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CCR3

Gene Description:   chemokine (C-C motif) receptor 3 Synonyms:   Cmkbr1l2, Ccr3, CMKBR3, Cmkbr3, CC-CKR3, MGC102841, MGC124266, CC-CKR-3, CKR3, CCR3, MGC124265, CD193 Orthologs:   Human CCR3 (protein-coding), Mouse Ccr3 (protein-coding), Rat Ccr3 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, KEGG Human-Rat: HomoloGene, MGD, RGD, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
3p21.31	Human	chr3:45980673..46654132	0.67	77	rs333 rs11711054

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 3p21.31 Orthologous Region	Mouse	chr9:123713859..124045161	0.33	9
Human 3p21.31 Orthologous Region	Rat	chr8:128563968..128916583	0.35	8

(Human) GRCh37 - chr3:46205096..46308197 (103.10 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr9:123936703..123946421 (9.72 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr8:128759943..128769341 (9.40 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for CCR3: The CCR3 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs CCR3   CCL26   HPRD  empirical  10488147  CCR3   CCR3   HPRD  empirical  12023397  CCR3   FGR   HPRD, BioGRID  empirical  10527858  CCR3   HCK   HPRD, BioGRID  empirical  10527858  CCR3   CXCL10   HPRD  empirical  11110785  CCR3   CXCL9   HPRD  empirical  11110785  CCR3   CCL2   BioGRID  empirical  8642344  CCR3   CCL3   HPRD  empirical  7594543  CCR3   CCL3L1   HPRD  empirical  11449371  CCR3   CCL4   HPRD  empirical  7622448  CCR3   CCL5   HPRD, BioGRID, Reactome  empirical  9289016  8642344  11449371  8639485  7642634  7622448  CCR3   CCL7   HPRD, BioGRID  empirical  8642344  CCR3   CCL8   HPRD  empirical  9005985  CCR3   CCL11   HPRD, BioGRID  empirical  9712872  8642344  8609214  8676064  CCR3   CCL13   HPRD  empirical  12149192  CCR3   CCL14   HPRD  empirical  11085751  CCR3   CCL15   HPRD  empirical  9346309  CCR3   CCL24   HPRD  empirical  12218106  CCR3   CXCL11   HPRD  empirical  11110785

View all

KEGG Network: 2   Chemokine signaling pathway Human - 4062 Mouse - 4062 Rat - 4062 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060

Biocarta: 4   CCR3 signaling in Eosinophils Human Mouse IL 5 Signaling Pathway Human Mouse Selective expression of chemokine receptors during T-cell polarization Human Mouse The Role of Eosinophils in the Chemokine Network of Allergy Human Mouse

Reactome: 7   Chemokine receptors bind chemokines REACT_15344 Class A/1 (Rhodopsin-like receptors) REACT_14828 G alpha (i) signalling events REACT_19231 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Peptide ligand-binding receptors REACT_14819 Signaling by GPCR REACT_14797

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 22   Positive regulation of endothelial cell proliferation GO:0001938 Mast cell chemotaxis GO:0002551 Signal transducer activity GO:0004871 Receptor activity GO:0004872 G-protein coupled receptor activity GO:0004930 Chemokine receptor activity GO:0004950 Extracellular space GO:0005615 Endosome GO:0005768 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Chemotaxis GO:0006935 Inflammatory response GO:0006954 Cellular defense response GO:0006968 Cell adhesion GO:0007155 G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 Elevation of cytosolic calcium ion concentration GO:0007204 Integral to membrane GO:0016021 C-C chemokine receptor activity GO:0016493 Interspecies interaction between organisms GO:0044419 Positive regulation of angiogenesis GO:0045766 Eosinophil chemotaxis GO:0048245 ERK1 and ERK2 cascade GO:0070371

	KEGG Network: 2 Chemokine signaling pathway Human - 4062 Mouse - 4062 Rat - 4062 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060
	Biocarta: 4 CCR3 signaling in Eosinophils Human Mouse IL 5 Signaling Pathway Human Mouse Selective expression of chemokine receptors during T-cell polarization Human Mouse The Role of Eosinophils in the Chemokine Network of Allergy Human Mouse
	Reactome: 7 Chemokine receptors bind chemokines REACT_15344 Class A/1 (Rhodopsin-like receptors) REACT_14828 G alpha (i) signalling events REACT_19231 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Peptide ligand-binding receptors REACT_14819 Signaling by GPCR REACT_14797
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 22 Positive regulation of endothelial cell proliferation GO:0001938 Mast cell chemotaxis GO:0002551 Signal transducer activity GO:0004871 Receptor activity GO:0004872 G-protein coupled receptor activity GO:0004930 Chemokine receptor activity GO:0004950 Extracellular space GO:0005615 Endosome GO:0005768 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Chemotaxis GO:0006935 Inflammatory response GO:0006954 Cellular defense response GO:0006968 Cell adhesion GO:0007155 G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 Elevation of cytosolic calcium ion concentration GO:0007204 Integral to membrane GO:0016021 C-C chemokine receptor activity GO:0016493 Interspecies interaction between organisms GO:0044419 Positive regulation of angiogenesis GO:0045766 Eosinophil chemotaxis GO:0048245 ERK1 and ERK2 cascade GO:0070371

Type 1 Diabetes Publications: 2

• Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.
  Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR study group, Worthington J, Thomson W
  Ann Rheum Dis. 2010
  PubMed ID: 20647273
   
  
• Newly identified genetic risk variants for celiac disease related to the immune response.
  Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA
  Nat Genet. 2008
  PubMed ID: 18311140
   
  

Publications: 206

• Pulmonary epithelial CCR3 promotes LPS-induced lung inflammation by mediating release of IL-8.
  Li B, Dong C, Wang G, Zheng H, Wang X, Bai C
  J Cell Physiol. 2011
  PubMed ID: 21660963
   
  
• CCL11-CCR3 interactions promote survival of anaplastic large cell lymphoma cells via ERK1/2 activation.
  Miyagaki T, Sugaya M, Murakami T, Asano Y, Tada Y, Kadono T, Okochi H, Tamaki K, Sato S
  Cancer Res. 2011
  PubMed ID: 21406396
   
  
• Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease.
  Fattouh R, Al-Garawi A, Fattouh M, Arias K, Walker TD, Goncharova S, Coyle AJ, Humbles AA, Jordana M
  Am J Respir Crit Care Med. 2011
  PubMed ID: 20732990
   
  
• CCR3 and choroidal neovascularization.
  Li Y, Huang D, Xia X, Wang Z, Luo L, Wen R
  PLoS One. 2011
  PubMed ID: 21358803
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Local proliferation and mobilization of CCR3(+)  CD34(+) eosinophil-lineage-committed cells in the lung.
  Rådinger M, Bossios A, Sjöstrand M, Lu Y, Malmhäll C, Dahlborn AK, Lee JJ, Lötvall J
  Immunology. 2011
  PubMed ID: 20875077
   
  
• The crucial role of GATA-1 in CCR3 gene transcription: modulated balance by multiple GATA elements in the CCR3 regulatory region.
  Kim BS, Uhm TG, Lee SK, Lee SH, Kang JH, Park CS, Chung IY
  J Immunol. 2010
  PubMed ID: 21041734
   
  
• Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.
  Fortin M, Wagner JG, Brault J, Harkema JR, Renzi PM, Paquet L, Ferrari N
  Cytokine. 2010
  PubMed ID: 20696593
   
  
• Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies.
  Manousou P, Kolios G, Valatas V, Drygiannakis I, Bourikas L, Pyrovolaki K, Koutroubakis I, Papadaki HA, Kouroumalis E
  Clin Exp Immunol. 2010
  PubMed ID: 21077277
   
  
• A large-scale candidate gene association study of age at menarche and age at natural menopause.
  He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
  Hum Genet. 2010
  PubMed ID: 20734064
   
  
• Didecyldimethylammonium chloride induces pulmonary inflammation and fibrosis in mice.
  Ohnuma A, Yoshida T, Tajima H, Fukuyama T, Hayashi K, Yamaguchi S, Ohtsuka R, Sasaki J, Fukumori J, Tomita M, Kojima S, Takahashi N, Takeuchi Y, Kuwahara M, Takeda M, Kosaka T, Nakashima N, Harada T
  Exp Toxicol Pathol. 2010
  PubMed ID: 19762220
   
  
• [The expression of periphery blood leucocyte CCR3 and CCR5 in the children with Epstein-Barr virus associated infectious mononucleosis].
  Qi TX, Gao GH, Liu SH
  Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2010
  PubMed ID: 21280323
   
  
• Lack of association between chemokine (C-C motif) receptor 3 (CCR3) gene and schizophrenia in the Korean population.
  Kim SK, Ban JY, Park HJ, Chung JH, Kim JW
  Psychiatry Clin Neurosci. 2010
  PubMed ID: 20923436
   
  
• Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma.
  Miyagaki T, Sugaya M, Fujita H, Ohmatsu H, Kakinuma T, Kadono T, Tamaki K, Sato S
  J Invest Dermatol. 2010
  PubMed ID: 20505746
   
  
• Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.
  Beckers MM, Ruven HJ, Haas FJ, Doevendans PA, ten Cate H, Prins MH, Biesma DH
  Eur J Intern Med. 2010
  PubMed ID: 20603037
   
  
• Decreased levels of CCR3 in CD4+ lymphocytes of rheumatoid arthritis patients.
  Aloush V, George J, Elkayam O, Wigler I, Oren S, Entin-Meer M, Maysel-Auslender S, Ablin JN
  Clin Exp Rheumatol. 2010
  PubMed ID: 20659406
   
  
• A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.
  Wise EL, Bonner KT, Williams TJ, Pease JE
  J Allergy Clin Immunol. 2010
  PubMed ID: 20541248
   
  
• Polymorphisms in innate immunity genes and risk of childhood leukemia.
  Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D
  Hum Immunol. 2010
  PubMed ID: 20438785
   
  
• Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
  Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
  Pediatr Pulmonol. 2010
  PubMed ID: 20503287
   
  
• Risk of meningioma and common variation in genes related to innate immunity.
  Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20406964
   
  
• Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease.
  Kim SH, Yang EM, Lee HN, Choi GS, Ye YM, Park HS
  Respir Med. 2010
  PubMed ID: 20022477
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Multiple common variants for celiac disease influencing immune gene expression.
  Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
  Nat Genet. 2010
  PubMed ID: 20190752
   
  
• Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
  Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
  Vaccine. 2010
  PubMed ID: 20056178
   
  
• Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy.
  Al-Abdulhadi SA, Al-Rabia MW
  Ann Saudi Med. 2010
  PubMed ID: 20220260
   
  
• Differential expression of Th2 chemokine receptors on T cells from atopic and nonatopic asthmatics in response to Der p 1-pulsed dendritic cells.
  Maneechotesuwan K, Wongkajornsilp A, Huabprasert S, Kasetsinsombat K, Suthumansami T
  J Med Assoc Thai. 2010
  PubMed ID: 20364559
   
  
• Effects of a dual CCR3 and H1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitis.
  Greiff L, Ahlström-Emanuelsson C, Bahl A, Bengtsson T, Dahlström K, Erjefält J, Widegren H, Andersson M
  Respir Res. 2010
  PubMed ID: 20144207
   
  
• A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice.
  Komai M, Tanaka H, Nagao K, Ishizaki M, Kajiwara D, Miura T, Ohashi H, Haba T, Kawakami K, Sawa E, Yoshie O, Inagaki N, Nagai H
  J Pharmacol Sci. 2010
  PubMed ID: 20134116
   
  
• The function of CCR3 on mouse bone marrow-derived mast cells in vitro.
  Collington SJ, Westwick J, Williams TJ, Weller CL
  Immunology. 2010
  PubMed ID: 20050333
   
  
• Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.
  McKee AS, Munks MW, MacLeod MK, Fleenor CJ, Van Rooijen N, Kappler JW, Marrack P
  J Immunol. 2009
  PubMed ID: 19734227
   
  
• CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) .
  Xu JH, Long L, Tang YC, Zhang JT, Hut HT, Tang FR
  Neuropathol Appl Neurobiol. 2009
  PubMed ID: 19490431
   
  
• Altered chemokine receptor expression in papillary thyroid cancer.
  González HE, Leiva A, Tobar H, Böhmwald K, Tapia G, Torres J, Mosso LM, Bueno SM, Gonzalez P, Kalergis AM, Riedel CA
  Thyroid. 2009
  PubMed ID: 19731977
   
  
• Nuclear autoantigen CENP-B transactivation of the epidermal growth factor receptor via chemokine receptor 3 in vascular smooth muscle cells.
  Robitaille G, Christin MS, Clément I, Senécal JL, Raymond Y
  Arthritis Rheum. 2009
  PubMed ID: 19714638
   
  
• Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype.
  Nedellec R, Coetzer M, Shimizu N, Hoshino H, Polonis VR, Morris L, Mårtensson UE, Binley J, Overbaugh J, Mosier DE
  J Virol. 2009
  PubMed ID: 19553323
   
  
• Association of IL18RAP and CCR3 with coeliac disease in the Spanish population.
  Dema B, Martínez A, Fernández-Arquero M, Maluenda C, Polanco I, de la Concha EG, Urcelay E, Núñez C
  J Med Genet. 2009
  PubMed ID: 19542083
   
  
• Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.
  Amundsen SS, Rundberg J, Adamovic S, Gudjónsdóttir AH, Ascher H, Ek J, Nilsson S, Lie BA, Naluai AT, Sollid LM
  Genes Immun. 2009
  PubMed ID: 19693089
   
  
• Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
  Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
  Eur Urol. 2009
  PubMed ID: 19692168
   
  
• Chemokine receptors in a regulation of interstitial lung fibrosis and inflammation.
  Sterclova M, Vasakova M, Pavlicek J, Metlicka M, Krasna E, Striz I
  Exp Lung Res. 2009
  PubMed ID: 19842835
   
  
• Interplay between signaling via the formyl peptide receptor (FPR) and chemokine receptor 3 (CCR3) in human eosinophils.
  Svensson L, Redvall E, Johnsson M, Stenfeldt AL, Dahlgren C, Wennerås C
  J Leukoc Biol. 2009
  PubMed ID: 19414538
   
  
• PTEN identified as important risk factor of chronic obstructive pulmonary disease.
  Hosgood HD, Menashe I, He X, Chanock S, Lan Q
  Respir Med. 2009
  PubMed ID: 19625176
   
  
• CCR3 is a target for age-related macular degeneration diagnosis and therapy.
  Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J
  Nature. 2009
  PubMed ID: 19525930
   
  
• A candidate gene association study of 77 polymorphisms in migraine.
  Schürks M, Kurth T, Buring JE, Zee RY
  J Pain. 2009
  PubMed ID: 19559392
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Common variation in genes related to innate immunity and risk of adult glioma.
  Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19423540
   
  
• Analyses of associations with asthma in four asthma population samples from Canada and Australia.
  Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Paré PD, Hudson TJ
  Hum Genet. 2009
  PubMed ID: 19247692
   
  
• Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
  Environ Mol Mutagen. 2009
  PubMed ID: 19170196
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
  Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
  Pediatr Infect Dis J. 2009
  PubMed ID: 19258923
   
  
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• Biological analysis of human immunodeficiency virus type 1 R5 envelopes amplified from brain and lymph node tissues of AIDS patients with neuropathology reveals two distinct tropism phenotypes and identifies envelopes in the brain that confer an enhanced
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• Eotaxin and monocyte chemotactic protein-3 use different modes of action.
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