PARP1

Summary Top Help

Gene Description:

poly (ADP-ribose) polymerase family, member 1; poly (ADP-ribose) polymerase 1

Synonyms:

C80510, PARP-1, Adprp, sPARP-1, PARP, Parp-1, Adprt, AI893648, Adprt1, pADPRT-1, Parp1, PARP1, ADPRT1, 5830444G22Rik, ADPRT, PPOL, parp-1

Orthologs:

Human PARP1 (protein-coding), Mouse Parp1 (protein-coding), Rat Parp1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr1:226548392..226595801 (47.41 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:182499086..182531385 (32.30 kb) View in Genome Browser

(Rat) RGSC3.4 - chr13:96309670..96341486 (31.82 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for PARP1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for PARP1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 7

Reactome: None available

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 26

Publications from PubMed Top Help

Type 1 Diabetes Publications: 10

Identification of PARP-1 as one of the transcription factors binding to the repressor element in the promoter region of COX-2.
Lin Y, Tang X, Zhu Y, Shu T, Han X
Arch Biochem Biophys. 2011
PubMed ID: 20868648
Poly(Adenosine 5'-Diphosphate-Ribose) Polymerase Inhibition Counteracts Multiple Manifestations of Experimental Type 1 Diabetic Nephropathy.
Drel VR, Xu W, Zhang J, Pavlov IA, Shevalye H, Slusher B, Obrosova IG
Endocrinology. 2009
PubMed ID: 19854869
Roles of inhibitors of poly(ADP-ribose) polymerase in protecting rat RINm5F cell line against free fatty acid-induced apoptosis.
Mao X, Wang S, Pan Y, He B, Chen J, Jiang H, Zeng Q, Xu X
Exp Clin Endocrinol Diabetes. 2009
PubMed ID: 19513971
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Sumara G, Formentini I, Collins S, Sumara I, Windak R, Bodenmiller B, Ramracheya R, Caille D, Jiang H, Platt KA, Meda P, Aebersold R, Rorsman P, Ricci R
Cell. 2009
PubMed ID: 19135240
Leu54Phe and Val762Ala polymorphisms in the poly(ADP-ribose)polymerase-1 gene are associated with diabetic polyneuropathy in Russian type 1 diabetic patients.
Nikitin AG, Chudakova DA, Strokov IA, Bursa TR, Chistiakov DA, Nosikov VV
Diabetes Res Clin Pract. 2008
PubMed ID: 18054108
Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.
Gonzalez C, Ménissier De Murcia J, Janiak P, Bidouard JP, Beauvais C, Karray S, Garchon HJ, Lévi-Strauss M
Diabetes. 2002
PubMed ID: 11978644
A dinucleotide repeat polymorphism at the poly(ADP-ribose) polymerase gene is not associated with predisposition to type 1 diabetes in French Caucasians.
Delrieu O, Dubois-Laforgue D, Timsit J, Tournier-Lasserve E, Caillat-Zucman S
J Autoimmun. 2001
PubMed ID: 11591122
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
Shall S, de Murcia G
Mutat Res. 2000
PubMed ID: 10856830
Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes.
Masutani M, Suzuki H, Kamada N, Watanabe M, Ueda O, Nozaki T, Jishage K, Watanabe T, Sugimoto T, Nakagama H, Ochiya T, Sugimura T
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10051636
Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin.
Burkart V, Wang ZQ, Radons J, Heller B, Herceg Z, Stingl L, Wagner EF, Kolb H
Nat Med. 1999
PubMed ID: 10086388

Publications: 825

Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion.
Terashima T, Kojima H, Chan L
FASEB J. 2012
PubMed ID: 21978940
Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).
Hooten NN, Kompaniez K, Barnes J, Lohani A, Evans MK
J Biol Chem. 2011
PubMed ID: 22057269
Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons.
Mandraju R, Chekuri A, Bhaskar C, Duning K, Kremerskothen J, Kondapi AK
Arch Biochem Biophys. 2011
PubMed ID: 22019940
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Suppression of matrix metalloproteinase-9 expression in undifferentiated, non-apoptotic keratinocytes is abrogated by the cleavage of poly(ADP-ribose) polymerase-1.
Kobayashi T
Apoptosis. 2011
PubMed ID: 21915713
Lymph node metastasis of gastric cancer is associated with the interaction between poly (ADP-ribose) polymerase 1 and matrix metallopeptidase 2.
Kim J, Pyun JA, Cho SW, Lee K, Kwack K
DNA Cell Biol. 2011
PubMed ID: 21612407
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM
Chem Biol. 2011
PubMed ID: 22118674
Poly(ADP-ribose) polymerase-1 protects from oxidative stress induced endothelial dysfunction.
Gebhard C, Stähli BE, Shi Y, Camici GG, Akhmedov A, Hoegger L, Lohmann C, Matter CM, Hassa PO, Hottiger MO, Malinski T, Lüscher TF, Tanner FC
Biochem Biophys Res Commun. 2011
PubMed ID: 21982765
Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y
J Proteome Res. 2011
PubMed ID: 21942715
Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury.
Mukhopadhyay P, Horváth B, Kechrid M, Tanchian G, Rajesh M, Naura AS, Boulares AH, Pacher P
Free Radic Biol Med. 2011
PubMed ID: 21884784
Pediatric high-grade glioma: identification of poly(ADP-ribose) polymerase as a potential therapeutic target.
Smith SJ, Long A, Barrow JH, Macarthur DC, Coyle B, Grundy RG, Children's Cancer and Leukaemia Group Biological Studies Committee
Neuro Oncol. 2011
PubMed ID: 21849329
Association analysis of PARP1 polymorphisms with Parkinson's disease.
Brighina L, Riva C, Bertola F, Fermi S, Saracchi E, Piolti R, Goldwurm S, Pezzoli G, Ferrarese C
Parkinsonism Relat Disord. 2011
PubMed ID: 21767974
Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.
Rodríguez MI, González-Flores A, Dantzer F, Collard J, de Herreros AG, Oliver FJ
Oncogene. 2011
PubMed ID: 21577210
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
Hempel C, Combes V, Hunt NH, Kurtzhals JA, Grau GE
Am J Pathol. 2011
PubMed ID: 21854739
Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling.
Berndt JD, Aoyagi A, Yang P, Anastas JN, Tang L, Moon RT
J Cell Biol. 2011
PubMed ID: 21875946
Involvement of protein kinase Cdelta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells.
Mizuguchi H, Terao T, Kitai M, Ikeda M, Yoshimura Y, Das AK, Kitamura Y, Takeda N, Fukui H
J Biol Chem. 2011
PubMed ID: 21730054
Notch signaling protects retina from nuclear factor-κB- and poly-ADP-ribose-polymerase-mediated apoptosis under high-glucose stimulation.
Qin X, Zhang Z, Xu H, Wu Y
Acta Biochim Biophys Sin (Shanghai). 2011
PubMed ID: 21813561
In vivo repair of DNA damage induced by X-rays in the early stages of mouse fertilization, and the influence of maternal PARP1 ablation.
Pacchierotti F, Ranaldi R, Derijck AA, van der Heijden GW, de Boer P
Mutat Res. 2011
PubMed ID: 21762709
Ca2+-induced PARP-1 activation and ANF expression are coupled events in cardiomyocytes.
Geistrikh I, Visochek L, Klein R, Miller L, Mittelman L, Shainberg A, Cohen-Armon M
Biochem J. 2011
PubMed ID: 21635224
Expression of antioxidant defense and poly(ADP-ribose) polymerase-1 in rat developing Sertoli cells.
Scarabelli L, Lanza C, Demori I, Accomando R, Giansanti V, Scovassi AI, Palmero S
Cell Biol Int. 2011
PubMed ID: 21375507
Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.
Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21825151
PARP inhibition in atherosclerosis and its effects on dendritic cells, T cells and auto-antibody levels.
Erbel C, Achenbach J, Akhavanpoor M, Dengler TJ, Lasitschka F, Gleissner CA, Bea F, Katus HA, Szabo G
Eur J Med Res. 2011
PubMed ID: 21813379
Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis.
Pozo FM, Oda T, Sekimoto T, Murakumo Y, Masutani C, Hanaoka F, Yamashita T
Mol Cell Biol. 2011
PubMed ID: 21690293
SNPs in DNA repair genes associated to meningitis and host immune response.
da Silva TA, Fontes FL, Coutinho LG, de Souza FR, de Melo JT, de Souto JT, Leib SL, Agnez-Lima LF
Mutat Res. 2011
PubMed ID: 21651918
Loss of poly(ADP-ribose) polymerase 1 attenuates renal fibrosis and inflammation during unilateral ureteral obstruction.
Kim J, Padanilam BJ
Am J Physiol Renal Physiol. 2011
PubMed ID: 21613422
Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia.
Liu W, Shen Y, Plane JM, Pleasure DE, Deng W
Exp Neurol. 2011
PubMed ID: 21596035
Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor.
Huang S, Ling JJ, Yang S, Li XJ, Li S
Brain. 2011
PubMed ID: 21705419
Vascular endothelial growth factor confers endothelial resistance to apoptosis through poly(ADP-ribose) polymerase.
Hörmann M, Mey L, Kharip Z, Hildenberg A, Nemeth K, Heidt M, Renz H, Al-Fakhri N
J Thromb Haemost. 2011
PubMed ID: 21605336
Poly(ADP-ribose) polymerase-1: a novel therapeutic target in necrotizing enterocolitis.
Giannone PJ, Alcamo AA, Schanbacher BL, Nankervis CA, Besner GE, Bauer JA
Pediatr Res. 2011
PubMed ID: 21399558
PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
Cavone L, Aldinucci A, Ballerini C, Biagioli T, Moroni F, Chiarugi A
Mult Scler. 2011
PubMed ID: 21343230
PARP-1 deficiency blocks IL-5 expression through calpain-dependent degradation of STAT-6 in a murine asthma model.
Datta R, Naura AS, Zerfaoui M, Errami Y, Oumouna M, Kim H, Ju J, Ronchi VP, Haas AL, Boulares AH
Allergy. 2011
PubMed ID: 21276008
iNOS induction and PARP-1 activation in human atherosclerotic lesions: an immunohistochemical and ultrastructural approach.
Perrotta I, Brunelli E, Sciangula A, Conforti F, Perrotta E, Tripepi S, Donato G, Cassese M
Cardiovasc Pathol. 2011
PubMed ID: 20619687
SIRT6 promotes DNA repair under stress by activating PARP1.
Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V
Science. 2011
PubMed ID: 21680843
Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS).
Ohanna M, Giuliano S, Bonet C, Imbert V, Hofman V, Zangari J, Bille K, Robert C, Bressac-de Paillerets B, Hofman P, Rocchi S, Peyron JF, Lacour JP, Ballotti R, Bertolotto C
Genes Dev. 2011
PubMed ID: 21646373
Poly(ADP-ribose) polymerase-1 (PARP-1) pharmacogenetics, activity and expression analysis in cancer patients and healthy volunteers.
Zaremba T, Thomas HD, Cole M, Coulthard SA, Plummer ER, Curtin NJ
Biochem J. 2011
PubMed ID: 21434873
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, Ten Hagen TL, Kanaar R, Aten JA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21555554
Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein.
Lu H, Wang X, Li T, Urvalek AM, Yu L, Li J, Zhu J, Lin Q, Peng X, Zhao J
J Biol Chem. 2011
PubMed ID: 21518760
Thrombomodulin is silenced in malignant mesothelioma by a poly(ADP-ribose) polymerase-1-mediated epigenetic mechanism.
Nocchi L, Tomasetti M, Amati M, Neuzil J, Santarelli L, Saccucci F
J Biol Chem. 2011
PubMed ID: 21489980
[Effect of erythropoietin on proinflammatory factors of human monocytes and its mechanisms].
Han X, Zhou DB, Xu CM, Yang Y, Duan MH, Wang X, Zhang JP, Zhao YQ, Shen T, Wu YJ
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011
PubMed ID: 21729562
Effect of poly(ADP-ribose) polymerase 1 on integration of the adeno-associated viral vector genome.
Romanova LG, Zacharias J, Cannon ML, Philpott NJ
J Gene Med. 2011
PubMed ID: 21674737
Over expression of LDOC1 and PARP1, two pro-apoptotic genes, in a patient with cryptorchidism and DiGeorge anomaly.
Salemi M, Castiglione R, La Vignera S, Condorelli RA, Bosco P, Vicari E, Calogero AE
Hum Cell. 2011
PubMed ID: 21547351
PARP and RIP 1 are required for autophagy induced by 11'-deoxyverticillin A, which precedes caspase-dependent apoptosis.
Zhang N, Chen Y, Jiang R, Li E, Chen X, Xi Z, Guo Y, Liu X, Zhou Y, Che Y, Jiang X
Autophagy. 2011
PubMed ID: 21460625
PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying.
Li WJ, Oh SJ
Apoptosis. 2011
PubMed ID: 21416227
PARP-1 expression and activity in primary human lung cells.
Ahmad M, Torky A, Glahn F, Scheubel RJ, Foth H
Arch Toxicol. 2011
PubMed ID: 20953586
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.
Brenner JC, Ateeq B, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Wang X, Liang H, Yu J, Palanisamy N, Siddiqui J, Yan W, Cao X, Mehra R, Sabolch A, Basrur V, Lonigro RJ, Yang J, Tomlins SA, Maher CA, Elenitoba-Johnson KS, Hussain M, Navone NM, Pienta KJ, Varambally S, Feng FY, Chinnaiyan AM
Cancer Cell. 2011
PubMed ID: 21575865
PARP-1 regulates the expression of caspase-11.
Yoo L, Hong S, Shin KS, Kang SJ
Biochem Biophys Res Commun. 2011
PubMed ID: 21530491
[Role of poly (ADP-ribose) polymerase 1 on DNA methylation variation induced by B(a)P in human bronchial epithelial cell].
Tao GH, Gong CM, Yang LQ, Liu QC, Liu JD, Wu DS, Hu XN, Huang HY, Liu JJ, Ke YB, Zhuang ZX
Zhonghua Yu Fang Yi Xue Za Zhi. 2011
PubMed ID: 21756783
p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.
Meng F, Zhang H, Liu G, Kreike B, Chen W, Sethi S, Miller FR, Wu G
Neoplasia. 2011
PubMed ID: 21532888
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A
Nat Cell Biol. 2011
PubMed ID: 21478856
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.
Meyer-Ficca ML, Lonchar JD, Ihara M, Meistrich ML, Austin CA, Meyer RG
Biol Reprod. 2011
PubMed ID: 21228215
Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.
Dedes KJ, Wilkerson PM, Wetterskog D, Weigelt B, Ashworth A, Reis-Filho JS
Cell Cycle. 2011
PubMed ID: 21487248
An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts.
Matsushima S, Okita N, Oku M, Nagai W, Kobayashi M, Higami Y
Biochem Biophys Res Commun. 2011
PubMed ID: 21419099
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Bai P, Cantó C, Oudart H, Brunyánszki A, Cen Y, Thomas C, Yamamoto H, Huber A, Kiss B, Houtkooper RH, Schoonjans K, Schreiber V, Sauve AA, Menissier-de Murcia J, Auwerx J
Cell Metab. 2011
PubMed ID: 21459330
PARP-2 regulates SIRT1 expression and whole-body energy expenditure.
Bai P, Canto C, Brunyánszki A, Huber A, Szántó M, Cen Y, Yamamoto H, Houten SM, Kiss B, Oudart H, Gergely P, Menissier-de Murcia J, Schreiber V, Sauve AA, Auwerx J
Cell Metab. 2011
PubMed ID: 21459329
Sex differences in the response to poly(ADP-ribose) polymerase-1 deletion and caspase inhibition after stroke.
Liu F, Lang J, Li J, Benashski SE, Siegel M, Xu Y, McCullough LD
Stroke. 2011
PubMed ID: 21311064
Intramyocardial administration of chimeric ephrinA1-Fc promotes tissue salvage following myocardial infarction in mice.
Dries JL, Kent SD, Virag JA
J Physiol. 2011
PubMed ID: 21282286
Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: structural and functional insights into DNA-dependent PARP-1 activity.
Langelier MF, Planck JL, Roy S, Pascal JM
J Biol Chem. 2011
PubMed ID: 21233213
Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.
Kannan S, Fang W, Song G, Mullighan CG, Hammitt R, McMurray J, Zweidler-McKay PA
Blood. 2011
PubMed ID: 21224467
Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair.
Paddock MN, Bauman AT, Higdon R, Kolker E, Takeda S, Scharenberg AM
DNA Repair (Amst). 2011
PubMed ID: 21256093
Double-stranded DNA binding domain of poly(ADP-ribose) polymerase-1 and molecular insight into the regulation of its activity.
Huambachano O, Herrera F, Rancourt A, Satoh MS
J Biol Chem. 2011
PubMed ID: 21183686
Expression of poly (adenosine diphosphate-ribose) polymerase and p53 in epithelial ovarian cancer and their role in prognosis and disease outcome.
Godoy H, Mhawech-Fauceglia P, Beck A, Miller A, Lele S, Odunsi K
Int J Gynecol Pathol. 2011
PubMed ID: 21293287
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
Hans CP, Feng Y, Naura AS, Troxclair D, Zerfaoui M, Siddiqui D, Jihang J, Kim H, Kaye AD, Matrougui K, Lazartigues E, Boulares AH
Cardiovasc Pathol. 2011
PubMed ID: 20434371
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.
Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21270334
hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.
Chang HY, Fan CC, Chu PC, Hong BE, Lee HJ, Chang MS
Cancer Res. 2011
PubMed ID: 21266351
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis.
Meyer-Ficca ML, Ihara M, Lonchar JD, Meistrich ML, Austin CA, Min W, Wang ZQ, Meyer RG
Biol Reprod. 2011
PubMed ID: 20881315
Poly(ADP-ribose) polymerase signaling of topoisomerase 1-dependent DNA damage in carcinoma cells.
D'Onofrio G, Tramontano F, Dorio AS, Muzi A, Maselli V, Fulgione D, Graziani G, Malanga M, Quesada P
Biochem Pharmacol. 2011
PubMed ID: 20875401
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.
Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21187397
Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β.
Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA
J Neuroinflammation. 2011
PubMed ID: 22051244
Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.
Kong X, Stephens J, Ball AR, Heale JT, Newkirk DA, Berns MW, Yokomori K
PLoS One. 2011
PubMed ID: 21858164
Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats.
Kaur J, Mencl S, Sahaboglu A, Farinelli P, van Veen T, Zrenner E, Ekström P, Paquet-Durand F, Arango-Gonzalez B
PLoS One. 2011
PubMed ID: 21765948
Interaction of poly(ADP-ribose) polymerase 1 with apurinic/apyrimidinic sites within clustered DNA damage.
Kutuzov MM, Ilina ES, Sukhanova MV, Pyshnaya IA, Pyshnyi DV, Lavrik OI, Khodyreva SN
Biochemistry (Mosc). 2011
PubMed ID: 21568846
PARP-1 activity in normal and cancerous human endometrium and its relationship with quantity of abasic sites (AP).
Postawski K, Monist M, Keith G
Ginekol Pol. 2011
PubMed ID: 21469519
MYC, PARP1, and chemoresistance: BIN there, done that?
Ganesan S
Sci Signal. 2011
PubMed ID: 21447796
Poly(ADP-ribose) polymerase-1 inhibition: preclinical and clinical development of synthetic lethality.
Leung M, Rosen D, Fields S, Cesano A, Budman DR
Mol Med. 2011
PubMed ID: 21424107
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes.
Pang J, Gong H, Xi C, Fan W, Dai Y, Zhang TM
J Cell Biochem. 2011
PubMed ID: 21031461
Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity.
Bakondi E, Catalgol B, Bak I, Jung T, Bozaykut P, Bayramicli M, Ozer NK, Grune T
Free Radic Biol Med. 2011
PubMed ID: 20977936
Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1).
Khodyreva SN, Prasad R, Ilina ES, Sukhanova MV, Kutuzov MM, Liu Y, Hou EW, Wilson SH, Lavrik OI
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21127267
Increased levels of p53 and PARP-1 in EL-4 cells probably related with the immune adaptive response induced by low dose ionizing radiation in vitro.
Cheng GH, Wu N, Jiang DF, Zhao HG, Zhang Q, Wang JF, Gong SL
Biomed Environ Sci. 2010
PubMed ID: 21315248
Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.
Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, Baron JA, Martinez ME, Haile RW, Ahnen DJ, Sandler RS, Lance P, Stern MC
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 21037106
Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis.
Min W, Cortes U, Herceg Z, Tong WM, Wang ZQ
Carcinogenesis. 2010
PubMed ID: 20926829
Poly(ADP-ribose) polymerase-1 (PARP-1) contributes to the barrier function of a vertebrate chromatin insulator.
Aker M, Bomsztyk K, Emery DW
J Biol Chem. 2010
PubMed ID: 20876582
PARP-1 attenuates Smad-mediated transcription.
Lönn P, van der Heide LP, Dahl M, Hellman U, Heldin CH, Moustakas A
Mol Cell. 2010
PubMed ID: 21095583
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.
Wendorff AA, Koch U, Wunderlich FT, Wirth S, Dubey C, Brüning JC, MacDonald HR, Radtke F
Immunity. 2010
PubMed ID: 21093323
Bioorthogonal small-molecule ligands for PARP1 imaging in living cells.
Reiner T, Earley S, Turetsky A, Weissleder R
Chembiochem. 2010
PubMed ID: 20967817
C-terminal binding protein and poly(ADP)ribose polymerase 1 contribute to repression of the p21(waf1/cip1) promoter.
Madison DL, Lundblad JR
Oncogene. 2010
PubMed ID: 20711239
Cooperative role of NF-{kappa}B and poly(ADP-ribose) polymerase 1 (PARP-1) in the TNF-induced inhibition of PHEX expression in osteoblasts.
Majewski PM, Thurston RD, Ramalingam R, Kiela PR, Ghishan FK
J Biol Chem. 2010
PubMed ID: 20817730
Delayed activation of caspase-independent apoptosis during heart failure in transgenic mice overexpressing caspase inhibitor CrmA.
Bae S, Siu PM, Choudhury S, Ke Q, Choi JH, Koh YY, Kang PM
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20833960
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.
Kim M, Kang HG, Lee SY, Lee HC, Lee EB, Choi YY, Lee WK, Cho S, Jin G, Jheon HS, Son JW, Lee MH, Jung DK, Cha SI, Kim CH, Kang YM, Kam S, Jung TH, Jheon S, Park JY
Cancer Sci. 2010
PubMed ID: 20731661
PARP1 suppresses homologous recombination events in mice in vivo.
Claybon A, Karia B, Bruce C, Bishop AJ
Nucleic Acids Res. 2010
PubMed ID: 20660013
Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease.
Shevalye H, Maksimchyk Y, Watcho P, Obrosova IG
Biochim Biophys Acta. 2010
PubMed ID: 20621183
Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress.
Brunyánszki A, Hegedus C, Szántó M, Erdélyi K, Kovács K, Schreiber V, Gergely S, Kiss B, Szabó E, Virág L, Bai P
J Invest Dermatol. 2010
PubMed ID: 20613774
Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Dong Y, Bey EA, Li LS, Kabbani W, Yan J, Xie XJ, Hsieh JT, Gao J, Boothman DA
Cancer Res. 2010
PubMed ID: 20940411
Histone H1 poly[ADP]-ribosylation regulates the chromatin alterations required for learning consolidation.
Fontán-Lozano A, Suárez-Pereira I, Horrillo A, del-Pozo-Martín Y, Hmadcha A, Carrión AM
J Neurosci. 2010
PubMed ID: 20926656
SOX9 induces and maintains neural stem cells.
Scott CE, Wynn SL, Sesay A, Cruz C, Cheung M, Gomez Gaviro MV, Booth S, Gao B, Cheah KS, Lovell-Badge R, Briscoe J
Nat Neurosci. 2010
PubMed ID: 20871603
Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1.
Yosunkaya E, Kucukyuruk B, Onaran I, Gurel CB, Uzan M, Kanigur-Sultuybek G
Br J Neurosurg. 2010
PubMed ID: 20868244
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
The roles of PARP1 in gene control and cell differentiation.
Ji Y, Tulin AV
Curr Opin Genet Dev. 2010
PubMed ID: 20591646
PARP1 ADP-ribosylates lysine residues of the core histone tails.
Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
Nucleic Acids Res. 2010
PubMed ID: 20525793
Kainate-mediated excitotoxicity induces neuronal death in the rat spinal cord in vitro via a PARP-1 dependent cell death pathway (Parthanatos).
Kuzhandaivel A, Nistri A, Mladinic M
Cell Mol Neurobiol. 2010
PubMed ID: 20502958
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding.
Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U
Cell. 2010
PubMed ID: 20832105
Genetic variation in DNA repair pathway genes and melanoma risk.
Zhang M, Qureshi AA, Guo Q, Han J
DNA Repair (Amst). 2010
PubMed ID: 20837404
Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer.
Annunziata CM, O'Shaughnessy J
Clin Cancer Res. 2010
PubMed ID: 20823142
Cutting edge: proteolytic inactivation of poly(ADP-ribose) polymerase 1 by the Nlrp3 and Nlrc4 inflammasomes.
Malireddi RK, Ippagunta S, Lamkanfi M, Kanneganti TD
J Immunol. 2010
PubMed ID: 20713892
PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway.
Krishnakumar R, Kraus WL
Mol Cell. 2010
PubMed ID: 20832725
Increased poly(ADP-ribose) polymerase (PARP)-1 expression and activity are associated with inflammation but not goblet cell metaplasia in murine models of allergen-induced airway inflammation.
Havranek T, Aujla PK, Nickola TJ, Rose MC, Scavo LM
Exp Lung Res. 2010
PubMed ID: 20715980
Ethanol-induced downregulation of the angiotensin AT2 receptor in murine fibroblasts is mediated by PARP-1.
Menk M, von Haefen C, Funke-Kaiser H, Sifringer M, Schefe JH, Kirsch S, Seidel K, Reinemund J, Steckelings UM, Unger T, Spies CD
Alcohol. 2010
PubMed ID: 20693103
Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities.
Levros LC, Do Carmo S, Edouard E, Legault P, Charfi C, Rassart E
Biochim Biophys Acta. 2010
PubMed ID: 20493910
Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.
Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I
Arch Biochem Biophys. 2010
PubMed ID: 20493163
Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.
Heacock ML, Stefanick DF, Horton JK, Wilson SH
DNA Repair (Amst). 2010
PubMed ID: 20573551
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Effects of varicocele upon the expression of apoptosis-related proteins.
Chang FW, Sun GH, Cheng YY, Chen IC, Chien HH, Wu GJ
Andrologia. 2010
PubMed ID: 20629644
Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappaB upon TLR4 stimulation.
Zerfaoui M, Errami Y, Naura AS, Suzuki Y, Kim H, Ju J, Liu T, Hans CP, Kim JG, Abd Elmageed ZY, Koochekpour S, Catling A, Boulares AH
J Immunol. 2010
PubMed ID: 20610652
Polymorphisms in the base excision repair pathway and graft-versus-host disease.
Arora M, Lindgren B, Basu S, Nagaraj S, Gross M, Weisdorf D, Thyagarajan B
Leukemia. 2010
PubMed ID: 20574454
Poly (ADP-ribose) polymerase-1 binds to BCL2 major breakpoint region and regulates BCL2 expression.
Yang N, Gong F, Sun L, Yang D, Han X, Ma C, Sun Y
J Cell Biochem. 2010
PubMed ID: 20564216
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation.
Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO
Infect Immun. 2010
PubMed ID: 20515923
BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.
Facchino S, Abdouh M, Chatoo W, Bernier G
J Neurosci. 2010
PubMed ID: 20668194
Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population.
Lee KA, Bang SY, Park BL, Kim JH, Shin HD, Bae SC
Rheumatol Int. 2010
PubMed ID: 20665026
Recognition of platinum-DNA damage by poly(ADP-ribose) polymerase-1.
Zhu G, Chang P, Lippard SJ
Biochemistry. 2010
PubMed ID: 20550106
Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer.
Gao R, Price DK, Dahut WL, Steinberg SM, Reed E, Figg WD
Cancer Biol Ther. 2010
PubMed ID: 20495366
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J. 2010
PubMed ID: 20644561
The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.
Cogoi S, Paramasivam M, Membrino A, Yokoyama KK, Xodo LE
J Biol Chem. 2010
PubMed ID: 20457603
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia.
Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A
Cancer Res. 2010
PubMed ID: 20634404
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium
Am J Epidemiol. 2010
PubMed ID: 20522537
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.
Krishnakumar R, Kraus WL
Mol Cell. 2010
PubMed ID: 20603072
Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.
Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA
Science. 2010
PubMed ID: 20595612
Chromatin regulation by Brg1 underlies heart muscle development and disease.
Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP
Nature. 2010
PubMed ID: 20596014
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
BMP signaling controls formation of a primordial germ cell niche within the early genital ridges.
Dudley B, Palumbo C, Nalepka J, Molyneaux K
Dev Biol. 2010
PubMed ID: 20417197
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.
Drané P, Ouararhni K, Depaux A, Shuaib M, Hamiche A
Genes Dev. 2010
PubMed ID: 20504901
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction.
Langelier MF, Ruhl DD, Planck JL, Kraus WL, Pascal JM
J Biol Chem. 2010
PubMed ID: 20388712
p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1.
Cazzalini O, Donà F, Savio M, Tillhon M, Maccario C, Perucca P, Stivala LA, Scovassi AI, Prosperi E
DNA Repair (Amst). 2010
PubMed ID: 20303835
Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1.
Mangerich A, Herbach N, Hanf B, Fischbach A, Popp O, Moreno-Villanueva M, Bruns OT, Bürkle A
Mech Ageing Dev. 2010
PubMed ID: 20561897
PARP activity and NAD concentration in PMC from patients affected by systemic sclerosis and lupus erythematosus.
Cerboni B, Di Stefano A, Micheli V, Morozzi G, Pompucci G, Sestini S
Nucleosides Nucleotides Nucleic Acids. 2010
PubMed ID: 20544540
Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon.
Huillard E, Ziercher L, Blond O, Wong M, Deloulme JC, Souchelnytskyi S, Baudier J, Cochet C, Buchou T
Mol Cell Biol. 2010
PubMed ID: 20368359
PARP1 deficiency exacerbates diet-induced obesity in mice.
Devalaraja-Narashimha K, Padanilam BJ
J Endocrinol. 2010
PubMed ID: 20338998
Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span.
Beneke S, Scherr AL, Ponath V, Popp O, Bürkle A
Mech Ageing Dev. 2010
PubMed ID: 20399804
Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia.
Li X, Klaus JA, Zhang J, Xu Z, Kibler KK, Andrabi SA, Rao K, Yang ZJ, Dawson TM, Dawson VL, Koehler RC
J Neurochem. 2010
PubMed ID: 20236222
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S
Mol Cell Biol. 2010
PubMed ID: 20231360
Genetic polymorphisms of DNA repair genes and chromosomal damage in workers exposed to 1,3-butadiene.
Wang Q, Wang AH, Tan HS, Feng NN, Ye YJ, Feng XQ, Liu G, Zheng YX, Xia ZL
Carcinogenesis. 2010
PubMed ID: 20223788
Regulation of Epstein-Barr virus OriP replication by poly(ADP-ribose) polymerase 1.
Tempera I, Deng Z, Atanasiu C, Chen CJ, D'Erme M, Lieberman PM
J Virol. 2010
PubMed ID: 20219917
The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells.
Lamore SD, Cabello CM, Wondrak GT
Cell Stress Chaperones. 2010
PubMed ID: 19809895
Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition.
Kondo K, Obitsu S, Ohta S, Matsunami K, Otsuka H, Teshima R
J Biol Chem. 2010
PubMed ID: 20177052
Trypanosoma cruzi induces the reactive oxygen species-PARP-1-RelA pathway for up-regulation of cytokine expression in cardiomyocytes.
Ba X, Gupta S, Davidson M, Garg NJ
J Biol Chem. 2010
PubMed ID: 20145242
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Pardo M, Lang B, Yu L, Prosser H, Bradley A, Babu MM, Choudhary J
Cell Stem Cell. 2010
PubMed ID: 20362542
Triple-negative breast cancer.
Bartsch R, Ziebermayr R, Zielinski CC, Steger GG
Wien Med Wochenschr. 2010
PubMed ID: 20473728
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
Sourisseau T, Maniotis D, McCarthy A, Tang C, Lord CJ, Ashworth A, Linardopoulos S
EMBO Mol Med. 2010
PubMed ID: 20373286
Increased Foxp3+ regulatory T cells in poly(ADP-Ribose) polymerase-1 deficiency.
Nasta F, Laudisi F, Sambucci M, Rosado MM, Pioli C
J Immunol. 2010
PubMed ID: 20208002
The septic shock-associated IL-10 -1082 A > G polymorphism mediates allele-specific transcription via poly(ADP-Ribose) polymerase 1 in macrophages engulfing apoptotic cells.
Kang X, Kim HJ, Ramirez M, Salameh S, Ma X
J Immunol. 2010
PubMed ID: 20181890
Poly(ADP-ribose) polymerase-1 modulates interferon-gamma-inducible protein (IP)-10 expression in murine embryonic fibroblasts by stabilizing IP-10 mRNA.
Galbis-Martínez M, Saenz L, Ramírez P, Parrilla P, Yélamos J
Mol Immunol. 2010
PubMed ID: 20171739
Parp1 activation in mouse embryonic fibroblasts promotes Pol beta-dependent cellular hypersensitivity to alkylation damage.
Jelezcova E, Trivedi RN, Wang XH, Tang JB, Brown AR, Goellner EM, Schamus S, Fornsaglio JL, Sobol RW
Mutat Res. 2010
PubMed ID: 20096707
Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway--do androgens matter?
Vagnerova K, Liu K, Ardeshiri A, Cheng J, Murphy SJ, Hurn PD, Herson PS
Neuroscience. 2010
PubMed ID: 20035840
Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.
Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ
Int J Cancer. 2010
PubMed ID: 20232390
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T
J Biol Chem. 2010
PubMed ID: 20064938
Genetic Variants of XRCC1, APE1, and ADPRT Genes and Risk of Bladder Cancer.
Wang M, Qin C, Zhu J, Yuan L, Fu G, Zhang Z, Yin C
DNA Cell Biol. 2010
PubMed ID: 20218899
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.
Yang X, Zou P, Yao J, Yun D, Bao H, Du R, Long J, Chen X
J Proteome Res. 2010
PubMed ID: 20000738
Poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites.
Khodyreva SN, Ilina ES, Kutuzov MM, Sukhanova MV, Lavrik OI
Dokl Biochem Biophys. 2010
PubMed ID: 20514865
Mutational analysis of the poly(ADP-ribosyl)ation sites of the transcription factor CTCF provides an insight into the mechanism of its regulation by poly(ADP-ribosyl)ation.
Farrar D, Rai S, Chernukhin I, Jagodic M, Ito Y, Yammine S, Ohlsson R, Murrell A, Klenova E
Mol Cell Biol. 2010
PubMed ID: 20038529
Chromatin repair after oxidative stress: role of PARP-mediated proteasome activation.
Catalgol B, Wendt B, Grimm S, Breusing N, Ozer NK, Grune T
Free Radic Biol Med. 2010
PubMed ID: 20025963
Influence of PARP-1 polymorphisms in patients after traumatic brain injury.
Sarnaik AA, Conley YP, Okonkwo DO, Barr TL, Fink EL, Szabo C, Kochanek PM, Clark RS
J Neurotrauma. 2010
PubMed ID: 19925161
Astrocytic poly(ADP-ribose) polymerase-1 activation leads to bioenergetic depletion and inhibition of glutamate uptake capacity.
Tang KS, Suh SW, Alano CC, Shao Z, Hunt WT, Swanson RA, Anderson CM
Glia. 2010
PubMed ID: 19795500
Poly(ADP-ribose) polymerase 1 regulates activity of DNA polymerase beta in long patch base excision repair.
Sukhanova M, Khodyreva S, Lavrik O
Mutat Res. 2010
PubMed ID: 19703477
In vitro evaluation of pan-PI3-kinase inhibitor SF1126 in trastuzumab-sensitive and trastuzumab-resistant HER2-over-expressing breast cancer cells.
Ozbay T, Durden DL, Liu T, O'Regan RM, Nahta R
Cancer Chemother Pharmacol. 2010
PubMed ID: 19636556
Automodification of PARP-1 mediates its tight binding to the nuclear matrix.
Zaalishvili G, Margiani D, Kutalia K, Suladze S, Zaalishvili T
Biochem Biophys Res Commun. 2010
PubMed ID: 20122899
NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death.
Alano CC, Garnier P, Ying W, Higashi Y, Kauppinen TM, Swanson RA
J Neurosci. 2010
PubMed ID: 20181594
PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity.
Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I
Biochem Biophys Res Commun. 2010
PubMed ID: 20060806
Structural and biophysical studies of human PARP-1 in complex with damaged DNA.
Lilyestrom W, van der Woerd MJ, Clark N, Luger K
J Mol Biol. 2010
PubMed ID: 19962992
ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors.
Williamson CT, Muzik H, Turhan AG, Zamò A, O'Connor MJ, Bebb DG, Lees-Miller SP
Mol Cancer Ther. 2010
PubMed ID: 20124459
Analysis of poly(ADP-ribose) polymerase-1 (PARP1) gene alteration in human germ cell tumor cell lines.
Ogino H, Nakayama R, Sakamoto H, Yoshida T, Sugimura T, Masutani M
Cancer Genet Cytogenet. 2010
PubMed ID: 20113831
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose).
Eustermann S, Brockmann C, Mehrotra PV, Yang JC, Loakes D, West SC, Ahel I, Neuhaus D
Nat Struct Mol Biol. 2010
PubMed ID: 20098424
Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice.
Zhao L, Chen Z, Wang J, Yang L, Zhao Q, Wang J, Qi Q, Mu R, You QD, Guo QL
Cancer Chemother Pharmacol. 2010
PubMed ID: 19585117
Aire's partners in the molecular control of immunological tolerance.
Abramson J, Giraud M, Benoist C, Mathis D
Cell. 2010
PubMed ID: 20085707
PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.
Sahaboglu A, Tanimoto N, Kaur J, Sancho-Pelluz J, Huber G, Fahl E, Arango-Gonzalez B, Zrenner E, Ekström P, Löwenheim H, Seeliger M, Paquet-Durand F
PLoS One. 2010
PubMed ID: 21124852
The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells.
Schult C, Dahlhaus M, Ruck S, Sawitzky M, Amoroso F, Lange S, Etro D, Glass A, Fuellen G, Boldt S, Wolkenhauer O, Neri LM, Freund M, Junghanss C
BMC Cancer. 2010
PubMed ID: 20950443
The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.
Paddock MN, Buelow BD, Takeda S, Scharenberg AM
PLoS Biol. 2010
PubMed ID: 20652015
Comprehensive analysis of the palindromic motif TCTCGCGAGA: a regulatory element of the HNRNPK promoter.
Mikula M, Gaj P, Dzwonek K, Rubel T, Karczmarski J, Paziewska A, Dzwonek A, Bragoszewski P, Dadlez M, Ostrowski J
DNA Res. 2010
PubMed ID: 20587588
Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.
Liu HP, Lin WY, Wu BT, Liu SH, Wang WF, Tsai CH, Lee CC, Tsai FJ
J Clin Lab Anal. 2010
PubMed ID: 20486200
Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.
Prasad P, Tiwari AK, Kumar KM, Ammini AC, Gupta A, Gupta R, Thelma BK
BMC Med Genet. 2010
PubMed ID: 20353610
Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.
Lee CH, Hung HW, Hung PH, Shieh YS
Mol Cancer. 2010
PubMed ID: 20302655
PARP-1 Val762Ala polymorphism is associated with reduced risk of non-Hodgkin lymphoma in Korean males.
Jin XM, Kim HN, Lee IK, Park KS, Kim HJ, Choi JS, Juhng SW, Choi C
BMC Med Genet. 2010
PubMed ID: 20196871
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD
Neuro Oncol. 2010
PubMed ID: 20150366
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.
Lin L, Hutzen B, Li PK, Ball S, Zuo M, DeAngelis S, Foust E, Sobo M, Friedman L, Bhasin D, Cen L, Li C, Lin J
Neoplasia. 2010
PubMed ID: 20072652
Constitutive activation of caspase-3 and Poly ADP ribose polymerase cleavage in fanconi anemia cells.
Lyakhovich A, Surrallés J
Mol Cancer Res. 2010
PubMed ID: 20068062
Brain ischemic preconditioning does not require PARP-1.
Faraco G, Blasi F, Min W, Wang ZQ, Moroni F, Chiarugi A
Stroke. 2010
PubMed ID: 19892992
Inositol hexaphosphate downregulates both constitutive and ligand-induced mitogenic and cell survival signaling, and causes caspase-mediated apoptotic death of human prostate carcinoma PC-3 cells.
Gu M, Raina K, Agarwal C, Agarwal R
Mol Carcinog. 2010
PubMed ID: 19544333
Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1 and DEFA4 in meningococcal disease in three populations.
Emonts M, Vermont CL, Houwing-Duistermaat JJ, Haralambous E, Gaast-de Jongh CE, Hazelzet JA, Faust SN, Betts H, Hermans PW, Levin M, de Groot R, the St Mary's-Imperial college and Erasmus MC-Sophia Children's Hospitals Meningococcal Research Groups
Shock. 2009
PubMed ID: 20016407
Studies of the expression of human poly(ADP-ribose) polymerase-1 in Saccharomyces cerevisiae and identification of PARP-1 substrates by yeast proteome microarray screening.
Tao Z, Gao P, Liu HW
Biochemistry. 2009
PubMed ID: 19877712
Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells.
Frizzell KM, Gamble MJ, Berrocal JG, Zhang T, Krishnakumar R, Cen Y, Sauve AA, Kraus WL
J Biol Chem. 2009
PubMed ID: 19812418
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.
Carboni JM, Wittman M, Yang Z, Lee F, Greer A, Hurlburt W, Hillerman S, Cao C, Cantor GH, Dell-John J, Chen C, Discenza L, Menard K, Li A, Trainor G, Vyas D, Kramer R, Attar RM, Gottardis MM
Mol Cancer Ther. 2009
PubMed ID: 19996272
Doxorubicin-mediated apoptosis in glioma cells requires NFAT3.
Gopinath S, Vanamala SK, Gujrati M, Klopfenstein JD, Dinh DH, Rao JS
Cell Mol Life Sci. 2009
PubMed ID: 19784808
Effects of PARP-1 deficiency on airway inflammatory cell recruitment in response to LPS or TNF: differential effects on CXCR2 ligands and Duffy Antigen Receptor for Chemokines.
Zerfaoui M, Naura AS, Errami Y, Hans CP, Rezk BM, Park J, Elsegeiny W, Kim H, Lord K, Kim JG, Boulares AH
J Leukoc Biol. 2009
PubMed ID: 19741160
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori.
Nossa CW, Jain P, Tamilselvam B, Gupta VR, Chen LF, Schreiber V, Desnoyers S, Blanke SR
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19897724
PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.
Martin N, Schwamborn K, Schreiber V, Werner A, Guillier C, Zhang XD, Bischof O, Seeler JS, Dejean A
EMBO J. 2009
PubMed ID: 19779455
A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation.
Stilmann M, Hinz M, Arslan SC, Zimmer A, Schreiber V, Scheidereit C
Mol Cell. 2009
PubMed ID: 19917246
Mitochondrial localization of PARP-1 requires interaction with mitofilin and is involved in the maintenance of mitochondrial DNA integrity.
Rossi MN, Carbone M, Mostocotto C, Mancone C, Tripodi M, Maione R, Amati P
J Biol Chem. 2009
PubMed ID: 19762472
DNA polymerase beta and PARP activities in base excision repair in living cells.
Masaoka A, Horton JK, Beard WA, Wilson SH
DNA Repair (Amst). 2009
PubMed ID: 19748837
Interaction of DNA topoisomerase 1 with DNA intermediates and proteins of base excision repair.
Lebedeva NA, Rechkunova NI, Agama K, Pommier Y, Lavrik OI
Biochemistry (Mosc). 2009
PubMed ID: 19916945
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease.
Lopez-Escamez JA, Moreno A, Bernal M, Perez-Garrigues H, Santos-Perez S, Soto-Varela A, Aran I, Fernandez-Sanfrancisco O, Lopez-Nevot A, Lopez-Nevot MA
Acta Otolaryngol. 2009
PubMed ID: 19863315
Critical role of poly(ADP-ribose) polymerase-1 in modulating the mode of cell death caused by continuous oxidative stress.
Son YO, Kook SH, Jang YS, Shi X, Lee JC
J Cell Biochem. 2009
PubMed ID: 19711368
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
Harris JL, Jakob B, Taucher-Scholz G, Dianov GL, Becherel OJ, Lavin MF
Hum Mol Genet. 2009
PubMed ID: 19643912
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function.
Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO
FASEB J. 2009
PubMed ID: 19622798
Effect of PARP-1 deficiency on DNA damage and repair in human bronchial epithelial cells exposed to Benzo(a)pyrene.
Tao GH, Yang LQ, Gong CM, Huang HY, Liu JD, Liu JJ, Yuan JH, Chen W, Zhuang ZX
Mol Biol Rep. 2009
PubMed ID: 19247804
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
Crawford NP, Yang H, Mattaini KR, Hunter KW
J Biol Chem. 2009
PubMed ID: 19710015
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.
Riesenberg AN, Liu Z, Kopan R, Brown NL
J Neurosci. 2009
PubMed ID: 19828801
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.
Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS
Cell Stem Cell. 2009
PubMed ID: 19796622
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes.
El Ramy R, Magroun N, Messadecq N, Gauthier LR, Boussin FD, Kolthur-Seetharam U, Schreiber V, McBurney MW, Sassone-Corsi P, Dantzer F
Cell Mol Life Sci. 2009
PubMed ID: 19672559
Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.
Quénet D, Mark M, Govin J, van Dorsselear A, Schreiber V, Khochbin S, Dantzer F
Exp Cell Res. 2009
PubMed ID: 19607827
Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.
Matafora V, D'Amato A, Mori S, Blasi F, Bachi A
Mol Cell Proteomics. 2009
PubMed ID: 19596686
Neuronal caspase-3 and PARP-1 correlate differentially with apoptosis and necrosis in ischemic human stroke.
Sairanen T, Szepesi R, Karjalainen-Lindsberg ML, Saksi J, Paetau A, Lindsberg PJ
Acta Neuropathol. 2009
PubMed ID: 19529948
PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
Selvaraj V, Soundarapandian MM, Chechneva O, Williams AJ, Sidorov MK, Soulika AM, Pleasure DE, Deng W
J Biol Chem. 2009
PubMed ID: 19628872
Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb.
Ohsawa S, Hamada S, Asou H, Kuida K, Uchiyama Y, Yoshida H, Miura M
J Neurosci. 2009
PubMed ID: 19741144
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ
Science. 2009
PubMed ID: 19661379
Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.
Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL
Nat Immunol. 2009
PubMed ID: 19684606
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation.
Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG
Nat Struct Mol Biol. 2009
PubMed ID: 19680243
Scarless fetal mouse wound healing may initiate apoptosis through caspase 7 and cleavage of PARP.
Carter R, Sykes V, Lanning D
J Surg Res. 2009
PubMed ID: 19555972
Promising molecular targets in ovarian cancer.
Blagden S, Gabra H
Curr Opin Oncol. 2009
PubMed ID: 19553815
Interaction of Sindbis virus non-structural protein 3 with poly(ADP-ribose) polymerase 1 in neuronal cells.
Park E, Griffin DE
J Gen Virol. 2009
PubMed ID: 19515826
Effect of poly (ADP-ribose) polymerase-1 inhibition on the proliferation of murine colon carcinoma CT26 cells.
Cai L, Threadgill MD, Wang Y, Li M
Pathol Oncol Res. 2009
PubMed ID: 18989759
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666485
Regulation of rat haptoglobin gene expression is coordinated by the nuclear matrix.
Vidaković M, Dinić S, Grdović N, Mihailović M, Uskoković A, Quesada P, Poznanović G
J Cell Biochem. 2009
PubMed ID: 19521970
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation.
Gao F, Kwon SW, Zhao Y, Jin Y
J Biol Chem. 2009
PubMed ID: 19531481
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.
Zhu P, Martinvalet D, Chowdhury D, Zhang D, Schlesinger A, Lieberman J
Blood. 2009
PubMed ID: 19506301
Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis.
Perdoni F, Bottone MG, Soldani C, Veneroni P, Alpini C, Pellicciari C, Scovassi AI
Ann N Y Acad Sci. 2009
PubMed ID: 19723035
The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ
Nat Neurosci. 2009
PubMed ID: 19633665
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.
Rajamohan SB, Pillai VB, Gupta M, Sundaresan NR, Birukov KG, Samant S, Hottiger MO, Gupta MP
Mol Cell Biol. 2009
PubMed ID: 19470756
PARP inhibition delays transition of hypertensive cardiopathy to heart failure in spontaneously hypertensive rats.
Bartha E, Solti I, Kereskai L, Lantos J, Plozer E, Magyar K, Szabados E, Kálai T, Hideg K, Halmosi R, Sumegi B, Toth K
Cardiovasc Res. 2009
PubMed ID: 19443425
Calcium dysregulation induces apoptosis-inducing factor release: cross-talk between PARP-1- and calpain-signaling pathways.
Vosler PS, Sun D, Wang S, Gao Y, Kintner DB, Signore AP, Cao G, Chen J
Exp Neurol. 2009
PubMed ID: 19427306
Role of PARP-1 and PARP-2 in the expression of apoptosis-regulating genes in HeLa cells.
Cohausz O, Althaus FR
Cell Biol Toxicol. 2009
PubMed ID: 18587655
Positive transcriptional regulation of the human micro opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 -> T.
Ono T, Kaneda T, Muto A, Yoshida T
J Biol Chem. 2009
PubMed ID: 19447888
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Poly(ADP-ribose) polymerase-1 polymorphisms, expression and activity in selected human tumour cell lines.
Zaremba T, Ketzer P, Cole M, Coulthard S, Plummer ER, Curtin NJ
Br J Cancer. 2009
PubMed ID: 19568233
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.
Yang F, Baumann C, De La Fuente R
Dev Biol. 2009
PubMed ID: 19463809
Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Hoskins JM, Rosner GL, Ratain MJ, McLeod HL, Innocenti F
Pharmacogenomics. 2009
PubMed ID: 19604089
Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis.
Luo P, Lin M, Lin M, Chen Y, Yang B, He Q
Leuk Lymphoma. 2009
PubMed ID: 19557639
gammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids.
Qvarnström OF, Simonsson M, Eriksson V, Turesson I, Carlsson J
Int J Oncol. 2009
PubMed ID: 19513550
PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases.
Peralta-Leal A, Rodríguez-Vargas JM, Aguilar-Quesada R, Rodríguez MI, Linares JL, de Almodóvar MR, Oliver FJ
Free Radic Biol Med. 2009
PubMed ID: 19362586
Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice.
Meyer-Ficca ML, Lonchar J, Credidio C, Ihara M, Li Y, Wang ZQ, Meyer RG
Biol Reprod. 2009
PubMed ID: 19264700
Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes.
Reinemund J, Seidel K, Steckelings UM, Zaade D, Klare S, Rompe F, Katerbaum M, Schacherl J, Li Y, Menk M, Schefe JH, Goldin-Lang P, Szabo C, Olah G, Unger T, Funke-Kaiser H
Biochem Pharmacol. 2009
PubMed ID: 19344625
Poly(ADP-ribose) polymerase-1 regulates the progression of autoimmune nephritis in males by inducing necrotic cell death and modulating inflammation.
Jog NR, Dinnall JA, Gallucci S, Madaio MP, Caricchio R
J Immunol. 2009
PubMed ID: 19454727
Differential PARP cleavage: an indication of heterogeneous forms of cell death and involvement of multiple proteases in the infarct of focal cerebral ischemia in rat.
Chaitanya GV, Babu PP
Cell Mol Neurobiol. 2009
PubMed ID: 19225880
Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses.
Ambrose HE, Willimott S, Beswick RW, Dantzer F, de Murcia JM, Yelamos J, Wagner SD
Immunology. 2009
PubMed ID: 18778284
PARP-1 expression in the mouse is controlled by an autoregulatory loop: PARP-1 binding to an upstream S/MAR element and to a novel recognition motif in its promoter suppresses transcription.
Vidaković M, Gluch A, Qiao J, Oumard A, Frisch M, Poznanović G, Bode J
J Mol Biol. 2009
PubMed ID: 19303024
Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age.
Shibata A, Maeda D, Ogino H, Tsutsumi M, Nohmi T, Nakagama H, Sugimura T, Teraoka H, Masutani M
Mutat Res. 2009
PubMed ID: 19428377
Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.
Robert I, Dantzer F, Reina-San-Martin B
J Exp Med. 2009
PubMed ID: 19364882
Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1.
Sakamaki J, Daitoku H, Yoshimochi K, Miwa M, Fukamizu A
Biochem Biophys Res Commun. 2009
PubMed ID: 19281796
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
The Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population.
Tezcan G, Gurel CB, Tutluoglu B, Onaran I, Kanigur-Sultuybek G
J Asthma. 2009
PubMed ID: 19484672
Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells.
Li M, Threadgill MD, Wang Y, Cai L, Lin X
Pathobiology. 2009
PubMed ID: 19468250
Micronucleus occurrence related to base excision repair gene polymorphisms in Chinese workers occupationally exposed to vinyl chloride monomer.
Wen-Bin M, Wei W, Yu-Lan Q, Fang J, Zhao-Lin X
J Occup Environ Med. 2009
PubMed ID: 19369898
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
A caveat in mouse genetic engineering: ectopic gene targeting in ES cells by bidirectional extension of the homology arms of a gene replacement vector carrying human PARP-1.
Mangerich A, Scherthan H, Diefenbach J, Kloz U, van der Hoeven F, Beneke S, Bürkle A
Transgenic Res. 2009
PubMed ID: 19034683
Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.
Hossain MB, Ji P, Anish R, Jacobson RH, Takada S
J Biol Chem. 2009
PubMed ID: 19181665
A role of DNA-PK for the metabolic gene regulation in response to insulin.
Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS
Cell. 2009
PubMed ID: 19303849
Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage.
Ding W, Liu W, Cooper KL, Qin XJ, de Souza Bergo PL, Hudson LG, Liu KJ
J Biol Chem. 2009
PubMed ID: 19056730
Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population.
Li WQ, Zhang L, Ma JL, Zhang Y, Li JY, Pan KF, You WC
Carcinogenesis. 2009
PubMed ID: 19147860
Delocalization of nucleolar poly(ADP-ribose) polymerase-1 to the nucleoplasm and its novel link to cellular sensitivity to DNA damage.
Rancourt A, Satoh MS
DNA Repair (Amst). 2009
PubMed ID: 19144573
Poly(adenosine diphosphate-ribose) polymerase-1 expression in cutaneous malignant melanomas as a new molecular marker of aggressive tumor.
Csete B, Lengyel Z, Kádár Z, Battyáni Z
Pathol Oncol Res. 2009
PubMed ID: 18752052
Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.
Jha R, Agarwal A, Mahfouz R, Paasch U, Grunewald S, Sabanegh E, Yadav SP, Sharma R
Fertil Steril. 2009
PubMed ID: 18339380
Ionizing radiation-induced NF-kappaB activation requires PARP-1 function to confer radioresistance.
Veuger SJ, Hunter JE, Durkacz BW
Oncogene. 2009
PubMed ID: 19060926
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De Smedt T, Leo O
Nat Med. 2009
PubMed ID: 19151729
To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage.
Huang Q, Shen HM
Autophagy. 2009
PubMed ID: 19139632
Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia.
Naura AS, Datta R, Hans CP, Zerfaoui M, Rezk BM, Errami Y, Oumouna M, Matrougui K, Boulares AH
Eur Respir J. 2009
PubMed ID: 18829681
Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis.
Taniguchi N, Caramés B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, Lotz M
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19139395
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.
Vineis P, Manuguerra M, Kavvoura FK, Guarrera S, Allione A, Rosa F, Di Gregorio A, Polidoro S, Saletta F, Ioannidis JP, Matullo G
J Natl Cancer Inst. 2009
PubMed ID: 19116388
Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese Health Study.
Stern MC, Butler LM, Corral R, Joshi AD, Yuan JM, Koh WP, Yu MC
J Nutrigenet Nutrigenomics. 2009
PubMed ID: 20559012
Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.
Agarwal A, Mahfouz RZ, Sharma RK, Sarkar O, Mangrola D, Mathur PP
Reprod Biol Endocrinol. 2009
PubMed ID: 19961617
Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress.
Hans CP, Feng Y, Naura AS, Zerfaoui M, Rezk BM, Xia H, Kaye AD, Matrougui K, Lazartigues E, Boulares AH
PLoS One. 2009
PubMed ID: 19823587
Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway.
Adamczyk A, Kaźmierczak A
Folia Neuropathol. 2009
PubMed ID: 19813144
Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation.
O'Valle F, Del Moral RG, Benítez Mdel C, Martín-Oliva D, Gómez-Morales M, Aguilar D, Aneiros-Fernández J, Hernández-Cortés P, Osuna A, Moreso F, Serón D, Oliver FJ, Del Moral RG
PLoS One. 2009
PubMed ID: 19784367
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners.
Montes de Oca R, Shoemaker CJ, Gucek M, Cole RN, Wilson KL
PLoS One. 2009
PubMed ID: 19759913
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
The augmented anti-tumor effects of Antrodia camphorata co-fermented with Chinese medicinal herb in human hepatoma cells.
Li SL, Huang ZN, Hsieh HH, Yu WC, Tzeng WY, Lee GY, Chen YP, Chang CY, Chuu JJ
Am J Chin Med. 2009
PubMed ID: 19655414
Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis.
Lisa A, Monti D, Franceschi C, Scovassi AI
Gerontology. 2009
PubMed ID: 19372636
Adenovirus-mediated thymidine kinase gene therapy induces apoptosis in human epithelial ovarian cancer cells and damages PARP-1.
Kieback DG
In Vivo. 2009
PubMed ID: 19368128
Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase.
Burns DM, Ying W, Kauppinen TM, Zhu K, Swanson RA
PLoS One. 2009
PubMed ID: 19319190
Parp1 localizes within the Dnmt1 promoter and protects its unmethylated state by its enzymatic activity.
Zampieri M, Passananti C, Calabrese R, Perilli M, Corbi N, De Cave F, Guastafierro T, Bacalini MG, Reale A, Amicosante G, Calabrese L, Zlatanova J, Caiafa P
PLoS One. 2009
PubMed ID: 19262751
Association and interactions between DNA repair gene polymorphisms and adult glioma.
Liu Y, Scheurer ME, El-Zein R, Cao Y, Do KA, Gilbert M, Aldape KD, Wei Q, Etzel C, Bondy ML
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124499
Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology.
Jiang J, Zhang X, Yang H, Wang W
Methods Mol Biol. 2009
PubMed ID: 19109787
Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment.
Moroni F, Chiarugi A
FEBS J. 2009
PubMed ID: 19087198
PARP-1 inhibits glycolysis in ischemic kidneys.
Devalaraja-Narashimha K, Padanilam BJ
J Am Soc Nephrol. 2009
PubMed ID: 19056868
Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry CP, Seldin MF, Kelsey KT, Wiencke JK
Carcinogenesis. 2009
PubMed ID: 19029194
Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer.
Wang SS, Bratti MC, Rodríguez AC, Herrero R, Burk RD, Porras C, González P, Sherman ME, Wacholder S, Lan ZE, Schiffman M, Chanock SJ, Hildesheim A
J Infect Dis. 2009
PubMed ID: 19012493
PARP-1 is involved in autophagy induced by DNA damage.
Muñoz-Gámez JA, Rodríguez-Vargas JM, Quiles-Pérez R, Aguilar-Quesada R, Martín-Oliva D, de Murcia G, Menissier de Murcia J, Almendros A, Ruiz de Almodóvar M, Oliver FJ
Autophagy. 2009
PubMed ID: 19001878
PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts.
Huang D, Yang C, Wang Y, Liao Y, Huang K
Cardiovasc Res. 2009
PubMed ID: 18815186
Induction of apoptosis by the inhibitors of poly(ADP-ribose)polymerase in HeLa cells.
Ghosh U, Bhattacharyya NP
Mol Cell Biochem. 2009
PubMed ID: 18695944
PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA.
Sugimura K, Takebayashi S, Taguchi H, Takeda S, Okumura K
J Cell Biol. 2008
PubMed ID: 19103807
Poly(ADP-ribose) polymerase-1 down-regulates BRCA2 expression through the BRCA2 promoter.
Wang J, Bian C, Li J, Couch FJ, Wu K, Zhao RC
J Biol Chem. 2008
PubMed ID: 18990703
Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.
Shi L, Ko S, Kim S, Echchgadda I, Oh TS, Song CS, Chatterjee B
J Biol Chem. 2008
PubMed ID: 18945670
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
Enjuanes A, Benavente Y, Bosch F, Martín-Guerrero I, Colomer D, Pérez-Alvarez S, Reina O, Ardanaz MT, Jares P, García-Orad A, Pujana MA, Montserrat E, de Sanjosé S, Campo E
Cancer Res. 2008
PubMed ID: 19074885
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1.
Choi HS, Hwang CK, Kim CS, Song KY, Law PY, Loh HH, Wei LN
J Cell Mol Med. 2008
PubMed ID: 18266974
The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.
Onaran I, Tezcan G, Ozgönenel L, Cetin E, Ozdemir AT, Kanıgür-Sultuybek G
Rheumatol Int. 2008
PubMed ID: 19030862
Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential.
Dungey FA, Löser DA, Chalmers AJ
Int J Radiat Oncol Biol Phys. 2008
PubMed ID: 18954712
Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.
Huang D, Yang CZ, Yao L, Wang Y, Liao YH, Huang K
Arch Med Res. 2008
PubMed ID: 18996291
Poly(ADP-ribose) polymerase 1 binds to Pax8 and inhibits its transcriptional activity.
Di Palma T, de Cristofaro T, D'Ambrosio C, Del Prete D, Scaloni A, Zannini M
J Mol Endocrinol. 2008
PubMed ID: 18768662
Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition.
Kedar PS, Stefanick DF, Horton JK, Wilson SH
DNA Repair (Amst). 2008
PubMed ID: 18691676
Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.
Chiu HJ, Fischman DA, Hammerling U
FASEB J. 2008
PubMed ID: 18676402
The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha.
Quénet D, Gasser V, Fouillen L, Cammas F, Sanglier-Cianferani S, Losson R, Dantzer F
FASEB J. 2008
PubMed ID: 18676401
Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection.
Lee JY, Kim YJ, Kim TY, Koh JY, Kim YH
J Neurosci. 2008
PubMed ID: 18945899
Poly(ADP-ribosyl)ation is implicated in the G0-G1 transition of resting cells.
Carbone M, Rossi MN, Cavaldesi M, Notari A, Amati P, Maione R
Oncogene. 2008
PubMed ID: 18663363
The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation.
Sala A, La Rocca G, Burgio G, Kotova E, Di Gesù D, Collesano M, Ingrassia AM, Tulin AV, Corona DF
PLoS Biol. 2008
PubMed ID: 18922045
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Integrin-linked kinase regulates E-cadherin expression through PARP-1.
McPhee TR, McDonald PC, Oloumi A, Dedhar S
Dev Dyn. 2008
PubMed ID: 18773488
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.
Tanori M, Mancuso M, Pasquali E, Leonardi S, Rebessi S, Di Majo V, Guilly MN, Giangaspero F, Covelli V, Pazzaglia S, Saran A
Carcinogenesis. 2008
PubMed ID: 18660545
Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.
Qin XJ, Hudson LG, Liu W, Timmins GS, Liu KJ
Toxicol Appl Pharmacol. 2008
PubMed ID: 18619636
Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma.
Chiang FY, Wu CW, Hsiao PJ, Kuo WR, Lee KW, Lin JC, Liao YC, Juo SH
Clin Cancer Res. 2008
PubMed ID: 18779313
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.
Buelow B, Song Y, Scharenberg AM
J Biol Chem. 2008
PubMed ID: 18599483
PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells.
Huang SH, Xiong M, Chen XP, Xiao ZY, Zhao YF, Huang ZY
Oncol Rep. 2008
PubMed ID: 18695907
PARP mediates structural alterations in diabetic cardiomyopathy.
Chiu J, Farhangkhoee H, Xu BY, Chen S, George B, Chakrabarti S
J Mol Cell Cardiol. 2008
PubMed ID: 18657544
Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury.
Fink EL, Lai Y, Zhang X, Janesko-Feldman K, Adelson PD, Szabó C, Berger RP, Sarnaik AA, Kochanek PM, Clark RS
J Cereb Blood Flow Metab. 2008
PubMed ID: 18506195
PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population.
Zhang Q, Li Y, Li X, Zhou W, Shi B, Chen H, Yuan W
Mol Biol Rep. 2008
PubMed ID: 18716896
PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress.
Martínez-Romero R, Martínez-Lara E, Aguilar-Quesada R, Peralta A, Oliver FJ, Siles E
J Cell Biochem. 2008
PubMed ID: 18459142
CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery.
Guastafierro T, Cecchinelli B, Zampieri M, Reale A, Riggio G, Sthandier O, Zupi G, Calabrese L, Caiafa P
J Biol Chem. 2008
PubMed ID: 18539602
Dependence of trans-ADP-ribosylation and nuclear glycolysis on the Arg 34-ATP complex of Zn2+ finger I of poly-ADP-ribose polymerase-1.
Kun E, Kirsten E, Hakam A, Bauer PI, Mendeleyev J
FEBS Lett. 2008
PubMed ID: 18619441
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation.
Song ZF, Ji XP, Li XX, Wang SJ, Wang SH, Zhang Y
J Cell Mol Med. 2008
PubMed ID: 18782186
The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia.
Tapia-Páez I, Tammimies K, Massinen S, Roy AL, Kere J
FASEB J. 2008
PubMed ID: 18445785
A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.
Lin CP, Ban Y, Lyu YL, Desai SD, Liu LF
J Biol Chem. 2008
PubMed ID: 18515798
Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation.
Phulwani NK, Kielian T
J Neurochem. 2008
PubMed ID: 18410506
PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.
Xu B, Chiu J, Feng B, Chen S, Chakrabarti S
Diabetes Metab Res Rev. 2008
PubMed ID: 18351623
Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications.
Chiu J, Xu BY, Chen S, Feng B, Chakrabarti S
Can J Physiol Pharmacol. 2008
PubMed ID: 18516100
Stable depletion of poly (ADP-ribose) polymerase-1 reduces in vivo melanoma growth and increases chemosensitivity.
Tentori L, Muzi A, Dorio AS, Bultrini S, Mazzon E, Lacal PM, Shah GM, Zhang J, Navarra P, Nocentini G, Cuzzocrea S, Graziani G
Eur J Cancer. 2008
PubMed ID: 18440222
Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage.
Liu X, Luo X, Shi Y, Zhu GD, Penning T, Giranda VL, Luo Y
Cancer Biol Ther. 2008
PubMed ID: 18376143
Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.
Hans CP, Zerfaoui M, Naura AS, Catling A, Boulares AH
Cardiovasc Res. 2008
PubMed ID: 18245064
Induction of cytogenetic adaptive response in spermatogonia and spermatocytes by pre-exposure of mouse testis to low-dose (12)C(6+) ions.
Zhang H, Zhao W, Wang Y, Li N, Wu Z, Liu Y, Chen J, Cai Y
Mutat Res. 2008
PubMed ID: 18490192
Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif.
Tao Z, Gao P, Hoffman DW, Liu HW
Biochemistry. 2008
PubMed ID: 18452307
Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway.
Audebert M, Salles B, Calsou P
Biochem Biophys Res Commun. 2008
PubMed ID: 18054777
Upregulation of PEDF expression by PARP inhibition contributes to the decrease in hyperglycemia-induced apoptosis in HUVECs.
Chen H, Jia W, Xu X, Fan Y, Zhu D, Wu H, Xie Z, Zheng Z
Biochem Biophys Res Commun. 2008
PubMed ID: 18312852
Ethnic disparities in Americans of European descent versus Americans of African descent related to polymorphic ERCC1, ERCC2, XRCC1, and PARP1.
Gao R, Price DK, Sissung T, Reed E, Figg WD
Mol Cancer Ther. 2008
PubMed ID: 18483312
Repair of radiation-induced heat-labile sites is independent of DNA-PKcs, XRCC1 and PARP.
Karlsson KH, Radulescu I, Rydberg B, Stenerlöw B
Radiat Res. 2008
PubMed ID: 18439038
Regulation of transcription factor NFAT by ADP-ribosylation.
Olabisi OA, Soto-Nieves N, Nieves E, Yang TT, Yang X, Yu RY, Suk HY, Macian F, Chow CW
Mol Cell Biol. 2008
PubMed ID: 18299389
Poly(ADP-ribose) polymerase-1 enhances transcription of the profibrotic CCN2 gene.
Okada H, Inoue T, Kikuta T, Kato N, Kanno Y, Hirosawa N, Sakamoto Y, Sugaya T, Suzuki H
J Am Soc Nephrol. 2008
PubMed ID: 18287562
Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD+, and dipeptides.
Wang T, Simbulan-Rosenthal CM, Smulson ME, Chock PB, Yang DC
J Cell Biochem. 2008
PubMed ID: 18041763
First evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1.
Soldatenkov VA, Vetcher AA, Duka T, Ladame S
ACS Chem Biol. 2008
PubMed ID: 18338862
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.
Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W
Mol Cell. 2008
PubMed ID: 18406329
Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.
Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson EM, Brock HW, An W
J Biol Chem. 2008
PubMed ID: 18258596
p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells.
Lee HI, Jang SY, Kang HT, Hwang ES
Biochem Biophys Res Commun. 2008
PubMed ID: 18230337
Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.
Louro H, Pinheiro I, Costa P, Sousa C, Dias A, Boavida MG, Silva MJ
Mutat Res. 2008
PubMed ID: 18242645
Transient inhibition of poly(ADP-ribose) polymerase expression and activity by Toxoplasma gondii is dispensable for parasite-mediated blockade of host cell apoptosis and intracellular parasite replication.
Gais A, Beinert N, Gross U, Lüder CG
Microbes Infect. 2008
PubMed ID: 18396434
Prevalence of BER gene polymorphisms in sporadic breast cancer.
Ali MF, Meza JL, Rogan EG, Chakravarti D
Oncol Rep. 2008
PubMed ID: 18357393
Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.
Jarjanazi H, Kiefer J, Savas S, Briollais L, Tuzmen S, Pabalan N, Ibrahim-Zada I, Mousses S, Ozcelik H
Hum Mutat. 2008
PubMed ID: 18330920
PARP1 is required for adhesion molecule expression in atherogenesis.
von Lukowicz T, Hassa PO, Lohmann C, Borén J, Braunersreuther V, Mach F, Odermatt B, Gersbach M, Camici GG, Stähli BE, Tanner FC, Hottiger MO, Lüscher TF, Matter CM
Cardiovasc Res. 2008
PubMed ID: 18093987
Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.
Valdor R, Schreiber V, Saenz L, Martínez T, Muñoz-Suano A, Dominguez-Villar M, Ramírez P, Parrilla P, Aguado E, García-Cózar F, Yélamos J
Mol Immunol. 2008
PubMed ID: 18078995
Poly(adp-ribose) polymerase-1 regulates Tracp gene promoter activity during RANKL-induced osteoclastogenesis.
Beranger GE, Momier D, Rochet N, Carle GF, Scimeca JC
J Bone Miner Res. 2008
PubMed ID: 18021007
Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1.
Hassa PO, Covic M, Bedford MT, Hottiger MO
J Mol Biol. 2008
PubMed ID: 18280497
Irinotecan pharmacogenetics: influence of pharmacodynamic genes.
Hoskins JM, Marcuello E, Altes A, Marsh S, Maxwell T, Van Booven DJ, Paré L, Culverhouse R, McLeod HL, Baiget M
Clin Cancer Res. 2008
PubMed ID: 18347181
PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy.
Obrosova IG, Xu W, Lyzogubov VV, Ilnytska O, Mashtalir N, Vareniuk I, Pavlov IA, Zhang J, Slusher B, Drel VR
Free Radic Biol Med. 2008
PubMed ID: 17976390
Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury.
Lai Y, Chen Y, Watkins SC, Nathaniel PD, Guo F, Kochanek PM, Jenkins LW, Szabó C, Clark RS
J Neurochem. 2008
PubMed ID: 17996029
A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation.
Langelier MF, Servent KM, Rogers EE, Pascal JM
J Biol Chem. 2008
PubMed ID: 18055453
Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.
Krishnakumar R, Gamble MJ, Frizzell KM, Berrocal JG, Kininis M, Kraus WL
Science. 2008
PubMed ID: 18258916
Identification of poly(ADP-ribose) polymerase-1 as the OXPHOS-generated ATP sensor of nuclei of animal cells.
Kun E, Kirsten E, Hakam A, Bauer PI, Mendeleyev J
Biochem Biophys Res Commun. 2008
PubMed ID: 18073140
Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression.
Elser M, Borsig L, Hassa PO, Erener S, Messner S, Valovka T, Keller S, Gassmann M, Hottiger MO
Mol Cancer Res. 2008
PubMed ID: 18314489
[Expression and implication of base excision repair genes in human nasopharyngeal carcinoma and non-tumor nasopharyngeal tissues]
Liu N, Zhou XX, Lu LX
Ai Zheng. 2008
PubMed ID: 18279607
Resveratrol-induced apoptosis in human breast cancer cells is mediated primarily through the caspase-3-dependent pathway.
Alkhalaf M, El-Mowafy A, Renno W, Rachid O, Ali A, Al-Attyiah R
Arch Med Res. 2008
PubMed ID: 18164959
Hippocampal poly(ADP-Ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection.
Williams BL, Hornig M, Yaddanapudi K, Lipkin WI
J Virol. 2008
PubMed ID: 18057239
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.
Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D
Mol Cell. 2008
PubMed ID: 18206965
Treatment with insulin inhibits poly(ADP-ribose)polymerase activation in a rat model of endotoxemia.
Horváth EM, Benko R, Gero D, Kiss L, Szabó C
Life Sci. 2008
PubMed ID: 18078960
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites.
Haince JF, McDonald D, Rodrigue A, Déry U, Masson JY, Hendzel MJ, Poirier GG
J Biol Chem. 2008
PubMed ID: 18025084
Oxidative-induced apoptosis to an immortalized ganglion cell line is caspase independent but involves the activation of poly(ADP-ribose)polymerase and apoptosis-inducing factor.
Li GY, Osborne NN
Brain Res. 2008
PubMed ID: 18053973
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins.
Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC
Nature. 2008
PubMed ID: 18172500
Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury.
Kim JH, Suk MH, Yoon DW, Kim HY, Jung KH, Kang EH, Lee SY, Lee SY, Suh IB, Shin C, Shim JJ, In KH, Yoo SH, Kang KH
Crit Care. 2008
PubMed ID: 18718025
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
PLoS ONE. 2008
PubMed ID: 18636124
Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation.
Saenz L, Lozano JJ, Valdor R, Baroja-Mazo A, Ramirez P, Parrilla P, Aparicio P, Sumoy L, Yélamos J
BMC Genomics. 2008
PubMed ID: 18412984
The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.
Hakmé A, Huber A, Dollé P, Schreiber V
Dev Dyn. 2008
PubMed ID: 18069692
Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction.
Zerfaoui M, Suzuki Y, Naura AS, Hans CP, Nichols C, Boulares AH
Cell Signal. 2008
PubMed ID: 17993261
Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity.
Duan Y, Gross RA, Sheu SS
J Physiol. 2007
PubMed ID: 17947304
Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.
Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TF, Guse AH, Lund FE
J Immunol. 2007
PubMed ID: 18025229
AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.
Jane EP, Premkumar DR, Pollack IF
Cancer Lett. 2007
PubMed ID: 17900801
DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study.
Stern MC, Conti DV, Siegmund KD, Corral R, Yuan JM, Koh WP, Yu MC
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 18006925
Targeting poly(ADP-ribose) polymerase: a two-armed strategy for cancer therapy.
Plummer ER, Calvert H
Clin Cancer Res. 2007
PubMed ID: 17975135
The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription.
Wacker DA, Ruhl DD, Balagamwala EH, Hope KM, Zhang T, Kraus WL
Mol Cell Biol. 2007
PubMed ID: 17785446
Differential contribution of poly(ADP-ribose)polymerase-1 and -2 (PARP-1 and -2) to the poly(ADP-ribosyl)ation reaction in rat primary spermatocytes.
Tramontano F, Malanga M, Quesada P
Mol Hum Reprod. 2007
PubMed ID: 17766683
Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis media.
Emonts M, Veenhoven RH, Wiertsema SP, Houwing-Duistermaat JJ, Walraven V, de Groot R, Hermans PW, Sanders EA
Pediatrics. 2007
PubMed ID: 17908769
Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
Geraets L, Moonen HJ, Brauers K, Wouters EF, Bast A, Hageman GJ
J Nutr. 2007
PubMed ID: 17884996
TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.
Pungaliya P, Kulkarni D, Park HJ, Marshall H, Zheng H, Lackland H, Saleem A, Rubin EH
J Proteome Res. 2007
PubMed ID: 17803295
Differential expression in lupus-associated IL-10 promoter single-nucleotide polymorphisms is mediated by poly(ADP-ribose) polymerase-1.
Chung EY, Liu J, Zhang Y, Ma X
Genes Immun. 2007
PubMed ID: 17703177
Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.
Pottier N, Cheok MH, Yang W, Assem M, Tracey L, Obenauer JC, Panetta JC, Relling MV, Evans WE
Hum Mol Genet. 2007
PubMed ID: 17616514
Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse.
Paquet-Durand F, Silva J, Talukdar T, Johnson LE, Azadi S, van Veen T, Ueffing M, Hauck SM, Ekström PA
J Neurosci. 2007
PubMed ID: 17881537
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Poly(ADP-ribose) polymerase expression in kidney transplantation: from alfa (alpha) to Omega (Omega).
O'Valle F, Gómez-Morales M, Del Moral RM, Serón D, Moreso F, Osuna A, Oliver FJ, Del Moral RG
Transplant Proc. 2007
PubMed ID: 17889105
Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis.
Tentori L, Lacal PM, Muzi A, Dorio AS, Leonetti C, Scarsella M, Ruffini F, Xu W, Min W, Stoppacciaro A, Colarossi C, Wang ZQ, Zhang J, Graziani G
Eur J Cancer. 2007
PubMed ID: 17714938
Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status.
Szijártó A, Batmunkh E, Hahn O, Mihály Z, Kreiss A, Kiss A, Lotz G, Schaff Z, Váli L, Blázovics A, Geró D, Szabó C, Kupcsulik P
J Surg Res. 2007
PubMed ID: 17612561
Poly(ADP-ribose) polymerase-1 (PARP-1) controls lung cell proliferation and repair after hyperoxia-induced lung damage.
Pagano A, Métrailler-Ruchonnet I, Aurrand-Lions M, Lucattelli M, Donati Y, Argiroffo CB
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17575013
p27kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice.
Rajareddy S, Reddy P, Du C, Liu L, Jagarlamudi K, Tang W, Shen Y, Berthet C, Peng SL, Kaldis P, Liu K
Mol Endocrinol. 2007
PubMed ID: 17565040
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients.
Cao WH, Wang X, Frappart L, Rigal D, Wang ZQ, Shen Y, Tong WM
Mutat Res. 2007
PubMed ID: 17560163
Radiation-induced PARP activation is enhanced through EGFR-ERK signaling.
Hagan MP, Yacoub A, Dent P
J Cell Biochem. 2007
PubMed ID: 17295209
Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain.
Poitras MF, Koh DW, Yu SW, Andrabi SA, Mandir AS, Poirier GG, Dawson VL, Dawson TM
Neuroscience. 2007
PubMed ID: 17640816
Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling.
Wang SJ, Wang SH, Song ZF, Liu XW, Wang R, Chi ZF
Neuroreport. 2007
PubMed ID: 17632284
Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication.
Kanai M, Tong WM, Wang ZQ, Miwa M
Biochem Biophys Res Commun. 2007
PubMed ID: 17553458
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.
Fisher AE, Hochegger H, Takeda S, Caldecott KW
Mol Cell Biol. 2007
PubMed ID: 17548475
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis.
Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J, Susin SA
Mol Cell Biol. 2007
PubMed ID: 17470554
Differential binding of poly(ADP-Ribose) polymerase-1 and JunD/Fra2 accounts for RANKL-induced Tcirg1 gene expression during osteoclastogenesis.
Beranger GE, Momier D, Guigonis JM, Samson M, Carle GF, Scimeca JC
J Bone Miner Res. 2007
PubMed ID: 17419679
Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus.
Ditsworth D, Zong WX, Thompson CB
J Biol Chem. 2007
PubMed ID: 17430886
[Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29]
Hao LX, Wang YL, Cai L, Li YY
Ai Zheng. 2007
PubMed ID: 17562258
SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery.
Gamble MJ, Fisher RP
Nat Struct Mol Biol. 2007
PubMed ID: 17529993
Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians.
Chevanne M, Calia C, Zampieri M, Cecchinelli B, Caldini R, Monti D, Bucci L, Franceschi C, Caiafa P
Rejuvenation Res. 2007
PubMed ID: 17518695
Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.
Haince JF, Kozlov S, Dawson VL, Dawson TM, Hendzel MJ, Lavin MF, Poirier GG
J Biol Chem. 2007
PubMed ID: 17428792
Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1.
Selle A, Ullrich O, Harnacke K, Hass R
Exp Gerontol. 2007
PubMed ID: 17314023
Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.
Tong WM, Yang YG, Cao WH, Galendo D, Frappart L, Shen Y, Wang ZQ
Oncogene. 2007
PubMed ID: 17160013
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332
Isolation and characterization of proteins associated with histone H3 tails in vivo.
Heo K, Kim B, Kim K, Choi J, Kim H, Zhan Y, Ranish JA, An W
J Biol Chem. 2007
PubMed ID: 17403666
Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease.
Infante J, Sánchez-Juan P, Mateo I, Rodríguez-Rodríguez E, Sánchez-Quintana C, Llorca J, Fontalba A, Terrazas J, Oterino A, Berciano J, Combarros O
J Neurol Sci. 2007
PubMed ID: 17362997
Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.
Oumouna-Benachour K, Hans CP, Suzuki Y, Naura A, Datta R, Belmadani S, Fallon K, Woods C, Boulares AH
Circulation. 2007
PubMed ID: 17438151
Prolonged poly(ADP-ribose) polymerase-1 activity regulates JP-8-induced sustained cytokine expression in alveolar macrophages.
Espinoza LA, Smulson ME, Chen Z
Free Radic Biol Med. 2007
PubMed ID: 17395016
Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.
Wang X, Liu L, Montagna C, Ried T, Deng CX
Cell Death Differ. 2007
PubMed ID: 17318223
c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation.
Zhang S, Lin Y, Kim YS, Hande MP, Liu ZG, Shen HM
Cell Death Differ. 2007
PubMed ID: 17218956
Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome.
Nusinow DA, Hernández-Muñoz I, Fazzio TG, Shah GM, Kraus WL, Panning B
J Biol Chem. 2007
PubMed ID: 17322296
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
Kanno S, Kuzuoka H, Sasao S, Hong Z, Lan L, Nakajima S, Yasui A
EMBO J. 2007
PubMed ID: 17396150
Poly(adenosine diphosphate-ribose) polymerase expression in serous ovarian carcinoma: correlation with p53, MIB-1, and outcome.
Brustmann H
Int J Gynecol Pathol. 2007
PubMed ID: 17413981
Genetic variation in the base excision repair pathway and bladder cancer risk.
Figueroa JD, Malats N, Real FX, Silverman D, Kogevinas M, Chanock S, Welch R, Dosemeci M, Tardón A, Serra C, Carrato A, García-Closas R, Castaño-Vinyals G, Rothman N, García-Closas M
Hum Genet. 2007
PubMed ID: 17203305
Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.
Jeyakumar M, Liu XF, Erdjument-Bromage H, Tempst P, Bagchi MK
J Biol Chem. 2007
PubMed ID: 17242407
Decreased PARP-1 levels accelerate embryonic lethality but attenuate neuronal apoptosis in DNA polymerase beta-deficient mice.
Sugo N, Niimi N, Aratani Y, Masutani M, Suzuki H, Koyama H
Biochem Biophys Res Commun. 2007
PubMed ID: 17257586
Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase.
Gao H, Coyle DL, Meyer-Ficca ML, Meyer RG, Jacobson EL, Wang ZQ, Jacobson MK
Exp Cell Res. 2007
PubMed ID: 17276427
Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1.
Berger F, Lau C, Ziegler M
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360427
PARP1 Val762Ala polymorphism reduces enzymatic activity.
Wang XG, Wang ZQ, Tong WM, Shen Y
Biochem Biophys Res Commun. 2007
PubMed ID: 17214964
The adenoviral E4orf6 protein induces atypical apoptosis in response to DNA damage.
Hart LS, Ornelles D, Koumenis C
J Biol Chem. 2007
PubMed ID: 17172468
Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1.
Chen Y, Schnetz MP, Irarrazabal CE, Shen RF, Williams CK, Burg MB, Ferraris JD
Am J Physiol Renal Physiol. 2007
PubMed ID: 17148781
A role for the HOXB7 homeodomain protein in DNA repair.
Rubin E, Wu X, Zhu T, Cheung JC, Chen H, Lorincz A, Pandita RK, Sharma GG, Ha HC, Gasson J, Hanakahi LA, Pandita TK, Sukumar S
Cancer Res. 2007
PubMed ID: 17308091
[Polymorphic markers Val762Ala and Leu54Phe of the ADPRT1 gene associated with chronic glomerulonephritis in Russian patients from the city of Moscow]
Shestakov AE, Kamyshova ES, Petrosian EK, Kutyrina IM, Savost'ianov KV, Nosikov VV
Genetika. 2007
PubMed ID: 17385326
Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.
Berndt SI, Huang WY, Fallin MD, Helzlsouer KJ, Platz EA, Weissfeld JL, Church TR, Welch R, Chanock SJ, Hayes RB
Cancer Res. 2007
PubMed ID: 17283177
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura Y, Imai K, Hirohashi S, Yamada T
Cancer Res. 2007
PubMed ID: 17283121
Expression of adhesion molecular proteins in the cochlear lateral wall of normal and PARP-1 mutant mice.
Shi X, Nuttall AL
Hear Res. 2007
PubMed ID: 17184942
DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation.
Cohen-Armon M, Visochek L, Rozensal D, Kalal A, Geistrikh I, Klein R, Bendetz-Nezer S, Yao Z, Seger R
Mol Cell. 2007
PubMed ID: 17244536
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells.
Mortusewicz O, Amé JC, Schreiber V, Leonhardt H
Nucleic Acids Res. 2007
PubMed ID: 17982172
Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1.
Zaniolo K, Desnoyers S, Leclerc S, Guérin SL
BMC Mol Biol. 2007
PubMed ID: 17961220
Genetic sequence variations and ADPRT haplotype analysis in French Canadian families with high risk of breast cancer.
Durocher F, Labrie Y, Ouellette G, INHERIT BRCAs, Simard J
J Hum Genet. 2007
PubMed ID: 17943227
[Specific features of spontaneous carcinogenesis and survival in female mice 129/Sv PARP-1+]
Piskunova TS, Iurova MN, Semenchenko AV, Zabezhinskiĭ MA, Popovich IG, Anisimov VN
Vopr Onkol. 2007
PubMed ID: 17649737
Poly(ADP-ribose) polymerase offers protection against oxidative and alkylation damage to the nuclear and mitochondrial genomes of the retinal pigment epithelium.
Jarrett SG, Boulton ME
Ophthalmic Res. 2007
PubMed ID: 17596754
Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with type 2 diabetes and microangiopathy.
Adaikalakoteswari A, Rema M, Mohan V, Balasubramanyam M
Int J Biochem Cell Biol. 2007
PubMed ID: 17540609
Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.
Aguilar-Quesada R, Muñoz-Gámez JA, Martín-Oliva D, Peralta A, Valenzuela MT, Matínez-Romero R, Quiles-Pérez R, Menissier-de Murcia J, de Murcia G, de Almodóvar MR, Oliver FJ
BMC Mol Biol. 2007
PubMed ID: 17459151
Interaction between poly(ADP-ribose) polymerase 1 and interleukin 1A genes is associated with Alzheimer's disease risk.
Infante J, Llorca J, Mateo I, Rodríguez-Rodríguez E, Sánchez-Quintana C, Sánchez-Juan P, Fernández-Viadero C, Peña N, Berciano J, Combarros O
Dement Geriatr Cogn Disord. 2007
PubMed ID: 17290104
High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility.
Huang M, Dinney CP, Lin X, Lin J, Grossman HB, Wu X
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17220334
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Maruyama T, Nara K, Yoshikawa H, Suzuki N
Clin Exp Immunol. 2007
PubMed ID: 17177976
The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.
Ouararhni K, Hadj-Slimane R, Ait-Si-Ali S, Robin P, Mietton F, Harel-Bellan A, Dimitrov S, Hamiche A
Genes Dev. 2006
PubMed ID: 17158748
Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration.
Runyan C, Schaible K, Molyneaux K, Wang Z, Levin L, Wylie C
Development. 2006
PubMed ID: 17107997
Heterozygous CuZn superoxide dismutase deficiency produces a vascular phenotype with aging.
Didion SP, Kinzenbaw DA, Schrader LI, Faraci FM
Hypertension. 2006
PubMed ID: 17043164
Poly(ADP-ribose) (PAR) polymer is a death signal.
Andrabi SA, Kim NS, Yu SW, Wang H, Koh DW, Sasaki M, Klaus JA, Otsuka T, Zhang Z, Koehler RC, Hurn PD, Poirier GG, Dawson VL, Dawson TM
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17116882
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death.
Yu SW, Andrabi SA, Wang H, Kim NS, Poirier GG, Dawson TM, Dawson VL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17116881
Mitotic phosphorylation of tankyrase, a PARP that promotes spindle assembly, by GSK3.
Yeh TY, Sbodio JI, Chi NW
Biochem Biophys Res Commun. 2006
PubMed ID: 17026964
PARP-1 interaction with VP1 capsid protein regulates polyomavirus early gene expression.
Carbone M, Reale A, Di Sauro A, Sthandier O, Garcia MI, Maione R, Caiafa P, Amati P
J Mol Biol. 2006
PubMed ID: 16979186
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
Bentle MS, Reinicke KE, Bey EA, Spitz DR, Boothman DA
J Biol Chem. 2006
PubMed ID: 16920718
Poly(ADP-ribose) polymerase-1 inhibition prevents eosinophil recruitment by modulating Th2 cytokines in a murine model of allergic airway inflammation: a potential specific effect on IL-5.
Oumouna M, Mustapha O, Datta R, Oumouna-Benachour K, Suzuki Y, Hans C, Matthews K, Fallon K, Boulares H
J Immunol. 2006
PubMed ID: 17056581
RANKL treatment releases the negative regulation of the poly(ADP-ribose) polymerase-1 on Tcirg1 gene expression during osteoclastogenesis.
Beranger GE, Momier D, Rochet N, Quincey D, Guigonis JM, Samson M, Carle GF, Scimeca JC
J Bone Miner Res. 2006
PubMed ID: 17002555
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
Poly(ADP-ribosyl)ation regulates heat shock factor-1 activity and the heat shock response in murine fibroblasts.
Fossati S, Formentini L, Wang ZQ, Moroni F, Chiarugi A
Biochem Cell Biol. 2006
PubMed ID: 17167533
A stronger DNA damage-induced G2 checkpoint due to over-activated CHK1 in the absence of PARP-1.
Lu HR, Wang X, Wang Y
Cell Cycle. 2006
PubMed ID: 17102615
Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy.
Pillai JB, Gupta M, Rajamohan SB, Lang R, Raman J, Gupta MP
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16632544
Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.
Geraets L, Moonen HJ, Wouters EF, Bast A, Hageman GJ
Biochem Pharmacol. 2006
PubMed ID: 16870158
The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions.
Li Y, Oh HJ, Lau YF
Mol Cell Endocrinol. 2006
PubMed ID: 16904257
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.
Yélamos J, Monreal Y, Saenz L, Aguado E, Schreiber V, Mota R, Fuente T, Minguela A, Parrilla P, de Murcia G, Almarza E, Aparicio P, Ménissier-de Murcia J
EMBO J. 2006
PubMed ID: 16946705
Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts.
Gunji A, Uemura A, Tsutsumi M, Nozaki T, Kusuoka O, Omura K, Suzuki H, Nakagama H, Sugimura T, Masutani M
Cancer Lett. 2006
PubMed ID: 16338061
Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes.
Tóth-Zsámboki E, Horváth E, Vargova K, Pankotai E, Murthy K, Zsengellér Z, Bárány T, Pék T, Fekete K, Kiss RG, Préda I, Lacza Z, Gerö D, Szabó C
Mol Med. 2006
PubMed ID: 17225870
Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma.
Li C, Liu Z, Wang LE, Strom SS, Lee JE, Gershenwald JE, Ross MI, Mansfield PF, Cormier JN, Prieto VG, Duvic M, Grimm EA, Wei Q
Carcinogenesis. 2006
PubMed ID: 16621887
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.
Li T, Santockyte R, Shen RF, Tekle E, Wang G, Yang DC, Chock PB
Arch Biochem Biophys. 2006
PubMed ID: 16620772
Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer.
Miao X, Zhang X, Zhang L, Guo Y, Hao B, Tan W, He F, Lin D
Gastroenterology. 2006
PubMed ID: 16890595
Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse hearts.
Zhou HZ, Swanson RA, Simonis U, Ma X, Cecchini G, Gray MO
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16582021
Spatial and temporal expression profile of pinin during mouse development.
Leu S, Ouyang P
Gene Expr Patterns. 2006
PubMed ID: 16427813
Activation of the poly(ADP-ribose) polymerase pathway in human heart failure.
Molnár A, Tóth A, Bagi Z, Papp Z, Edes I, Vaszily M, Galajda Z, Papp JG, Varró A, Szüts V, Lacza Z, Gerö D, Szabó C
Mol Med. 2006
PubMed ID: 17088946
[Relationship of genetic polymorphism in APE1 and ADPRT to risks of chronic benzene poisoning]
Sun P, Zhang ZB, Wan JX, Jin XP, Xia ZL
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006
PubMed ID: 16889694
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.
Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG
Science. 2006
PubMed ID: 16794079
BubR1 is involved in regulation of DNA damage responses.
Fang Y, Liu T, Wang X, Yang YM, Deng H, Kunicki J, Traganos F, Darzynkiewicz Z, Lu L, Dai W
Oncogene. 2006
PubMed ID: 16449973
Contractile dysfunction in experimental cardiac allograft rejection: role of the poly (ADP-ribose) polymerase pathway.
Szabó G, Bährle S, Stumpf N, Szabó C, Hagl S
Transpl Int. 2006
PubMed ID: 16771873
The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest.
Du YC, Gu S, Zhou J, Wang T, Cai H, Macinnes MA, Bradbury EM, Chen X
Mol Cell Proteomics. 2006
PubMed ID: 16522924
Poly(ADP-ribose) polymerase (PARP) polymorphisms associated with nephritis and arthritis in systemic lupus erythematosus.
Hur JW, Sung YK, Shin HD, Park BL, Cheong HS, Bae SC
Rheumatology (Oxford). 2006
PubMed ID: 16461442
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice.
Ogawa K, Masutani M, Kato K, Tang M, Kamada N, Suzuki H, Nakagama H, Sugimura T, Shirai T
Cancer Lett. 2006
PubMed ID: 15955622
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Kauppinen TM, Chan WY, Suh SW, Wiggins AK, Huang EJ, Swanson RA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16627622
In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage.
Yin H, Glass J
J Biol Chem. 2006
PubMed ID: 16490787
KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.
Midorikawa R, Takei Y, Hirokawa N
Cell. 2006
PubMed ID: 16630823
Nitric oxide-dependent negative feedback of PARP-1 trans-activation of the inducible nitric-oxide synthase gene.
Yu Z, Kuncewicz T, Dubinsky WP, Kone BC
J Biol Chem. 2006
PubMed ID: 16464859
Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage.
Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P
Cell Cycle. 2006
PubMed ID: 16628003
A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34.
Vats KR, Ishwad C, Singla I, Vats A, Ferrell R, Ellis D, Moritz M, Surti U, Jayakar P, Frederick DR, Vats AN
J Am Soc Nephrol. 2006
PubMed ID: 16565260
Down-regulation of PARP-1, but not of Ku80 or DNA-PKcs', results in higher gene targeting efficiency.
Domínguez-Bendala J, Masutani M, McWhir J
Cell Biol Int. 2006
PubMed ID: 16504547
PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.
Gomez M, Wu J, Schreiber V, Dunlap J, Dantzer F, Wang Y, Liu Y
Mol Biol Cell. 2006
PubMed ID: 16436506
TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.
Zhang W, Hirschler-Laszkiewicz I, Tong Q, Conrad K, Sun SC, Penn L, Barber DL, Stahl R, Carey DJ, Cheung JY, Miller BA
Am J Physiol Cell Physiol. 2006
PubMed ID: 16306129
Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair.
Heale JT, Ball AR, Schmiesing JA, Kim JS, Kong X, Zhou S, Hudson DF, Earnshaw WC, Yokomori K
Mol Cell. 2006
PubMed ID: 16543152
Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway.
Audebert M, Salles B, Weinfeld M, Calsou P
J Mol Biol. 2006
PubMed ID: 16364363
Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Zhang Y, Newcomb PA, Egan KM, Titus-Ernstoff L, Chanock S, Welch R, Brinton LA, Lissowska J, Bardin-Mikolajczak A, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16492928
The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1.
Muthumani K, Choo AY, Zong WX, Madesh M, Hwang DS, Premkumar A, Thieu KP, Emmanuel J, Kumar S, Thompson CB, Weiner DB
Nat Cell Biol. 2006
PubMed ID: 16429131
Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients.
Chen JY, Wang CM, Lu SC, Chou YH, Luo SF
Clin Exp Immunol. 2006
PubMed ID: 16412052
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis.
Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T
EMBO J. 2006
PubMed ID: 16407974
Identification of poly(ADP-ribose)polymerase-1 and Ku70/Ku80 as transcriptional regulators of S100A9 gene expression.
Grote J, König S, Ackermann D, Sopalla C, Benedyk M, Los M, Kerkhoff C
BMC Mol Biol. 2006
PubMed ID: 17187679
Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation.
Huang JY, Chen WH, Chang YL, Wang HT, Chuang WT, Lee SC
Nucleic Acids Res. 2006
PubMed ID: 16682447
[Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC1 to risk of gastric cancer]
Zhang Z, Miao XP, Tan W, Guo YL, Zhang XM, Lin DX
Ai Zheng. 2006
PubMed ID: 16405741
Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
García S, Bodaño A, González A, Forteza J, Gómez-Reino JJ, Conde C
Arthritis Res Ther. 2006
PubMed ID: 16356201
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.
Zhai X, Liu J, Hu Z, Wang S, Qing J, Wang X, Jin G, Gao J, Wang X, Shen H
Oncol Rep. 2006
PubMed ID: 16328064
Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Pillai JB, Isbatan A, Imai S, Gupta MP
J Biol Chem. 2005
PubMed ID: 16207712
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
Hassa PO, Haenni SS, Buerki C, Meier NI, Lane WS, Owen H, Gersbach M, Imhof R, Hottiger MO
J Biol Chem. 2005
PubMed ID: 16204234
The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development.
Desmots F, Russell HR, Lee Y, Boyd K, McKinnon PJ
Mol Cell Biol. 2005
PubMed ID: 16287848
Poly(ADP-ribose)polymerase activity is reduced in circulating mononuclear cells from type 2 diabetic patients.
Tempera I, Cipriani R, Campagna G, Mancini P, Gatti A, Guidobaldi L, Pantellini F, Mandosi E, Sensi M, Quesada P, Mario UD, D'Erme M, Morano S
J Cell Physiol. 2005
PubMed ID: 15895395
DNA-induced dimerization of poly(ADP-ribose) polymerase-1 triggers its activation.
Pion E, Ullmann GM, Amé JC, Gérard D, de Murcia G, Bombarda E
Biochemistry. 2005
PubMed ID: 16262266
Role of poly (ADP-ribose) polymerase in kidney transplant and its relationship with delayed renal function: multivariate analysis.
O'Valle F, Benítez MC, Gómez-Morales M, Bravo J, Osuna A, Martin-Oliva D, Oliver FJ, Del Moral RG
Transplant Proc. 2005
PubMed ID: 16386505
Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest.
Harnacke K, Kruhøffer M, Orntoft TF, Hass R
Eur J Cell Biol. 2005
PubMed ID: 16323285
Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population.
Zhang Z, Wan J, Jin X, Jin T, Shen H, Lu D, Xia Z
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 16284386
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Deschênes F, Massip L, Garand C, Lebel M
Hum Mol Genet. 2005
PubMed ID: 16195394
PARP-1-dependent 3-nitrotyrosine protein modification after DNA damage.
Siles E, Martinez-Lara E, Núñez MI, Muñoz-Gámez JA, Martín-Oliva D, Valenzuela MT, Peinado MA, Ruiz de Almodóvar JM, Javier Oliver F
J Cell Biochem. 2005
PubMed ID: 16052507
Pivotal role of Akt activation in mitochondrial protection and cell survival by poly(ADP-ribose)polymerase-1 inhibition in oxidative stress.
Tapodi A, Debreceni B, Hanto K, Bognar Z, Wittmann I, Gallyas F, Varbiro G, Sumegi B
J Biol Chem. 2005
PubMed ID: 16115861
Co-localization of PARP-1 and lamin B in the nuclear architecture: a halo-fluorescence- and confocal-microscopy study.
Vidaković M, Koester M, Goetze S, Winkelmann S, Klar M, Poznanović G, Bode J
J Cell Biochem. 2005
PubMed ID: 16052477
Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage.
Monaco L, Kolthur-Seetharam U, Loury R, Murcia JM, de Murcia G, Sassone-Corsi P
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16179389
Mitochondrial impairment induced by poly(ADP-ribose) polymerase-1 activation in cortical neurons after oxygen and glucose deprivation.
Tanaka S, Takehashi M, Iida S, Kitajima T, Kamanaka Y, Stedeford T, Banasik M, Ueda K
J Neurochem. 2005
PubMed ID: 16181422
Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death.
Horton JK, Stefanick DF, Wilson SH
DNA Repair (Amst). 2005
PubMed ID: 16002346
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Proteomic evidence for roles for nucleolin and poly[ADP-ribosyl] transferase in drug resistance.
Fu Z, Fenselau C
J Proteome Res. 2005
PubMed ID: 16212410
Poly(ADP-ribose) polymerase-1 is a novel nuclear target for cholinergic receptor signaling in the hippocampus.
Strosznajder RP, Jesko H, Adamczyk A
J Physiol Pharmacol. 2005
PubMed ID: 16204795
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.
Helleday T, Bryant HE, Schultz N
Cell Cycle. 2005
PubMed ID: 16123586
Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.
Thorslund T, von Kobbe C, Harrigan JA, Indig FE, Christiansen M, Stevnsner T, Bohr VA
Mol Cell Biol. 2005
PubMed ID: 16107709
Poly(ADP-ribose)polymerase-1 is required for integration of the human immunodeficiency virus type 1 genome near centromeric alphoid DNA in human and murine cells.
Kameoka M, Nukuzuma S, Itaya A, Tanaka Y, Ota K, Inada Y, Ikuta K, Yoshihara K
Biochem Biophys Res Commun. 2005
PubMed ID: 16002043
PolyADP-ribosylation is involved in neurotrophic activity.
Visochek L, Steingart RA, Vulih-Shultzman I, Klein R, Priel E, Gozes I, Cohen-Armon M
J Neurosci. 2005
PubMed ID: 16093393
Poly (ADP-ribose) polymerase-1 haplotypes are associated with coeliac disease.
Rueda B, Koeleman BP, López-Nevot MA, Ortega E, Maldonado J, López M, Polanco I, Martín J
Int J Immunogenet. 2005
PubMed ID: 16026592
Regulation of the poly(ADP-ribose) polymerase-1 gene expression by the transcription factors Sp1 and Sp3 is under the influence of cell density in primary cultured cells.
Zaniolo K, Rufiange A, Leclerc S, Desnoyers S, Guérin SL
Biochem J. 2005
PubMed ID: 15777284
Clinical perspectives of PARP inhibitors.
Graziani G, Szabó C
Pharmacol Res. 2005
PubMed ID: 15911339
Involvement of poly(ADP-ribose) polymerase 1 in ERBB2 expression in rheumatoid synovial cells.
Kitamura T, Sekimata M, Kikuchi S, Homma Y
Am J Physiol Cell Physiol. 2005
PubMed ID: 15743888
Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation.
Zhang Y, Zhang X, Park TS, Gidday JM
J Cereb Blood Flow Metab. 2005
PubMed ID: 15729291
p53 deficiency does not affect mutation rate in the mouse germline.
Burr KL, Smith AG, Dubrova YE
Oncogene. 2005
PubMed ID: 15806156
Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.
Idogawa M, Yamada T, Honda K, Sato S, Imai K, Hirohashi S
Gastroenterology. 2005
PubMed ID: 15940627
Proteomic analysis of complexes formed by human topoisomerase I.
Czubaty A, Girstun A, Kowalska-Loth B, Trzcińska AM, Purta E, Winczura A, Grajkowski W, Staroń K
Biochim Biophys Acta. 2005
PubMed ID: 15848144
Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpins.
Potaman VN, Shlyakhtenko LS, Oussatcheva EA, Lyubchenko YL, Soldatenkov VA
J Mol Biol. 2005
PubMed ID: 15826658
Misregulation of poly(ADP-ribose) polymerase-1 activity and cell type-specific loss of poly(ADP-ribose) synthesis in the cerebellum of aged rats.
Malanga M, Romano M, Ferone A, Petrella A, Monti G, Jones R, Limatola E, Farina B
J Neurochem. 2005
PubMed ID: 15857403
Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction.
Cipriani G, Rapizzi E, Vannacci A, Rizzuto R, Moroni F, Chiarugi A
J Biol Chem. 2005
PubMed ID: 15750180
Regulation of poly(ADP-ribose) polymerase-1 by DNA structure-specific binding.
Lonskaya I, Potaman VN, Shlyakhtenko LS, Oussatcheva EA, Lyubchenko YL, Soldatenkov VA
J Biol Chem. 2005
PubMed ID: 15737996
Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest after DNA methylating agent exposure.
Horton JK, Stefanick DF, Naron JM, Kedar PS, Wilson SH
J Biol Chem. 2005
PubMed ID: 15701627
Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1.
West JD, Ji C, Marnett LJ
J Biol Chem. 2005
PubMed ID: 15703174
Establishment of an immortalized PARP-1-/- murine endothelial cell line: a new tool to study PARP-1 mediated endothelial cell dysfunction.
Carrillo A, Monreal Y, Ramirez P, Suarez E, Parrilla P, Menissier-de Murcia J, de Murcia G, Alvarez-Vallina L, Yélamos J
J Cell Biochem. 2005
PubMed ID: 15696577
Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation.
Erdélyi K, Bakondi E, Gergely P, Szabó C, Virág L
Cell Mol Life Sci. 2005
PubMed ID: 15868400
Role of poly-(ADP-ribose) polymerase in transplant acute tubular necrosis and its relationship with delayed renal function.
O'Valle F, Benítez MC, Gómez-Morales M, Bravo J, Osuna A, Del Moral RM, Martín-Oliva D, Oliver FJ, Del Moral RG
Transplant Proc. 2005
PubMed ID: 15866623
Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.
Parsons JL, Dianova II, Allinson SL, Dianov GL
FEBS J. 2005
PubMed ID: 15819892
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator.
Pavri R, Lewis B, Kim TK, Dilworth FJ, Erdjument-Bromage H, Tempst P, de Murcia G, Evans R, Chambon P, Reinberg D
Mol Cell. 2005
PubMed ID: 15808511
Role of lipopolysaccharide and cecal ligation and puncture on blood coagulation and inflammation in sensitive and resistant mice models.
Corral J, Yélamos J, Hernández-Espinosa D, Monreal Y, Mota R, Arcas I, Miñano A, Parrilla P, Vicente V
Am J Pathol. 2005
PubMed ID: 15793289
Involvement of HIV-1 protease in virus-induced cell killing.
Ventoso I, Navarro J, Muñoz MA, Carrasco L
Antiviral Res. 2005
PubMed ID: 15781132
Association study of detoxification genes in age related macular degeneration.
Esfandiary H, Chakravarthy U, Patterson C, Young I, Hughes AE
Br J Ophthalmol. 2005
PubMed ID: 15774926
Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases.
Acheampong EA, Parveen Z, Muthoga LW, Kalayeh M, Mukhtar M, Pomerantz RJ
J Virol. 2005
PubMed ID: 15767427
Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection.
McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD
J Cereb Blood Flow Metab. 2005
PubMed ID: 15689952
ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis.
Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V
Cell Death Differ. 2005
PubMed ID: 15650754
Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.
Mayeur GL, Kung WJ, Martinez A, Izumiya C, Chen DJ, Kung HJ
J Biol Chem. 2005
PubMed ID: 15640154
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
Yu M, Schreek S, Cerni C, Schamberger C, Lesniewicz K, Poreba E, Vervoorts J, Walsemann G, Grötzinger J, Kremmer E, Mehraein Y, Mertsching J, Kraft R, Austen M, Lüscher-Firzlaff J, Lüscher B
Oncogene. 2005
PubMed ID: 15674325
Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria.
Adamczyk A, Czapski GA, Jeśko H, Strosznajder RP
J Physiol Pharmacol. 2005
PubMed ID: 16077187
Nuclear-targeting autoantibodies induced nuclear PARP cleavage accompanied by more pronounced decrease of peripheral white blood cells than Ro/SSA and La/SSB antigen-targeting autoantibodies.
Böhm I
J Clin Immunol. 2005
PubMed ID: 15821886
Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.
Chiba-Falek O, Kowalak JA, Smulson ME, Nussbaum RL
Am J Hum Genet. 2005
PubMed ID: 15672325
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
Cover C, Fickert P, Knight TR, Fuchsbichler A, Farhood A, Trauner M, Jaeschke H
Toxicol Sci. 2005
PubMed ID: 15601672
The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.
Newton CJ, Bilko D, Tichomirowa M, Renner U, Stalla GK
Endocrinology. 2005
PubMed ID: 15564335
Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent.
Shibata A, Kamada N, Masumura K, Nohmi T, Kobayashi S, Teraoka H, Nakagama H, Sugimura T, Suzuki H, Masutani M
Oncogene. 2005
PubMed ID: 15608683
Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death.
Kauppinen TM, Swanson RA
J Immunol. 2005
PubMed ID: 15699164
Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer.
Zhang X, Miao X, Liang G, Hao B, Wang Y, Tan W, Li Y, Guo Y, He F, Wei Q, Lin D
Cancer Res. 2005
PubMed ID: 15705867
Mechanism of early biphasic activation of poly(ADP-ribose) polymerase-1 in response to ultraviolet B radiation.
Vodenicharov MD, Ghodgaonkar MM, Halappanavar SS, Shah RG, Shah GM
J Cell Sci. 2005
PubMed ID: 15657079
Progesterone receptor modulator CDB-2914 down-regulates proliferative cell nuclear antigen and Bcl-2 protein expression and up-regulates caspase-3 and poly(adenosine 5'-diphosphate-ribose) polymerase expression in cultured human uterine leiomyoma cells.
Xu Q, Takekida S, Ohara N, Chen W, Sitruk-Ware R, Johansson ED, Maruo T
J Clin Endocrinol Metab. 2005
PubMed ID: 15572421
Gonadotropin-releasing hormone antagonist cetrorelix down-regulates proliferating cell nuclear antigen and epidermal growth factor expression and up-regulates apoptosis in association with enhanced poly(adenosine 5'-diphosphate-ribose) polymerase expressi
Chen W, Yoshida S, Ohara N, Matsuo H, Morizane M, Maruo T
J Clin Endocrinol Metab. 2005
PubMed ID: 15536154
Poly(ADP-ribose) polymerase-1 gene ablation protects mice from ischemic renal injury.
Zheng J, Devalaraja-Narashimha K, Singaravelu K, Padanilam BJ
Am J Physiol Renal Physiol. 2005
PubMed ID: 15494543
Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure.
Pillai JB, Russell HM, Raman J, Jeevanandam V, Gupta MP
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15374823
Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.
Lavoie J, Carter R, Drouin R, Lebel M
Cancer Genet Cytogenet. 2005
PubMed ID: 15642393
Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex.
Parent M, Yung TM, Rancourt A, Ho EL, Vispé S, Suzuki-Matsuda F, Uehara A, Wada T, Handa H, Satoh MS
J Biol Chem. 2005
PubMed ID: 15498776
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Effect of aging and oxidative/genotoxic stress on poly(ADP-ribose) polymerase-1 activity in rat brain.
Strosznajder RP, Jesko H, Adamczyk A
Acta Biochim Pol. 2005
PubMed ID: 16302026
Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice.
Wesselkamper SC, Chen LC, Gordon T
Respir Res. 2005
PubMed ID: 16026622
Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity.
Sukhanova MV, Khodyreva SN, Lebedeva NA, Prasad R, Wilson SH, Lavrik OI
Nucleic Acids Res. 2005
PubMed ID: 15731342
PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli.
Meder VS, Boeglin M, de Murcia G, Schreiber V
J Cell Sci. 2005
PubMed ID: 15615785
Enhanced egg-induced immunopathology correlates with high IFN-gamma in murine schistosomiasis: identification of two epistatic genetic intervals.
Rutitzky LI, Hernandez HJ, Yim YS, Ricklan DE, Finger E, Mohan C, Peter I, Wakeland EK, Stadecker MJ
J Immunol. 2005
PubMed ID: 15611268
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.
Tenev T, Zachariou A, Wilson R, Ditzel M, Meier P
Nat Cell Biol. 2005
PubMed ID: 15580265
Co-localization of poly(ADPR)polymerase 1 (PARP-1) poly(ADPR)polymerase 2 (PARP-2) and related proteins in rat testis nuclear matrix defined by chemical cross-linking.
Tramontano F, Di Meglio S, Quesada P
J Cell Biochem. 2005
PubMed ID: 15517597
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
Audebert M, Salles B, Calsou P
J Biol Chem. 2004
PubMed ID: 15498778
The FHA domain of aprataxin interacts with the C-terminal region of XRCC1.
Date H, Igarashi S, Sano Y, Takahashi T, Takahashi T, Takano H, Tsuji S, Nishizawa M, Onodera O
Biochem Biophys Res Commun. 2004
PubMed ID: 15555565
Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway.
Ju BG, Solum D, Song EJ, Lee KJ, Rose DW, Glass CK, Rosenfeld MG
Cell. 2004
PubMed ID: 15607978
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1.
Kim MY, Mauro S, Gévry N, Lis JT, Kraus WL
Cell. 2004
PubMed ID: 15607977
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.
Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL
J Neurosci. 2004
PubMed ID: 15574746
Activator protein-1 signalling pathway and apoptosis are modulated by poly(ADP-ribose) polymerase-1 in experimental colitis.
Zingarelli B, Hake PW, Burroughs TJ, Piraino G, O'connor M, Denenberg A
Immunology. 2004
PubMed ID: 15554929
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.
Espejel S, Klatt P, Ménissier-de Murcia J, Martín-Caballero J, Flores JM, Taccioli G, de Murcia G, Blasco MA
J Cell Biol. 2004
PubMed ID: 15545322
Genetic and pharmacological inhibition of poly(ADP-ribose) polymerase-1 interferes in the chlamydial life cycle.
Yélamos J, Buendía AJ, Ortega N, Monreal Y, Gallego MC, Sánchez J, Ramírez P, Parrilla P, Caro MR, Aparicio P, Salinas J
Biochem Biophys Res Commun. 2004
PubMed ID: 15474504
Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB.
Zheng L, Szabó C, Kern TS
Diabetes. 2004
PubMed ID: 15504977
Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells.
Nakajima H, Nagaso H, Kakui N, Ishikawa M, Hiranuma T, Hoshiko S
J Biol Chem. 2004
PubMed ID: 15302869
Germline mutation rates at tandem repeat loci in DNA-repair deficient mice.
Barber RC, Miccoli L, van Buul PP, Burr KL, van Duyn-Goedhart A, Angulo JF, Dubrova YE
Mutat Res. 2004
PubMed ID: 15450426
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice.
Pétrilli V, Herceg Z, Hassa PO, Patel NS, Di Paola R, Cortes U, Dugo L, Filipe HM, Thiemermann C, Hottiger MO, Cuzzocrea S, Wang ZQ
J Clin Invest. 2004
PubMed ID: 15489954
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Expression of poly(ADP-ribose) polymerase in human hepatocellular carcinoma and analysis of biopsy specimens obtained under sonographic guidance.
Shimizu S, Nomura F, Tomonaga T, Sunaga M, Noda M, Ebara M, Saisho H
Oncol Rep. 2004
PubMed ID: 15375506
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.
Veuger SJ, Curtin NJ, Smith GC, Durkacz BW
Oncogene. 2004
PubMed ID: 15286704
Poly(ADP-ribosyl)ation as a DNA damage-induced post-translational modification regulating poly(ADP-ribose) polymerase-1-topoisomerase I interaction.
Yung TM, Sato S, Satoh MS
J Biol Chem. 2004
PubMed ID: 15247263
The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function.
Lockett KL, Hall MC, Xu J, Zheng SL, Berwick M, Chuang SC, Clark PE, Cramer SD, Lohman K, Hu JJ
Cancer Res. 2004
PubMed ID: 15342424
Poly(ADP-ribose) polymerase 1 binds to Kaposi's sarcoma-associated herpesvirus (KSHV) terminal repeat sequence and modulates KSHV replication in latency.
Ohsaki E, Ueda K, Sakakibara S, Do E, Yada K, Yamanishi K
J Virol. 2004
PubMed ID: 15331727
PARP-1 gene disruption in mice preferentially protects males from perinatal brain injury.
Hagberg H, Wilson MA, Matsushita H, Zhu C, Lange M, Gustavsson M, Poitras MF, Dawson TM, Dawson VL, Northington F, Johnston MV
J Neurochem. 2004
PubMed ID: 15312162
The expression of PARP, NF-kappa B and parvalbumin is increased in Parkinson disease.
Soós J, Engelhardt JI, Siklós L, Havas L, Majtényi K
Neuroreport. 2004
PubMed ID: 15257133
Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase.
Piconi L, Quagliaro L, Da Ros R, Assaloni R, Giugliano D, Esposito K, Szabó C, Ceriello A
J Thromb Haemost. 2004
PubMed ID: 15304054
RNA interference directed against Poly(ADP-Ribose) polymerase 1 efficiently suppresses human immunodeficiency virus type 1 replication in human cells.
Kameoka M, Nukuzuma S, Itaya A, Tanaka Y, Ota K, Ikuta K, Yoshihara K
J Virol. 2004
PubMed ID: 15280503
PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development.
Huber A, Bai P, de Murcia JM, de Murcia G
DNA Repair (Amst). 2004
PubMed ID: 15279798
Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery.
Zhang C, Yang J, Jennings LK
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 15044192
Crosstalk between PARP-1 and NF-kappaB modulates the promotion of skin neoplasia.
Martín-Oliva D, O'Valle F, Muñoz-Gámez JA, Valenzuela MT, Nuñez MI, Aguilar M, Ruiz de Almodóvar JM, Garcia del Moral R, Oliver FJ
Oncogene. 2004
PubMed ID: 15077172
The human Rap1 protein complex and modulation of telomere length.
O'Connor MS, Safari A, Liu D, Qin J, Songyang Z
J Biol Chem. 2004
PubMed ID: 15100233
Developmental consequences of abnormal folate transport during murine heart morphogenesis.
Tang LS, Wlodarczyk BJ, Santillano DR, Miranda RC, Finnell RH
Birth Defects Res A Clin Mol Teratol. 2004
PubMed ID: 15259034
Poly(ADP-ribose) polymerase-1 inhibits ATM kinase activity in DNA damage response.
Watanabe F, Fukazawa H, Masutani M, Suzuki H, Teraoka H, Mizutani S, Uehara Y
Biochem Biophys Res Commun. 2004
PubMed ID: 15178448
Long-term memory requires polyADP-ribosylation.
Cohen-Armon M, Visochek L, Katzoff A, Levitan D, Susswein AJ, Klein R, Valbrun M, Schwartz JH
Science. 2004
PubMed ID: 15205535
Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.
Hao B, Wang H, Zhou K, Li Y, Chen X, Zhou G, Zhu Y, Miao X, Tan W, Wei Q, Lin D, He F
Cancer Res. 2004
PubMed ID: 15205355
Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain.
Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler IE, Ellisman MH, Green DR
Cell. 2004
PubMed ID: 15186778
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.
Cistulli C, Lavrik OI, Prasad R, Hou E, Wilson SH
DNA Repair (Amst). 2004
PubMed ID: 15135726
Alkylating DNA damage stimulates a regulated form of necrotic cell death.
Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB
Genes Dev. 2004
PubMed ID: 15145826
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.
Ye JZ, de Lange T
Nat Genet. 2004
PubMed ID: 15133513
Ontogeny of poly(ADP-ribose) polymerase-1 in lung and developmental implications.
Ertsey R, Chapin CJ, Kitterman JA, Scavo LM
Am J Respir Cell Mol Biol. 2004
PubMed ID: 14754756
Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.
Di Meglio S, Tramontano F, Cimmino G, Jones R, Quesada P
Biochim Biophys Acta. 2004
PubMed ID: 15158362
Aprataxin, a novel protein that protects against genotoxic stress.
Gueven N, Becherel OJ, Kijas AW, Chen P, Howe O, Rudolph JH, Gatti R, Date H, Onodera O, Taucher-Scholz G, Lavin MF
Hum Mol Genet. 2004
PubMed ID: 15044383
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks.
Yang YG, Cortes U, Patnaik S, Jasin M, Wang ZQ
Oncogene. 2004
PubMed ID: 15021907
HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy.
Xu Y, Kulkosky J, Acheampong E, Nunnari G, Sullivan J, Pomerantz RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15103018
Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition.
Alano CC, Ying W, Swanson RA
J Biol Chem. 2004
PubMed ID: 14960594
Reactive astrocytes express PARP in the central nervous system of SOD(G93A) transgenic mice.
Chung YH, Joo KM, Lee YJ, Shin DH, Cha CI
Brain Res. 2004
PubMed ID: 15019581
Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1.
Li B, Navarro S, Kasahara N, Comai L
J Biol Chem. 2004
PubMed ID: 14734561
Correlation of morphological findings with functional reserve in the aging donor: role of the poly (ADP-ribose) polymerase.
O'Valle F, Benitez MC, Gómez-Morales M, Bravo J, Osuna A, del Moral RM, Martin-Oliva D, Oliver FJ, del Moral RG
Transplant Proc. 2004
PubMed ID: 15110646
Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.
Zingarelli B, Hake PW, O'Connor M, Denenberg A, Wong HR, Kong S, Aronow BJ
Am J Physiol Heart Circ Physiol. 2004
PubMed ID: 14670820
Camptothecin-sensitive relaxation of supercoiled DNA by the topoisomerase I-like activity associated with poly(ADP-ribose) polymerase-1.
Yung TM, Parent M, Ho EL, Satoh MS
J Biol Chem. 2004
PubMed ID: 14715657
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14985505
Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy.
Obrosova IG, Li F, Abatan OI, Forsell MA, Komjáti K, Pacher P, Szabó C, Stevens MJ
Diabetes. 2004
PubMed ID: 14988256
Activation of poly(ADP-ribose) polymerase in circulating leukocytes during myocardial infarction.
Murthy KG, Xiao CY, Mabley JG, Chen M, Szabó C
Shock. 2004
PubMed ID: 14770035
Defective control of mitotic and post-mitotic checkpoints in poly(ADP-ribose) polymerase-1(-/-) fibroblasts after mitotic spindle disruption.
Halappanavar SS, Shah GM
Cell Cycle. 2004
PubMed ID: 14726664
UV irradiation inhibits ABC transporters via generation of ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and glycohydrolase.
Dumitriu IE, Voll RE, Kolowos W, Gaipl US, Heyder P, Kalden JR, Herrmann M
Cell Death Differ. 2004
PubMed ID: 14685157
Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing.
Malanga M, Althaus FR
J Biol Chem. 2004
PubMed ID: 14699148
Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor beta1.
Yang Y, Zhao S, Song J
Int J Biochem Cell Biol. 2004
PubMed ID: 14643888
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species.
Yusufzai TM, Tagami H, Nakatani Y, Felsenfeld G
Mol Cell. 2004
PubMed ID: 14759373
Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.
von Kobbe C, Harrigan JA, Schreiber V, Stiegler P, Piotrowski J, Dawut L, Bohr VA
Nucleic Acids Res. 2004
PubMed ID: 15292449
Transcription regulation of TNF-alpha-early response genes by poly(ADP-ribose) polymerase-1 in murine heart endothelial cells.
Carrillo A, Monreal Y, Ramírez P, Marin L, Parrilla P, Oliver FJ, Yélamos J
Nucleic Acids Res. 2004
PubMed ID: 14762203
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species.
Sidorkina O, Espey MG, Miranda KM, Wink DA, Laval J
Free Radic Biol Med. 2003
PubMed ID: 14642390
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.
von Kobbe C, Harrigan JA, May A, Opresko PL, Dawut L, Cheng WH, Bohr VA
Mol Cell Biol. 2003
PubMed ID: 14612404
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.
Ku MC, Stewart S, Hata A
Biochem Biophys Res Commun. 2003
PubMed ID: 14623329
PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase.
Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Samara R, Espinoza LA, Hassa PO, Hottiger MO, Smulson ME
Oncogene. 2003
PubMed ID: 14627987
Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.
Hassa PO, Buerki C, Lombardi C, Imhof R, Hottiger MO
J Biol Chem. 2003
PubMed ID: 12960163
Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase.
Adelfalk C, Kontou M, Hirsch-Kauffmann M, Schweiger M
FEBS Lett. 2003
PubMed ID: 14596914
Poly(ADP-ribose) polymerase 1 and Ste20-like kinase hKFC act as transcriptional repressors for gamma-2 herpesvirus lytic replication.
Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU
Mol Cell Biol. 2003
PubMed ID: 14585985
Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo.
Ishizuka S, Martin K, Booth C, Potten CS, de Murcia G, Bürkle A, Kirkwood TB
Nucleic Acids Res. 2003
PubMed ID: 14576306
Regulation of alternative splicing by SRrp86 and its interacting proteins.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG
Mol Cell Biol. 2003
PubMed ID: 14559993
Expression of histone acetyltransferases was down-regulated in poly(ADP-ribose) polymerase-1-deficient murine cells.
Ota K, Kameoka M, Tanaka Y, Itaya A, Yoshihara K
Biochem Biophys Res Commun. 2003
PubMed ID: 14521911
Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners.
Frouin I, Maga G, Denegri M, Riva F, Savio M, Spadari S, Prosperi E, Scovassi AI
J Biol Chem. 2003
PubMed ID: 12930846
Enhanced polyadenosine diphosphate-ribosylation in gonadotropin-releasing hormone agonist-treated uterine leiomyoma.
Huang SC, Tang MJ, Cheng YM, Hsu KF, Ho CL, Chou CY
J Clin Endocrinol Metab. 2003
PubMed ID: 14557488
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage.
El-Khamisy SF, Masutani M, Suzuki H, Caldecott KW
Nucleic Acids Res. 2003
PubMed ID: 14500814
Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1.
Garnier P, Ying W, Swanson RA
J Neurosci. 2003
PubMed ID: 12954857
Phosphorylation regulates the interaction and complex formation between wt p53 protein and PARP-1.
Wesierska-Gadek J, Wojciechowski J, Schmid G
J Cell Biochem. 2003
PubMed ID: 12898523
Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair.
Leppard JB, Dong Z, Mackey ZB, Tomkinson AE
Mol Cell Biol. 2003
PubMed ID: 12897160
Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.
Noël G, Giocanti N, Fernet M, Mégnin-Chanet F, Favaudon V
BMC Cell Biol. 2003
PubMed ID: 12866953
Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients.
Hageman GJ, Larik I, Pennings HJ, Haenen GR, Wouters EF, Bast A
Free Radic Biol Med. 2003
PubMed ID: 12853070
Poly(ADPR) polymerase-1 and poly(ADPR) glycohydrolase level and distribution in differentiating rat germinal cells.
Di Meglio S, Denegri M, Vallefuoco S, Tramontano F, Scovassi AI, Quesada P
Mol Cell Biochem. 2003
PubMed ID: 12870658
Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane.
Nozaki T, Fujihara H, Watanabe M, Tsutsumi M, Nakamoto K, Kusuoka O, Kamada N, Suzuki H, Nakagama H, Sugimura T, Masutani M
Cancer Sci. 2003
PubMed ID: 12824873
Reduction but not cleavage of poly(ADP-ribose) polymerase during stress-mediated cell death in the rat hippocampus.
Yun SJ, Lee DJ, Kim MO, Jung B, Kim SO, Sohn NW, Lee EH
Neuroreport. 2003
PubMed ID: 12802178
Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation.
Wieler S, Gagné JP, Vaziri H, Poirier GG, Benchimol S
J Biol Chem. 2003
PubMed ID: 12642583
Poly(ADP-ribose) polymerase-1 (PARP-1) is required in murine cell lines for base excision repair of oxidative DNA damage in the absence of DNA polymerase beta.
Le Page F, Schreiber V, Dherin C, De Murcia G, Boiteux S
J Biol Chem. 2003
PubMed ID: 12637553
Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives.
Hemberger M, Nozaki T, Winterhager E, Yamamoto H, Nakagama H, Kamada N, Suzuki H, Ohta T, Ohki M, Masutani M, Cross JC
Dev Biol. 2003
PubMed ID: 12729565
Central and carboxy-terminal regions of human p53 protein are essential for interaction and complex formation with PARP-1.
Wesierska-Gadek J, Wojciechowski J, Schmid G
J Cell Biochem. 2003
PubMed ID: 12704785
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse.
Ménissier de Murcia J, Ricoul M, Tartier L, Niedergang C, Huber A, Dantzer F, Schreiber V, Amé JC, Dierich A, LeMeur M, Sabatier L, Chambon P, de Murcia G
EMBO J. 2003
PubMed ID: 12727891
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.
Lebel M, Lavoie J, Gaudreault I, Bronsard M, Drouin R
Am J Pathol. 2003
PubMed ID: 12707040
PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.
Augustin A, Spenlehauer C, Dumond H, Ménissier-De Murcia J, Piel M, Schmit AC, Apiou F, Vonesch JL, Kock M, Bornens M, De Murcia G
J Cell Sci. 2003
PubMed ID: 12640039
Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply.
Mocchegiani E, Muzzioli M, Giacconi R, Cipriano C, Gasparini N, Franceschi C, Gaetti R, Cavalieri E, Suzuki H
Mech Ageing Dev. 2003
PubMed ID: 12714254
Poly(ADP-ribose) polymerase-1 activity promotes NF-kappaB-driven transcription and microglial activation: implication for neurodegenerative disorders.
Chiarugi A, Moskowitz MA
J Neurochem. 2003
PubMed ID: 12675907
Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function.
Kanai M, Tong WM, Sugihara E, Wang ZQ, Fukasawa K, Miwa M
Mol Cell Biol. 2003
PubMed ID: 12640128
The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.
Ratts R, Zeng H, Berg EA, Blue C, McComb ME, Costello CE, vanderSpek JC, Murphy JR
J Cell Biol. 2003
PubMed ID: 12668662
Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.
Ko L, Chin WW
J Biol Chem. 2003
PubMed ID: 12519782
A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis.
Pascual M, López-Nevot MA, Cáliz R, Ferrer MA, Balsa A, Pascual-Salcedo D, Martín J
Arthritis Rheum. 2003
PubMed ID: 12632415
Poly(ADP-ribose) polymerase activation and changes in Bax protein expression associated with extracellular ATP-mediated apoptosis in human embryonic kidney 293-P2X7 cells.
Wen LT, Caldwell CC, Knowles AF
Mol Pharmacol. 2003
PubMed ID: 12606781
Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.
Boulares AH, Zoltoski AJ, Sherif ZA, Jolly P, Massaro D, Smulson ME
Am J Respir Cell Mol Biol. 2003
PubMed ID: 12594058
Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells.
Schlegel BP, Starita LM, Parvin JD
Oncogene. 2003
PubMed ID: 12592385
Poly(ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts.
Andreone TL, O'Connor M, Denenberg A, Hake PW, Zingarelli B
J Immunol. 2003
PubMed ID: 12574383
Lethality in PARP-1/Ku80 double mutant mice reveals physiological synergy during early embryogenesis.
Henrie MS, Kurimasa A, Burma S, Ménissier-de Murcia J, de Murcia G, Li GC, Chen DJ
DNA Repair (Amst). 2003
PubMed ID: 12531386
Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation.
Scott GS, Virág L, Szabó C, Hooper DC
Glia. 2003
PubMed ID: 12509801
Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.
Hortobágyi T, Görlach C, Benyó Z, Lacza Z, Hortobágyi S, Wahl M, Harkany T
Neuroscience. 2003
PubMed ID: 14580948
The cellular control enzyme polyADP ribosyl transferase is eliminated in cultured Fanconi anemia fibroblasts at confluency.
Ramirez MH, Adelfalk C, Kontou M, Hirsch-Kauffmann M, Schweiger M
Biol Chem. 2003
PubMed ID: 12674511
Poly(ADP-ribose) polymerase in base excision repair: always engaged, but not essential for DNA damage processing.
Allinson SL, Dianova II, Dianov GL
Acta Biochim Pol. 2003
PubMed ID: 12673357
PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients.
Kim SH, Henkel JS, Beers DR, Sengun IS, Simpson EP, Goodman JC, Engelhardt JI, Siklós L, Appel SH
J Neuropathol Exp Neurol. 2003
PubMed ID: 12528821
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice.
Tong WM, Ohgaki H, Huang H, Granier C, Kleihues P, Wang ZQ
Am J Pathol. 2003
PubMed ID: 12507917
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents.
Pacher P, Cziráki A, Mabley JG, Liaudet L, Papp L, Szabó C
Biochem Pharmacol. 2002
PubMed ID: 12445868
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.
Tong WM, Cortes U, Hande MP, Ohgaki H, Cavalli LR, Lansdorp PM, Haddad BR, Wang ZQ
Cancer Res. 2002
PubMed ID: 12460917
Poly(ADP-ribose) polymerase 1 is not strictly required for infection of murine cells by retroviruses.
Siva AC, Bushman F
J Virol. 2002
PubMed ID: 12414932
HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation.
Nie Z, Phenix BN, Lum JJ, Alam A, Lynch DH, Beckett B, Krammer PH, Sekaly RP, Badley AD
Cell Death Differ. 2002
PubMed ID: 12404116
A novel in vivo post-translational modification of p53 by PARP-1 in MPTP-induced parkinsonism.
Mandir AS, Simbulan-Rosenthal CM, Poitras MF, Lumpkin JR, Dawson VL, Smulson ME, Dawson TM
J Neurochem. 2002
PubMed ID: 12358742
Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc.
Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH
Hum Mol Genet. 2002
PubMed ID: 12217960
Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2.
Benchoua A, Couriaud C, Guégan C, Tartier L, Couvert P, Friocourt G, Chelly J, Ménissier-de Murcia J, Onténiente B
J Biol Chem. 2002
PubMed ID: 12065591
Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with the loss of c-FLIP expression.
Kelly MM, Hoel BD, Voelkel-Johnson C
Cancer Biol Ther. 2002
PubMed ID: 12496481
Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury.
Khandoga A, Enders G, Biberthaler P, Krombach F
Am J Physiol Gastrointest Liver Physiol. 2002
PubMed ID: 12181167
Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases.
Ching JC, Jones NL, Ceponis PJ, Karmali MA, Sherman PM
Infect Immun. 2002
PubMed ID: 12117981
Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.
Saxena A, Saffery R, Wong LH, Kalitsis P, Choo KH
J Biol Chem. 2002
PubMed ID: 12011073
Down-regulation of DNA repair synthesis at DNA single-strand interruptions in poly(ADP-ribose) polymerase-1 deficient murine cell extracts.
Sanderson RJ, Lindahl T
DNA Repair (Amst). 2002
PubMed ID: 12509228
Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor.
Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL
Science. 2002
PubMed ID: 12114629
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.
Schreiber V, Amé JC, Dollé P, Schultz I, Rinaldi B, Fraulob V, Ménissier-de Murcia J, de Murcia G
J Biol Chem. 2002
PubMed ID: 11948190
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging.
Pacher P, Mabley JG, Soriano FG, Liaudet L, Szabó C
Int J Mol Med. 2002
PubMed ID: 12011985
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Poly(ADP-ribose) polymerase turnover alterations do not contribute to PARP overexpression in Ewing's sarcoma cells.
Newman RE, Soldatenkov VA, Dritschilo A, Notario V
Oncol Rep. 2002
PubMed ID: 11956622
Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
Soriano FG, Liaudet L, Szabó E, Virág L, Mabley JG, Pacher P, Szabó C
Shock. 2002
PubMed ID: 11954828
[Distribution of poly(ADP-ribose) polymerase pseudogene polymorphism and association with susceptibility to lung cancer in Chinese people]
Tang L, Ren Z, Zhuang Z, Liu X, Su Z, Huang Y
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002
PubMed ID: 11941587
Poly(ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia.
Ha HC, Hester LD, Snyder SH
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11854472
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.
Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Renz A, Herceg Z, Wang ZQ, Schulze-Osthoff K
Mol Biol Cell. 2002
PubMed ID: 11907276
Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation.
Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjáti K, Szabó C
Br J Pharmacol. 2002
PubMed ID: 11906946
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.
Pacher P, Liaudet L, Bai P, Virag L, Mabley JG, Haskó G, Szabó C
J Pharmacol Exp Ther. 2002
PubMed ID: 11861791
PARP-1 modifies the effectiveness of p53-mediated DNA damage response.
Valenzuela MT, Guerrero R, Núñez MI, Ruiz De Almodóvar JM, Sarker M, de Murcia G, Oliver FJ
Oncogene. 2002
PubMed ID: 11850828
Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a.
Song D, Sakamoto S, Taniguchi T
Biochemistry. 2002
PubMed ID: 11790116
Role of poly(ADP-ribose) polymerase in rapid intracellular acidification induced by alkylating DNA damage.
Affar el B, Shah RG, Dallaire AK, Castonguay V, Shah GM
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11756665
Genomic structure, conservation and FISH mapping of the Rattus norvegicus Adprt gene.
Beneke S, Kappler R, Bürkle A, Scherthan H
Cytogenet Genome Res. 2002
PubMed ID: 12826757
Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.
Lebel M
Carcinogenesis. 2002
PubMed ID: 11756244
Inducible protective processes in animal systems. X. Influence of nicotinamide in methyl methanesulfonate-adapted mouse bone marrow cells.
Guruprasad KP, Vasudev V, Anilkumar MN, Chethan SA
Mutagenesis. 2002
PubMed ID: 11752227
PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites.
Santilli G, Cervellera MN, Johnson TK, Lewis RE, Iacobelli S, Sala A
Oncogene. 2001
PubMed ID: 11781832
The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function.
Hassa PO, Covic M, Hasan S, Imhof R, Hottiger MO
J Biol Chem. 2001
PubMed ID: 11590148
Inhibition of poly(ADP-ribose) polymerase activity accelerates T-cell lymphomagenesis in p53 deficient mice.
Beneke R, Möröy T
Oncogene. 2001
PubMed ID: 11781827
Disruption of poly (ADP-ribose) polymerase (PARP) protects against stress-evoked immunocompromise.
Drazen DL, Bilu D, Edwards N, Nelson RJ
Mol Med. 2001
PubMed ID: 11788790
Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM).
Iwasaki T, Chin WW, Ko L
J Biol Chem. 2001
PubMed ID: 11443112
HIV-1 Tat induces microvascular endothelial apoptosis through caspase activation.
Park IW, Ullrich CK, Schoenberger E, Ganju RK, Groopman JE
J Immunol. 2001
PubMed ID: 11509621
Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability.
Samper E, Goytisolo FA, Ménissier-de Murcia J, González-Suárez E, Cigudosa JC, de Murcia G, Blasco MA
J Cell Biol. 2001
PubMed ID: 11448989
Loss of poly(ADP-ribose) polymerase-1 causes increased tumour latency in p53-deficient mice.
Conde C, Mark M, Oliver FJ, Huber A, de Murcia G, Ménissier-de Murcia J
EMBO J. 2001
PubMed ID: 11432840
Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases.
Gobeil S, Boucher CC, Nadeau D, Poirier GG
Cell Death Differ. 2001
PubMed ID: 11536009
DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.
Tong WM, Hande MP, Lansdorp PM, Wang ZQ
Mol Cell Biol. 2001
PubMed ID: 11359911
A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.
Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R
Oncogene. 2001
PubMed ID: 11420664
ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G.
Riese MJ, Wittinghofer A, Barbieri JT
Biochemistry. 2001
PubMed ID: 11258948
Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration.
Ha HC, Juluri K, Zhou Y, Leung S, Hermankova M, Snyder SH
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11248084
Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis.
Schweiger M, Hennig K, Lerner F, Niere M, Hirsch-Kauffmann M, Specht T, Weise C, Oei SL, Ziegler M
FEBS Lett. 2001
PubMed ID: 11248244
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Vemuri MC, Schiller E, Naegele JR
Cell Death Differ. 2001
PubMed ID: 11319607
Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development.
Ménisser-de Murcia J, Mark M, Wendling O, Wynshaw-Boris A, de Murcia G
Mol Cell Biol. 2001
PubMed ID: 11238919
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.
Simbulan-Rosenthal CM, Rosenthal DS, Luo R, Li JH, Zhang J, Smulson ME
Nucleic Acids Res. 2001
PubMed ID: 11160908
Two-color fluorescence detection of Poly (ADP-Ribose) Polymerase-1 (PARP-1) cleavage and DNA strand breaks in etoposide-induced apoptotic cells.
Soldani C, Bottone MG, Pellicciari C, Scovassi AI
Eur J Histochem. 2001
PubMed ID: 11846007
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity.
Tsutsumi M, Masutani M, Nozaki T, Kusuoka O, Tsujiuchi T, Nakagama H, Suzuki H, Konishi Y, Sugimura T
Carcinogenesis. 2001
PubMed ID: 11159733
Apoptosis enhancement by the HIV-1 Nef protein.
Rasola A, Gramaglia D, Boccaccio C, Comoglio PM
J Immunol. 2001
PubMed ID: 11123279
DNA-Dependent protein kinase is not required for efficient lentivirus integration.
Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z
J Virol. 2000
PubMed ID: 11070027
Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation.
Nucci C, Piccirilli S, Rodinò P, Nisticò R, Grandinetti M, Cerulli L, Leist M, Nicotera P, Bagetta G
Biochem Biophys Res Commun. 2000
PubMed ID: 11097843
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
DNA excision repair and DNA damage-induced apoptosis are linked to Poly(ADP-ribosyl)ation but have different requirements for p53.
Beneke R, Geisen C, Zevnik B, Bauch T, Müller WU, Küpper JH, Möröy T
Mol Cell Biol. 2000
PubMed ID: 10958667
Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase.
Liaudet L, Soriano FG, Szabó E, Virág L, Mabley JG, Salzman AL, Szabo C
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10954738
A cellular defense pathway regulating transcription through poly(ADP-ribosyl)ation in response to DNA damage.
Vispe S, Yung TM, Ritchot J, Serizawa H, Satoh MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10944198
Poly(ADP-ribose) polymerase-1 in the nervous system.
Ha HC, Snyder SH
Neurobiol Dis. 2000
PubMed ID: 10964595
Characterization of sPARP-1. An alternative product of PARP-1 gene with poly(ADP-ribose) polymerase activity independent of DNA strand breaks.
Sallmann FR, Vodenicharov MD, Wang ZQ, Poirier GG
J Biol Chem. 2000
PubMed ID: 10809783
Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis.
Manna SK, Aggarwal BB
J Immunol. 2000
PubMed ID: 10799874
Poly(ADP-ribose) polymerase is a B-MYB coactivator.
Cervellera MN, Sala A
J Biol Chem. 2000
PubMed ID: 10744766
The response of Parp knockout mice against DNA damaging agents.
Masutani M, Nozaki T, Nakamoto K, Nakagama H, Suzuki H, Kusuoka O, Tsutsumi M, Sugimura T
Mutat Res. 2000
PubMed ID: 10767627
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission.
Pieper AA, Blackshaw S, Clements EE, Brat DJ, Krug DK, White AJ, Pinto-Garcia P, Favit A, Conover JR, Snyder SH, Verma A
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10677544
Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury.
Yang Z, Zingarelli B, Szabó C
Shock. 2000
PubMed ID: 10638671
Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.
Nozaki T, Masutani M, Watanabe M, Ochiya T, Hasegawa F, Nakagama H, Suzuki H, Sugimura T
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10557323
Chromosomal aberrations in PARP(-/-) mice: genome stabilization in immortalized cells by reintroduction of poly(ADP-ribose) polymerase cDNA.
Simbulan-Rosenthal CM, Haddad BR, Rosenthal DS, Weaver Z, Coleman A, Luo R, Young HM, Wang ZQ, Ried T, Smulson ME
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10557296
Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice.
Kühnle S, Nicotera P, Wendel A, Leist M
Biochem Biophys Res Commun. 1999
PubMed ID: 10491311
Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability.
d'Adda di Fagagna F, Hande MP, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP
Nat Genet. 1999
PubMed ID: 10471503
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Kozak CA, Su Y, Raj NB, Pitha PM
Mamm Genome. 1999
PubMed ID: 10441734
Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice.
Oliver FJ, Ménissier-de Murcia J, Nacci C, Decker P, Andriantsitohaina R, Muller S, de la Rubia G, Stoclet JC, de Murcia G
EMBO J. 1999
PubMed ID: 10449410
Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro.
Ariumi Y, Masutani M, Copeland TD, Mimori T, Sugimura T, Shimotohno K, Ueda K, Hatanaka M, Noda M
Oncogene. 1999
PubMed ID: 10467406
Inhibition of apoptosis of a PARP(-)/(-)cell line transfected with PARP DNA-binding domain mutants.
Aoufouchi S, Yélamos J, Milstein C
J Mol Biol. 1999
PubMed ID: 10438594
HIV-1 Tat protein is poly(ADP-ribosyl)ated in vitro.
Kameoka M, Tanaka Y, Ota K, Itaya A, Yamamoto K, Yoshihara K
Biochem Biophys Res Commun. 1999
PubMed ID: 10405328
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
Galande S, Kohwi-Shigematsu T
J Biol Chem. 1999
PubMed ID: 10400681
NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.
Chen A, Yanai A, Arama E, Kilfin G, Motro B
Gene. 1999
PubMed ID: 10393247
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.
Amé JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Höger T, Ménissier-de Murcia J, de Murcia G
J Biol Chem. 1999
PubMed ID: 10364231
Inhibition of nuclear receptor signalling by poly(ADP-ribose) polymerase.
Miyamoto T, Kakizawa T, Hashizume K
Mol Cell Biol. 1999
PubMed ID: 10082530
Liver poly(ADP-ribose)polymerase is resistant to cleavage by caspases.
Jones RA, Johnson VL, Hinton RH, Poirier GG, Chow SC, Kass GE
Biochem Biophys Res Commun. 1999
PubMed ID: 10079203
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes.
Pieper AA, Brat DJ, Krug DK, Watkins CC, Gupta A, Blackshaw S, Verma A, Wang ZQ, Snyder SH
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10077636
A dual approach in the study of poly (ADP-ribose) polymerase: in vitro random mutagenesis and generation of deficient mice.
Trucco C, Rolli V, Oliver FJ, Flatter E, Masson M, Dantzer F, Niedergang C, Dutrillaux B, Ménissier-de Murcia J, de Murcia G
Mol Cell Biochem. 1999
PubMed ID: 10331638
Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein.
Schmid G, Wang ZQ, Wesierska-Gadek J
Biochem Biophys Res Commun. 1999
PubMed ID: 10049720
Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.
Zingarelli B, Szabó C, Salzman AL
Gastroenterology. 1999
PubMed ID: 9922314
Sequence, expression and genetic mapping of a rainbow trout retinoblastoma cDNA.
Brunelli JP, Thorgaard GH
Gene. 1999
PubMed ID: 9931482
Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice.
Dantzer F, Ménissier-de Murcia J, Barlow C, Wynshaw-Boris A, de Murcia G
Carcinogenesis. 1999
PubMed ID: 9934867
Reduced stability of regularly spliced but not alternatively spliced p53 protein in PARP-deficient mouse fibroblasts.
Wesierska-Gadek J, Wang ZQ, Schmid G
Cancer Res. 1999
PubMed ID: 9892179
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant.
Oliver FJ, de la Rubia G, Rolli V, Ruiz-Ruiz MC, de Murcia G, Murcia JM
J Biol Chem. 1998
PubMed ID: 9837934
Decreased expression of topoisomerase IIbeta in poly(ADP-ribose) polymerase-deficient cells.
Canitrot Y, de Murcia G, Salles B
Nucleic Acids Res. 1998
PubMed ID: 9801310
Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers.
Shieh WM, Amé JC, Wilson MV, Wang ZQ, Koh DW, Jacobson MK, Jacobson EL
J Biol Chem. 1998
PubMed ID: 9804757
Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice.
Risinger FO, Cunningham CL
Alcohol Clin Exp Res. 1998
PubMed ID: 9756038
Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
Zingarelli B, Salzman AL, Szabó C
Circ Res. 1998
PubMed ID: 9670921
A B-cell-specific DNA recombination complex.
Borggrefe T, Wabl M, Akhmedov AT, Jessberger R
J Biol Chem. 1998
PubMed ID: 9642267
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
Jacobs H, Fukita Y, van der Horst GT, de Boer J, Weeda G, Essers J, de Wind N, Engelward BP, Samson L, Verbeek S, de Murcia JM, de Murcia G, te Riele H, Rajewsky K
J Exp Med. 1998
PubMed ID: 9607915
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage.
Masson M, Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G
Mol Cell Biol. 1998
PubMed ID: 9584196
Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions.
Malanga M, Pleschke JM, Kleczkowska HE, Althaus FR
J Biol Chem. 1998
PubMed ID: 9565608
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication.
Dantzer F, Nasheuer HP, Vonesch JL, de Murcia G, Ménissier-de Murcia J
Nucleic Acids Res. 1998
PubMed ID: 9518481
Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase.
Le Rhun Y, Kirkland JB, Shah GM
Biochem Biophys Res Commun. 1998
PubMed ID: 9535773
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.
Andrade F, Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L
Immunity. 1998
PubMed ID: 9586635
Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase.
Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T
FEBS Lett. 1998
PubMed ID: 9537509
Apoptotic cell death upon contact of CD4+ T lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1.
Ohnimus H, Heinkelein M, Jassoy C
J Immunol. 1997
PubMed ID: 9548463
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.
Morrison C, Smith GC, Stingl L, Jackson SP, Wagner EF, Wang ZQ
Nat Genet. 1997
PubMed ID: 9398855
Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase.
Endres M, Wang ZQ, Namura S, Waeber C, Moskowitz MA
J Cereb Blood Flow Metab. 1997
PubMed ID: 9390645
Isolation of cDNA encoding full-length rat (Rattus norvegicus) poly (ADP-ribose) polymerase.
Beneke S, Meyer R, Bürkle A
Biochem Mol Biol Int. 1997
PubMed ID: 9385436
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Random mutagenesis of the poly(ADP-ribose) polymerase catalytic domain reveals amino acids involved in polymer branching.
Rolli V, O'Farrell M, Ménissier-de Murcia J, de Murcia G
Biochemistry. 1997
PubMed ID: 9315851
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia.
Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH, Dawson VL
Nat Med. 1997
PubMed ID: 9334719
PARP is important for genomic stability but dispensable in apoptosis.
Wang ZQ, Stingl L, Morrison C, Jantsch M, Los M, Schulze-Osthoff K, Wagner EF
Genes Dev. 1997
PubMed ID: 9308963
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.
de Murcia JM, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver FJ, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207086
Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome.
Coll JM, Hickey RJ, Cronkey EA, Jiang HY, Schnaper L, Lee MY, Uitto L, Syvaoja JE, Malkas LH
Oncol Res. 1997
PubMed ID: 9563011
Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.
Nakayama H, Liu Y, Stifani S, Cross JC
Dev Genet. 1997
PubMed ID: 9291577
CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme.
Teraoka H, Yumoto Y, Watanabe F, Tsukada K, Suwa A, Enari M, Nagata S
FEBS Lett. 1996
PubMed ID: 8804412
Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms.
Zhao W, Manley JL
Mol Cell Biol. 1996
PubMed ID: 8628305
Genetic mapping of the gene encoding the alpha1 subunit of neuronal calcium channels.
Lyu M, Kozak CA, Chin H
Mamm Genome. 1996
PubMed ID: 8661716
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks.
Lindahl T, Satoh MS, Poirier GG, Klungland A
Trends Biochem Sci. 1995
PubMed ID: 8533153
Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2.
Gu Y, Sarnecki C, Aldape RA, Livingston DJ, Su MS
J Biol Chem. 1995
PubMed ID: 7642516
Mouse kalinin B1 (laminin beta 3 chain): cloning and tissue distribution.
Utani A, Kopp JB, Kozak CA, Matsuki Y, Amizuka N, Sugiyama S, Yamada Y
Lab Invest. 1995
PubMed ID: 7898049
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.
Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF
Genes Dev. 1995
PubMed ID: 7698643
Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a subunit of epithelial cell laminin.
Sugiyama S, Utani A, Yamada S, Kozak CA, Yamada Y
Eur J Biochem. 1995
PubMed ID: 7882992
On the biological role of the nuclear polymerizing NAD+: protein(ADP-ribosyl) transferase (ADPRT): ADPRT from Dictyostelium discoideum and inactivation of the ADPRT gene in the mouse.
Auer B, Flick K, Wang ZQ, Haidacher D, Jäger S, Berghammer H, Kofler B, Schweiger M, Wagner EF
Biochimie. 1995
PubMed ID: 7578427
Poly(ADP-ribose) polymerase: a molecular nick-sensor.
de Murcia G, Ménissier de Murcia J
Trends Biochem Sci. 1994
PubMed ID: 8016868
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular.
Mendoza-Alvarez H, Alvarez-Gonzalez R
J Biol Chem. 1993
PubMed ID: 8226768
Tat-dependent occlusion of the HIV poly(A) site.
Weichs an der Glon C, Ashe M, Eggermont J, Proudfoot NJ
EMBO J. 1993
PubMed ID: 8491200
The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.
Schreiber V, Molinete M, Boeuf H, de Murcia G, Ménissier-de Murcia J
EMBO J. 1992
PubMed ID: 1505517
Structural analysis of the putative regulatory region of the rat gene encoding poly(ADP-ribose) polymerase.
Potvin F, Thibodeau J, Kirkland JB, Dandenault B, Duchaine C, Poirier GG
FEBS Lett. 1992
PubMed ID: 1601134
Fluorescence in situ mapping of the human nuclear NAD+ ADP-ribosyltransferase gene (ADPRT) and two secondary sites to human chromosomal bands 1q42, 13q34, and 14q24.
Baumgartner M, Schneider R, Auer B, Herzog H, Schweiger M, Hirsch-Kauffmann M
Cytogenet Cell Genet. 1992
PubMed ID: 1424803
The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA.
Ikejima M, Noguchi S, Yamashita R, Ogura T, Sugimura T, Gill DM, Miwa M
J Biol Chem. 1990
PubMed ID: 2123876
Human poly(ADP-ribose) polymerase gene. Cloning of the promoter region.
Yokoyama Y, Kawamoto T, Mitsuuchi Y, Kurosaki T, Toda K, Ushiro H, Terashima M, Sumimoto H, Kuribayashi I, Yamamoto Y
Eur J Biochem. 1990
PubMed ID: 2125269
Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.
Simonin F, Ménissier-de Murcia J, Poch O, Muller S, Gradwohl G, Molinete M, Penning C, Keith G, de Murcia G
J Biol Chem. 1990
PubMed ID: 2121735
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.
Gradwohl G, Ménissier de Murcia JM, Molinete M, Simonin F, Koken M, Hoeijmakers JH, de Murcia G
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2109322
Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene.
Ogura T, Nyunoya H, Takahashi-Masutani M, Miwa M, Sugimura T, Esumi H
Biochem Biophys Res Commun. 1990
PubMed ID: 2108670
Gene mapping of the three subunits of the high affinity FcR for IgE to mouse chromosomes 1 and 19.
Hupp K, Siwarski D, Mock BA, Kinet JP
J Immunol. 1989
PubMed ID: 2531187
Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene.
Auer B, Nagl U, Herzog H, Schneider R, Schweiger M
DNA. 1989
PubMed ID: 2513174
Cloning of rodent cDNA coding the poly(ADP-ribose) polymerase catalytic domain and analysis of mRNA levels during the cell cycle.
Thibodeau J, Gradwohl G, Dumas C, Clairoux-Moreau S, Brunet G, Penning C, Poirier GG, Moreau P
Biochem Cell Biol. 1989
PubMed ID: 2508731
Sequence and organization of the mouse poly (ADP-ribose) polymerase gene.
Huppi K, Bhatia K, Siwarski D, Klinman D, Cherney B, Smulson M
Nucleic Acids Res. 1989
PubMed ID: 2498841
Human nuclear NAD+ ADP-ribosyltransferase: localization of the gene on chromosome 1q41-q42 and expression of an active human enzyme in Escherichia coli.
Herzog H, Zabel BU, Schneider R, Auer B, Hirsch-Kauffmann M, Schweiger M
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2498872
cDNA sequence, protein structure, and chromosomal location of the human gene for poly(ADP-ribose) polymerase.
Cherney BW, McBride OW, Chen DF, Alkhatib H, Bhatia K, Hensley P, Smulson ME
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2891139
Primary structure of human poly(ADP-ribose) synthetase as deduced from cDNA sequence.
Kurosaki T, Ushiro H, Mitsuuchi Y, Suzuki S, Matsuda M, Matsuda Y, Katunuma N, Kangawa K, Matsuo H, Hirose T
J Biol Chem. 1987
PubMed ID: 2824474
Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase.
Uchida K, Morita T, Sato T, Ogura T, Yamashita R, Noguchi S, Suzuki H, Nyunoya H, Miwa M, Sugimura T
Biochem Biophys Res Commun. 1987
PubMed ID: 3120710
Isolation of a cDNA clone for human NAD+: protein ADP-ribosyltransferase.
Schneider R, Auer B, Kühne C, Herzog H, Klocker H, Burtscher HJ, Hirsch-Kauffmann M, Wintersberger U, Schweiger M
Eur J Cell Biol. 1987
PubMed ID: 3121332
Molecular cloning of cDNA for human poly(ADP-ribose) polymerase and expression of its gene during HL-60 cell differentiation.
Suzuki H, Uchida K, Shima H, Sato T, Okamoto T, Kimura T, Miwa M
Biochem Biophys Res Commun. 1987
PubMed ID: 3113420
Poly(ADP-ribose) may signal changing metabolic conditions to the chromatin of mammalian cells.
Loetscher P, Alvarez-Gonzalez R, Althaus FR
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3103132
Cloning and expression of cDNA for human poly(ADP-ribose) polymerase.
Alkhatib HM, Chen DF, Cherney B, Bhatia K, Notario V, Giri C, Stein G, Slattery E, Roeder RG, Smulson ME
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3029772
Purification and characterization of poly (ADP-ribose) synthetase from human placenta.
Ushiro H, Yokoyama Y, Shizuta Y
J Biol Chem. 1987
PubMed ID: 2434482
Purification and characterization of human lymphoid poly(adenosine diphosphate ribose) polymerase.
Carter SG, Berger NA
Biochemistry. 1982
PubMed ID: 6293541
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	Human	Mouse	Rat
Entrez Gene	142	11545	25591
EnsEMBL Gene(s)	ENSG00000143799	ENSMUSG00000026496	ENSRNOG00000003084
Unigene	Hs.177766	Mm.277779	Rn.11327
Homologene	PARP1	Parp1	Parp1
OMIM	173870	N/A	N/A
GeneCards	PARP1	N/A	N/A
Beta Cell Genomics	DT.100031860 DT.319999 DT.92459767 DT.95162798 DT.99930369	DT.101206137 DT.101409410 DT.494075	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	142	11545	25591

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Interactor	Interactor	Sources	Classification	Pubmed IDs
PARP1	MED6	HPRD, BioGRID	empirical	15808511 16204234
PARP1	HDAC5	BioGRID	empirical	21081666
PARP1	PARP2	HPRD, BioGRID	empirical	12217960 11948190
PARP1	PARP3	HPRD, BioGRID	empirical	12640039 20064938
PARP1	RAD50	BioGRID	empirical	15607978
PARP1	TRIM28	BioGRID	empirical	18676401
PARP1	TOPORS	BioGRID	empirical	17803295
PARP1	CDK8	BioGRID	empirical	16204234 15808511
PARP1	CDKN1A	HPRD, BioGRID	empirical	12930846 20303835 20302655
PARP1	RBM14	HPRD, BioGRID	empirical	11443112
PARP1	CARM1	BioGRID	empirical	18280497
PARP1	CEBPA	IntAct	empirical	16490787
PARP1	CENPA	HPRD, BioGRID	empirical	12011073
PARP1	CENPB	HPRD, BioGRID	empirical	12011073 20211142
PARP1	CTCF	BioGRID	empirical	20038529 14759373
PARP1	IMMT	BioGRID	empirical	19762472
PARP1	SUPT16H	BioGRID	empirical	16682447
PARP1	KLF8	BioGRID	empirical	21518760
PARP1	CREBBP	BioGRID	empirical	16204234 15607978
PARP1	SREK1	HPRD, BioGRID	empirical	14559993
PARP1	PARP1	HPRD, IntAct, BioGRID	empirical	12519782 14734561 16204234 15737996 20388712 17283121
PARP1	CTSG	HPRD	empirical	11536009
PARP1	E2F1	HPRD, IntAct	empirical	14627987
PARP1	APLF	MINT, BioGRID	empirical	17396150 20098424
PARP1	EP300	BioGRID	empirical	19622798 16204234 18280497
PARP1	ERCC6	HPRD	empirical	16107709
PARP1	ERG	IntAct	empirical	21575865
PARP1	ESR1	IntAct, BioGRID	empirical	21182205 16794079
PARP1	ETS1	IntAct	empirical	21575865
PARP1	ETV1	IntAct	empirical	21575865
PARP1	ZBTB9	BioGRID	empirical	20211142
PARP1	NCOA6	HPRD, BioGRID	empirical	12519782
PARP1	SWAP70	HPRD, BioGRID	empirical	9642267
PARP1	RRP1B	BioGRID	empirical	19710015
PARP1	FOXO1	BioGRID	empirical	19281796
PARP1	ZNF423	HPRD, BioGRID	empirical	14623329
PARP1	POLA2	BioGRID	empirical	9518481
PARP1	TRIM29	BioGRID	empirical	20211142
PARP1	XRCC6	HPRD, IntAct, BioGRID	empirical	17283121 14734561 16794079 10400681
PARP1	HIST1H2BA	BioGRID	empirical	20525793
PARP1	SENP3	BioGRID	empirical	19622798
PARP1	GBAS	IntAct, BioGRID	empirical	20562859
PARP1	GTF2F1	BioGRID	empirical	16204234
PARP1	SENP1	BioGRID	empirical	19622798
PARP1	GZMB	HPRD	empirical	9586635
PARP1	HIST1H1C	BioGRID	empirical	18258596
PARP1	H2AFX	IntAct, BioGRID	empirical	20085707 20000738 16522924 18406329
PARP1	HIST1H1A	BioGRID	empirical	17214964
PARP1	HDAC1	BioGRID	empirical	16204234 20596014
PARP1	HDAC2	BioGRID	empirical	16204234 20596014
PARP1	HDGF	IntAct	empirical	21907836
PARP1	HIF1A	BioGRID	empirical	18314489
PARP1	HMGA1	BioGRID	empirical	16204234
PARP1	HOXB7	BioGRID	empirical	17308091
PARP1	AIRE	IntAct, BioGRID	empirical	20085707
PARP1	PRMT1	BioGRID	empirical	18280497
PARP1	HES1	BioGRID	empirical	15607978
PARP1	HSPA2	BioGRID	empirical	19607827
PARP1	IKBKB	MINT, IntAct	empirical	14743216
PARP1	LIG3	HPRD, BioGRID	empirical	12897160
PARP1	ARNTL	IntAct	empirical	20832105
PARP1	MYB	BioGRID	empirical	18945670
PARP1	MYBL2	HPRD, BioGRID	empirical	10744766
PARP1	NCL	HPRD	empirical	9642267
PARP1	NEDD8	HPRD, BioGRID	empirical	16620772
PARP1	NFATC1	BioGRID	empirical	18078995
PARP1	NFKB1	HPRD, BioGRID	empirical	11590148 16204234
PARP1	NFKB2	MINT, IntAct	empirical	14743216
PARP1	NPM1	HPRD, BioGRID	empirical	9642267 15607978
PARP1	NRF1	BioGRID	empirical	19181665
PARP1	PCNA	HPRD, BioGRID	empirical	12930846 20303835 20302655 21690293
PARP1	PIAS4	BioGRID	empirical	19779455
PARP1	PDPK1	MINT, IntAct	empirical	15102471
PARP1	POLA1	HPRD, BioGRID	empirical	9563011 9518481
PARP1	POLB	BioGRID	empirical	20303835 20302655
PARP1	POLR2A	BioGRID	empirical	15607978
PARP1	TERF2IP	BioGRID	empirical	15100233
PARP1	POU2F1	HPRD	empirical	9537509
PARP1	POU5F1	IntAct, BioGRID	empirical	20362542
PARP1	MED1	BioGRID	empirical	16204234
PARP1	APTX	HPRD, MINT, IntAct, BioGRID	empirical	15044383 15555565
PARP1	PRKAA1	IntAct, BioGRID	empirical	20562859
PARP1	PRKAB1	IntAct	empirical	17353931
PARP1	PRKDC	HPRD, IntAct, BioGRID	empirical	9398855 20085707 21575865 16794079
PARP1	MAPK1	BioGRID	empirical	17244536
PARP1	MAPK13	IntAct, BioGRID	empirical	19135240
PARP1	MEPCE	BioGRID	empirical	17643375
PARP1	SMARCAD1	BioGRID	empirical	21549307
PARP1	PTK2	BioGRID	empirical	18206965
PARP1	USP36	IntAct, BioGRID	empirical	19615732
PARP1	RARA	HPRD, IntAct, BioGRID	empirical	15808511 19377461
PARP1	BCL2	HPRD, BioGRID	empirical	11790116
PARP1	RELA	HPRD, MINT, IntAct, BioGRID	empirical	11590148 14743216 16204234 18280497
PARP1	RPS3A	HPRD, BioGRID	empirical	11790116
PARP1	RXRA	HPRD, BioGRID	empirical	10082530
PARP1	RYK	BioGRID	empirical	21875946
PARP1	SFPQ	BioGRID	empirical	15607978
PARP1	BMI1	BioGRID	empirical	20668194
PARP1	SMARCA1	BioGRID	empirical	18922045
PARP1	SP1	BioGRID	empirical	17961220
PARP1	SPI1	IntAct	empirical	21575865
PARP1	SRC	BioGRID	empirical	15607978
PARP1	TAF1	BioGRID	empirical	15607978
PARP1	TAF13	BioGRID	empirical	17643375
PARP1	TAL1	MINT, BioGRID	empirical	16407974
PARP1	TCEA2	BioGRID	empirical	17643375
PARP1	TCF4	HPRD	empirical	17283121
PARP1	TCF7L2	IntAct	empirical	17283121
PARP1	BUB1B	BioGRID	empirical	16449973
PARP1	THRA	BioGRID	empirical	15808511 17242407
PARP1	THRB	BioGRID	empirical	17242407
PARP1	TLE1	BioGRID	empirical	15607978
PARP1	TOP1	IntAct, BioGRID	empirical	15848144
PARP1	TOP2A	IntAct	empirical	20085707
PARP1	TOP2B	BioGRID	empirical	16794079 15607978
PARP1	TP53	HPRD, MINT, IntAct, BioGRID	empirical	9565608 12898523 14627987 15044383
PARP1	TRAF1	IntAct	empirical	15102471
PARP1	TRAF2	MINT, IntAct	empirical	14743216
PARP1	TRAF6	MINT, IntAct	empirical	14743216
PARP1	UBC	BioGRID	empirical	16196087 20639865 22118674 18781797 21987572 21139048 21890473 21906983
PARP1	USF1	IntAct, BioGRID	empirical	19303849
PARP1	VHL	BioGRID	empirical	21942715
PARP1	WRN	HPRD, MINT, IntAct	empirical	14734561 14596914
PARP1	XRCC1	HPRD, IntAct, BioGRID	empirical	9584196 14500814 15555565 15044383 20303835 20302655 12897160
PARP1	XRCC5	HPRD, IntAct, BioGRID	empirical	14734561 17283121 20085707 21575865 21679440 16794079 10400681
PARP1	CAMK2A	BioGRID	empirical	15607978
PARP1	RNF146	BioGRID	empirical	21825151
PARP1	LZTR1	BioGRID	empirical	20211142
PARP1	HIST2H2AA3	BioGRID	empirical	20525793
PARP1	CASP1	HPRD	empirical	7642516
PARP1	HIST1H3E	BioGRID	empirical	20504901
PARP1	CASP3	IntAct	empirical	17167422 19759058
PARP1	HIST1H4C	BioGRID	empirical	20525793
PARP1	CASP7	IntAct	empirical	19759058
PARP1	SLX4	IntAct	empirical	19596235
PARP1	CBX2	IntAct	empirical	21282530
PARP1	IKBKG	MINT, IntAct	empirical	14743216
PARP1	HDAC3	BioGRID	empirical	16204234
PARP1	AIFM1	IntAct	empirical	21467298
PARP1	BUB3	HPRD, BioGRID	empirical	12011073
PARP1	MED14	BioGRID	empirical	16204234
PARP1	CD86	IntAct	empirical	21988832
PARP1	MED23	BioGRID	empirical	16204234
PARP1	MED17	BioGRID	empirical	16204234
PARP1	MED7	BioGRID	empirical	16204234
PARP1	H2AFY	HPRD	empirical	17158748
PARP1	CHD1L	BioGRID	empirical	19666485 19661379 22146311
PARP1	CLOCK	IntAct	empirical	20832105
PARP1	IKBKE	IntAct	empirical	17353931
PARP1	KIAA0101	BioGRID	empirical	21628590
PARP1	MED24	BioGRID	empirical	16204234
PARP1	NCAPD2	BioGRID	empirical	16543152
PARP1	THRAP3	BioGRID	empirical	16204234