ADCY6

Summary Top Help

Gene Description:

adenylate cyclase 6

Synonyms:

ADCYB, ADCY6, mKIAA0422, Adcy6, AC6, ACVI

Orthologs:

Human ADCY6 (protein-coding), Mouse Adcy6 (protein-coding), Rat Adcy6 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm34	Rat	chr7:96517746..137757704	41.24	447

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:49159975..49182820 (22.84 kb) View in Genome Browser

(Mouse) NCBIM37 - chr15:98420409..98438064 (17.66 kb) View in Genome Browser

(Rat) RGSC3.4 - chr7:137339933..137360020 (209 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ADCY6:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ADCY6:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 18

Biocarta: None available

Reactome: 28

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 34

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 117

Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.
Roos KP, Strait KA, Raphael KL, Blount MA, Kohan DE
Am J Physiol Renal Physiol. 2012
PubMed ID: 21937603
Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.
Wu CS, Lin JT, Chien CL, Chang WC, Lai HL, Chang CP, Chern Y
Mol Cell Biol. 2011
PubMed ID: 21986494
Principal role of adenylyl cyclase 6 in K⁺ channel regulation and vasodilator signalling in vascular smooth muscle cells.
Nelson CP, Rainbow RD, Brignell JL, Perry MD, Willets JM, Davies NW, Standen NB, Challiss RA
Cardiovasc Res. 2011
PubMed ID: 21606183
Filamin A is a phosphorylation target of membrane but not cytosolic adenylyl cyclase activity.
Sayner SL, Balczon R, Frank DW, Cooper DM, Stevens T
Am J Physiol Lung Cell Mol Physiol. 2011
PubMed ID: 21478251
Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.
Bogard AS, Xu C, Ostrom RS
J Pharmacol Exp Ther. 2011
PubMed ID: 21228062
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK
Mol Pharmacol. 2011
PubMed ID: 21127130
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.
Sugano Y, Lai NC, Gao MH, Firth AL, Yuan JX, Lew WY, Hammond HK
Biochem Biophys Res Commun. 2011
PubMed ID: 21195051
L-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Rangel-Barajas C, Silva I, Lopéz-Santiago LM, Aceves J, Erlij D, Florán B
Neurobiol Dis. 2011
PubMed ID: 20736067
PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.
Desch M, Schubert T, Schreiber A, Mayer S, Friedrich B, Artunc F, Todorov VT
Mol Endocrinol. 2010
PubMed ID: 20861226
Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6.
Hodges GJ, Gros R, Hegele RA, Van Uum S, Shoemaker JK, Feldman RD
J Pharmacol Exp Ther. 2010
PubMed ID: 20732959
Effects of cardiac overexpression of type 6 adenylyl cyclase affects on the response to chronic pressure overload.
Guellich A, Gao S, Hong C, Yan L, Wagner TE, Dhar SK, Ghaleh B, Hittinger L, Iwatsubo K, Ishikawa Y, Vatner SF, Vatner DE
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20562336
Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells.
Kwon RY, Temiyasathit S, Tummala P, Quah CC, Jacobs CR
FASEB J. 2010
PubMed ID: 20371630
Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6).
Chien CL, Wu YS, Lai HL, Chen YH, Jiang ST, Shih CM, Lin SS, Chang C, Chern Y
FEBS Lett. 2010
PubMed ID: 20466003
Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.
Yokoyama U, Minamisawa S, Katayama A, Tang T, Suzuki S, Iwatsubo K, Iwasaki S, Kurotani R, Okumura S, Sato M, Yokota S, Hammond HK, Ishikawa Y
Circ Res. 2010
PubMed ID: 20431059
Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.
Liu X, Li F, Sun SQ, Thangavel M, Kaminsky J, Balazs L, Ostrom RS
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 20348281
beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling.
Gao MH, Tang T, Miyanohara A, Feramisco JR, Hammond HK
Cell Signal. 2010
PubMed ID: 19932173
GSK3beta mediates renal response to vasopressin by modulating adenylate cyclase activity.
Rao R, Patel S, Hao C, Woodgett J, Harris R
J Am Soc Nephrol. 2010
PubMed ID: 20056751
Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.
von Hayn K, Werthmann RC, Nikolaev VO, Hommers LG, Lohse MJ, Bünemann M
Am J Physiol Cell Physiol. 2010
PubMed ID: 19889965
Adenylyl cyclase type 5 protein expression during cardiac development and stress.
Hu CL, Chandra R, Ge H, Pain J, Yan L, Babu G, Depre C, Iwatsubo K, Ishikawa Y, Sadoshima J, Vatner SF, Vatner DE
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19734365
Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6.
Werthmann RC, von Hayn K, Nikolaev VO, Lohse MJ, Bünemann M
J Physiol. 2009
PubMed ID: 19546162
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae.
Thangavel M, Liu X, Sun SQ, Kaminsky J, Ostrom RS
Cell Signal. 2009
PubMed ID: 19007881
Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction.
Jensen AM, Bae EH, Fenton RA, Nørregaard R, Nielsen S, Kim SW, Frøkiaer J
Am J Physiol Renal Physiol. 2009
PubMed ID: 18971210
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies.
Sadana R, Dessauer CW
Neurosignals. 2009
PubMed ID: 18948702
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK
J Biol Chem. 2008
PubMed ID: 18838385
Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?
Kaya F, Belin S, Diamantidis G, Fontes M
FEBS Lett. 2008
PubMed ID: 18835269
Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP.
Tovey SC, Dedos SG, Taylor EJ, Church JE, Taylor CW
J Cell Biol. 2008
PubMed ID: 18936250
Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.
Boone M, Deen PM
Pflugers Arch. 2008
PubMed ID: 18431594
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.
Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, Ostrom RS
Naunyn Schmiedebergs Arch Pharmacol. 2008
PubMed ID: 17934720
Phosphoproteome of resting human platelets.
Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schütz C, Walter U, Gambaryan S, Sickmann A
J Proteome Res. 2008
PubMed ID: 18088087
Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation.
Creighton J, Zhu B, Alexeyev M, Stevens T
J Cell Sci. 2008
PubMed ID: 18073242
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.
Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK
Circulation. 2008
PubMed ID: 18071070
Increased enzyme activity and beta-adrenergic mediated vasodilation in subjects expressing a single-nucleotide variant of human adenylyl cyclase 6.
Gros R, Van Uum S, Hutchinson-Jaffe A, Ding Q, Pickering JG, Hegele RA, Feldman RD
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17916776
MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster.
Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D
J Biol Chem. 2007
PubMed ID: 17597072
Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.
Michalski N, Michel V, Bahloul A, Lefèvre G, Barral J, Yagi H, Chardenoux S, Weil D, Martin P, Hardelin JP, Sato M, Petit C
J Neurosci. 2007
PubMed ID: 17567809
Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.
Gao X, Sadana R, Dessauer CW, Patel TB
J Biol Chem. 2007
PubMed ID: 17110384
Role of the calcium modulated cyclases in the development of the retinal projections.
Nicol X, Bennis M, Ishikawa Y, Chan GC, Repérant J, Storm DR, Gaspar P
Eur J Neurosci. 2006
PubMed ID: 17229090
Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts.
Rhim JH, Jang IS, Yeo EJ, Song KY, Park SC
Aging Cell. 2006
PubMed ID: 17081159
The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.
Grünberger C, Obermayer B, Klar J, Kurtz A, Schweda F
Circ Res. 2006
PubMed ID: 17068292
Adenylyl cyclase 6 overexpression decreases the permeability of endothelial monolayers via preferential enhancement of prostacyclin receptor function.
Bundey RA, Insel PA
Mol Pharmacol. 2006
PubMed ID: 16885208
Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver.
Merlen C, Fabrega S, Desbuquois B, Unson CG, Authier F
FEBS Lett. 2006
PubMed ID: 17010343
Adenylylcyclase gene transfer increases function of the failing heart.
Rebolledo B, Lai NC, Gao MH, Takahashi T, Roth DM, Baird SM, Hammond HK
Hum Gene Ther. 2006
PubMed ID: 17007567
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD
Mol Cell. 2006
PubMed ID: 16973443
Adenosine 2b receptor (A2bR) signals through adenylate cyclase (AC) 6 isoform in the intestinal epithelial cells.
Kolachala VL, Obertone TS, Wang L, Merlin D, Sitaraman SV
Biochim Biophys Acta. 2006
PubMed ID: 16631311
Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.
Visel A, Alvarez-Bolado G, Thaller C, Eichele G
J Comp Neurol. 2006
PubMed ID: 16615126
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands.
Han S, Kim TD, Ha DC, Kim KT
J Biol Chem. 2005
PubMed ID: 16166080
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes.
Head BP, Patel HH, Roth DM, Lai NC, Niesman IR, Farquhar MG, Insel PA
J Biol Chem. 2005
PubMed ID: 15961389
Protein kinase C and epidermal growth factor stimulation of Raf1 potentiates adenylyl cyclase type 6 activation in intact cells.
Beazely MA, Alan JK, Watts VJ
Mol Pharmacol. 2005
PubMed ID: 15470083
A neurogenomics approach to gene expression analysis in the developing brain.
Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T
Brain Res Mol Brain Res. 2004
PubMed ID: 15582152
Indomethacin enhances shuttling of aquaporin-2 despite decreased abundance in rat kidney.
Kim SW, Kim JW, Choi KC, Ma SK, Oh Y, Jung JY, Kim J, Lee J
J Am Soc Nephrol. 2004
PubMed ID: 15579502
Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
Sampson LJ, Hayabuchi Y, Standen NB, Dart C
Circ Res. 2004
PubMed ID: 15499025
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD
Mol Pharmacol. 2004
PubMed ID: 15385642
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
Gao MH, Tang T, Guo T, Sun SQ, Feramisco JR, Hammond HK
J Biol Chem. 2004
PubMed ID: 15231818
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
An important functional role of the N terminus domain of type VI adenylyl cyclase in Galphai-mediated inhibition.
Kao YY, Lai HL, Hwang MJ, Chern Y
J Biol Chem. 2004
PubMed ID: 15192109
Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes.
Ostrom RS, Bundey RA, Insel PA
J Biol Chem. 2004
PubMed ID: 15007069
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Ikoma E, Tsunematsu T, Nakazawa I, Shiwa T, Hibi K, Ebina T, Mochida Y, Toya Y, Hori H, Uchino K, Minamisawa S, Kimura K, Umemura S, Ishikawa Y
J Cardiovasc Pharmacol. 2003
PubMed ID: 14871025
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts.
Oshikawa J, Toya Y, Fujita T, Egawa M, Kawabe J, Umemura S, Ishikawa Y
Am J Physiol Cell Physiol. 2003
PubMed ID: 12748066
Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts.
Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG
J Biol Chem. 2003
PubMed ID: 12711600
Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules.
Celano M, Arturi F, Presta I, Bruno R, Scarpelli D, Calvagno MG, Cristofaro C, Bulotta S, Giannasio P, Sacco R, Filetti S, Russo D
Mol Cell Endocrinol. 2003
PubMed ID: 12782409
Glucagon and regulation of glucose metabolism.
Jiang G, Zhang BB
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12626323
Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S, Nakajima D, Nagase T, Ohara O, Koga H
DNA Res. 2003
PubMed ID: 12693553
Localization of cyclic nucleotide phosphodiesterase 2 in the brain-derived Triton-insoluble low-density fraction (raft).
Noyama K, Maekawa S
Neurosci Res. 2003
PubMed ID: 12573460
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.
Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH
J Biol Chem. 2002
PubMed ID: 12297500
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T
DNA Res. 2002
PubMed ID: 12168954
Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.
Sunahara RK, Taussig R
Mol Interv. 2002
PubMed ID: 14993377
Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains.
Lin TH, Lai HL, Kao YY, Sun CN, Hwang MJ, Chern Y
J Biol Chem. 2002
PubMed ID: 11877398
Zinc inhibition of cAMP signaling.
Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC
J Biol Chem. 2002
PubMed ID: 11805091
Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.
Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, Lass-Flörl C, Dierich MP
J Virol. 2002
PubMed ID: 11884542
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
Ludwig MG, Seuwen K
J Recept Signal Transduct Res. 2002
PubMed ID: 12503609
Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.
Meneray MA, Lallier TE
Adv Exp Med Biol. 2002
PubMed ID: 12613887
Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes.
Serazin-Leroy V, Morot M, de Mazancourt P, Giudicelli Y
Biochim Biophys Acta. 2001
PubMed ID: 11738086
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.
Côté M, Guillon G, Payet MD, Gallo-Payet N
J Clin Endocrinol Metab. 2001
PubMed ID: 11549699
Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries.
Jourdan KB, Mason NA, Long L, Philips PG, Wilkins MR, Morrell NW
Am J Physiol Lung Cell Mol Physiol. 2001
PubMed ID: 11350817
Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.
Patrizio M, Colucci M, Levi G
J Neurochem. 2001
PubMed ID: 11299302
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Expression of multiple adenylyl cyclase isoforms in human and dog thyroid.
Vanvooren V, Allgeier A, Cosson E, Van Sande J, Defer N, Pirlot M, Hanoune J, Dumont JE
Mol Cell Endocrinol. 2000
PubMed ID: 11162902
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Wicker R, Catalan AG, Cailleux A, Starenki D, Stengel D, Sarasin A, Suarez HG
Biochim Biophys Acta. 2000
PubMed ID: 10978539
Cellular localization of type 5 and type 6 ACs in collecting duct and regulation of cAMP synthesis.
Héliès-Toussaint C, Aarab L, Gasc JM, Verbavatz JM, Chabardès D
Am J Physiol Renal Physiol. 2000
PubMed ID: 10894801
Cyclic adenosine monophosphate signaling in the rat vomeronasal organ: role of an adenylyl cyclase type VI.
Rössler P, Kroner C, Krieger J, Löbel D, Breer H, Boekhoff I
Chem Senses. 2000
PubMed ID: 10866989
gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.
Patke CL, Shearer WT
J Allergy Clin Immunol. 2000
PubMed ID: 10808179
HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.
Speth C, Joebstl B, Barcova M, Dierich MP
AIDS. 2000
PubMed ID: 10807185
Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.
Raimundo S, Giray J, Volff JN, Schwab M, Altenbuchner J, Ratge D, Wisser H
Clin Chim Acta. 1999
PubMed ID: 10481931
Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.
Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich MP
Pflugers Arch. 1999
PubMed ID: 10089566
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.
Suzuki Y, Shen T, Poyard M, Best-Belpomme M, Hanoune J, Defer N
Am J Physiol. 1998
PubMed ID: 9611134
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR
Science. 1997
PubMed ID: 9417641
Molecular diversity of adenylyl cyclases in human and rat myometrium. Correlation with global adenylyl cyclase activity during mid- and term pregnancy.
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J Biol Chem. 1997
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Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
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DNA Res. 1997
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Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
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Gene. 1997
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Differential regulation of adenylyl cyclases by Galphas.
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J Biol Chem. 1997
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Purification and characterization of a soluble form of mammalian adenylyl cyclase.
Dessauer CW, Gilman AG
J Biol Chem. 1996
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Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.
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Mamm Genome. 1995
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Mammalian adenylyl cyclase family members are randomly located on different chromosomes.
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Hum Genet. 1994
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Mechanism of GTP hydrolysis by G-protein alpha subunits.
Kleuss C, Raw AS, Lee E, Sprang SR, Gilman AG
Proc Natl Acad Sci U S A. 1994
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Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.
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Hum Genet. 1994
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Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
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Gene. 1994
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A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.
Hellevuo K, Yoshimura M, Kao M, Hoffman PL, Cooper DM, Tabakoff B
Biochem Biophys Res Commun. 1993
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Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI.
Krupinski J, Lehman TC, Frankenfield CD, Zwaagstra JC, Watson PA
J Biol Chem. 1992
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Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation.
Premont RT, Jacobowitz O, Iyengar R
Endocrinology. 1992
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Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.
Premont RT, Chen J, Ma HW, Ponnapalli M, Iyengar R
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1409703
Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.
Yoshimura M, Cooper DM
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1379717
cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.
Taylor SS, Buechler JA, Yonemoto W
Annu Rev Biochem. 1990
PubMed ID: 2165385

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	112	11512	25289
EnsEMBL Gene(s)	ENSG00000174233	ENSMUSG00000022994	ENSRNOG00000011587
Unigene	Hs.525401	Mm.157091	Rn.3313
Homologene	ADCY6	Adcy6	Adcy6
OMIM	600294	N/A	N/A
GeneCards	ADCY6	N/A	N/A
Beta Cell Genomics	DT.40108164 DT.453565 DT.91743387 DT.99937161	DT.101295866 DT.50316788 DT.94164987	N/A
Reactome	O43306	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	112	11512	25289

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Interactor	Interactor	Sources	Classification	Pubmed IDs
ADCY6	FEM1B	Sanger Interaction Map	predicted	15345047
ADCY6	CHRNA7	HPRD, BioGRID	empirical	12748066
ADCY6	GNAS	HPRD, BioGRID	empirical	9228084
ADCY6	LAMC1	Sanger Interaction Map	predicted	15345047
ADCY6	RAF1	HPRD	empirical	15470083
ADCY6	ATXN1	HPRD, MINT, IntAct	empirical	16713569
ADCY6	UBC	BioGRID	empirical	21139048 21890473