Home TIRAP
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Regions Overlapping this Feature:
Mouse: 1
Linkage Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd2 | Mouse | chr9:32308040..98698811 | 66.39 | 764 | 6 no lod score |
(Human) GRCh37 - chr11:126152960..126168740 (15.78 kb) View in Genome Browser
(Mouse) NCBIM37 - chr9:34991976..35007876 (15.90 kb) View in Genome Browser
(Rat) RGSC3.4 - chr8:34966856..34969727 (2.87 kb) View in Genome Browser
HaemAtlas Expression Table for TIRAP:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | no data | no data | no data | no data | |||||||
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for TIRAP:The TIRAP interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| TIRAP | TIRAP | IntAct | empirical | 11544529 |
| TIRAP | TICAM1 | HPRD | empirical | 14517278 |
| TIRAP | TRAM1 | HPRD | empirical | 12721283 |
| TIRAP | APP | IntAct | empirical | 21988832 |
| TIRAP | TICAM2 | HPRD, IntAct | empirical | 12721283 |
| TIRAP | IRAK2 | HPRD, IntAct | empirical | 11544529 |
| TIRAP | MPP3 | IntAct | empirical | 21988832 |
| TIRAP | MYD88 | HPRD, MINT, IntAct | empirical | 11544529 17583698 21334391 |
| TIRAP | PCNA | IntAct | empirical | 21988832 |
| TIRAP | PRKCD | BioGRID | empirical | 17161867 |
| TIRAP | PRKCH | BioGRID | empirical | 17161867 |
| TIRAP | EIF2AK2 | HPRD | empirical | 11526399 |
| TIRAP | DNAJC3 | HPRD | empirical | 11526399 |
| TIRAP | BTK | HPRD | empirical | 16439361 16415872 12724322 |
| TIRAP | TLR4 | HPRD, IntAct | empirical | 11526399 11544529 |
| TIRAP | TRAF6 | HPRD | empirical | 15247281 |
| TIRAP | PRKRA | HPRD | empirical | 11526399 |
| TIRAP | SOCS1 | HPRD | empirical | 16415872 |
| TIRAP | IL1RL1 | HPRD | empirical | 15004556 |
| TIRAP | CD247 | HPRD | empirical | 11572860 |
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Type 1 Diabetes Publications: 1
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TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus.
Castiblanco J, Varela DC, Castaño-Rodríguez N, Rojas-Villarraga A, Hincapié ME, Anaya JM
Infect Genet Evol. 2008
PubMed ID: 18417424
Publications: 157
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TIRAP Ser180Leu polymorphism is associated with Behcet's disease.
Durrani O, Banahan K, Sheedy FJ, McBride L, Ben-Chetrit E, Greiner K, Vaughan RW, Kondeatis E, Hamburger J, Fortune F, Stanford MR, Murray PI, O'Neill LA, Wallace GR
Rheumatology (Oxford). 2011
PubMed ID: 21705416
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Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Li S, Wang L, Berman M, Kong YY, Dorf ME
Immunity. 2011
PubMed ID: 21903422
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Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.
Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, Roversi P, Kellie S, Sweet MJ, Mansell A, Gay NJ, Martin JL, Kobe B
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21873236
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Recognition of yeast nucleic acids triggers a host-protective type I interferon response.
Biondo C, Signorino G, Costa A, Midiri A, Gerace E, Galbo R, Bellantoni A, Malara A, Beninati C, Teti G, Mancuso G
Eur J Immunol. 2011
PubMed ID: 21480215
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Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.
An Y, Ohnishi H, Matsui E, Funato M, Kato Z, Teramoto T, Kaneko H, Kimura T, Kubota K, Kasahara K, Kondo N
Int J Mol Med. 2011
PubMed ID: 21399862
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Lipopolysaccharide signaling without a nucleus: kinase cascades stimulate platelet shedding of proinflammatory IL-1β-rich microparticles.
Brown GT, McIntyre TM
J Immunol. 2011
PubMed ID: 21430222
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Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility.
Miao R, Li J, Sun Z, Xu F, Shen H
Tuberculosis (Edinb). 2011
PubMed ID: 21419702
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Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis.
Tamaki Y, Takakubo Y, Hirayama T, Konttinen YT, Goodman SB, Yamakawa M, Takagi M
J Rheumatol. 2011
PubMed ID: 21324962
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Differential role of Toll-interleukin 1 receptor domain-containing adaptor protein in Toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes.
Ghose R, Guo T, Vallejo JG, Gandhi A
Drug Metab Dispos. 2011
PubMed ID: 21303924
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Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG
J Immunol. 2011
PubMed ID: 21398616
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Mal mediates TLR-induced activation of CREB and expression of IL-10.
Mellett M, Atzei P, Jackson R, O'Neill LA, Moynagh PN
J Immunol. 2011
PubMed ID: 21398611
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Pathogen recognition by the innate immune system.
Kumar H, Kawai T, Akira S
Int Rev Immunol. 2011
PubMed ID: 21235323
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IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, Mansell A, Jenkins BJ
J Immunol. 2011
PubMed ID: 21148800
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A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis.
Sweeney TE, Suliman HB, Hollingsworth JW, Welty-Wolf KE, Piantadosi CA
PLoS One. 2011
PubMed ID: 21966468
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TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.
Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH
PLoS One. 2011
PubMed ID: 21829704
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Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients.
Zakeri S, Pirahmadi S, Mehrizi AA, Djadid ND
Malar J. 2011
PubMed ID: 21457584
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population.
Zhang YX, Xue Y, Liu JY, Zhao MY, Li FJ, Zhou JM, Wang HJ, Li JC
Genet Mol Res. 2011
PubMed ID: 21218381
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Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain.
Medina EA, Morris IR, Berton MT
J Immunol. 2010
PubMed ID: 21098227
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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, Warren SE, Wewers MD, Aderem A
Nat Immunol. 2010
PubMed ID: 21057511
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Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
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TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM
Eur J Immunol. 2010
PubMed ID: 20957750
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Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
Eur J Hum Genet. 2010
PubMed ID: 20588308
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TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways.
Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E
J Immunol. 2010
PubMed ID: 20826748
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Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive haemophilus influenzae serotype b infection in immunized children.
Ladhani SN, Davila S, Hibberd ML, Heath PT, Ramsay ME, Slack MP, Pollard AJ, Booy R
Clin Infect Dis. 2010
PubMed ID: 20804371
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Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Lysakova-Devine T, Keogh B, Harrington B, Nagpal K, Halle A, Golenbock DT, Monie T, Bowie AG
J Immunol. 2010
PubMed ID: 20802145
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India.
Selvaraj P, Harishankar M, Singh B, Jawahar MS, Banurekha VV
Tuberculosis (Edinb). 2010
PubMed ID: 20797905
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Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis.
Plantinga TS, Hamza OJ, Willment JA, Ferwerda B, van de Geer NM, Verweij PE, Matee MI, Banahan K, O'neill LA, Kullberg BJ, Brown GD, van der Ven AJ, Netea MG
J Acquir Immune Defic Syndr. 2010
PubMed ID: 20577092
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IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).
Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA
J Biol Chem. 2010
PubMed ID: 20400509
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Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation.
Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS, Fessler MB
Cell Metab. 2010
PubMed ID: 20519121
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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.
Martinon F, Chen X, Lee AH, Glimcher LH
Nat Immunol. 2010
PubMed ID: 20351694
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Genetic susceptibility to different clinical forms of tuberculosis in the Peruvian population.
Taype CA, Shamsuzzaman S, Accinelli RA, Espinoza JR, Shaw MA
Infect Genet Evol. 2010
PubMed ID: 20188863
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP.
George J, Kubarenko AV, Rautanen A, Mills TC, Colak E, Kempf T, Hill AV, Nieters A, Weber AN
J Immunol. 2010
PubMed ID: 20164415
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Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways.
Dong JW, Vallejo JG, Tzeng HP, Thomas JA, Mann DL
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20061547
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AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.
Wan T, Liu T, Zhang H, Tang S, Min W
J Biol Chem. 2010
PubMed ID: 19948740
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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Cole LE, Laird MH, Seekatz A, Santiago A, Jiang Z, Barry E, Shirey KA, Fitzgerald KA, Vogel SN
J Leukoc Biol. 2010
PubMed ID: 19889726
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Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site.
Ulrichts P, Bovijn C, Lievens S, Beyaert R, Tavernier J, Peelman F
J Cell Sci. 2010
PubMed ID: 20048342
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Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.
Song Z, Tong C, Sun Z, Shen Y, Yao C, Jiang J, Yin J, Gao L, Song Y, Bai C
BMC Med Genet. 2010
PubMed ID: 21118491
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Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis.
Leal SM, Cowden S, Hsia YC, Ghannoum MA, Momany M, Pearlman E
PLoS Pathog. 2010
PubMed ID: 20617171
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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
Kumpf O, Giamarellos-Bourboulis EJ, Koch A, Hamann L, Mouktaroudi M, Oh DY, Latz E, Lorenz E, Schwartz DA, Ferwerda B, Routsi C, Skalioti C, Kullberg BJ, van der Meer JW, Schlag PM, Netea MG, Zacharowski K, Schumann RR
Crit Care. 2010
PubMed ID: 20525286
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Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
Motsinger-Reif AA, Antas PR, Oki NO, Levy S, Holland SM, Sterling TR
BMC Med Genet. 2010
PubMed ID: 20196868
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Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
Talbot S, Tötemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE
Immunology. 2009
PubMed ID: 19930040
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance.
Deng ZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S, Zhuang X, Shah SV, Sun D, Michalek S, Grizzle WE, Garvey T, Mobley J, Zhang HG
Diabetes. 2009
PubMed ID: 19675137
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Association of the toll-like receptor 2 A-16934T promoter polymorphism with severe atopic dermatitis.
Oh DY, Schumann RR, Hamann L, Neumann K, Worm M, Heine G
Allergy. 2009
PubMed ID: 19627277
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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT
J Biol Chem. 2009
PubMed ID: 19509286
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MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Kenny EF, Talbot S, Gong M, Golenbock DT, Bryant CE, O'Neill LA
J Immunol. 2009
PubMed ID: 19717524
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MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
Verstak B, Nagpal K, Bottomley SP, Golenbock DT, Hertzog PJ, Mansell A
J Biol Chem. 2009
PubMed ID: 19592497
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Long-term exposure to IL-1beta enhances Toll-IL-1 receptor-mediated inflammatory signaling in murine airway hyperresponsiveness.
Zhang Y, Xu CB, Cardell LO
Eur Cytokine Netw. 2009
PubMed ID: 19825525
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Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
Santos-Sierra S, Deshmukh SD, Kalnitski J, Küenzi P, Wymann MP, Golenbock DT, Henneke P
EMBO J. 2009
PubMed ID: 19574958
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Bauernfeind FG, Horvath G, Stutz A, Alnemri ES, MacDonald K, Speert D, Fernandes-Alnemri T, Wu J, Monks BG, Fitzgerald KA, Hornung V, Latz E
J Immunol. 2009
PubMed ID: 19570822
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Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19509334
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Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy.
Ramasawmy R, Cunha-Neto E, Fae KC, Borba SC, Teixeira PC, Ferreira SC, Goldberg AC, Ianni B, Mady C, Kalil J
J Infect Dis. 2009
PubMed ID: 19456234
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Toll-like receptor signaling pathway variants and prostate cancer mortality.
Stark JR, Wiklund F, Grönberg H, Schumacher F, Sinnott JA, Stampfer MJ, Mucci LA, Kraft P
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19505919
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Induction of distinct TLR2-mediated proinflammatory and proadhesive signaling pathways in response to Porphyromonas gingivalis fimbriae.
Hajishengallis G, Wang M, Liang S
J Immunol. 2009
PubMed ID: 19454663
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism.
Scott MJ, Liu S, Shapiro RA, Vodovotz Y, Billiar TR
Hepatology. 2009
PubMed ID: 19296467
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Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.
Hawn TR, Scholes D, Wang H, Li SS, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM
PLoS One. 2009
PubMed ID: 20016852
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Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups.
Dissanayeke SR, Levin S, Pienaar S, Wood K, Eley B, Beatty D, Henderson H, Anderson S, Levin M
PLoS One. 2009
PubMed ID: 19693265
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Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.
Hamann L, Kumpf O, Schuring RP, Alpsoy E, Bedu-Addo G, Bienzle U, Oskam L, Mockenhaupt FP, Schumann RR
BMC Med Genet. 2009
PubMed ID: 19602285
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Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.
Hawn TR, Scholes D, Li SS, Wang H, Yang Y, Roberts PL, Stapleton AE, Janer M, Aderem A, Stamm WE, Zhao LP, Hooton TM
PLoS One. 2009
PubMed ID: 19543401
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Analysis of ubiquitin degradation and phosphorylation of proteins.
Gray P
Methods Mol Biol. 2009
PubMed ID: 19378034
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MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling.
Ulrichts P, Lemmens I, Lavens D, Beyaert R, Tavernier J
Methods Mol Biol. 2009
PubMed ID: 19378012
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Toll-like receptor polymorphisms in malaria-endemic populations.
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Immunology. 2007
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Curr Biol. 2007
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TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium.
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Genes Immun. 2007
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Nat Genet. 2007
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J Immunol. 2007
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Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling.
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Nat Immunol. 2006
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Cell. 2006
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J Biol Chem. 2006
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Human chromosome 11 DNA sequence and analysis including novel gene identification.
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Nature. 2006
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Nat Immunol. 2006
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The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk.
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Cancer Epidemiol Biomarkers Prev. 2005
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Science. 2005
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Science. 2005
PubMed ID: 16141072
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J Immunol. 2005
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Mol Cell Biol. 2005
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Nature. 2005
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Genome Res. 2004
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J Biol Chem. 2004
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J Immunol. 2004
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Trends Biochem Sci. 2004
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Proc Natl Acad Sci U S A. 2004
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Nature. 2004
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Nat Immunol. 2004
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Blood. 2004
PubMed ID: 14630816
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Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.
Kollewe C, Mackensen AC, Neumann D, Knop J, Cao P, Li S, Wesche H, Martin MU
J Biol Chem. 2004
PubMed ID: 14625308
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TIR domain-containing adaptors define the specificity of TLR signaling.
Yamamoto M, Takeda K, Akira S
Mol Immunol. 2004
PubMed ID: 14698224
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like re
Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S
J Immunol. 2003
PubMed ID: 14530355
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT
J Exp Med. 2003
PubMed ID: 14517278
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Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA
J Biol Chem. 2003
PubMed ID: 12724322
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TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.
Bin LH, Xu LG, Shu HB
J Biol Chem. 2003
PubMed ID: 12721283
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Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta.
Eto A, Muta T, Yamazaki S, Takeshige K
Biochem Biophys Res Commun. 2003
PubMed ID: 12565889
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.
Horng T, Barton GM, Flavell RA, Medzhitov R
Nature. 2002
PubMed ID: 12447442
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Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S
Nature. 2002
PubMed ID: 12447441
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Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages.
Schilling D, Thomas K, Nixdorff K, Vogel SN, Fenton MJ
J Immunol. 2002
PubMed ID: 12421970
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TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells.
Bannerman DD, Erwert RD, Winn RK, Harlan JM
Biochem Biophys Res Commun. 2002
PubMed ID: 12083783
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Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?
O'Neill LA
Trends Immunol. 2002
PubMed ID: 12072368
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Involvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharide.
Shinobu N, Iwamura T, Yoneyama M, Yamaguchi K, Suhara W, Fukuhara Y, Amano F, Fujita T
FEBS Lett. 2002
PubMed ID: 12062447
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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC
Nature. 2002
PubMed ID: 11923871
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Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules.
Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T
J Biol Chem. 2001
PubMed ID: 11572860
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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA
Nature. 2001
PubMed ID: 11544529
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TIRAP: an adapter molecule in the Toll signaling pathway.
Horng T, Barton GM, Medzhitov R
Nat Immunol. 2001
PubMed ID: 11526399
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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