NDC80

Summary Top Help

Gene Description:

NDC80 homolog, kinetochore complex component (S. cerevisiae); NDC80 kinetochore complex component homolog (S. cerevisiae)

Synonyms:

Kntc2, HEC, hsNDC80, HsHec1, AV139730, 2610020P18Rik, Ndc80, TID3, KNTC2, HEC1, NDC80

Orthologs:

Human NDC80 (protein-coding), Mouse Ndc80 (protein-coding), Rat Ndc80 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr18:2571510..2616634 (45.12 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:71845440..71876197 (30.76 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:110702935..110734129 (31.19 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for NDC80:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for NDC80:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 5

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 22

Publications from PubMed Top Help

Publications: 77

Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.
Wei R, Ngo B, Wu G, Lee WH
Mol Biol Cell. 2011
PubMed ID: 21832156
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Ndc80 regulates meiotic spindle organization, chromosome alignment, and cell cycle progression in mouse oocytes.
Sun SC, Zhang DX, Lee SE, Xu YN, Kim NH
Microsc Microanal. 2011
PubMed ID: 21600073
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.
Tooley JG, Miller SA, Stukenberg PT
Mol Biol Cell. 2011
PubMed ID: 21325630
The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis.
Sundin LJ, Guimaraes GJ, Deluca JG
Mol Biol Cell. 2011
PubMed ID: 21270439
Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis.
DeLuca KF, Lens SM, DeLuca JG
J Cell Sci. 2011
PubMed ID: 21266467
CENP-U cooperates with Hec1 to orchestrate kinetochore-microtubule attachment.
Hua S, Wang Z, Jiang K, Huang Y, Ward T, Zhao L, Dou Z, Yao X
J Biol Chem. 2011
PubMed ID: 21056971
Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy.
Bièche I, Vacher S, Lallemand F, Tozlu-Kara S, Bennani H, Beuzelin M, Driouch K, Rouleau E, Lerebours F, Ripoche H, Cizeron-Clairac G, Spyratos F, Lidereau R
Mol Cancer. 2011
PubMed ID: 21352579
Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.
Mattiuzzo M, Vargiu G, Totta P, Fiore M, Ciferri C, Musacchio A, Degrassi F
PLoS One. 2011
PubMed ID: 21297979
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway.
Ferretti C, Totta P, Fiore M, Mattiuzzo M, Schillaci T, Ricordy R, Di Leonardo A, Degrassi F
Cell Cycle. 2010
PubMed ID: 20948316
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Alushin GM, Ramey VH, Pasqualato S, Ball DA, Grigorieff N, Musacchio A, Nogales E
Nature. 2010
PubMed ID: 20944740
Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ
Breast Cancer Res Treat. 2010
PubMed ID: 20508983
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis.
Kaneko N, Miura K, Gu Z, Karasawa H, Ohnuma S, Sasaki H, Tsukamoto N, Yokoyama S, Yamamura A, Nagase H, Shibata C, Sasaki I, Horii A
Biochem Biophys Res Commun. 2009
PubMed ID: 19878654
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.
Wu G, Wei R, Cheng E, Ngo B, Lee WH
Mol Biol Cell. 2009
PubMed ID: 19776357
PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation.
Yuan K, Li N, Jiang K, Zhu T, Huo Y, Wang C, Lu J, Shaw A, Thomas K, Zhang J, Mann D, Liao J, Jin C, Yao X
J Biol Chem. 2009
PubMed ID: 19553660
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly.
Chan YW, Fava LL, Uldschmid A, Schmitz MH, Gerlich DW, Nigg EA, Santamaria A
J Cell Biol. 2009
PubMed ID: 19468067
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.
Diaz-Rodríguez E, Sotillo R, Schvartzman JM, Benezra R
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18940925
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Orientation and structure of the Ndc80 complex on the microtubule lattice.
Wilson-Kubalek EM, Cheeseman IM, Yoshioka C, Desai A, Milligan RA
J Cell Biol. 2008
PubMed ID: 18794333
[Expression and clinical significance of highly expressed protein in cancer (Hec 1) in human primary gallbladder carcinoma]
Xiao GF, Tang HH
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008
PubMed ID: 18782526
The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.
Du J, Cai X, Yao J, Ding X, Wu Q, Pei S, Jiang K, Zhang Y, Wang W, Shi Y, Lai Y, Shen J, Teng M, Huang H, Fei Q, Reddy ES, Zhu J, Jin C, Yao X
Oncogene. 2008
PubMed ID: 18297113
Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.
Ciferri C, Pasqualato S, Screpanti E, Varetti G, Santaguida S, Dos Reis G, Maiolica A, Polka J, De Luca JG, De Wulf P, Salek M, Rappsilber J, Moores CA, Salmon ED, Musacchio A
Cell. 2008
PubMed ID: 18455984
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.
Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C
Cell Res. 2008
PubMed ID: 18195732
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Functional characterization of the promoter of human kinetochore protein HEC1: novel link between regulation of the cell cycle protein and CREB family transcription factors.
Cheng L, Li L, Qiao X, Liu J, Yao X
Biochim Biophys Acta. 2007
PubMed ID: 17822787
The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.
Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V
EMBO J. 2007
PubMed ID: 17363900
The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.
Wei RR, Al-Bassam J, Harrison SC
Nat Struct Mol Biol. 2007
PubMed ID: 17195848
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.
DeLuca JG, Gall WE, Ciferri C, Cimini D, Musacchio A, Salmon ED
Cell. 2006
PubMed ID: 17129782
Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.
Lin YT, Chen Y, Wu G, Lee WH
Oncogene. 2006
PubMed ID: 16732327
Phosphoproteome analysis of the human mitotic spindle.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16565220
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
DNA sequence and analysis of human chromosome 18.
Nusbaum C, Zody MC, Borowsky ML, Kamal M, Kodira CD, Taylor TD, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Abouelleil A, Allen NR, Anderson S, Bloom T, Bugalter B, Butler J, Cook A, DeCaprio D, Engels R, Garber M, Gnirke A, Hafez N, Hall JL, Norman CH, Itoh T, Jaffe DB, Kuroki Y, Lehoczky J, Lui A, Macdonald P, Mauceli E, Mikkelsen TS, Naylor JW, Nicol R, Nguyen C, Noguchi H, O'Leary SB, O'Neill K, Piqani B, Smith CL, Talamas JA, Topham K, Totoki Y, Toyoda A, Wain HM, Young SK, Zeng Q, Zimmer AR, Fujiyama A, Hattori M, Birren BW, Sakaki Y, Lander ES
Nature. 2005
PubMed ID: 16177791
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore.
Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A
J Biol Chem. 2005
PubMed ID: 15961401
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.
Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ
Curr Biol. 2005
PubMed ID: 15964272
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer.
Glinsky GV, Berezovska O, Glinskii AB
J Clin Invest. 2005
PubMed ID: 15931389
ZW10 links mitotic checkpoint signaling to the structural kinetochore.
Kops GJ, Kim Y, Weaver BA, Mao Y, McLeod I, Yates JR, Tagaya M, Cleveland DW
J Cell Biol. 2005
PubMed ID: 15824131
The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis.
Mikami Y, Hori T, Kimura H, Fukagawa T
Mol Cell Biol. 2005
PubMed ID: 15713649
Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.
DeLuca JG, Dong Y, Hergert P, Strauss J, Hickey JM, Salmon ED, McEwen BF
Mol Biol Cell. 2005
PubMed ID: 15548592
Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC
J Biol Chem. 2005
PubMed ID: 15504738
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M
Nat Cell Biol. 2004
PubMed ID: 15502821
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A
Genes Dev. 2004
PubMed ID: 15371340
Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1.
Stucke VM, Baumann C, Nigg EA
Chromosoma. 2004
PubMed ID: 15235793
Timing and checkpoints in the regulation of mitotic progression.
Meraldi P, Draviam VM, Sorger PK
Dev Cell. 2004
PubMed ID: 15239953
Sgt1 is required for human kinetochore assembly.
Steensgaard P, Garrè M, Muradore I, Transidico P, Nigg EA, Kitagawa K, Earnshaw WC, Faretta M, Musacchio A
EMBO Rep. 2004
PubMed ID: 15133482
NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.
Lou Y, Yao J, Zereshki A, Dou Z, Ahmed K, Wang H, Hu J, Wang Y, Yao X
J Biol Chem. 2004
PubMed ID: 14978040
The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo.
Joseph J, Liu ST, Jablonski SA, Yen TJ, Dasso M
Curr Biol. 2004
PubMed ID: 15062103
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Identification of two novel components of the human NDC80 kinetochore complex.
Bharadwaj R, Qi W, Yu H
J Biol Chem. 2004
PubMed ID: 14699129
Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model.
Tien AC, Lin MH, Su LJ, Hong YR, Cheng TS, Lee YC, Lin WJ, Still IH, Huang CY
Mol Cell Proteomics. 2004
PubMed ID: 14602875
Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores.
DeLuca JG, Howell BJ, Canman JC, Hickey JM, Fang G, Salmon ED
Curr Biol. 2003
PubMed ID: 14654001
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation.
Chen Y, Riley DJ, Zheng L, Chen PL, Lee WH
J Biol Chem. 2002
PubMed ID: 12386167
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2.
Martin-Lluesma S, Stucke VM, Nigg EA
Science. 2002
PubMed ID: 12351790
Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome Res. 2001
PubMed ID: 11591653
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.
Wigge PA, Kilmartin JV
J Cell Biol. 2001
PubMed ID: 11266451
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p.
Zheng L, Chen Y, Riley DJ, Chen PL, Lee WH
Mol Cell Biol. 2000
PubMed ID: 10779342
Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins.
Zheng L, Chen Y, Lee WH
Mol Cell Biol. 1999
PubMed ID: 10409732
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis.
Chen Y, Riley DJ, Chen PL, Lee WH
Mol Cell Biol. 1997
PubMed ID: 9315664
HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins.
Chen Y, Sharp ZD, Lee WH
J Biol Chem. 1997
PubMed ID: 9295362
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.
Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, Elledge SJ
Genes Dev. 1993
PubMed ID: 8384581

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	10403	67052	301701
EnsEMBL Gene(s)	ENSG00000080986	ENSMUSG00000024056	ENSRNOG00000013727
Unigene	Hs.414407	Mm.225956	Rn.225213
Homologene	NDC80	Ndc80	Ndc80
OMIM	607272	N/A	N/A
GeneCards	NDC80	N/A	N/A
Beta Cell Genomics	DT.413766	DT.101374110 DT.485919 DT.97406008	N/A
Reactome	O14777	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	10403	67052	301701

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
NDC80	TOM1L1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
NDC80	TFG	MINT, IntAct	empirical	11591653
NDC80	NDC80	HPRD, IntAct, BioGRID	empirical	9295362 14602875 20360068
NDC80	PIBF1	IntAct, BioGRID	empirical	20360068
NDC80	CENPB	IntAct	empirical	11266451
NDC80	CENPE	IntAct	empirical	17535814
NDC80	ZWINT	HPRD, IntAct, BioGRID	empirical	16732327 15824131 20360068
NDC80	PMF1	IntAct	empirical	20360068
NDC80	CCDC101	IntAct, BioGRID	empirical	20360068
NDC80	IQGAP3	IntAct, BioGRID	empirical	20360068
NDC80	SPC24	IntAct, BioGRID, Reactome	empirical	15961401 14699129 14681455 20360068
NDC80	SKA1	MINT	empirical	17093495
NDC80	BICD2	IntAct, BioGRID	empirical	20360068
NDC80	SNAPIN	IntAct, BioGRID	empirical	20360068
NDC80	ASPM	IntAct, BioGRID	empirical	20360068
NDC80	NSL1	IntAct, BioGRID	empirical	20360068
NDC80	PLDN	HPRD, MINT, IntAct, BioGRID	empirical	16189514
NDC80	HMMR	IntAct, BioGRID	empirical	20360068
NDC80	HNRNPU	IntAct, BioGRID	empirical	20360068
NDC80	KIFC1	IntAct	empirical	20360068
NDC80	MAD2L1	HPRD	empirical	12351790
NDC80	NEK2	HPRD, BioGRID	empirical	12386167 9295362 21900206
NDC80	NPR1	IntAct, BioGRID	empirical	20360068
NDC80	CCDC53	HPRD, MINT, IntAct, BioGRID	empirical	16189514
NDC80	PCM1	IntAct, BioGRID	empirical	20360068
NDC80	AMOTL2	HPRD, IntAct, BioGRID	empirical	16189514
NDC80	PHKA2	IntAct, BioGRID	empirical	20360068
NDC80	PHKB	BioGRID	empirical	20360068
NDC80	PLCG2	MINT, IntAct	empirical	15102471
NDC80	PSMC2	HPRD	empirical	9295362
NDC80	CASC5	IntAct, BioGRID	empirical	20360068
NDC80	SPC25	HPRD, IntAct, BioGRID, Reactome	empirical	14699129 15961401 14681455 20360068
NDC80	ODF2L	IntAct, BioGRID	empirical	20360068
NDC80	BEGAIN	IntAct, BioGRID	empirical	20360068
NDC80	CALCOCO1	HPRD, MINT, IntAct, BioGRID	empirical	16189514 20360068
NDC80	EPS15L1	IntAct, BioGRID	empirical	20360068
NDC80	RB1	HPRD	empirical	10409732
NDC80	KLHL12	HPRD, MINT, IntAct, BioGRID	empirical	16189514
NDC80	RCN1	IntAct, BioGRID	empirical	20360068
NDC80	RRBP1	BioGRID	empirical	20360068
NDC80	CENPH	IntAct	empirical	15713649
NDC80	AURKA	HPRD	empirical	14602875
NDC80	BUB1	IntAct, BioGRID	empirical	20360068
NDC80	BUB1B	IntAct, BioGRID	empirical	20360068
NDC80	UBC	BioGRID	empirical	21987572 21139048 21890473 21906983
NDC80	MIS12	HPRD, IntAct, BioGRID	empirical	15502821 20360068 15371340
NDC80	MLF1IP	IntAct, BioGRID	empirical	20360068
NDC80	DSN1	IntAct, BioGRID	empirical	20360068
NDC80	SMC1A	HPRD	empirical	9295362
NDC80	NUF2	HPRD, IntAct, BioGRID, Reactome	empirical	14602875 15961401 14699129 17129783 14681455 20360068
NDC80	MAD1L1	HPRD	empirical	12351790
NDC80	USHBP1	HPRD, IntAct, BioGRID	empirical	16189514
NDC80	ZW10	IntAct	empirical	16732327
NDC80	AURKB	HPRD	empirical	14602875
NDC80	SNAP29	IntAct, BioGRID	empirical	20360068
NDC80	THRAP3	IntAct, BioGRID	empirical	20360068