioGRID	empirical	20797629
MAPK14	RPS6KA4	HPRD, IntAct, BioGRID	empirical	9792677 10806207
MAPK14	BAZ1B	BioGRID	empirical	19776015
MAPK14	CCDC97	IntAct, BioGRID	empirical	20936779
MAPK14	SPAG9	HPRD, BioGRID	empirical	12391307
MAPK14	DYRK1B	HPRD, BioGRID	empirical	10910078
MAPK14	C14orf43	IntAct, BioGRID	empirical	20936779
MAPK14	CD4	BioGRID	empirical	20530479
MAPK14	RPS6KA5	IntAct, BioGRID	empirical	20936779 11157753
MAPK14	AIMP1	HPRD	empirical	9878398
MAPK14	MAPKAPK2	HPRD, IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	8846784 7592979 9768359 17255097 21988832 11042204 11551945 12171911 7535770 8622669 17395714 15287722 15345047
MAPK14	GDF15	IntAct	empirical	18624398
MAPK14	CDC25A	BioGRID	empirical	12963847
MAPK14	CDC25B	BioGRID	empirical	11333986
MAPK14	CDC25C	HPRD, BioGRID	empirical	11333986 10557092 9278512 11551930
MAPK14	NUP153	HPRD, MINT	empirical	17255949