Home CPE
|
(Human) GRCh37 - chr4:166282346..166419482 (137.14 kb) View in Genome Browser
(Mouse) NCBIM37 - chr8:67071339..67171837 (100.50 kb) View in Genome Browser
HaemAtlas Expression Table for CPE:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CPE:The CPE interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CPE | EIF3M | Sanger Interaction Map | predicted | 15345047 |
| CPE | UTP14A | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | CHD3 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | POLA2 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | GAST | HPRD | empirical | 9369230 |
| CPE | POLDIP2 | HPRD, MINT, IntAct | empirical | 16169070 |
| CPE | GCG | HPRD | empirical | 11375130 |
| CPE | GTF3C1 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | APP | IntAct | empirical | 17934213 |
| CPE | INS | HPRD | empirical | 10966857 7477119 |
| CPE | NTS | HPRD | empirical | 8770919 |
| CPE | MED31 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | PMCH | HPRD | empirical | 8770919 |
| CPE | RIF1 | IntAct | empirical | 16169070 |
| CPE | PRKAA1 | IntAct | empirical | 20368287 |
| CPE | LRIF1 | HPRD, MINT | empirical | 16169070 |
| CPE | ROBO2 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | RPA1 | HPRD, MINT, IntAct, BioGRID | empirical | 16169070 |
| CPE | BDNF | HPRD | empirical | 15664176 |
| CPE | TRH | HPRD | empirical | 12270926 |
| CPE | UBC | BioGRID | empirical | 21906983 |
| CPE | CCK | HPRD | empirical | 9275097 12479974 |
|
|
||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||
|
|
|
Type 1 Diabetes Publications: 19
-
Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.
Chu KY, Briggs MJ, Albrecht T, Drain PF, Johnson JD
Islets. 2011
PubMed ID: 21628999
-
Carboxypeptidase-H autoantibodies differentiate a more latent subset of autoimmune diabetes from phenotypic type 2 diabetes among Chinese adults.
Yang L, Zhou ZG, Tan SZ, Huang G, Jin P, Yan X, Li X, Peng H, Hagopian W
Ann N Y Acad Sci. 2008
PubMed ID: 19120309
-
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.
Jeffrey KD, Alejandro EU, Luciani DS, Kalynyak TB, Hu X, Li H, Lin Y, Townsend RR, Polonsky KS, Johnson JD
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18550819
-
Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells.
Marzban L, Soukhatcheva G, Verchere CB
Endocrinology. 2005
PubMed ID: 15618358
-
Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.
Cawley NX, Rodriguez YM, Maldonado A, Loh YP
Endocrinology. 2003
PubMed ID: 12488357
-
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
Goodge KA, Hutton JC
Semin Cell Dev Biol. 2000
PubMed ID: 10966857
-
Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway.
Qian Y, Varlamov O, Fricker LD
J Biol Chem. 1999
PubMed ID: 10206965
-
Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus.
Leiter EH, Kintner J, Flurkey K, Beamer WG, Naggert JK
Endocrine. 1999
PubMed ID: 10403572
-
Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity.
Utsunomiya N, Ohagi S, Sanke T, Tatsuta H, Hanabusa T, Nanjo K
Diabetologia. 1998
PubMed ID: 9662053
-
Beta-cell lines derived from transgenic Cpe(fat)/Cpe(fat) mice are defective in carboxypeptidase E and proinsulin processing.
Varlamov O, Fricker LD, Furukawa H, Steiner DF, Langley SH, Leiter EH
Endocrinology. 1997
PubMed ID: 9348219
-
Proinsulin targeting to the regulated pathway is not impaired in carboxypeptidase E-deficient Cpefat/Cpefat mice.
Irminger JC, Verchere CB, Meyer K, Halban PA
J Biol Chem. 1997
PubMed ID: 9346885
-
Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing.
Fricker LD, Berman YL, Leiter EH, Devi LA
J Biol Chem. 1996
PubMed ID: 8940036
-
Cloning of candidate autoantigen carboxypeptidase H from a human islet library: sequence identity with human brain CPH.
Alcalde L, Tonacchera M, Costagliola S, Jaraquemada D, Pujol-Borrell R, Ludgate M
J Autoimmun. 1996
PubMed ID: 8864828
-
Induced and spontaneous mutations at Ser202 of carboxypeptidase E. Effect on enzyme expression, activity, and intracellular routing.
Varlamov O, Leiter EH, Fricker L
J Biol Chem. 1996
PubMed ID: 8662840
-
The post-translational processing and intracellular sorting of carboxypeptidase H in the islets of Langerhans.
Guest PC, Arden SD, Rutherford NG, Hutton JC
Mol Cell Endocrinol. 1995
PubMed ID: 8674818
-
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity.
Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, Steiner DF, Carroll RJ, Paigen BJ, Leiter EH
Nat Genet. 1995
PubMed ID: 7663508
-
Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes.
Castaño L, Russo E, Zhou L, Lipes MA, Eisenbarth GS
J Clin Endocrinol Metab. 1991
PubMed ID: 1955501
-
Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse.
Coleman DL, Eicher EM
J Hered. 1990
PubMed ID: 2250094
-
The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing.
Davidson HW, Hutton JC
Biochem J. 1987
PubMed ID: 2822027
Publications: 136
-
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.
Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP
J Clin Invest. 2011
PubMed ID: 21285511
-
Acute inhibition of carboxypeptidase E expression in AtT-20 cells does not affect regulated secretion of ACTH.
Kemppainen RJ, Behrend EN
Regul Pept. 2010
PubMed ID: 20655338
-
Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.
Murthy SR, Pacak K, Loh YP
Cell Mol Neurobiol. 2010
PubMed ID: 21061162
-
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
-
Carboxypeptidase E cytoplasmic tail mediates localization of synaptic vesicles to the pre-active zone in hypothalamic pre-synaptic terminals.
Lou H, Park JJ, Cawley NX, Sarcon A, Sun L, Adams T, Loh YP
J Neurochem. 2010
PubMed ID: 20492353
-
Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density.
Cawley NX, Yanik T, Woronowicz A, Chang W, Marini JC, Loh YP
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20460579
-
Association study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
Am J Med Genet B Neuropsychiatr Genet. 2010
PubMed ID: 20468064
-
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
-
Onset of obesity in carboxypeptidase E-deficient mice and effect on airway responsiveness and pulmonary responses to ozone.
Johnston RA, Zhu M, Hernandez CB, Williams ES, Shore SA
J Appl Physiol. 2010
PubMed ID: 20299617
-
Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11.
Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T
Alcohol Clin Exp Res. 2010
PubMed ID: 20201924
-
Carboxypeptidase E knockout mice exhibit abnormal dendritic arborization and spine morphology in central nervous system neurons.
Woronowicz A, Cawley NX, Chang SY, Koshimizu H, Phillips AW, Xiong ZG, Loh YP
J Neurosci Res. 2010
PubMed ID: 19598241
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
-
Pulmonary responses to subacute ozone exposure in obese vs. lean mice.
Shore SA, Lang JE, Kasahara DI, Lu FL, Verbout NG, Si H, Williams ES, Terry RD, Lee A, Johnston RA
J Appl Physiol. 2009
PubMed ID: 19745193
-
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.
Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D
Nat Med. 2009
PubMed ID: 19767734
-
Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study.
Arnett DK, Devereux RB, Rao DC, Li N, Tang W, Kraemer R, Claas SA, Leon JM, Broeckel U
J Hypertens. 2009
PubMed ID: 19593212
-
Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.
Chen HH, Lee WJ, Fann CS, Bouchard C, Pan WH
Am J Clin Nutr. 2009
PubMed ID: 19491387
-
NOS1AP regulates dendrite patterning of hippocampal neurons through a carboxypeptidase E-mediated pathway.
Carrel D, Du Y, Komlos D, Hadzimichalis NM, Kwon M, Wang B, Brzustowicz LM, Firestein BL
J Neurosci. 2009
PubMed ID: 19553464
-
PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues.
Tang SS, Zhang JH, Liu HX, Li HZ
Mol Cell Endocrinol. 2009
PubMed ID: 19428990
-
Contactin-associated protein (Caspr) 2 interacts with carboxypeptidase E in the CNS.
Oiso S, Takeda Y, Futagawa T, Miura T, Kuchiiwa S, Nishida K, Ikeda R, Kariyazono H, Watanabe K, Yamada K
J Neurochem. 2009
PubMed ID: 19166515
-
Regulation of dopamine transporter activity by carboxypeptidase E.
Zhang H, Li S, Wang M, Vukusic B, Pristupa ZB, Liu F
Mol Brain. 2009
PubMed ID: 19419578
-
Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
Chung WK, Patki A, Matsuoka N, Boyer BB, Liu N, Musani SK, Goropashnaya AV, Tan PL, Katsanis N, Johnson SB, Gregersen PK, Allison DB, Leibel RL, Tiwari HK
Hum Hered. 2009
PubMed ID: 19077438
-
Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing.
Zhang X, Che FY, Berezniuk I, Sonmez K, Toll L, Fricker LD
J Neurochem. 2008
PubMed ID: 19014391
-
A bi-directional carboxypeptidase E-driven transport mechanism controls BDNF vesicle homeostasis in hippocampal neurons.
Park JJ, Cawley NX, Loh YP
Mol Cell Neurosci. 2008
PubMed ID: 18573344
-
Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation.
Wang F, Tong Q
Am J Physiol Cell Physiol. 2008
PubMed ID: 18463231
-
Association of human carboxypeptidase E exon5 gene polymorphisms with angiographical characteristics of coronary atherosclerosis in a Chinese population.
Wang J, Zhang Y, Yang ZJ, Zhu TB, Wang LS, Chen B, Cao KJ, Huang J, Ma WZ, Jia EZ
Acta Pharmacol Sin. 2008
PubMed ID: 18501121
-
Regulation of Fto/Ftm gene expression in mice and humans.
Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18256137
-
Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.
Bae S, Ha TS, Yoon Y, Lee J, Cha HJ, Yoo H, Choe TB, Li S, Sohn I, Kim JY, Kim CS, Jin HO, Lee HC, Park IC, Kim CS, Jin YW, Ahn SK
Int J Mol Med. 2008
PubMed ID: 18288386
-
Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits.
Woronowicz A, Koshimizu H, Chang SY, Cawley NX, Hill JM, Rodriguiz RM, Abebe D, Dorfman C, Senatorov V, Zhou A, Xiong ZG, Wetsel WC, Loh YP
Hippocampus. 2008
PubMed ID: 18570185
-
Molecular scanning of the human carboxypeptidase E gene for mutations in Chinese subjects with coronary atherosclerosis.
Jia EZ, Wang J, Yang ZJ, Zhu TB, Wang LS, Chen B, Cao KJ, Huang J, Ma WZ
Mol Cell Biochem. 2008
PubMed ID: 17957445
-
Association of the mutation for the human carboxypeptidase E gene exon 4 with the severity of coronary artery atherosclerosis.
Jia EZ, Wang J, Yang ZJ, Zhu TB, Wang LS, Wang H, Li CJ, Chen B, Cao KJ, Huang J, Ma WZ
Mol Biol Rep. 2007
PubMed ID: 18080843
-
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain.
Billova S, Galanopoulou AS, Seidah NG, Qiu X, Kumar U
Neuroscience. 2007
PubMed ID: 17543468
-
Carboxypeptidase E in the mouse placenta.
Singh U, Yu Y, Kalinina E, Konno T, Sun T, Ohta H, Wakayama T, Soares MJ, Hemberger M, Fundele RH
Differentiation. 2006
PubMed ID: 17177860
-
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
-
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
-
Altered neuropeptide processing in prefrontal cortex of Cpe (fat/fat) mice: implications for neuropeptide discovery.
Lim J, Berezniuk I, Che FY, Parikh R, Biswas R, Pan H, Fricker LD
J Neurochem. 2006
PubMed ID: 16417576
-
Augmented responses to ozone in obese carboxypeptidase E-deficient mice.
Johnston RA, Theman TA, Shore SA
Am J Physiol Regul Integr Comp Physiol. 2006
PubMed ID: 16002559
-
Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
Singh U, Sun T, Shi W, Schulz R, Nuber UA, Varanou A, Hemberger MC, Elliott RW, Ohta H, Wakayama T, Fundele R
Dev Dyn. 2005
PubMed ID: 16247769
-
Carboxypeptidase E is required for normal synaptic transmission from photoreceptors to the inner retina.
Zhu X, Wu K, Rife L, Cawley NX, Brown B, Adams T, Teofilo K, Lillo C, Williams DS, Loh YP, Craft CM
J Neurochem. 2005
PubMed ID: 16219026
-
Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
St Germain C, Croissandeau G, Mayne J, Baltz JM, Chrétien M, Mbikay M
Mol Reprod Dev. 2005
PubMed ID: 16163737
-
Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules.
Hosaka M, Watanabe T, Sakai Y, Kato T, Takeuchi T
J Cell Sci. 2005
PubMed ID: 16219686
-
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
Hum Mol Genet. 2005
PubMed ID: 15917267
-
Genetic modifiers interact with Cpe(fat) to affect body weight, adiposity, and hyperglycemia.
Collin GB, Maddatu TP, Sen S, Naggert JK
Physiol Genomics. 2005
PubMed ID: 15870393
-
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
-
Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels.
Che FY, Yuan Q, Kalinina E, Fricker LD
J Biol Chem. 2005
PubMed ID: 15572367
-
Sorting and activity-dependent secretion of BDNF require interaction of a specific motif with the sorting receptor carboxypeptidase e.
Lou H, Kim SK, Zaitsev E, Snell CR, Lu B, Loh YP
Neuron. 2005
PubMed ID: 15664176
-
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
-
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits.
Cawley NX, Zhou J, Hill JM, Abebe D, Romboz S, Yanik T, Rodriguiz RM, Wetsel WC, Loh YP
Endocrinology. 2004
PubMed ID: 15358678
-
Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.
He P, Varticovski L, Bowman ED, Fukuoka J, Welsh JA, Miura K, Jen J, Gabrielson E, Brambilla E, Travis WD, Harris CC
Hum Pathol. 2004
PubMed ID: 15492986
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
-
Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice.
Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B
J Lipid Res. 2004
PubMed ID: 15210844
-
Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.
Chiu CH, Lin WD, Huang SY, Lee YH
Genes Dev. 2004
PubMed ID: 15289464
-
Altered biosynthesis of neuropeptide processing enzyme carboxypeptidase E after brain ischemia: molecular mechanism and implication.
Zhou A, Minami M, Zhu X, Bae S, Minthorne J, Lan J, Xiong ZG, Simon RP
J Cereb Blood Flow Metab. 2004
PubMed ID: 15181368
-
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
-
Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice.
Srinivasan S, Bunch DO, Feng Y, Rodriguiz RM, Li M, Ravenell RL, Luo GX, Arimura A, Fricker LD, Eddy EM, Wetsel WC
Endocrinology. 2004
PubMed ID: 14715715
-
Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice.
Lyons MA, Wittenburg H, Li R, Walsh KA, Korstanje R, Churchill GA, Carey MC, Paigen B
Physiol Genomics. 2004
PubMed ID: 14701919
-
Obesity and diabetes in transgenic mice expressing proSAAS.
Wei S, Feng Y, Che FY, Pan H, Mzhavia N, Devi LA, McKinzie AA, Levin N, Richards WG, Fricker LD
J Endocrinol. 2004
PubMed ID: 15012590
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
-
Carboxypeptidase E in rat antropyloric mucosa: distribution in progenitor and mature endocrine cell types.
Hougaard DM, Larsson LI
Histochem Cell Biol. 2004
PubMed ID: 14661109
-
Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI
Dev Biol. 2003
PubMed ID: 14651920
-
Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice.
Suto J, Sekikawa K
Biochem Genet. 2003
PubMed ID: 14974682
-
Identification of gp17 glycoprotein and characterization of prostatic acid phosphatase (PAP) and carboxypeptidase E (CPE) fragments in a human seminal plasma fraction interacting with concanavalin A.
Marquínez AC, Andreetta AM, González N, Wolfenstein-Todel C, Scacciati de Cerezo JM
J Protein Chem. 2003
PubMed ID: 14690244
-
Identification of cathepsin K as a novel marker of adiposity in white adipose tissue.
Chiellini C, Costa M, Novelli SE, Amri EZ, Benzi L, Bertacca A, Cohen P, Del Prato S, Friedman JM, Maffei M
J Cell Physiol. 2003
PubMed ID: 12652657
-
Biosynthesis and processing of pro CCK: recent progress and future challenges.
Beinfeld MC
Life Sci. 2003
PubMed ID: 12479974
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice.
Nillni EA, Xie W, Mulcahy L, Sanchez VC, Wetsel WC
J Biol Chem. 2002
PubMed ID: 12270926
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Developmental changes in opioid peptides and their receptors in Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E.
Boudarine M, Yegorov O, Sterling-Dubrovsky A, Devi LA, Berman Y
J Pharmacol Exp Ther. 2002
PubMed ID: 12438557
-
Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects.
Ramis JM, Franssen-van Hal NL, Kramer E, Llado I, Bouillaud F, Palou A, Keijer J
Cell Mol Life Sci. 2002
PubMed ID: 12530526
-
A quantitative trait locus that accounts for glucose intolerance maps to chromosome 8 in hereditary obese KK-A(y) mice.
Suto J, Sekikawa K
Int J Obes Relat Metab Disord. 2002
PubMed ID: 12439655
-
Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary.
Fan X, Olson SJ, Blevins LS, Allen GS, Johnson MD
J Histochem Cytochem. 2002
PubMed ID: 12417617
-
Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk.
Bouchard G, Johnson D, Carver T, Paigen B, Carey MC
J Lipid Res. 2002
PubMed ID: 12091495
-
Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity.
Pritchard LE, Turnbull AV, White A
J Endocrinol. 2002
PubMed ID: 11874690
-
ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.
Feng Y, Reznik SE, Fricker LD
Brain Res Gene Expr Patterns. 2002
PubMed ID: 15018810
-
Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice.
Che FY, Yan L, Li H, Mzhavia N, Devi LA, Fricker LD
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11481435
-
Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.
Chen H, Jawahar S, Qian Y, Duong Q, Chan G, Parker A, Meyer JM, Moore KJ, Chayen S, Gross DJ, Glaser B, Permutt MA, Fricker LD
Hum Mutat. 2001
PubMed ID: 11462236
-
Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice.
Friis-Hansen L, Lacourse KA, Samuelson LC, Holst JJ
J Endocrinol. 2001
PubMed ID: 11375130
-
Immunohistochemical localization and comparison of carboxypeptidases D, E, and Z, alpha-MSH, ACTH, and MIB-1 between human anterior and corticotroph cell "basophil invasion" of the posterior pituitary.
Fan X, Olson SJ, Johnson MD
J Histochem Cytochem. 2001
PubMed ID: 11373325
-
ProSAAS processing in mouse brain and pituitary.
Mzhavia N, Berman Y, Che FY, Fricker LD, Devi LA
J Biol Chem. 2001
PubMed ID: 11094058
-
The effects of aging on gene expression in the hypothalamus and cortex of mice.
Jiang CH, Tsien JZ, Schultz PG, Hu Y
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11172053
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice.
Berman Y, Mzhavia N, Polonskaia A, Devi LA
J Biol Chem. 2001
PubMed ID: 11038363
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Impaired feedback of gastric functions in carboxypeptidase E-deficient mice.
Friis-Hansen L, Rehfeld JF
Biochem Biophys Res Commun. 2000
PubMed ID: 10631115
-
Peptides, enzymes and obesity: new insights from a 'dead' enzyme.
Fricker LD, Leiter EH
Trends Biochem Sci. 1999
PubMed ID: 10500303
-
Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.
Berk PD, Zhou S, Kiang C, Stump DD, Fan X, Bradbury MW
J Biol Chem. 1999
PubMed ID: 10497230
-
Altered biosynthesis and secretion of pro-opiomelanocortin in the intermediate and anterior pituitary of carboxypeptidase E-deficient, Cpe(fat)/ Cpe(fat)mice.
Shen FS, Aguilera G, Loh YP
Neuropeptides. 1999
PubMed ID: 10657504
-
NIMA-related kinases: isolation and characterization of murine nek3 and nek4 cDNAs, and chromosomal localization of nek1, nek2 and nek3.
Chen A, Yanai A, Arama E, Kilfin G, Motro B
Gene. 1999
PubMed ID: 10393247
-
Genetics of human obesity: lessons from mouse models and candidate genes.
Echwald SM
J Intern Med. 1999
PubMed ID: 10395195
-
Genes involved in animal models of obesity and anorexia.
Schalling M, Johansen J, Nordfors L, Lönnqvist F
J Intern Med. 1999
PubMed ID: 10395190
-
Physiological and anatomical circuitry between Agouti-related protein and leptin signaling.
Wilson BD, Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ, Barsh GS
Endocrinology. 1999
PubMed ID: 10218993
-
Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function.
Gomez P, Hallberg L, Greeley GH
Proc Soc Exp Biol Med. 1999
PubMed ID: 9893169
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Test of candidate gene--quantitative trait locus association applied to fatness in mice.
Keightley PD, Morris KH, Ishikawa A, Falconer VM, Oliver F
Heredity. 1998
PubMed ID: 9885188
-
Immunohistochemical localization of carboxypeptidases E and D in the human placenta and umbilical cord.
Reznik SE, Salafia CM, Lage JM, Fricker LD
J Histochem Cytochem. 1998
PubMed ID: 9815277
-
Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain.
Wang W, Cain BM, Beinfeld MC
Endocrine. 1998
PubMed ID: 10221600
-
Altered processing of procholecystokinin in carboxypeptidase E-deficient fat mice: differential synthesis in neurons and endocrine cells.
Lacourse KA, Friis-Hansen L, Samuelson LC, Rehfeld JF
FEBS Lett. 1998
PubMed ID: 9771894
-
High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint.
Grewal PK, Bolland DJ, Todd LC, Hewitt JE
Mamm Genome. 1998
PubMed ID: 9680377
-
A common polygenic basis for quinine and PROP avoidance in mice.
Harder DB, Whitney G
Chem Senses. 1998
PubMed ID: 9669045
-
The molecular genetics of rodent single gene obesities.
Leibel RL, Chung WK, Chua SC
J Biol Chem. 1997
PubMed ID: 9405382
-
Mapping of eight testis-specific genes to mouse chromosomes.
Taketo MM, Araki Y, Matsunaga A, Yokoi A, Tsuchida J, Nishina Y, Nozaki M, Tanaka H, Koga M, Uchida K, Matsumiya K, Okuyama A, Rochelle JM, Nishimune Y, Matsui M, Seldin MF
Genomics. 1997
PubMed ID: 9403069
-
Carboxypeptidase E and obesity in the mouse.
Leiter EH
J Endocrinol. 1997
PubMed ID: 9415050
-
Disturbed progastrin processing in carboxypeptidase E-deficient fat mice.
Lacourse KA, Friis-Hansen L, Rehfeld JF, Samuelson LC
FEBS Lett. 1997
PubMed ID: 9369230
-
Cholecystokinin (CCK) levels are greatly reduced in the brains but not the duodenums of Cpe(fat)/Cpe(fat) mice: a regional difference in the involvement of carboxypeptidase E (Cpe) in pro-CCK processing.
Cain BM, Wang W, Beinfeld MC
Endocrinology. 1997
PubMed ID: 9275097
-
A new class of obesity genes encodes leukocyte adhesion receptors.
Dong ZM, Gutierrez-Ramos JC, Coxon A, Mayadas TN, Wagner DD
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207125
-
The genetics of obesity.
Naggert J, Harris T, North M
Curr Opin Genet Dev. 1997
PubMed ID: 9229117
-
Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation.
Shen FS, Loh YP
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9144234
-
Analysis of an expression profile of genes in the human adipose tissue.
Maeda K, Okubo K, Shimomura I, Mizuno K, Matsuzawa Y, Matsubara K
Gene. 1997
PubMed ID: 9197538
-
Effect of carboxypeptidase E deficiency on progastrin processing and gastrin messenger ribonucleic acid expression in mice with the fat mutation.
Udupi V, Gomez P, Song L, Varlamov O, Reed JT, Leiter EH, Fricker LD, Greeley GH
Endocrinology. 1997
PubMed ID: 9112393
-
The pro region is not required for the expression or intracellular routeing of carboxypeptidase E.
Song L, Fricker LD
Biochem J. 1997
PubMed ID: 9173892
-
Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice.
Cool DR, Normant E, Shen F, Chen HC, Pannell L, Zhang Y, Loh YP
Cell. 1997
PubMed ID: 9019408
-
Allele-specific PCR assays for the tub and cpefat mutations.
Maddatu T, Naggert JK
Mamm Genome. 1997
PubMed ID: 9337402
-
The biosynthetic processing and secretion of endogenous carboxypeptidase H in mouse pituitary cells.
Mains RE, Zhou A, Parkinson D
Ann N Y Acad Sci. 1996
PubMed ID: 8993389
-
Genetics of obesity: advances from rodent studies.
Chagnon YC, Bouchard C
Trends Genet. 1996
PubMed ID: 8973143
-
Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fat/fat mice.
Rovere C, Viale A, Nahon J, Kitabgi P
Endocrinology. 1996
PubMed ID: 8770919
-
Pharmacologic manipulation of ob expression in a dietary model of obesity.
Collins S, Surwit RS
J Biol Chem. 1996
PubMed ID: 8621612
-
The C-terminal region of carboxypeptidase E involved in membrane binding is distinct from the region involved with intracellular routing.
Varlamov O, Fricker LD
J Biol Chem. 1996
PubMed ID: 8626393
-
Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function.
O'Rahilly S, Gray H, Humphreys PJ, Krook A, Polonsky KS, White A, Gibson S, Taylor K, Carr C
N Engl J Med. 1995
PubMed ID: 7477119
-
Processing of procarboxypeptidase E into carboxypeptidase E occurs in secretory vesicles.
Song L, Fricker L
J Neurochem. 1995
PubMed ID: 7790890
-
Chewing the fat.
Keightley PD
Nat Genet. 1995
PubMed ID: 7663503
-
Genetic mapping of the glycine receptor alpha 3 subunit on mouse chromosome 8.
Kingsmore SF, Suh D, Seldin MF
Mamm Genome. 1994
PubMed ID: 7894176
-
Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
Nishina PM, Naggert JK, Verstuyft J, Paigen B
Metabolism. 1994
PubMed ID: 8177043
-
Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow.
Nishina PM, Lowe S, Wang J, Paigen B
Metabolism. 1994
PubMed ID: 8177042
-
Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.
Milatovich A, Bolger G, Michaeli T, Francke U
Somat Cell Mol Genet. 1994
PubMed ID: 8009369
-
Assignment of the human carboxypeptidase E (CPE) gene to chromosome 4.
Hall C, Manser E, Spurr NK, Lim L
Genomics. 1993
PubMed ID: 8449522
-
Morphologic analysis of enteric lesions in conventional and streptomycin-treated inbred C3H/HeN mice infected with Serpulina (Treponema) hyodysenteriae.
Mysore JV, Duhamel GE, Mathiesen MR
Lab Anim Sci. 1992
PubMed ID: 1316514
-
Structural characterization of the rat carboxypeptidase-E gene.
Jung YK, Kunczt CJ, Pearson RK, Dixon JE, Fricker LD
Mol Endocrinol. 1991
PubMed ID: 1770952
-
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro.
Manser E, Fernandez D, Loo L, Goh PY, Monfries C, Hall C, Lim L
Biochem J. 1990
PubMed ID: 2334405
-
Rat preprocarboxypeptidase H. Cloning, characterization, and sequence of the cDNA and regulation of the mRNA by corticotropin-releasing factor.
Rodríguez C, Brayton KA, Brownstein M, Dixon JE
J Biol Chem. 1989
PubMed ID: 2784437
-
Isolation and sequence analysis of cDNA for rat carboxypeptidase E [EC 3.4.17.10], a neuropeptide processing enzyme.
Fricker LD, Adelman JP, Douglass J, Thompson RC, von Strandmann RP, Hutton J
Mol Endocrinol. 1989
PubMed ID: 2725530
-
Enkephalin convertase: purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules.
Fricker LD, Snyder SH
Proc Natl Acad Sci U S A. 1982
PubMed ID: 6808517
Model Organism Phenotype Links
|
Relevant resources: