CHUK

Summary Top Help

Gene Description:

conserved helix-loop-helix ubiquitous kinase

Synonyms:

NFKBIKA, Fbx24, Chuk1, IKKA, CHUK, Fbxo24, IKBKA, AI256658, IKK-alpha, IKK1, Ikka, Chuk, TCF16

Orthologs:

Human CHUK (protein-coding), Mouse Chuk (protein-coding), Rat Chuk (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 2

Linkage Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm9	Rat	chr1:247322146..266002939	18.68	162
Klotting Iddm5r	Rat	chr1:247322146..266002939	18.68	162	1 Suggestive for backcross, 2 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr10:101948055..101989376 (41.32 kb) View in Genome Browser

(Mouse) NCBIM37 - chr19:44147824..44181970 (34.15 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:249122845..249158369 (35.52 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CHUK:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CHUK:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 23

Biocarta: 19

Reactome: 12

NCI-Nature Pathway Interaction Database: 18

Gene Ontology: 45

Nucleotide binding	GO:0000166
Morphogenesis of an epithelial sheet	GO:0002011
Toll-like receptor signaling pathway	GO:0002224
MyD88-dependent toll-like receptor signaling pathway	GO:0002755
MyD88-independent toll-like receptor signaling pathway	GO:0002756
Protein kinase activity	GO:0004672
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Cytosol	GO:0005829
Protein phosphorylation	GO:0006468
Inflammatory response	GO:0006954
Immune response	GO:0006955
Epidermal growth factor receptor signaling pathway	GO:0007173
I-kappaB kinase/NF-kappaB cascade	GO:0007249
I-kappaB phosphorylation	GO:0007252
Lactation	GO:0007595
Toll signaling pathway	GO:0008063
IkappaB kinase activity	GO:0008384
IkappaB kinase complex	GO:0008385
Fibroblast growth factor receptor signaling pathway	GO:0008543
Response to virus	GO:0009615
Anatomical structure morphogenesis	GO:0009653
Internal side of plasma membrane	GO:0009898
Osteoclast differentiation	GO:0030316
Mammary gland epithelial cell proliferation	GO:0033598
Toll-like receptor 1 signaling pathway	GO:0034130
Toll-like receptor 2 signaling pathway	GO:0034134
Toll-like receptor 3 signaling pathway	GO:0034138
Toll-like receptor 4 signaling pathway	GO:0034142
CD40 receptor complex	GO:0035631
TRIF-dependent toll-like receptor signaling pathway	GO:0035666
Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:0035872
Odontogenesis of dentin-containing tooth	GO:0042475
Positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043123
Intracellular membrane-bounded organelle	GO:0043231
Innate immune response	GO:0045087
Nerve growth factor receptor signaling pathway	GO:0048011
Phosphatidylinositol-mediated signaling	GO:0048015
T cell receptor signaling pathway	GO:0050852
Positive regulation of NF-kappaB transcription factor activity	GO:0051092
Mammary gland alveolus development	GO:0060749
Nucleotide-binding oligomerization domain containing signaling pathway	GO:0070423

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 419

Escape from transcriptional shutoff during poliovirus infection: NF-κB-responsive genes IκBa and A20.
Doukas T, Sarnow P
J Virol. 2011
PubMed ID: 21795344
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Li S, Wang L, Berman M, Kong YY, Dorf ME
Immunity. 2011
PubMed ID: 21903422
A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.
Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J, Baud V
J Biol Chem. 2011
PubMed ID: 21784860
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW
Nat Immunol. 2011
PubMed ID: 21765415
IκB kinase-driven nuclear factor-κB activation in patients with asthma and chronic obstructive pulmonary disease.
Gagliardo R, Chanez P, Profita M, Bonanno A, Albano GD, Montalbano AM, Pompeo F, Gagliardo C, Merendino AM, Gjomarkaj M
J Allergy Clin Immunol. 2011
PubMed ID: 21571356
Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
Yong Y, Choi SW, Choi HJ, Nam HW, Kim JA, Jeong DU, Kim DY, Kim YS, Kim DW
Mol Cell Biol. 2011
PubMed ID: 21606193
TRIM40 promotes neddylation of IKKγ and is downregulated in gastrointestinal cancers.
Noguchi K, Okumura F, Takahashi N, Kataoka A, Kamiyama T, Todo S, Hatakeyama S
Carcinogenesis. 2011
PubMed ID: 21474709
NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK.
Xia X, Cui J, Wang HY, Zhu L, Matsueda S, Wang Q, Yang X, Hong J, Songyang Z, Chen ZJ, Wang RF
Immunity. 2011
PubMed ID: 21703539
Nuclear factor-κB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1α independent manner.
Yeramian A, Santacana M, Sorolla A, Llobet D, Encinas M, Velasco A, Bahi N, Eritja N, Domingo M, Oliva E, Dolcet X, Matias-Guiu X
Lab Invest. 2011
PubMed ID: 21537326
Blocking IKKα expression inhibits prostate cancer invasiveness.
Mahato R, Qin B, Cheng K
Pharm Res. 2011
PubMed ID: 21191633
Transcriptional regulation of the Th17 immune response by IKK(alpha).
Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH
J Exp Med. 2011
PubMed ID: 21402739
IKK1 control of epidermal differentiation is modulated by notch signaling.
Xin Y, Lu Q, Li Q
Am J Pathol. 2011
PubMed ID: 21435444
A herpesvirus virulence factor inhibits dendritic cell maturation through protein phosphatase 1 and Ikappa B kinase.
Jin H, Yan Z, Ma Y, Cao Y, He B
J Virol. 2011
PubMed ID: 21248029
The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK.
Neely RJ, Brose MS, Gray CM, McCorkell KA, Leibowitz JM, Ma C, Rothstein JL, May MJ
Oncogene. 2011
PubMed ID: 20818435
IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity.
Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ
J Neurosci. 2011
PubMed ID: 21209217
NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs.
Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I
PLoS One. 2011
PubMed ID: 21887257
Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors.
Alameda JP, Moreno-Maldonado R, Fernández-Aceñero MJ, Navarro M, Page A, Jorcano JL, Bravo A, Ramírez Á, Casanova ML
PLoS One. 2011
PubMed ID: 21755017
IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.
Wu L, Shao L, An N, Wang J, Pazhanisamy S, Feng W, Hauer-Jensen M, Miyamoto S, Zhou D
PLoS One. 2011
PubMed ID: 21490922
BAG3 is required for IKKα nuclear translocation and emergence of castration resistant prostate cancer.
Ammirante M, De Laurenzi V, Graziano V, Turco MC, Rosati A
Cell Death Dis. 2011
PubMed ID: 21451574
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers.
Singh R, Bullard J, Kalra M, Assefa S, Kaul AK, Vonfeldt K, Strom SC, Conrad RS, Sharp HL, Kaul R
Clin Immunol. 2011
PubMed ID: 20940109
IKK(α) controls canonical TGF(ß)-SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in panc1 cells.
Brandl M, Seidler B, Haller F, Adamski J, Schmid RM, Saur D, Schneider G
J Cell Sci. 2010
PubMed ID: 21081648
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.
LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE
Dev Cell. 2010
PubMed ID: 21093383
Induction of ΔNp63 by the newly identified keratinocyte-specific transforming growth factor β Signaling Pathway with Smad2 and IκB Kinase α in squamous cell carcinoma.
Fukunishi N, Katoh I, Tomimori Y, Tsukinoki K, Hata R, Nakao A, Ikawa Y, Kurata S
Neoplasia. 2010
PubMed ID: 21170261
Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH).
Devries IL, Hampton-Smith RJ, Mulvihill MM, Alverdi V, Peet DJ, Komives EA
FEBS Lett. 2010
PubMed ID: 21056038
IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.
Chapuis N, Park S, Leotoing L, Tamburini J, Verdier F, Bardet V, Green AS, Willems L, Agou F, Ifrah N, Dreyfus F, Bismuth G, Baud V, Lacombe C, Mayeux P, Bouscary D
Blood. 2010
PubMed ID: 20671123
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM
Nature. 2010
PubMed ID: 20881962
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation.
Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, Iribe M, Goto T, Komai M
J Nutr Biochem. 2010
PubMed ID: 20149620
Mutant CHUK and severe fetal encasement malformation.
Lahtela J, Nousiainen HO, Stefanovic V, Tallila J, Viskari H, Karikoski R, Gentile M, Saloranta C, Varilo T, Salonen R, Kestilä M
N Engl J Med. 2010
PubMed ID: 20961246
ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
Wu ZH, Wong ET, Shi Y, Niu J, Chen Z, Miyamoto S, Tergaonkar V
Mol Cell. 2010
PubMed ID: 20932476
The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}.
Gouin E, Adib-Conquy M, Balestrino D, Nahori MA, Villiers V, Colland F, Dramsi S, Dussurget O, Cossart P
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20855622
NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells.
Cummins EP, Oliver KM, Lenihan CR, Fitzpatrick SF, Bruning U, Scholz CC, Slattery C, Leonard MO, McLoughlin P, Taylor CT
J Immunol. 2010
PubMed ID: 20817876
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation.
Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, Liu ZG
Nat Immunol. 2010
PubMed ID: 20711193
The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease.
Rotman Y, Koh C, Zmuda JM, Kleiner DE, Liang TJ, NASH CRN
Hepatology. 2010
PubMed ID: 20684021
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V
Nat Cell Biol. 2010
PubMed ID: 20622870
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation.
Chung S, Sundar IK, Yao H, Ho YS, Rahman I
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 20472709
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways.
Potter C, Cordell HJ, Barton A, Daly AK, Hyrich KL, Mann DA, Morgan AW, Wilson AG, and the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Isaacs JD
Ann Rheum Dis. 2010
PubMed ID: 20448286
Regulation of NF-kappaB responses by epigenetic suppression of IkappaBalpha expression in HCT116 intestinal epithelial cells.
O'Gorman A, Colleran A, Ryan A, Mann J, Egan LJ
Am J Physiol Gastrointest Liver Physiol. 2010
PubMed ID: 20378831
Oxidative stress increases phosphorylation of IkappaB kinase-alpha by enhancing NF-kappaB-inducing kinase after transient focal cerebral ischemia.
Song YS, Kim MS, Kim HA, Jung BI, Yang J, Narasimhan P, Kim GS, Jung JE, Park EH, Chan PH
J Cereb Blood Flow Metab. 2010
PubMed ID: 20125184
Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.
Coles AH, Gannon H, Cerny A, Kurt-Jones E, Jones SN
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20534538
Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex.
Gambaryan S, Kobsar A, Rukoyatkina N, Herterich S, Geiger J, Smolenski A, Lohmann SM, Walter U
J Biol Chem. 2010
PubMed ID: 20356841
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
Crosstalk between the NF-kappaB activating IKK-complex and the CSN signalosome.
Orel L, Neumeier H, Hochrainer K, Binder BR, Schmid JA
J Cell Mol Med. 2010
PubMed ID: 19656241
Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ
Breast Cancer Res Treat. 2010
PubMed ID: 20508983
Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.
Jeon KI, Xu X, Aizawa T, Lim JH, Jono H, Kwon DS, Abe J, Berk BC, Li JD, Yan C
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20448200
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
J Infect Dis. 2010
PubMed ID: 20331378
Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis.
Xia X, Park E, Liu B, Willette-Brown J, Gong W, Wang J, Mitchell D, Fischer SM, Hu Y
Am J Pathol. 2010
PubMed ID: 20304950
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways.
Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ, Wang RF
Cell. 2010
PubMed ID: 20434986
Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected].
Penzo M, Molteni R, Suda T, Samaniego S, Raucci A, Habiel DM, Miller F, Jiang HP, Li J, Pardi R, Palumbo R, Olivotto E, Kew RR, Bianchi ME, Marcu KB
J Immunol. 2010
PubMed ID: 20231695
NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein.
Srivastava R, Burbach BJ, Shimizu Y
J Biol Chem. 2010
PubMed ID: 20164171
Biological Pathway-Based Genome-Wide Association Analysis Identified the Vasoactive Intestinal Peptide (VIP) Pathway Important for Obesity.
Liu YJ, Guo YF, Zhang LS, Pei YF, Yu N, Yu P, Papasian CJ, Deng HW
Obesity (Silver Spring). 2010
PubMed ID: 20379146
Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.
Hoshino K, Sasaki I, Sugiyama T, Yano T, Yamazaki C, Yasui T, Kikutani H, Kaisho T
J Immunol. 2010
PubMed ID: 20200270
Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Int J Mol Med. 2010
PubMed ID: 20198315
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer.
Jiang R, Xia Y, Li J, Deng L, Zhao L, Shi J, Wang X, Sun B
Int J Cancer. 2010
PubMed ID: 19728335
RKIP inhibits NF-kappaB in cancer cells by regulating upstream signaling components of the IkappaB kinase complex.
Tang H, Park S, Sun SC, Trumbly R, Ren G, Tsung E, Yeung KC
FEBS Lett. 2010
PubMed ID: 20043910
A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression.
Song L, Dong W, Gao M, Li J, Hu M, Guo N, Huang C
Biochim Biophys Acta. 2010
PubMed ID: 20080131
NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.
Kim HB, Evans I, Smallwood R, Holcombe M, Qwarnstrom EE
Biosystems. 2010
PubMed ID: 19909783
Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway.
Zhang J, Lei T, Chen X, Peng Y, Long H, Zhou L, Huang J, Chen Z, Long Q, Yang Z
Inflammation. 2010
PubMed ID: 19774455
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.
Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, Sonenshein G, Osborne BA, Miele L
Oncogene. 2010
PubMed ID: 19838210
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
Hostager BS, Fox DK, Whitten D, Wilkerson CG, Eipper BA, Francone VP, Rothman PB, Colgan JD
PLoS One. 2010
PubMed ID: 20614026
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.
Razani B, Zarnegar B, Ytterberg AJ, Shiba T, Dempsey PW, Ware CF, Loo JA, Cheng G
Sci Signal. 2010
PubMed ID: 20501937
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.
Chun JN, Choi B, Lee KW, Lee DJ, Kang DH, Lee JY, Song IS, Kim HI, Lee SH, Kim HS, Lee NK, Lee SY, Lee KJ, Kim J, Kang SW
PLoS One. 2010
PubMed ID: 20351780
IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.
Adli M, Merkhofer E, Cogswell P, Baldwin AS
PLoS One. 2010
PubMed ID: 20195534
Expanding the substantial interactome of NEMO using protein microarrays.
Fenner BJ, Scannell M, Prehn JH
PLoS One. 2010
PubMed ID: 20098747
Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.
Valentine R, Dawson CW, Hu C, Shah KM, Owen TJ, Date KL, Maia SP, Shao J, Arrand JR, Young LS, O'Neil JD
Mol Cancer. 2010
PubMed ID: 20051109
Strain-dependent activation of NF-kappaB in the airway epithelium and its role in allergic airway inflammation.
Alcorn JF, Ckless K, Brown AL, Guala AS, Kolls JK, Poynter ME, Irvin CG, van der Vliet A, Janssen-Heininger YM
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 19897746
B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation.
Bhattacharyya S, Borthakur A, Tyagi S, Gill R, Chen ML, Dudeja PK, Tobacman JK
J Biol Chem. 2010
PubMed ID: 19897484
Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y
Am J Hypertens. 2010
PubMed ID: 19851296
IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
Balkhi MY, Fitzgerald KA, Pitha PM
Cell Signal. 2010
PubMed ID: 19786094
RIP4 regulates epidermal differentiation and cutaneous inflammation.
Rountree RB, Willis CR, Dinh H, Blumberg H, Bailey K, Dean C, Peschon JJ, Holland PM
J Invest Dermatol. 2010
PubMed ID: 19626033
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS
J Cell Biol. 2009
PubMed ID: 20026656
Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction.
Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, Feltham R, Vince J, Warnken U, Wenger T, Koschny R, Komander D, Silke J, Walczak H
Mol Cell. 2009
PubMed ID: 20005846
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.
Stanghellini I, Falco G, Lee SL, Monti M, Ko MS
Gene Expr Patterns. 2009
PubMed ID: 19703589
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
De-ubiquitylation is the most critical step in the ubiquitin-mediated homeostatic control of the NF-kappaB/IKK basal activity.
Palma L, Crinelli R, Bianchi M, Magnani M
Mol Cell Biochem. 2009
PubMed ID: 19421711
Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation.
Liu J, Zhao Y, Eilers M, Lin A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19815509
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.
Xu M, Skaug B, Zeng W, Chen ZJ
Mol Cell. 2009
PubMed ID: 19854138
Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases in the cellular expression of p65 and are not solely produced by increases in IkappaB-alpha kinase activity.
Singh R, Millman G, Turin E, Polisiakeiwicz L, Lee B, Gatti F, Berge J, Smith E, Rutter J, Sumski C, Winders WT, Samadi A, Carlson CG
J Neurol Sci. 2009
PubMed ID: 19631348
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M
Cancer Cell. 2009
PubMed ID: 19800575
NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.
Solt LA, Madge LA, May MJ
J Biol Chem. 2009
PubMed ID: 19666475
Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2(-/y) mice.
Pawlowski TL, Heringer-Walther S, Cheng CH, Archie JG, Chen CF, Walther T, Srivastava AK
Genomics. 2009
PubMed ID: 19501643
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
Increased IkappaB alpha expression is essential for the tolerogenic property of TGF-beta-exposed APCs.
Ghafoori P, Yoshimura T, Turpie B, Masli S
FASEB J. 2009
PubMed ID: 19237504
Inhibition of osteoblastic bone formation by nuclear factor-kappaB.
Chang J, Wang Z, Tang E, Fan Z, McCauley L, Franceschi R, Guan K, Krebsbach PH, Wang CY
Nat Med. 2009
PubMed ID: 19448637
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K
Nat Immunol. 2009
PubMed ID: 19412180
High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle.
Yaspelkis BB, Kvasha IA, Figueroa TY
Am J Physiol Regul Integr Comp Physiol. 2009
PubMed ID: 19386987
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.
Hideshima T, Chauhan D, Kiziltepe T, Ikeda H, Okawa Y, Podar K, Raje N, Protopopov A, Munshi NC, Richardson PG, Carrasco RD, Anderson KC
Blood. 2009
PubMed ID: 19270264
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
Pathogen recognition in the innate immune response.
Kumar H, Kawai T, Akira S
Biochem J. 2009
PubMed ID: 19382893
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
[Influence of inhibitory KappaB protein kinase alpha and gamma genes silencing induced by RNA interference on nuclear factor-KappaB signal pathway]
Chen HL, Li HL, Zhang GX, Li H, Liu J, He XM
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009
PubMed ID: 19278579
Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.
Chang ET, Birmann BM, Kasperzyk JL, Conti DV, Kraft P, Ambinder RF, Zheng T, Mueller NE
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19223558
Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells.
Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB
Blood. 2009
PubMed ID: 18952893
Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction.
Bode KA, Schmitz F, Vargas L, Heeg K, Dalpke AH
J Immunol. 2009
PubMed ID: 19201871
SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.
Tai DJ, Su CC, Ma YL, Lee EH
J Biol Chem. 2009
PubMed ID: 19088076
Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB.
Wang C, Chen T, Zhang N, Yang M, Li B, Lü X, Cao X, Ling C
J Biol Chem. 2009
PubMed ID: 19074436
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K
Nat Cell Biol. 2009
PubMed ID: 19136968
Critical role of IkappaB kinase alpha in embryonic skin development and skin carcinogenesis.
Zhu F, Park E, Liu B, Xia X, Fischer SM, Hu Y
Histol Histopathol. 2009
PubMed ID: 19085841
The IkappaB kinases IKKalpha and IKKbeta are necessary and sufficient for skeletal muscle atrophy.
Van Gammeren D, Damrauer JS, Jackman RW, Kandarian SC
FASEB J. 2009
PubMed ID: 18827022
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.
Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18688039
PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.
Li S, Wang L, Dorf ME
Mol Cell. 2009
PubMed ID: 19150425
Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.
Melnick M, Phair RD, Lapidot SA, Jaskoll T
BMC Dev Biol. 2009
PubMed ID: 19500387
IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.
Khoshnan A, Ko J, Tescu S, Brundin P, Patterson PH
PLoS One. 2009
PubMed ID: 19488402
IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias.
Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A
J Invest Dermatol. 2009
PubMed ID: 18633439
Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.
Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W, Zhao H, Yu X, Dang L, Staudt LM
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19104039
Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway.
Chen PH, Yang CR
J Immunol. 2008
PubMed ID: 19050262
Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.
Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR
Aging Cell. 2008
PubMed ID: 18782346
Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival.
Win HY, Acevedo-Duncan M
Cancer Lett. 2008
PubMed ID: 18571841
Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.
Cerhan JR, Liu-Mares W, Fredericksen ZS, Novak AJ, Cunningham JM, Kay NE, Dogan A, Liebow M, Wang AH, Call TG, Habermann TM, Ansell SM, Slager SL
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18990758
CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia.
Lim JH, Ha UH, Woo CH, Xu H, Li JD
Cell Microbiol. 2008
PubMed ID: 18643924
IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer.
Descargues P, Sil AK, Karin M
EMBO J. 2008
PubMed ID: 18818691
Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.
Song LL, Peng Y, Yun J, Rizzo P, Chaturvedi V, Weijzen S, Kast WM, Stone PJ, Santos L, Loredo A, Lendahl U, Sonenshein G, Osborne B, Qin JZ, Pannuti A, Nickoloff BJ, Miele L
Oncogene. 2008
PubMed ID: 18560356
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
Yuan X, Waterworth D, Perry JR, Lim N, Song K, Chambers JC, Zhang W, Vollenweider P, Stirnadel H, Johnson T, Bergmann S, Beckmann ND, Li Y, Ferrucci L, Melzer D, Hernandez D, Singleton A, Scott J, Elliott P, Waeber G, Cardon L, Frayling TM, Kooner JS, Mooser V
Am J Hum Genet. 2008
PubMed ID: 18940312
Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer.
Wilson W, Baldwin AS
Cancer Res. 2008
PubMed ID: 18829575
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.
Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR, Pasparakis M
EMBO Rep. 2008
PubMed ID: 18704119
IKK/NF-kappaB signaling pathway inhibits cell-cycle progression by a novel Rb-independent suppression system for E2F transcription factors.
Araki K, Kawauchi K, Tanaka N
Oncogene. 2008
PubMed ID: 18542057
IKKalpha is required to maintain skin homeostasis and prevent skin cancer.
Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y
Cancer Cell. 2008
PubMed ID: 18772111
Osteoblasts-derived BMP-2 enhances the motility of prostate cancer cells via activation of integrins.
Lai TH, Fong YC, Fu WM, Yang RS, Tang CH
Prostate. 2008
PubMed ID: 18512729
Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model.
Siddiqui IA, Shukla Y, Adhami VM, Sarfaraz S, Asim M, Hafeez BB, Mukhtar H
Pharm Res. 2008
PubMed ID: 18317887
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18713867
Respiratory syncytial virus induces RelA release from cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I{middle dot}NF- kappa B-inducing kinase signaling pathway.
Liu P, Li K, Garofalo RP, Brasier AR
J Biol Chem. 2008
PubMed ID: 18550535
Essential role for epidermal growth factor receptor in glutamate receptor signaling to NF-kappaB.
Sitcheran R, Comb WC, Cogswell PC, Baldwin AS
Mol Cell Biol. 2008
PubMed ID: 18541671
siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.
Austin RL, Rune A, Bouzakri K, Zierath JR, Krook A
Diabetes. 2008
PubMed ID: 18443205
IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.
Luedde T, Heinrichsdorff J, de Lorenzi R, De Vos R, Roskams T, Pasparakis M
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18606991
IkBalpha Promoter Polymorphisms in Patients with Primary Sjögren's Syndrome.
Ou TT, Lin CH, Lin YC, Li RN, Tsai WC, Liu HW, Yen JH
J Clin Immunol. 2008
PubMed ID: 18600435
IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas.
Moreno-Maldonado R, Ramírez A, Navarro M, Fernández-Aceñero MJ, Villanueva C, Page A, Jorcano JL, Bravo A, Llanos Casanova M
Cell Cycle. 2008
PubMed ID: 18604171
Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB
Cancer Res. 2008
PubMed ID: 18593939
Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent manner.
Song L, Li J, Hu M, Huang C
Exp Cell Res. 2008
PubMed ID: 18508047
Beta2-adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappaB activation through beta-arrestin 2.
Kizaki T, Izawa T, Sakurai T, Haga S, Taniguchi N, Tajiri H, Watanabe K, Day NK, Toba K, Ohno H
Immunology. 2008
PubMed ID: 18194271
Dynein light chain LC8 negatively regulates NF-kappa B through the redox-dependent interaction with Ikappa Balpha.
Jung Y, Kim H, Min SH, Rhee SG, Jeong W
J Biol Chem. 2008
PubMed ID: 18579519
Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt.
Dan HC, Baldwin AS
J Immunol. 2008
PubMed ID: 18490760
IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung.
Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I
Am J Respir Cell Mol Biol. 2008
PubMed ID: 18239189
[P53-independent apoptosis through a novel ATM/IKK-alpha/p73-mediated apoptotic pathway]
Ozaki T, Nakagawara A
Seikagaku. 2008
PubMed ID: 18575226
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.
Rushe M, Silvian L, Bixler S, Chen LL, Cheung A, Bowes S, Cuervo H, Berkowitz S, Zheng T, Guckian K, Pellegrini M, Lugovskoy A
Structure. 2008
PubMed ID: 18462684
p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.
Kawauchi K, Araki K, Tobiume K, Tanaka N
Nat Cell Biol. 2008
PubMed ID: 18391940
Cystic fibrosis transmembrane conductance regulator controls lung proteasomal degradation and nuclear factor-kappaB activity in conditions of oxidative stress.
Boncoeur E, Roque T, Bonvin E, Saint-Criq V, Bonora M, Clement A, Tabary O, Henrion-Caude A, Jacquot J
Am J Pathol. 2008
PubMed ID: 18372427
Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1.
Li HY, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, Li WH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM
Nat Immunol. 2008
PubMed ID: 18362886
Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.
Pantano C, Ather JL, Alcorn JF, Poynter ME, Brown AL, Guala AS, Beuschel SL, Allen GB, Whittaker LA, Bevelander M, Irvin CG, Janssen-Heininger YM
Am J Respir Crit Care Med. 2008
PubMed ID: 18263801
Tumour maintenance is mediated by eNOS.
Lim KH, Ancrile BB, Kashatus DF, Counter CM
Nature. 2008
PubMed ID: 18344980
New role of IKK alpha/beta phosphorylated I kappa B alpha in axon outgrowth and axon initial segment development.
Sanchez-Ponce D, Tapia M, Muñoz A, Garrido JJ
Mol Cell Neurosci. 2008
PubMed ID: 18321726
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.
Wang RP, Zhang M, Li Y, Diao FC, Chen D, Zhai Z, Shu HB
Mol Immunol. 2008
PubMed ID: 18068231
Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome.
Kfoury Y, Nasr R, Favre-Bonvin A, El-Sabban M, Renault N, Giron ML, Setterblad N, Hajj HE, Chiari E, Mikati AG, Hermine O, Saib A, de Thé H, Pique C, Bazarbachi A
Oncogene. 2008
PubMed ID: 17891179
Mutations in the zinc finger domain of IKK gamma block the activation of NF-kappa B and the induction of IL-2 in stimulated T lymphocytes.
Shifera AS, Horwitz MS
Mol Immunol. 2008
PubMed ID: 18207244
Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.
Windheim M, Stafford M, Peggie M, Cohen P
Mol Cell Biol. 2008
PubMed ID: 18180283
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis.
Bakkar N, Wang J, Ladner KJ, Wang H, Dahlman JM, Carathers M, Acharyya S, Rudnicki MA, Hollenbach AD, Guttridge DC
J Cell Biol. 2008
PubMed ID: 18299349
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation.
Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18268325
Shared principles in NF-kappaB signaling.
Hayden MS, Ghosh S
Cell. 2008
PubMed ID: 18267068
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Núñez G, Inohara N
EMBO J. 2008
PubMed ID: 18079694
The IkappaB kinase complex: master regulator of NF-kappaB signaling.
Solt LA, May MJ
Immunol Res. 2008
PubMed ID: 18626576
Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.
Olivotto E, Borzi RM, Vitellozzi R, Pagani S, Facchini A, Battistelli M, Penzo M, Li X, Flamigni F, Li J, Falcieri E, Facchini A, Marcu KB
Arthritis Rheum. 2008
PubMed ID: 18163512
IkappaBalpha Promoter Polymorphisms in Patients with Systemic Lupus Erythematosus.
Lin CH, Wang SC, Ou TT, Li RN, Tsai WC, Liu HW, Yen JH
J Clin Immunol. 2007
PubMed ID: 18071880
A cell cycle regulatory network controlling NF-kappaB subunit activity and function.
Barré B, Perkins ND
EMBO J. 2007
PubMed ID: 17962807
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
Yamaguchi T, Kimura J, Miki Y, Yoshida K
J Biol Chem. 2007
PubMed ID: 17897950
Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.
Ghosh A, Roy A, Liu X, Kordower JH, Mufson EJ, Hartley DM, Ghosh S, Mosley RL, Gendelman HE, Pahan K
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18000063
Modification of IkappaBalpha by taurine bromamine inhibits tumor necrosis factor alpha-induced NF-kappaB activation.
Tokunaga S, Kanayama A, Miyamoto Y
Inflamm Res. 2007
PubMed ID: 18224289
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species.
Kumar A, Wu H, Collier-Hyams LS, Hansen JM, Li T, Yamoah K, Pan ZQ, Jones DP, Neish AS
EMBO J. 2007
PubMed ID: 17914462
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A
J Biol Chem. 2007
PubMed ID: 17823124
IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells.
Cao Y, Luo JL, Karin M
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17890319
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Park E, Zhu F, Liu B, Xia X, Shen J, Bustos T, Fischer SM, Hu Y
Cancer Res. 2007
PubMed ID: 17909021
FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly.
Park MY, Moon JH, Lee KS, Choi HI, Chung J, Hong HJ, Kim E
J Biol Chem. 2007
PubMed ID: 17684021
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
Epigenetic inactivation of IkappaB Kinase-alpha in oral carcinomas and tumor progression.
Maeda G, Chiba T, Kawashiri S, Satoh T, Imai K
Clin Cancer Res. 2007
PubMed ID: 17785555
Kaposi's sarcoma-associated herpesvirus (KSHV) oncoprotein K13 bypasses TRAFs and directly interacts with the IkappaB kinase complex to selectively activate NF-kappaB without JNK activation.
Matta H, Mazzacurati L, Schamus S, Yang T, Sun Q, Chaudhary PM
J Biol Chem. 2007
PubMed ID: 17597077
IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing.
Zhu F, Xia X, Liu B, Shen J, Hu Y, Person M, Hu Y
Mol Cell. 2007
PubMed ID: 17643371
Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.
Gloire G, Horion J, El Mjiyad N, Bex F, Chariot A, Dejardin E, Piette J
J Biol Chem. 2007
PubMed ID: 17537731
A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity.
Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, Xia Y
J Biol Chem. 2007
PubMed ID: 17526490
Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat.
Fillmann H, Kretzmann NA, San-Miguel B, Llesuy S, Marroni N, González-Gallego J, Tuñón MJ
Toxicology. 2007
PubMed ID: 17543437
Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha.
Dan HC, Adli M, Baldwin AS
Cancer Res. 2007
PubMed ID: 17616684
Cytotoxic necrotizing factor 1 prevents apoptosis via the Akt/IkappaB kinase pathway: role of nuclear factor-kappaB and Bcl-2.
Miraglia AG, Travaglione S, Meschini S, Falzano L, Matarrese P, Quaranta MG, Viora M, Fiorentini C, Fabbri A
Mol Biol Cell. 2007
PubMed ID: 17507655
Vacuolating cytotoxin in Helicobacter pylori water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-kappaB activation.
Kim JM, Kim JS, Lee JY, Kim YJ, Youn HJ, Kim IY, Chee YJ, Oh YK, Kim N, Jung HC, Song IS
Infect Immun. 2007
PubMed ID: 17452475
Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis.
Furuya K, Ozaki T, Hanamoto T, Hosoda M, Hayashi S, Barker PA, Takano K, Matsumoto M, Nakagawara A
J Biol Chem. 2007
PubMed ID: 17452332
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
Pandey MK, Sandur SK, Sung B, Sethi G, Kunnumakkara AB, Aggarwal BB
J Biol Chem. 2007
PubMed ID: 17439942
Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
Liu B, Yang Y, Chernishof V, Loo RR, Jang H, Tahk S, Yang R, Mink S, Shultz D, Bellone CJ, Loo JA, Shuai K
Cell. 2007
PubMed ID: 17540171
Mouse models of psoriasis.
Gudjonsson JE, Johnston A, Dyson M, Valdimarsson H, Elder JT
J Invest Dermatol. 2007
PubMed ID: 17429444
Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity.
Bashan N, Dorfman K, Tarnovscki T, Harman-Boehm I, Liberty IF, Blüher M, Ovadia S, Maymon-Zilberstein T, Potashnik R, Stumvoll M, Avinoach E, Rudich A
Endocrinology. 2007
PubMed ID: 17317777
Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.
Saadane A, Masters S, DiDonato J, Li J, Berger M
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17272824
NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.
Fontan E, Traincard F, Levy SG, Yamaoka S, Véron M, Agou F
FEBS J. 2007
PubMed ID: 17419723
Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK.
Wu X, Sun SC
EMBO Rep. 2007
PubMed ID: 17363973
Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB.
Huang WC, Ju TK, Hung MC, Chen CC
Mol Cell. 2007
PubMed ID: 17434128
Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals.
Mills DM, Bonizzi G, Karin M, Rickert RC
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17404218
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin.
Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M
Nature. 2007
PubMed ID: 17377533
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger J, Lin X
EMBO J. 2007
PubMed ID: 17363905
Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.
Gareus R, Huth M, Breiden B, Nenci A, Rösch N, Haase I, Bloch W, Sandhoff K, Pasparakis M
Nat Cell Biol. 2007
PubMed ID: 17351639
Epithelial NEMO links innate immunity to chronic intestinal inflammation.
Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M
Nature. 2007
PubMed ID: 17361131
Structural studies on 24P-IkappaBalpha peptide derived from a human IkappaB-alpha protein related to the inhibition of the activity of the transcription factor NF-kappaB.
Pons J, Evrard-Todeschi N, Bertho G, Gharbi-Benarous J, Sonois V, Benarous R, Girault JP
Biochemistry. 2007
PubMed ID: 17319651
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
p14ARF interacts with N-Myc and inhibits its transcriptional activity.
Amente S, Gargano B, Diolaiti D, Della Valle G, Lania L, Majello B
FEBS Lett. 2007
PubMed ID: 17289033
In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the releas
Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, Romeo G, Federico M, Geyer M, Affabris E
J Virol. 2007
PubMed ID: 17182689
p63 induces key target genes required for epidermal morphogenesis.
Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360634
Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase.
Harhaj NS, Sun SC, Harhaj EW
J Biol Chem. 2007
PubMed ID: 17145747
Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level.
Roué G, Pérez-Galán P, López-Guerra M, Villamor N, Campo E, Colomer D
J Immunol. 2007
PubMed ID: 17237443
High concentration of antioxidants N-acetylcysteine and mitoquinone-Q induces intercellular adhesion molecule 1 and oxidative stress by increasing intracellular glutathione.
Mukherjee TK, Mishra AK, Mukhopadhyay S, Hoidal JR
J Immunol. 2007
PubMed ID: 17237434
A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae.
Ha U, Lim JH, Jono H, Koga T, Srivastava A, Malley R, Pagès G, Pouysségur J, Li JD
J Immunol. 2007
PubMed ID: 17237423
Thymus medulla formation and central tolerance are restored in IKKalpha-/- mice that express an IKKalpha transgene in keratin 5+ thymic epithelial cells.
Lomada D, Liu B, Coghlan L, Hu Y, Richie ER
J Immunol. 2007
PubMed ID: 17202344
Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis.
Zaragoza C, Saura M, Padalko EY, Lopez-Rivera E, Lizarbe TR, Lamas S, Lowenstein CJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17138672
Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling.
Mittal R, Peak-Chew SY, McMahon HT
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17116858
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas.
Liu B, Park E, Zhu F, Bustos T, Liu J, Shen J, Fischer SM, Hu Y
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17079494
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.
Richardson RJ, Dixon J, Malhotra S, Hardman MJ, Knowles L, Boot-Handford RP, Shore P, Whitmarsh A, Dixon MJ
Nat Genet. 2006
PubMed ID: 17041603
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6).
Ingraham CR, Kinoshita A, Kondo S, Yang B, Sajan S, Trout KJ, Malik MI, Dunnwald M, Goudy SL, Lovett M, Murray JC, Schutte BC
Nat Genet. 2006
PubMed ID: 17041601
Regulation and function of IKK and IKK-related kinases.
Häcker H, Karin M
Sci STKE. 2006
PubMed ID: 17047224
IKKalpha regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation.
Prajapati S, Tu Z, Yamamoto Y, Gaynor RB
Cell Cycle. 2006
PubMed ID: 17102620
Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos.
Falco G, Stanghellini I, Ko MS
Reprod Biomed Online. 2006
PubMed ID: 16984773
Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.
Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M
Immunity. 2006
PubMed ID: 16973390
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.
Schneider G, Saur D, Siveke JT, Fritsch R, Greten FR, Schmid RM
EMBO J. 2006
PubMed ID: 16902410
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines.
Nakagawa Y, Akao Y
Exp Cell Res. 2006
PubMed ID: 16733051
beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870.
Liang C, Zhang M, Sun SC
Cell Signal. 2006
PubMed ID: 16303288
Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation.
Nasr R, Chiari E, El-Sabban M, Mahieux R, Kfoury Y, Abdulhay M, Yazbeck V, Hermine O, de Thé H, Pique C, Bazarbachi A
Blood. 2006
PubMed ID: 16424386
IkappaB is a sensitive target for oxidation by cell-permeable chloramines: inhibition of NF-kappaB activity by glycine chloramine through methionine oxidation.
Midwinter RG, Cheah FC, Moskovitz J, Vissers MC, Winterbourn CC
Biochem J. 2006
PubMed ID: 16405428
IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9.
Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, Hemmi H, Ohara O, Akira S, Kaisho T
Nature. 2006
PubMed ID: 16612387
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.
Kinoshita D, Hirota F, Kaisho T, Kasai M, Izumi K, Bando Y, Mouri Y, Matsushima A, Niki S, Han H, Oshikawa K, Kuroda N, Maegawa M, Irahara M, Takeda K, Akira S, Matsumoto M
J Immunol. 2006
PubMed ID: 16547234
IKK alpha regulates estrogen-induced cell cycle progression by modulating E2F1 expression.
Tu Z, Prajapati S, Park KJ, Kelly NJ, Yamamoto Y, Gaynor RB
J Biol Chem. 2006
PubMed ID: 16407216
Binding of manumycin A inhibits IkappaB kinase beta activity.
Bernier M, Kwon YK, Pandey SK, Zhu TN, Zhao RJ, Maciuk A, He HJ, Decabo R, Kole S
J Biol Chem. 2006
PubMed ID: 16319058
The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1.
Wu L, Nakano H, Wu Z
J Biol Chem. 2006
PubMed ID: 16280329
Interleukin-1beta induction of NFkappaB is partially regulated by H2O2-mediated activation of NFkappaB-inducing kinase.
Li Q, Engelhardt JF
J Biol Chem. 2006
PubMed ID: 16286467
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
Am J Hum Genet. 2006
PubMed ID: 16385451
IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300.
Hoberg JE, Popko AE, Ramsey CS, Mayo MW
Mol Cell Biol. 2006
PubMed ID: 16382138
Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.
Sekine Y, Yumioka T, Yamamoto T, Muromoto R, Imoto S, Sugiyma K, Oritani K, Shimoda K, Minoguchi M, Akira S, Yoshimura A, Matsuda T
J Immunol. 2006
PubMed ID: 16365431
Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase.
Wu L, Iwai M, Li Z, Li JM, Mogi M, Horiuchi M
J Hypertens. 2006
PubMed ID: 16331110
Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation.
Stuhlmeier KM, Pollaschek C
J Biol Chem. 2005
PubMed ID: 16258173
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, Tschopp J
Nature. 2005
PubMed ID: 16177806
Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines.
Levrand S, Pesse B, Feihl F, Waeber B, Pacher P, Rolli J, Schaller MD, Liaudet L
J Biol Chem. 2005
PubMed ID: 16079150
IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation.
Kwak YT, Li R, Becerra CR, Tripathy D, Frenkel EP, Verma UN
J Biol Chem. 2005
PubMed ID: 16103118
Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.
Jung SY, Malovannaya A, Wei J, O'Malley BW, Qin J
Mol Endocrinol. 2005
PubMed ID: 16051665
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.
Schwabe RF, Sakurai H
FASEB J. 2005
PubMed ID: 16046471
Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle.
Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ
Am J Physiol Cell Physiol. 2005
PubMed ID: 15888549
Oxidative stress transiently decreases the IKK complex (IKKalpha, beta, and gamma), an upstream component of NF-kappaB signaling, after transient focal cerebral ischemia in mice.
Song YS, Lee YS, Chan PH
J Cereb Blood Flow Metab. 2005
PubMed ID: 15829915
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators.
Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M
Immunity. 2005
PubMed ID: 16169504
Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).
Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F, Verma IM
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16116086
Constitutive nuclear expression of the I kappa B kinase complex and its activation in human neutrophils.
Ear T, Cloutier A, McDonald PP
J Immunol. 2005
PubMed ID: 16034126
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis.
Maeda S, Kamata H, Luo JL, Leffert H, Karin M
Cell. 2005
PubMed ID: 15989949
Production of matrix metalloproteinase-9 by activated human monocytes involves a phosphatidylinositol-3 kinase/Akt/IKKalpha/NF-kappaB pathway.
Lu Y, Wahl LM
J Leukoc Biol. 2005
PubMed ID: 15800029
Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.
Xu C, Shen G, Chen C, Gélinas C, Kong AN
Oncogene. 2005
PubMed ID: 15856023
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts.
Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S
Oncogene. 2005
PubMed ID: 15782119
Ectoderm-targeted overexpression of the glucocorticoid receptor induces hypohidrotic ectodermal dysplasia.
Cascallana JL, Bravo A, Donet E, Leis H, Lara MF, Paramio JM, Jorcano JL, Pérez P
Endocrinology. 2005
PubMed ID: 15746257
I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.
Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M
J Exp Med. 2005
PubMed ID: 15897281
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.
Lawrence T, Bebien M, Liu GY, Nizet V, Karin M
Nature. 2005
PubMed ID: 15858576
Gene expression profiling in conjunction with physiological rescues of IKKalpha-null cells with wild type or mutant IKKalpha reveals distinct classes of IKKalpha/NF-kappaB-dependent genes.
Massa PE, Li X, Hanidu A, Siamas J, Pariali M, Pareja J, Savitt AG, Catron KM, Li J, Marcu KB
J Biol Chem. 2005
PubMed ID: 15695520
Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide.
Lee JY, Yu BP, Chung HY
Free Radic Res. 2005
PubMed ID: 16028365
A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.
Verkoczy L, Aït-Azzouzene D, Skog P, Märtensson A, Lang J, Duong B, Nemazee D
Immunity. 2005
PubMed ID: 15845455
Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.
Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB
Mol Cell. 2005
PubMed ID: 15808510
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation.
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S
Science. 2005
PubMed ID: 15802604
The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.
Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS
J Biol Chem. 2005
PubMed ID: 15684432
Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.
Qing G, Xiao G
J Biol Chem. 2005
PubMed ID: 15677466
High-throughput mapping of a dynamic signaling network in mammalian cells.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL
Science. 2005
PubMed ID: 15761153
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing.
Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M
Science. 2005
PubMed ID: 15692052
Alpha-interferon and its effects on signal transduction pathways.
Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A
J Cell Physiol. 2005
PubMed ID: 15389589
Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation.
Panopoulos A, Harraz M, Engelhardt JF, Zandi E
J Biol Chem. 2005
PubMed ID: 15550384
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
Cheng H, Cenciarelli C, Nelkin G, Tsan R, Fan D, Cheng-Mayer C, Fidler IJ
Mol Cell Biol. 2005
PubMed ID: 15601829
Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK
Buss H, Dörrie A, Schmitz ML, Hoffmann E, Resch K, Kracht M
J Biol Chem. 2004
PubMed ID: 15489227
Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha.
Chaisson ML, Branstetter DG, Derry JM, Armstrong AP, Tometsko ME, Takeda K, Akira S, Dougall WC
J Biol Chem. 2004
PubMed ID: 15485831
Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively.
Gu L, Zhu N, Findley HW, Woods WG, Zhou M
J Biol Chem. 2004
PubMed ID: 15469934
PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.
Bruey JM, Bruey-Sedano N, Newman R, Chandler S, Stehlik C, Reed JC
J Biol Chem. 2004
PubMed ID: 15456791
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue.
Drayton DL, Bonizzi G, Ying X, Liao S, Karin M, Ruddle NH
J Immunol. 2004
PubMed ID: 15528353
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.
Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M
EMBO J. 2004
PubMed ID: 15470505
SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival.
Hoberg JE, Yeung F, Mayo MW
Mol Cell. 2004
PubMed ID: 15494311
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai MJ, O'Malley BW
Mol Cell. 2004
PubMed ID: 15383283
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation.
Xiao G, Fong A, Sun SC
J Biol Chem. 2004
PubMed ID: 15140882
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.
Krappmann D, Wegener E, Sunami Y, Esen M, Thiel A, Mordmuller B, Scheidereit C
Mol Cell Biol. 2004
PubMed ID: 15226448
beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha.
Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15173580
MD-2: the Toll 'gatekeeper' in endotoxin signalling.
Gangloff M, Gay NJ
Trends Biochem Sci. 2004
PubMed ID: 15276183
The DNA sequence and comparative analysis of human chromosome 10.
Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
Nature. 2004
PubMed ID: 15164054
Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.
Sizemore N, Agarwal A, Das K, Lerner N, Sulak M, Rani S, Ransohoff R, Shultz D, Stark GR
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15148408
Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways.
Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G
Mol Cell. 2004
PubMed ID: 15125834
Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway.
Makino K, Day CP, Wang SC, Li YM, Hung MC
Oncogene. 2004
PubMed ID: 15021910
Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells.
Hironaka N, Mochida K, Mori N, Maeda M, Yamamoto N, Yamaoka S
Neoplasia. 2004
PubMed ID: 15153339
Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65.
O'Mahony AM, Montano M, Van Beneden K, Chen LF, Greene WC
J Biol Chem. 2004
PubMed ID: 14963024
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC
Cell. 2004
PubMed ID: 15084260
IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis.
Sil AK, Maeda S, Sano Y, Roop DR, Karin M
Nature. 2004
PubMed ID: 15071597
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Panta GR, Kaur S, Cavin LG, Cortés ML, Mercurio F, Lothstein L, Sweatman TW, Israel M, Arsura M
Mol Cell Biol. 2004
PubMed ID: 14966265
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein.
Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E
J Biol Chem. 2004
PubMed ID: 14660645
Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates the expression of iNOS through IKK and NF-kappaB activity in LPS-stimulated mouse peritoneal macrophages and RAW 264.7 cells.
Kim Y, Moon JS, Lee KS, Park SY, Cheong J, Kang HS, Lee HY, Kim HD
Biochem Biophys Res Commun. 2004
PubMed ID: 14741691
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
A dual role for Ikk alpha in tooth development.
Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT
Dev Cell. 2004
PubMed ID: 14960276
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G
Nat Cell Biol. 2004
PubMed ID: 14743216
Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity.
Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB
J Biol Chem. 2004
PubMed ID: 14585847
Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation.
Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, Li Q, Guzman JR, Korgaonkar CK, Donner DB
J Biol Chem. 2004
PubMed ID: 14585846
Expression of IKKalpha mRNA in the suprachiasmatic nucleus and circadian rhythms of mice lacking IKKalpha.
Hayashi N, Yasuo S, Ebihara S, Yoshimura T
Brain Res. 2003
PubMed ID: 14642849
Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling.
Iha H, Kibler KV, Yedavalli VR, Peloponese JM, Haller K, Miyazato A, Kasai T, Jeang KT
Oncogene. 2003
PubMed ID: 14654787
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB.
Soond SM, Terry JL, Colbert JD, Riches DW
Mol Cell Biol. 2003
PubMed ID: 14585990
Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha.
Rattan R, Giri S, Singh AK, Singh I
Free Radic Biol Med. 2003
PubMed ID: 14572607
Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA
Exp Cell Res. 2003
PubMed ID: 14499622
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
Sakurai H, Suzuki S, Kawasaki N, Nakano H, Okazaki T, Chino A, Doi T, Saiki I
J Biol Chem. 2003
PubMed ID: 12842894
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
GMCSF activates NF-kappaB via direct interaction of the GMCSF receptor with IkappaB kinase beta.
Ebner K, Bandion A, Binder BR, de Martin R, Schmid JA
Blood. 2003
PubMed ID: 12637324
A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression.
Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS
Nature. 2003
PubMed ID: 12789343
Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.
Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB
Nature. 2003
PubMed ID: 12789342
The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation.
Dunnwald M, Zuberi AR, Stephens K, Le R, Sundberg JP, Fleckman P, Dale BA
Exp Dermatol. 2003
PubMed ID: 12823437
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R
Nat Immunol. 2003
PubMed ID: 12717433
Susceptibility to tuberculosis: a locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs.
Mitsos LM, Cardon LR, Ryan L, LaCourse R, North RJ, Gros P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12740444
Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.
Charalambous MP, Maihöfner C, Bhambra U, Lightfoot T, Gooderham NJ, Colorectal Cancer Study Group
Br J Cancer. 2003
PubMed ID: 12771929
Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression.
Huang WC, Chen JJ, Inoue H, Chen CC
J Immunol. 2003
PubMed ID: 12707358
Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.
Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L
J Histochem Cytochem. 2003
PubMed ID: 12704203
Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.
Tegethoff S, Behlke J, Scheidereit C
Mol Cell Biol. 2003
PubMed ID: 12612076
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway.
Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB
J Mol Biol. 2003
PubMed ID: 12547194
IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.
Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, Hughes J, Hulit J, Sakamaki T, Fu M, Ben-Ze'ev A, Bromberg JF, Lamberti C, Verma U, Gaynor RB, Byers SW, Pestell RG
Mol Biol Cell. 2003
PubMed ID: 12589056
Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation.
Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, Jansen ED, Yull FE, Christman JW, Blackwell TS
J Immunol. 2003
PubMed ID: 12517978
Tumor necrosis factor signaling.
Wajant H, Pfizenmaier K, Scheurich P
Cell Death Differ. 2003
PubMed ID: 12655295
betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben-Neriah Y, Ley SC
Mol Cell Biol. 2003
PubMed ID: 12482991
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J
J Biol Chem. 2002
PubMed ID: 12351658
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.
Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, Mische S, Li J, Marcu KB
J Biol Chem. 2002
PubMed ID: 12221085
Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis.
Munzert G, Kirchner D, Stobbe H, Bergmann L, Schmid RM, Döhner H, Heimpel H
Blood. 2002
PubMed ID: 12411322
Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha.
Rottenberg S, Schmuckli-Maurer J, Grimm S, Heussler VT, Dobbelaere DA
Gene. 2002
PubMed ID: 12459277
Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics.
Bruno ME, Borchers CH, Dial JM, Walker NJ, Hartis JE, Wetmore BA, Carl Barrett JC, Tomer KB, Merrick BA
Arch Biochem Biophys. 2002
PubMed ID: 12361703
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U
J Biol Chem. 2002
PubMed ID: 12133833
A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta.
Fiorentino L, Stehlik C, Oliveira V, Ariza ME, Godzik A, Reed JC
J Biol Chem. 2002
PubMed ID: 12093792
Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells.
Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ
J Biol Chem. 2002
PubMed ID: 12048203
The death domain of NF-kappa B1 p105 is essential for signal-induced p105 proteolysis.
Beinke S, Belich MP, Ley SC
J Biol Chem. 2002
PubMed ID: 11976329
Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha.
Saijo K, Mecklenbräuker I, Santana A, Leitger M, Schmedt C, Tarakhovsky A
J Exp Med. 2002
PubMed ID: 12070292
The catalytic subunits of IkappaB kinase, IKK-1 and IKK-2, contain non-equivalent active sites when expressed as homodimers.
Burke JR, Strnad J
Biochem Biophys Res Commun. 2002
PubMed ID: 12054687
NEMO trimerizes through its coiled-coil C-terminal domain.
Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israël A, Véron M
J Biol Chem. 2002
PubMed ID: 11877453
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW
Mol Cell Biol. 2002
PubMed ID: 11971985
I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function.
Ren H, Schmalstieg A, van Oers NS, Gaynor RB
J Immunol. 2002
PubMed ID: 11937522
Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer.
Huynh QK, Kishore N, Mathialagan S, Donnelly AM, Tripp CS
J Biol Chem. 2002
PubMed ID: 11815618
NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases.
Bossis G, Salinas S, Cartier C, Devaux C, Briant L
FEBS Lett. 2002
PubMed ID: 11959143
Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.
Bernier-Villamor V, Sampson DA, Matunis MJ, Lima CD
Cell. 2002
PubMed ID: 11853669
Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status.
Mao Y, Mehl IR, Muller MT
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11805286
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90.
Chen G, Cao P, Goeddel DV
Mol Cell. 2002
PubMed ID: 11864612
Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6.
Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N
Mol Cell Biol. 2002
PubMed ID: 11809792
Fanconi anemia protein complex is a novel target of the IKK signalsome.
Otsuki T, Young DB, Sasaki DT, Pando MP, Li J, Manning A, Hoekstra M, Hoatlin ME, Mercurio F, Liu JM
J Cell Biochem. 2002
PubMed ID: 12210728
IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development.
Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M
Cell. 2001
PubMed ID: 11747812
Regulation of beta-catenin function by the IkappaB kinases.
Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB
J Biol Chem. 2001
PubMed ID: 11527961
Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.
Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM
Mol Cell Biol. 2001
PubMed ID: 11585904
A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.
Zetoune FS, Murthy AR, Shao Z, Hlaing T, Zeidler MG, Li Y, Vincenz C
Cytokine. 2001
PubMed ID: 11594795
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M
Science. 2001
PubMed ID: 11520989
Nuclear factor kappa B-inducing kinase and Ikappa B kinase-alpha signal skeletal muscle cell differentiation.
Canicio J, Ruiz-Lozano P, Carrasco M, Palacin M, Chien K, Zorzano A, Kaliman P
J Biol Chem. 2001
PubMed ID: 11279241
The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF.
Devin A, Lin Y, Yamaoka S, Li Z, Karin M, Liu Zg
Mol Cell Biol. 2001
PubMed ID: 11359906
Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40.
Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E
J Biol Chem. 2001
PubMed ID: 11278268
SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity.
Vig E, Green M, Liu Y, Yu KY, Kwon HJ, Tian J, Goebl MG, Harrington MA
J Biol Chem. 2001
PubMed ID: 11096118
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I.
Matsushima A, Kaisho T, Rennert PD, Nakano H, Kurosawa K, Uchida D, Takeda K, Akira S, Matsumoto M
J Exp Med. 2001
PubMed ID: 11238593
IkappaB kinase alpha is essential for mature B cell development and function.
Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N, Akira S
J Exp Med. 2001
PubMed ID: 11181694
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma.
Poyet JL, Srinivasula SM, Alnemri ES
J Biol Chem. 2001
PubMed ID: 11113112
Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes.
Petro JB, Khan WN
J Biol Chem. 2001
PubMed ID: 11042193
Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor.
You M, Flick LM, Yu D, Feng GS
J Exp Med. 2001
PubMed ID: 11136824
IFNalpha/beta promotes cell survival by activating NF-kappa B.
Yang CH, Murti A, Pfeffer SR, Basu L, Kim JG, Pfeffer LM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11095741
IKKalpha-/- mice share phenotype with pupoid fetus (pf/pf) and repeated epilation (Er/Er) mutant mice.
Fisher C
Trends Genet. 2000
PubMed ID: 11203384
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
IkappaB kinase alpha is essential for development of the mammalian cornea and conjunctiva.
Yoshida K, Hu Y, Karin M
Invest Ophthalmol Vis Sci. 2000
PubMed ID: 11053261
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.
Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ
Cell. 2000
PubMed ID: 11057907
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Activation of the NF-kappaB pathway by caspase 8 and its homologs.
Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L
Oncogene. 2000
PubMed ID: 11002417
CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.
Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10962033
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.
May MJ, D'Acquisto F, Madge LA, Glöckner J, Pober JS, Ghosh S
Science. 2000
PubMed ID: 10968790
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation.
Li Q, Estepa G, Memet S, Israel A, Verma IM
Genes Dev. 2000
PubMed ID: 10898787
Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain.
Xiao G, Sun SC
J Biol Chem. 2000
PubMed ID: 10887201
PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.
Bonnet MC, Weil R, Dam E, Hovanessian AG, Meurs EF
Mol Cell Biol. 2000
PubMed ID: 10848580
Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells.
Wooten MW, Seibenhener ML, Neidigh KB, Vandenplas ML
Mol Cell Biol. 2000
PubMed ID: 10848576
Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity.
Kwak YT, Guo J, Shen J, Gaynor RB
J Biol Chem. 2000
PubMed ID: 10747982
IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.
Yamamoto Y, Yin MJ, Gaynor RB
Mol Cell Biol. 2000
PubMed ID: 10779355
Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements.
McKenzie FR, Connelly MA, Balzarano D, Müller JR, Geleziunas R, Marcu KB
Mol Cell Biol. 2000
PubMed ID: 10733566
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.
Hehner SP, Hofmann TG, Ushmorov A, Dienz O, Wing-Lan Leung I, Lassam N, Scheidereit C, Dröge W, Schmitz ML
Mol Cell Biol. 2000
PubMed ID: 10713178
Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.
Gil J, Alcamí J, Esteban M
Oncogene. 2000
PubMed ID: 10723127
Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation.
Zhang SQ, Kovalenko A, Cantarella G, Wallach D
Immunity. 2000
PubMed ID: 10755617
The I kappa B/NF-kappa B system: a key determinant of mucosalinflammation and protection.
Jobin C, Sartor RB
Am J Physiol Cell Physiol. 2000
PubMed ID: 10712233
NF-kappaB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase.
Zamanian-Daryoush M, Mogensen TH, DiDonato JA, Williams BR
Mol Cell Biol. 2000
PubMed ID: 10648614
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.
Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W
J Biol Chem. 1999
PubMed ID: 10521409
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
Chaudhary PM, Jasmin A, Eby MT, Hood L
Oncogene. 1999
PubMed ID: 10523854
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling.
Romashkova JA, Makarov SS
Nature. 1999
PubMed ID: 10485711
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB
Nature. 1999
PubMed ID: 10485710
NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes.
Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C
EMBO J. 1999
PubMed ID: 10469655
IKK1-deficient mice exhibit abnormal development of skin and skeleton.
Li Q, Lu Q, Hwang JY, Büscher D, Lee KF, Izpisua-Belmonte JC, Verma IM
Genes Dev. 1999
PubMed ID: 10346820
IkappaB kinases: kinsmen with different crafts.
May MJ, Ghosh S
Science. 1999
PubMed ID: 10232975
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.
Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M
Science. 1999
PubMed ID: 10195896
Limb and skin abnormalities in mice lacking IKKalpha.
Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S
Science. 1999
PubMed ID: 10195895
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.
Delhase M, Hayakawa M, Chen Y, Karin M
Science. 1999
PubMed ID: 10195894
Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation.
Sakurai H, Miyoshi H, Toriumi W, Sugita T
J Biol Chem. 1999
PubMed ID: 10187861
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K
Nature. 1999
PubMed ID: 10094049
In vivo and in vitro recruitment of an IkappaBalpha-ubiquitin ligase to IkappaBalpha phosphorylated by IKK, leading to ubiquitination.
Suzuki H, Chiba T, Kobayashi M, Takeuchi M, Furuichi K, Tanaka K
Biochem Biophys Res Commun. 1999
PubMed ID: 10066434
A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways.
Maniatis T
Genes Dev. 1999
PubMed ID: 10072378
A mouse chromosome 19 genetic map including the Lvis1 viral insertion site.
Hansen GM, Tackles D, Schwartz C, Justice MJ
Genomics. 1999
PubMed ID: 10051411
Activation of IkappaB kinase beta by protein kinase C isoforms.
Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J
Mol Cell Biol. 1999
PubMed ID: 10022904
IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.
Mercurio F, Murray BW, Shevchenko A, Bennett BL, Young DB, Li JW, Pascual G, Motiwala A, Zhu H, Mann M, Manning AM
Mol Cell Biol. 1999
PubMed ID: 9891086
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases.
Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC
Immunity. 1999
PubMed ID: 10072079
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.
Nemoto S, DiDonato JA, Lin A
Mol Cell Biol. 1998
PubMed ID: 9819420
IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.
Hu MC, Wang Y
Gene. 1998
PubMed ID: 9813230
Molecular determinants of NF-kappaB-inducing kinase action.
Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WC
Mol Cell Biol. 1998
PubMed ID: 9742107
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
Rothwarf DM, Zandi E, Natoli G, Karin M
Nature. 1998
PubMed ID: 9751060
IKAP is a scaffold protein of the IkappaB kinase complex.
Cohen L, Henzel WJ, Baeuerle PA
Nature. 1998
PubMed ID: 9751059
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.
Arch RH, Gedrich RW, Thompson CB
Genes Dev. 1998
PubMed ID: 9744859
MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta.
Lee FS, Peters RT, Dang LC, Maniatis T
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9689078
DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.
Liu L, Kwak YT, Bex F, García-Martínez LF, Li XH, Meek K, Lane WS, Gaynor RB
Mol Cell Biol. 1998
PubMed ID: 9632806
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.
Ling L, Cao Z, Goeddel DV
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9520446
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H, Okumura K
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9520401
Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern.
Grimm C, Chatterjee B, Favor J, Immervoll T, Löster J, Klopp N, Sandulache R, Graw J
Dev Genet. 1998
PubMed ID: 9883582
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Ghosh S, May MJ, Kopp EB
Annu Rev Immunol. 1998
PubMed ID: 9597130
Ubch9 conjugates SUMO but not ubiquitin.
Desterro JM, Thomson J, Hay RT
FEBS Lett. 1997
PubMed ID: 9409737
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV
Science. 1997
PubMed ID: 9346485
IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A
Science. 1997
PubMed ID: 9346484
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M
Cell. 1997
PubMed ID: 9346241
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M
Nature. 1997
PubMed ID: 9252186
Identification and characterization of an IkappaB kinase.
Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M
Cell. 1997
PubMed ID: 9244310
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S
Genes Dev. 1995
PubMed ID: 7590248
CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19.
Mock BA, Connelly MA, McBride OW, Kozak CA, Marcu KB
Genomics. 1995
PubMed ID: 7558004
CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.
Connelly MA, Marcu KB
Cell Mol Biol Res. 1995
PubMed ID: 8777433
A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerization.
Ganchi PA, Sun SC, Greene WC, Ballard DW
Mol Cell Biol. 1993
PubMed ID: 8246997

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1147	12675	309361
EnsEMBL Gene(s)	ENSG00000213341	ENSMUSG00000025199	ENSRNOG00000022485
Unigene	Hs.198998	Mm.3996	Rn.23019
Homologene	CHUK	Chuk	Chuk
OMIM	600664	N/A	N/A
GeneCards	CHUK	N/A	N/A
Beta Cell Genomics	DT.100675447 DT.100814684 DT.101978418 DT.454093 DT.98083593	DT.101285624 DT.533455 DT.94158624 DT.97346809	N/A
Reactome	O15111	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1147	12675	309361

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CHUK	TANK	HPRD	empirical	12133833
CHUK	TUBB4A	MINT, IntAct	empirical	14743216
CHUK	UBE2E3	HPRD	empirical	9409737
CHUK	MYL12A	MINT, IntAct	empirical	14743216
CHUK	TRAF3IP2	BioGRID	empirical	10962033
CHUK	COPS5	BioGRID	empirical	19656241
CHUK	CHEK1	HPRD	empirical	17962807
CHUK	CDC37	HPRD, MINT, IntAct, BioGRID	empirical	11864612 14743216 21903422
CHUK	CHUK	HPRD, IntAct, BioGRID	empirical	9520446 14743216 10755617 9346485 11585904
CHUK	CLTC	IntAct	empirical	14743216
CHUK	MAP3K8	HPRD, BioGRID	empirical	10072079
CHUK	TRIM40	BioGRID	empirical	21474709
CHUK	FAM92A1	IntAct	empirical	15102471
CHUK	CREBBP	HPRD, MINT, IntAct	empirical	12789342 11971985
CHUK	CSF2RA	HPRD	empirical	12637324
CHUK	NLRP4	HPRD	empirical	12093792
CHUK	CTNNB1	HPRD, BioGRID	empirical	11527961
CHUK	DSP	IntAct	empirical	15102471
CHUK	DUSP1	BioGRID	empirical	10022904
CHUK	EEF1A2	IntAct	empirical	14743216
CHUK	TUBB	MINT, IntAct	empirical	14743216
CHUK	EP300	BioGRID	empirical	19838210
CHUK	AKT1	HPRD, BioGRID	empirical	10485710 10485711 15800029
CHUK	AKT2	HPRD, BioGRID	empirical	12048203
CHUK	ESR1	HPRD	empirical	15808510
CHUK	FKBP5	HPRD, MINT, IntAct	empirical	14743216
CHUK	FOXO3	HPRD	empirical	15084260
CHUK	ARFIP2	IntAct	empirical	15102471
CHUK	TRPC4AP	HPRD, BioGRID	empirical	14585990
CHUK	GIT1	IntAct	empirical	15102471
CHUK	HTT	BioGRID	empirical	20026656
CHUK	ANXA13	IntAct	empirical	15102471
CHUK	HSPA1A	MINT, IntAct	empirical	14743216
CHUK	HSPA9	IntAct	empirical	14743216
CHUK	HSP90AA1	HPRD, MINT, IntAct	empirical	11864612 14743216 19875381
CHUK	HSP90AB1	HPRD, MINT, IntAct	empirical	14743216
CHUK	IKBKB	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	16286467 14743216 16498412 10733566 20434986 9751060 11971985 16319058 9346241 11864612 12210728 10968790 9346485 11057907 11585904 9346484 20932476 21903422 17047224 17728323 9744859 11460167 15145317 9008162 17496917 19666475 9689078 16115877 12221085
CHUK	IRAK1	BioGRID	empirical	11096118 18180283
CHUK	IRF5	BioGRID	empirical	19786094
CHUK	IRF7	IntAct	empirical	16612387
CHUK	IRS1	HPRD, BioGRID	empirical	12351658
CHUK	KRT10	IntAct	empirical	15102471
CHUK	ARRB2	IntAct	empirical	17620599
CHUK	MAP3K3	MINT, IntAct	empirical	14743216
CHUK	MAP3K11	HPRD, BioGRID	empirical	10713178
CHUK	MYC	IntAct	empirical	21575199
CHUK	MYH9	MINT, IntAct	empirical	14743216
CHUK	MYH10	IntAct	empirical	14743216
CHUK	MYL6	MINT, IntAct	empirical	14743216
CHUK	MYO1D	MINT, IntAct	empirical	14743216
CHUK	NEDD8	BioGRID	empirical	21474709
CHUK	NFKB1	HPRD, MINT, BioGRID	empirical	11976329 14743216 10469655
CHUK	NFKB2	HPRD, MINT, IntAct, BioGRID	empirical	14743216 18617892 16303288 15140882
CHUK	NFKBIA	HPRD, MINT, IntAct, BioGRID	empirical	9244310 9252186 11809792 11042193 15389589 11095741 14743216 9520446 10733566 12730857 21765415 16286467 9751059 9346485 10094049 12054687 10066434 20932476
CHUK	NFKBIB	HPRD, MINT, IntAct, BioGRID	empirical	9689078 9252186 14743216 9346485
CHUK	NFKBIE	MINT, IntAct	empirical	14743216
CHUK	NOTCH3	HPRD, MINT	empirical	17289033 16498412
CHUK	PEBP1	HPRD, BioGRID	empirical	11585904
CHUK	TRIM44	IntAct	empirical	15102471
CHUK	PPM1B	BioGRID	empirical	14585847
CHUK	STAP2	HPRD, IntAct	empirical	16365431
CHUK	PRKCB	HPRD	empirical	12070292
CHUK	PRKCD	BioGRID	empirical	10022904
CHUK	PRKCI	HPRD, BioGRID	empirical	10848576 10022904
CHUK	PRKCQ	HPRD, BioGRID	empirical	15802604 20164171
CHUK	PRKDC	HPRD, BioGRID	empirical	9632806
CHUK	EIF2AK2	HPRD, MIPS	empirical	10648614
CHUK	PBXIP1	IntAct	empirical	15102471
CHUK	MAVS	IntAct	empirical	16177806
CHUK	PTPN11	HPRD	empirical	11136824
CHUK	PTPRS	IntAct	empirical	15102471
CHUK	PEX5	IntAct	empirical	15102471
CHUK	RAB5A	IntAct	empirical	15102471
CHUK	RELA	HPRD, MINT, IntAct, BioGRID	empirical	12842894 16046471 14743216 8246997 16382138 15489227 21903422
CHUK	RELB	MINT, IntAct	empirical	14743216
CHUK	RPL27	IntAct	empirical	21988832
CHUK	SRC	HPRD, IntAct	empirical	12707358 15749833
CHUK	MAP3K7	HPRD, IntAct, BioGRID	empirical	10187861 10094049 9742107
CHUK	CNTN2	BioGRID	empirical	17891179 16424386
CHUK	TGFBR1	HPRD	empirical	15761153
CHUK	ACTG1	IntAct	empirical	14743216
CHUK	TNF	BioGRID	empirical	20005846
CHUK	TNFAIP3	HPRD, BioGRID	empirical	11594795
CHUK	TNFRSF1A	HPRD	empirical	10755617
CHUK	TP53	HPRD	empirical	11805286
CHUK	TP73	BioGRID	empirical	17452332
CHUK	TPM3	MINT, IntAct	empirical	14743216
CHUK	NR2C2	HPRD	empirical	12547194
CHUK	TRAF2	HPRD	empirical	11359906
CHUK	UBC	BioGRID	empirical	21139048 21906983
CHUK	UBE2I	BioGRID	empirical	11853669
CHUK	UBE2N	BioGRID	empirical	11057907
CHUK	PAX8	IntAct	empirical	21988832
CHUK	CUEDC2	BioGRID	empirical	18362886
CHUK	DDX39B	IntAct	empirical	15102471
CHUK	HAUS3	IntAct	empirical	15102471
CHUK	MYH14	MINT, IntAct	empirical	14743216
CHUK	NCOA3	HPRD, IntAct	empirical	11971985
CHUK	CAPZA1	IntAct	empirical	14743216
CHUK	HIST3H3	HPRD	empirical	12789342
CHUK	CASP8	HPRD, BioGRID	empirical	11002417
CHUK	NLRC5	IntAct	empirical	20434986
CHUK	CUL1	HPRD, BioGRID	empirical	17914462
CHUK	IKBKG	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	10968790 9751060 12459277 16319058 17568778 16938294 17363973 14743216 20434986 20818435 18266467 15749833 11877453 11864612 11057907 18207244 20098747 18079694 19815509 21903422 21703539 17047224 9744859 11460167 15145317 9008162 17496917 19666475 9689078 16115877 12221085
CHUK	IKBKAP	HPRD, BioGRID	empirical	9751059 10094049
CHUK	PIAS1	HPRD	empirical	17540171
CHUK	TAX1BP1	IntAct	empirical	21765415
CHUK	BCL10	HPRD	empirical	11113112
CHUK	MAP3K14	HPRD, MINT, IntAct, BioGRID	empirical	9244310 9520446 16286467 16498412 14743216 10733566 10094049 10887201 11278268
CHUK	SESTD1	IntAct	empirical	15102471
CHUK	KIF20B	IntAct	empirical	15102471
CHUK	NCOR2	HPRD	empirical	15494311