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CXCR6

Gene Description:   chemokine (C-X-C motif) receptor 6; chemokine receptor CXCR6 Synonyms:   BONZO, CXCR6, STRL33, BB217514, Cxcr6, TYMSTR, CD186 Orthologs:   Human CXCR6 (protein-coding), Mouse Cxcr6 (protein-coding), Rat Cxcr6 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, KEGG Human-Rat: OrthoMCL, KEGG Mouse-Rat: KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
3p21.31	Human	chr3:45980673..46654132	0.67	77	rs333 rs11711054

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 3p21.31 Orthologous Region	Mouse	chr9:123713859..124045161	0.33	9
Human 3p21.31 Orthologous Region	Rat	chr8:128563968..128916583	0.35	8

(Human) GRCh37 - chr3:45982425..45989845 (7.42 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr9:123715595..123720872 (5.28 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr8:128569564..128570619 (15 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                 no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for CXCR6: The CXCR6 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs CXCR6   CXCL16   HPRD, Reactome  empirical  11017100  11290797  9166430  11060282

View all

KEGG Network: 2   Chemokine signaling pathway Human - 4062 Mouse - 4062 Rat - 4062 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060

Biocarta: None available   None available.

Reactome: 7   Chemokine receptors bind chemokines REACT_15344 Class A/1 (Rhodopsin-like receptors) REACT_14828 G alpha (i) signalling events REACT_19231 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Peptide ligand-binding receptors REACT_14819 Signaling by GPCR REACT_14797

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 9   Signal transducer activity GO:0004871 Receptor activity GO:0004872 G-protein coupled receptor activity GO:0004930 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 G-protein coupled receptor protein signaling pathway GO:0007186 Coreceptor activity GO:0015026 C-X-C chemokine receptor activity GO:0016494 Viral genome replication GO:0019079

	KEGG Network: 2 Chemokine signaling pathway Human - 4062 Mouse - 4062 Rat - 4062 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060
	Biocarta: None available
	Reactome: 7 Chemokine receptors bind chemokines REACT_15344 Class A/1 (Rhodopsin-like receptors) REACT_14828 G alpha (i) signalling events REACT_19231 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Peptide ligand-binding receptors REACT_14819 Signaling by GPCR REACT_14797
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 9 Signal transducer activity GO:0004871 Receptor activity GO:0004872 G-protein coupled receptor activity GO:0004930 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 G-protein coupled receptor protein signaling pathway GO:0007186 Coreceptor activity GO:0015026 C-X-C chemokine receptor activity GO:0016494 Viral genome replication GO:0019079

Publications: 77

• Clinical significance of CXCL16/CXCR6 expression in patients with prostate cancer.
  Ha HK, Lee W, Park HJ, Lee SD, Lee JZ, Chung MK
  Mol Med Report. 2011
  PubMed ID: 21468586
   
  
• The CXCL16 A181V mutation selectively inhibits monocyte adhesion to CXCR6 but is not associated with human coronary heart disease.
  Petit SJ, Wise EL, Chambers JC, Sehmi J, Chayen NE, Kooner JS, Pease JE
  Arterioscler Thromb Vasc Biol. 2011
  PubMed ID: 21233446
   
  
• Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis.
  Rabquer BJ, Tsou PS, Hou Y, Thirunavukkarasu E, Haines GK, Impens AJ, Phillips K, Kahaleh B, Seibold JR, Koch AE
  Arthritis Res Ther. 2011
  PubMed ID: 21303517
   
  
• Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.
  Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH
  Nat Immunol. 2010
  PubMed ID: 20972432
   
  
• Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor involved in long-term nonprogression to AIDS.
  Limou S, Coulonges C, Herbeck JT, van Manen D, An P, Le Clerc S, Delaneau O, Diop G, Taing L, Montes M, van't Wout AB, Gottlieb GS, Therwath A, Rouzioux C, Delfraissy JF, Lelièvre JD, Lévy Y, Hercberg S, Dina C, Phair J, Donfield S, Goedert JJ, Buchbinder S, Estaquier J, Schächter F, Gut I, Froguel P, Mullins JI, Schuitemaker H, Winkler C, Zagury JF
  J Infect Dis. 2010
  PubMed ID: 20704485
   
  
• [Role of CXCL16/CXCR6 axis in the metastasis of human prostate cancer].
  Zhou WH, Hu WD, Wu ZQ, Zheng XM, Wang BC
  Zhonghua Yi Xue Za Zhi. 2010
  PubMed ID: 20646641
   
  
• Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
  Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
  Vaccine. 2010
  PubMed ID: 20056178
   
  
• Expression of CXCR6 on CD8(+) T cells was up-regulated in allograft rejection.
  Jiang X, Sun W, Zhu L, Guo D, Jiang H, Ma D, Jin J, Zhao Y, Liang J
  Transpl Immunol. 2010
  PubMed ID: 20035869
   
  
• Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites.
  Kim JV, Jiang N, Tadokoro CE, Liu L, Ransohoff RM, Lafaille JJ, Dustin ML
  J Immunol Methods. 2010
  PubMed ID: 19800886
   
  
• CXCR6, a newly defined biomarker of tissue-specific stem cell asymmetric self-renewal, identifies more aggressive human melanoma cancer stem cells.
  Taghizadeh R, Noh M, Huh YH, Ciusani E, Sigalotti L, Maio M, Arosio B, Nicotra MR, Natali P, Sherley JL, La Porta CA
  PLoS One. 2010
  PubMed ID: 21203549
   
  
• Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
  Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)
  PLoS Genet. 2010
  PubMed ID: 20628624
   
  
• Transcriptional regulator Id2 controls survival of hepatic NKT cells.
  Monticelli LA, Yang Y, Knell J, D'Cruz LM, Cannarile MA, Engel I, Kronenberg M, Goldrath AW
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19884494
   
  
• Enhanced tumor metastasis in response to blockade of the chemokine receptor CXCR6 is overcome by NKT cell activation.
  Cullen R, Germanov E, Shimaoka T, Johnston B
  J Immunol. 2009
  PubMed ID: 19812206
   
  
• Chemokine C-X-C motif receptor 6 contributes to cell migration during hypoxia.
  Lin S, Sun L, Hu J, Wan S, Zhao R, Yuan S, Zhang L
  Cancer Lett. 2009
  PubMed ID: 19231068
   
  
• The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers.
  Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM
  PLoS One. 2009
  PubMed ID: 19690611
   
  
• CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway.
  Wang J, Lu Y, Wang J, Koch AE, Zhang J, Taichman RS
  Cancer Res. 2008
  PubMed ID: 19074906
   
  
• CXCR6-CXCL16 interaction in the pathogenesis of Juvenile Idiopathic Arthritis.
  Martini G, Cabrelle A, Calabrese F, Carraro S, Scquizzato E, Teramo A, Facco M, Zulian F, Agostini C
  Clin Immunol. 2008
  PubMed ID: 18760678
   
  
• Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells.
  Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron TO, Babb JS, Schneider RJ, Formenti SC, Dustin ML, Demaria S
  J Immunol. 2008
  PubMed ID: 18713980
   
  
• The chemokine CXCL16 induces migration and invasion of glial precursor cells via its receptor CXCR6.
  Hattermann K, Ludwig A, Gieselmann V, Held-Feindt J, Mentlein R
  Mol Cell Neurosci. 2008
  PubMed ID: 18619850
   
  
• Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo.
  Postea O, Koenen RR, Hristov M, Weber C, Ludwig A
  J Cell Mol Med. 2008
  PubMed ID: 18194461
   
  
• Site-directed mutagenesis of the chemokine receptor CXCR6 suggests a novel paradigm for interactions with the ligand CXCL16.
  Petit SJ, Chayen NE, Pease JE
  Eur J Immunol. 2008
  PubMed ID: 18629940
   
  
• Critical role for the chemokine receptor CXCR6 in homeostasis and activation of CD1d-restricted NKT cells.
  Germanov E, Veinotte L, Cullen R, Chamberlain E, Butcher EC, Johnston B
  J Immunol. 2008
  PubMed ID: 18566372
   
  
• CXCR6 is expressed in human prostate cancer in vivo and is involved in the in vitro invasion of PC3 and LNCap cells.
  Hu W, Zhen X, Xiong B, Wang B, Zhang W, Zhou W
  Cancer Sci. 2008
  PubMed ID: 18452560
   
  
• Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
  Luttrell LM
  Mol Biotechnol. 2008
  PubMed ID: 18240029
   
  
• Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas.
  Held-Feindt J, Rehmke B, Mentlein R, Hattermann K, Knerlich F, Hugo HH, Ludwig A, Mehdorn HM
  Glia. 2008
  PubMed ID: 18293410
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Human trophoblasts recruited T lymphocytes and monocytes into decidua by secretion of chemokine CXCL16 and interaction with CXCR6 in the first-trimester pregnancy.
  Huang Y, Zhu XY, Du MR, Li DJ
  J Immunol. 2008
  PubMed ID: 18250446
   
  
• Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids.
  Velázquez P, Cameron TO, Kinjo Y, Nagarajan N, Kronenberg M, Dustin ML
  J Immunol. 2008
  PubMed ID: 18250405
   
  
• CXCR6 identifies a putative population of retained human lung T cells characterised by co-expression of activation markers.
  Morgan AJ, Guillen C, Symon FA, Birring SS, Campbell JJ, Wardlaw AJ
  Immunobiology. 2008
  PubMed ID: 18656707
   
  
• Dissociation of heterotrimeric g proteins in cells.
  Lambert NA
  Sci Signal. 2008
  PubMed ID: 18577758
   
  
• CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall.
  Galkina E, Harry BL, Ludwig A, Liehn EA, Sanders JM, Bruce A, Weber C, Ley K
  Circulation. 2007
  PubMed ID: 17909108
   
  
• Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
  Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
  J Leukoc Biol. 2007
  PubMed ID: 17615381
   
  
• CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CD8+ cells correlates with chronic obstructive pulmonary disease severity.
  Freeman CM, Curtis JL, Chensue SW
  Am J Pathol. 2007
  PubMed ID: 17640964
   
  
• Polymorphisms of Cx(3)CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients.
  Passam AM, Sourvinos G, Krambovitis E, Miyakis S, Stavrianeas N, Zagoreos I, Spandidos DA
  AIDS Res Hum Retroviruses. 2007
  PubMed ID: 17725420
   
  
• CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis.
  Latta M, Mohan K, Issekutz TB
  Immunology. 2007
  PubMed ID: 17437534
   
  
• Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.
  Sasai K, Romer JT, Kimura H, Eberhart DE, Rice DS, Curran T
  Cancer Res. 2007
  PubMed ID: 17413002
   
  
• TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells.
  Patel DN, Bailey SR, Gresham JK, Schuchman DB, Shelhamer JH, Goldstein BJ, Foxwell BM, Stemerman MB, Maranchie JK, Valente AJ, Mummidi S, Chandrasekar B
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16870145
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy.
  Zerhouni-Layachi B, Husain M, Ross MJ, Marras D, Sunamoto M, Liu X, Klotman PE, Klotman ME
  AIDS. 2006
  PubMed ID: 16470129
   
  
• Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis.
  Nanki T, Shimaoka T, Hayashida K, Taniguchi K, Yonehara S, Miyasaka N
  Arthritis Rheum. 2005
  PubMed ID: 16200580
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Cutting edge: critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance.
  Jiang X, Shimaoka T, Kojo S, Harada M, Watarai H, Wakao H, Ohkohchi N, Yonehara S, Taniguchi M, Seino K
  J Immunol. 2005
  PubMed ID: 16081769
   
  
• Use of alternate coreceptors on primary cells by two HIV-1 isolates.
  Cilliers T, Willey S, Sullivan WM, Patience T, Pugach P, Coetzer M, Papathanasopoulos M, Moore JP, Trkola A, Clapham P, Morris L
  Virology. 2005
  PubMed ID: 15992849
   
  
• CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves' disease (GD).
  Aust G, Kamprad M, Lamesch P, Schmücking E
  Eur J Endocrinol. 2005
  PubMed ID: 15817921
   
  
• Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids.
  Geissmann F, Cameron TO, Sidobre S, Manlongat N, Kronenberg M, Briskin MJ, Dustin ML, Littman DR
  PLoS Biol. 2005
  PubMed ID: 15799695
   
  
• CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.
  Blaak H, Boers PH, Gruters RA, Schuitemaker H, van der Ende ME, Osterhaus AD
  J Virol. 2005
  PubMed ID: 15650194
   
  
• Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver.
  Sato T, Thorlacius H, Johnston B, Staton TL, Xiang W, Littman DR, Butcher EC
  J Immunol. 2005
  PubMed ID: 15611250
   
  
• Expression of chemokine receptor CXCR6 in human colorectal adenocarcinomas.
  Wågsäter D, Dimberg J
  Anticancer Res. 2004
  PubMed ID: 15736401
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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