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CCR1

Gene Description:   chemokine (C-C motif) receptor 1 Synonyms:   CKR1, HM145, MIP1aR, CCR1, Cmkbr1, SCYAR1, CKR-1, Mip-1a-R, CD191, Ccr1, CMKBR1 Orthologs:   Human CCR1 (protein-coding), Mouse Ccr1 (protein-coding), Rat Ccr1 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, OrthoMCL Human-Rat: HomoloGene, MGD, RGD, OrthoMCL Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
3p21.31	Human	chr3:45980673..46654132	0.67	77	rs333 rs11711054

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 3p21.31 Orthologous Region	Mouse	chr9:123713859..124045161	0.33	9
Human 3p21.31 Orthologous Region	Rat	chr8:128563968..128916583	0.35	8

(Human) GRCh37 - chr3:46243200..46249887 (6.69 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr9:123876959..123883525 (6.57 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr8:128693658..128699213 (5.55 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for CCR1: The CCR1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs CCR1   CCL26   HPRD  empirical  15039444  CCR1   CREB3   HPRD, IntAct  empirical  15001559  CCR1   CCR1   HPRD  empirical  10202040  CCR1   JAK1   HPRD  empirical  14674010  CCR1   PLP2   HPRD, IntAct  empirical  15474493  CCR1   CCL2   HPRD  empirical  8631787  CCR1   CCL3   HPRD  empirical  10660125  10202040  7545673  CCR1   CCL3L1   HPRD  empirical  11449371  CCR1   CCL4   HPRD  empirical  7594543  CCR1   CCL5   HPRD, BioGRID  empirical  9289016  11116158  14637022  12270118  7545673  11449371  CCR1   CCL7   HPRD, BioGRID  empirical  8530354  7545673  CCR1   CCL8   HPRD  empirical  9115216  CCR1   CCL14   HPRD  empirical  11085751  CCR1   CCL15   HPRD  empirical  9346309  CCR1   CCL16   HPRD, Reactome  empirical  11470772  10910894  7679328  8048929  9207005  CCR1   CCL23   HPRD, BioGRID  empirical  9558365  10660125  9886417  CCR1   STAT1   HPRD  empirical  14674010  CCR1   STAT3   HPRD  empirical  14674010  CCR1   TPST2   HPRD  empirical  17558413  CCR1   TPST1   HPRD  empirical  17558413  CCR1   GNA14   HPRD  empirical  8626727

View all

KEGG Network: 2   Chemokine signaling pathway Human - 4062 Mouse - 4062 Rat - 4062 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060

Biocarta: 1   Selective expression of chemokine receptors during T-cell polarization Human Mouse

Reactome: 7   Chemokine receptors bind chemokines REACT_15344 Class A/1 (Rhodopsin-like receptors) REACT_14828 G alpha (i) signalling events REACT_19231 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Peptide ligand-binding receptors REACT_14819 Signaling by GPCR REACT_14797

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 19   Dendritic cell chemotaxis GO:0002407 Signal transducer activity GO:0004871 Receptor activity GO:0004872 G-protein coupled receptor activity GO:0004930 Chemokine receptor activity GO:0004950 Protein binding GO:0005515 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Chemotaxis GO:0006935 Inflammatory response GO:0006954 Immune response GO:0006955 Cell adhesion GO:0007155 Cell surface receptor linked signaling pathway GO:0007166 G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 Elevation of cytosolic calcium ion concentration GO:0007204 Cell-cell signaling GO:0007267 Response to wounding GO:0009611 C-C chemokine receptor activity GO:0016493 Cytokine-mediated signaling pathway GO:0019221

	KEGG Network: 2 Chemokine signaling pathway Human - 4062 Mouse - 4062 Rat - 4062 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060
	Biocarta: 1 Selective expression of chemokine receptors during T-cell polarization Human Mouse
	Reactome: 7 Chemokine receptors bind chemokines REACT_15344 Class A/1 (Rhodopsin-like receptors) REACT_14828 G alpha (i) signalling events REACT_19231 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Peptide ligand-binding receptors REACT_14819 Signaling by GPCR REACT_14797
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 19 Dendritic cell chemotaxis GO:0002407 Signal transducer activity GO:0004871 Receptor activity GO:0004872 G-protein coupled receptor activity GO:0004930 Chemokine receptor activity GO:0004950 Protein binding GO:0005515 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Chemotaxis GO:0006935 Inflammatory response GO:0006954 Immune response GO:0006955 Cell adhesion GO:0007155 Cell surface receptor linked signaling pathway GO:0007166 G-protein signaling, coupled to cyclic nucleotide second messenger GO:0007187 Elevation of cytosolic calcium ion concentration GO:0007204 Cell-cell signaling GO:0007267 Response to wounding GO:0009611 C-C chemokine receptor activity GO:0016493 Cytokine-mediated signaling pathway GO:0019221

Type 1 Diabetes Publications: 2

• Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer.
  Ohri CM, Shikotra A, Green RH, Waller DA, Bradding P
  BMC Cancer. 2010
  PubMed ID: 20429924
   
  
• Newly identified genetic risk variants for celiac disease related to the immune response.
  Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA
  Nat Genet. 2008
  PubMed ID: 18311140
   
  

Publications: 204

• The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis.
  Yang X, Walton W, Cook DN, Hua X, Tilley S, Haskell CA, Horuk R, Blackstock AW, Kirby SL
  Am J Respir Cell Mol Biol. 2011
  PubMed ID: 20870892
   
  
• TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes.
  Fox JM, Letellier E, Oliphant CJ, Signoret N
  Blood. 2011
  PubMed ID: 21148810
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain.
  Kiguchi N, Kobayashi Y, Maeda T, Saika F, Kishioka S
  Neurosci Lett. 2010
  PubMed ID: 20692319
   
  
• A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens.
  Horn H, Pott C, Kalla J, Dreyling M, Rosenwald A, Ott G, Schwab M, Schaeffeler E
  Pharmacogenet Genomics. 2010
  PubMed ID: 20802378
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• The role of the CCR1 receptor in the inflammatory response to tobacco smoke in a mouse model.
  Onnervik PO, Lindahl M, Svitacheva N, Stämpfli M, Thim K, Smailagic A, Virtala R, Taylor JD
  Inflamm Res. 2010
  PubMed ID: 20387089
   
  
• Deficiency of chemokine receptor CCR1 causes osteopenia due to impaired functions of osteoclasts and osteoblasts.
  Hoshino A, Iimura T, Ueha S, Hanada S, Maruoka Y, Mayahara M, Suzuki K, Imai T, Ito M, Manome Y, Yasuhara M, Kirino T, Yamaguchi A, Matsushima K, Yamamoto K
  J Biol Chem. 2010
  PubMed ID: 20571024
   
  
• Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
  Chou RC, Kim ND, Sadik CD, Seung E, Lan Y, Byrne MH, Haribabu B, Iwakura Y, Luster AD
  Immunity. 2010
  PubMed ID: 20727790
   
  
• Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha.
  Iida N, Nakamoto Y, Baba T, Nakagawa H, Mizukoshi E, Naito M, Mukaida N, Kaneko S
  Cancer Res. 2010
  PubMed ID: 20663902
   
  
• Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model.
  Kitamura T, Fujishita T, Loetscher P, Revesz L, Hashida H, Kizaka-Kondoh S, Aoki M, Taketo MM
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20616008
   
  
• Polymorphisms in innate immunity genes and risk of childhood leukemia.
  Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D
  Hum Immunol. 2010
  PubMed ID: 20438785
   
  
• Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium.
  Huang J, Zhang Z, Guo J, Ni A, Deb A, Zhang L, Mirotsou M, Pratt RE, Dzau VJ
  Circ Res. 2010
  PubMed ID: 20378860
   
  
• Risk of meningioma and common variation in genes related to innate immunity.
  Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20406964
   
  
• Multiple common variants for celiac disease influencing immune gene expression.
  Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
  Nat Genet. 2010
  PubMed ID: 20190752
   
  
• Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice.
  Repeke CE, Ferreira SB, Claudino M, Silveira EM, de Assis GF, Avila-Campos MJ, Silva JS, Garlet GP
  Bone. 2010
  PubMed ID: 20053385
   
  
• Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
  Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
  Vaccine. 2010
  PubMed ID: 20056178
   
  
• C-C chemokine receptor 1 expression in human hematolymphoid neoplasia.
  Anderson MW, Zhao S, Ai WZ, Tibshirani R, Levy R, Lossos IS, Natkunam Y
  Am J Clin Pathol. 2010
  PubMed ID: 20154287
   
  
• No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients.
  Reuss R, Schreiber V, Klein A, Infante-Duarte C, Filippi M, Pabst W, Pohl C, Oschmann P
  Mult Scler. 2010
  PubMed ID: 20086017
   
  
• Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells.
  Salem ML, Al-Khami AA, El-Naggar SA, Díaz-Montero CM, Chen Y, Cole DJ
  J Immunol. 2010
  PubMed ID: 20083664
   
  
• Interaction between activated chemokine receptor 1 and FcepsilonRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells.
  Fifadara NH, Beer F, Ono S, Ono SJ
  Int Immunol. 2010
  PubMed ID: 20173038
   
  
• Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice.
  Guabiraba R, Marques RE, Besnard AG, Fagundes CT, Souza DG, Ryffel B, Teixeira MM
  PLoS One. 2010
  PubMed ID: 21206747
   
  
• Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
  Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
  PLoS One. 2010
  PubMed ID: 20634891
   
  
• CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.
  Ravindran C, Cheng YC, Liang SM
  Cell Immunol. 2010
  PubMed ID: 19883904
   
  
• CCR1-mediated activation of Nuclear Factor-kappaB in THP-1 monocytic cells involves Pertussis Toxin-insensitive Galpha(14) and Galpha(16) signaling cascades.
  Lee MM, Wong YH
  J Leukoc Biol. 2009
  PubMed ID: 19687291
   
  
• CC chemokine receptor-1 activates intimal smooth muscle-like cells in graft arterial disease.
  Shimizu K, Minami M, Shubiki R, Lopez-Ilasaca M, MacFarlane L, Asami Y, Li Y, Mitchell RN, Libby P
  Circulation. 2009
  PubMed ID: 19841301
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE) .
  Xu JH, Long L, Tang YC, Zhang JT, Hut HT, Tang FR
  Neuropathol Appl Neurobiol. 2009
  PubMed ID: 19490431
   
  
• Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner.
  Baba T, Nakamoto Y, Mukaida N
  J Immunol. 2009
  PubMed ID: 19675159
   
  
• Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.
  Amundsen SS, Rundberg J, Adamovic S, Gudjónsdóttir AH, Ascher H, Ek J, Nilsson S, Lie BA, Naluai AT, Sollid LM
  Genes Immun. 2009
  PubMed ID: 19693089
   
  
• [Correlations of chemokine receptor CCR1 expression with metastasis of lymph nodes in colorectal carcinoma tissues]
  Ma JA, Qiu ZH, Pei HP
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
  PubMed ID: 19664396
   
  
• CCR1 expression and signal transduction by murine BMMC results in secretion of TNF-alpha, TGFbeta-1 and IL-6.
  Fifadara NH, Aye CC, Raghuwanshi SK, Richardson RM, Ono SJ
  Int Immunol. 2009
  PubMed ID: 19592420
   
  
• Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28.
  Richter R, Casarosa P, Ständker L, Münch J, Springael JY, Nijmeijer S, Forssmann WG, Vischer HF, Vakili J, Detheux M, Parmentier M, Leurs R, Smit MJ
  J Immunol. 2009
  PubMed ID: 19553544
   
  
• CCR1 and CCR5 promote hepatic fibrosis in mice.
  Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF
  J Clin Invest. 2009
  PubMed ID: 19603542
   
  
• Common variation in genes related to innate immunity and risk of adult glioma.
  Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19423540
   
  
• CCR1 knockdown suppresses human non-small cell lung cancer cell invasion.
  Wang CL, Sun BS, Tang Y, Zhuang HQ, Cao WZ
  J Cancer Res Clin Oncol. 2009
  PubMed ID: 18972130
   
  
• Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma.
  Chang SJ, Wang TY, Tsai CY, Hu TF, Chang MD, Wang HW
  BMC Genomics. 2009
  PubMed ID: 20015385
   
  
• Chemokine receptor and ligand upregulation in the diaphragm during endotoxemia and Pseudomonas lung infection.
  Demoule A, Divangahi M, Yahiaoui L, Danialou G, Gvozdic D, Petrof BJ
  Mediators Inflamm. 2009
  PubMed ID: 19421418
   
  
• CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation.
  Camargo JF, Quinones MP, Mummidi S, Srinivas S, Gaitan AA, Begum K, Jimenez F, VanCompernolle S, Unutmaz D, Ahuja SS, Ahuja SK
  J Immunol. 2009
  PubMed ID: 19109148
   
  
• Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury.
  Furuichi K, Gao JL, Horuk R, Wada T, Kaneko S, Murphy PM
  J Immunol. 2008
  PubMed ID: 19050287
   
  
• MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.
  Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT
  PLoS Pathog. 2008
  PubMed ID: 19079579
   
  
• Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
  Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
  J Immunol. 2008
  PubMed ID: 19017998
   
  
• MIP-3alpha and MIP-1alpha rapidly mobilize dendritic cell precursors into the peripheral blood.
  He S, Cao Q, Yoneyama H, Ge H, Zhang Y, Zhang Y
  J Leukoc Biol. 2008
  PubMed ID: 18791167
   
  
• Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
  Kang SJ, Liang HE, Reizis B, Locksley RM
  Immunity. 2008
  PubMed ID: 19006696
   
  
• CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
  Wu Y, Li YY, Matsushima K, Baba T, Mukaida N
  J Immunol. 2008
  PubMed ID: 18941229
   
  
• Tumor cell apoptosis induces tumor-specific immunity in a CC chemokine receptor 1- and 5-dependent manner in mice.
  Iida N, Nakamoto Y, Baba T, Kakinoki K, Li YY, Wu Y, Matsushima K, Kaneko S, Mukaida N
  J Leukoc Biol. 2008
  PubMed ID: 18644849
   
  
• Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding.
  Jensen PC, Thiele S, Ulven T, Schwartz TW, Rosenkilde MM
  J Biol Chem. 2008
  PubMed ID: 18559339
   
  
• Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
  Luttrell LM
  Mol Biotechnol. 2008
  PubMed ID: 18240029
   
  
• Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.
  Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, Matsushima K
  Blood. 2008
  PubMed ID: 18375791
   
  
• Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression.
  LaCasse RA, Striebel JF, Favara C, Kercher L, Chesebro B
  J Neuroimmunol. 2008
  PubMed ID: 18396336
   
  
• Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction.
  Liehn EA, Merx MW, Postea O, Becher S, Djalali-Talab Y, Shagdarsuren E, Kelm M, Zernecke A, Weber C
  J Cell Mol Med. 2008
  PubMed ID: 18088392
   
  
• A key role for CC chemokine receptor 1 in T-cell-mediated respiratory inflammation.
  Schaller MA, Kallal LE, Lukacs NW
  Am J Pathol. 2008
  PubMed ID: 18202190
   
  
• Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
  Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Létuvée S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
  J Immunol. 2008
  PubMed ID: 18178867
   
  
• Essential contribution of CCL3 to alkali-induced corneal neovascularization by regulating vascular endothelial growth factor production by macrophages.
  Lu P, Li L, Wu Y, Mukaida N, Zhang X
  Mol Vis. 2008
  PubMed ID: 18776949
   
  
• Dissociation of heterotrimeric g proteins in cells.
  Lambert NA
  Sci Signal. 2008
  PubMed ID: 18577758
   
  
• Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.
  Quinones MP, Kalkonde Y, Estrada CA, Jimenez F, Ramirez R, Mahimainathan L, Mummidi S, Choudhury GG, Martinez H, Adams L, Mack M, Reddick RL, Maffi S, Haralambous S, Probert L, Ahuja SK, Ahuja SS
  Mol Cell Neurosci. 2008
  PubMed ID: 17949991
   
  
• Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells.
  Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 18087045
   
  
• CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system.
  Hickey MJ, Held KS, Baum E, Gao JL, Murphy PM, Lane TE
  Viral Immunol. 2007
  PubMed ID: 18158733
   
  
• Dual role of CCL3/CCR1 in oral squamous cell carcinoma: implications in tumor metastasis and local host defense.
  Silva TA, Ribeiro FL, Oliveira-Neto HH, Watanabe S, Alencar Rde C, Fukada SY, Cunha FQ, Leles CR, Mendonça EF, Batista AC
  Oncol Rep. 2007
  PubMed ID: 17914560
   
  
• CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation.
  Choi SW, Hildebrandt GC, Olkiewicz KM, Hanauer DA, Chaudhary MN, Silva IA, Rogers CE, Deurloo DT, Fisher JM, Liu C, Adams D, Chensue SW, Cooke KR
  Blood. 2007
  PubMed ID: 17641205
   
  
• CCR1 and CCR5 chemokine receptors are involved in fever induced by LPS (E. coli) and RANTES in rats.
  Machado RR, Soares DM, Proudfoot AE, Souza GE
  Brain Res. 2007
  PubMed ID: 17604006
   
  
• Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils.
  Sun J, Ramnath RD, Bhatia M
  Am J Physiol Cell Physiol. 2007
  PubMed ID: 17494633
   
  
• Determination of the sites of tyrosine O-sulfation in peptides and proteins.
  Yu Y, Hoffhines AJ, Moore KL, Leary JA
  Nat Methods. 2007
  PubMed ID: 17558413
   
  
• RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes.
  Morrison PT, Thomas LH, Sharland M, Friedland JS
  J Leukoc Biol. 2007
  PubMed ID: 17389578
   
  
• Expression of the chemokine receptor CCR1 in human renal allografts.
  Mayer V, Hudkins KL, Heller F, Schmid H, Kretzler M, Brandt U, Anders HJ, Regele H, Nelson PJ, Alpers CE, Schlöndorff D, Segerer S
  Nephrol Dial Transplant. 2007
  PubMed ID: 17298994
   
  
• Role of human LZIP in differential activation of the NF-kappaB pathway that is induced by CCR1-dependent chemokines.
  Jang SW, Kim YS, Lee YH, Ko J
  J Cell Physiol. 2007
  PubMed ID: 17192849
   
  
• p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells.
  Ko J, Yun CY, Lee JS, Kim JH, Kim IS
  Exp Mol Med. 2007
  PubMed ID: 17464174
   
  
• Downregulation of CCR1 inhibits human hepatocellular carcinoma cell invasion.
  Wu X, Fan J, Wang X, Zhou J, Qiu S, Yu Y, Liu Y, Tang Z
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17336272
   
  
• SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion.
  Kitamura T, Kometani K, Hashida H, Matsunaga A, Miyoshi H, Hosogi H, Aoki M, Oshima M, Hattori M, Takabayashi A, Minato N, Taketo MM
  Nat Genet. 2007
  PubMed ID: 17369830
   
  
• Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival.
  Hamrah P, Yamagami S, Liu Y, Zhang Q, Vora SS, Lu B, Gerard CJ, Dana MR
  Invest Ophthalmol Vis Sci. 2007
  PubMed ID: 17325167
   
  
• Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.
  Ishida Y, Kimura A, Kondo T, Hayashi T, Ueno M, Takakura N, Matsushima K, Mukaida N
  Am J Pathol. 2007
  PubMed ID: 17322370
   
  
• Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice.
  Braunersreuther V, Zernecke A, Arnaud C, Liehn EA, Steffens S, Shagdarsuren E, Bidzhekov K, Burger F, Pelli G, Luckow B, Mach F, Weber C
  Arterioscler Thromb Vasc Biol. 2007
  PubMed ID: 17138939
   
  
• Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE.
  Eltayeb S, Berg AL, Lassmann H, Wallström E, Nilsson M, Olsson T, Ericsson-Dahlstrand A, Sunnemark D
  J Neuroinflammation. 2007
  PubMed ID: 17484785
   
  
• Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis.
  Nakamura H, Higashikawa F, Nobukuni Y, Miyagawa K, Endo T, Imai T, Hatta K, Ozasa K, Motohashi Y, Matsuzaki I, Sasahara S, Ogino K, Akimaru K, Eboshida A
  Int Arch Allergy Immunol. 2007
  PubMed ID: 17135764
   
  
• A novel CCR5/CXCR3 antagonist protects intestinal ischemia/reperfusion injury.
  Akahori T, Sho M, Kashizuka H, Nomi T, Kanehiro H, Nakajima Y
  Transplant Proc. 2006
  PubMed ID: 17175273
   
  
• Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145.
  Akashi T, Koizumi K, Nagakawa O, Fuse H, Saiki I
  Oncol Rep. 2006
  PubMed ID: 16969502
   
  
• Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation.
  Vaidehi N, Schlyer S, Trabanino RJ, Floriano WB, Abrol R, Sharma S, Kochanny M, Koovakat S, Dunning L, Liang M, Fox JM, de Mendonça FL, Pease JE, Goddard WA, Horuk R
  J Biol Chem. 2006
  PubMed ID: 16837468
   
  
• Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10.
  Zernecke A, Liehn EA, Gao JL, Kuziel WA, Murphy PM, Weber C
  Blood. 2006
  PubMed ID: 16467202
   
  
• The multiple personalities of the chemokine receptor CCR7 in dendritic cells.
  Sánchez-Sánchez N, Riol-Blanco L, Rodríguez-Fernández JL
  J Immunol. 2006
  PubMed ID: 16621978
   
  
• Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.
  Yang X, Lu P, Fujii C, Nakamoto Y, Gao JL, Kaneko S, Murphy PM, Mukaida N
  Int J Cancer. 2006
  PubMed ID: 16284949
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection.
  Miller AL, Gerard C, Schaller M, Gruber AD, Humbles AA, Lukacs NW
  J Immunol. 2006
  PubMed ID: 16456018
   
  
• Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model.
  Menu E, De Leenheer E, De Raeve H, Coulton L, Imanishi T, Miyashita K, Van Valckenborgh E, Van Riet I, Van Camp B, Horuk R, Croucher P, Vanderkerken K
  Clin Exp Metastasis. 2006
  PubMed ID: 17086356
   
  
• Treatment with Met-RANTES decreases bacterial translocation in experimental colitis.
  Kucuk C, Sozuer E, Gursoy S, Canoz O, Artis T, Akcan A, Akyildiz H, Muhtaroglu S
  Am J Surg. 2006
  PubMed ID: 16399111
   
  
• CCR1 acts downstream of NFAT2 in osteoclastogenesis and enhances cell migration.
  Ishida N, Hayashi K, Hattori A, Yogo K, Kimura T, Takeya T
  J Bone Miner Res. 2006
  PubMed ID: 16355273
   
  
• Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection.
  Shrestha S, Strathdee SA, Galai N, Oleksyk T, Fallin MD, Mehta S, Schaid D, Vlahov D, O'Brien SJ, Smith MW
  J Infect Dis. 2006
  PubMed ID: 16323127
   
  
• Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue.
  Reichel CA, Khandoga A, Anders HJ, Schlöndorff D, Luckow B, Krombach F
  J Leukoc Biol. 2006
  PubMed ID: 16275892
   
  
• CCR5Delta32 polymorphism effects on CCR5 expression, patterns of immunopathology and disease course in multiple sclerosis.
  Kantarci OH, Morales Y, Ziemer PA, Hebrink DD, Mahad DJ, Atkinson EJ, Achenbach SJ, De Andrade M, Mack M, Ransohoff RM, Lassmann H, Bruck W, Weinshenker BG, Lucchinetti CF
  J Neuroimmunol. 2005
  PubMed ID: 16182378
   
  
• Differential CCR1-mediated chemotaxis signaling induced by human CC chemokine HCC-4/CCL16 in HOS cells.
  Kim IS, Jang SW, Sung HJ, Lee JS, Ko J
  FEBS Lett. 2005
  PubMed ID: 16226254
   
  
• Functional expression of CCL6 by rat microglia: a possible role of CCL6 in cell-cell communication.
  Kanno M, Suzuki S, Fujiwara T, Yokoyama A, Sakamoto A, Takahashi H, Imai Y, Tanaka J
  J Neuroimmunol. 2005
  PubMed ID: 16087246
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons.
  Lieberam I, Agalliu D, Nagasawa T, Ericson J, Jessell TM
  Neuron. 2005
  PubMed ID: 16129397
   
  
• Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2.
  Ank N, Petersen K, Malmgaard L, Mogensen SC, Paludan SR
  J Virol. 2005
  PubMed ID: 16014944
   
  
• Chemokine receptor CCR1: a new target for progressive kidney disease.
  Ninichuk V, Anders HJ
  Am J Nephrol. 2005
  PubMed ID: 16088077
   
  
• MIP-1alpha[CCL3] acting on the CCR1 receptor mediates neutrophil migration in immune inflammation via sequential release of TNF-alpha and LTB4.
  Ramos CD, Canetti C, Souto JT, Silva JS, Hogaboam CM, Ferreira SH, Cunha FQ
  J Leukoc Biol. 2005
  PubMed ID: 15831559
   
  
• Role of Rho family GTPases in CCR1- and CCR5-induced actin reorganization in macrophages.
  Di Marzio P, Dai WW, Franchin G, Chan AY, Symons M, Sherry B
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15882964
   
  
• Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis.
  Hwang J, Son KN, Kim CW, Ko J, Na DS, Kwon BS, Gho YS, Kim J
  Cytokine. 2005
  PubMed ID: 15927850
   
  
• Expression and regulation of CCR1 in peritoneal macrophages from women with and without endometriosis.
  Wieser F, Dogan S, Klingel K, Diedrich K, Taylor RN, Hornung D
  Fertil Steril. 2005
  PubMed ID: 15950672
   
  
• CCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium.
  Yamagami S, Hamrah P, Miyamoto K, Miyazaki D, Dekaris I, Dawson T, Lu B, Gerard C, Dana MR
  Invest Ophthalmol Vis Sci. 2005
  PubMed ID: 15790880
   
  
• Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease.
  Ninichuk V, Gross O, Reichel C, Khandoga A, Pawar RD, Ciubar R, Segerer S, Belemezova E, Radomska E, Luckow B, Perez de Lema G, Murphy PM, Gao JL, Henger A, Kretzler M, Horuk R, Weber M, Krombach F, Schlöndorff D, Anders HJ
  J Am Soc Nephrol. 2005
  PubMed ID: 15716328
   
  
• MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells.
  Oba Y, Lee JW, Ehrlich LA, Chung HY, Jelinek DF, Callander NS, Horuk R, Choi SJ, Roodman GD
  Exp Hematol. 2005
  PubMed ID: 15730850
   
  
• Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.
  de Mendonça FL, da Fonseca PC, Phillips RM, Saldanha JW, Williams TJ, Pease JE
  J Biol Chem. 2005
  PubMed ID: 15548526
   
  
• The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B.
  Zhang H, Meng F, Chu CL, Takai T, Lowell CA
  Immunity. 2005
  PubMed ID: 15723811
   
  
• Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice.
  Potteaux S, Combadière C, Esposito B, Casanova S, Merval R, Ardouin P, Gao JL, Murphy PM, Tedgui A, Mallat Z
  Mol Med. 2005
  PubMed ID: 16491201
   
  
• Gene and alternative splicing annotation with AIR.
  Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
  Genome Res. 2005
  PubMed ID: 15632090
   
  
• Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses.
  John AE, Gerard CJ, Schaller M, Miller AL, Berlin AA, Humbles AA, Lukacs NW
  Eur J Immunol. 2005
  PubMed ID: 15593301
   
  
• CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis.
  Ness TL, Carpenter KJ, Ewing JL, Gerard CJ, Hogaboam CM, Kunkel SL
  J Immunol. 2004
  PubMed ID: 15557190
   
  
• CCR1 chemokines promote the chemotactic recruitment, RANKL development, and motility of osteoclasts and are induced by inflammatory cytokines in osteoblasts.
  Yu X, Huang Y, Collin-Osdoby P, Osdoby P
  J Bone Miner Res. 2004
  PubMed ID: 15537451
   
  
• Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production.
  Yanaba K, Mukaida N, Matsushima K, Murphy PM, Takehara K, Sato S
  Eur J Immunol. 2004
  PubMed ID: 15517609
   
  
• PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells.
  Lee SM, Shin H, Jang SW, Shim JJ, Song IS, Son KN, Hwang J, Shin YH, Kim HH, Lee CK, Ko J, Na DS, Kwon BS, Kim J
  Biochem Biophys Res Commun. 2004
  PubMed ID: 15474493
   
  
• Impact of engagement of FcepsilonRI and CC chemokine receptor 1 on mast cell activation and motility.
  Toda M, Dawson M, Nakamura T, Munro PM, Richardson RM, Bailly M, Ono SJ
  J Biol Chem. 2004
  PubMed ID: 15337751
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Impaired lung dendritic cell activation in CCR2 knockout mice.
  Chiu BC, Freeman CM, Stolberg VR, Hu JS, Zeibecoglou K, Lu B, Gerard C, Charo IF, Lira SA, Chensue SW
  Am J Pathol. 2004
  PubMed ID: 15466386
   
  
• Functional antagonism of chemokine receptor CCR1 reduces mortality in acute pneumovirus infection in vivo.
  Bonville CA, Lau VK, DeLeon JM, Gao JL, Easton AJ, Rosenberg HF, Domachowske JB
  J Virol. 2004
  PubMed ID: 15254170
   
  
• Effects of chemokines on proliferation and apoptosis of human mesangial cells.
  Wörnle M, Schmid H, Merkle M, Banas B
  BMC Nephrol. 2004
  PubMed ID: 15265234
   
  
• Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice.
  Anders HJ, Belemezova E, Eis V, Segerer S, Vielhauer V, Perez de Lema G, Kretzler M, Cohen CD, Frink M, Horuk R, Hudkins KL, Alpers CE, Mampaso F, Schlöndorff D
  J Am Soc Nephrol. 2004
  PubMed ID: 15153561
   
  
• Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role.
  Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B
  J Biol Chem. 2004
  PubMed ID: 15039444
   
  
• Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.
  Ko J, Jang SW, Kim YS, Kim IS, Sung HJ, Kim HH, Park JY, Lee YH, Kim J, Na DS
  FASEB J. 2004
  PubMed ID: 15001559
   
  
• Reduced expression of the chemokine receptor CCR1 in human macrophages and U-937 cells in vitro infected with Leishmania infantum.
  Panaro MA, Spinelli R, Lisi S, Sisto M, Acquafredda A, Fumarola L, Mitolo V, Brandonisio O
  Clin Exp Med. 2004
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• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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• Blocking CC chemokine receptor (CCR) 1 and CCR5 during herpes simplex virus type 2 infection in vivo impairs host defence and perturbs the cytokine response.
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• Combined blockade of the chemokine receptors CCR1 and CCR5 attenuates chronic rejection.
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• Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice.
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• HIV-1 infection and chemokine receptor modulation.
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• CCR1 is an early and specific marker of Alzheimer's disease.
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• Trophoblasts acquire a chemokine receptor, CCR1, as they differentiate towards invasive phenotype.
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• Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages.
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• CCL9 is secreted by the follicle-associated epithelium and recruits dome region Peyer's patch CD11b+ dendritic cells.
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• Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium.
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• Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter.
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• Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas.
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• CC chemokine receptor 1 enhances susceptibility to Leishmania major during early phase of infection.
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• Structure function differences in nonpeptide CCR1 antagonists for human and mouse CCR1.
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• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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• Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.
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• Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4.
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• Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.
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• Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection.
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• Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats.
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• Truncation of NH2-terminal amino acid residues increases agonistic potency of leukotactin-1 on CC chemokine receptors 1 and 3.
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• Chemokine/chemokine receptor nomenclature.
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• Chondroitin sulfate A released from platelets blocks RANTES presentation on cell surfaces and RANTES-dependent firm adhesion of leukocytes.
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• Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice.
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• CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclasts.
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• Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives.
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  AIDS Res Hum Retroviruses. 2002
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• Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes.
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• RANTES-induced chemokine cascade in dendritic cells.
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• Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils.
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• The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity.
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• CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness).
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• Functional annotation of a full-length mouse cDNA collection.
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• Mice lacking the chemokine receptor CCR1 show increased susceptibility to Toxoplasma gondii infection.
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• A study on the density and distribution of uterine Natural Killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1 alpha.
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• Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets.
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• Chemokine receptor 1 knockout abrogates natural killer cell recruitment and impairs type-1 cytokines in lymphoid tissue during pulmonary granuloma formation.
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• MIP-1alpha is produced but it does not control pulmonary inflammation in response to respiratory syncytial virus infection in mice.
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• Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties.
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• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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• Identification and characterization of a rat macrophage inflammatory protein-1alpha receptor.
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• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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• The chemokine macrophage-inflammatory protein-1 alpha and its receptor CCR1 control pulmonary inflammation and antiviral host defense in paramyxovirus infection.
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• Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle.
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• Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent.
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• LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8.
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• Airway remodeling is absent in CCR1-/- mice during chronic fungal allergic airway disease.
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• CCR2+ and CCR5+ CD8+ T cells increase during viral infection and migrate to sites of infection.
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• Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1).
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• Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection.
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• Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5.
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