Home LRRK2
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Regions Overlapping this Feature:
Rat: 1
Other Regions: 1 Available
Other Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm34 | Rat | chr7:96517746..137757704 | 41.24 | 447 |
(Human) GRCh37 - chr12:40590546..40763087 (172.54 kb) View in Genome Browser
(Mouse) NCBIM37 - chr15:91503606..91646555 (142.95 kb) View in Genome Browser
(Rat) RGSC3.4 - chr7:130105902..130268203 (162.30 kb) View in Genome Browser
HaemAtlas Expression Table for LRRK2:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | no data | no data | no data | no data | |||||||
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for LRRK2:The LRRK2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| LRRK2 | ARPC5 | IntAct | empirical | 20876399 |
| LRRK2 | ARPC4 | IntAct | empirical | 20876399 |
| LRRK2 | ARPC1B | IntAct | empirical | 20876399 |
| LRRK2 | ACTR3 | IntAct | empirical | 20876399 |
| LRRK2 | ACTR2 | IntAct | empirical | 20876399 |
| LRRK2 | ARPC2 | IntAct | empirical | 20876399 |
| LRRK2 | STUB1 | BioGRID | empirical | 19196961 19536328 |
| LRRK2 | MYL12B | IntAct | empirical | 20876399 |
| LRRK2 | ATP5L | IntAct | empirical | 20876399 |
| LRRK2 | STX1B | IntAct | empirical | 21307259 |
| LRRK2 | CLTC | IntAct | empirical | 21307259 |
| LRRK2 | CSE1L | IntAct | empirical | 21983832 |
| LRRK2 | AP2A1 | IntAct | empirical | 21307259 |
| LRRK2 | AP2A2 | IntAct | empirical | 21307259 |
| LRRK2 | AP1B1 | IntAct | empirical | 21307259 |
| LRRK2 | DBN1 | IntAct | empirical | 20876399 |
| LRRK2 | AP2B1 | IntAct | empirical | 21307259 |
| LRRK2 | DNM1 | IntAct | empirical | 21307259 |
| LRRK2 | MPRIP | IntAct | empirical | 20876399 |
| LRRK2 | BRP44 | IntAct | empirical | 20876399 |
| LRRK2 | RAI14 | IntAct | empirical | 20876399 |
| LRRK2 | GNAI2 | IntAct | empirical | 20876399 |
| LRRK2 | TMOD3 | IntAct | empirical | 20876399 |
| LRRK2 | HSP90AA1 | BioGRID | empirical | 19536328 |
| LRRK2 | ACTBL2 | IntAct | empirical | 20876399 |
| LRRK2 | TNPO1 | IntAct | empirical | 21983832 |
| LRRK2 | MYO1B | IntAct | empirical | 20876399 |
| LRRK2 | MYO1F | IntAct | empirical | 20876399 |
| LRRK2 | MYL6 | IntAct | empirical | 20876399 |
| LRRK2 | MYO1C | IntAct | empirical | 20876399 |
| LRRK2 | MYO1D | IntAct | empirical | 20876399 |
| LRRK2 | PPP1R12A | IntAct | empirical | 20876399 |
| LRRK2 | NFATC2 | IntAct | empirical | 21983832 |
| LRRK2 | NSF | IntAct | empirical | 21307259 |
| LRRK2 | PARK2 | IntAct, BioGRID | empirical | 16352719 |
| LRRK2 | LIMA1 | IntAct | empirical | 20876399 |
| LRRK2 | PLEC | IntAct | empirical | 20876399 |
| LRRK2 | PPP2R1A | IntAct | empirical | 21983832 |
| LRRK2 | PSMD11 | IntAct | empirical | 21983832 |
| LRRK2 | ACTB | IntAct | empirical | 20876399 |
| LRRK2 | STX1A | IntAct | empirical | 21307259 |
| LRRK2 | SYN1 | IntAct | empirical | 21307259 |
| LRRK2 | ACTG1 | IntAct | empirical | 20876399 |
| LRRK2 | TPM1 | IntAct | empirical | 20876399 |
| LRRK2 | TPM2 | IntAct | empirical | 20876399 |
| LRRK2 | TPM3 | IntAct | empirical | 20876399 |
| LRRK2 | ACTG2 | IntAct | empirical | 21307259 |
| LRRK2 | UBC | BioGRID | empirical | 19536328 |
| LRRK2 | EFHD2 | IntAct | empirical | 20876399 |
| LRRK2 | CAPZA2 | IntAct | empirical | 20876399 |
| LRRK2 | CAPZB | IntAct | empirical | 20876399 |
| LRRK2 | CADPS | IntAct | empirical | 21307259 |
| LRRK2 | IQGAP1 | IntAct | empirical | 21983832 |
| LRRK2 | SNAP91 | IntAct | empirical | 21307259 |
| LRRK2 | SV2A | IntAct | empirical | 21307259 |
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Publications: 436
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Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells.
Pons B, Armengol G, Livingstone M, López L, Coch L, Sonenberg N, Ramón y Cajal S
Oncol Rep. 2012
PubMed ID: 21922152
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LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study.
Sharma S, Bandopadhyay R, Lashley T, Renton AE, Kingsbury AE, Kumaran R, Kallis C, Vilariño-Güell C, O'Sullivan SS, Lees AJ, Revesz T, Wood NW, Holton JL
Neuropathol Appl Neurobiol. 2011
PubMed ID: 21696411
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Clinical and brain imaging characteristics in leucine-rich repeat kinase 2-associated PD and asymptomatic mutation carriers.
Brockmann K, Gröger A, Di Santo A, Liepelt I, Schulte C, Klose U, Maetzler W, Hauser AK, Hilker R, Gomez-Mancilla B, Berg D, Gasser T
Mov Disord. 2011
PubMed ID: 21989859
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The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease.
Liu Z, Lee J, Krummey S, Lu W, Cai H, Lenardo MJ
Nat Immunol. 2011
PubMed ID: 21983832
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Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.
Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA
Biochemistry. 2011
PubMed ID: 21961647
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High frequency and reduced penetrance of LRRK2 G2019S mutation among Parkinson's disease patients in Cantabria (Spain).
Sierra M, González-Aramburu I, Sánchez-Juan P, Sánchez-Quintana C, Polo JM, Berciano J, Combarros O, Infante J
Mov Disord. 2011
PubMed ID: 21954089
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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.
Herzig MC, Kolly C, Persohn E, Theil D, Schweizer T, Hafner T, Stemmelen C, Troxler TJ, Schmid P, Danner S, Schnell CR, Mueller M, Kinzel B, Grevot A, Bolognani F, Stirn M, Kuhn RR, Kaupmann K, van der Putten PH, Rovelli G, Shimshek DR
Hum Mol Genet. 2011
PubMed ID: 21828077
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Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Ross OA, Soto-Ortolaza AI, Heckman MG, Aasly JO, Abahuni N, Annesi G, Bacon JA, Bardien S, Bozi M, Brice A, Brighina L, Van Broeckhoven C, Carr J, Chartier-Harlin MC, Dardiotis E, Dickson DW, Diehl NN, Elbaz A, Ferrarese C, Ferraris A, Fiske B, Gibson JM, Gibson R, Hadjigeorgiou GM, Hattori N, Ioannidis JP, Jasinska-Myga B, Jeon BS, Kim YJ, Klein C, Kruger R, Kyratzi E, Lesage S, Lin CH, Lynch T, Maraganore DM, Mellick GD, Mutez E, Nilsson C, Opala G, Park SS, Puschmann A, Quattrone A, Sharma M, Silburn PA, Sohn YH, Stefanis L, Tadic V, Theuns J, Tomiyama H, Uitti RJ, Valente EM, van de Loo S, Vassilatis DK, Vilariño-Güell C, White LR, Wirdefeldt K, Wszolek ZK, Wu RM, Farrer MJ, Genetic Epidemiology Of Parkinson's Disease (GEO-PD) Consortium
Lancet Neurol. 2011
PubMed ID: 21885347
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Frequencies of LRRK2 variants in Thai patients with Parkinson's disease: evidence for an R1628P founder.
Pulkes T, Papsing C, Mahasirimongkol S, Busabaratana M, Kulkantrakorn K, Tiamkao S
J Neurol Neurosurg Psychiatry. 2011
PubMed ID: 20571044
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Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.
Mutez E, Larvor L, Leprêtre F, Mouroux V, Hamalek D, Kerckaert JP, Pérez-Tur J, Waucquier N, Vanbesien-Mailliot C, Duflot A, Devos D, Defebvre L, Kreisler A, Frigard B, Destée A, Chartier-Harlin MC
Neurobiol Aging. 2011
PubMed ID: 20096956
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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities.
Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB
J Mol Biol. 2011
PubMed ID: 21806997
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Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease.
Seki N, Takahashi Y, Tomiyama H, Rogaeva E, Murayama S, Mizuno Y, Hattori N, Marras C, Lang AE, George-Hyslop PS, Goto J, Tsuji S
J Hum Genet. 2011
PubMed ID: 21796139
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Kin-cohort analysis of LRRK2-G2019S penetrance in Parkinson's disease.
Goldwurm S, Tunesi S, Tesei S, Zini M, Sironi F, Primignani P, Magnani C, Pezzoli G
Mov Disord. 2011
PubMed ID: 21714003
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Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease.
Latourelle JC, Hendricks AE, Pankratz N, Wilk JB, Halter C, Nichols WC, Gusella JF, Destefano AL, Myers RH, Foroud T, PSG-Progeni GenePD Investigators, Coordinators, and Molecular Genetic Laboratories
Mov Disord. 2011
PubMed ID: 21661047
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Olfactory deficits and cardiac 123I-MIBG in Parkinson's disease related to the LRRK2 R1441G and G2019S mutations.
Ruiz-Martínez J, Gorostidi A, Goyenechea E, Alzualde A, Poza JJ, Rodríguez F, Bergareche A, Moreno F, López de Munain A, Martí Massó JF
Mov Disord. 2011
PubMed ID: 21611983
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Subclinical signs in LRRK2 mutation carriers.
Johansen KK, White LR, Farrer MJ, Aasly JO
Parkinsonism Relat Disord. 2011
PubMed ID: 21641848
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Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease.
Bardien S, Lesage S, Brice A, Carr J
Parkinsonism Relat Disord. 2011
PubMed ID: 21641266
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The LRRK2 R1441C mutation is more frequent than G2019S in Parkinson's disease patients from southern Italy.
Criscuolo C, De Rosa A, Guacci A, Simons EJ, Breedveld GJ, Peluso S, Volpe G, Filla A, Oostra BA, Bonifati V, De Michele G
Mov Disord. 2011
PubMed ID: 21538529
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LRRK2 G2019S mutations may be increased in Puerto Ricans.
Saunders-Pullman R, Cabassa J, San Luciano M, Stanley K, Raymond D, Ozelius LJ, Bressman SB
Mov Disord. 2011
PubMed ID: 21449009
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A study of six point mutation analysis of LRRK2 gene in Chinese mainland patients with Parkinson's disease.
Hu ZX, Peng DT, Cai M, Pu JL, Lei XG, Yin XZ, Ou-Yang ZY, Luo W, Zhang BR
Neurol Sci. 2011
PubMed ID: 21234781
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Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers.
Marras C, Schuele B, Munhoz RP, Rogaeva E, Langston JW, Kasten M, Meaney C, Klein C, Wadia PM, Lim SY, Chuang RS, Zadikof C, Steeves T, Prakash KM, de Bie RM, Adeli G, Thomsen T, Johansen KK, Teive HA, Asante A, Reginold W, Lang AE
Neurology. 2011
PubMed ID: 21753163
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Olfactory dysfunction in LRRK2 G2019S mutation carriers.
Saunders-Pullman R, Stanley K, Wang C, San Luciano M, Shanker V, Hunt A, Severt L, Raymond D, Ozelius LJ, Lipton RB, Bressman SB
Neurology. 2011
PubMed ID: 21753159
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LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
Ohta E, Kawakami F, Kubo M, Obata F
FEBS Lett. 2011
PubMed ID: 21658387
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Differential gene expression in patients with amyotrophic lateral sclerosis.
Shtilbans A, Choi SG, Fowkes ME, Khitrov G, Shahbazi M, Ting J, Zhang W, Sun Y, Sealfon SC, Lange DJ
Amyotroph Lateral Scler. 2011
PubMed ID: 21375368
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
Do CB, Tung JY, Dorfman E, Kiefer AK, Drabant EM, Francke U, Mountain JL, Goldman SM, Tanner CM, Langston JW, Wojcicki A, Eriksson N
PLoS Genet. 2011
PubMed ID: 21738487
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The lrrk2 p.Gly2019Ser mutation is uncommon in a Danish cohort with various neurodegenerative disorders.
Bech S, Nørremølle A, Winge K, Hasholt L, Tommerup N, Svenstrup K, Nielsen JE, Hjermind LE
Parkinsonism Relat Disord. 2011
PubMed ID: 21353620
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123I-MIBG cardiac uptake and smell identification in parkinsonian patients with LRRK2 mutations.
Valldeoriola F, Gaig C, Muxí A, Navales I, Paredes P, Lomeña F, De la Cerda A, Buongiorno M, Ezquerra M, Santacruz P, Martí MJ, Tolosa E
J Neurol. 2011
PubMed ID: 21221623
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LRRK2 Pro755Leu variant in ethnic Chinese population with Parkinson's disease.
Yao LY, Guo JF, Wang L, Yu RH, Sun QY, Pan Q, Xia K, Tang BS, Shen L
Neurosci Lett. 2011
PubMed ID: 21406209
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Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2).
Chan D, Citro A, Cordy JM, Shen GC, Wolozin B
J Biol Chem. 2011
PubMed ID: 21454543
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Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG
J Neural Transm. 2011
PubMed ID: 21552986
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LRRK2 R1398H polymorphism is associated with decreased risk of Parkinson's disease in a Han Chinese population.
Chen L, Zhang S, Liu Y, Hong H, Wang H, Zheng Y, Zhou H, Chen J, Xian W, He Y, Li J, Liu Z, Pei Z, Zeng J
Parkinsonism Relat Disord. 2011
PubMed ID: 21159540
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Substantia nigra hyperechogenicity with LRRK2 G2019S mutations.
Brüggemann N, Hagenah J, Stanley K, Klein C, Wang C, Raymond D, Ozelius L, Bressman S, Saunders-Pullman R
Mov Disord. 2011
PubMed ID: 21312285
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LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.
Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schüle B, Dolmetsch RE, Langston W, Palmer TD, Pera RR
Cell Stem Cell. 2011
PubMed ID: 21362567
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LRRK2 G2019S mutation does not contribute to Parkinson's disease in South India.
Vijayan B, Gopala S, Kishore A
Neurol India. 2011
PubMed ID: 21483109
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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice.
Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, Braithwaite AT, Ogholikhan S, Aigner R, Winkler J, Farrer MJ, Gage FH
Neurobiol Dis. 2011
PubMed ID: 21168496
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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
International Parkinson Disease Genomics Consortium, Nalls MA, Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón-Sánchez J, Schulte C, Lesage S, Sveinbjörnsdóttir S, Stefánsson K, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW
Lancet. 2011
PubMed ID: 21292315
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LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C, Ueffing M
J Neurosci. 2011
PubMed ID: 21307259
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Lrrk2 S1647T and BDNF V66M interact with environmental factors to increase risk of Parkinson's disease.
Lin CH, Wu RM, Tai CH, Chen ML, Hu FC
Parkinsonism Relat Disord. 2011
PubMed ID: 21167764
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Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, Davies H, Jones D, Lin ML, Teague J, Bignell G, Butler A, Cho J, Dalgliesh GL, Galappaththige D, Greenman C, Hardy C, Jia M, Latimer C, Lau KW, Marshall J, McLaren S, Menzies A, Mudie L, Stebbings L, Largaespada DA, Wessels LF, Richard S, Kahnoski RJ, Anema J, Tuveson DA, Perez-Mancera PA, Mustonen V, Fischer A, Adams DJ, Rust A, Chan-on W, Subimerb C, Dykema K, Furge K, Campbell PJ, Teh BT, Stratton MR, Futreal PA
Nature. 2011
PubMed ID: 21248752
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Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas.
Looyenga BD, Furge KA, Dykema KJ, Koeman J, Swiatek PJ, Giordano TJ, West AB, Resau JH, Teh BT, MacKeigan JP
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21220347
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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.
Taymans JM, Vancraenenbroeck R, Ollikainen P, Beilina A, Lobbestael E, De Maeyer M, Baekelandt V, Cookson MR
PLoS One. 2011
PubMed ID: 21858031
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Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans.
Yuan Y, Cao P, Smith MA, Kramp K, Huang Y, Hisamoto N, Matsumoto K, Hatzoglou M, Jin H, Feng Z
PLoS One. 2011
PubMed ID: 21857923
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Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue.
Devine MJ, Kaganovich A, Ryten M, Mamais A, Trabzuni D, Manzoni C, McGoldrick P, Chan D, Dillman A, Zerle J, Horan S, Taanman JW, Hardy J, Marti-Masso JF, Healy D, Healey D, Schapira AH, Wolozin B, Bandopadhyay R, Cookson MR, van der Brug MP, Lewis PA
PLoS One. 2011
PubMed ID: 21799870
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Regulation of LRRK2 expression points to a functional role in human monocyte maturation.
Thévenet J, Pescini Gobert R, Hooft van Huijsduijnen R, Wiessner C, Sagot YJ
PLoS One. 2011
PubMed ID: 21738687
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α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells.
Kondo K, Obitsu S, Teshima R
Biol Pharm Bull. 2011
PubMed ID: 21720016
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Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.
Zhou H, Huang C, Tong J, Hong WC, Liu YJ, Xia XG
Int J Biol Sci. 2011
PubMed ID: 21698001
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Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells.
Schulz C, Paus M, Frey K, Schmid R, Kohl Z, Mennerich D, Winkler J, Gillardon F
PLoS One. 2011
PubMed ID: 21695257
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LRRK2 Parkinson's disease: from animal models to cellular mechanisms.
Lin CH, Tsai PI, Wu RM, Chien CT
Rev Neurosci. 2011
PubMed ID: 21679126
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Role of LRRK2 kinase dysfunction in Parkinson disease.
Kumar A, Cookson MR
Expert Rev Mol Med. 2011
PubMed ID: 21676337
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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.
Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, Jenkins NA, Copeland NG, Galter D, Thomas B, Lee MK, Dawson TM, Dawson VL, Moore DJ
PLoS One. 2011
PubMed ID: 21494637
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Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z
PLoS One. 2011
PubMed ID: 21390248
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Gait alterations in healthy carriers of the LRRK2 G2019S mutation.
Mirelman A, Gurevich T, Giladi N, Bar-Shira A, Orr-Urtreger A, Hausdorff JM
Ann Neurol. 2011
PubMed ID: 21280089
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Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant.
Daniëls V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, Taymans JM
J Neurochem. 2011
PubMed ID: 21073465
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A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.
Meixner A, Boldt K, Van Troys M, Askenazi M, Gloeckner CJ, Bauer M, Marto JA, Ampe C, Kinkl N, Ueffing M
Mol Cell Proteomics. 2011
PubMed ID: 20876399
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Dopamine turnover increases in asymptomatic LRRK2 mutations carriers.
Sossi V, de la Fuente-Fernández R, Nandhagopal R, Schulzer M, McKenzie J, Ruth TJ, Aasly JO, Farrer MJ, Wszolek ZK, Stoessl JA
Mov Disord. 2010
PubMed ID: 20939082
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LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.
Kubo M, Kamiya Y, Nagashima R, Maekawa T, Eshima K, Azuma S, Ohta E, Obata F
J Neuroimmunol. 2010
PubMed ID: 20728949
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M
Nat Genet. 2010
PubMed ID: 21102463
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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease.
Cookson MR
Nat Rev Neurosci. 2010
PubMed ID: 21088684
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LRRK2 G2019S mutation in Parkinson's disease: A neuropsychological and neuropsychiatric study in a large Algerian cohort.
Belarbi S, Hecham N, Lesage S, Kediha MI, Smail N, Benhassine T, Ysmail-Dahlouk F, Lohman E, Benhabyles B, Hamadouche T, Assami S, Brice A, Tazir M
Parkinsonism Relat Disord. 2010
PubMed ID: 20933457
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A comparative study of Lrrk2 function in primary neuronal cultures.
Dächsel JC, Behrouz B, Yue M, Beevers JE, Melrose HL, Farrer MJ
Parkinsonism Relat Disord. 2010
PubMed ID: 20850369
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Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.
Melrose HL, Dächsel JC, Behrouz B, Lincoln SJ, Yue M, Hinkle KM, Kent CB, Korvatska E, Taylor JP, Witten L, Liang YQ, Beevers JE, Boules M, Dugger BN, Serna VA, Gaukhman A, Yu X, Castanedes-Casey M, Braithwaite AT, Ogholikhan S, Yu N, Bass D, Tyndall G, Schellenberg GD, Dickson DW, Janus C, Farrer MJ
Neurobiol Dis. 2010
PubMed ID: 20659558
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Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.
Mortiboys H, Johansen KK, Aasly JO, Bandmann O
Neurology. 2010
PubMed ID: 21115957
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Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease.
Yescas P, López M, Monroy N, Boll MC, Rodríguez-Violante M, Rodríguez U, Ochoa A, Alonso ME
Neurosci Lett. 2010
PubMed ID: 20727385
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LRRK2 G2019S mutations are associated with an increased cancer risk in Parkinson disease.
Saunders-Pullman R, Barrett MJ, Stanley KM, Luciano MS, Shanker V, Severt L, Hunt A, Raymond D, Ozelius LJ, Bressman SB
Mov Disord. 2010
PubMed ID: 20818610
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Clinical expression of LRRK2 G2019S mutations in the elderly.
San Luciano M, Lipton RB, Wang C, Katz M, Zimmerman ME, Sanders AE, Ozelius LJ, Bressman SB, Saunders-Pullman R
Mov Disord. 2010
PubMed ID: 20721910
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LRRK2 is involved in the IFN-gamma response and host response to pathogens.
Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, Podolsky DK
J Immunol. 2010
PubMed ID: 20921534
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Penetrance in Parkinson's disease related to the LRRK2 R1441G mutation in the Basque country (Spain).
Ruiz-Martínez J, Gorostidi A, Ibañez B, Alzualde A, Otaegui D, Moreno F, López de Munain A, Bergareche A, Gómez-Esteban JC, Massó JF
Mov Disord. 2010
PubMed ID: 20721916
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Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.
Jasinska-Myga B, Kachergus J, Vilariño-Güell C, Wider C, Soto-Ortolaza AI, Kefi M, Middleton LT, Ishihara-Paul L, Gibson RA, Amouri R, Yahmed SB, Sassi SB, Zouari M, El Euch G, Ross OA, Hentati F, Farrer MJ
Mov Disord. 2010
PubMed ID: 20721913
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LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan.
Miyake Y, Tsuboi Y, Koyanagi M, Fujimoto T, Shirasawa S, Kiyohara C, Tanaka K, Fukushima W, Sasaki S, Yamada T, Oeda T, Miki T, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Fukuoka Kinki Parkinson's Disease Study Group
J Neurol Sci. 2010
PubMed ID: 20673920
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Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease.
Aasly JO, Vilariño-Güell C, Dachsel JC, Webber PJ, West AB, Haugarvoll K, Johansen KK, Toft M, Nutt JG, Payami H, Kachergus JM, Lincoln SJ, Felic A, Wider C, Soto-Ortolaza AI, Cobb SA, White LR, Ross OA, Farrer MJ
Mov Disord. 2010
PubMed ID: 20669305
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Absence of commonly reported leucine-rich repeat kinase 2 mutations in eastern Indian Parkinson's disease patients.
Sanyal J, Sarkar B, Ojha S, Banerjee TK, Ray BC, Rao VR
Genet Test Mol Biomarkers. 2010
PubMed ID: 20722494
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The G2019S pathogenic mutation disrupts sensitivity of leucine-rich repeat kinase 2 to manganese kinase inhibition.
Covy JP, Giasson BI
J Neurochem. 2010
PubMed ID: 20626563
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LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease.
Yao C, El Khoury R, Wang W, Byrd TA, Pehek EA, Thacker C, Zhu X, Smith MA, Wilson-Delfosse AL, Chen SG
Neurobiol Dis. 2010
PubMed ID: 20382224
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LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.
Lin CH, Tsai PI, Wu RM, Chien CT
J Neurosci. 2010
PubMed ID: 20881132
-
Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2.
Li X, Moore DJ, Xiong Y, Dawson TM, Dawson VL
J Biol Chem. 2010
PubMed ID: 20595391
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LRRK2 variation and Parkinson's disease in African Americans.
Ross OA, Wilhoite GJ, Bacon JA, Soto-Ortolaza A, Kachergus J, Cobb SA, Puschmann A, Vilariño-Güell C, Farrer MJ, Graff-Radford N, Meschia JF, Wszolek ZK
Mov Disord. 2010
PubMed ID: 20669299
-
Olfactory heterogeneity in LRRK2 related Parkinsonism.
Silveira-Moriyama L, Munhoz RP, de J Carvalho M, Raskin S, Rogaeva E, de C Aguiar P, Bressan RA, Felicio AC, Barsottini OG, Andrade LA, Chien HF, Bonifati V, Barbosa ER, Teive HA, Lees AJ
Mov Disord. 2010
PubMed ID: 20818658
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Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.
Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM
Nat Med. 2010
PubMed ID: 20729864
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Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease.
Vitte J, Traver S, Maués De Paula A, Lesage S, Rovelli G, Corti O, Duyckaerts C, Brice A
J Neuropathol Exp Neurol. 2010
PubMed ID: 20720502
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Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, Kay DM, Doheny KF, Paschall J, Pugh E, Kusel VI, Collura R, Roberts J, Griffith A, Samii A, Scott WK, Nutt J, Factor SA, Payami H
Nat Genet. 2010
PubMed ID: 20711177
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Structural imaging in the presymptomatic stage of genetically determined parkinsonism.
Reetz K, Tadic V, Kasten M, Brüggemann N, Schmidt A, Hagenah J, Pramstaller PP, Ramirez A, Behrens MI, Siebner HR, Klein C, Binkofski F
Neurobiol Dis. 2010
PubMed ID: 20483373
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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.
Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR
Biochem J. 2010
PubMed ID: 20642453
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Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.
Tan EK, Kwok HH, Kwok HK, Tan LC, Zhao WT, Prakash KM, Au WL, Pavanni R, Ng YY, Satake W, Zhao Y, Toda T, Liu JJ
Neurology. 2010
PubMed ID: 20697102
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Expression of leucine-rich-repeat-kinase 2 (LRRK2) during embryonic development.
Zechel S, Meinhardt A, Unsicker K, von Bohlen Und Halbach O
Int J Dev Neurosci. 2010
PubMed ID: 20403420
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Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.
Gomez A, Ferrer I
Acta Neuropathol. 2010
PubMed ID: 20232069
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Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.
Gehrke S, Imai Y, Sokol N, Lu B
Nature. 2010
PubMed ID: 20671708
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Confirmation of LRRK2 S1647T variant as a risk factor for Parkinson's disease in Southern China.
Zheng Y, Liu Y, Wu Q, Hong H, Zhou H, Chen J, Wang H, Xian W, Li J, Liu Z, Pei Z, Chen L
Eur J Neurol. 2010
PubMed ID: 20629711
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Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation.
Berger Z, Smith KA, Lavoie MJ
Biochemistry. 2010
PubMed ID: 20515039
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LRRK2 G2019S mutation: frequency and haplotype data in South African Parkinson's disease patients.
Bardien S, Marsberg A, Keyser R, Lombard D, Lesage S, Brice A, Carr J
J Neural Transm. 2010
PubMed ID: 20544233
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Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.
Nuytemans K, Theuns J, Cruts M, Van Broeckhoven C
Hum Mutat. 2010
PubMed ID: 20506312
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S
Inflamm Bowel Dis. 2010
PubMed ID: 19760754
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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.
Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20457918
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[Genetic screening for the LRRK2, G2019S and R1441 codon mutations in Parkinson's disease patients from Extremadura, Spain]
Morán JM, Castellanos-Pinedo F, Casado-Naranjo I, Durán-Herrera C, Ramírez-Moreno JM, Gómez M, Zurdo-Hernández JM, Fuentes E, Ortiz-Ortiz MA, Moreno AD, González-Polo RA, Niso-Santano M, Bravo-Sanpedro JM, Pérez-Tur J, Ruiz-Mesa LM, Fuentes JM
Rev Neurol. 2010
PubMed ID: 20473834
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Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans.
Lesage S, Patin E, Condroyer C, Leutenegger AL, Lohmann E, Giladi N, Bar-Shira A, Belarbi S, Hecham N, Pollak P, Ouvrard-Hernandez AM, Bardien S, Carr J, Benhassine T, Tomiyama H, Pirkevi C, Hamadouche T, Cazeneuve C, Basak AN, Hattori N, Dürr A, Tazir M, Orr-Urtreger A, Quintana-Murci L, Brice A, French Parkinson's Disease Genetics Study Group
Hum Mol Genet. 2010
PubMed ID: 20197411
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Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.
Tan EK, Peng R, Teo YY, Tan LC, Angeles D, Ho P, Chen ML, Lin CH, Mao XY, Chang XL, Prakash KM, Liu JJ, Au WL, Le WD, Jankovic J, Burgunder JM, Zhao Y, Wu RM
Hum Mutat. 2010
PubMed ID: 20186690
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Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.
Carballo-Carbajal I, Weber-Endress S, Rovelli G, Chan D, Wolozin B, Klein CL, Patenge N, Gasser T, Kahle PJ
Cell Signal. 2010
PubMed ID: 20074637
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Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.
Correia Guedes L, Ferreira JJ, Rosa MM, Coelho M, Bonifati V, Sampaio C
Parkinsonism Relat Disord. 2010
PubMed ID: 19945904
-
Genetic analysis of LRRK2 functional domains in Brazilian patients with Parkinson's disease.
Abdalla-Carvalho CB, Santos-Rebouças CB, Guimarães BC, Campos M, Pereira JS, Zuma de Rosso AL, Nicaretta DH, Marinho E Silva M, Mendonça Dos Santos J, Pimentel MM
Eur J Neurol. 2010
PubMed ID: 20443975
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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.
Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, Ueffing M
J Proteome Res. 2010
PubMed ID: 20108944
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Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease.
Phillips AM, Nimmo ER, Van Limbergen J, Drummond HE, Smith L, Satsangi J
Inflamm Bowel Dis. 2010
PubMed ID: 19714762
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LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation.
Marras C, Klein C, Lang AE, Wakutani Y, Moreno D, Sato C, Yip E, Munhoz RP, Lohmann K, Djarmati A, Bi A, Rogaeva E
Neurobiol Aging. 2010
PubMed ID: 18644660
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Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities.
Liu M, Dobson B, Glicksman MA, Yue Z, Stein RL
Biochemistry. 2010
PubMed ID: 20146535
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MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
Hsu CH, Chan D, Greggio E, Saha S, Guillily MD, Ferree A, Raghavan K, Shen GC, Segal L, Ryu H, Cookson MR, Wolozin B
J Neurochem. 2010
PubMed ID: 20067578
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Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease.
Alcalay RN, Mejia-Santana H, Tang MX, Rakitin B, Rosado L, Ross B, Verbitsky M, Kisselev S, Louis ED, Comella CL, Colcher A, Jennings D, Nance MA, Bressman S, Scott WK, Tanner C, Mickel SF, Andrews HF, Waters CH, Fahn S, Cote LJ, Frucht SJ, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Ottman R, Clark LN, Marder KS, Caccappolo E
J Clin Exp Neuropsychol. 2010
PubMed ID: 20182943
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LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.
Heo HY, Park JM, Kim CH, Han BS, Kim KS, Seol W
Exp Cell Res. 2010
PubMed ID: 19769964
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Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.
Maekawa T, Kubo M, Yokoyama I, Ohta E, Obata F
Biochem Biophys Res Commun. 2010
PubMed ID: 20079710
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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S.
Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z
J Neurosci. 2010
PubMed ID: 20130188
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The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population.
Kim JM, Lee JY, Kim HJ, Kim JS, Shin ES, Cho JH, Park SS, Jeon BS
Parkinsonism Relat Disord. 2010
PubMed ID: 19854095
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LRRK2 and GBA mutations differentially affect the initial presentation of Parkinson disease.
Gan-Or Z, Bar-Shira A, Mirelman A, Gurevich T, Kedmi M, Giladi N, Orr-Urtreger A
Neurogenetics. 2010
PubMed ID: 19458969
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Association between GBA L444P mutation and sporadic Parkinson's disease from Mainland China.
Mao XY, Burgunder JM, Zhang ZJ, An XK, Zhang JH, Yang Y, Li T, Wang YC, Chang XL, Peng R
Neurosci Lett. 2010
PubMed ID: 20004703
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A novel LRRK2 mutation in a mainland Chinese patient with familial Parkinson's disease.
Wang L, Guo JF, Nie LL, Xu Q, Zuo X, Sun QY, Yan XX, Tang BS
Neurosci Lett. 2010
PubMed ID: 19879329
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Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells.
Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Niso-Santano M, Bravo-SanPedro JM, Gómez-Sánchez R, González-Polo RA, Fuentes JM
Neurosci Lett. 2010
PubMed ID: 19879924
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Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
Laukens D, Georges M, Libioulle C, Sandor C, Mni M, Vander Cruyssen B, Peeters H, Elewaut D, De Vos M
PLoS One. 2010
PubMed ID: 21072187
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Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif.
Pungaliya PP, Bai Y, Lipinski K, Anand VS, Sen S, Brown EL, Bates B, Reinhart PH, West AB, Hirst WD, Braithwaite SP
PLoS One. 2010
PubMed ID: 21060682
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ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2.
Haebig K, Gloeckner CJ, Miralles MG, Gillardon F, Schulte C, Riess O, Ueffing M, Biskup S, Bonin M
PLoS One. 2010
PubMed ID: 21048939
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Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.
Zach S, Felk S, Gillardon F
PLoS One. 2010
PubMed ID: 20949042
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LRRK2 G2019S in the North African population: a review.
Benamer HT, de Silva R
Eur Neurol. 2010
PubMed ID: 20413974
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GTPase activity plays a key role in the pathobiology of LRRK2.
Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ
PLoS Genet. 2010
PubMed ID: 20386743
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Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation.
Wider C, Dickson DW, Wszolek ZK
Neurodegener Dis. 2010
PubMed ID: 20197701
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The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.
Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR
PLoS One. 2010
PubMed ID: 20090955
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Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis.
Ohta E, Kubo M, Obata F
Biochem Biophys Res Commun. 2010
PubMed ID: 19912990
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Genomewide association study of leprosy.
Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Yang RD, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ
N Engl J Med. 2009
PubMed ID: 20018961
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Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease.
Qing H, Zhang Y, Deng Y, McGeer EG, McGeer PL
Biochem Biophys Res Commun. 2009
PubMed ID: 19878656
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Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization.
Sen S, Webber PJ, West AB
J Biol Chem. 2009
PubMed ID: 19826009
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Identification of four novel potentially Parkinson's disease associated LRRK2 variations among Iranian patients.
Shojaee S, Fazlali Z, Ghazavi F, Banihosseini SS, Kazemi MH, Parsa K, Sadeghi H, Sina F, Shahidi GA, Ronaghi M, Elahi E
Neurosci Lett. 2009
PubMed ID: 19800393
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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.
Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, Liu Z, Li Z, Cai H
Neuron. 2009
PubMed ID: 20064389
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I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule.
Ohta E, Katayama Y, Kawakami F, Yamamoto M, Tajima K, Maekawa T, Iida N, Hattori S, Obata F
Biochem Biophys Res Commun. 2009
PubMed ID: 19833102
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Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).
Andres-Mateos E, Mejias R, Sasaki M, Li X, Lin BM, Biskup S, Zhang L, Banerjee R, Thomas B, Yang L, Liu G, Beal MF, Huso DL, Dawson TM, Dawson VL
J Neurosci. 2009
PubMed ID: 20016100
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LRRK2 variant associated with Alzheimer's disease.
Zhao Y, Ho P, Yih Y, Chen C, Lee WL, Tan EK
Neurobiol Aging. 2009
PubMed ID: 20018409
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Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease.
Alcalay RN, Mejia-Santana H, Tang MX, Rosado L, Verbitsky M, Kisselev S, Ross BM, Louis ED, Comella CL, Colcher A, Jennings D, Nance MA, Bressman S, Scott WK, Tanner C, Mickel SF, Andrews HF, Waters CH, Fahn S, Cote LJ, Frucht SJ, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Caccappolo E, Ottman R, Clark LN, Marder KS
Arch Neurol. 2009
PubMed ID: 20008657
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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
Nat Genet. 2009
PubMed ID: 19915576
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Genome-wide association study reveals genetic risk underlying Parkinson's disease.
Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illig T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, Gwinn K, van der Brug M, Lopez G, Chanock SJ, Schatzkin A, Park Y, Hollenbeck A, Gao J, Huang X, Wood NW, Lorenz D, Deuschl G, Chen H, Riess O, Hardy JA, Singleton AB, Gasser T
Nat Genet. 2009
PubMed ID: 19915575
-
Identification of the autophosphorylation sites of LRRK2.
Kamikawaji S, Ito G, Iwatsubo T
Biochemistry. 2009
PubMed ID: 19824698
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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites.
Greggio E, Taymans JM, Zhen EY, Ryder J, Vancraenenbroeck R, Beilina A, Sun P, Deng J, Jaffe H, Baekelandt V, Merchant K, Cookson MR
Biochem Biophys Res Commun. 2009
PubMed ID: 19733152
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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.
Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR
Biochem J. 2009
PubMed ID: 19740074
-
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS
Hum Mol Genet. 2009
PubMed ID: 19692353
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Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.
Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, Cai H
J Neurosci. 2009
PubMed ID: 19890007
-
LRRK2 R1628P contributes to Parkinson's disease susceptibility in Chinese Han populations from mainland China.
Yu L, Hu F, Zou X, Jiang Y, Liu Y, He X, Xi J, Liu L, Liu Z, He L, Xu Y
Brain Res. 2009
PubMed ID: 19699188
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LRRK2 in Parkinson's disease: genetic and clinical studies from patients.
Kumari U, Tan EK
FEBS J. 2009
PubMed ID: 19804413
-
Parkinson disease, LRRK2 and the endocytic-autophagic pathway.
Alegre-Abarrategui J, Wade-Martins R
Autophagy. 2009
PubMed ID: 19770575
-
The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews.
Thaler A, Ash E, Gan-Or Z, Orr-Urtreger A, Giladi N
J Neural Transm. 2009
PubMed ID: 19756366
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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model.
Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, Ansorge O, Wade-Martins R
Hum Mol Genet. 2009
PubMed ID: 19640926
-
Screening for LRRK2 R1441 mutations in a cohort of PSP patients from Germany.
Madzar D, Schulte C, Gasser T
Eur J Neurol. 2009
PubMed ID: 19538213
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Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2.
Martí-Massó JF, Ruiz-Martínez J, Bolaño MJ, Ruiz I, Gorostidi A, Moreno F, Ferrer I, de Munain AL
Mov Disord. 2009
PubMed ID: 19735093
-
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.
Sancho RM, Law BM, Harvey K
Hum Mol Genet. 2009
PubMed ID: 19625296
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Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro.
Gillardon F
Neuroscience. 2009
PubMed ID: 19559761
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Lrrk2 R1441G-related Parkinson's disease: evidence of a common founding event in the seventh century in Northern Spain.
Mata IF, Hutter CM, González-Fernández MC, de Pancorbo MM, Lezcano E, Huerta C, Blazquez M, Ribacoba R, Guisasola LM, Salvador C, Gómez-Esteban JC, Zarranz JJ, Infante J, Jankovic J, Deng H, Edwards KL, Alvarez V, Zabetian CP
Neurogenetics. 2009
PubMed ID: 19308469
-
Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries.
Bar-Shira A, Hutter CM, Giladi N, Zabetian CP, Orr-Urtreger A
Neurogenetics. 2009
PubMed ID: 19283415
-
Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications.
Qing H, Wong W, McGeer EG, McGeer PL
Biochem Biophys Res Commun. 2009
PubMed ID: 19576176
-
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL
J Neurosci. 2009
PubMed ID: 19741132
-
A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson disease.
Nishioka K, Kefi M, Jasinska-Myga B, Wider C, Vilarino-Guell C, Ross OA, Heckman MG, Middleton LT, Ishihara-Paul L, Gibson RA, Amouri R, Yahmed SB, Sassi SB, Zouari M, Euch GE, Farrer MJ, Hentati F
J Neurol Neurosurg Psychiatry. 2009
PubMed ID: 19726410
-
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease.
Higashi S, Moore DJ, Yamamoto R, Minegishi M, Sato K, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Emson PC, Wada K, Dawson VL, Dawson TM, Arai H, Iseki E
J Neuropathol Exp Neurol. 2009
PubMed ID: 19680143
-
Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?
Gillardon F
J Neurochem. 2009
PubMed ID: 19545277
-
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.
Tong Y, Pisani A, Martella G, Karouani M, Yamaguchi H, Pothos EN, Shen J
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19667187
-
LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
Zhang Z, Burgunder JM, An X, Wu Y, Chen W, Zhang J, Wang Y, Xu Y, Gou Y, Yuan G, Mao X, Peng R
Mov Disord. 2009
PubMed ID: 19672984
-
Prevalence and clinical features of LRRK2 mutations in patients with Parkinson's disease in southern Spain.
Gao L, Gómez-Garre P, Díaz-Corrales FJ, Carrillo F, Carballo M, Palomino A, Díaz-Martín J, Mejías R, Vime PJ, López-Barneo J, Mir P
Eur J Neurol. 2009
PubMed ID: 19473361
-
LRRK2 gene variation and its contribution to Parkinson disease.
Paisán-Ruiz C
Hum Mutat. 2009
PubMed ID: 19472409
-
Genetic factors influencing age at onset in LRRK2-linked Parkinson disease.
Golub Y, Berg D, Calne DB, Pfeiffer RF, Uitti RJ, Stoessl AJ, Wszolek ZK, Farrer MJ, Mueller JC, Gasser T, Fuchs J
Parkinsonism Relat Disord. 2009
PubMed ID: 19041274
-
Analysis of the LRRK2 Gly2385Arg variant in Alzheimer's disease in Taiwan.
Chang TY, Kuo HC, Lu CS, Wu-Chou YH, Huang CC
Parkinsonism Relat Disord. 2009
PubMed ID: 19640773
-
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L, Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein L, Cookson M, Wolozin B
J Neurosci. 2009
PubMed ID: 19625511
-
Leucine-rich repeat kinase 2 expression leads to aggresome formation that is not associated with alpha-synuclein inclusions.
Waxman EA, Covy JP, Bukh I, Li X, Dawson TM, Giasson BI
J Neuropathol Exp Neurol. 2009
PubMed ID: 19535993
-
Parkinson's disease and low frequency alleles found together throughout LRRK2.
Paisán-Ruiz C, Washecka N, Nath P, Singleton AB, Corder EH
Ann Hum Genet. 2009
PubMed ID: 19489756
-
Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population.
Nuytemans K, Meeus B, Crosiers D, Brouwers N, Goossens D, Engelborghs S, Pals P, Pickut B, Van den Broeck M, Corsmit E, Cras P, De Deyn PP, Del-Favero J, Van Broeckhoven C, Theuns J
Hum Mutat. 2009
PubMed ID: 19405094
-
Molecular analyses of the LRRK2 gene in European and North African autosomal dominant Parkinson's disease.
Lesage S, Condroyer C, Lannuzel A, Lohmann E, Troiano A, Tison F, Damier P, Thobois S, Ouvrard-Hernandez AM, Rivaud-Péchoux S, Brefel-Courbon C, Destée A, Tranchant C, Romana M, Leclere L, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group
J Med Genet. 2009
PubMed ID: 19357115
-
A LRRK2 G2019S mutation carrier from Turkey shares the Japanese haplotype.
Pirkevi C, Lesage S, Condroyer C, Tomiyama H, Hattori N, Ertan S, Brice A, Başak AN
Neurogenetics. 2009
PubMed ID: 19172321
-
Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.
Biskup S, West AB
Biochim Biophys Acta. 2009
PubMed ID: 18973807
-
Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.
Ross OA, Spanaki C, Griffith A, Lin CH, Kachergus J, Haugarvoll K, Latsoudis H, Plaitakis A, Ferreira JJ, Sampaio C, Bonifati V, Wu RM, Zabetian CP, Farrer MJ
Parkinsonism Relat Disord. 2009
PubMed ID: 18952485
-
Leucine-rich repeat kinase 2 mutants I2020T and G2019S exhibit altered kinase inhibitor sensitivity.
Reichling LJ, Riddle SM
Biochem Biophys Res Commun. 2009
PubMed ID: 19397894
-
Mutations in the Parkinson's disease genes, Leucine Rich Repeat Kinase 2 (LRRK2) and Glucocerebrosidase (GBA), are not associated with essential tremor.
Clark LN, Kisselev S, Park N, Ross B, Verbitsky M, Rios E, Alcalay RN, Lee JH, Louis ED
Parkinsonism Relat Disord. 2009
PubMed ID: 19527940
-
A clinic-based screening of mutations in exons 31, 34, 35, 41, and 48 of LRRK2 in Iranian Parkinson's disease patients.
Shojaee S, Sina F, Farboodi N, Fazlali Z, Ghazavi F, Ghorashi SA, Parsa K, Sadeghi H, Shahidi GA, Ronaghi M, Elahi E
Mov Disord. 2009
PubMed ID: 19353692
-
LRRK2 mutations and risk variants in Japanese patients with Parkinson's disease.
Zabetian CP, Yamamoto M, Lopez AN, Ujike H, Mata IF, Izumi Y, Kaji R, Maruyama H, Morino H, Oda M, Hutter CM, Edwards KL, Schellenberg GD, Tsuang DW, Yearout D, Larson EB, Kawakami H
Mov Disord. 2009
PubMed ID: 19343804
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro.
Gloeckner CJ, Schumacher A, Boldt K, Ueffing M
J Neurochem. 2009
PubMed ID: 19302196
-
Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease.
Gandhi PN, Chen SG, Wilson-Delfosse AL
J Neurosci Res. 2009
PubMed ID: 19025767
-
Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.
Hasegawa K, Stoessl AJ, Yokoyama T, Kowa H, Wszolek ZK, Yagishita S
Parkinsonism Relat Disord. 2009
PubMed ID: 18804399
-
A clinical, neuropsychological and olfactory evaluation of a large family with LRRK2 mutations.
Lohmann E, Leclere L, De Anna F, Lesage S, Dubois B, Agid Y, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group
Parkinsonism Relat Disord. 2009
PubMed ID: 18718805
-
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
Sutherland GT, Halliday GM, Silburn PA, Mastaglia FL, Rowe DB, Boyle RS, O'Sullivan JD, Ly T, Wilton SD, Mellick GD
Mov Disord. 2009
PubMed ID: 19224617
-
Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations.
Camargos ST, Dornas LO, Momeni P, Lees A, Hardy J, Singleton A, Cardoso F
Mov Disord. 2009
PubMed ID: 19205068
-
The G2019S LRRK2 Mutation is Rare in Korean Patients with Parkinson's Disease and Multiple System Atrophy.
Cho JW, Kim SY, Park SS, Jeon BS
J Clin Neurol. 2009
PubMed ID: 19513331
-
The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation. Association with Parkinson disease, malignant melanoma and prevalence in ethnic groups in Israel.
Hassin-Baer S, Laitman Y, Azizi E, Molchadski I, Galore-Haskel G, Barak F, Cohen OS, Friedman E
J Neurol. 2009
PubMed ID: 19412725
-
Clinical and molecular neuroimaging characteristics of Brazilian patients with Parkinson's disease and mutations in PARK2 or PARK8 genes.
Barsottini OG, Felício AC, Aguiar Pde C, Godeiro-Junior C, Shih MC, Hoexter MQ, Bressan RA, Ferraz HB, Andrade LA
Arq Neuropsiquiatr. 2009
PubMed ID: 19330201
-
LRRK2 and neurodegeneration.
Santpere G, Ferrer I
Acta Neuropathol. 2009
PubMed ID: 19142648
-
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.
Ko HS, Bailey R, Smith WW, Liu Z, Shin JH, Lee YI, Zhang YJ, Jiang H, Ross CA, Moore DJ, Patterson C, Petrucelli L, Dawson TM, Dawson VL
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19196961
-
No TARDBP mutations in a French Canadian population of patients with Parkinson disease.
Kabashi E, Daoud H, Rivière JB, Valdmanis PN, Valdamanis PN, Bourgouin P, Provencher P, Pourcher E, Dion P, Dupré N, Rouleau GA
Arch Neurol. 2009
PubMed ID: 19204172
-
Common mutations in the LRRK2 exon 41 are not responsible for essential tremor in Italian patients.
Vitale C, Ciotti P, Gulli R, Bellone E, Scaglione C, Abbruzzese G, Martinelli P, Barone P, Mandich P
Parkinsonism Relat Disord. 2009
PubMed ID: 18556235
-
Sequence conservation between porcine and human LRRK2.
Larsen K, Madsen LB
Mol Biol Rep. 2009
PubMed ID: 17978862
-
Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.
Macedo MG, Verbaan D, Fang Y, van Rooden SM, Visser M, Anar B, Uras A, Groen JL, Rizzu P, van Hilten JJ, Heutink P
Mov Disord. 2009
PubMed ID: 18973254
-
The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.
Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT
J Neurosci. 2009
PubMed ID: 19176810
-
Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations.
Covy JP, Yuan W, Waxman EA, Hurtig HI, Van Deerlin VM, Giasson BI
Mov Disord. 2009
PubMed ID: 19006185
-
The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein.
Fu QS, Song AX, Li SX, Hu HY
Protein Pept Lett. 2009
PubMed ID: 20001906
-
Metabolomic profiling in LRRK2-related Parkinson's disease.
Johansen KK, Wang L, Aasly JO, White LR, Matson WR, Henchcliffe C, Beal MF, Bogdanov M
PLoS One. 2009
PubMed ID: 19847307
-
LRRK2 p.G2019S mutation is not common among Alzheimer's disease patients in Brazil.
Santos-Rebouças CB, Abdalla CB, Martins PA, Baldi FJ, Santos JM, Motta LB, de Borges MB, Souza DR, de Souza Pinhel MA, Laks J, Pimentel MM
Dis Markers. 2009
PubMed ID: 19822953
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.
Greggio E, Cookson MR
ASN Neuro. 2009
PubMed ID: 19570025
-
Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP.
Ding X, Goldberg MS
PLoS One. 2009
PubMed ID: 19536328
-
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Anand VS, Reichling LJ, Lipinski K, Stochaj W, Duan W, Kelleher K, Pungaliya P, Brown EL, Reinhart PH, Somberg R, Hirst WD, Riddle SM, Steven P B
FEBS J. 2009
PubMed ID: 19076219
-
[Advance of the study on LRRK2 gene in Parkinson's disease]
Zhang Y, Chen S
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
PubMed ID: 19065525
-
Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.
Devine MJ, Lewis PA
FEBS J. 2008
PubMed ID: 19021752
-
LRRK2 and parkin immunoreactivity in multiple system atrophy inclusions.
Huang Y, Song YJ, Murphy K, Holton JL, Lashley T, Revesz T, Gai WP, Halliday GM
Acta Neuropathol. 2008
PubMed ID: 18936941
-
Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Westerlund M, Ran C, Borgkvist A, Sterky FH, Lindqvist E, Lundströmer K, Pernold K, Brené S, Kallunki P, Fisone G, Olson L, Galter D
Mol Cell Neurosci. 2008
PubMed ID: 18790059
-
Progression of dopaminergic dysfunction in a LRRK2 kindred: a multitracer PET study.
Nandhagopal R, Mak E, Schulzer M, McKenzie J, McCormick S, Sossi V, Ruth TJ, Strongosky A, Farrer MJ, Wszolek ZK, Stoessl AJ
Neurology. 2008
PubMed ID: 19029519
-
LRRK2 G2019S and R1441G mutations associated with Parkinson's disease are common in the Basque Country, but relative prevalence is determined by ethnicity.
Gorostidi A, Ruiz-Martínez J, Lopez de Munain A, Alzualde A, Martí Massó JF
Neurogenetics. 2008
PubMed ID: 19020907
-
Is the common LRRK2 G2019S mutation related to dyskinesias in North African Parkinson disease?
Lesage S, Belarbi S, Troiano A, Condroyer C, Hecham N, Pollak P, Lohman E, Benhassine T, Ysmail-Dahlouk F, Dürr A, Tazir M, Brice A, French Parkinson's Disease Genetics Study Group
Neurology. 2008
PubMed ID: 18981379
-
LRRK2 mutations in patients with Parkinson's disease from Peru and Uruguay.
Mata IF, Cosentino C, Marca V, Torres L, Mazzetti P, Ortega O, Raggio V, Aljanati R, Buzó R, Yearout D, Dieguez E, Zabetian CP
Parkinsonism Relat Disord. 2008
PubMed ID: 18980856
-
LRRK2 P755L variant in sporadic Parkinson's disease.
Tomiyama H, Mizuta I, Li Y, Funayama M, Yoshino H, Li L, Murata M, Yamamoto M, Kubo SI, Mizuno Y, Toda T, Hattori N
J Hum Genet. 2008
PubMed ID: 18923807
-
LRRK2 mutations in Basque patients with Parkinson's disease.
Zarranz JJ, Gómez-Esteban JC
Lancet Neurol. 2008
PubMed ID: 18848304
-
LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.
Tan EK, Tan LC, Lim HQ, Li R, Tang M, Yih Y, Pavanni R, Prakash KM, Fook-Chong S, Zhao Y
Hum Genet. 2008
PubMed ID: 18781329
-
The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population.
Lu CS, Wu-Chou YH, van Doeselaar M, Simons EJ, Chang HC, Breedveld GJ, Di Fonzo A, Chen RS, Weng YH, Lai SC, Oostra BA, Bonifati V
Neurogenetics. 2008
PubMed ID: 18716801
-
Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease.
Choi JM, Woo MS, Ma HI, Kang SY, Sung YH, Yong SW, Chung SJ, Kim JS, Shin HW, Lyoo CH, Lee PH, Baik JS, Kim SJ, Park MY, Sohn YH, Kim JH, Kim JW, Lee MS, Lee MC, Kim DH, Kim YJ
Neurogenetics. 2008
PubMed ID: 18704525
-
Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway.
Liou AK, Leak RK, Li L, Zigmond MJ
Neurobiol Dis. 2008
PubMed ID: 18675914
-
Hyposmia in G2019S LRRK2-related parkinsonism: clinical and pathologic data.
Silveira-Moriyama L, Guedes LC, Kingsbury A, Ayling H, Shaw K, Barbosa ER, Bonifati V, Quinn NP, Abou-Sleiman P, Wood NW, Petrie A, Sampaio C, Ferreira JJ, Holton J, Revesz T, Lees AJ
Neurology. 2008
PubMed ID: 18809839
-
Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: Importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients.
Floris G, Cannas A, Solla P, Murru MR, Tranquilli S, Corongiu D, Rolesu M, Cuccu S, Sardu C, Marrosu F, Marrosu MG
Parkinsonism Relat Disord. 2008
PubMed ID: 18805725
-
Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra.
Han BS, Iacovitti L, Katano T, Hattori N, Seol W, Kim KS
Neurosci Lett. 2008
PubMed ID: 18634852
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.
Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B
EMBO J. 2008
PubMed ID: 18701920
-
Genetic screening of the G2019S mutation of the LRRK2 gene in Southwest European, North African, and Sephardic Jewish subjects.
Change N, Mercier G, Lucotte G
Genet Test. 2008
PubMed ID: 18666856
-
Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel.
Djaldetti R, Hassin-Baer S, Farrer MJ, Vilariño-Güell C, Ross OA, Kolianov V, Yust-Katz S, Treves TA, Barhum Y, Hulihan M, Melamed E
J Neural Transm. 2008
PubMed ID: 18665323
-
Is the G2019S LRRK2 mutation common in all southern European populations?
Papapetropoulos S, Adi N, Shehadeh L, Bishopric N, Singer C, Argyriou AA, Chroni E
J Clin Neurosci. 2008
PubMed ID: 18617409
-
LRRK2 gene G2019S mutation and SNPs [haplotypes] in subtypes of Parkinson's disease.
Patra B, Parsian AJ, Racette BA, Zhao JH, Perlmutter JS, Parsian A
Parkinsonism Relat Disord. 2008
PubMed ID: 18752982
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, NIDDK IBD Genetics Consortium, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Belgian-French IBD Consortium, Wellcome Trust Case Control Consortium, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ
Nat Genet. 2008
PubMed ID: 18587394
-
Screening for the LRRK2 G2019S and codon-1441 mutations in a pathological series of parkinsonian syndromes and frontotemporal lobar degeneration.
Gaig C, Ezquerra M, Martí MJ, Valldeoriola F, Muñoz E, Lladó A, Rey MJ, Cardozo A, Molinuevo JL, Tolosa E
J Neurol Sci. 2008
PubMed ID: 18353371
-
Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy.
De Rosa A, Criscuolo C, Mancini P, De Martino M, Giordano IA, Pappatà S, Filla A, De Michele G
Parkinsonism Relat Disord. 2008
PubMed ID: 18621566
-
LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study.
Hulihan MM, Ishihara-Paul L, Kachergus J, Warren L, Amouri R, Elango R, Prinjha RK, Upmanyu R, Kefi M, Zouari M, Sassi SB, Yahmed SB, El Euch-Fayeche G, Matthews PM, Middleton LT, Gibson RA, Hentati F, Farrer MJ
Lancet Neurol. 2008
PubMed ID: 18539535
-
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.
Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW, International LRRK2 Consortium
Lancet Neurol. 2008
PubMed ID: 18539534
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Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.
Lu YW, Tan EK
J Neurosci Res. 2008
PubMed ID: 18338801
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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.
Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR
J Biol Chem. 2008
PubMed ID: 18397888
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LRRK2 regulates synaptic vesicle endocytosis.
Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W
Exp Cell Res. 2008
PubMed ID: 18445495
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Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset.
Gan-Or Z, Giladi N, Rozovski U, Shifrin C, Rosner S, Gurevich T, Bar-Shira A, Orr-Urtreger A
Neurology. 2008
PubMed ID: 18434642
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LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies.
Lin CH, Tzen KY, Yu CY, Tai CH, Farrer MJ, Wu RM
J Biomed Sci. 2008
PubMed ID: 18523869
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LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients.
Chan DK, Ng PW, Mok V, Yeung J, Fang ZM, Clarke R, Leung E, Wong L
J Neural Transm. 2008
PubMed ID: 18523722
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The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules.
Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL
J Neurosci Res. 2008
PubMed ID: 18214993
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LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.
Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R
Neuropathol Appl Neurobiol. 2008
PubMed ID: 17971075
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Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia.
Mellick GD, Siebert GA, Funayama M, Buchanan DD, Li Y, Imamichi Y, Yoshino H, Silburn PA, Hattori N
Parkinsonism Relat Disord. 2008
PubMed ID: 18486522
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The prevalence of the G2019S and R1441C/G/H mutations in LRRK2 in German patients with Parkinson's disease.
Möller JC, Rissling I, Mylius V, Höft C, Eggert KM, Oertel WH
Eur J Neurol. 2008
PubMed ID: 18484993
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Genetic and environmental findings in early-onset Parkinson's disease Brazilian patients.
de Carvalho Aguiar P, Lessa PS, Junior CG, Barsottini O, Felício AC, Borges V, de Azevedo Silva SM, Saba RA, Ferraz HB, Moreira-Filho CA, Andrade LA
Mov Disord. 2008
PubMed ID: 18464276
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Recent advances in the genetics of dementia with lewy bodies.
Bonifati V
Curr Neurol Neurosci Rep. 2008
PubMed ID: 18541113
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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells.
Plowey ED, Cherra SJ, Liu YJ, Chu CT
J Neurochem. 2008
PubMed ID: 18182054
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RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player.
Häbig K, Walter M, Poths S, Riess O, Bonin M
Neurogenetics. 2008
PubMed ID: 18097693
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Analysis of the LRRK2 Gly2385Arg variant in primary dystonia and multiple system atrophy in Taiwan.
Lu CS, Chang HC, Weng YH, Chen RS, Bonifati V, Wu-Chou YH
Parkinsonism Relat Disord. 2008
PubMed ID: 18450497
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Screening for LRRK2 mutations in patients with Parkinson's disease in Russia: identification of a novel LRRK2 variant.
Pchelina SN, Yakimovskii AF, Emelyanov AK, Ivanova ON, Schwarzman AL, Singleton AB
Eur J Neurol. 2008
PubMed ID: 18435766
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Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.
Ross OA, Wu YR, Lee MC, Funayama M, Chen ML, Soto AI, Mata IF, Lee-Chen GJ, Chen CM, Tang M, Zhao Y, Hattori N, Farrer MJ, Tan EK, Wu RM
Ann Neurol. 2008
PubMed ID: 18412265
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Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.
Haugarvoll K, Rademakers R, Kachergus JM, Nuytemans K, Ross OA, Gibson JM, Tan EK, Gaig C, Tolosa E, Goldwurm S, Guidi M, Riboldazzi G, Brown L, Walter U, Benecke R, Berg D, Gasser T, Theuns J, Pals P, Cras P, De Deyn PP, Engelborghs S, Pickut B, Uitti RJ, Foroud T, Nichols WC, Hagenah J, Klein C, Samii A, Zabetian CP, Bonifati V, Van Broeckhoven C, Farrer MJ, Wszolek ZK
Neurology. 2008
PubMed ID: 18337586
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Pathogenicity of LRRK2 P755L variant in Parkinson's disease.
Tan EK, Lim HQ, Yuen Y, Zhao Y
Mov Disord. 2008
PubMed ID: 18265005
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Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism.
Moro E, Volkmann J, König IR, Winkler S, Hiller A, Hassin-Baer S, Herzog J, Schnitzler A, Lohmann K, Pinsker MO, Voges J, Djarmatic A, Seibler P, Lozano AM, Rogaeva E, Lang AE, Deuschl G, Klein C
Neurology. 2008
PubMed ID: 18378882
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Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls.
Paisán-Ruíz C, Nath P, Washecka N, Gibbs JR, Singleton AB
Hum Mutat. 2008
PubMed ID: 18213618
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Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients.
Nuytemans K, Rademakers R, Theuns J, Pals P, Engelborghs S, Pickut B, de Pooter T, Peeters K, Mattheijssens M, Van den Broeck M, Cras P, De Deyn PP, van Broeckhoven C
Eur J Hum Genet. 2008
PubMed ID: 18197194
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Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.
Westerlund M, Belin AC, Anvret A, Bickford P, Olson L, Galter D
Neuroscience. 2008
PubMed ID: 18272292
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Tremor dominant parkinsonism: Clinical description and LRRK2 mutation screening.
Clarimón J, Pagonabarraga J, Paisán-Ruíz C, Campolongo A, Pascual-Sedano B, Martí-Massó JF, Singleton AB, Kulisevsky J
Mov Disord. 2008
PubMed ID: 18098275
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A study of LRRK2 mutations and Parkinson's disease in Brazil.
Pimentel MM, Moura KC, Abdalla CB, Pereira JS, de Rosso AL, Nicaretta DH, Campos M, de Almeida RM, dos Santos JM, Bastos IC, Mendes MF, Maultasch H, Costa FH, Werneck AL, Santos-Rebouças CB
Neurosci Lett. 2008
PubMed ID: 18201824
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Essential tremor and the common LRRK2 G2385R variant.
Tan EK, Lee J, Lim HQ, Yuen Y, Zhao Y
Parkinsonism Relat Disord. 2008
PubMed ID: 18316234
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LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
An XK, Peng R, Li T, Burgunder JM, Wu Y, Chen WJ, Zhang JH, Wang YC, Xu YM, Gou YR, Yuan GG, Zhang ZJ
Eur J Neurol. 2008
PubMed ID: 18201193
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Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations.
Chen-Plotkin AS, Yuan W, Anderson C, McCarty Wood E, Hurtig HI, Clark CM, Miller BL, Lee VM, Trojanowski JQ, Grossman M, Van Deerlin VM
Neurology. 2008
PubMed ID: 17914064
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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.
Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18230735
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The G2019S LRRK2 mutation in Brazilian patients with Parkinson's disease: phenotype in monozygotic twins.
Munhoz RP, Wakutani Y, Marras C, Teive HA, Raskin S, Werneck LC, Moreno D, Sato C, Lang AE, Rogaeva E
Mov Disord. 2008
PubMed ID: 17999435
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The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study.
Latourelle JC, Sun M, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Goldwurm S, Pezzoli G, Zini M, Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Laramie JM, DeStefano AL, Baker KB, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH
BMC Med. 2008
PubMed ID: 18986508
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Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.
Okubadejo N, Britton A, Crews C, Akinyemi R, Hardy J, Singleton A, Bras J
PLoS ONE. 2008
PubMed ID: 18927607
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The biology and pathobiology of LRRK2: implications for Parkinson's disease.
Moore DJ
Parkinsonism Relat Disord. 2008
PubMed ID: 18602856
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ROCO kinase activity is controlled by internal GTPase function.
Weiss B
Sci Signal. 2008
PubMed ID: 18544747
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Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG
Neurodegener Dis. 2008
PubMed ID: 18322396
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Investigating convergent actions of genes linked to familial Parkinson's disease.
Wolozin B, Saha S, Guillily M, Ferree A, Riley M
Neurodegener Dis. 2008
PubMed ID: 18322385
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Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2.
Bras J, Guerreiro R, Ribeiro M, Morgadinho A, Januario C, Dias M, Calado A, Semedo C, Oliveira C, Hardy J, Singleton A
BMC Neurol. 2008
PubMed ID: 18211709
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Mutations in LRRK2 as a cause of Parkinson's disease.
Giasson BI, Van Deerlin VM
Neurosignals. 2008
PubMed ID: 18097165
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A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease.
Warren L, Gibson R, Ishihara L, Elango R, Xue Z, Akkari A, Ragone L, Pahwa R, Jankovic J, Nance M, Freeman A, Watts RL, Hentati F
Parkinsonism Relat Disord. 2008
PubMed ID: 17433753
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The prevalence of LRRK2 Gly2385Arg variant in Chinese Han population with Parkinson's disease.
Li C, Ting Z, Qin X, Ying W, Li B, Guo Qiang L, Jian Fang M, Jing Z, Jian Qing D, Sheng Di C
Mov Disord. 2007
PubMed ID: 17960808
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Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.
González-Fernández MC, Lezcano E, Ross OA, Gómez-Esteban JC, Gómez-Busto F, Velasco F, Alvarez-Alvarez M, Rodríguez-Martínez MB, Ciordia R, Zarranz JJ, Farrer MJ, Mata IF, de Pancorbo MM
Parkinsonism Relat Disord. 2007
PubMed ID: 17540608
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The role of common genetic risk variants in Parkinson disease.
Tan EK
Clin Genet. 2007
PubMed ID: 17868389
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No association between the LRRK2 G2019S mutation and Alzheimer's disease in Italy.
Tedde A, Bagnoli S, Cellini E, Nacmias B, Piacentini S, Sorbi S
Cell Mol Neurobiol. 2007
PubMed ID: 17846883
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LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.
Nichols WC, Elsaesser VE, Pankratz N, Pauciulo MW, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T, Parkinson Study Group-PROGENI Investigators
Neurology. 2007
PubMed ID: 17804834
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The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?
Orr-Urtreger A, Shifrin C, Rozovski U, Rosner S, Bercovich D, Gurevich T, Yagev-More H, Bar-Shira A, Giladi N
Neurology. 2007
PubMed ID: 17938369
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Neurocirculatory and nigrostriatal abnormalities in Parkinson disease from LRRK2 mutation.
Goldstein DS, Imrich R, Peckham E, Holmes C, Lopez G, Crews C, Hardy J, Singleton A, Hallett M
Neurology. 2007
PubMed ID: 17625107
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The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease.
Kalinderi K, Fidani L, Bostantjopoulou S, Katsarou Z, Kotsis A
Eur J Neurol. 2007
PubMed ID: 17880562
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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.
Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG
Exp Cell Res. 2007
PubMed ID: 17706965
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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.
Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z
J Neurochem. 2007
PubMed ID: 17623048
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LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease.
Bonifati V
Neurochem Res. 2007
PubMed ID: 17440812
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Analysis of LRRK2 Gly2385Arg genetic variant in non-Chinese Asians.
Tan EK, Zhao Y, Tan L, Lim HQ, Lee J, Yuen Y, Pavanni R, Wong MC, Fook-Chong S, Liu JJ
Mov Disord. 2007
PubMed ID: 17659642
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Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation.
Miklossy J, Qing H, Guo JP, Yu S, Wszolek ZK, Calne D, McGeer EG, McGeer PL
Acta Neuropathol. 2007
PubMed ID: 17639429
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Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation.
Luzón-Toro B, Rubio de la Torre E, Delgado A, Pérez-Tur J, Hilfiker S
Hum Mol Genet. 2007
PubMed ID: 17584768
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Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease.
Tan EK, Lee J, Chen CP, Wong MC, Zhao Y
Neurobiol Aging. 2007
PubMed ID: 17720280
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A novel LRRK2 mutation in an Austrian cohort of patients with Parkinson's disease.
Haubenberger D, Bonelli S, Hotzy C, Leitner P, Lichtner P, Samal D, Katzenschlager R, Djamshidian A, Brücke T, Steffelbauer M, Bancher C, Grossmann J, Ransmayr G, Strom TM, Meitinger T, Gasser T, Auff E, Zimprich A
Mov Disord. 2007
PubMed ID: 17523199
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LRRK2 screening in a Canadian Parkinson's disease cohort.
Grimes DA, Racacho L, Han F, Panisset M, Bulman DE
Can J Neurol Sci. 2007
PubMed ID: 17803033
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LRRK2 is not a significant cause of Parkinson's disease in French-Canadians.
Dupré N, Rivière JB, Myers RH, Provencher P, Pourcher E, Emond F, Rouleau GA
Can J Neurol Sci. 2007
PubMed ID: 17803032
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A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease.
Melrose HL, Kent CB, Taylor JP, Dachsel JC, Hinkle KM, Lincoln SJ, Mok SS, Culvenor JG, Masters CL, Tyndall GM, Bass DI, Ahmed Z, Andorfer CA, Ross OA, Wszolek ZK, Delldonne A, Dickson DW, Farrer MJ
Neuroscience. 2007
PubMed ID: 17611037
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Lrrk2 mutations in South America: A study of Chilean Parkinson's disease.
Perez-Pastene C, Cobb SA, Díaz-Grez F, Hulihan MM, Miranda M, Venegas P, Godoy OT, Kachergus JM, Ross OA, Layson L, Farrer MJ, Segura-Aguilar J
Neurosci Lett. 2007
PubMed ID: 17614198
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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.
Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR
Biochem J. 2007
PubMed ID: 17447891
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Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.
Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR
J Neurochem. 2007
PubMed ID: 17394548
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Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Higashi S, Biskup S, West AB, Trinkaus D, Dawson VL, Faull RL, Waldvogel HJ, Arai H, Dawson TM, Moore DJ, Emson PC
Brain Res. 2007
PubMed ID: 17512502
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High prevalence of LRRK2 mutations in familial and sporadic Parkinson's disease in Portugal.
Ferreira JJ, Guedes LC, Rosa MM, Coelho M, van Doeselaar M, Schweiger D, Di Fonzo A, Oostra BA, Sampaio C, Bonifati V
Mov Disord. 2007
PubMed ID: 17469194
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The R1441C mutation of LRRK2 disrupts GTP hydrolysis.
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, Cookson MR
Biochem Biophys Res Commun. 2007
PubMed ID: 17442267
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Apoptotic mechanisms in mutant LRRK2-mediated cell death.
Iaccarino C, Crosio C, Vitale C, Sanna G, Carrì MT, Barone P
Hum Mol Genet. 2007
PubMed ID: 17409193
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Genetic analysis of LRRK2 P755L variant in Caucasian patients with Parkinson's disease.
Deng H, Le W, Huang M, Xie W, Pan T, Jankovic J
Neurosci Lett. 2007
PubMed ID: 17482357
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Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease.
Huang Y, Halliday GM, Vandebona H, Mellick GD, Mastaglia F, Stevens J, Kwok J, Garlepp M, Silburn PA, Horne MK, Kotschet K, Venn A, Rowe DB, Rubio JP, Sue CM
Mov Disord. 2007
PubMed ID: 17427941
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MAPK-pathway activity, Lrrk2 G2019S, and Parkinson's disease.
White LR, Toft M, Kvam SN, Farrer MJ, Aasly JO
J Neurosci Res. 2007
PubMed ID: 17385669
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Parkin polymorphisms and environmental exposure: decrease in age at onset of Parkinson's disease.
Ghione I, Di Fonzo A, Saladino F, Del Bo R, Bresolin N, Comi GP, Rango M
Neurotoxicology. 2007
PubMed ID: 17335904
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Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Dächsel JC, Ross OA, Mata IF, Kachergus J, Toft M, Cannon A, Baker M, Adamson J, Hutton M, Dickson DW, Farrer MJ
Acta Neuropathol. 2007
PubMed ID: 17151837
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Common variants in Parkinson's disease.
Ross OA, Farrer MJ, Wu RM
Mov Disord. 2007
PubMed ID: 17377919
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Independent occurrence of I2020T mutation in the kinase domain of the leucine rich repeat kinase 2 gene in Japanese and German Parkinson's disease families.
Ohta E, Hasegawa K, Gasser T, Obata F
Neurosci Lett. 2007
PubMed ID: 17395370
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Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway.
Haugarvoll K, Toft M, Ross OA, White LR, Aasly JO, Farrer MJ
Neurosci Lett. 2007
PubMed ID: 17324517
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Evaluation of LRRK2 G2019S penetrance: relevance for genetic counseling in Parkinson disease.
Goldwurm S, Zini M, Mariani L, Tesei S, Miceli R, Sironi F, Clementi M, Bonifati V, Pezzoli G
Neurology. 2007
PubMed ID: 17215492
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LRRK2 G6055A mutation in Italian patients with familial or sporadic Parkinson's disease.
Civitelli D, Tarantino P, Nicoletti G, Cirò Candiano IC, Annesi F, De Marco EV, Carrideo S, Rocca FE, Condino F, Spadafora P, Pugliese P, D'Asero S, Morelli M, Paglionico S, Annesi G, Quattrone A
Clin Genet. 2007
PubMed ID: 17470139
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A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia.
Illarioshkin SN, Shadrina MI, Slominsky PA, Bespalova EV, Zagorovskaya TB, Bagyeva GKh, Markova ED, Limborska SA, Ivanova-Smolenskaya IA
Eur J Neurol. 2007
PubMed ID: 17388990
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Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease.
Taylor JP, Hulihan MM, Kachergus JM, Melrose HL, Lincoln SJ, Hinkle KM, Stone JT, Ross OA, Hauser R, Aasly J, Gasser T, Payami H, Wszolek ZK, Farrer MJ
Neurogenetics. 2007
PubMed ID: 17225181
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Leucine-rich repeat kinase 2 associates with lipid rafts.
Hatano T, Kubo S, Imai S, Maeda M, Ishikawa K, Mizuno Y, Hattori N
Hum Mol Genet. 2007
PubMed ID: 17341485
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G2019S mutation in the leucine-rich repeat kinase 2 gene is not associated with multiple system atrophy.
Ozelius LJ, Foroud T, May S, Senthil G, Sandroni P, Low PA, Reich S, Colcher A, Stern MB, Ondo WG, Jankovic J, Huang N, Tanner CM, Novak P, Gilman S, Marshall FJ, Wooten GF, Chelimsky TC, Shults CW, North American Multiple System Atrophy Study Group
Mov Disord. 2007
PubMed ID: 17230458
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Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
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LRRK2 exon 41 mutations in sporadic Parkinson disease in Europeans.
Lesage S, Janin S, Lohmann E, Leutenegger AL, Leclere L, Viallet F, Pollak P, Durif F, Thobois S, Layet V, Vidailhet M, Agid Y, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group, Bonnet AM, Borg M, Broussolle E, Damier P, Destée A, Martinez M, Penet C, Rasco O, Tison F, Tranchan C, Vérin M
Arch Neurol. 2007
PubMed ID: 17353388
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Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.
Farrer MJ, Stone JT, Lin CH, Dächsel JC, Hulihan MM, Haugarvoll K, Ross OA, Wu RM
Parkinsonism Relat Disord. 2007
PubMed ID: 17222580
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Pathogenic Lrrk2 substitutions and Amyotrophic lateral sclerosis.
Whittle AJ, Ross OA, Naini A, Gordon P, Mistumoto H, Dächsel JC, Stone JT, Wszolek ZK, Farrer MJ, Przedborski S
J Neural Transm. 2007
PubMed ID: 16865326
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Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease.
Toft M, Mata IF, Ross OA, Kachergus J, Hulihan MM, Haugarvoll K, Stone JT, Blazquez M, Gibson JM, Aasly JO, White LR, Lynch T, Adler CH, Gwinn-Hardy K, Farrer MJ
Mov Disord. 2007
PubMed ID: 17216639
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Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
Funayama M, Li Y, Tomiyama H, Yoshino H, Imamichi Y, Yamamoto M, Murata M, Toda T, Mizuno Y, Hattori N
Neuroreport. 2007
PubMed ID: 17314670
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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T
Biochemistry. 2007
PubMed ID: 17260967
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The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease.
Cho JW, Kim SY, Park SS, Kim HJ, Ahn TB, Kim JM, Jeon BS
Can J Neurol Sci. 2007
PubMed ID: 17352347
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The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.
Tan EK, Zhao Y, Skipper L, Tan MG, Di Fonzo A, Sun L, Fook-Chong S, Tang S, Chua E, Yuen Y, Tan L, Pavanni R, Wong MC, Kolatkar P, Lu CS, Bonifati V, Liu JJ
Hum Genet. 2007
PubMed ID: 17019612
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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.
West AB, Moore DJ, Choi C, Andrabi SA, Li X, Dikeman D, Biskup S, Zhang Z, Lim KL, Dawson VL, Dawson TM
Hum Mol Genet. 2007
PubMed ID: 17200152
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R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation.
Nichols WC, Marek DK, Pauciulo MW, Pankratz N, Halter CA, Rudolph A, Shults CW, Wojcieszek J, Foroud T, Parkinson Study Group - PROGENI Investigators
Mov Disord. 2007
PubMed ID: 17149721
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[A PARK8 form of Parkinson's disease: a mutational analysis of the LRRK2 gene in Russian population.]
Shadrina MI, Illarioshkin SN, Bagyeva GK, Bespalova EV, Zagorovskaia TB, Slominskiĭ PA, Markova ED, Kliushnikov SA, Limborskaia SA, Ivanova-Smolenskaia IA
Zh Nevrol Psikhiatr Im S S Korsakova. 2007
PubMed ID: 18379513
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Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
Biskup S, Moore DJ, Rea A, Lorenz-Deperieux B, Coombes CE, Dawson VL, Dawson TM, West AB
BMC Neurosci. 2007
PubMed ID: 18045479
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The full-ORF clone resource of the German cDNA Consortium.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC Genomics. 2007
PubMed ID: 17974005
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Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation.
Johnson J, Paisán-Ruíz C, Lopez G, Crews C, Britton A, Malkani R, Evans EW, McInerney-Leo A, Jain S, Nussbaum RL, Foote KD, Mandel RJ, Crawley A, Reimsnider S, Fernandez HH, Okun MS, Gwinn-Hardy K, Singleton AB
Neurodegener Dis. 2007
PubMed ID: 17622782
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Frequency of the LRRK2 G2019S mutation in siblings with Parkinson's disease.
Lesage S, Leclere L, Lohmann E, Borg M, Ruberg M, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group
Neurodegener Dis. 2007
PubMed ID: 17596714
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LRRK2 and Parkinson's disease in Norway.
Toft M, Haugarvoll K, Ross OA, Farrer MJ, Aasly JO
Acta Neurol Scand Suppl. 2007
PubMed ID: 17419834
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Frequency of the LRRK2 G2019S mutation in Italian patients affected by Parkinson's disease.
Squillaro T, Cambi F, Ciacci G, Rossi S, Ulivelli M, Malandrini A, Mencarelli MA, Mari F, Renieri A, Ariani F
J Hum Genet. 2007
PubMed ID: 17235449
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Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants.
Xiromerisiou G, Hadjigeorgiou GM, Gourbali V, Johnson J, Papakonstantinou I, Papadimitriou A, Singleton AB
Eur J Neurol. 2007
PubMed ID: 17222106
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Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.
Ishihara L, Gibson RA, Warren L, Amouri R, Lyons K, Wielinski C, Hunter C, Swartz JE, Elango R, Akkari PA, Leppert D, Surh L, Reeves KH, Thomas S, Ragone L, Hattori N, Pahwa R, Jankovic J, Nance M, Freeman A, Gouider-Khouja N, Kefi M, Zouari M, Ben Sassi S, Ben Yahmed S, El Euch-Fayeche G, Middleton L, Burn DJ, Watts RL, Hentati F
Mov Disord. 2007
PubMed ID: 17115391
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Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.
Higashi S, Moore DJ, Colebrooke RE, Biskup S, Dawson VL, Arai H, Dawson TM, Emson PC
J Neurochem. 2007
PubMed ID: 17101029
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LRRK2 G2019S founder haplotype in the Chinese population.
Tan EK, Skipper L, Tan L, Liu JJ
Mov Disord. 2007
PubMed ID: 17083102
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Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations.
Schüpbach M, Lohmann E, Anheim M, Lesage S, Czernecki V, Yaici S, Worbe Y, Charles P, Welter ML, Pollak P, Dürr A, Agid Y, Brice A
Mov Disord. 2007
PubMed ID: 17080443
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Genetic analysis of LRRK2 mutations in patients with Parkinson disease.
Deng H, Le W, Guo Y, Hunter CB, Xie W, Huang M, Jankovic J
J Neurol Sci. 2006
PubMed ID: 17097110
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A novel P755L mutation in LRRK2 gene associated with Parkinson's disease.
Wu T, Zeng Y, Ding X, Li X, Li W, Dong H, Chen S, Zhang X, Ma G, Yao J, Deng X
Neuroreport. 2006
PubMed ID: 17179858
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LRRK2 mutations in a clinic-based cohort of Parkinson's disease.
Scholz S, Mandel RJ, Fernandez HH, Foote KD, Rodriguez RL, Barton E, Munson S, Singleton A, Okun MS
Eur J Neurol. 2006
PubMed ID: 17116211
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Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease.
Pankratz N, Pauciulo MW, Elsaesser VE, Marek DK, Halter CA, Rudolph A, Shults CW, Foroud T, Nichols WC, Parkinson Study Group-PROGENI Investigators
Mov Disord. 2006
PubMed ID: 17078063
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Absence/rarity of commonly reported LRRK2 mutations in Indian Parkinson's disease patients.
Punia S, Behari M, Govindappa ST, Swaminath PV, Jayaram S, Goyal V, Muthane UB, Juyal RC, Thelma BK
Neurosci Lett. 2006
PubMed ID: 17052850
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G2019S LRRK2 mutation in familial and sporadic Parkinson's disease in Russia.
Pchelina SN, Yakimovskii AF, Ivanova ON, Emelianov AK, Zakharchuk AH, Schwarzman AL
Mov Disord. 2006
PubMed ID: 17044089
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The Parkinson disease gene LRRK2: evolutionary and structural insights.
Marín I
Mol Biol Evol. 2006
PubMed ID: 16966681
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Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.
Clark LN, Wang Y, Karlins E, Saito L, Mejia-Santana H, Harris J, Louis ED, Cote LJ, Andrews H, Fahn S, Waters C, Ford B, Frucht S, Ottman R, Marder K
Neurology. 2006
PubMed ID: 17050822
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The familial Parkinsonism gene LRRK2 regulates neurite process morphology.
MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A
Neuron. 2006
PubMed ID: 17114044
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Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease.
Tan EK
Ann Acad Med Singapore. 2006
PubMed ID: 17160203
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Localization of LRRK2 to membranous and vesicular structures in mammalian brain.
Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL
Ann Neurol. 2006
PubMed ID: 17120249
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Parkinson's disease due to the R1441G mutation in Dardarin: a founder effect in the Basques.
Simón-Sánchez J, Martí-Massó JF, Sánchez-Mut JV, Paisán-Ruiz C, Martínez-Gil A, Ruiz-Martínez J, Sáenz A, Singleton AB, López de Munain A, Pérez-Tur J
Mov Disord. 2006
PubMed ID: 16991141
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LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP.
Spanaki C, Latsoudis H, Plaitakis A
Neurology. 2006
PubMed ID: 17060595
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The LRRK2 I2012T, G2019S and I2020T mutations are not common in patients with essential tremor.
Deng H, Le W, Davidson AL, Xie W, Jankovic J
Neurosci Lett. 2006
PubMed ID: 16939701
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Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA
Nat Neurosci. 2006
PubMed ID: 16980962
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Leucine-rich repeat kinase 2 (LRRK2) mutations in a Swedish Parkinson cohort and a healthy nonagenarian.
Carmine Belin A, Westerlund M, Sydow O, Lundströmer K, Håkansson A, Nissbrandt H, Olson L, Galter D
Mov Disord. 2006
PubMed ID: 16817197
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LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample.
Goldwurm S, Zini M, Di Fonzo A, De Gaspari D, Siri C, Simons EJ, van Doeselaar M, Tesei S, Antonini A, Canesi M, Zecchinelli A, Mariani C, Meucci N, Sacilotto G, Cilia R, Isaias IU, Bonetti A, Sironi F, Ricca S, Oostra BA, Bonifati V, Pezzoli G
Parkinsonism Relat Disord. 2006
PubMed ID: 16750929
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Clinical features of Parkinson disease patients with homozygous leucine-rich repeat kinase 2 G2019S mutations.
Ishihara L, Warren L, Gibson R, Amouri R, Lesage S, Dürr A, Tazir M, Wszolek ZK, Uitti RJ, Nichols WC, Griffith A, Hattori N, Leppert D, Watts R, Zabetian CP, Foroud TM, Farrer MJ, Brice A, Middleton L, Hentati F
Arch Neurol. 2006
PubMed ID: 16966502
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Clinical heterogeneity of the LRRK2 G2019S mutation.
Papapetropoulos S, Singer C, Ross OA, Toft M, Johnson JL, Farrer MJ, Mash DC
Arch Neurol. 2006
PubMed ID: 16966501
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The importance of LRRK2 mutations in Parkinson disease.
Schapira AH
Arch Neurol. 2006
PubMed ID: 16966498
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The pleomorphic pathology of inherited Parkinson's disease: lessons from LRRK2.
Bonifati V
Curr Neurol Neurosci Rep. 2006
PubMed ID: 16928343
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Recurrent LRRK2 (Park8) mutations in early-onset Parkinson's disease.
Hedrich K, Winkler S, Hagenah J, Kabakci K, Kasten M, Schwinger E, Volkmann J, Pramstaller PP, Kostic V, Vieregge P, Klein C
Mov Disord. 2006
PubMed ID: 16758483
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Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients.
Nakamura N, Shimaoka Y, Tougan T, Onda H, Okuzaki D, Zhao H, Fujimori A, Yabuta N, Nagamori I, Tanigawa A, Sato J, Oda T, Hayashida K, Suzuki R, Yukioka M, Nojima H, Ochi T
DNA Res. 2006
PubMed ID: 17082220
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Identification and haplotype analysis of LRRK2 G2019S in Japanese patients with Parkinson disease.
Zabetian CP, Morino H, Ujike H, Yamamoto M, Oda M, Maruyama H, Izumi Y, Kaji R, Griffith A, Leis BC, Roberts JW, Yearout D, Samii A, Kawakami H
Neurology. 2006
PubMed ID: 16728648
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Glucocerebrosidase mutations are not found in association with LRRK2 G2019S in subjects with parkinsonism.
Eblan MJ, Scholz S, Stubblefield B, Gutti U, Goker-Alpan O, Hruska KS, Singleton AB, Sidransky E
Neurosci Lett. 2006
PubMed ID: 16781064
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Distribution of PINK1 and LRRK2 in rat and mouse brain.
Taymans JM, Van den Haute C, Baekelandt V
J Neurochem. 2006
PubMed ID: 16771836
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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR
Neurobiol Dis. 2006
PubMed ID: 16750377
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Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation.
Isaias IU, Benti R, Goldwurm S, Zini M, Cilia R, Gerundini P, Di Fonzo A, Bonifati V, Pezzoli G, Antonini A
Mov Disord. 2006
PubMed ID: 16671078
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Frequency and phenotypes of LRRK2 G2019S mutation in Italian patients with Parkinson's disease.
Marongiu R, Ghezzi D, Ialongo T, Soleti F, Elia A, Cavone S, Albanese A, Altavista MC, Barone P, Brusa L, Cortelli P, Petrozzi L, Scaglione C, Stanzione P, Tinazzi M, Zeviani M, Dallapiccola B, Bentivoglio AR, Valente EM, Garavaglia B, Italian PD Study Group
Mov Disord. 2006
PubMed ID: 16622859
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Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries.
Tomiyama H, Li Y, Funayama M, Hasegawa K, Yoshino H, Kubo S, Sato K, Hattori T, Lu CS, Inzelberg R, Djaldetti R, Melamed E, Amouri R, Gouider-Khouja N, Hentati F, Hatano Y, Wang M, Imamichi Y, Mizoguchi K, Miyajima H, Obata F, Toda T, Farrer MJ, Mizuno Y, Hattori N
Mov Disord. 2006
PubMed ID: 16622854
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Increased frequency of the LRRK2 G2019S mutation in an elderly Ashkenazi Jewish population is not associated with dementia.
Saunders-Pullman R, Lipton RB, Senthil G, Katz M, Costan-Toth C, Derby C, Bressman S, Verghese J, Ozelius LJ
Neurosci Lett. 2006
PubMed ID: 16632201
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PARK8 LRRK2 parkinsonism.
Haugarvoll K, Wszolek ZK
Curr Neurol Neurosci Rep. 2006
PubMed ID: 16822348
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A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.
Di Fonzo A, Wu-Chou YH, Lu CS, van Doeselaar M, Simons EJ, Rohé CF, Chang HC, Chen RS, Weng YH, Vanacore N, Breedveld GJ, Oostra BA, Bonifati V
Neurogenetics. 2006
PubMed ID: 16633828
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Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
Tan EK, Skipper L, Chua E, Wong MC, Pavanni R, Bonnard C, Kolatkar P, Liu JJ
Mov Disord. 2006
PubMed ID: 16602113
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Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease.
Fung HC, Chen CM, Hardy J, Hernandez D, Singleton A, Wu YR
Mov Disord. 2006
PubMed ID: 16511860
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LRRK2 in Parkinson's disease: protein domains and functional insights.
Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA
Trends Neurosci. 2006
PubMed ID: 16616379
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Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.
Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA
J Neurol Neurosurg Psychiatry. 2006
PubMed ID: 16614029
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LRRK2 mutations are a common cause of Parkinson's disease in Spain.
Mata IF, Ross OA, Kachergus J, Huerta C, Ribacoba R, Moris G, Blazquez M, Guisasola LM, Salvador C, Martinez C, Farrer M, Alvarez V
Eur J Neurol. 2006
PubMed ID: 16643318
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LRRK2 expression linked to dopamine-innervated areas.
Galter D, Westerlund M, Carmine A, Lindqvist E, Sydow O, Olson L
Ann Neurol. 2006
PubMed ID: 16532471
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Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics.
Kay DM, Zabetian CP, Factor SA, Nutt JG, Samii A, Griffith A, Bird TD, Kramer P, Higgins DS, Payami H
Mov Disord. 2006
PubMed ID: 16250030
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The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
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LRRK2 G2019S is a common mutation in Spanish patients with late-onset Parkinson's disease.
Infante J, Rodríguez E, Combarros O, Mateo I, Fontalba A, Pascual J, Oterino A, Polo JM, Leno C, Berciano J
Neurosci Lett. 2006
PubMed ID: 16298482
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LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance.
Gaig C, Ezquerra M, Marti MJ, Muñoz E, Valldeoriola F, Tolosa E
Arch Neurol. 2006
PubMed ID: 16533964
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Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease.
Di Fonzo A, Tassorelli C, De Mari M, Chien HF, Ferreira J, Rohé CF, Riboldazzi G, Antonini A, Albani G, Mauro A, Marconi R, Abbruzzese G, Lopiano L, Fincati E, Guidi M, Marini P, Stocchi F, Onofrj M, Toni V, Tinazzi M, Fabbrini G, Lamberti P, Vanacore N, Meco G, Leitner P, Uitti RJ, Wszolek ZK, Gasser T, Simons EJ, Breedveld GJ, Goldwurm S, Pezzoli G, Sampaio C, Barbosa E, Martignoni E, Oostra BA, Bonifati V, Italian Parkinson's Genetics Network
Eur J Hum Genet. 2006
PubMed ID: 16333314
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LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain.
Simón-Sánchez J, Herranz-Pérez V, Olucha-Bordonau F, Pérez-Tur J
Eur J Neurosci. 2006
PubMed ID: 16487147
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Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium.
Paisán-Ruíz C, Evans EW, Jain S, Xiromerisiou G, Gibbs JR, Eerola J, Gourbali V, Hellström O, Duckworth J, Papadimitriou A, Tienari PJ, Hadjigeorgiou GM, Singleton AB
J Med Genet. 2006
PubMed ID: 16467219
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Lrrk2 and Lewy body disease.
Ross OA, Toft M, Whittle AJ, Johnson JL, Papapetropoulos S, Mash DC, Litvan I, Gordon MF, Wszolek ZK, Farrer MJ, Dickson DW
Ann Neurol. 2006
PubMed ID: 16437559
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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.
Ozelius LJ, Senthil G, Saunders-Pullman R, Ohmann E, Deligtisch A, Tagliati M, Hunt AL, Klein C, Henick B, Hailpern SM, Lipton RB, Soto-Valencia J, Risch N, Bressman SB
N Engl J Med. 2006
PubMed ID: 16436782
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LRRK2 G2019S as a cause of Parkinson's disease in North African Arabs.
Lesage S, Dürr A, Tazir M, Lohmann E, Leutenegger AL, Janin S, Pollak P, Brice A, French Parkinson's Disease Genetics Study Group
N Engl J Med. 2006
PubMed ID: 16436781
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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.
Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M
Hum Mol Genet. 2006
PubMed ID: 16321986
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Genetic screening for two LRRK2 mutations in French patients with idiopathic Parkinson's disease.
Funalot B, Nichols WC, Pérez-Tur J, Mercier G, Lucotte G
Genet Test. 2006
PubMed ID: 17253937
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A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan.
Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR
BMC Neurol. 2006
PubMed ID: 17187665
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Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease.
Kay DM, Bird TD, Zabetian CP, Factor SA, Samii A, Higgins DS, Nutt J, Roberts JW, Griffith A, Leis BC, Montimurro JS, Philpott S, Payami H
Genet Test. 2006
PubMed ID: 17020475
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Molecular genetic findings in LRRK2 American, Canadian and German families.
Gasser T
J Neural Transm Suppl. 2006
PubMed ID: 17017534
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Clinical and pathologic features of families with LRRK2-associated Parkinson's disease.
Whaley NR, Uitti RJ, Dickson DW, Farrer MJ, Wszolek ZK
J Neural Transm Suppl. 2006
PubMed ID: 17017533
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Anatomical localization of leucine-rich repeat kinase 2 in mouse brain.
Melrose H, Lincoln S, Tyndall G, Dickson D, Farrer M
Neuroscience. 2006
PubMed ID: 16504409
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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.
Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16352719
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Analysis of LRRK 2 G 2019 S and I 2020 T mutations in Parkinson's disease.
Bialecka M, Hui S, Klodowska-Duda G, Opala G, Tan EK, Drozdzik M
Neurosci Lett. 2005
PubMed ID: 16115731
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The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases.
Hernandez D, Paisan Ruiz C, Crawley A, Malkani R, Werner J, Gwinn-Hardy K, Dickson D, Wavrant Devrieze F, Hardy J, Singleton A
Neurosci Lett. 2005
PubMed ID: 16102903
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Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data.
Khan NL, Jain S, Lynch JM, Pavese N, Abou-Sleiman P, Holton JL, Healy DG, Gilks WP, Sweeney MG, Ganguly M, Gibbons V, Gandhi S, Vaughan J, Eunson LH, Katzenschlager R, Gayton J, Lennox G, Revesz T, Nicholl D, Bhatia KP, Quinn N, Brooks D, Lees AJ, Davis MB, Piccini P, Singleton AB, Wood NW
Brain. 2005
PubMed ID: 16272164
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Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease.
Skipper L, Li Y, Bonnard C, Pavanni R, Yih Y, Chua E, Sung WK, Tan L, Wong MC, Tan EK, Liu J
Hum Mol Genet. 2005
PubMed ID: 16269443
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Common variants of LRRK2 are not associated with sporadic Parkinson's disease.
Biskup S, Mueller JC, Sharma M, Lichtner P, Zimprich A, Berg D, Wüllner U, Illig T, Meitinger T, Gasser T
Ann Neurol. 2005
PubMed ID: 16254973
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Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.
Berg D, Schweitzer K, Leitner P, Zimprich A, Lichtner P, Belcredi P, Brussel T, Schulte C, Maass S, Nagele T
Brain. 2005
PubMed ID: 16251215
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Lrrk2 pathogenic substitutions in Parkinson's disease.
Mata IF, Kachergus JM, Taylor JP, Lincoln S, Aasly J, Lynch T, Hulihan MM, Cobb SA, Wu RM, Lu CS, Lahoz C, Wszolek ZK, Farrer MJ
Neurogenetics. 2005
PubMed ID: 16172858
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G2019S dardarin substitution is a common cause of Parkinson's disease in a Portuguese cohort.
Bras JM, Guerreiro RJ, Ribeiro MH, Januario C, Morgadinho A, Oliveira CR, Cunha L, Hardy J, Singleton A
Mov Disord. 2005
PubMed ID: 16149095
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PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.
Adams JR, van Netten H, Schulzer M, Mak E, Mckenzie J, Strongosky A, Sossi V, Ruth TJ, Lee CS, Farrer M, Gasser T, Uitti RJ, Calne DB, Wszolek ZK, Stoessl AJ
Brain. 2005
PubMed ID: 16081470
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Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis.
Li C, Beal MF
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16275903
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16269541
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The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.
Goldwurm S, Di Fonzo A, Simons EJ, Rohé CF, Zini M, Canesi M, Tesei S, Zecchinelli A, Antonini A, Mariani C, Meucci N, Sacilotto G, Sironi F, Salani G, Ferreira J, Chien HF, Fabrizio E, Vanacore N, Dalla Libera A, Stocchi F, Diroma C, Lamberti P, Sampaio C, Meco G, Barbosa E, Bertoli-Avella AM, Breedveld GJ, Oostra BA, Pezzoli G, Bonifati V
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PubMed ID: 16272257
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G2019S LRRK2 mutation in French and North African families with Parkinson's disease.
Lesage S, Ibanez P, Lohmann E, Pollak P, Tison F, Tazir M, Leutenegger AL, Guimaraes J, Bonnet AM, Agid Y, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group
Ann Neurol. 2005
PubMed ID: 16240353
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LRRK2 mutations are not common in Alzheimer's disease.
Toft M, Sando SB, Melquist S, Ross OA, White LR, Aasly JO, Farrer MJ
Mech Ageing Dev. 2005
PubMed ID: 16087219
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Analysis of LRRK2 functional domains in nondominant Parkinson disease.
Skipper L, Shen H, Chua E, Bonnard C, Kolatkar P, Tan LC, Jamora RD, Puvan K, Puong KY, Zhao Y, Pavanni R, Wong MC, Yuen Y, Farrer M, Liu JJ, Tan EK
Neurology. 2005
PubMed ID: 16247070
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A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations.
Zabetian CP, Samii A, Mosley AD, Roberts JW, Leis BC, Yearout D, Raskind WH, Griffith A
Neurology. 2005
PubMed ID: 16157909
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LRRK2 mutations in Parkinson disease.
Farrer M, Stone J, Mata IF, Lincoln S, Kachergus J, Hulihan M, Strain KJ, Maraganore DM
Neurology. 2005
PubMed ID: 16157908
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LRRK2 gene in Parkinson disease: mutation analysis and case control association study.
Paisán-Ruíz C, Lang AE, Kawarai T, Sato C, Salehi-Rad S, Fisman GK, Al-Khairallah T, St George-Hyslop P, Singleton A, Rogaeva E
Neurology. 2005
PubMed ID: 16157901
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Antisense transcription in the mammalian transcriptome.
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Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
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Science. 2005
PubMed ID: 16141072
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Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD.
Gosal D, Ross OA, Wiley J, Irvine GB, Johnston JA, Toft M, Mata IF, Kachergus J, Hulihan M, Taylor JP, Lincoln SJ, Farrer MJ, Lynch T, Mark Gibson J
Parkinsonism Relat Disord. 2005
PubMed ID: 16102999
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The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients.
Tan EK, Shen H, Tan LC, Farrer M, Yew K, Chua E, Jamora RD, Puvan K, Puong KY, Zhao Y, Pavanni R, Wong MC, Yih Y, Skipper L, Liu JJ
Neurosci Lett. 2005
PubMed ID: 15955629
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LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century.
Lesage S, Leutenegger AL, Ibanez P, Janin S, Lohmann E, Dürr A, Brice A, French Parkinson's Disease Genetics Study Group
Am J Hum Genet. 2005
PubMed ID: 16145815
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Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation.
Kay DM, Kramer P, Higgins D, Zabetian CP, Payami H
Mov Disord. 2005
PubMed ID: 16001413
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Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin.
Singleton AB
Trends Neurosci. 2005
PubMed ID: 15955578
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LRRK2 R1441G in Spanish patients with Parkinson's disease.
Mata IF, Taylor JP, Kachergus J, Hulihan M, Huerta C, Lahoz C, Blazquez M, Guisasola LM, Salvador C, Ribacoba R, Martinez C, Farrer M, Alvarez V
Neurosci Lett. 2005
PubMed ID: 15925109
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Genetic testing in Parkinson's disease.
McInerney-Leo A
Mov Disord. 2005
PubMed ID: 15884041
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Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation.
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Ann Neurol. 2005
PubMed ID: 15929036
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An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.
Funayama M, Hasegawa K, Ohta E, Kawashima N, Komiyama M, Kowa H, Tsuji S, Obata F
Ann Neurol. 2005
PubMed ID: 15880653
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Clinical features of LRRK2-associated Parkinson's disease in central Norway.
Aasly JO, Toft M, Fernandez-Mata I, Kachergus J, Hulihan M, White LR, Farrer M
Ann Neurol. 2005
PubMed ID: 15852371
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LRRK2 mutations and Parkinsonism.
Toft M, Mata IF, Kachergus JM, Ross OA, Farrer MJ
Lancet. 2005
PubMed ID: 15811454
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Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
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Am J Hum Genet. 2005
PubMed ID: 15726496
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Clinical and positron emission tomography of Parkinson's disease caused by LRRK2.
Hernandez DG, Paisán-Ruíz C, McInerney-Leo A, Jain S, Meyer-Lindenberg A, Evans EW, Berman KF, Johnson J, Auburger G, Schäffer AA, Lopez GJ, Nussbaum RL, Singleton AB
Ann Neurol. 2005
PubMed ID: 15732108
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A common LRRK2 mutation in idiopathic Parkinson's disease.
Gilks WP, Abou-Sleiman PM, Gandhi S, Jain S, Singleton A, Lees AJ, Shaw K, Bhatia KP, Bonifati V, Quinn NP, Lynch J, Healy DG, Holton JL, Revesz T, Wood NW
Lancet. 2005
PubMed ID: 15680457
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A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.
Di Fonzo A, Rohé CF, Ferreira J, Chien HF, Vacca L, Stocchi F, Guedes L, Fabrizio E, Manfredi M, Vanacore N, Goldwurm S, Breedveld G, Sampaio C, Meco G, Barbosa E, Oostra BA, Bonifati V, Italian Parkinson Genetics Network
Lancet. 2005
PubMed ID: 15680456
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Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.
Nichols WC, Pankratz N, Hernandez D, Paisán-Ruíz C, Jain S, Halter CA, Michaels VE, Reed T, Rudolph A, Shults CW, Singleton A, Foroud T, Parkinson Study Group-PROGENI investigators
Lancet. 2005
PubMed ID: 15680455
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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
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Neuron. 2004
PubMed ID: 15541309
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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease.
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Neuron. 2004
PubMed ID: 15541308
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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Genome Res. 2004
PubMed ID: 15489334
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Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
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Nat Genet. 2004
PubMed ID: 14702039
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The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.
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PubMed ID: 14691730
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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PubMed ID: 12466851
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Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags.
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A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.
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Identification of cAMP analogue inducible genes in RAW264 macrophages.
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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