COPB1

Summary Top Help

Gene Description:

coatomer protein complex, subunit beta 1

Synonyms:

2610019B04Rik, Rack2, COPB, Copb1, COPB1

Orthologs:

Human COPB1 (protein-coding), Mouse Copb1 (protein-coding), Rat Copb1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 2

Linkage Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	508
Idd27	Mouse	chr7:86521272..127029671	40.51	634

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:14464986..14521573 (56.59 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:121359073..121398225 (39.15 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:172199676..172233765 (349 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for COPB1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for COPB1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 3

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 19

Publications from PubMed Top Help

Publications: 94

Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP.
Kim E, Hwang EM, Yarishkin O, Yoo JC, Kim D, Park N, Cho M, Lee YS, Sun CH, Yi GS, Yoo J, Kang D, Han J, Hong SG, Park JY
Biochem Biophys Res Commun. 2010
PubMed ID: 20362547
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly.
Chen X, Simon ES, Xiang Y, Kachman M, Andrews PC, Wang Y
J Biol Chem. 2010
PubMed ID: 20056612
Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.
Fenton RA, Komatsu S, Ikebe M, Shea LG, Dobson JG
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19525381
Novel Golgi protein, GoPro49, is a specific dental follicle marker.
Takatalo MS, Tummers M, Thesleff I, Rönnholm R
J Dent Res. 2009
PubMed ID: 19587158
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Early endosomes and endosomal coatomer are required for autophagy.
Razi M, Chan EY, Tooze SA
J Cell Biol. 2009
PubMed ID: 19364919
COPI complex is a regulator of lipid homeostasis.
Beller M, Sztalryd C, Southall N, Bell M, Jäckle H, Auld DS, Oliver B
PLoS Biol. 2008
PubMed ID: 19067489
Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic.
Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, Presley JF, McPherson PS
J Biol Chem. 2008
PubMed ID: 18556652
Depletion of beta-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1.
Styers ML, O'Connor AK, Grabski R, Cormet-Boyaka E, Sztul E
Am J Physiol Cell Physiol. 2008
PubMed ID: 18385291
COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro.
Tamayo AG, Bharti A, Trujillo C, Harrison R, Murphy JR
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18356299
HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.
Schaefer MR, Wonderlich ER, Roeth JF, Leonard JA, Collins KL
PLoS Pathog. 2008
PubMed ID: 18725938
Protein scaffolds, lipid domains and substrate recognition in protein kinase C function: implications for rational drug design.
Walker JW
Handb Exp Pharmacol. 2008
PubMed ID: 18491053
Copb1-facilitated axonal transport and translation of kappa opioid-receptor mRNA.
Bi J, Tsai NP, Lu HY, Loh HH, Wei LN
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17698811
Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP.
Sun Z, Anderl F, Fröhlich K, Zhao L, Hanke S, Brügger B, Wieland F, Béthune J
Traffic. 2007
PubMed ID: 17451557
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes.
Goryachev AB, Pokhilko AV
PLoS Comput Biol. 2006
PubMed ID: 17140284
Insights into COPI coat assembly and function in living cells.
Lippincott-Schwartz J, Liu W
Trends Cell Biol. 2006
PubMed ID: 16956762
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.
Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K, Sorimachi H
J Biol Chem. 2006
PubMed ID: 16476741
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
The LIFEdb database in 2006.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S
Nucleic Acids Res. 2006
PubMed ID: 16381901
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles.
Le-Niculescu H, Niesman I, Fischer T, DeVries L, Farquhar MG
J Biol Chem. 2005
PubMed ID: 15749703
Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.
Loh E, Peter F, Subramaniam VN, Hong W
J Cell Sci. 2005
PubMed ID: 15728249
From ORFeome to biology: a functional genomics pipeline.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A
Genome Res. 2004
PubMed ID: 15489336
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
ARF1 regulates Nef-induced CD4 degradation.
Fauré J, Stalder R, Borel C, Sobo K, Piguet V, Demaurex N, Gruenberg J, Trono D
Curr Biol. 2004
PubMed ID: 15202998
Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes.
Huang X, Walker JW
J Cell Sci. 2004
PubMed ID: 15039458
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
An essential function of tapasin in quality control of HLA-G molecules.
Park B, Ahn K
J Biol Chem. 2003
PubMed ID: 12582157
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Structural integrity of the Golgi stack is essential for normal secretory functions of rat parotid acinar cells: effects of brefeldin A and okadaic acid.
Tamaki H, Yamashina S
J Histochem Cytochem. 2002
PubMed ID: 12486083
Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals.
O'Kelly I, Butler MH, Zilberberg N, Goldstein SA
Cell. 2002
PubMed ID: 12437930
GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.
Xu Y, Martin S, James DE, Hong W
Mol Biol Cell. 2002
PubMed ID: 12388752
Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
Huang L, Feng L, Yang L, Zhou W, Zhao S, Li C
Mol Biol Rep. 2002
PubMed ID: 12463424
Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes.
Kanzaki M, Watson RT, Hou JC, Stamnes M, Saltiel AR, Pessin JE
Mol Biol Cell. 2002
PubMed ID: 12134073
PKC epsilon is associated with myosin IIA and actin in fibroblasts.
England K, Ashford D, Kidd D, Rumsby M
Cell Signal. 2002
PubMed ID: 11897493
Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum.
Paulsson KM, Kleijmeer MJ, Griffith J, Jevon M, Chen S, Anderson PO, Sjogren HO, Li S, Wang P
J Biol Chem. 2002
PubMed ID: 11884415
KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET.
Majoul I, Straub M, Hell SW, Duden R, Söling HD
Dev Cell. 2001
PubMed ID: 11703931
Structure--function relationships in HIV-1 Nef.
Geyer M, Fackler OT, Peterlin BM
EMBO Rep. 2001
PubMed ID: 11463741
Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.
Takatsu H, Futatsumori M, Yoshino K, Yoshida Y, Shin HW, Nakayama K
Biochem Biophys Res Commun. 2001
PubMed ID: 11409905
Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.
Janvier K, Craig H, Le Gall S, Benarous R, Guatelli J, Schwartz O, Benichou S
J Virol. 2001
PubMed ID: 11264386
Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A
Genome Res. 2001
PubMed ID: 11230166
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
DNA cloning using in vitro site-specific recombination.
Hartley JL, Temple GF, Brasch MA
Genome Res. 2000
PubMed ID: 11076863
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Identification and characterization of novel isoforms of COP I subunits.
Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K
J Biochem. 2000
PubMed ID: 11056392
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The debate about transport in the Golgi--two sides of the same coin?
Pelham HR, Rothman JE
Cell. 2000
PubMed ID: 11030615
RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
Sullivan BM, Harrison-Lavoie KJ, Marshansky V, Lin HY, Kehrl JH, Ausiello DA, Brown D, Druey KM
Mol Biol Cell. 2000
PubMed ID: 10982407
COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP.
Eugster A, Frigerio G, Dale M, Duden R
EMBO J. 2000
PubMed ID: 10921873
GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28.
Sagiv Y, Legesse-Miller A, Porat A, Elazar Z
EMBO J. 2000
PubMed ID: 10747018
Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles.
Fischer KD, Helms JB, Zhao L, Wieland FT
Methods. 2000
PubMed ID: 10720466
Secretory protein trafficking and organelle dynamics in living cells.
Lippincott-Schwartz J, Roberts TH, Hirschberg K
Annu Rev Cell Dev Biol. 2000
PubMed ID: 11031247
Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4.
Bogan JS, Lodish HF
J Cell Biol. 1999
PubMed ID: 10444069
GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5.
Claude A, Zhao BP, Kuziemsky CE, Dahan S, Berger SJ, Yan JP, Armold AD, Sullivan EM, Melançon P
J Cell Biol. 1999
PubMed ID: 10402461
A Rab2 mutant with impaired GTPase activity stimulates vesicle formation from pre-Golgi intermediates.
Tisdale EJ
Mol Biol Cell. 1999
PubMed ID: 10359600
GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23.
Zhao L, Helms JB, Brunner J, Wieland FT
J Biol Chem. 1999
PubMed ID: 10318838
cDNA sequence and mapping of the mouse Copb gene encoding the beta subunit of the COPI coatomer complex.
LI W, Elliott RW, Novak EK, Swank RT
Somat Cell Mol Genet. 1999
PubMed ID: 11441537
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.
Piguet V, Gu F, Foti M, Demaurex N, Gruenberg J, Carpentier JL, Trono D
Cell. 1999
PubMed ID: 10199403
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex.
Pavel J, Harter C, Wieland FT
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9482852
The coatomer protein beta'-COP, a selective binding protein (RACK) for protein kinase Cepsilon.
Csukai M, Chen CH, De Matteis MA, Mochly-Rosen D
J Biol Chem. 1997
PubMed ID: 9360998
Association of coatomer proteins with the beta-receptor for platelet-derived growth factor.
Hansen K, Rönnstrand L, Rorsman C, Hellman U, Heldin CH
Biochem Biophys Res Commun. 1997
PubMed ID: 9207175
Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes.
Mastick CC, Falick AL
Endocrinology. 1997
PubMed ID: 9165027
Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta.
Zhao L, Helms JB, Brügger B, Harter C, Martoglio B, Graf R, Brunner J, Wieland FT
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9114004
Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein.
Benichou S, Liu LX, Erdtmann L, Selig L, Benarous R
Res Virol. 1997
PubMed ID: 9017839
In vivo assembly of coatomer, the COP-I coat precursor.
Lowe M, Kreis TE
J Biol Chem. 1996
PubMed ID: 8940050
Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).
Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K
J Biochem. 1996
PubMed ID: 8947846
Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.
Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H
J Cell Biol. 1996
PubMed ID: 8858162
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes.
Aniento F, Gu F, Parton RG, Gruenberg J
J Cell Biol. 1996
PubMed ID: 8601610
Coat proteins and vesicle budding.
Schekman R, Orci L
Science. 1996
PubMed ID: 8599108
The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization.
Cukierman E, Huber I, Rotman M, Cassel D
Science. 1995
PubMed ID: 8533093
The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex.
Olivos-Glander IM, Jänne PA, Nussbaum RL
Am J Hum Genet. 1995
PubMed ID: 7573041
Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic.
Benichou S, Bomsel M, Bodéus M, Durand H, Douté M, Letourneur F, Camonis J, Benarous R
J Biol Chem. 1994
PubMed ID: 7982906
Beta-COP is essential for transport of protein from the endoplasmic reticulum to the Golgi in vitro.
Peter F, Plutner H, Zhu H, Kreis TE, Balch WE
J Cell Biol. 1993
PubMed ID: 8376457
Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol.
Orcl L, Palmer DJ, Amherdt M, Rothman JE
Nature. 1993
PubMed ID: 8355790
Beta-COP localizes mainly to the cis-Golgi side in exocrine pancreas.
Oprins A, Duden R, Kreis TE, Geuze HJ, Slot JW
J Cell Biol. 1993
PubMed ID: 8458872
Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein.
Donaldson JG, Kahn RA, Lippincott-Schwartz J, Klausner RD
Science. 1991
PubMed ID: 1957170
Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin.
Duden R, Griffiths G, Frank R, Argos P, Kreis TE
Cell. 1991
PubMed ID: 1840503
'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles.
Waters MG, Serafini T, Rothman JE
Nature. 1991
PubMed ID: 1898986

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1315	70349	114023
EnsEMBL Gene(s)	ENSG00000129083	ENSMUSG00000030754	ENSRNOG00000012000
Unigene	Hs.339278	Mm.277024	Rn.4327
Homologene	COPB1	Copb1	Copb1
OMIM	600959	N/A	N/A
GeneCards	COPB1	N/A	N/A
Beta Cell Genomics	DT.100663573 DT.100822940 DT.451536 DT.95108192 DT.95235278 DT.95235280	DT.101224670 DT.111003642 DT.87072683	N/A
Reactome	P53618	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1315	70349	114023

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
COPB1	TANK	IntAct	empirical	21988832
COPB1	HDAC5	BioGRID	empirical	21081666
COPB1	CFTR	IntAct	empirical	17110338
COPB1	KDELR1	HPRD, IntAct, BioGRID	empirical	11703931
COPB1	TMED10	IntAct	empirical	9472029
COPB1	IRAK3	IntAct	empirical	21988832
COPB1	COPE	HPRD, BioGRID, Reactome	empirical	10921873 8940050
COPB1	COPA	IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	20360068 10921873 8940050 15345047
COPB1	MAPK14	MINT, IntAct	empirical	15102471
COPB1	COPZ1	Reactome, Sanger Interaction Map	predicted	15345047
COPB1	COPG1	HPRD, BioGRID, Reactome, Sanger Interaction Map	empirical	11056392 8940050 15345047
COPB1	RHOQ	HPRD	empirical	12134073
COPB1	XRCC6	IntAct	empirical	21988832
COPB1	COPG2	HPRD, BioGRID	empirical	11409905 11056392
COPB1	FOXB1	IntAct	empirical	21988832
COPB1	GRB2	IntAct	empirical	21988832
COPB1	SERTAD1	IntAct	empirical	21988832
COPB1	HLA-A	BioGRID	empirical	11884415
COPB1	HLA-DPB1	IntAct	empirical	21988832
COPB1	HLA-G	HPRD, BioGRID	empirical	12582157
COPB1	ID1	IntAct	empirical	21988832
COPB1	ARCN1	HPRD, Reactome, Sanger Interaction Map	empirical	8940050 15345047
COPB1	ARF1	HPRD, BioGRID	empirical	10720466 10318838 10921873 15202998
COPB1	KCNK3	HPRD, BioGRID	empirical	12437930
COPB1	TRIM37	HPRD, MINT, IntAct, BioGRID	empirical	16189514
COPB1	PDGFRB	HPRD	empirical	9207175
COPB1	NUB1	IntAct	empirical	21988832
COPB1	TMED9	IntAct	empirical	9472029
COPB1	PRKCE	HPRD	empirical	11897493
COPB1	UBQLN4	HPRD, MINT, IntAct	empirical	16713569
COPB1	VPS18	IntAct	empirical	21988832
COPB1	RGS2	HPRD	empirical	10982407
COPB1	RGS4	HPRD	empirical	10982407
COPB1	BCR	MINT	empirical	15494376
COPB1	RYR2	MINT, IntAct	empirical	15102471
COPB1	SLC2A4	IntAct	empirical	16396496
COPB1	TAP1	BioGRID	empirical	11884415
COPB1	TAPBP	HPRD, BioGRID	empirical	11884415
COPB1	TNFRSF1B	MINT, IntAct	empirical	14743216
COPB1	UBC	BioGRID	empirical	16196087 21987572 21139048 21890473 21906983
COPB1	LZTS2	IntAct	empirical	21988832
COPB1	MAP1LC3A	IntAct	empirical	20562859
COPB1	ADAM19	BioGRID	empirical	12463424
COPB1	GBF1	MINT	empirical	19039328
COPB1	COPB2	BioGRID, Reactome, Sanger Interaction Map	empirical	10921873 8940050 15345047