CENPA

Summary Top Help

Gene Description:

centromere protein A

Synonyms:

CENP-A, CenH3, RGD1563607, Cenpa, CENPA, Cenp-A

Orthologs:

Human CENPA (protein-coding), Mouse Cenpa (protein-coding), Rat Cenpa (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:27008865..27023935 (157 kb) View in Genome Browser

(Mouse) NCBIM37 - chr5:30969150..30977200 (85 kb) View in Genome Browser

(Rat) RGSC3.4 - chr6:25686571..25693881 (7.31 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CENPA:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CENPA:

The CENPA interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
CENPA	CHAF1A	IntAct	empirical	19410544
CENPA	PARP2	HPRD	empirical	12217960
CENPA	CENPA	BioGRID	empirical	15009096
CENPA	CENPB	BioGRID	empirical	15009096
CENPA	CENPE	Reactome	predicted
CENPA	CENPF	Reactome	predicted
CENPA	NUDC	Reactome	predicted
CENPA	KIF2C	Reactome	predicted
CENPA	ZWINT	Reactome	predicted
CENPA	CBX3	BioGRID	empirical	15009096
CENPA	PARP1	HPRD, BioGRID	empirical	12011073
CENPA	SGOL2	Reactome	predicted
CENPA	SGOL1	Reactome	predicted
CENPA	DDB1	BioGRID	empirical	15009096
CENPA	DIAPH1	HPRD	empirical	15085137
CENPA	DIAPH2	HPRD	empirical	15085137
CENPA	FBL	BioGRID	empirical	15009096
CENPA	SKA1	Reactome	predicted
CENPA	MAPRE1	Reactome	predicted
CENPA	ZC3H13	BioGRID	empirical	15009096
CENPA	CLASP2	Reactome	predicted
CENPA	CLASP1	Reactome	predicted
CENPA	CENPI	BioGRID	empirical	15009096
CENPA	ABL1	IntAct	empirical	17474147
CENPA	FYN	IntAct	empirical	17474147
CENPA	AHCTF1	Reactome	predicted
CENPA	KIAA1429	BioGRID	empirical	15009096
CENPA	LOC284412	BioGRID	empirical	15009096
CENPA	HIST1H1C	BioGRID	empirical	15009096
CENPA	HIST1H2AD	BioGRID	empirical	15009096
CENPA	HSPA8	BioGRID	empirical	15009096
CENPA	INCENP	Reactome	predicted
CENPA	KIF2A	Reactome	predicted
CENPA	HPC3	BioGRID	empirical	15009096
CENPA	NPM1	IntAct, BioGRID	empirical	19410544 19410545
CENPA	PAFAH1B1	Reactome	predicted
CENPA	SRRT	BioGRID	empirical	15009096
CENPA	RSF1	BioGRID	empirical	15009096
CENPA	PLK1	Reactome	predicted
CENPA	NDE1	Reactome	predicted
CENPA	ERCC6L	Reactome	predicted
CENPA	CCDC99	Reactome	predicted
CENPA	PPP1CC	Reactome	predicted
CENPA	HJURP	IntAct, BioGRID	empirical	19410544 19410545 21478274 21980305
CENPA	CENPN	BioGRID	empirical	15009096
CENPA	RCC2	Reactome	predicted
CENPA	CBX8	BioGRID	empirical	15009096
CENPA	TAOK1	Reactome	predicted
CENPA	RANBP2	Reactome	predicted
CENPA	RANGAP1	Reactome	predicted
CENPA	RBBP4	IntAct	empirical	19410545
CENPA	ACTB	BioGRID	empirical	15009096
CENPA	RING1	BioGRID	empirical	15009096
CENPA	RPA1	IntAct, BioGRID	empirical	19410544
CENPA	RPS27	Reactome	predicted
CENPA	CLIP1	Reactome	predicted
CENPA	CENPK	BioGRID	empirical	15009096
CENPA	BMI1	BioGRID	empirical	15009096
CENPA	CENPH	BioGRID	empirical	15009096
CENPA	AURKC	BioGRID	empirical	20663916
CENPA	BUB1	Reactome	predicted
CENPA	XPO1	Reactome	predicted
CENPA	CENPM	BioGRID	empirical	15009096
CENPA	CENPO	BioGRID	empirical	15009096
CENPA	SHCBP1	BioGRID	empirical	15009096
CENPA	CENPT	BioGRID	empirical	15009096
CENPA	B9D2	Reactome	predicted
CENPA	ZFP91	BioGRID	empirical	15009096
CENPA	NDEL1	Reactome	predicted
CENPA	KIF18A	Reactome	predicted
CENPA	HIST2H2BE	BioGRID	empirical	15009096
CENPA	HIST1H3C	HPRD, BioGRID	empirical	15282608
CENPA	HIST1H4A	BioGRID	empirical	15009096
CENPA	HIST1H4F	HPRD	empirical	15282608
CENPA	MAD1L1	Reactome	predicted
CENPA	KIF2B	Reactome	predicted
CENPA	SMARCA5	BioGRID	empirical	15009096
CENPA	RUVBL1	IntAct, BioGRID	empirical	19410544
CENPA	AURKB	HPRD	empirical	11756469
CENPA	KIF23	BioGRID	empirical	15009096
CENPA	WTAP	BioGRID	empirical	15009096
CENPA	CKAP5	Reactome	predicted
CENPA	CDC20	Reactome	predicted

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 8

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 21

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 91

Hepatitis B virus X protein mutant upregulates CENP-A expression in hepatoma cells.
Liu L, Li Y, Zhang S, Yu D, Zhu M
Oncol Rep. 2012
PubMed ID: 21956590
Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.
Mishra PK, Au WC, Choy JS, Kuich PH, Baker RE, Foltz DR, Basrai MA
PLoS Genet. 2011
PubMed ID: 21980305
Crystal structure of the human centromeric nucleosome containing CENP-A.
Tachiwana H, Kagawa W, Shiga T, Osakabe A, Miya Y, Saito K, Hayashi-Takanaka Y, Oda T, Sato M, Park SY, Kimura H, Kurumizaka H
Nature. 2011
PubMed ID: 21743476
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore.
Barnhart MC, Kuich PH, Stellfox ME, Ward JA, Bassett EA, Black BE, Foltz DR
J Cell Biol. 2011
PubMed ID: 21768289
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.
Hu H, Liu Y, Wang M, Fang J, Huang H, Yang N, Li Y, Wang J, Yao X, Shi Y, Li G, Xu RM
Genes Dev. 2011
PubMed ID: 21478274
ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth.
Li Y, Zhu Z, Zhang S, Yu D, Yu H, Liu L, Cao X, Wang L, Gao H, Zhu M
PLoS One. 2011
PubMed ID: 21423629
Uracil DNA N-glycosylase promotes assembly of human centromere protein A.
Zeitlin SG, Chapados BR, Baker NM, Tai C, Slupphaug G, Wang JY
PLoS One. 2011
PubMed ID: 21399697
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Tetrameric organization of vertebrate centromeric nucleosomes.
Dimitriadis EK, Weber C, Gill RK, Diekmann S, Dalal Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21059934
Centromere protein A dynamics in human pluripotent stem cell self-renewal, differentiation and DNA damage.
Ambartsumyan G, Gill RK, Perez SD, Conway D, Vincent J, Dalal Y, Clark AT
Hum Mol Genet. 2010
PubMed ID: 20650959
The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead box E3 (FOXE3).
Perosa F, Vicenti C, Racanelli V, Leone P, Valentini G, Dammacco F
Clin Immunol. 2010
PubMed ID: 20630806
The structure of (CENP-A-H4)(2) reveals physical features that mark centromeres.
Sekulic N, Bassett EA, Rogers DJ, Black BE
Nature. 2010
PubMed ID: 20739937
SUMOylation modulates the function of Aurora-B kinase.
Fernández-Miranda G, Pérez de Castro I, Carmena M, Aguirre-Portolés C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M
J Cell Sci. 2010
PubMed ID: 20663916
Dual recognition of CENP-A nucleosomes is required for centromere assembly.
Carroll CW, Milks KJ, Straight AF
J Cell Biol. 2010
PubMed ID: 20566683
CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.
Maehara K, Takahashi K, Saitoh S
Mol Cell Biol. 2010
PubMed ID: 20160010
Building centromeres: home sweet home or a nomadic existence?
Buscaino A, Allshire R, Pidoux A
Curr Opin Genet Dev. 2010
PubMed ID: 20206496
HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres.
Shuaib M, Ouararhni K, Dimitrov S, Hamiche A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080577
Molecular and evolutionary characteristics of the fraction of human alpha satellite DNA associated with CENP-A at the centromeres of chromosomes 1, 5, 19, and 21.
Pironon N, Puechberty J, Roizès G
BMC Genomics. 2010
PubMed ID: 20331851
Double-strand DNA breaks recruit the centromeric histone CENP-A.
Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang JY, Berns MW, Cleveland DW
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19717431
CENP-H-containing complex facilitates centromere deposition of CENP-A in cooperation with FACT and CHD1.
Okada M, Okawa K, Isobe T, Fukagawa T
Mol Biol Cell. 2009
PubMed ID: 19625449
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.
Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF
Nat Cell Biol. 2009
PubMed ID: 19543270
Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function.
Kim H, Lee M, Lee S, Park B, Koh W, Lee DJ, Lim DS, Lee S
Mol Cells. 2009
PubMed ID: 19533040
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.
Chan YW, Fava LL, Uldschmid A, Schmitz MH, Gerlich DW, Nigg EA, Santamaria A
J Cell Biol. 2009
PubMed ID: 19468067
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.
Dunleavy EM, Roche D, Tagami H, Lacoste N, Ray-Gallet D, Nakamura Y, Daigo Y, Nakatani Y, Almouzni-Pettinotti G
Cell. 2009
PubMed ID: 19410545
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.
Foltz DR, Jansen LE, Bailey AO, Yates JR, Bassett EA, Wood S, Black BE, Cleveland DW
Cell. 2009
PubMed ID: 19410544
CENPA overexpression promotes genome instability in pRb-depleted human cells.
Amato A, Schillaci T, Lentini L, Di Leonardo A
Mol Cancer. 2009
PubMed ID: 20003272
The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation.
Trazzi S, Perini G, Bernardoni R, Zoli M, Reese JC, Musacchio A, Della Valle G
PLoS One. 2009
PubMed ID: 19503796
Three-dimensional localization of CENP-A suggests a complex higher order structure of centromeric chromatin.
Marshall OJ, Marshall AT, Choo KH
J Cell Biol. 2008
PubMed ID: 19114591
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.
Hellwig D, Münch S, Orthaus S, Hoischen C, Hemmerich P, Diekmann S
J Biophotonics. 2008
PubMed ID: 19412974
Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis.
Slattery SD, Moore RV, Brinkley BR, Hall RM
Cell Cycle. 2008
PubMed ID: 18239465
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.
Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C
Cell Res. 2008
PubMed ID: 18195732
Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells.
Orthaus S, Biskup C, Hoffmann B, Hoischen C, Ohndorf S, Benndorf K, Diekmann S
Chembiochem. 2008
PubMed ID: 18072184
The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity.
McClelland SE, Borusu S, Amaro AC, Winter JR, Belwal M, McAinsh AD, Meraldi P
EMBO J. 2007
PubMed ID: 18007590
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
PubMed ID: 17474147
Propagation of centromeric chromatin requires exit from mitosis.
Jansen LE, Black BE, Foltz DR, Cleveland DW
J Cell Biol. 2007
PubMed ID: 17339380
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.
Bertheau P, Turpin E, Rickman DS, Espié M, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de Thé H
PLoS Med. 2007
PubMed ID: 17388661
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
Genomics. 2007
PubMed ID: 17207965
Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain.
Black BE, Jansen LE, Maddox PS, Foltz DR, Desai AB, Shah JV, Cleveland DW
Mol Cell. 2007
PubMed ID: 17244537
Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.
Alonso A, Fritz B, Hasson D, Abrusan G, Cheung F, Yoda K, Radlwimmer B, Ladurner AG, Warburton PE
Genome Biol. 2007
PubMed ID: 17651496
Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.
Fujita Y, Hayashi T, Kiyomitsu T, Toyoda Y, Kokubu A, Obuse C, Yanagida M
Dev Cell. 2007
PubMed ID: 17199038
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.
Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T
Nat Cell Biol. 2006
PubMed ID: 16622420
The human CENP-A centromeric nucleosome-associated complex.
Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW
Nat Cell Biol. 2006
PubMed ID: 16622419
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin.
Sullivan BA, Karpen GH
Nat Struct Mol Biol. 2004
PubMed ID: 15475964
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Structural determinants for generating centromeric chromatin.
Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL, Cleveland DW
Nature. 2004
PubMed ID: 15282608
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S
Nature. 2004
PubMed ID: 15085137
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K
Genes Cells. 2004
PubMed ID: 15009096
Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres.
Irvine DV, Amor DJ, Perry J, Sirvent N, Pedeutour F, Choo KH, Saffery R
Chromosome Res. 2004
PubMed ID: 15702419
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function.
Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, Hatakeyama K, Ushio Y, Saya H, Hirota T
Dev Cell. 2003
PubMed ID: 14667408
Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
Craig JM, Earle E, Canham P, Wong LH, Anderson M, Choo KH
Hum Mol Genet. 2003
PubMed ID: 14519686
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer.
Tomonaga T, Matsushita K, Yamaguchi S, Oohashi T, Shimada H, Ochiai T, Yoda K, Nomura F
Cancer Res. 2003
PubMed ID: 12839935
Partially functional Cenpa-GFP fusion protein causes increased chromosome missegregation and apoptosis during mouse embryogenesis.
Kalitsis P, Fowler KJ, Earle E, Griffiths B, Howman E, Newson AJ, Choo KH
Chromosome Res. 2003
PubMed ID: 12906131
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc.
Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH
Hum Mol Genet. 2002
PubMed ID: 12217960
Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.
Saxena A, Saffery R, Wong LH, Kalitsis P, Choo KH
J Biol Chem. 2002
PubMed ID: 12011073
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Molecular cloning and sequence analysis of hamster CENP-A cDNA.
Figueroa J, Pendón C, Valdivia MM
BMC Genomics. 2002
PubMed ID: 12019018
CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells.
Ando S, Yang H, Nozaki N, Okazaki T, Yoda K
Mol Cell Biol. 2002
PubMed ID: 11884609
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.
Zeitlin SG, Shelby RD, Sullivan KF
J Cell Biol. 2001
PubMed ID: 11756469
Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A.
Van Hooser AA, Ouspenski II, Gregson HC, Starr DA, Yen TJ, Goldberg ML, Yokomori K, Earnshaw WC, Sullivan KF, Brinkley BR
J Cell Sci. 2001
PubMed ID: 11682612
Expression of genes involved in mammalian meiosis during the transition from egg to embryo.
Hwang SY, Oh B, Knowles BB, Solter D, Lee JS
Mol Reprod Dev. 2001
PubMed ID: 11389549
Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0.
Lomonte P, Sullivan KF, Everett RD
J Biol Chem. 2001
PubMed ID: 11053442
Functional annotation of a full-length mouse cDNA collection.
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Nature. 2001
PubMed ID: 11217851
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.
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Curr Biol. 2000
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
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Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3.
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	Human	Mouse	Rat
Entrez Gene	1058	12615	298850
EnsEMBL Gene(s)	ENSG00000115163	ENSMUSG00000029177	ENSRNOG00000032178
Unigene	Hs.1594	Mm.290563	Rn.16165
Homologene	CENPA	Cenpa	Cenpa
OMIM	117139	N/A	N/A
GeneCards	CENPA	N/A	N/A
Beta Cell Genomics	DT.100748001 DT.313100 DT.91749874	DT.535717 DT.94167840 DT.94168464	N/A
Reactome	P49450	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1058	12615	298850

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