CDKN2A

Summary Top Help

Gene Description:

cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Synonyms:

TP16, P16INK4, Cdkn2a, p16, CDKN2, p16Cdkn2a, MTS1, P16, P14ARF, p16(INK4a), CMM2, CDKN2A, Arf, P16INK4A, MLM, ARF, INK4, p16INK4a, p19, P19ARF, ARF-INK4a, INK4a-ARF, Pctr1, P19, INK4A, Ink4a/Arf, P16-INK4A, p19ARF, CDK4I, P14, MTS-1

Orthologs:

Human CDKN2A (protein-coding), Mouse Cdkn2a (protein-coding), Rat Cdkn2a (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr9:21967751..21995300 (27.55 kb) View in Genome Browser

(Mouse) NCBIM37 - chr4:88920377..88940557 (20.18 kb) View in Genome Browser

(Rat) RGSC3.4 - chr5:108908749..108916380 (7.63 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CDKN2A:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CDKN2A:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 9

Biocarta: 4

Reactome: 4

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 59

Cell cycle checkpoint	GO:0000075
G1 phase of mitotic cell cycle	GO:0000080
G1/S transition of mitotic cell cycle	GO:0000082
Protein polyubiquitination	GO:0000209
Mitotic cell cycle	GO:0000278
Negative regulation of cell-matrix adhesion	GO:0001953
P53 binding	GO:0002039
DNA binding	GO:0003677
Cyclin-dependent protein kinase inhibitor activity	GO:0004861
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Cytosol	GO:0005829
DNA fragmentation involved in apoptotic nuclear change	GO:0006309
RRNA processing	GO:0006364
Negative regulation of protein kinase activity	GO:0006469
Induction of apoptosis	GO:0006917
Activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919
Cell cycle	GO:0007049
Cell cycle arrest	GO:0007050
Ras protein signal transduction	GO:0007265
Transcription factor binding	GO:0008134
Negative regulation of cell proliferation	GO:0008285
Apoptotic mitochondrial changes	GO:0008637
Regulation of G2/M transition of mitotic cell cycle	GO:0010389
Nuclear body	GO:0016604
Protein kinase binding	GO:0019901
Negative regulation of cell growth	GO:0030308
Negative regulation of B cell proliferation	GO:0030889
Regulation of protein stability	GO:0031647
Protein destabilization	GO:0031648
Negative regulation of NF-kappaB transcription factor activity	GO:0032088
Negative regulation of immature T cell proliferation in thymus	GO:0033088
Positive regulation of protein sumoylation	GO:0033235
Positive regulation of smooth muscle cell apoptosis	GO:0034393
Senescence-associated heterochromatin focus	GO:0035985
Senescence-associated heterochromatin focus assembly	GO:0035986
Negative regulation of phosphorylation	GO:0042326
Protein complex	GO:0043234
Positive regulation of DNA damage response, signal transduction by p53 class mediator	GO:0043517
Negative regulation of cyclin-dependent protein kinase activity	GO:0045736
Negative regulation of transcription, DNA-dependent	GO:0045892
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Regulation of protein export from nucleus	GO:0046825
Somatic stem cell division	GO:0048103
Protein stabilization	GO:0050821
NF-kappaB binding	GO:0051059
Negative regulation of ubiquitin-protein ligase activity	GO:0051444
Ubiquitin-protein ligase inhibitor activity	GO:0055105
MDM2 binding	GO:0070215
Protein K63-linked ubiquitination	GO:0070534
Positive regulation of cell cycle arrest	GO:0071158
Cellular senescence	GO:0090398
Replicative senescence	GO:0090399
Positive regulation of macrophage apoptosis	GO:2000111
Positive regulation of cellular senescence	GO:2000774

Publications from PubMed Top Help

Type 1 Diabetes Publications: 25

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.
Hribal ML, Presta I, Procopio T, Marini MA, Stančáková A, Kuusisto J, Andreozzi F, Hammarstedt A, Jansson PA, Grarup N, Hansen T, Walker M, Stefan N, Fritsche A, Häring HU, Pedersen O, Smith U, Laakso M, Sesti G, on behalf of the EUGENE2 Consortium
Diabetologia. 2011
PubMed ID: 21234743
Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.
Heni M, Ketterer C, Thamer C, Herzberg-Schäfer SA, Guthoff M, Stefan N, Machicao F, Staiger H, Fritsche A, Häring HU
Diabetes. 2010
PubMed ID: 20802253
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Bragi Walters G, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, MAGIC investigators, GIANT Consortium
Nat Genet. 2010
PubMed ID: 20581827
Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2 and CDKAL1 on the risk of type 2 diabetes in 5164 Indians.
Chauhan G, Spurgeon CJ, Tabassum R, Bhaskar S, Kulkarni SR, Mahajan A, Chavali S, Kumar MV, Prakash S, Dwivedi OP, Ghosh S, Yajnik CS, Tandon N, Bharadwaj D, Chandak GR
Diabetes. 2010
PubMed ID: 20424228
Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
Han X, Luo Y, Ren Q, Zhang X, Wang F, Sun X, Zhou X, Ji L
BMC Med Genet. 2010
PubMed ID: 20509872
Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
Pierce BL, Ahsan H
Hum Hered. 2010
PubMed ID: 20203524
A Combined Risk Allele Score of Eight Type 2 Diabetes Genes Is Associated With Reduced First Phase Glucose Stimulated Insulin Secretion During Hyperglycemic Clamps.
't Hart LM, Simonis-Bik AM, Nijpels G, van Haeften TW, Schäfer SA, Houwing-Duistermaat JJ, Boomsma DI, Groenewoud MJ, Reiling E, van Hove EC, Diamant M, Kramer MH, Heine RJ, Maassen JA, Kirchhoff K, Machicao F, Häring HU, Slagboom PE, Willemsen G, Eekhoff EM, de Geus EJ, Dekker JM, Fritsche A
Diabetes. 2009
PubMed ID: 19808892
Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS).
Kelliny C, Ekelund U, Bo Andersen L, Brage S, Loos RJ, Wareham NJ, Langenberg C
Diabetes. 2009
PubMed ID: 19741166
Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewsky B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L
PLoS Genet. 2009
PubMed ID: 19629168
Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.
Chen H, Gu X, Su IH, Bottino R, Contreras JL, Tarakhovsky A, Kim SK
Genes Dev. 2009
PubMed ID: 19390090
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.
Dhawan S, Tschen SI, Bhushan A
Genes Dev. 2009
PubMed ID: 19390085
The inhibitory association of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity.
Haupt A, Guthoff M, Schäfer SA, Kirchhoff K, Machicao F, Gallwitz B, Staiger H, Stefan N, Fritsche A, Häring HU
J Clin Endocrinol Metab. 2009
PubMed ID: 19258404
Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia.
Seeley ES, Carrière C, Goetze T, Longnecker DS, Korc M
Cancer Res. 2009
PubMed ID: 19147554
Clinical risk factors, DNA variants, and the development of type 2 diabetes.
Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, Berglund G, Altshuler D, Nilsson P, Groop L
N Engl J Med. 2008
PubMed ID: 19020324
Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles.
Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M, on behalf of the RISC Consortium
Diabetologia. 2008
PubMed ID: 18719881
Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8 and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
Wu Y, Li H, Loos RJ, Yu Z, Ye X, Chen L, Pan A, Hu FB, Lin X
Diabetes. 2008
PubMed ID: 18633108
EXTENSION OF TYPE 2 DIABETES GENOME-WIDE ASSOCIATION SCAN RESULTS IN THE DIABETES PREVENTION PROGRAM.
Moore AF, Jablonski KA, McAteer JB, Saxena R, Pollin TI, Franks PW, Hanson RL, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, For The Diabetes Prevention Program Research Group
Diabetes. 2008
PubMed ID: 18544707
Mechanisms of disease: genetic insights into the etiology of type 2 diabetes and obesity.
Lindgren CM, McCarthy MI
Nat Clin Pract Endocrinol Metab. 2008
PubMed ID: 18212765
Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.
Grarup N, Rose CS, Andersson EA, Andersen G, Nielsen AL, Albrechtsen A, Clausen JO, Rasmussen SS, Jørgensen T, Sandbaek A, Lauritzen T, Schmitz O, Hansen T, Pedersen O
Diabetes. 2007
PubMed ID: 17827400
Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function.
Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M, RISC Consortium, U.K. Type 2 Diabetes Genetics Consortium
Diabetes. 2007
PubMed ID: 17804762
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Wellcome Trust Case Control Consortium
Nature. 2007
PubMed ID: 17554300
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT
Science. 2007
PubMed ID: 17463249
Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE
Cancer Res. 2007
PubMed ID: 17510401
p16INK4a induces an age-dependent decline in islet regenerative potential.
Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE
Nature. 2006
PubMed ID: 16957737
Epigenetic and genetic analysis of p16 in dermal fibroblasts from type 1 diabetic patients with nephropathy.
Zeng L, Kanwar YS, Amro N, Phillips C, Molitch M, Batlle D, Danesh FR
Kidney Int. 2003
PubMed ID: 12753296

Publications: 1841

KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ
Cancer Cell. 2012
PubMed ID: 22264792
Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence.
Gagrica S, Brookes S, Anderton E, Rowe J, Peters G
Cancer Res. 2012
PubMed ID: 22080569
Hypergrowth mTORC1 signals translationally activate the ARF tumor suppressor checkpoint.
Miceli AP, Saporita AJ, Weber JD
Mol Cell Biol. 2012
PubMed ID: 22064482
INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury.
Lee DH, Wolstein JM, Pudasaini B, Plotkin M
Am J Physiol Renal Physiol. 2012
PubMed ID: 21957175
The tumor suppressor ARF regulates innate immune responses in mice.
Través PG, López-Fontal R, Luque A, Hortelano S
J Immunol. 2011
PubMed ID: 22095712
PAX3-FOXO1 induces cannabinoid receptor 1 to enhance cell invasion and metastasis.
Marshall AD, Lagutina I, Grosveld GC
Cancer Res. 2011
PubMed ID: 22037868
Implications of continued upregulation of p16(INK4a) through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervix.
Cheah PL, Looi LM, Mun KS, Abdoul Rahman N, Teoh KH
Malays J Pathol. 2011
PubMed ID: 22299207
Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.
Acquaviva J, Jun HJ, Lessard J, Ruiz R, Zhu H, Donovan M, Woolfenden S, Boskovitz A, Raval A, Bronson RT, Pfannl R, Whittaker CA, Housman DE, Charest A
Cancer Res. 2011
PubMed ID: 21987724
Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.
Chokkalingam AP, Bartley K, Wiemels JL, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Chang JS, Month SR, Wiencke JK, Buffler PA
Cancer Causes Control. 2011
PubMed ID: 21987080
Abnormal MDMX degradation in tumor cells due to ARF deficiency.
Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J
Oncogene. 2011
PubMed ID: 22120712
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L
Nature. 2011
PubMed ID: 22080947
EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction.
Jin X, Yin J, Kim SH, Sohn YW, Beck S, Lim YC, Nam DH, Choi YJ, Kim H
Cancer Res. 2011
PubMed ID: 21975932
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM
Nature. 2011
PubMed ID: 22048312
Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y
J Proteome Res. 2011
PubMed ID: 21942715
Association of p16(INK4a) overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue.
Harris SL, Thorne LB, Seaman WT, Hayes DN, Couch ME, Kimple RJ
Head Neck. 2011
PubMed ID: 21990227
Diagnostic implications of L1, p16, and Ki-67 proteins and HPV DNA in low-grade cervical intraepithelial neoplasia.
Gatta LB, Berenzi A, Balzarini P, Dessy E, Angiero F, Alessandri G, Gambino A, Grigolato P, Benetti A
Int J Gynecol Pathol. 2011
PubMed ID: 21979598
RNA helicase DDX5 is a p53-independent target of ARF that participates in ribosome biogenesis.
Saporita AJ, Chang HC, Winkeler CL, Apicelli AJ, Kladney RD, Wang J, Townsend RR, Michel LS, Weber JD
Cancer Res. 2011
PubMed ID: 21937682
Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.
Kuo CL, Murphy AJ, Sayers S, Li R, Yvan-Charvet L, Davis JZ, Krishnamurthy J, Liu Y, Puig O, Sharpless NE, Tall AR, Welch CL
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21868699
Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation.
Park SH, Lim JS, Lim SY, Tiwari I, Jang KL
Cancer Lett. 2011
PubMed ID: 21757290
DNA copy number profile discriminates between esophageal adenocarcinoma and squamous cell carcinoma and represents an independent prognostic parameter in esophageal adenocarcinoma.
Rumiato E, Pasello G, Montagna M, Scaini MC, De Salvo GL, Parenti A, Cagol M, Ruol A, Ancona E, Amadori A, Saggioro D
Cancer Lett. 2011
PubMed ID: 21757289
Methylation status of the gene promoter of cyclin-dependent kinase inhibitor 2A (CDKN2A) in ovarian cancer.
Abou-Zeid AA, Azzam AZ, Kamel NA
Scand J Clin Lab Invest. 2011
PubMed ID: 21728901
ARF triggers cell G1 arrest by a P53 independent ERK pathway.
Du H, Yao W, Fang M, Wu D
Mol Cell Biochem. 2011
PubMed ID: 21660463
Expression of p16 in non-small cell lung cancer and its prognostic significance: a meta-analysis of published literatures.
Tong J, Sun X, Cheng H, Zhao D, Ma J, Zhen Q, Cao Y, Zhu H, Bai J
Lung Cancer. 2011
PubMed ID: 21621871
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.
Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J
J Biol Chem. 2011
PubMed ID: 21880712
Joint associations between genetic variants and reproductive factors in glioma risk among women.
Wang SS, Hartge P, Yeager M, Carreón T, Ruder AM, Linet M, Inskip PD, Black A, Hsing AW, Alavanja M, Beane-Freeman L, Safaiean M, Chanock SJ, Rajaraman P
Am J Epidemiol. 2011
PubMed ID: 21920947
The tumor suppressor p33ING1b upregulates p16INK4a expression and induces cellular senescence.
Li N, Li Q, Cao X, Zhao G, Xue L, Tong T
FEBS Lett. 2011
PubMed ID: 21896275
A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas.
Sterlacci W, Tzankov A, Veits L, Zelger B, Bihl MP, Foerster A, Augustin F, Fiegl M, Savic S
J Thorac Oncol. 2011
PubMed ID: 21857254
The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathway.
Feng Z, Chen J, Wei H, Gao P, Shi J, Zhang J, Zhao F
Exp Mol Pathol. 2011
PubMed ID: 21777578
Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
Shaikhibrahim Z, Lindstrot A, Buettner R, Wernert N
Int J Mol Med. 2011
PubMed ID: 21743959
RB1CC1 activates the p16 promoter through the interaction with hSNF5.
Ochi Y, Chano T, Ikebuchi K, Inoue H, Isono T, Arai A, Tameno H, Shimada T, Hisa Y, Okabe H
Oncol Rep. 2011
PubMed ID: 21637919
Role for p16(INK4a) in progression of gastrointestinal stromal tumors of the stomach: alteration of p16(INK4a) network members.
Mitomi H, Fukui N, Kishimoto I, Tanabe S, Kikuchi S, Saito T, Hayashi T, Yao T
Hum Pathol. 2011
PubMed ID: 21496871
The emerging role of Mule and ARF in the regulation of base excision repair.
Khoronenkova SV, Dianov GL
FEBS Lett. 2011
PubMed ID: 21726556
Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function.
Pimkina J, Murphy ME
Cancer Biol Ther. 2011
PubMed ID: 21738007
Analysis of p53, p16(INK4a), pRb and Cyclin D1 expression and human papillomavirus in primary ovarian serous carcinomas.
Bilyk OO, Pande NT, Buchynska LG
Exp Oncol. 2011
PubMed ID: 21956468
[Expression of the tumormarker p16INK4a in cytology specimens of the urinary bladder. A new means for early recognition and surveillance of urothelial cancer].
Tauber S, Brunken C, Vierbuchen M
Urologe A. 2011
PubMed ID: 21847682
High-risk human papillomavirus E6/E7 mRNA detection by a novel in situ hybridization assay strongly correlates with p16 expression and patient outcomes in oropharyngeal squamous cell carcinoma.
Ukpo OC, Flanagan JJ, Ma XJ, Luo Y, Thorstad WL, Lewis JS
Am J Surg Pathol. 2011
PubMed ID: 21836494
Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through down-regulation of p19ARF.
Nishimoto N, Arai S, Ichikawa M, Nakagawa M, Goyama S, Kumano K, Takahashi T, Kamikubo Y, Imai Y, Kurokawa M
Blood. 2011
PubMed ID: 21757616
MicroRNA-146a inhibits glioma development by targeting Notch1.
Mei J, Bachoo R, Zhang CL
Mol Cell Biol. 2011
PubMed ID: 21730286
Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients.
Löf-Öhlin ZM, Sorbe B, Wingren S, Nilsson TK
Int J Oncol. 2011
PubMed ID: 21674126
Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas.
Guney S, Bertrand P, Jardin F, Ruminy P, Kerckaert JP, Tilly H, Bastard C
Genes Chromosomes Cancer. 2011
PubMed ID: 21638516
p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.
Cudejko C, Wouters K, Fuentes L, Hannou SA, Paquet C, Bantubungi K, Bouchaert E, Vanhoutte J, Fleury S, Remy P, Tailleux A, Chinetti-Gbaguidi G, Dombrowicz D, Staels B, Paumelle R
Blood. 2011
PubMed ID: 21636855
Aberrant expression of p53, p16INK4a and Ki-67 as basic biomarker for malignant progression of oral leukoplakias.
Nasser W, Flechtenmacher C, Holzinger D, Hofele C, Bosch FX
J Oral Pathol Med. 2011
PubMed ID: 21435003
Prognostic significance of p16INK4a/p53 in Tunisian patients with breast carcinoma.
Karray-Chouayekh S, Baccouche S, Khabir A, Sellami-Boudawara T, Daoud J, Frikha M, Jlidi R, Gargouri A, Mokdad-Gargouri R
Acta Histochem. 2011
PubMed ID: 20598349
Jarid2 regulates mouse epidermal stem cell activation and differentiation.
Mejetta S, Morey L, Pascual G, Kuebler B, Mysliwiec MR, Lee Y, Shiekhattar R, Di Croce L, Benitah SA
EMBO J. 2011
PubMed ID: 21811233
Ginsenoside Rb1, Rg1 and three extracts of traditional Chinese medicine attenuate ultraviolet B-induced G1 growth arrest in HaCaT cells and dermal fibroblasts involve down-regulating the expression of p16, p21 and p53.
Wang XY, Wang YG, Wang YF
Photodermatol Photoimmunol Photomed. 2011
PubMed ID: 21729169
Interleukin-1α mediates the antiproliferative effects of 1,25-dihydroxyvitamin D3 in prostate progenitor/stem cells.
Maund SL, Barclay WW, Hover LD, Axanova LS, Sui G, Hipp JD, Fleet JC, Thorburn A, Cramer SD
Cancer Res. 2011
PubMed ID: 21653679
p16 expression: a marker of differentiation between childhood malignant melanomas and Spitz nevi.
Al Dhaybi R, Agoumi M, Gagné I, McCuaig C, Powell J, Kokta V
J Am Acad Dermatol. 2011
PubMed ID: 21550132
OVCA1 inhibits the proliferation of epithelial ovarian cancer cells by decreasing cyclin D1 and increasing p16.
Kong F, Tong R, Jia L, Wei W, Miao X, Zhao X, Sun W, Yang G, Zhao C
Mol Cell Biochem. 2011
PubMed ID: 21487939
A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia.
Iacobucci I, Sazzini M, Garagnani P, Ferrari A, Boattini A, Lonetti A, Papayannidis C, Mantovani V, Marasco E, Ottaviani E, Soverini S, Girelli D, Luiselli D, Vignetti M, Baccarani M, Martinelli G
Leuk Res. 2011
PubMed ID: 21414664
Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma.
Miladi-Abdennadher I, Abdelmaksoud-Damak R, Ayadi L, Khabir A, Frikha F, Kallel L, Frikha M, Sellami-Boudawara T, Gargouri A, Mokdad-Gargouri R
Biosci Rep. 2011
PubMed ID: 20815811
Loss of p19Arf in a Rag1(-/-) B-cell precursor population initiates acute B-lymphoblastic leukemia.
Hauer J, Mullighan C, Morillon E, Wang G, Bruneau J, Brousse N, Lelorc'h M, Romana S, Boudil A, Tiedau D, Kracker S, Bushmann FD, Borkhardt A, Fischer A, Hacein-Bey-Abina S, Cavazzana-Calvo M
Blood. 2011
PubMed ID: 21622646
P16 gene hypermethylation and hepatocellular carcinoma: a systematic review and meta-analysis.
Zang JJ, Xie F, Xu JF, Qin YY, Shen RX, Yang JM, He J
World J Gastroenterol. 2011
PubMed ID: 21799651
E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.
Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L
J Exp Med. 2011
PubMed ID: 21708927
Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells.
Churchman ML, Roig I, Jasin M, Keeney S, Sherr CJ
PLoS Genet. 2011
PubMed ID: 21811412
Aberrant protein expression and promoter methylation of p16 gene are correlated with malignant transformation of salivary pleomorphic adenoma.
Hu YH, Zhang CY, Tian Z, Wang LZ, Li J
Arch Pathol Lab Med. 2011
PubMed ID: 21732778
Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype.
Wiesner SM, Geurts JL, Diers MD, Bergerson RJ, Hasz DE, Morgan KJ, Largaespada DA
Am J Hematol. 2011
PubMed ID: 21681782
Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes.
Falbo V, Floridia G, Censi F, Marra M, Foschini MP, Taruscio D
Oncol Rep. 2011
PubMed ID: 21503581
Loss of heterozygosity of tumor suppressor genes (p16, Rb, E-cadherin, p53) in hypopharynx squamous cell carcinoma.
Sang-Hyuk Lee SH, Lee NH, Jin SM, Rho YS, Jo SJ
Otolaryngol Head Neck Surg. 2011
PubMed ID: 21493295
p19(ARF) /p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma.
Schneller D, Machat G, Sousek A, Proell V, van Zijl F, Zulehner G, Huber H, Mair M, Muellner MK, Nijman SM, Eferl R, Moriggl R, Mikulits W
Hepatology. 2011
PubMed ID: 21452288
Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.
Kriegl L, Neumann J, Vieth M, Greten FR, Reu S, Jung A, Kirchner T
Mod Pathol. 2011
PubMed ID: 21423154
Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.
Li J, Poi MJ, Tsai MD
Biochemistry. 2011
PubMed ID: 21619050
SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity.
Rivera LB, Brekken RA
J Cell Biol. 2011
PubMed ID: 21708981
Performance of p16INK4a immunocytochemistry as a marker of anal squamous intraepithelial lesions.
Tramujas da Costa E Silva I, Coelho Ribeiro M, Santos Gimenez F, Dutra Ferreira JR, Galvao RS, Vasco Hargreaves PE, Gonçalves Daumas Pinheiro Guimaraes A, de Lima Ferreira LC
Cancer Cytopathol. 2011
PubMed ID: 21365778
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway.
Martinelli P, Bonetti P, Sironi C, Pruneri G, Fumagalli C, Raviele PR, Volorio S, Pileri S, Chiarle R, McDuff FK, Tusi BK, Turner SD, Inghirami G, Pelicci PG, Colombo E
Blood. 2011
PubMed ID: 21518927
PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia.
Kim M, Choi JE, She CJ, Hwang SM, Shin HY, Ahn HS, Yoon SS, Kim BK, Park MH, Lee DS
Blood Cells Mol Dis. 2011
PubMed ID: 21549623
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Guerra C, Collado M, Navas C, Schuhmacher AJ, Hernández-Porras I, Cañamero M, Rodriguez-Justo M, Serrano M, Barbacid M
Cancer Cell. 2011
PubMed ID: 21665147
BRAF activation induces transformation and then senescence in human neural stem cells: a pilocytic astrocytoma model.
Raabe EH, Lim KS, Kim JM, Meeker A, Mao XG, Nikkhah G, Maciaczyk J, Kahlert U, Jain D, Bar E, Cohen KJ, Eberhart CG
Clin Cancer Res. 2011
PubMed ID: 21636552
EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.
Geddert H, zur Hausen A, Gabbert HE, Sarbia M
Cell Oncol (Dordr). 2011
PubMed ID: 21538028
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
Young NP, Crowley D, Jacks T
Cancer Res. 2011
PubMed ID: 21512139
Melanoma candidate genes CDKN2A/p16/INK4A, p14ARF, and CDK4 sequencing in patients with uveal melanoma with relative high-risk for hereditary cancer predisposition.
Abdel-Rahman MH, Pilarski R, Massengill JB, Christopher BN, Noss R, Davidorf FH
Melanoma Res. 2011
PubMed ID: 21412176
Hepatitis B virus X protein overcomes all-trans retinoic acid-induced cellular senescence by downregulating levels of p16 and p21 via DNA methylation.
Park SH, Jung JK, Lim JS, Tiwari I, Jang KL
J Gen Virol. 2011
PubMed ID: 21325480
Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors.
Endo M, Kobayashi C, Setsu N, Takahashi Y, Kohashi K, Yamamoto H, Tamiya S, Matsuda S, Iwamoto Y, Tsuneyoshi M, Oda Y
Clin Cancer Res. 2011
PubMed ID: 21262917
Aberrant cytoplasmic expression of cyclin B1 protein and its correlation with EBV-LMP1, P53 and P16(INK4A) in classical Hodgkin lymphoma in China.
Zhao P, Lu Y, Liu L, Zhong M
Pathol Oncol Res. 2011
PubMed ID: 21174181
Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats.
Zheng S, Pan YX
J Nutr Biochem. 2011
PubMed ID: 20934317
Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis.
Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, Moreno de Alborán I, Pillai MR, Eswaran J, Kumar R
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21555589
Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies.
Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP
Blood. 2011
PubMed ID: 21427293
Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes.
Kalamarides M, Stemmer-Rachamimov AO, Niwa-Kawakita M, Chareyre F, Taranchon E, Han ZY, Martinelli C, Lusis EA, Hegedus B, Gutmann DH, Giovannini M
Oncogene. 2011
PubMed ID: 21242963
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
Sanson M, Hosking FJ, Shete S, Zelenika D, Dobbins SE, Ma Y, Enciso-Mora V, Idbaih A, Delattre JY, Hoang-Xuan K, Marie Y, Boisselier B, Carpentier C, Wang XW, Di Stefano AL, Labussière M, Gousias K, Schramm J, Boland A, Lechner D, Gut I, Armstrong G, Liu Y, Yu R, Lau C, Di Bernardo MC, Robertson LB, Muir K, Hepworth S, Swerdlow A, Schoemaker MJ, Wichmann HE, Müller M, Schreiber S, Franke A, Moebus S, Eisele L, Försti A, Hemminki K, Lathrop M, Bondy M, Houlston RS, Simon M
Hum Mol Genet. 2011
PubMed ID: 21531791
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
Parra EJ, Below JE, Krithika S, Valladares A, Barta JL, Cox NJ, Hanis CL, Wacher N, Garcia-Mena J, Hu P, Shriver MD, Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium, Kumate J, McKeigue PM, Escobedo J, Cruz M
Diabetologia. 2011
PubMed ID: 21573907
p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors.
Romagosa C, Simonetti S, López-Vicente L, Mazo A, Lleonart ME, Castellvi J, Ramon y Cajal S
Oncogene. 2011
PubMed ID: 21297668
Helicobacter pylori upregulates the expression of p16(INK4) in gastric cancer cells.
Wang P, Mei J, Zhang N, Tao J, Tian H, Fu GH
Hepatogastroenterology. 2011
PubMed ID: 21830402
p16INK4a methylation in serum as a follow-up marker for recurrence of colorectal cancer.
Nakayama G, Kodera Y, Ohashi N, Koike M, Fujiwara M, Nakao A
Anticancer Res. 2011
PubMed ID: 21617221
Overexpressions of Cyclin B1, cdc2, p16 and p53 in human breast cancer: the clinicopathologic correlations and prognostic implications.
Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS, Kim JH
Yonsei Med J. 2011
PubMed ID: 21488187
Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in ovarian epithelial tumors.
Lee YH, Heo JH, Kim TH, Kang H, Kim G, Kim J, Cho SH, An HJ
Int J Gynecol Pathol. 2011
PubMed ID: 21464733
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.
Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, Citterio E, van Lohuizen M, Ganesan S
Mol Cell Biol. 2011
PubMed ID: 21383063
Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway.
Chien WW, Domenech C, Catallo R, Kaddar T, Magaud JP, Salles G, Ffrench M
Oncogene. 2011
PubMed ID: 21170085
Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells.
Juan AH, Derfoul A, Feng X, Ryall JG, Dell'Orso S, Pasut A, Zare H, Simone JM, Rudnicki MA, Sartorelli V
Genes Dev. 2011
PubMed ID: 21498568
Identification of loss of p16 expression and upregulation of MDR-1 as genetic events resulting from two novel chromosomal translocations found in a plasmablastic lymphoma of the uterus.
Matsuki E, Miyakawa Y, Asakawa S, Tsukada Y, Yamada T, Yokoyama K, Kudoh J, Ikeda Y, Okamoto S
Clin Cancer Res. 2011
PubMed ID: 21325069
VentX trans-activates p53 and p16ink4a to regulate cellular senescence.
Wu X, Gao H, Ke W, Hager M, Xiao S, Freeman MR, Zhu Z
J Biol Chem. 2011
PubMed ID: 21325273
Methylation of RAR-β2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats.
Zhang J, Zhang J, Li M, Wu Y, Fan Y, Zhou Y, Tan L, Shao Z, Shi H
Biomed Environ Sci. 2011
PubMed ID: 21565688
A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW
Cell. 2011
PubMed ID: 21458673
P16 methylation is an early event in cervical carcinogenesis.
Huang LW, Pan HS, Lin YH, Seow KM, Chen HJ, Hwang JL
Int J Gynecol Cancer. 2011
PubMed ID: 21436693
Overexpression of cdk4 and p16 in oral lichen planus supports the concept of premalignancy.
Poomsawat S, Buajeeb W, Khovidhunkit SO, Punyasingh J
J Oral Pathol Med. 2011
PubMed ID: 21426400
The diagnostic utility of p16 FISH and GLUT-1 immunohistochemical analysis in mesothelial proliferations.
Monaco SE, Shuai Y, Bansal M, Krasinskas AM, Dacic S
Am J Clin Pathol. 2011
PubMed ID: 21411785
Simultaneous aberrations of single CDKN2A network components and a high Rb phosphorylation status can differentiate subgroups of primary cutaneous B-cell lymphomas.
Kaune KM, Neumann C, Hallermann C, Haller F, Schön MP, Middel P
Exp Dermatol. 2011
PubMed ID: 21410763
Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.
Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M
Eur J Immunol. 2011
PubMed ID: 21400497
Melanoma risk for CDKN2A mutation carriers who are relatives of population-based case carriers in Australia and the UK.
Cust AE, Harland M, Makalic E, Schmidt D, Dowty JG, Aitken JF, Agha-Hamilton C, Armstrong BK, Barrett JH, Chan M, Chang YM, Gascoyne J, Giles GG, Holland EA, Kefford RF, Kukalizch K, Lowery J, Randerson-Moor JA, Schmid H, Taylor CF, Whitaker L, Hopper JL, Newton-Bishop JA, Mann GJ, Bishop DT, Jenkins MA
J Med Genet. 2011
PubMed ID: 21325014
Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice.
Cardenas JC, Owens AP, Krishnamurthy J, Sharpless NE, Whinna HC, Church FC
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21233453
Heterogeneous activation of p19Arf in pulmonary artery smooth muscle cells.
Solodushko V, Alvarez DF, Viator R, Messerall T, Fouty B
Am J Physiol Lung Cell Mol Physiol. 2011
PubMed ID: 21216978
Prevalence of CDKN2A mutations in pancreatic cancer patients: implications for genetic counseling.
McWilliams RR, Wieben ED, Rabe KG, Pedersen KS, Wu Y, Sicotte H, Petersen GM
Eur J Hum Genet. 2011
PubMed ID: 21150883
Cell-dependent kinase inhibitor 2A and 2B genetic variability in patients with Alzheimer's disease.
Cortini F, Fenoglio C, Venturelli E, Villa C, Clerici F, Serpente M, Cantoni C, Fumagalli G, Mariani C, Bresolin N, Scarpini E, Galimberti D
J Neurol. 2011
PubMed ID: 21069533
Quantitative evaluation of p16(INK4a) promoter methylation using pyrosequencing in de novo diffuse large B-cell lymphoma.
Zainuddin N, Kanduri M, Berglund M, Lindell M, Amini RM, Roos G, Sundström C, Enblad G, Rosenquist R
Leuk Res. 2011
PubMed ID: 21035853
Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Boulos N, Mulder HL, Calabrese CR, Morrison JB, Rehg JE, Relling MV, Sherr CJ, Williams RT
Blood. 2011
PubMed ID: 21263154
Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes.
Liu Y, Johnson SM, Fedoriw Y, Rogers AB, Yuan H, Krishnamurthy J, Sharpless NE
Blood. 2011
PubMed ID: 21245485
Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo.
Robinson JP, Vanbrocklin MW, Lastwika KJ, McKinney AJ, Brandner S, Holmen SL
Oncogene. 2011
PubMed ID: 21057530
p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.
Zhang Y, Sturgis EM, Zafereo ME, Wei Q, Li G
Cancer. 2011
PubMed ID: 21381012
Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.
Konecny GE, Winterhoff B, Kolarova T, Qi J, Manivong K, Dering J, Yang G, Chalukya M, Wang HJ, Anderson L, Kalli KR, Finn RS, Ginther C, Jones S, Velculescu VE, Riehle D, Cliby WA, Randolph S, Koehler M, Hartmann LC, Slamon DJ
Clin Cancer Res. 2011
PubMed ID: 21278246
HMGA2 and p14Arf: major roles in cellular senescence of fibroids and therapeutic implications.
Markowski DN, Helmke BM, Belge G, Nimzyk R, Bartnitzke S, Deichert U, Bullerdiek J
Anticancer Res. 2011
PubMed ID: 21498692
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans.
Liu KW, Feng H, Bachoo R, Kazlauskas A, Smith EM, Symes K, Hamilton RL, Nagane M, Nishikawa R, Hu B, Cheng SY
J Clin Invest. 2011
PubMed ID: 21393858
Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: a morphologic and immunohistochemical study.
Thway K, Robertson D, Thway Y, Fisher C
Am J Surg Pathol. 2011
PubMed ID: 21317707
The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation.
Al-Khalaf HH, Hendrayani SF, Aboussekhra A
Mol Cancer Res. 2011
PubMed ID: 21270107
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
Fukuda T, Tokunaga A, Sakamoto R, Yoshida N
Mol Cell Neurosci. 2011
PubMed ID: 21220025
p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation.
Lee MO, Lee HJ, Kim MA, Kim EK, Lee JH, Heo JH, Lee SH, Cho SH, Fornace AJ, Jeong HC, Cha HJ
J Thorac Oncol. 2011
PubMed ID: 21164364
p14(ARF) inhibits the functions of adenovirus E1A oncoprotein.
Shen J, Zhang S, Li Y, Zhang W, Chen J, Zhang M, Wang T, Jiang L, Zou X, Wong J, Li X, Cui Y, Wang C
Biochem J. 2011
PubMed ID: 21133853
Magnetic resonance imaging surveillance detects early-stage pancreatic cancer in carriers of a p16-Leiden mutation.
Vasen HF, Wasser M, van Mil A, Tollenaar RA, Konstantinovski M, Gruis NA, Bergman W, Hes FJ, Hommes DW, Offerhaus GJ, Morreau H, Bonsing BA, de Vos tot Nederveen Cappel WH
Gastroenterology. 2011
PubMed ID: 21129377
The RB (pRb2/p16) and p53 (p14/p53/p21) tumor-suppressor pathways in endemic Burkitt lymphoma.
Kalungi S, Wabinga H, Bostad L
J Pediatr Hematol Oncol. 2011
PubMed ID: 21127431
Prognostic significance of CDKN2A (p16) promoter methylation and loss of expression in 902 colorectal cancers: Cohort study and literature review.
Shima K, Nosho K, Baba Y, Cantor M, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S
Int J Cancer. 2011
PubMed ID: 20473920
Expression of p16 protein and epidermal growth factor receptor in patients with adenocarcinoma of the uterine cervix: an immunohistochemical analysis.
Bodner K, Laubichler P, Kimberger O, Czerwenka K, Zeillinger R, Bodner-Adler B
Arch Gynecol Obstet. 2011
PubMed ID: 20405295
Overexpression of c-erbB-2 and loss of p16 have molecular diagnostic relevance but no prognostic value in lung cancer.
Feng XL, Li L, Gao YN, Zhang JJ, Xiao T, Ying JM, Gao JD, Sun YT, Cheng SJ
Med Oncol. 2011
PubMed ID: 20237870
p16 INK4A positivity identifies endometrial surface papillary syncitial change as a regressive feature associated with desquamation.
Nicolae A, Preda O, Aneiros-Fernández J, Palacios J, Biscuola M, Nogales FF
Histopathology. 2011
PubMed ID: 21323964
The retinoblastoma protein/p16 INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma.
Stankiewicz E, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Kudahetti S, Watkin N, Corbishley C, Berney DM
Histopathology. 2011
PubMed ID: 21323963
[Relationship between promoter methylation of p16, DAPK and RAR beta genes and the clinical data of non-small cell lung cancer].
Zhang CY, Jin YT, Xu HY, Zhang H, Zhang WM, Sun XY, Tan C, Chen CM
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011
PubMed ID: 21287504
Value of p16(INK)⁴(a) in the pathology of invasive penile squamous cell carcinomas: A report of 202 cases.
Cubilla AL, Lloveras B, Alejo M, Clavero O, Chaux A, Kasamatsu E, Monfulleda N, Tous S, Alemany L, Klaustermeier J, Muñoz N, Quint W, de Sanjose S, Bosch FX
Am J Surg Pathol. 2011
PubMed ID: 21263246
CREG1 enhances p16(INK4a) -induced cellular senescence.
Moolmuang B, Tainsky MA
Cell Cycle. 2011
PubMed ID: 21263217
Epstein-Barr virus nuclear antigens 3C and 3A maintain lymphoblastoid cell growth by repressing p16INK4A and p14ARF expression.
Maruo S, Zhao B, Johannsen E, Kieff E, Zou J, Takada K
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21245331
NKX2.2 suppresses self-renewal of glioma-initiating cells.
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
Cancer Res. 2011
PubMed ID: 21169405
Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas.
Poetsch M, Hemmerich M, Kakies C, Kleist B, Wolf E, vom Dorp F, Hakenberg OW, Protzel C
Virchows Arch. 2011
PubMed ID: 21085986
Immunohistochemical expression of retinoblastoma protein and p16 in renal cell carcinoma.
Maruschke M, Thur S, Kundt G, Nizze H, Hakenberg OW
Urol Int. 2011
PubMed ID: 20861610
Prognostic significance of the alterations of the G1-S checkpoint in localized leiomyosarcoma of the peripheral soft tissue.
Panelos J, Beltrami G, Scoccianti G, Capanna R, Paglierani M, Pepi M, Massi D, Franchi A
Ann Surg Oncol. 2011
PubMed ID: 20680693
Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque.
Holdt LM, Sass K, Gäbel G, Bergert H, Thiery J, Teupser D
Atherosclerosis. 2011
PubMed ID: 20637465
The p16(INK4A) tumor suppressor regulates cellular oxidative stress.
Jenkins NC, Liu T, Cassidy P, Leachman SA, Boucher KM, Goodson AG, Samadashwily G, Grossman D
Oncogene. 2011
PubMed ID: 20838381
Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12.
Põlajeva J, Sjösten AM, Lager N, Kastemar M, Waern I, Alafuzoff I, Smits A, Westermark B, Pejler G, Uhrbom L, Tchougounova E
PLoS One. 2011
PubMed ID: 21949886
Promoter methylation of E-cadherin, p16, and RAR-β(2) genes in breast tumors and dietary intake of nutrients important in one-carbon metabolism.
Tao MH, Mason JB, Marian C, McCann SE, Platek ME, Millen A, Ambrosone C, Edge SB, Krishnan SS, Trevisan M, Shields PG, Freudenheim JL
Nutr Cancer. 2011
PubMed ID: 21916701
p53 and p16(INK4A) independent induction of senescence by chromatin-dependent alteration of S-phase progression.
Prieur A, Besnard E, Babled A, Lemaitre JM
Nat Commun. 2011
PubMed ID: 21915115
Inactivation of COX-2, HMLH1 and CDKN2A gene by promoter methylation in gastric cancer: relationship with histological subtype, tumor location and Helicobacter pylori genotype.
Alves MK, Ferrasi AC, Lima VP, Ferreira MV, de Moura Campos Pardini MI, Rabenhorst SH
Pathobiology. 2011
PubMed ID: 21849808
Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas.
Liu W, Lv G, Li Y, Li L, Wang B
J Exp Clin Cancer Res. 2011
PubMed ID: 21843312
Disrupted lymph node and splenic stroma in mice with induced inflammatory melanomas is associated with impaired recruitment of T and dendritic cells.
Soudja SM, Henri S, Mello M, Chasson L, Mas A, Wehbe M, Auphan-Anezin N, Leserman L, Van den Eynde B, Schmitt-Verhulst AM
PLoS One. 2011
PubMed ID: 21811640
p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.
Al-Khalaf HH, Colak D, Al-Saif M, Al-Bakheet A, Hendrayani SF, Al-Yousef N, Kaya N, Khabar KS, Aboussekhra A
PLoS One. 2011
PubMed ID: 21799732
P16 and retinoblastoma protein expression in endometrial carcinoma and clinical significance.
Koh VM, Shi YX, Tang QH
Eur J Gynaecol Oncol. 2011
PubMed ID: 21797124
Dysregulated ΔNp63α inhibits expression of Ink4a/arf, blocks senescence, and promotes malignant conversion of keratinocytes.
Ha L, Ponnamperuma RM, Jay S, Ricci MS, Weinberg WC
PLoS One. 2011
PubMed ID: 21789189
Frequent upregulation of cyclin D1 and p16 expression with low Ki-67 scores in multinucleated giant cells.
Choi JW, Lee JH, Kim YS
Pathobiology. 2011
PubMed ID: 21778791
Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression.
Fomchenko EI, Dougherty JD, Helmy KY, Katz AM, Pietras A, Brennan C, Huse JT, Milosevic A, Holland EC
PLoS One. 2011
PubMed ID: 21754979
The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression.
Pan W, Issaq S, Zhang Y
PLoS One. 2011
PubMed ID: 21747916
Promoter methylation of p16(INK4A), hMLH1, and MGMT in liquid-based cervical cytology samples compared with clinicopathological findings and HPV presence.
Spathis A, Aga E, Alepaki M, Chranioti A, Meristoudis C, Panayiotides I, Kassanos D, Karakitsos P
Infect Dis Obstet Gynecol. 2011
PubMed ID: 21747645
Decreased D2-40 and increased p16INK4A immunoreactivities correlate with higher grade of cervical intraepithelial neoplasia.
Han H, Yang Y, Lu Z, He Q, Lin Z
Diagn Pathol. 2011
PubMed ID: 21729305
Mitotic arrest in teratoma susceptible fetal male germ cells.
Western PS, Ralli RA, Wakeling SI, Lo C, van den Bergen JA, Miles DC, Sinclair AH
PLoS One. 2011
PubMed ID: 21674058
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways.
Wang Z, Banerjee S, Ahmad A, Li Y, Azmi AS, Gunn JR, Kong D, Bao B, Ali S, Gao J, Mohammad RM, Miele L, Korc M, Sarkar FH
PLoS One. 2011
PubMed ID: 21673986
P16, c-erbB2 and Ki67 immunoexpression in urothelial carcinomas of the bladder.
Stepan A, Simionescu C, Mărgăritescu C, Ciurea R
Rom J Morphol Embryol. 2011
PubMed ID: 21655657
High p16 expression predicts a positive response to chemoradiotherapy in stage IVa/b head and neck squamous cell carcinoma.
Chen YJ, Rau KM, Chien CY, Fang FM, Huang TL, Chiu TJ
Asian Pac J Cancer Prev. 2011
PubMed ID: 21627359
The role of p16(INK4a) immunostaining in the risk assessment of women with LSIL cytology: a prospective pragmatic study.
Valasoulis G, Tsoumpou I, Founta C, Kyrgiou M, Dalkalitsis N, Nasioutziki M, Kassanos D, Paraskevaidis E, Karakitsos P
Eur J Gynaecol Oncol. 2011
PubMed ID: 21614901
Recurrent chromosomal copy number alterations in sporadic chordomas.
Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ
PLoS One. 2011
PubMed ID: 21602918
Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
Kelly-Spratt KS, Pitteri SJ, Gurley KE, Liggitt D, Chin A, Kennedy J, Wong CH, Zhang Q, Buson TB, Wang H, Hanash SM, Kemp CJ
PLoS One. 2011
PubMed ID: 21589862
Effect of human papillomavirus on cell cycle-related proteins p16INK4A, p21waf1/cip1, p53 and cyclin D1 in sinonasal inverted papilloma and laryngeal carcinoma. An in situ hybridization study.
Stasikowska-Kanicka O, Wągrowska-Danilewicz M, Danilewicz M
Folia Histochem Cytobiol. 2011
PubMed ID: 21526487
Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis.
Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Neumann-Domer E, Liu Z, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR
PLoS One. 2011
PubMed ID: 21526190
Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples.
Mizuarai S, Machida T, Kobayashi T, Komatani H, Itadani H, Kotani H
Mol Cancer. 2011
PubMed ID: 21447152
p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.
Li Y, Tollefsbol TO
PLoS One. 2011
PubMed ID: 21390332
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Cardiogenics, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Mühleisen TW, Muhlestein JB, Münzel T, Musunuru K, Nahrstaedt J, Nelson CP, Nöthen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schäfer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, März W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, CARDIoGRAM Consortium, Samani NJ
Nat Genet. 2011
PubMed ID: 21378990
Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma.
Lu C, Xie H, Wang F, Shen H, Wang J
BMC Cancer. 2011
PubMed ID: 21375764
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Ubiquitin-mediated protein degradation and methylation-induced gene silencing cooperate in the inactivation of the INK4/ARF locus in Burkitt lymphoma cell lines.
Roberti A, Rizzolio F, Lucchetti C, de Leval L, Giordano A
Cell Cycle. 2011
PubMed ID: 21200153
Loss of p16INK4A expression in low-grade ovarian serous carcinomas.
Schlosshauer PW, Deligdisch L, Penault-Llorca F, Fatemi D, Qiao R, Yao S, Pearl M, Yang Z, Sheng T, Dong J
Int J Gynecol Pathol. 2011
PubMed ID: 21131838
Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.
Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H
Mol Cell Biol. 2011
PubMed ID: 21059868
Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets.
Park G, Kang SH, Lee JH, Suh C, Kim M, Park SM, Kim TY, Oh B, Min HJ, Yoon SS, Yang IC, Cho HI, Lee DS, Korean Multiple Myeloma Working Party (KMMWP)
Ann Hematol. 2011
PubMed ID: 20721556
IRIZIO: a Novel Gene Cooperating with PAX3-FOXO1 in Alveolar Rhabdomyosarcoma (ARMS).
Picchione F, Pritchard C, Lagutina I, Janke L, Grosveld GC
Carcinogenesis. 2010
PubMed ID: 21177767
C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells.
Fahham N, Sardari S, Ostad SN, Vaziri B, Ghahremani MH
J Cell Biochem. 2010
PubMed ID: 21053367
Human papillomavirus DNA and P16(INK4A) expression in concurrent esophageal and gastric cardia cancers.
Ding GC, Ren JL, Chang FB, Li JL, Yuan L, Song X, Zhou SL, Guo T, Fan ZM, Zeng Y, Wang LD
World J Gastroenterol. 2010
PubMed ID: 21155014
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells.
LeBoeuf M, Terrell A, Trivedi S, Sinha S, Epstein JA, Olson EN, Morrisey EE, Millar SE
Dev Cell. 2010
PubMed ID: 21093383
Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.
Lacroix M, Caramel J, Goguet-Rubio P, Linares LK, Estrach S, Hatchi E, Rodier G, Lledo G, de Bettignies C, Thépot A, Deraison C, Chébli K, Hovnanian A, Hainaut P, Dubus P, Sardet C, Le Cam L
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21088222
Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations.
Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, Ordi J
Histopathology. 2010
PubMed ID: 21166704
Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.
Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B, Schuster K, Shao C, Larsen JE, Sullivan LA, Honorio S, Xie Y, Scaglioni PP, DiMaio JM, Gazdar AF, Shay JW, Wistuba II, Minna JD
Cancer Res. 2010
PubMed ID: 21118965
MTHFR C677T polymorphism and differential methylation status in gastric cancer: an association with Helicobacter pylori infection.
Neves Filho EH, Alves MK, Lima VP, Rabenhorst SH
Virchows Arch. 2010
PubMed ID: 20957490
INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction.
Wolstein JM, Lee DH, Michaud J, Buot V, Stefanchik B, Plotkin MD
Am J Physiol Renal Physiol. 2010
PubMed ID: 20861074
Contribution of CDKN2A/P16 ( INK4A ), P14 (ARF), CDK4 and BRCA1/2 germline mutations in individuals with suspected genetic predisposition to uveal melanoma.
Buecher B, Gauthier-Villars M, Desjardins L, Lumbroso-Le Rouic L, Levy C, De Pauw A, Bombled J, Tirapo C, Houdayer C, Bressac-de Paillerets B, Stoppa-Lyonnet D
Fam Cancer. 2010
PubMed ID: 20842456
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis. 2010
PubMed ID: 20819778
Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma.
Mohseny AB, Tieken C, van der Velden PA, Szuhai K, de Andrea C, Hogendoorn PC, Cleton-Jansen AM
Genes Chromosomes Cancer. 2010
PubMed ID: 20737480
Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis.
Ferguson B, Konrad Muller H, Handoko HY, Khosrotehrani K, Beermann F, Hacker E, Soyer HP, Bosenberg M, Walker GJ
Pigment Cell Melanoma Res. 2010
PubMed ID: 20718941
High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma.
Jonsson A, Tuominen R, Grafström E, Hansson J, Egyhazi S
J Invest Dermatol. 2010
PubMed ID: 20703244
Up-regulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer.
Matsumoto Y, Marusawa H, Kinoshita K, Niwa Y, Sakai Y, Chiba T
Gastroenterology. 2010
PubMed ID: 20637757
Hepatitis B virus X protein promotes hypermethylation of p16(INK4A) promoter through upregulation of DNA methyltransferases in hepatocarcinogenesis.
Zhu YZ, Zhu R, Shi LG, Mao Y, Zheng GJ, Chen Q, Zhu HG
Exp Mol Pathol. 2010
PubMed ID: 20620135
Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Liang X, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM
Fam Cancer. 2010
PubMed ID: 20574843
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis.
Nogueira C, Kim KH, Sung H, Paraiso KH, Dannenberg JH, Bosenberg M, Chin L, Kim M
Oncogene. 2010
PubMed ID: 20711233
Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A).
Bishop CL, Bergin AM, Fessart D, Borgdorff V, Hatzimasoura E, Garbe JC, Stampfer MR, Koh J, Beach DH
Mol Cell. 2010
PubMed ID: 21095584
mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.
Cam H, Easton JB, High A, Houghton PJ
Mol Cell. 2010
PubMed ID: 21095582
A Flexible Multiplex Bead-Based Assay for Detecting Germline CDKN2A and CDK4 Variants in Melanoma-Prone Kindreds.
Lang JM, Shennan M, Njauw JC, Luo S, Bishop JN, Harland M, Hayward NK, Tucker MA, Goldstein AM, Landi MT, Puig S, Gruis NA, Bergman W, Bianchi-Scarra G, Ghiorzo P, Hogg D, Tsao H
J Invest Dermatol. 2010
PubMed ID: 21085193
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells.
Lee KE, Bar-Sagi D
Cancer Cell. 2010
PubMed ID: 21075310
Critical roles of DMP1 in human epidermal growth factor receptor 2/neu-Arf-p53 signaling and breast cancer development.
Taneja P, Maglic D, Kai F, Sugiyama T, Kendig RD, Frazier DP, Willingham MC, Inoue K
Cancer Res. 2010
PubMed ID: 21062982
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S, Hara E, Ohtani N
Cancer Res. 2010
PubMed ID: 21062974
Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: a multicenter study.
Motomura K, Natsume A, Kishida Y, Higashi H, Kondo Y, Nakasu Y, Abe T, Namba H, Wakai K, Wakabayashi T
Cancer. 2010
PubMed ID: 21061328
Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.
Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G
Cell Stem Cell. 2010
PubMed ID: 21040902
mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion.
Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ
Cell Stem Cell. 2010
PubMed ID: 21040901
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
DNA content and methylation of p16, DAPK and RASSF1A gene in tumour and distant, normal mucosal tissue of head and neck squamous cell carcinoma patients.
Laytragoon-Lewin N, Chen F, Castro J, Elmberger G, Rutqvist LE, Lewin F, Turesson I, Lundgren J
Anticancer Res. 2010
PubMed ID: 21115918
Correlation of cell cycle regulatory proteins (p53 and p16(ink)⁴(a)) and bcl-2 oncoprotein with mitotic index and thickness of primary cutaneous malignant melanoma.
Kostov M, Mijović Z, Mihailović D, Cerović S, Stojanović M, Jelić M
Bosn J Basic Med Sci. 2010
PubMed ID: 21108607
Study of specific genetic and epigenetic variables in multiple myeloma.
Hatzimichael E, Dasoula A, Benetatos L, Syed N, Dranitsaris G, Crook T, Bourantas K
Leuk Lymphoma. 2010
PubMed ID: 21067440
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.
Carragher LA, Snell KR, Giblett SM, Aldridge VS, Patel B, Cook SJ, Winton DJ, Marais R, Pritchard CA
EMBO Mol Med. 2010
PubMed ID: 20941790
p16 expression in squamous and trophoblastic lesions of the upper female genital tract.
Chew I, Post MD, Carinelli SG, Campbell S, Di Y, Soslow RA, Oliva E
Int J Gynecol Pathol. 2010
PubMed ID: 20881863
Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.
Rotger M, Gsponer T, Martinez R, Taffé P, Elzi L, Vernazza P, Cavassini M, Bernasconi E, Hirschel B, Furrer H, Weber R, Ledergerber B, Egger M, Telenti A, Tarr PE, Swiss HIV Cohort Study
Clin Infect Dis. 2010
PubMed ID: 20879858
Genetic risk profiles identify different molecular etiologies for glioma.
Simon M, Hosking FJ, Marie Y, Gousias K, Boisselier B, Carpentier C, Schramm J, Mokhtari K, Hoang-Xuan K, Idbaih A, Delattre JY, Lathrop M, Robertson LB, Houlston RS, Sanson M
Clin Cancer Res. 2010
PubMed ID: 20847058
Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health.
Popov N, Gil J
Epigenetics. 2010
PubMed ID: 20716961
Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.
Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y
Am J Respir Crit Care Med. 2010
PubMed ID: 20595226
Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine.
Lin HH, Ke HL, Huang SP, Wu WJ, Chen YK, Chang LL
Urol Oncol. 2010
PubMed ID: 19181545
Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction.
Peters BJ, Rodin AS, Klungel OH, Stricker BH, de Boer A, Maitland-van der Zee AH
Pharmacogenet Genomics. 2010
PubMed ID: 21037509
Somatic p16(INK4a) loss accelerates melanomagenesis.
Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE
Oncogene. 2010
PubMed ID: 20697345
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.
Ripatti S, Tikkanen E, Orho-Melander M, Havulinna AS, Silander K, Sharma A, Guiducci C, Perola M, Jula A, Sinisalo J, Lokki ML, Nieminen MS, Melander O, Salomaa V, Peltonen L, Kathiresan S
Lancet. 2010
PubMed ID: 20971364
Identification and characterization of Bmi-1-responding element within the human p16 promoter.
Meng S, Luo M, Sun H, Yu X, Shen M, Zhang Q, Zhou R, Ju X, Tao W, Liu D, Deng H, Lu Z
J Biol Chem. 2010
PubMed ID: 20551323
c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.
Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
Oncogene. 2010
PubMed ID: 20676132
Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study.
Demenais F, Mohamdi H, Chaudru V, Goldstein AM, Newton Bishop JA, Bishop DT, Kanetsky PA, Hayward NK, Gillanders E, Elder DE, Avril MF, Azizi E, van Belle P, Bergman W, Bianchi-Scarrà G, Bressac-de Paillerets B, Calista D, Carrera C, Hansson J, Harland M, Hogg D, Höiom V, Holland EA, Ingvar C, Landi MT, Lang JM, Mackie RM, Mann GJ, Ming ME, Njauw CJ, Olsson H, Palmer J, Pastorino L, Puig S, Randerson-Moor J, Stark M, Tsao H, Tucker MA, van der Velden P, Yang XR, Gruis N, Melanoma Genetics Consortium
J Natl Cancer Inst. 2010
PubMed ID: 20876876
New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice.
Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G
Dev Biol. 2010
PubMed ID: 20707993
Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.
Zhang Y, Cao H, Wang M, Zhao WY, Shen ZY, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
World J Gastroenterol. 2010
PubMed ID: 20872974
Immature B-cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia.
Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K
Blood. 2010
PubMed ID: 20562326
Functional Polymorphisms Associated with Disease-Free Survival in Resected Carcinoma of the Esophagus.
Boonstra JJ, van Marion R, Tilanus HW, Dinjens WN
J Gastrointest Surg. 2010
PubMed ID: 20922573
[Expression of ubiquitin associated protein 1 gene and tumor-suppressor gene p16 in acute leukemia].
Guan LJ, Zhang JH, Wang YX, Zhang N, Hu YP, Li ZG, Zhao W
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 21129243
[Study of loss of heterozygosity at 9p21 and P16 expression in gastrointestinal stromal tumors].
Zhang Y, Cao H, Wang M, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
Zhonghua Wei Chang Wai Ke Za Zhi. 2010
PubMed ID: 20972908
Comparative evaluation of nm23 and p16 expression as biomarkers of high-risk human papillomavirus infection and cervical intraepithelial neoplasia 2(+) lesions of the uterine cervix.
Benevolo M, Terrenato I, Mottolese M, Marandino F, Muti P, Carosi M, Rollo F, Ronchetti L, Mariani L, Vocaturo G, Vocaturo A
Histopathology. 2010
PubMed ID: 20955383
Immunohistochemical expression of p16(INK4A) protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long-term follow-up.
Montebugnoli L, Cervellati F, Cocchi R, Farnedi A, Pennesi MG, Flamminio F, Foschini MP
Histopathology. 2010
PubMed ID: 20955378
Expression of pRb, p53, p16 and cyclin D1 and their clinical implications in urothelial carcinoma.
Lee K, Jung ES, Choi YJ, Lee KY, Lee A
J Korean Med Sci. 2010
PubMed ID: 20890425
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, the MAGIC Investigators, the DIAGRAM Investigators, Meigs JB
Diabetes Care. 2010
PubMed ID: 20889853
P16/CDKN2A and Ki-67 enhance the detection of anal intraepithelial neoplasia and condyloma and correlate with human papillomavirus detection by polymerase chain reaction.
Pirog EC, Quint KD, Yantiss RK
Am J Surg Pathol. 2010
PubMed ID: 20871219
Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.
Musunuru K, Post WS, Herzog W, Shen H, O'Connell JR, McArdle PF, Ryan KA, Gibson Q, Cheng YC, Clearfield E, Johnson AD, Tofler G, Yang Q, O'Donnell CJ, Becker DM, Yanek LR, Becker LC, Faraday N, Bielak LF, Peyser PA, Shuldiner AR, Mitchell BD
Circ Cardiovasc Genet. 2010
PubMed ID: 20858905
The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells.
Fernandez-Diaz LC, Laurent A, Girasoli S, Turco M, Longobardi E, Iotti G, Jenkins NA, Fiorenza MT, Copeland NG, Blasi F
Development. 2010
PubMed ID: 20826531
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
Chen M, Voeller D, Marquez VE, Kaye FJ, Steeg PS, Giaccone G, Zajac-Kaye M
Int J Oncol. 2010
PubMed ID: 20811718
p16(INK4A) promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner.
Su PF, Huang WL, Wu HT, Wu CH, Liu TY, Kao SY
Oral Oncol. 2010
PubMed ID: 20729138
Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome.
Rodrigues EF, Santos-Rebouças CB, Gonçalves Pimentel MM, Mencalha AL, Dobbin J, Da Costa ES, Fernandez Cde S, Bouzas LF, Abdelhay E, De Souza Fernandez T
Leuk Lymphoma. 2010
PubMed ID: 20658957
Upregulation of CDKN2A and suppression of cyclin D1 gene expressions in ACTH-secreting pituitary adenomas.
Tani Y, Inoshita N, Sugiyama T, Kato M, Yamada S, Shichiri M, Hirata Y
Eur J Endocrinol. 2010
PubMed ID: 20616110
Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
Fontaine-Bisson B, Renström F, Rolandsson O, MAGIC, Payne F, Hallmans G, Barroso I, Franks PW
Diabetologia. 2010
PubMed ID: 20571754
p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters.
Fischer CA, Kampmann M, Zlobec I, Green E, Tornillo L, Lugli A, Wolfensberger M, Terracciano LM
Ann Oncol. 2010
PubMed ID: 20423915
p16(INK4a) overexpression predicts translational active human papillomavirus infection in tonsillar cancer.
Hoffmann M, Ihloff AS, Görögh T, Weise JB, Fazel A, Krams M, Rittgen W, Schwarz E, Kahn T
Int J Cancer. 2010
PubMed ID: 20091864
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
Wang S, Tian C, Xing G, Gao M, Jiao W, Xiao T, Yin Y, He F, Zhang L
FEBS Lett. 2010
PubMed ID: 20713054
Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial.
Rischin D, Young RJ, Fisher R, Fox SB, Le QT, Peters LJ, Solomon B, Choi J, O'Sullivan B, Kenny LM, McArthur GA
J Clin Oncol. 2010
PubMed ID: 20697079
Structural conservation of components in the amino acid sensing branch of the TOR pathway in yeast and mammals.
Kogan K, Spear ED, Kaiser CA, Fass D
J Mol Biol. 2010
PubMed ID: 20655927
SM22α-induced activation of p16INK4a/retinoblastoma pathway promotes cellular senescence caused by a subclinical dose of γ-radiation and doxorubicin in HepG2 cells.
Kim TR, Lee HM, Lee SY, Kim EJ, Kim KC, Paik SG, Cho EW, Kim IG
Biochem Biophys Res Commun. 2010
PubMed ID: 20705054
Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence.
Li H, Wang W, Liu X, Paulson KE, Yee AS, Zhang X
Oncogene. 2010
PubMed ID: 20581871
GRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.
Sun P, Nallar SC, Raha A, Kalakonda S, Velalar CN, Reddy SP, Kalvakolanu DV
J Biol Chem. 2010
PubMed ID: 20522552
Promoter methylation of p16, Runx3, DAPK and CHFR genes is frequent in gastric carcinoma.
Hu SL, Kong XY, Cheng ZD, Sun YB, Shen G, Xu WP, Wu L, Xu XC, Jiang XD, Huang DB
Tumori. 2010
PubMed ID: 21302620
High-risk HPV DNA status and p16 (INK4a) expression as prognostic markers in patients with squamous cell cancer of oral cavity and oropharynx.
Śnietura M, Jaworska M, Pigłowski W, Goraj-Zając A, Woźniak G, Lange D
Pol J Pathol. 2010
PubMed ID: 21225495
Genetic determinants of cutaneous melanoma predisposition.
Udayakumar D, Mahato B, Gabree M, Tsao H
Semin Cutan Med Surg. 2010
PubMed ID: 21051013
[Value of detecting p16 gene methylation in the diagnosis of malignant pleural effusion].
Liu DY, Zhou FL, Hu ZJ, Hu HB
Nan Fang Yi Ke Da Xue Xue Bao. 2010
PubMed ID: 20855275
Obesity and diabetes genetic variants associated with gestational weight gain.
Stuebe AM, Lyon H, Herring AH, Ghosh J, Wise A, North KE, Siega-Riz AM
Am J Obstet Gynecol. 2010
PubMed ID: 20816152
p16 Immunoreactivity in unusual types of cervical adenocarcinoma does not reflect human papillomavirus infection.
Houghton O, Jamison J, Wilson R, Carson J, McCluggage WG
Histopathology. 2010
PubMed ID: 20727021
Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model.
Sanchez-Ruderisch H, Fischer C, Detjen KM, Welzel M, Wimmel A, Manning JC, André S, Gabius HJ
FEBS J. 2010
PubMed ID: 20695889
Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.
Pehlivan S, Artac M, Sever T, Bozcuk H, Kilincarslan C, Pehlivan M
Cancer Genet Cytogenet. 2010
PubMed ID: 20682398
Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.
Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A
Hepatology. 2010
PubMed ID: 20648475
Genetic analysis of three important genes in pigmentation and melanoma susceptibility: CDKN2A, MC1R and HERC2/OCA2.
Ibarrola-Villava M, Fernandez LP, Pita G, Bravo J, Floristan U, Sendagorta E, Feito M, Avilés JA, Martin-Gonzalez M, Lázaro P, Benítez J, Ribas G
Exp Dermatol. 2010
PubMed ID: 20629734
Coronary artery calcification and its relationship to validated genetic variants for diabetes mellitus assessed in the Heinz Nixdorf recall cohort.
Pechlivanis S, Scherag A, Mühleisen TW, Möhlenkamp S, Horsthemke B, Boes T, Bröcker-Preuss M, Mann K, Erbel R, Jöckel KH, Nöthen MM, Moebus S, Heinz Nixdorf Recall Study Group
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20616309
Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM).
Carter H, Samayoa J, Hruban RH, Karchin R
Cancer Biol Ther. 2010
PubMed ID: 20581473
Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S.
Hong J, Resnick M, Behar J, Wang LJ, Wands J, DeLellis RA, Souza RF, Spechler SJ, Cao W
Am J Physiol Gastrointest Liver Physiol. 2010
PubMed ID: 20576920
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, Faerch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Hansen T, Pedersen O
Diabetologia. 2010
PubMed ID: 20490451
Associations of risk factors obesity and occupational airborne exposures with CDKN2A/p16 aberrant DNA methylation in esophageal cancer patients.
Mohammad Ganji S, Miotto E, Callegari E, Sayehmiri K, Fereidooni F, Yazdanbod M, Rastgar-Jazii F, Negrini M
Dis Esophagus. 2010
PubMed ID: 20459442
Survey of familial glioma and role of germline p16 ( INK4A ) /p14 ( ARF ) and p53 mutation.
Robertson LB, Armstrong GN, Olver BD, Lloyd AL, Shete S, Lau C, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Bernstein JL, Olson SH, Jenkins RB, Yang P, Rynerason AL, Wrensch M, McCoy L, Wienkce JK, McCarthy B, Davis F, Vick NA, Johansen C, Bødtcher H, Sadetzki S, Bruchim RB, Yechezkel GH, Andersson U, Melin BS, Bondy ML, Houlston RS
Fam Cancer. 2010
PubMed ID: 20455025
Loss of p16INK4, alone and with overexpression of osteopontin, correlates with survival of patients with spinal metastasis from hepatocellular carcinoma.
Chen HJ, Xiao JR, Yuan W
Med Oncol. 2010
PubMed ID: 19813107
A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma.
Zhao X, Song T, He Z, Tang L, Zhu Y
Med Oncol. 2010
PubMed ID: 19806481
Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study.
Jardin F, Jais JP, Molina TJ, Parmentier F, Picquenot JM, Ruminy P, Tilly H, Bastard C, Salles GA, Feugier P, Thieblemont C, Gisselbrecht C, de Reynies A, Coiffier B, Haioun C, Leroy K
Blood. 2010
PubMed ID: 20435884
Ischemia dysregulates DNA methyltransferases and p16INK4a methylation in human colorectal cancer cells.
Skowronski K, Dubey S, Rodenhiser D, Coomber B
Epigenetics. 2010
PubMed ID: 20543577
S-phase lengthening induced by p16(INK4a) overexpression in malignant cells with wild-type pRb and p53.
Chien WW, Domenech C, Catallo R, Salles G, Ffrench M
Cell Cycle. 2010
PubMed ID: 20703084
p16INK4A overexpression in precancerous and cancerous lesions of the uterine cervix in Tunisian women.
Missaoui N, Trabelsi A, Hmissa S, Fontanière B, Yacoubi MT, Mokni M, Korbi S, Frappart L
Pathol Res Pract. 2010
PubMed ID: 20400236
Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.
Mitsunaga S, Fujii S, Ishii G, Kinoshita T, Hasebe T, Aoyagi K, Sasaki H, Ochiai A
Int J Cancer. 2010
PubMed ID: 20013810
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A, Arkan MC, Kirchner T, Greten FR
Cancer Cell. 2010
PubMed ID: 20708155
Detection of aberrant p16INK4A methylation in sera of patients with HCV-related liver diseases: An Egyptian study.
Ahmed R, Salama H, Fouad A, Sabry D, AbdAlah el-S, Kamal M
Med Sci Monit. 2010
PubMed ID: 20802412
Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans.
Roder C, Peters V, Kasuya H, Nishizawa T, Takehara Y, Berg D, Schulte C, Khan N, Tatagiba M, Krischek B
Childs Nerv Syst. 2010
PubMed ID: 20694560
Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle.
Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM
Cell Stem Cell. 2010
PubMed ID: 20682446
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
Maertens GN, El Messaoudi-Aubert S, Elderkin S, Hiom K, Peters G
EMBO J. 2010
PubMed ID: 20601937
Additive effect of multiple genetic variants on the risk of coronary artery disease.
Lluís-Ganella C, Lucas G, Subirana I, Sentí M, Jimenez-Conde J, Marrugat J, Tomás M, Elosua R
Rev Esp Cardiol. 2010
PubMed ID: 20738937
Reactivating the ARF-p53 axis in AML cells by targeting ULF.
Chen D, Yoon JB, Gu W
Cell Cycle. 2010
PubMed ID: 20699639
The pattern of p14ARF expression in primary and metastatic human endometrial carcinomas: correlation with clinicopathological features and TP53 pathway alterations.
Olcha P, Cybulski M, Skomra D, Obrzut B, Ignatov A, Jóźwik M, Schneider-Stock R, Semczuk A
Int J Gynecol Cancer. 2010
PubMed ID: 20683407
DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas.
Iizuka D, Imaoka T, Takabatake T, Nishimura M, Kakinuma S, Nishimura Y, Shimada Y
Radiat Res. 2010
PubMed ID: 20681787
Novel CDKN2A mutation detected in Spanish melanoma pedigree.
de Torre C, Martínez-Escribano J
Exp Dermatol. 2010
PubMed ID: 20653773
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
Gretarsdottir S, Baas AF, Thorleifsson G, Holm H, den Heijer M, de Vries JP, Kranendonk SE, Zeebregts CJ, van Sterkenburg SM, Geelkerken RH, van Rij AM, Williams MJ, Boll AP, Kostic JP, Jonasdottir A, Jonasdottir A, Walters GB, Masson G, Sulem P, Saemundsdottir J, Mouy M, Magnusson KP, Tromp G, Elmore JR, Sakalihasan N, Limet R, Defraigne JO, Ferrell RE, Ronkainen A, Ruigrok YM, Wijmenga C, Grobbee DE, Shah SH, Granger CB, Quyyumi AA, Vaccarino V, Patel RS, Zafari AM, Levey AI, Austin H, Girelli D, Pignatti PF, Olivieri O, Martinelli N, Malerba G, Trabetti E, Becker LC, Becker DM, Reilly MP, Rader DJ, Mueller T, Dieplinger B, Haltmayer M, Urbonavicius S, Lindblad B, Gottsäter A, Gaetani E, Pola R, Wells P, Rodger M, Forgie M, Langlois N, Corral J, Vicente V, Fontcuberta J, España F, Grarup N, Jørgensen T, Witte DR, Hansen T, Pedersen O, Aben KK, de Graaf J, Holewijn S, Folkersen L, Franco-Cereceda A, Eriksson P, Collier DA, Stefansson H, Steinthorsdottir V, Rafnar T, Valdimarsson EM, Magnadottir HB, Sveinbjornsdottir S, Olafsson I, Magnusson MK, Palmason R, Haraldsdottir V, Andersen K, Onundarson PT, Thorgeirsson G, Kiemeney LA, Powell JT, Carey DJ, Kuivaniemi H, Lindholt JS, Jones GT, Kong A, Blankensteijn JD, Matthiasson SE, Thorsteinsdottir U, Stefansson K
Nat Genet. 2010
PubMed ID: 20622881
Arsenic trioxide inhibits DNA methyltransferase and restores expression of methylation-silenced CDKN2B/CDKN2A genes in human hematologic malignant cells.
Fu HY, Shen JZ, Wu Y, Shen SF, Zhou HR, Fan LP
Oncol Rep. 2010
PubMed ID: 20596618
p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status.
Lewis JS, Thorstad WL, Chernock RD, Haughey BH, Yip JH, Zhang Q, El-Mofty SK
Am J Surg Pathol. 2010
PubMed ID: 20588174
Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming.
Ron-Bigger S, Bar-Nur O, Isaac S, Bocker M, Lyko F, Eden A
Stem Cells. 2010
PubMed ID: 20572015
HMGA2 and the p19Arf-TP53-CDKN1A axis: a delicate balance in the growth of uterine leiomyomas.
Markowski DN, von Ahsen I, Nezhad MH, Wosniok W, Helmke BM, Bullerdiek J
Genes Chromosomes Cancer. 2010
PubMed ID: 20544840
Swedish CDKN2A mutation carriers do not present the atypical mole syndrome phenotype.
Nielsen K, Harbst K, Måsbäck A, Jönsson G, Borg A, Olsson H, Ingvar C
Melanoma Res. 2010
PubMed ID: 20526219
PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S
Mol Cell Biol. 2010
PubMed ID: 20498273
Alterations in p16 and p53 genes and chromosomal findings in patients with lung cancer: fluorescence in situ hybridization and cytogenetic studies.
Demirhan O, Taştemir D, Hastürk S, Kuleci S, Hanta I
Cancer Epidemiol. 2010
PubMed ID: 20444664
An analysis on the combination expression of HPV L1 capsid protein and p16INK4a in cervical lesions.
Huang MZ, Li HB, Nie XM, Wu XY, Jiang XM
Diagn Cytopathol. 2010
PubMed ID: 19941368
Cross-species genomics matches driver mutations and cell compartments to model ependymoma.
Johnson RA, Wright KD, Poppleton H, Mohankumar KM, Finkelstein D, Pounds SB, Rand V, Leary SE, White E, Eden C, Hogg T, Northcott P, Mack S, Neale G, Wang YD, Coyle B, Atkinson J, DeWire M, Kranenburg TA, Gillespie Y, Allen JC, Merchant T, Boop FA, Sanford RA, Gajjar A, Ellison DW, Taylor MD, Grundy RG, Gilbertson RJ
Nature. 2010
PubMed ID: 20639864
Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer.
Goto T, Mizukami H, Shirahata A, Yokomizo K, Kitamura YH, Sakuraba K, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K
Anticancer Res. 2010
PubMed ID: 20683001
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.
Johnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin J, Wong KK, Su L, Zhou D, Sharpless NE
J Clin Invest. 2010
PubMed ID: 20577054
The sensitivity and specificity of p16(INK4a) cytology vs HPV testing for detecting high-grade cervical disease in the triage of ASC-US and LSIL pap cytology results.
Denton KJ, Bergeron C, Klement P, Trunk MJ, Keller T, Ridder R, European CINtec Cytology Study Group
Am J Clin Pathol. 2010
PubMed ID: 20551261
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
El Messaoudi-Aubert S, Nicholls J, Maertens GN, Brookes S, Bernstein E, Peters G
Nat Struct Mol Biol. 2010
PubMed ID: 20543829
Conditional ablation of Ikkb inhibits melanoma tumor development in mice.
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A
J Clin Invest. 2010
PubMed ID: 20530876
Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
Farias LC, Fraga CA, De Oliveira MV, Silva TF, Marques-Silva L, Moreira PR, De-Paula AM, Gomez RS, Guimarães AL
Int J Oncol. 2010
PubMed ID: 20514408
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, Chen LZ, Feng QS, Low HQ, Zhang H, He F, Tai ES, Kang T, Liu ET, Liu J, Zeng YX
Nat Genet. 2010
PubMed ID: 20512145
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.
Zhang J, Lu A, Li L, Yue J, Lu Y
Cancer Invest. 2010
PubMed ID: 20307196
Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder.
Gould VE, Schmitt M, Vinokurova S, Reddy VB, Bitterman P, Alonso A, Gattuso P
Cancer Lett. 2010
PubMed ID: 20036459
Can a phenotype for recessive inheritance in breast cancer be defined?
Ellberg C, Jönsson G, Olsson H
Fam Cancer. 2010
PubMed ID: 20549370
MTHFR, MTR, and MTRR Polymorphisms in Relation to p16INK4A Hypermethylation in Mucosa of Patients with Colorectal Cancer.
Wettergren Y, Odin E, Carlsson G, Gustavsson B
Mol Med. 2010
PubMed ID: 20549016
H3K27 trimethylation is an early epigenetic event of p16INK4a silencing for regaining tumorigenesis in fusion reprogrammed hepatoma cells.
Yao JY, Zhang L, Zhang X, He ZY, Ma Y, Hui LJ, Wang X, Hu YP
J Biol Chem. 2010
PubMed ID: 20382980
[Methylation and expression of gene p16INK4a and RB in breast carcinoma].
Zhao YF, Shen SP, Jiang JY, Geng H, Guo JG, Xie LP
Zhonghua Bing Li Xue Za Zhi. 2010
PubMed ID: 21055153
ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA.
Kawagishi H, Nakamura H, Maruyama M, Mizutani S, Sugimoto K, Takagi M, Sugimoto M
Cancer Res. 2010
PubMed ID: 20501856
Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras.
Young NP, Jacks T
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20479239
Interaction between 5 genetic variants and allergy in glioma risk.
Schoemaker MJ, Robertson L, Wigertz A, Jones ME, Hosking FJ, Feychting M, Lönn S, McKinney PA, Hepworth SJ, Muir KR, Auvinen A, Salminen T, Kiuru A, Johansen C, Houlston RS, Swerdlow AJ
Am J Epidemiol. 2010
PubMed ID: 20462933
Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk.
Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J, Papaemmanuil E, Bartram CR, Stanulla M, Schrappe M, Gast A, Dobbins SE, Ma Y, Sheridan E, Taylor M, Kinsey SE, Lightfoot T, Roman E, Irving JA, Allan JM, Moorman AV, Harrison CJ, Tomlinson IP, Richards S, Zimmermann M, Szalai C, Semsei AF, Erdelyi DJ, Krajinovic M, Sinnett D, Healy J, Gonzalez Neira A, Kawamata N, Ogawa S, Koeffler HP, Hemminki K, Greaves M, Houlston RS
Nat Genet. 2010
PubMed ID: 20453839
Genome-wide association study identifies five new breast cancer susceptibility loci.
Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, Maranian M, Seal S, Ghoussaini M, Hines S, Healey CS, Hughes D, Warren-Perry M, Tapper W, Eccles D, Evans DG, Breast Cancer Susceptibility Collaboration (UK), Hooning M, Schutte M, van den Ouweland A, Houlston R, Ross G, Langford C, Pharoah PD, Stratton MR, Dunning AM, Rahman N, Easton DF
Nat Genet. 2010
PubMed ID: 20453838
Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3.
Hemmati PG, Müer A, Gillissen B, Overkamp T, Milojkovic A, Wendt J, Dörken B, Daniel PT
J Mol Med. 2010
PubMed ID: 20419447
HPV DNA is associated with a subset of Schneiderian papillomas but does not correlate with p16(INK4a) immunoreactivity.
Shah AA, Evans MF, Adamson CS, Peng Z, Rajendran V, Cooper K
Head Neck Pathol. 2010
PubMed ID: 20405251
Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.
Hashikata H, Liu W, Inoue K, Mineharu Y, Yamada S, Nanayakkara S, Matsuura N, Hitomi T, Takagi Y, Hashimoto N, Miyamoto S, Koizumi A
Stroke. 2010
PubMed ID: 20395613
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma.
Li L, Tao Q, Jin H, van Hasselt A, Poon FF, Wang X, Zeng MS, Jia WH, Zeng YX, Chan AT, Cao Y
Clin Cancer Res. 2010
PubMed ID: 20395212
MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.
Xu Y, Li F, Zhang B, Zhang K, Zhang F, Huang X, Sun N, Ren Y, Sui M, Liu P
Schizophr Res. 2010
PubMed ID: 20347265
Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A.
McKenzie HA, Fung C, Becker TM, Irvine M, Mann GJ, Kefford RF, Rizos H
Hum Mutat. 2010
PubMed ID: 20340136
The susceptibility CDKN2 locus may have a role on prognosis of melanoma patients.
Casula M, Budroni M, Cossu A, Ascierto PA, Mozzillo N, Canzanella S, Muggiano A, Palmieri G
Ann Oncol. 2010
PubMed ID: 20231302
Novel and recurrent p14 mutations in Italian familial melanoma.
Binni F, Antigoni I, De Simone P, Majore S, Silipo V, Crisi A, Amantea A, Pacchiarini D, Castori M, De Bernardo C, Catricalà C, Grammatico P
Clin Genet. 2010
PubMed ID: 20132244
The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.
Lessard F, Morin F, Ivanchuk S, Langlois F, Stefanovsky V, Rutka J, Moss T
Mol Cell. 2010
PubMed ID: 20513429
p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis.
González-Navarro H, Abu Nabah YN, Vinué A, Andrés-Manzano MJ, Collado M, Serrano M, Andrés V
J Am Coll Cardiol. 2010
PubMed ID: 20381282
Basaloid lesions of oral squamous epithelial cells and their association with HPV infection and P16 expression.
Friedrich RE, Sperber C, Jäkel T, Röser K, Löning T
Anticancer Res. 2010
PubMed ID: 20592349
Clinical nodal staging of T1-2 tonsillar squamous cell carcinoma stratified by p16 status and implications for ipsilateral neck irradiation.
Shoushtari AN, Meeneghan M, Treharne GC, Reibel JF, Levine PA, Moskaluk CA, Jameson MJ, Read PW
Cancer J. 2010
PubMed ID: 20526108
Tumor-initiated inflammation overrides protective adaptive immunity in an induced melanoma model in mice.
Soudja SM, Wehbe M, Mas A, Chasson L, de Tenbossche CP, Huijbers I, Van den Eynde B, Schmitt-Verhulst AM
Cancer Res. 2010
PubMed ID: 20406967
Sleeping beauty-mediated somatic mutagenesis implicates CSF1 in the formation of high-grade astrocytomas.
Bender AM, Collier LS, Rodriguez FJ, Tieu C, Larson JD, Halder C, Mahlum E, Kollmeyer TM, Akagi K, Sarkar G, Largaespada DA, Jenkins RB
Cancer Res. 2010
PubMed ID: 20388773
Carcinogenesis and cellular immortalization without persistent inactivation of p16/Rb pathway in lung cancer.
Arifin M, Tanimoto K, Putra AC, Hiyama E, Nishiyama M, Hiyama K
Int J Oncol. 2010
PubMed ID: 20372796
Genome-wide association study of intracranial aneurysm identifies three new risk loci.
Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok YM, Niemelä M, Tajima A, von und zu Fraunberg M, Dóczi T, Wirjatijasa F, Hata A, Blasco J, Oszvald A, Kasuya H, Zilani G, Schoch B, Singh P, Stüer C, Risselada R, Beck J, Sola T, Ricciardi F, Aromaa A, Illig T, Schreiber S, van Duijn CM, van den Berg LH, Perret C, Proust C, Roder C, Ozturk AK, Gaál E, Berg D, Geisen C, Friedrich CM, Summers P, Frangi AF, State MW, Wichmann HE, Breteler MM, Wijmenga C, Mane S, Peltonen L, Elio V, Sturkenboom MC, Lawford P, Byrne J, Macho J, Sandalcioglu EI, Meyer B, Raabe A, Steinmetz H, Rüfenacht D, Jääskeläinen JE, Hernesniemi J, Rinkel GJ, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Günel M
Nat Genet. 2010
PubMed ID: 20364137
MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis.
Fargnoli MC, Gandini S, Peris K, Maisonneuve P, Raimondi S
Eur J Cancer. 2010
PubMed ID: 20189796
Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression.
Li Y, Liu L, Tollefsbol TO
FASEB J. 2010
PubMed ID: 20019239
CDKN2A but not TP53 mutations nor HPV presence predict poor outcome in metastatic squamous cell carcinoma of the skin.
Küsters-Vandevelde HV, Van Leeuwen A, Verdijk MA, de Koning MN, Quint WG, Melchers WJ, Ligtenberg MJ, Blokx WA
Int J Cancer. 2010
PubMed ID: 19739123
Genomic profiling of adult acute lymphoblastic leukemia (ALL) by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric ALL.
Okamoto R, Ogawa S, Nowak D, Kawamata N, Akagi T, Kato M, Sanada M, Weiss T, Haferlach C, Dugas M, Ruckert C, Haferlach T, Koeffler HP
Haematologica. 2010
PubMed ID: 20435627
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety.
Gleason G, Liu B, Bruening S, Zupan B, Auerbach A, Mark W, Oh JE, Gal-Toth J, Lee F, Toth M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20368423
Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.
Yoshioka H, Noguchi K, Katayama K, Mitsuhashi J, Yamagoe S, Fujimuro M, Sugimoto Y
Biochem Biophys Res Commun. 2010
PubMed ID: 20331971
Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma.
Bisio A, Nasti S, Jordan JJ, Gargiulo S, Pastorino L, Provenzani A, Quattrone A, Queirolo P, Bianchi-Scarrà G, Ghiorzo P, Inga A
Hum Mol Genet. 2010
PubMed ID: 20093296
Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma.
Jung AC, Briolat J, Millon R, de Reyniès A, Rickman D, Thomas E, Abecassis J, Clavel C, Wasylyk B
Int J Cancer. 2010
PubMed ID: 19795456
Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence.
Whibley C, Odell AF, Nedelko T, Balaburski G, Murphy M, Liu Z, Stevens L, Walker JH, Routledge M, Hollstein M
J Biol Chem. 2010
PubMed ID: 20118236
p53-mediated hematopoietic stem and progenitor cell competition.
Bondar T, Medzhitov R
Cell Stem Cell. 2010
PubMed ID: 20362536
Analysis of methylation patterns and expression profiles of p14ARF gene in patients with oral squamous cell carcinoma.
Kordi-Tamandani DM, Moazeni-Roodi A, Rigi Ladez MA, Hashemi M, Birjandian E, Torkamanzehi A
Int J Biol Markers. 2010
PubMed ID: 20586029
[Arsenic trioxide reverses hypermethylation of p16 and activates its transcription in malignant lymphoma cell line CA46].
Zhou HR, Shen JZ, Fu HY, Shen SF, Fan LP
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 20416177
CDKN2A promoter methylation is related to the tumor location and histological subtype and associated with Helicobacter pylori flaA(+) strains in gastric adenocarcinomas.
Alves MK, Lima VP, Ferrasi AC, Rodrigues MA, De Moura Campos Pardini MI, Rabenhorst SH
APMIS. 2010
PubMed ID: 20402675
Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism.
Ruchat SM, Vohl MC, Weisnagel SJ, Rankinen T, Bouchard C, Pérusse L
Ann Med. 2010
PubMed ID: 20384434
Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.
Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA
Cancer Res. 2010
PubMed ID: 20332237
A new system for regulated functional gene expression for gene therapy applications: nuclear delivery of a p16INK4A-estrogen receptor carboxy terminal fusion protein only in the presence of estrogen.
Tamura T, Kanuma T, Nakazato T, Faried LS, Aoki H, Minegishi T
Int J Oncol. 2010
PubMed ID: 20198335
CDKN2A-CDKN2B deletion defines an aggressive subset of cutaneous T-cell lymphoma.
Laharanne E, Chevret E, Idrissi Y, Gentil C, Longy M, Ferrer J, Dubus P, Jouary T, Vergier B, Beylot-Barry M, Merlio JP
Mod Pathol. 2010
PubMed ID: 20118908
CDKN2A and MTAP deletions in peritoneal mesotheliomas are correlated with loss of p16 protein expression and poor survival.
Krasinskas AM, Bartlett DL, Cieply K, Dacic S
Mod Pathol. 2010
PubMed ID: 20081810
Dicer inactivation in osteoprogenitor cells compromises fetal survival and bone formation, while excision in differentiated osteoblasts increases bone mass in the adult mouse.
Gaur T, Hussain S, Mudhasani R, Parulkar I, Colby JL, Frederick D, Kream BE, van Wijnen AJ, Stein JL, Stein GS, Jones SN, Lian JB
Dev Biol. 2010
PubMed ID: 20079730
Improvements in glucose homeostasis in response to regular exercise are influenced by the PPARG Pro12Ala variant: results from the HERITAGE Family Study.
Ruchat SM, Rankinen T, Weisnagel SJ, Rice T, Rao DC, Bergman RN, Bouchard C, Pérusse L
Diabetologia. 2010
PubMed ID: 20043145
Single-cell analysis of p16(INK4a) and p21(WAF1) expression suggests distinct mechanisms of senescence in normal human and Li-Fraumeni Syndrome fibroblasts.
Mirzayans R, Andrais B, Scott A, Paterson MC, Murray D
J Cell Physiol. 2010
PubMed ID: 20039273
Downregulation and aberrant promoter methylation of p16INK4A: a possible novel heritable susceptibility marker to retinoblastoma.
Indovina P, Acquaviva A, De Falco G, Rizzo V, Onnis A, Luzzi A, Giorgi F, Hadjistilianou T, Toti P, Tomei V, Pentimalli F, Carugi A, Giordano A
J Cell Physiol. 2010
PubMed ID: 20039270
Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms.
Wiesner T, Obenauf AC, Cota C, Fried I, Speicher MR, Cerroni L
J Invest Dermatol. 2010
PubMed ID: 19924135
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.
Chen D, Shan J, Zhu WG, Qin J, Gu W
Nature. 2010
PubMed ID: 20208519
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
Dual coding in alternative reading frames correlates with intrinsic protein disorder.
Kovacs E, Tompa P, Liliom K, Kalmar L
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20212158
The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis.
Herkert B, Dwertmann A, Herold S, Abed M, Naud JF, Finkernagel F, Harms GS, Orian A, Wanzel M, Eilers M
J Cell Biol. 2010
PubMed ID: 20308430
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.
Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP
Nature. 2010
PubMed ID: 20237562
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.
Reimann M, Lee S, Loddenkemper C, Dörr JR, Tabor V, Aichele P, Stein H, Dörken B, Jenuwein T, Schmitt CA
Cancer Cell. 2010
PubMed ID: 20227040
Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.
Dowdy CR, Xie R, Frederick D, Hussain S, Zaidi SK, Vradii D, Javed A, Li X, Jones SN, Lian JB, van Wijnen AJ, Stein JL, Stein GS
Hum Mol Genet. 2010
PubMed ID: 20035012
IKKbeta specifically binds to P16 and phosphorylates Ser8 of P16.
Guo Y, Yuan C, Weghorst CM, Li J
Biochem Biophys Res Commun. 2010
PubMed ID: 20152798
Evidence of Interaction between Type 2 Diabetes Susceptibility Genes and Dietary Fat Intake for Adiposity and Glucose Homeostasis-Related Phenotypes.
Ruchat SM, Elks CE, Loos RJ, Vohl MC, Weisnagel SJ, Rankinen T, Bouchard C, Pérusse L
J Nutrigenet Nutrigenomics. 2010
PubMed ID: 20215779
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A
Cell Stem Cell. 2010
PubMed ID: 20207230
[Value of promoter methylation of RASSF1A, p16, and DAPK genes in induced sputum in diagnosing lung cancers].
Peng Z, Shan C, Wang H
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010
PubMed ID: 20360646
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP
J Clin Invest. 2010
PubMed ID: 20197621
Genomic instability--an evolving hallmark of cancer.
Negrini S, Gorgoulis VG, Halazonetis TD
Nat Rev Mol Cell Biol. 2010
PubMed ID: 20177397
Distinctive association of p16INK4a overexpression with penile intraepithelial neoplasia depicting warty and/or basaloid features: a study of 141 cases evaluating a new nomenclature.
Chaux A, Pfannl R, Lloveras B, Alejo M, Clavero O, Lezcano C, Muñoz N, de Sanjosé S, Bosch X, Hernández-Pérez M, Velazquez EF, Cubilla AL
Am J Surg Pathol. 2010
PubMed ID: 20139761
Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.
Hu Q, Akatsuka S, Yamashita Y, Ohara H, Nagai H, Okazaki Y, Takahashi T, Toyokuni S
Lab Invest. 2010
PubMed ID: 20065947
ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.
Holdt LM, Beutner F, Scholz M, Gielen S, Gäbel G, Bergert H, Schuler G, Thiery J, Teupser D
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20056914
Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.
Zhao J, Bradfield JP, Zhang H, Annaiah K, Wang K, Kim CE, Glessner JT, Frackelton EC, Otieno FG, Doran J, Thomas KA, Garris M, Hou C, Chiavacci RM, Li M, Berkowitz RI, Hakonarson H, Grant SF
Diabetes. 2010
PubMed ID: 19933996
Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas: a comparison between Italian and African samples.
Carugi A, Onnis A, Antonicelli G, Rossi B, Mannucci S, Luzzi A, Lazzi S, Bellan C, Tosi GM, Sayed S, De Falco G, Leoncini L
Hematol Oncol. 2010
PubMed ID: 19728399
Expression and methylation pattern of p16 in neuroblastoma tumorigenesis.
Aktas S, Celebiler AC, Zadeoğlulari Z, Diniz G, Kargi A, Olgun N
Pathol Oncol Res. 2010
PubMed ID: 19466588
Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16(INK4a) expression via DNA methylation.
Kim YJ, Jung JK, Lee SY, Jang KL
Cancer Lett. 2010
PubMed ID: 19656618
Prevalence of BRCA2 and CDKN2a mutations in German familial pancreatic cancer families.
Slater EP, Langer P, Fendrich V, Habbe N, Chaloupka B, Matthäi E, Sina M, Hahn SA, Bartsch DK
Fam Cancer. 2010
PubMed ID: 20195775
Diagnostic value of p16INK4A, Ki-67, and human papillomavirus L1 capsid protein immunochemical staining on cell blocks from residual liquid-based gynecologic cytology specimens.
Yu L, Wang L, Zhong J, Chen S
Cancer Cytopathol. 2010
PubMed ID: 20069634
High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma.
Carr-Wilkinson J, O'Toole K, Wood KM, Challen CC, Baker AG, Board JR, Evans L, Cole M, Cheung NK, Boos J, Köhler G, Leuschner I, Pearson AD, Lunec J, Tweddle DA
Clin Cancer Res. 2010
PubMed ID: 20145180
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.
Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP
Blood. 2010
PubMed ID: 20008304
Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells.
Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, Hambardzumyan D, Holland EC
Cell Stem Cell. 2010
PubMed ID: 20144787
ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation.
Miao L, Song Z, Jin L, Zhu YM, Wen LP, Wu M
Oncogene. 2010
PubMed ID: 19901969
Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Chattopadhyay I, Singh A, Phukan R, Purkayastha J, Kataki A, Mahanta J, Saxena S, Kapur S
Mutat Res. 2010
PubMed ID: 20083228
Expression of p16INK4A in gastrointestinal stromal tumours (GISTs): two different forms exist that independently correlate with poor prognosis.
Haller F, Agaimy A, Cameron S, Beyer M, Gunawan B, Happel N, Langer C, Ramadori G, von Heydebreck A, Füzesi L
Histopathology. 2010
PubMed ID: 20459531
Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria.
Irvine M, Philipsz S, Frausto M, Mijatov B, Gallagher SJ, Fung C, Becker TM, Kefford RF, Rizos H
Cell Cycle. 2010
PubMed ID: 20107316
Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors.
Shen J, Barrios RJ, Jaiswal AK
Cancer Res. 2010
PubMed ID: 20103645
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study.
Niini T, López-Guerrero JA, Ninomiya S, Guled M, Hattinger CM, Michelacci F, Böhling T, Llombart-Bosch A, Picci P, Serra M, Knuutila S
Genes Chromosomes Cancer. 2010
PubMed ID: 19862822
Aberrant p16((INK4a)) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity.
Mitomi H, Fukui N, Tanaka N, Kanazawa H, Saito T, Matsuoka T, Yao T
J Cancer Res Clin Oncol. 2010
PubMed ID: 19779933
Coexisting NRAS and BRAF mutations in primary familial melanomas with specific CDKN2A germline alterations.
Jovanovic B, Egyhazi S, Eskandarpour M, Ghiorzo P, Palmer JM, Bianchi Scarrà G, Hayward NK, Hansson J
J Invest Dermatol. 2010
PubMed ID: 19759551
DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance.
Stanganelli C, Arbelbide J, Fantl DB, Corrado C, Slavutsky I
Ann Hematol. 2010
PubMed ID: 19727727
Expression of p53 and p16 in actinic keratosis, bowenoid actinic keratosis and Bowen's disease.
Bagazgoitia L, Cuevas J, Juarranz A
J Eur Acad Dermatol Venereol. 2010
PubMed ID: 19515076
Aging increases p16 INK4a expression in vascular smooth-muscle cells.
Rodriguez-Menocal L, Pham SM, Mateu D, St-Pierre M, Wei Y, Pestana I, Aitouche A, Vazquez-Padron RI
Biosci Rep. 2010
PubMed ID: 19196247
Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.
Robinson JP, VanBrocklin MW, Guilbeault AR, Signorelli DL, Brandner S, Holmen SL
Oncogene. 2010
PubMed ID: 19855433
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas.
Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD
Cancer Res. 2010
PubMed ID: 20068183
Estimating CDKN2A carrier probability and personalizing cancer risk assessments in hereditary melanoma using MelaPRO.
Wang W, Niendorf KB, Patel D, Blackford A, Marroni F, Sober AJ, Parmigiani G, Tsao H
Cancer Res. 2010
PubMed ID: 20068151
Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes.
Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W, Krimpenfort P, Gadiot J, Pritchard C, Lenz J, Lund AH, Jonkers J, Rogers J, Adams DJ, Wessels L, Berns A, van Lohuizen M
Cancer Res. 2010
PubMed ID: 20068150
Quantitative evaluation of DNA hypermethylation in malignant and benign breast tissue and fluids.
Zhu W, Qin W, Hewett JE, Sauter ER
Int J Cancer. 2010
PubMed ID: 19618401
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.
Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TR, Sansom OJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20018721
Role of the translocation partner in protection against AID-dependent chromosomal translocations.
Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC
Proc Natl Acad Sci U S A. 2010
PubMed ID: 19966290
The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice.
Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN
PLoS One. 2010
PubMed ID: 21209895
A role for ATF2 in regulating MITF and melanoma development.
Shah M, Bhoumik A, Goel V, Dewing A, Breitwieser W, Kluger H, Krajewski S, Krajewska M, Dehart J, Lau E, Kallenberg DM, Jeong H, Eroshkin A, Bennett DC, Chin L, Bosenberg M, Jones N, Ronai ZA
PLoS Genet. 2010
PubMed ID: 21203491
p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.
Spallarossa P, Altieri P, Barisione C, Passalacqua M, Aloi C, Fugazza G, Frassoni F, Podestà M, Canepa M, Ghigliotti G, Brunelli C
PLoS One. 2010
PubMed ID: 21187925
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.
Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE
PLoS Genet. 2010
PubMed ID: 21151960
Cell cycle biology of fibrolamellar hepatocellular carcinoma.
Dhingra S, Li W, Tan D, Zenali M, Zhang H, Brown RE
Int J Clin Exp Pathol. 2010
PubMed ID: 21151393
Polycomb CBX7 directly controls trimethylation of histone H3 at lysine 9 at the p16 locus.
Li Q, Wang X, Lu Z, Zhang B, Guan Z, Liu Z, Zhong Q, Gu L, Zhou J, Zhu B, Ji J, Deng D
PLoS One. 2010
PubMed ID: 21060834
Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc.
Gao FH, Hu XH, Li W, Liu H, Zhang YJ, Guo ZY, Xu MH, Wang ST, Jiang B, Liu F, Zhao YZ, Fang Y, Chen FY, Wu YL
BMC Cancer. 2010
PubMed ID: 21054888
EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.
Geddert H, Zur Hausen A, Gabbert HE, Sarbia M
Anal Cell Pathol (Amst). 2010
PubMed ID: 20978327
Lack of p16 gene mutations in gastric cancers in Kashmir.
Bashir SA, Pandith AA, Yousuf A, Parveen N, Siddiqi MA, Muddassar S, Andrabi KI, Abdin MZ
Asian Pac J Cancer Prev. 2010
PubMed ID: 20843112
An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients.
Ducray F, de Reyniès A, Chinot O, Idbaih A, Figarella-Branger D, Colin C, Karayan-Tapon L, Chneiweiss H, Wager M, Vallette F, Marie Y, Rickman D, Thomas E, Delattre JY, Honnorat J, Sanson M, Berger F
Mol Cancer. 2010
PubMed ID: 20822523
Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical lesions progression risk.
Ungureanu C, Socolov D, Anton G, Mihailovici MS, Teleman S
Rom J Morphol Embryol. 2010
PubMed ID: 20809026
A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.
Negishi M, Saraya A, Mochizuki S, Helin K, Koseki H, Iwama A
PLoS One. 2010
PubMed ID: 20808772
Loss of p19(Arf) facilitates the angiogenic switch and tumor initiation in a multi-stage cancer model via p53-dependent and independent mechanisms.
Ulanet DB, Hanahan D
PLoS One. 2010
PubMed ID: 20805995
Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
Morgan AR, Thompson JM, Murphy R, Black PN, Lam WJ, Ferguson LR, Mitchell EA
BMC Med Genet. 2010
PubMed ID: 20712903
Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China.
Jin Y, Xu H, Zhang C, Kong Y, Hou Y, Xu Y, Xue S
BMC Cancer. 2010
PubMed ID: 20704749
Frequency of P16INK4a and P14ARF genes methylation and its impact on bladder cancer cases in north Indian population.
Ali Hosseini S, Sobti RC, Malekzadeh K, Singh SK, Joshi K
Dis Markers. 2010
PubMed ID: 20683150
p16INK4a expression in basal-like breast carcinoma.
Bohn OL, Fuertes-Camilo M, Navarro L, Saldivar J, Sanchez-Sosa S
Int J Clin Exp Pathol. 2010
PubMed ID: 20661408
Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma.
Csepregi A, Ebert MP, Röcken C, Schneider-Stock R, Hoffmann J, Schulz HU, Roessner A, Malfertheiner P
BMC Cancer. 2010
PubMed ID: 20569442
Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6.
Merkel CA, da Silva Soares RB, de Carvalho AC, Zanatta DB, Bajgelman MC, Fratini P, Costanzi-Strauss E, Strauss BE
BMC Cancer. 2010
PubMed ID: 20569441
Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue.
Celebiler Cavusoglu A, Sevinc AI, Saydam S, Canda T, Baskan Z, Kilic Y, Sakizli M
Neoplasma. 2010
PubMed ID: 20568901
Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549.
Zhang W, Zhu J, Bai J, Jiang H, Liu F, Liu A, Liu P, Ji G, Guan R, Sun D, Ji W, Yu Y, Jin Y, Meng X, Fu S
J Exp Clin Cancer Res. 2010
PubMed ID: 20565749
Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
Lin Y, Li P, Cai L, Zhang B, Tang X, Zhang X, Li Y, Xian Y, Yang Y, Wang L, Lu F, Liu X, Rao S, Chen M, Ma S, Shi Y, Bao M, Wu J, Yang Y, Yang J, Yang Z
BMC Med Genet. 2010
PubMed ID: 20550665
Epigenetic repression of p16(INK4A) by latent Epstein-Barr virus requires the interaction of EBNA3A and EBNA3C with CtBP.
Skalska L, White RE, Franz M, Ruhmann M, Allday MJ
PLoS Pathog. 2010
PubMed ID: 20548956
Decreasing expression of the G1-phase inhibitors, p21Cip1 and p16INK4a, promotes division of corneal endothelial cells from older donors.
Joyce NC, Harris DL
Mol Vis. 2010
PubMed ID: 20508865
p16INK4a hypermethylation and p53, p16 and MDM2 protein expression in esophageal squamous cell carcinoma.
Taghavi N, Biramijamal F, Sotoudeh M, Khademi H, Malekzadeh R, Moaven O, Memar B, A'rabi A, Abbaszadegan MR
BMC Cancer. 2010
PubMed ID: 20388212
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression.
Cunnington MS, Santibanez Koref M, Mayosi BM, Burn J, Keavney B
PLoS Genet. 2010
PubMed ID: 20386740
Detection of HPV and the role of p16INK4A overexpression as a surrogate marker for the presence of functional HPV oncoprotein E7 in colorectal cancer.
Deschoolmeester V, Van Marck V, Baay M, Weyn C, Vermeulen P, Van Marck E, Lardon F, Fontaine V, Vermorken JB
BMC Cancer. 2010
PubMed ID: 20346145
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J
Mol Cancer. 2010
PubMed ID: 20338046
Expression and alteration of p16 in diffuse large B cell lymphoma.
Lee ES, Kim LH, Abdullah WA, Peh SC
Pathobiology. 2010
PubMed ID: 20332669
Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
Wen J, Rönn T, Olsson A, Yang Z, Lu B, Du Y, Groop L, Ling C, Hu R
PLoS One. 2010
PubMed ID: 20161779
Gene methylation in breast ductal fluid from BRCA1 and BRCA2 mutation carriers.
Antill YC, Mitchell G, Johnson SA, Devereux L, Milner A, Di Iulio J, Lindeman GJ, Kirk J, Phillips KA, Campbell IG
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20056647
Characterization of melanoma cells capable of propagating tumors from a single cell.
Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW
Cancer Res. 2010
PubMed ID: 20048081
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma.
Politi K, Fan PD, Shen R, Zakowski M, Varmus H
Dis Model Mech. 2010
PubMed ID: 20007486
Biomarkers in cervical screening: quantitative reverse transcriptase PCR analysis of P16INK4a expression.
Boulet GA, Horvath CA, Depuydt CE, Bogers JJ
Eur J Cancer Prev. 2010
PubMed ID: 19910796
HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer.
Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J, Danish Head and Neck Cancer Group (DAHANCA)
Radiother Oncol. 2010
PubMed ID: 19910068
Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.
Tan JT, Ng DP, Nurbaya S, Ye S, Lim XL, Leong H, Seet LT, Siew WF, Kon W, Wong TY, Saw SM, Aung T, Chia KS, Lee J, Chew SK, Seielstad M, Tai ES
J Clin Endocrinol Metab. 2010
PubMed ID: 19892838
Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors.
Laine H, Sulg M, Kirjavainen A, Pirvola U
Dev Biol. 2010
PubMed ID: 19854167
Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions.
Anzick SL, Chen WD, Park Y, Meltzer P, Bell D, El-Naggar AK, Kaye FJ
Genes Chromosomes Cancer. 2010
PubMed ID: 19827123
Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.
Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Raeder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN
Diabetes. 2010
PubMed ID: 19794065
Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.
Borinstein SC, Conerly M, Dzieciatkowski S, Biswas S, Washington MK, Trobridge P, Henikoff S, Grady WM
Mol Carcinog. 2010
PubMed ID: 19777566
Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia.
Krieger D, Moericke A, Oschlies I, Zimmermann M, Schrappe M, Reiter A, Burkhardt B
Haematologica. 2010
PubMed ID: 19586936
p16INK4A inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos.
Andujar P, Wang J, Descatha A, Galateau-Sallé F, Abd-Alsamad I, Billon-Galland MA, Blons H, Clin B, Danel C, Housset B, Laurent-Puig P, Le Pimpec-Barthes F, Letourneux M, Monnet I, Régnard JF, Renier A, Zucman-Rossi J, Pairon JC, Jaurand MC
Lung Cancer. 2010
PubMed ID: 19375815
Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.
Zirzow S, Lüdtke TH, Brons JF, Petry M, Christoffels VM, Kispert A
Dev Biol. 2009
PubMed ID: 19769959
Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations.
Yang XR, Pfeiffer RM, Wheeler W, Yeager M, Chanock S, Tucker MA, Goldstein AM
Int J Cancer. 2009
PubMed ID: 19626699
Expression of p16 protein in acral lentiginous melanoma.
Hsieh R, Firmiano A, Sotto MN
Int J Dermatol. 2009
PubMed ID: 20415670
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Correlation between histological type and immunohistochemical profile of prostate cancer and gleason scale gradation.
Iemelynova AA, Grygorenko VM, Cheremuha SV, Romanenko AM
Exp Oncol. 2009
PubMed ID: 20010526
Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors.
Avanzini MA, Bernardo ME, Cometa AM, Perotti C, Zaffaroni N, Novara F, Visai L, Moretta A, Del Fante C, Villa R, Ball LM, Fibbe WE, Maccario R, Locatelli F
Haematologica. 2009
PubMed ID: 19773264
Functional impairment of p16(INK4A) due to CDKN2A p.Gly23Asp missense mutation.
Scaini MC, Rossi E, de Siqueira Torres PL, Zullato D, Callegaro M, Casella C, Quaggio M, Agata S, Malacrida S, Chiarion-Sileni V, Vecchiato A, Alaibac M, Montagna M, Mann GJ, Menin C, D'Andrea E
Mutat Res. 2009
PubMed ID: 19712690
Aberrant promoter methylation and reduced expression of p16 gene in esophageal squamous cell carcinoma from Kashmir valley: a high-risk area.
Salam I, Hussain S, Mir MM, Dar NA, Abdullah S, Siddiqi MA, Lone RA, Zargar SA, Sharma S, Hedau S, Basir SF, Bharti AC, Das BC
Mol Cell Biochem. 2009
PubMed ID: 19513816
RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
Lin Q, Geng J, Ma K, Yu J, Sun J, Shen Z, Bao G, Chen Y, Zhang H, He Y, Luo X, Feng X, Zhu J
J Cancer Res Clin Oncol. 2009
PubMed ID: 19506903
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.
Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T
Cancer Cell. 2009
PubMed ID: 19878870
p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2.
Obexer P, Hagenbuchner J, Rupp M, Salvador C, Holzner M, Deutsch M, Porto V, Kofler R, Unterkircher T, Ausserlechner MJ
J Biol Chem. 2009
PubMed ID: 19737931
miR-290 acts as a physiological effector of senescence in mouse embryo fibroblasts.
Pitto L, Rizzo M, Simili M, Colligiani D, Evangelista M, Mercatanti A, Mariani L, Cremisi F, Rainaldi G
Physiol Genomics. 2009
PubMed ID: 19723773
Paradoxical down-regulation of p16 mRNA with advancing age in acute myeloid leukemia.
de Jonge HJ, Woolthuis CM, de Bont ES, Huls G
Aging (Albany NY). 2009
PubMed ID: 20157576
Numerical abnormalities of chromosome 9 and p16CDKN2A gene deletion detected by FISH in non-small cell lung cancer.
Panani AD, Maliaga K, Babanaraki A, Bellenis I
Anticancer Res. 2009
PubMed ID: 20032395
Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma.
Altavilla G, Staffieri A, Busatto G, Canesso A, Giacomelli L, Marioni G
Acta Otolaryngol. 2009
PubMed ID: 19863319
Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A, p53, Ki-67, estrogen receptors, and progesterone receptors.
Sung CO, Ahn G, Song SY, Choi YL, Bae DS
Int J Gynecol Pathol. 2009
PubMed ID: 19851199
Comparative analysis of P16 and P53 expression in uterine malignant mixed mullerian tumors.
Buza N, Tavassoli FA
Int J Gynecol Pathol. 2009
PubMed ID: 19851197
p16(INK4a) expression analysis as an ancillary tool for cytologic diagnosis of urothelial carcinoma.
Nakazawa K, Murata S, Yuminamochi T, Ishii Y, Ohno S, Nakazawa T, Kondo T, Katoh R
Am J Clin Pathol. 2009
PubMed ID: 19846821
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.
Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB, Largaespada DA
Cancer Res. 2009
PubMed ID: 19843846
Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study.
Kim M, Yim SH, Cho NS, Kang SH, Ko DH, Oh B, Kim TY, Min HJ, She CJ, Kang HJ, Shin HY, Ahn HS, Yoon SS, Kim BK, Shin HR, Han KS, Cho HI, Lee DS
Cancer Genet Cytogenet. 2009
PubMed ID: 19837270
Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation.
Vivo M, Di Costanzo A, Fortugno P, Pollice A, Calabrò V, La Mantia G
Cell Cycle. 2009
PubMed ID: 19829080
Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers.
Yoshino M, Suzuki M, Tian L, Moriya Y, Hoshino H, Okamoto T, Yoshida S, Shibuya K, Yoshino I
Int J Oncol. 2009
PubMed ID: 19787276
Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells.
Meng CF, Zhu XJ, Peng G, Dai DQ
Oncol Rep. 2009
PubMed ID: 19787243
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers.
Bellizzi AM, Woodford RL, Moskaluk CA, Jones DR, Kozower BD, Stelow EB
Am J Surg Pathol. 2009
PubMed ID: 19738459
Promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions.
Zou XP, Zhang B, Zhang XQ, Chen M, Cao J, Liu WJ
Hum Pathol. 2009
PubMed ID: 19695681
Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta.
Takahashi H, Toyoda M, Birumachi J, Horie A, Uyama T, Miyado K, Matsumoto K, Saito H, Umezawa A
J Cell Physiol. 2009
PubMed ID: 19582773
Correlation of p53, MDM2 and p14(ARF) protein expression in human esophageal squamous cell carcinoma.
Cheng TH, Hsu PK, Li AF, Hung IC, Huang MH, Hsu HS
J Cancer Res Clin Oncol. 2009
PubMed ID: 19488782
Significance of promoter hypermethylation of p16 gene for margin assessment in carcinoma tongue.
Sinha P, Bahadur S, Thakar A, Matta A, Macha M, Ralhan R, Gupta SD
Head Neck. 2009
PubMed ID: 19431196
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL
Br J Cancer. 2009
PubMed ID: 19738611
In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laser.
Galanzha EI, Shashkov EV, Spring PM, Suen JY, Zharov VP
Cancer Res. 2009
PubMed ID: 19826056
Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.
Akbari MR, Malekzadeh R, Shakeri R, Nasrollahzadeh D, Foumani M, Sun Y, Pourshams A, Sadjadi A, Jafari E, Sotoudeh M, Kamangar F, Boffetta P, Dawsey SM, Ghadirian P, Narod SA
Cancer Res. 2009
PubMed ID: 19826048
Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.
Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada J, Hirao A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805150
Genome integrity: linking pluripotency and tumorgenicity.
Deng W, Xu Y
Trends Genet. 2009
PubMed ID: 19801173
A germline mutation of p14/ARF in a melanoma kindred.
Garcia-Casado Z, Nagore E, Fernandez-Serra A, Botella-Estrada R, Lopez-Guerrero JA
Melanoma Res. 2009
PubMed ID: 19741424
AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance.
de Jonge HJ, de Bont ES, Valk PJ, Schuringa JJ, Kies M, Woolthuis CM, Delwel R, Veeger NJ, Vellenga E, Löwenberg B, Huls G
Blood. 2009
PubMed ID: 19667402
Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases.
Yemelyanova A, Ji H, Shih IeM, Wang TL, Wu LS, Ronnett BM
Am J Surg Pathol. 2009
PubMed ID: 19623034
A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis.
Woolfenden S, Zhu H, Charest A
Genesis. 2009
PubMed ID: 19603508
Association of genetic polymorphisms in GADD45A, MDM2, and p14 ARF with the risk of chronic benzene poisoning in a Chinese occupational population.
Sun P, Zhang Z, Wan J, Zhao N, Jin X, Xia Z
Toxicol Appl Pharmacol. 2009
PubMed ID: 19596022
Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene.
Zhao J, Li M, Bradfield JP, Wang K, Zhang H, Sleiman P, Kim CE, Annaiah K, Glaberson W, Glessner JT, Otieno FG, Thomas KA, Garris M, Hou C, Frackelton EC, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SF
Diabetes. 2009
PubMed ID: 19592620
Different molecular mechanisms causing 9p21 deletions in acute lymphoblastic leukemia of childhood.
Novara F, Beri S, Bernardo ME, Bellazzi R, Malovini A, Ciccone R, Cometa AM, Locatelli F, Giorda R, Zuffardi O
Hum Genet. 2009
PubMed ID: 19484265
IGFBP2 is a candidate biomarker for Ink4a-Arf status and a therapeutic target for high-grade gliomas.
Moore LM, Holmes KM, Smith SM, Wu Y, Tchougounova E, Uhrbom L, Sawaya R, Bruner JM, Fuller GN, Zhang W
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805356
A quantitative model for age-dependent expression of the p16INK4a tumor suppressor.
Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805338
Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
Kang ES, Kim MS, Kim CH, Nam CM, Han SJ, Hur KY, Ahn CW, Cha BS, Kim SI, Lee HC, Kim YS
Transplantation. 2009
PubMed ID: 19741467
Adding the p16(INK4a) marker to the traditional 3-marker (ER/Vim/CEA) panel engenders no supplemental benefit in distinguishing between primary endocervical and endometrial adenocarcinomas in a tissue microarray study.
Han CP, Lee MY, Kok LF, Ruan A, Wu TS, Cheng YW, Tyan YS, Lin CY
Int J Gynecol Pathol. 2009
PubMed ID: 19696622
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.
McWilliams RR, Bamlet WR, de Andrade M, Rider DN, Couch FJ, Cunningham JM, Matsumoto ME, Rabe KG, Hammer TJ, Petersen GM
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19690177
Effect of human papillomavirus on cell cycle-related proteins p16, Ki-67, Cyclin D1, p53, and ProEx C in precursor lesions of cervical carcinoma: a tissue microarray study.
Conesa-Zamora P, Doménech-Peris A, Orantes-Casado FJ, Ortiz-Reina S, Sahuquillo-Frías L, Acosta-Ortega J, García-Solano J, Pérez-Guillermo M
Am J Clin Pathol. 2009
PubMed ID: 19687314
ETV6-RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis.
Emerenciano M, Bungaro S, Cazzaniga G, Dorea MD, Coser VM, Magalhães IQ, Biondi A, Pombo-de-Oliveira MS
Cancer Genet Cytogenet. 2009
PubMed ID: 19665068
ARF stimulates XPC to trigger nucleotide excision repair by regulating the repressor complex of E2F4.
Dominguez-Brauer C, Chen YJ, Brauer PM, Pimkina J, Raychaudhuri P
EMBO Rep. 2009
PubMed ID: 19644500
Low p14ARF expression in de novo acute myeloid leukemia with normal karyotype is associated with poor survival.
Paul E, Paul E, Uggla B, Deneberg S, Bengtzen S, Hermansson M, Dahlman I, Rosenquist R, Wiman KG, Nahi H
Leuk Lymphoma. 2009
PubMed ID: 19626541
Underlying genetic models of inheritance in established type 2 diabetes associations.
Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM, Grallert H, Grarup N, Groop L, Hansen T, Hattersley AT, Hu FB, Hveem K, Illig T, Kuusisto J, Laakso M, Langenberg C, Lyssenko V, McCarthy MI, Morris A, Morris AD, Palmer CN, Payne F, Platou CG, Scott LJ, Voight BF, Wareham NJ, Zeggini E, Ioannidis JP
Am J Epidemiol. 2009
PubMed ID: 19602701
Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value.
Jardin F, Picquenot JM, Parmentier F, Ruminy P, Cornic M, Penther D, Bertrand P, Lanic H, Cassuto O, Humbrecht C, Lemasle E, Wautier A, Bastard C, Tilly H
Br J Haematol. 2009
PubMed ID: 19594747
DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus.
Wang JS, Guo M, Montgomery EA, Thompson RE, Cosby H, Hicks L, Wang S, Herman JG, Canto MI
Am J Gastroenterol. 2009
PubMed ID: 19584833
CDKN2A mutations in melanoma families from Uruguay.
Larre Borges A, Borges AL, Cuéllar F, Puig-Butillé JA, Scarone M, Delgado L, Badenas C, Milà M, Malvehy J, Barquet V, Núñez J, Laporte M, Fernández G, Levrero P, Martínez-Asuaga M, Puig S
Br J Dermatol. 2009
PubMed ID: 19523171
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol. 2009
PubMed ID: 19465901
Absence of methylation-dependent transcriptional silencing in TP73 irrespective of the methylation status of the CDKN2A CpG island in plasma cell neoplasia.
Hatzimichael E, Benetatos L, Dasoula A, Dranitsaris G, Tsiara S, Georgiou I, Syrrou M, Stebbing J, Coley HM, Crook T, Bourantas KL
Leuk Res. 2009
PubMed ID: 19423161
DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components.
Kubo T, Yamamoto H, Ichimura K, Jida M, Hayashi T, Otani H, Tsukuda K, Sano Y, Kiura K, Toyooka S
Lung Cancer. 2009
PubMed ID: 19144441
Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro.
Schrage YM, Lam S, Jochemsen AG, Cleton-Jansen AM, Taminiau AH, Hogendoorn PC, Bovée JV
J Cell Mol Med. 2009
PubMed ID: 18624751
Use of Multiple Metabolic and Genetic Markers to Improve the Prediction of Type 2 Diabetes: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study.
Schulze MB, Weikert C, Pischon T, Bergmann MM, Al-Hasani H, Schleicher E, Fritsche A, Häring HU, Boeing H, Joost HG
Diabetes Care. 2009
PubMed ID: 19720844
Mutational analysis of CDKN2A gene in a group of 390 larynx cancer patients.
Kiwerska K, Rydzanicz M, Kram A, Pastok M, Antkowiak A, Domagała W, Szyfter K
Mol Biol Rep. 2009
PubMed ID: 19690981
Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome.
Chen J, Etzel CJ, Amos CI, Zhang Q, Viscofsky N, Lindor NM, Lynch PM, Frazier ML
Cancer Causes Control. 2009
PubMed ID: 19690970
Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study.
Cao J, Zhou J, Gao Y, Gu L, Meng H, Liu H, Deng D
Clin Cancer Res. 2009
PubMed ID: 19671846
Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning.
Hinshelwood RA, Melki JR, Huschtscha LI, Paul C, Song JZ, Stirzaker C, Reddel RR, Clark SJ
Hum Mol Genet. 2009
PubMed ID: 19477956
Genetic variants on chromosome 9p21 and ischemic stroke in Chinese.
Hu WL, Li SJ, Liu DT, Wang Y, Niu SQ, Yang XC, Zhang Q, Yu SZ, Jin L, Wang XF
Brain Res Bull. 2009
PubMed ID: 19559344
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.
Yamakoshi K, Takahashi A, Hirota F, Nakayama R, Ishimaru N, Kubo Y, Mann DJ, Ohmura M, Hirao A, Saya H, Arase S, Hayashi Y, Nakao K, Matsumoto M, Ohtani N, Hara E
J Cell Biol. 2009
PubMed ID: 19667129
Targeted activation of innate immunity for therapeutic induction of autophagy and apoptosis in melanoma cells.
Tormo D, Checińska A, Alonso-Curbelo D, Pérez-Guijarro E, Cañón E, Riveiro-Falkenbach E, Calvo TG, Larribere L, Megías D, Mulero F, Piris MA, Dash R, Barral PM, Rodríguez-Peralto JL, Ortiz-Romero P, Tüting T, Fisher PB, Soengas MS
Cancer Cell. 2009
PubMed ID: 19647221
Vitamin D receptor variants and the malignant melanoma risk: a population-based study.
Gapska P, Scott RJ, Serrano-Fernandez P, Mirecka A, Rassoud I, Górski B, Cybulski C, Huzarski T, Byrski T, Nagay L, Maleszka R, Sulikowski M, Lubinski J, Debniak T
Cancer Epidemiol. 2009
PubMed ID: 19679055
Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo.
Chen Z, Lin Y, Barbieri E, Burlingame S, Hicks J, Ludwig A, Shohet JM
Neoplasia. 2009
PubMed ID: 19649205
Mutational analysis of TP53, PTEN, PIK3CA and CTNNB1/beta-catenin genes in human herpesvirus 8-associated primary effusion lymphoma.
Boulanger E, Marchio A, Hong SS, Pineau P
Haematologica. 2009
PubMed ID: 19608668
Genome-wide association study identifies five susceptibility loci for glioma.
Shete S, Hosking FJ, Robertson LB, Dobbins SE, Sanson M, Malmer B, Simon M, Marie Y, Boisselier B, Delattre JY, Hoang-Xuan K, El Hallani S, Idbaih A, Zelenika D, Andersson U, Henriksson R, Bergenheim AT, Feychting M, Lönn S, Ahlbom A, Schramm J, Linnebank M, Hemminki K, Kumar R, Hepworth SJ, Price A, Armstrong G, Liu Y, Gu X, Yu R, Lau C, Schoemaker M, Muir K, Swerdlow A, Lathrop M, Bondy M, Houlston RS
Nat Genet. 2009
PubMed ID: 19578367
Genome-wide association study identifies three loci associated with melanoma risk.
Bishop DT, Demenais F, Iles MM, Harland M, Taylor JC, Corda E, Randerson-Moor J, Aitken JF, Avril MF, Azizi E, Bakker B, Bianchi-Scarrà G, Bressac-de Paillerets B, Calista D, Cannon-Albright LA, Chin-A-Woeng T, Debniak T, Galore-Haskel G, Ghiorzo P, Gut I, Hansson J, Hocevar M, Höiom V, Hopper JL, Ingvar C, Kanetsky PA, Kefford RF, Landi MT, Lang J, Lubiński J, Mackie R, Malvehy J, Mann GJ, Martin NG, Montgomery GW, van Nieuwpoort FA, Novakovic S, Olsson H, Puig S, Weiss M, van Workum W, Zelenika D, Brown KM, Goldstein AM, Gillanders EM, Boland A, Galan P, Elder DE, Gruis NA, Hayward NK, Lathrop GM, Barrett JH, Bishop JA
Nat Genet. 2009
PubMed ID: 19578364
New common variants affecting susceptibility to basal cell carcinoma.
Stacey SN, Sulem P, Masson G, Gudjonsson SA, Thorleifsson G, Jakobsdottir M, Sigurdsson A, Gudbjartsson DF, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Scherer D, Hemminki K, Rudnai P, Gurzau E, Koppova K, Botella-Estrada R, Soriano V, Juberias P, Saez B, Gilaberte Y, Fuentelsaz V, Corredera C, Grasa M, Höiom V, Lindblom A, Bonenkamp JJ, van Rossum MM, Aben KK, de Vries E, Santinami M, Di Mauro MG, Maurichi A, Wendt J, Hochleitner P, Pehamberger H, Gudmundsson J, Magnusdottir DN, Gretarsdottir S, Holm H, Steinthorsdottir V, Frigge ML, Blondal T, Saemundsdottir J, Bjarnason H, Kristjansson K, Bjornsdottir G, Okamoto I, Rivoltini L, Rodolfo M, Kiemeney LA, Hansson J, Nagore E, Mayordomo JI, Kumar R, Karagas MR, Nelson HH, Gulcher JR, Rafnar T, Thorsteinsdottir U, Olafsson JH, Kong A, Stefansson K
Nat Genet. 2009
PubMed ID: 19578363
Germline mutations in CDKN2A are infrequent in female patients with melanoma and breast cancer.
Nagore E, Montoro A, García-Casado Z, Botella-Estrada R, Insa A, Lluch A, López-Guerrero JA, Guillén C
Melanoma Res. 2009
PubMed ID: 19571771
Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts.
Zhou R, Han L, Li G, Tong T
Nucleic Acids Res. 2009
PubMed ID: 19561196
Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging.
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, Thomas NE, Sharpless NE
Aging Cell. 2009
PubMed ID: 19485966
MS-qFRET: a quantum dot-based method for analysis of DNA methylation.
Bailey VJ, Easwaran H, Zhang Y, Griffiths E, Belinsky SA, Herman JG, Baylin SB, Carraway HE, Wang TH
Genome Res. 2009
PubMed ID: 19443857
Met amplification and tumor progression in Cdkn2a-deficient melanocytes.
Vanbrocklin MW, Robinson JP, Whitwam T, Guilbeault AR, Koeman J, Swiatek PJ, Vande Woude GF, Khoury JD, Holmen SL
Pigment Cell Melanoma Res. 2009
PubMed ID: 19422607
Differential gene expression in young and senescent endothelial cells under static and laminar shear stress conditions.
Mun GI, Lee SJ, An SM, Kim IK, Boo YC
Free Radic Biol Med. 2009
PubMed ID: 19409979
Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.
Haferkamp S, Scurr LL, Becker TM, Frausto M, Kefford RF, Rizos H
J Invest Dermatol. 2009
PubMed ID: 19212341
Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer.
Vallian S, Sedaghat M, Nassiri I, Frazmand A
J Cancer Res Clin Oncol. 2009
PubMed ID: 19125298
Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre-)malignant squamous skin tumours.
Küsters-Vandevelde HV, de Koning MN, Melchers WJ, Quint WG, de Wilde PC, de Jong EM, van de Kerkhof PC, Blokx WA
J Cell Mol Med. 2009
PubMed ID: 18681909
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
p16INK4a expression in cytology of ascites and response to chemotherapy in advanced ovarian cancer.
Goto T, Takano M, Hirata J, Kohno T, Ohtsuka S, Fujiwara K, Tsuda H
Int J Cancer. 2009
PubMed ID: 19330839
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf.
Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER
EMBO J. 2009
PubMed ID: 19494829
Id1 is down-regulated by hepatocyte growth factor via ERK-dependent and ERK-independent signaling pathways, leading to increased expression of p16INK4a in hepatoma cells.
Ushio K, Hashimoto T, Kitamura N, Tanaka T
Mol Cancer Res. 2009
PubMed ID: 19567783
Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology.
Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19567510
p16 expression differentiates between desmoplastic Spitz nevus and desmoplastic melanoma.
Hilliard NJ, Krahl D, Sellheyer K
J Cutan Pathol. 2009
PubMed ID: 19519606
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N, Nawata H, Nakamura J, Kono S, Takayanagi R, Kato N
Diabetes. 2009
PubMed ID: 19401414
ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation.
Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, Menendez S, Nimer SD
Mol Cell Biol. 2009
PubMed ID: 19380490
p16 INK4A is a strong biomarker for cervical intraepithelial neoplasia and invasive cervical carcinoma: a reappraisal.
Haidopoulos D, Partsinevelos GA, Vlachos GD, Rodolakis A, Markaki S, Voulgaris Z, Diakomanolis E, Antsaklis A
Reprod Sci. 2009
PubMed ID: 19372590
MTAP and CDKN2B genes are associated with myocardial infarction in Chinese Hans.
Yang XC, Zhang Q, Chen ML, Li Q, Yang ZS, Li L, Cao FF, Chen XD, Liu WJ, Jin L, Wang XF
Clin Biochem. 2009
PubMed ID: 19272367
Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT.
Daniotti M, Ferrari A, Frigerio S, Casieri P, Miselli F, Zucca E, Collini P, Della Torre G, Manoukian S, Peissel B, Bono A, Santinami M, Parmiani G, Rivoltini L, Pilotti S, Rodolfo M
J Invest Dermatol. 2009
PubMed ID: 19158841
Expression of Galectin-3, CD138, p16INK4a, and TTF-1 in mucinous bronchioloalveolar adenocarcinoma after Hodgkin lymphoma.
Al-Salam S, Al-Ashari M
Appl Immunohistochem Mol Morphol. 2009
PubMed ID: 18997617
The role of deeper levels and ancillary studies (p16(Ink4a) and ProExC) in reducing the discordance rate of Papanicolaou findings of high-grade squamous intraepithelial lesion and follow-up cervical biopsies.
David O, Cabay RJ, Pasha S, Dietrich R, Leach L, Guo M, Mehrotra S
Cancer Cytopathol. 2009
PubMed ID: 19521978
Endogenous tumor suppression mediated by PTEN involves survivin gene silencing.
Guha M, Plescia J, Leav I, Li J, Languino LR, Altieri DC
Cancer Res. 2009
PubMed ID: 19470765
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK
Cell. 2009
PubMed ID: 19524511
Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice.
Goel VK, Ibrahim N, Jiang G, Singhal M, Fee S, Flotte T, Westmoreland S, Haluska FS, Hinds PW, Haluska FG
Oncogene. 2009
PubMed ID: 19398955
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model.
Cullion K, Draheim KM, Hermance N, Tammam J, Sharma VM, Ware C, Nikov G, Krishnamoorthy V, Majumder PK, Kelliher MA
Blood. 2009
PubMed ID: 19246562
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study.
Junyent M, Tucker KL, Shen J, Lee YC, Smith CE, Mattei J, Lai CQ, Parnell LD, Ordovas JM
Nutr Metab Cardiovasc Dis. 2009
PubMed ID: 19501493
Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.
Attema JL, Pronk CJ, Norddahl GL, Nygren JM, Bryder D
Oncogene. 2009
PubMed ID: 19398954
Clinical genetic testing for familial melanoma in Italy: A cooperative study.
Bruno W, Ghiorzo P, Battistuzzi L, Ascierto PA, Barile M, Gargiulo S, Gensini F, Gliori S, Guida M, Lombardo M, Manoukian S, Menin C, Nasti S, Origone P, Pasini B, Pastorino L, Peissel B, Pizzichetta MA, Queirolo P, Rodolfo M, Romanini A, Scaini MC, Testori A, Tibiletti MG, Turchetti D, Leachman SA, Scarra GB, on behalf of IMI, the Italian Melanoma Intergroup
J Am Acad Dermatol. 2009
PubMed ID: 19500876
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardeesy N, Settleman J
Cancer Cell. 2009
PubMed ID: 19477428
Increased protein expression of p16 and cyclin D1 in squamous cell carcinoma tissues.
Eshkoor SA, Ismail P, Rahman SA, Mirinargesi M, Oshkour SA
Biosci Trends. 2009
PubMed ID: 20103831
[Hepatitis B virus X protein inhibits hepatoma cell growth in vitro through p14(ARF)-dependent and p14(ARF)-independent pathways]
Yu DH, Lin J, Qu JH, Zhu Z, Li FM, Ni CR, Zhu MH
Nan Fang Yi Ke Da Xue Xue Bao. 2009
PubMed ID: 19726330
[Estimation of the methylation status of the promoter region of the cell cycle gene P14ARF in placental tissues of spontaneous abortuses with chromosomal mosaicism]
Kashevarova AA, Tolmacheva EN, Sukhanova NN, Sazhenova EA, Lebedev IN
Genetika. 2009
PubMed ID: 19639877
Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development.
Freeman-Anderson NE, Zheng Y, McCalla-Martin AC, Treanor LM, Zhao YD, Garfin PM, He TC, Mary MN, Thornton JD, Anderson C, Gibbons M, Saab R, Baumer SH, Cunningham JM, Skapek SX
Development. 2009
PubMed ID: 19465598
p16 expression in conventional and desmoplastic trichilemmomas.
Hilliard NJ, Wakefield DN, Krahl D, Sellheyer K
Am J Dermatopathol. 2009
PubMed ID: 19461237
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Scoring of p16(INK4a) immunohistochemistry based on independent nuclear staining alone can sufficiently distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study.
Han CP, Kok LF, Wang PH, Wu TS, Tyan YS, Cheng YW, Lee MY, Yang SF
Mod Pathol. 2009
PubMed ID: 19347018
CDKN2A and MC1R analysis in amelanotic and pigmented melanoma.
Ghiorzo P, Pastorino L, Pizzichetta MA, Bono R, Queirolo P, Talamini R, Annessi G, Bruno W, Nasti S, Gargiulo S, Battistuzzi L, Sini MC, Palmieri G, Scarrà GB, Italian Melanoma Intergroup
Melanoma Res. 2009
PubMed ID: 19339902
Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
Brito EC, Lyssenko V, Renström F, Berglund G, Nilsson PM, Groop L, Franks PW
Diabetes. 2009
PubMed ID: 19324937
Deregulation of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in basal cell carcinoma.
Kanellou P, Zaravinos A, Zioga M, Spandidos DA
Br J Dermatol. 2009
PubMed ID: 19298278
Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.
van Hoek M, Langendonk JG, de Rooij SR, Sijbrands EJ, Roseboom TJ
Diabetes. 2009
PubMed ID: 19258437
Type 2 diabetes risk alleles are associated with reduced size at birth.
Freathy RM, Bennett AJ, Ring SM, Shields B, Groves CJ, Timpson NJ, Weedon MN, Zeggini E, Lindgren CM, Lango H, Perry JR, Pouta A, Ruokonen A, Hyppönen E, Power C, Elliott P, Strachan DP, Järvelin MR, Smith GD, McCarthy MI, Frayling TM, Hattersley AT
Diabetes. 2009
PubMed ID: 19228808
Preferentially different mechanisms of inactivation of 9p21 gene cluster in liver fluke-related cholangiocarcinoma.
Chinnasri P, Pairojkul C, Jearanaikoon P, Sripa B, Bhudhisawasdi V, Tantimavanich S, Limpaiboon T
Hum Pathol. 2009
PubMed ID: 19200577
Protective effect of copy number polymorphism of glutathione S-transferase T1 gene on melanoma risk in presence of CDKN2A mutations, MC1R variants and host-related phenotypes.
Chaudru V, Lo MT, Lesueur F, Marian C, Mohamdi H, Laud K, Barrois M, Chompret A, Avril MF, Demenais F, Paillerets BB
Fam Cancer. 2009
PubMed ID: 19484507
Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes.
Kim J, Wong PK
J Biol Chem. 2009
PubMed ID: 19321450
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.
Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K
Genes Dev. 2009
PubMed ID: 19451217
Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.
Witcher M, Emerson BM
Mol Cell. 2009
PubMed ID: 19450526
Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen.
Rahrmann EP, Collier LS, Knutson TP, Doyal ME, Kuslak SL, Green LE, Malinowski RL, Roethe L, Akagi K, Waknitz M, Huang W, Largaespada DA, Marker PC
Cancer Res. 2009
PubMed ID: 19401450
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Abnormal expression of c-myc, p53, p16 protein and GNAS1 gene mutation in fibrous dysplasia].
Tang J, Zhao HY, Zheng L, Zhang HZ, Jiang ZM
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 19575869
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
Amosenko FA, Kazubskaia TP, Gromyko OE, Matveeva TI, Korchagina EL, Nasedkina TV, Gar'kavtseva RF, Kalinin VN
Mol Biol (Mosk). 2009
PubMed ID: 19548527
p16ink4a is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus.
Lakshmi S, Rema P, Somanathan T
Pathobiology. 2009
PubMed ID: 19468254
Identification of aberrant cell cycle regulation in Epstein-Barr virus-associated nasopharyngeal carcinoma by cDNA microarray and gene set enrichment analysis.
Zhang W, Zeng Z, Zhou Y, Xiong W, Fan S, Xiao L, Huang D, Li Z, Li D, Wu M, Li X, Shen S, Wang R, Cao L, Tang K, Li G
Acta Biochim Biophys Sin (Shanghai). 2009
PubMed ID: 19430707
Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas.
Kuo KT, Guan B, Feng Y, Mao TL, Chen X, Jinawath N, Wang Y, Kurman RJ, Shih IeM, Wang TL
Cancer Res. 2009
PubMed ID: 19383911
Utility of p16 immunohistochemistry for the identification of Lynch syndrome.
Payá A, Alenda C, Pérez-Carbonell L, Rojas E, Soto JL, Guillén C, Castillejo A, Barberá VM, Carrato A, Castells A, Llor X, Andreu M, Koh J, Enders GH, Benlloch S, Jover R
Clin Cancer Res. 2009
PubMed ID: 19383812
Usefulness of p16 for differentiating primary pulmonary squamous cell carcinoma from cervical squamous cell carcinoma metastatic to the lung.
Wang CW, Wu TI, Yu CT, Wu YC, Teng YH, Chin SY, Lai CH, Chen TC
Am J Clin Pathol. 2009
PubMed ID: 19369633
Contribution of genetic factors for melanoma susceptibility in sporadic US melanoma patients.
Council ML, Gardner JM, Helms C, Liu Y, Cornelius LA, Bowcock AM
Exp Dermatol. 2009
PubMed ID: 19320745
Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.
Bruggeman SW, Hulsman D, van Lohuizen M
Biochim Biophys Acta. 2009
PubMed ID: 19298843
Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.
Qi L, Cornelis MC, Zhang C, van Dam RM, Hu FB
Am J Clin Nutr. 2009
PubMed ID: 19279076
BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells.
Su D, Zhu S, Han X, Feng Y, Huang H, Ren G, Pan L, Zhang Y, Lu J, Huang B
J Biol Chem. 2009
PubMed ID: 19269967
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes.
Pulizzi N, Lyssenko V, Jonsson A, Osmond C, Laakso M, Kajantie E, Barker DJ, Groop LC, Eriksson JG
Diabetologia. 2009
PubMed ID: 19225753
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-alpha via the p38 mitogen-activated protein kinase pathway.
Zhang Y, Herbert BS, Rajashekhar G, Ingram DA, Yoder MC, Clauss M, Rehman J
FASEB J. 2009
PubMed ID: 19124561
Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large B-cell lymphoma, leg type.
Senff NJ, Zoutman WH, Vermeer MH, Assaf C, Berti E, Cerroni L, Espinet B, de Misa Cabrera RF, Geerts ML, Kempf W, Mitchell TJ, Paulli M, Petrella T, Pimpinelli N, Santucci M, Whittaker SJ, Willemze R, Tensen CP
J Invest Dermatol. 2009
PubMed ID: 19020554
p16(INK4A) immunohistochemical staining may be helpful in distinguishing branchial cleft cysts from cystic squamous cell carcinomas originating in the oropharynx.
Pai RK, Erickson J, Pourmand N, Kong CS
Cancer Cytopathol. 2009
PubMed ID: 19365840
Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.
Cornelis MC, Qi L, Zhang C, Kraft P, Manson J, Cai T, Hunter DJ, Hu FB
Ann Intern Med. 2009
PubMed ID: 19380854
Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck.
Lassen P, Eriksen JG, Hamilton-Dutoit S, Tramm T, Alsner J, Overgaard J
J Clin Oncol. 2009
PubMed ID: 19289615
Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.
He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ
Dev Biol. 2009
PubMed ID: 19389366
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities.
di Tommaso A, Hagen J, Tompkins V, Muniz V, Dudakovic A, Kitzis A, Ladeveze V, Quelle DE
Exp Cell Res. 2009
PubMed ID: 19331830
Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice.
Gromley A, Churchman ML, Zindy F, Sherr CJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19339492
Oncogenic Braf induces melanocyte senescence and melanoma in mice.
Dhomen N, Reis-Filho JS, da Rocha Dias S, Hayward R, Savage K, Delmas V, Larue L, Pritchard C, Marais R
Cancer Cell. 2009
PubMed ID: 19345328
Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.
Shamma A, Takegami Y, Miki T, Kitajima S, Noda M, Obara T, Okamoto T, Takahashi C
Cancer Cell. 2009
PubMed ID: 19345325
Gene mutations in esophageal mucosa of chagas disease patients.
DA Silva Manoel-Caetano F, Silveira AF, Silva AE
Anticancer Res. 2009
PubMed ID: 19414370
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P
Cancer Res. 2009
PubMed ID: 19339270
Credentialing a preclinical mouse model of alveolar rhabdomyosarcoma.
Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C
Cancer Res. 2009
PubMed ID: 19339268
Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells.
Rodriguez R, Rubio R, Masip M, Catalina P, Nieto A, de la Cueva T, Arriero M, San Martin N, de la Cueva E, Balomenos D, Menendez P, García-Castro J
Neoplasia. 2009
PubMed ID: 19308294
The myocardial infarction associated CDKN2A/CDKN2B locus on chromosome 9p21 is associated with stroke independently of coronary events in patients with hypertension.
Wahlstrand B, Orho-Melander M, Delling L, Kjeldsen S, Narkiewicz K, Almgren P, Hedner T, Melander O
J Hypertens. 2009
PubMed ID: 19293724
Involvement of p16 and PTCH in pathogenesis of melanoma and basal cell carcinoma.
Cretnik M, Poje G, Musani V, Kruslin B, Ozretic P, Tomas D, Situm M, Levanat S
Int J Oncol. 2009
PubMed ID: 19287961
Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.
Kannengiesser C, Brookes S, del Arroyo AG, Pham D, Bombled J, Barrois M, Mauffret O, Avril MF, Chompret A, Lenoir GM, Sarasin A, French Hereditary Melanoma Study Group, Peters G, Bressac-de Paillerets B
Hum Mutat. 2009
PubMed ID: 19260062
Large CTG repeats trigger p16-dependent premature senescence in myotonic dystrophy type 1 muscle precursor cells.
Bigot A, Klein AF, Gasnier E, Jacquemin V, Ravassard P, Butler-Browne G, Mouly V, Furling D
Am J Pathol. 2009
PubMed ID: 19246640
Anti-aging activity of the Ink4/Arf locus.
Matheu A, Maraver A, Collado M, Garcia-Cao I, Cañamero M, Borras C, Flores JM, Klatt P, Viña J, Serrano M
Aging Cell. 2009
PubMed ID: 19239418
Identification of a CDK4 R24H mutation-positive melanoma family by analysis of early-onset melanoma patients in Latvia.
Pjanova D, Molven A, Akslen LA, Engele L, Streinerte B, Azarjana K, Heisele O
Melanoma Res. 2009
PubMed ID: 19238106
Genotype and haplotype analysis of cell cycle genes in sporadic colorectal cancer in the Czech Republic.
Polakova V, Pardini B, Naccarati A, Landi S, Slyskova J, Novotny J, Vodickova L, Bermejo JL, Hanova M, Smerhovsky Z, Tulupova E, Kumar R, Hemminki K, Vodicka P
Hum Mutat. 2009
PubMed ID: 19224585
Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study.
Lin X, Song K, Lim N, Yuan X, Johnson T, Abderrahmani A, Vollenweider P, Stirnadel H, Sundseth SS, Lai E, Burns DK, Middleton LT, Roses AD, Matthews PM, Waeber G, Cardon L, Waterworth DM, Mooser V
Diabetologia. 2009
PubMed ID: 19139842
Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence.
Tchougounova E, Jiang Y, Bråsäter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L
Oncogene. 2009
PubMed ID: 19219070
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.
Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19246386
Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice.
Altomare DA, Menges CW, Pei J, Zhang L, Skele-Stump KL, Carbone M, Kane AB, Testa JR
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19223589
[The expression of PTEN and P16 protein in nasal inverted papilloma].
Zhao J, Wang Y, Kong W
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009
PubMed ID: 19522184
Biomarker p16(INK4a) on paraffin sections prepared from cervical brush samples highlights nuclear changes resulting in unquestionable cytohistodiagnosis.
Brons-Holloway PA, Risse EK, Meijer-Marres EM, Duineveld SM, Ouwerkerk-Noordam E, Boon ME
Acta Cytol. 2009
PubMed ID: 19365965
Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
Goode EL, Fridley BL, Vierkant RA, Cunningham JM, Phelan CM, Anderson S, Rider DN, White KL, Pankratz VS, Song H, Hogdall E, Kjaer SK, Whittemore AS, DiCioccio R, Ramus SJ, Gayther SA, Schildkraut JM, Pharaoh PP, Sellers TA
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19258477
CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis.
Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, Ibarra-Drendall C, Ostrander JH, D'Amato NC, Zalles C, Jirtle R, Weaver VM, Seewaldt VL
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19258476
p53 Deficiency leads to compensatory up-regulation of p16INK4a.
Leong WF, Chau JF, Li B
Mol Cancer Res. 2009
PubMed ID: 19240179
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation.
Kotake Y, Zeng Y, Xiong Y
Cancer Res. 2009
PubMed ID: 19208841
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
Myocardial Infarction Genetics Consortium, Kathiresan S, Voight BF, Purcell S, Musunuru K, Ardissino D, Mannucci PM, Anand S, Engert JC, Samani NJ, Schunkert H, Erdmann J, Reilly MP, Rader DJ, Morgan T, Spertus JA, Stoll M, Girelli D, McKeown PP, Patterson CC, Siscovick DS, O'Donnell CJ, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Melander O, Altshuler D, Ardissino D, Merlini PA, Berzuini C, Bernardinelli L, Peyvandi F, Tubaro M, Celli P, Ferrario M, Fetiveau R, Marziliano N, Casari G, Galli M, Ribichini F, Rossi M, Bernardi F, Zonzin P, Piazza A, Mannucci PM, Schwartz SM, Siscovick DS, Yee J, Friedlander Y, Elosua R, Marrugat J, Lucas G, Subirana I, Sala J, Ramos R, Kathiresan S, Meigs JB, Williams G, Nathan DM, MacRae CA, O'Donnell CJ, Salomaa V, Havulinna AS, Peltonen L, Melander O, Berglund G, Voight BF, Kathiresan S, Hirschhorn JN, Asselta R, Duga S, Spreafico M, Musunuru K, Daly MJ, Purcell S, Voight BF, Purcell S, Nemesh J, Korn JM, McCarroll SA, Schwartz SM, Yee J, Kathiresan S, Lucas G, Subirana I, Elosua R, Surti A, Guiducci C, Gianniny L, Mirel D, Parkin M, Burtt N, Gabriel SB, Samani NJ, Thompson JR, Braund PS, Wright BJ, Balmforth AJ, Ball SG, Hall AS, Wellcome Trust Case Control Consortium, Schunkert H, Erdmann J, Linsel-Nitschke P, Lieb W, Ziegler A, König I, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Schunkert H, Samani NJ, Erdmann J, Ouwehand W, Hengstenberg C, Deloukas P, Scholz M, Cambien F, Reilly MP, Li M, Chen Z, Wilensky R, Matthai W, Qasim A, Hakonarson HH, Devaney J, Burnett MS, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein SE, Rader DJ, Scheffold T, Berger K, Stoll M, Huge A, Girelli D, Martinelli N, Olivieri O, Corrocher R, Morgan T, Spertus JA, McKeown P, Patterson CC, Schunkert H, Erdmann E, Linsel-Nitschke P, Lieb W, Ziegler A, König IR, Hengstenberg C, Fischer M, Stark K, Grosshennig A, Preuss M, Wichmann HE, Schreiber S, Hólm H, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Engert JC, Do R, Xie C, Anand S, Kathiresan S, Ardissino D, Mannucci PM, Siscovick D, O'Donnell CJ, Samani NJ, Melander O, Elosua R, Peltonen L, Salomaa V, Schwartz SM, Altshuler D
Nat Genet. 2009
PubMed ID: 19198609
P16 immunostaining patterns in microglandular hyperplasia of the cervix and their significance.
Roh MH, Agoston E, Birch C, Crum CP
Int J Gynecol Pathol. 2009
PubMed ID: 19188826
Increased p16 expression in high-grade serous and undifferentiated carcinoma compared with other morphologic types of ovarian carcinoma.
Phillips V, Kelly P, McCluggage WG
Int J Gynecol Pathol. 2009
PubMed ID: 19188815
Increased gamma-tubulin expression and P16INK4A promoter methylation occur together in preinvasive lesions and carcinomas of the breast.
Liu T, Niu Y, Yu Y, Liu Y, Zhang F
Ann Oncol. 2009
PubMed ID: 19131428
Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor).
Stalinska L, Turant M, Tosik D, Sygut J, Kulig A, Kopczynski J, Dziki A, Ferenc T
Histol Histopathol. 2009
PubMed ID: 19130399
A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF.
Bolli N, De Marco MF, Martelli MP, Bigerna B, Pucciarini A, Rossi R, Mannucci R, Manes N, Pettirossi V, Pileri SA, Nicoletti I, Falini B
Leukemia. 2009
PubMed ID: 19005479
Absence of germline epimutation of the CDKN2A gene in familial melanoma.
van Doorn R, Zoutman WH, Gruis NA
J Invest Dermatol. 2009
PubMed ID: 18818678
Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors.
Bastide K, Guilly MN, Bernaudin JF, Joubert C, Lectard B, Levalois C, Malfoy B, Chevillard S
Lung Cancer. 2009
PubMed ID: 18656278
Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19202064
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19196966
8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites.
Zhang HJ, Li WJ, Yang SY, Li SY, Ni JH, Jia HT
J Cell Biochem. 2009
PubMed ID: 19115249
No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Minicucci EM, da Silva GN, Ribeiro DA, Favero Salvadori DM
J Mol Histol. 2009
PubMed ID: 19255859
Increased PDGFRalpha activation disrupts connective tissue development and drives systemic fibrosis.
Olson LE, Soriano P
Dev Cell. 2009
PubMed ID: 19217431
Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.
Schaefer AS, Richter GM, Groessner-Schreiber B, Noack B, Nothnagel M, El Mokhtari NE, Loos BG, Jepsen S, Schreiber S
PLoS Genet. 2009
PubMed ID: 19214202
Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.
van der Net JB, Janssens AC, Defesche JC, Kastelein JJ, Sijbrands EJ, Steyerberg EW
Am J Cardiol. 2009
PubMed ID: 19166692
Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only.
De Schutter H, Geeraerts H, Verbeken E, Nuyts S
Oncol Rep. 2009
PubMed ID: 19148529
Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype.
Akagi T, Ogawa S, Dugas M, Kawamata N, Yamamoto G, Nannya Y, Sanada M, Miller CW, Yung A, Schnittger S, Haferlach T, Haferlach C, Koeffler HP
Haematologica. 2009
PubMed ID: 19144660
Transition of cervical carcinoma in situ to invasive cancer: role of p16 INK4a expression in progression and in recurrence.
Anschau F, Schmitt VM, Lambert AP, Gonçalves MA, Machado DC
Exp Mol Pathol. 2009
PubMed ID: 19100258
Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner.
Zhu Z, Luo Z, Li Y, Ni C, Li H, Zhu M
Hepatology. 2009
PubMed ID: 19085961
Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.
Tabara Y, Osawa H, Kawamoto R, Onuma H, Shimizu I, Miki T, Kohara K, Makino H
Diabetes. 2009
PubMed ID: 19033397
Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.
Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML
Ann Surg Oncol. 2009
PubMed ID: 19020940
Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
Cho YM, Kim TH, Lim S, Choi SH, Shin HD, Lee HK, Park KS, Jang HC
Diabetologia. 2009
PubMed ID: 19002430
Progressive silencing of p14ARF in oesophageal adenocarcinoma.
Huang Y, Peters CJ, Fitzgerald RC, Gjerset RA
J Cell Mol Med. 2009
PubMed ID: 18410530
ARF induces autophagy by virtue of interaction with Bcl-xl.
Pimkina J, Humbey O, Zilfou JT, Jarnik M, Murphy ME
J Biol Chem. 2009
PubMed ID: 19049976
Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: a population-based study.
Dong CX, Deng DJ, Pan KF, Zhang L, Zhang Y, Zhou J, You WC
Int J Cancer. 2009
PubMed ID: 18821580
The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity.
Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, Rodier F, Bernier G
J Neurosci. 2009
PubMed ID: 19144853
Rare Germline Mutations in Cyclin-Dependent Kinase Inhibitor Genes in MEN1 and Related States.
Agarwal SK, Mateo CM, Marx SJ
J Clin Endocrinol Metab. 2009
PubMed ID: 19141585
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T
EMBO J. 2009
PubMed ID: 19057511
[The expression of p16(INK4a) and Ki-67 in atrophic-hyperplastic and dysdysplastic lesions of the vulva]
Gincheva D, Tomov C, Gorchev G, Nikolova M
Akush Ginekol (Sofiia). 2009
PubMed ID: 20198771
Status of p16(INK4a) and E-cadherin gene promoter methylation in Moroccan patients with cervical carcinoma.
Attaleb M, El hamadani W, Khyatti M, Benbacer L, Benchekroun N, Benider A, Amrani M, El Mzibri M
Oncol Res. 2009
PubMed ID: 20112504
Combined detection of p53, p16, Rb, and EGFR mutations in lung cancer by suspension microarray.
Ye Y, Wang D, Su C, Rong T, Guo A
Genet Mol Res. 2009
PubMed ID: 20082263
Increased epithelial stem cell traits in advanced endometrial endometrioid carcinoma.
Chang SJ, Wang TY, Tsai CY, Hu TF, Chang MD, Wang HW
BMC Genomics. 2009
PubMed ID: 20015385
Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients.
Sharma G, Mirza S, Yang YH, Parshad R, Hazrah P, Datta Gupta S, Ralhan R
Cell Oncol. 2009
PubMed ID: 19940364
Wnt4 is not sufficient to induce lobuloalveolar mammary development.
Kim YC, Clark RJ, Pelegri F, Alexander CM
BMC Dev Biol. 2009
PubMed ID: 19878558
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, Qin W, Hou X, Wang C, Bao Y, Xiang K, Jia W
PLoS One. 2009
PubMed ID: 19862325
Aberrant DNA hypermethylation of hMLH-1 and CDKN2A/p16 genes in benign, premalignant and malignant endometrial lesions.
Guida M, Sanguedolce F, Bufo P, Di Spiezio Sardo A, Bifulco G, Nappi C, Pannone G
Eur J Gynaecol Oncol. 2009
PubMed ID: 19697618
Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.
Chen Z, Carracedo A, Lin HK, Koutcher JA, Behrendt N, Egia A, Alimonti A, Carver BS, Gerald W, Teruya-Feldstein J, Loda M, Pandolfi PP
Sci Signal. 2009
PubMed ID: 19690330
Genetic variation in healthy oldest-old.
Halaschek-Wiener J, Amirabbasi-Beik M, Monfared N, Pieczyk M, Sailer C, Kollar A, Thomas R, Agalaridis G, Yamada S, Oliveira L, Collins JA, Meneilly G, Marra MA, Madden KM, Le ND, Connors JM, Brooks-Wilson AR
PLoS One. 2009
PubMed ID: 19680556
Assessment of the effect of betaine on p16 and c-myc DNA methylation and mRNA expression in a chemical induced rat liver cancer model.
Du YP, Peng JS, Sun A, Tang ZH, Ling WH, Zhu HL
BMC Cancer. 2009
PubMed ID: 19642983
[Role of the tumor suppressor ARF in oncogenesis]
Pimkina IuS, Dorosevich AE
Arkh Patol. 2009
PubMed ID: 19514363
Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.
Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M
PLoS One. 2009
PubMed ID: 19462008
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Efeyan A, Murga M, Martinez-Pastor B, Ortega-Molina A, Soria R, Collado M, Fernandez-Capetillo O, Serrano M
PLoS One. 2009
PubMed ID: 19421407
Scoring mechanisms of p16INK4a immunohistochemistry based on either independent nucleic stain or mixed cytoplasmic with nucleic expression can significantly signal to distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray
Koo CL, Kok LF, Lee MY, Wu TS, Cheng YW, Hsu JD, Ruan A, Chao KC, Han CP
J Transl Med. 2009
PubMed ID: 19366452
INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis.
Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, Ibrahim JG, Thomas NE, Sharpless NE
PLoS One. 2009
PubMed ID: 19343170
A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a.
Irelan JT, Gutierrez Del Arroyo A, Gutierrez A, Peters G, Quon KC, Miraglia L, Chanda SK
PLoS One. 2009
PubMed ID: 19340300
Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer.
Goto T, Mizukami H, Shirahata A, Sakata M, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K
Anticancer Res. 2009
PubMed ID: 19331161
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association.
Miyake K, Yang W, Hara K, Yasuda K, Horikawa Y, Osawa H, Furuta H, Ng MC, Hirota Y, Mori H, Ido K, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Wang HY, Tanahashi T, Nakamura N, Takeda J, Maeda E, Yamamoto K, Tokunaga K, Ma RC, So WY, Chan JC, Kamatani N, Makino H, Nanjo K, Kadowaki T, Kasuga M
J Hum Genet. 2009
PubMed ID: 19247372
Epigenetic alteration of p16INK4a gene in dedifferentiation of liposarcoma.
He M, Aisner S, Benevenia J, Patterson F, Harrison LE, Hameed M
Pathol Res Pract. 2009
PubMed ID: 19186005
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
Becker TM, Haferkamp S, Dijkstra MK, Scurr LL, Frausto M, Diefenbach E, Scolyer RA, Reisman DN, Mann GJ, Kefford RF, Rizos H
Mol Cancer. 2009
PubMed ID: 19149898
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.
Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ
Cancer Res. 2009
PubMed ID: 19118015
Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma.
Ohta S, Uemura H, Matsui Y, Ishiguro H, Fujinami K, Kondo K, Miyamoto H, Yazawa T, Danenberg K, Danenberg PV, Tohnai I, Kubota Y
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009
PubMed ID: 19101490
Genetically engineered mouse models of brain cancer and the promise of preclinical testing.
Huse JT, Holland EC
Brain Pathol. 2009
PubMed ID: 19076778
p16 INK4a immunostaining identifies occult CIN lesions in HPV-positive women.
Ordi J, Garcia S, del Pino M, Landolfi S, Alonso I, Quintó L, Torné A
Int J Gynecol Pathol. 2009
PubMed ID: 19047902
Progression of hypermethylation of the p16(INK4A) gene from normal liver to nontumorous liver and hepatocellular carcinoma: an evaluation using quantitative PCR analysis.
Kurita S, Ohkoshi S, Yano M, Yamazaki K, Suzuki K, Aoki YH, Matsuda Y, Wakai T, Shirai Y, Ichida T, Aoyagi Y
Dig Dis Sci. 2009
PubMed ID: 19016326
Common type 2 diabetes risk gene variants associate with gestational diabetes.
Lauenborg J, Grarup N, Damm P, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T
J Clin Endocrinol Metab. 2009
PubMed ID: 18984664
p16INK4a is a beta-catenin target gene and indicates low survival in human colorectal tumors.
Wassermann S, Scheel SK, Hiendlmeyer E, Palmqvist R, Horst D, Hlubek F, Haynl A, Kriegl L, Reu S, Merkel S, Brabletz T, Kirchner T, Jung A
Gastroenterology. 2009
PubMed ID: 18951899
The OGF-OGFr axis utilizes the p16INK4a and p21WAF1/CIP1 pathways to restrict normal cell proliferation.
Cheng F, McLaughlin PJ, Verderame MF, Zagon IS
Mol Biol Cell. 2009
PubMed ID: 18923142
Dermoscopic features of melanomas associated with MC1R variants in Spanish CDKN2A mutation carriers.
Cuéllar F, Puig S, Kolm I, Puig-Butille J, Zaballos P, Martí-Laborda R, Badenas C, Malvehy J
Br J Dermatol. 2009
PubMed ID: 18795926
p16 immunohistochemistry as an alternative marker to distinguish atypical lipomatous tumor from deep-seated lipoma.
He M, Aisner S, Benevenia J, Patterson F, Aviv H, Hameed M
Appl Immunohistochem Mol Morphol. 2009
PubMed ID: 18779733
Characterization of coordinated immediate responses by p16INK4A and p53 pathways in UVB-irradiated human skin cells.
Abd Elmageed ZY, Gaur RL, Williams M, Abdraboh ME, Rao PN, Raj MH, Ismail FM, Ouhtit A
J Invest Dermatol. 2009
PubMed ID: 18719612
A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma.
Hoevenaars BM, van der Avoort IA, de Wilde PC, Massuger LF, Melchers WJ, de Hullu JA, Bulten J
Int J Cancer. 2008
PubMed ID: 18798277
Identification of human papillomavirus in esophageal squamous papillomas.
Bohn OL, Navarro L, Saldivar J, Sanchez-Sosa S
World J Gastroenterol. 2008
PubMed ID: 19084918
MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters.
Höiom V, Tuominen R, Käller M, Lindén D, Ahmadian A, Månsson-Brahme E, Egyhazi S, Sjöberg K, Lundeberg J, Hansson J
Pigment Cell Melanoma Res. 2008
PubMed ID: 19077144
Distinct thresholds govern Myc's biological output in vivo.
Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, Bui DA, Brown-Swigart L, Johnson L, Evan GI
Cancer Cell. 2008
PubMed ID: 19061836
Intrinsically unstructured domains of Arf and Hdm2 form bimolecular oligomeric structures in vitro and in vivo.
Sivakolundu SG, Nourse A, Moshiach S, Bothner B, Ashley C, Satumba J, Lahti J, Kriwacki RW
J Mol Biol. 2008
PubMed ID: 18809412
Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF.
Hemmati PG, Normand G, Gillissen B, Wendt J, Dörken B, Daniel PT
Oncogene. 2008
PubMed ID: 18806827
Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands.
Vékony H, Röser K, Löning T, Raaphorst FM, Leemans CR, Van der Waal I, Bloemena E
Histopathology. 2008
PubMed ID: 19076682
Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteins.
Iwasa A, Oda Y, Kurihara S, Ohishi Y, Yasunaga M, Nishimura I, Takagi E, Kobayashi H, Wake N, Tsuneyoshi M
Pathol Int. 2008
PubMed ID: 19067849
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Genomic rearrangements of the CDKN2A locus are infrequent in Italian malignant melanoma families without evidence of CDKN2A/CDK4 point mutations.
Vignoli M, Scaini MC, Ghiorzo P, Sestini R, Bruno W, Menin C, Gensini F, Piazzini M, Testori A, Manoukian S, Orlando C, D'Andrea E, Bianchi-Scarrà G, Genuardi M
Melanoma Res. 2008
PubMed ID: 19011513
Susceptibility loci for intracranial aneurysm in European and Japanese populations.
Bilguvar K, Yasuno K, Niemelä M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, van den Berg LH, Mane S, Mason CE, Choi M, Gaál E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MM, Wijmenga C, State MW, Rinkel GJ, Hernesniemi J, Jääskeläinen JE, Palotie A, Inoue I, Lifton RP, Günel M
Nat Genet. 2008
PubMed ID: 18997786
CDKN2A mutations and MC1R variants in Italian patients with single or multiple primary melanoma.
Pastorino L, Bonelli L, Ghiorzo P, Queirolo P, Battistuzzi L, Balleari E, Nasti S, Gargiulo S, Gliori S, Savoia P, Abate Osella S, Bernengo MG, Bianchi Scarrà G
Pigment Cell Melanoma Res. 2008
PubMed ID: 18983535
Prognostic significance of p16/cdkn2a loss in pleural malignant mesotheliomas.
Dacic S, Kothmaier H, Land S, Shuai Y, Halbwedl I, Morbini P, Murer B, Comin C, Galateau-Salle F, Demirag F, Zeren H, Attanoos R, Gibbs A, Cagle P, Popper H
Virchows Arch. 2008
PubMed ID: 18958493
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Maggi LB, Kuchenruether M, Dadey DY, Schwope RM, Grisendi S, Townsend RR, Pandolfi PP, Weber JD
Mol Cell Biol. 2008
PubMed ID: 18809582
Genotype score in addition to common risk factors for prediction of type 2 diabetes.
Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PW, D'Agostino RB, Cupples LA
N Engl J Med. 2008
PubMed ID: 19020323
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
Signer RA, Montecino-Rodriguez E, Witte ON, Dorshkind K
Genes Dev. 2008
PubMed ID: 19056891
The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene.
Wang PY, Young F, Chen CY, Stevens BM, Neering SJ, Rossi RM, Bushnell T, Kuzin I, Heinrich D, Bottaro A, Jordan CT
Blood. 2008
PubMed ID: 18755985
Telomerase reverse transcriptase delays aging in cancer-resistant mice.
Tomás-Loba A, Flores I, Fernández-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borrás C, Matheu A, Klatt P, Flores JM, Viña J, Serrano M, Blasco MA
Cell. 2008
PubMed ID: 19013273
The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
Gizard F, Nomiyama T, Zhao Y, Findeisen HM, Heywood EB, Jones KL, Staels B, Bruemmer D
Circ Res. 2008
PubMed ID: 18818403
[Expression of epidermal growth factor receptor Ki67 and p16 in human middle ear cholesteatoma].
Li S, Zhan H, Peng S
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19157151
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
Nemtsova MN, Pal'tseva EM, Babaian AIu, Mikhaĭlenko DS, Babenko OV, Samofalova OIu, Tsar'kov PV, Zaletaev DV
Mol Biol (Mosk). 2008
PubMed ID: 19140325
Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia.
Kresty LA, Mallery SR, Knobloch TJ, Li J, Lloyd M, Casto BC, Weghorst CM
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18990760
Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families.
de Snoo FA, Bishop DT, Bergman W, van Leeuwen I, van der Drift C, van Nieuwpoort FA, Out-Luiting CJ, Vasen HF, ter Huurne JA, Frants RR, Willemze R, Breuning MH, Gruis NA
Clin Cancer Res. 2008
PubMed ID: 18981015
p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors.
Gallagher SJ, Thompson JF, Indsto J, Scurr LL, Lett M, Gao BF, Dunleavey R, Mann GJ, Kefford RF, Rizos H
Neoplasia. 2008
PubMed ID: 18953432
Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer.
Suga Y, Miyajima K, Oikawa T, Maeda J, Usuda J, Kajiwara N, Ohira T, Uchida O, Tsuboi M, Hirano T, Kato H, Ikeda N
Oncol Rep. 2008
PubMed ID: 18949413
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.
Kuo ML, den Besten W, Thomas MC, Sherr CJ
Cell Cycle. 2008
PubMed ID: 18948745
Bmi1 promotes prostate tumorigenesis via inhibiting p16(INK4A) and p14(ARF) expression.
Fan C, He L, Kapoor A, Gillis A, Rybak AP, Cutz JC, Tang D
Biochim Biophys Acta. 2008
PubMed ID: 18817867
P16 alterations increase the metastatic potential of endometrial carcinoma.
Ignatov A, Bischoff J, Schwarzenau C, Krebs T, Kuester D, Herrmann K, Costa SD, Roessner A, Semczuk A, Schneider-Stock R
Gynecol Oncol. 2008
PubMed ID: 18790522
p16 ink4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri.
Negri G, Bellisano G, Zannoni GF, Rivasi F, Kasal A, Vittadello F, Antoniazzi S, Faa G, Ambu R, Egarter-Vigl E
Am J Surg Pathol. 2008
PubMed ID: 18769337
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
van Hoek M, Dehghan A, Witteman JC, van Duijn CM, Uitterlinden AG, Oostra BA, Hofman A, Sijbrands EJ, Janssens AC
Diabetes. 2008
PubMed ID: 18694974
Methylation-related silencing of p14ARF gene correlates with telomerase activity and mRNA expression of human telomerase reverse transcriptase in hepatocellular carcinoma.
Zhang C, Guo X, Zhang L, Lu Z, Ma N, Cheng Y, Shen F, Zhang B, Wu M, Wei L
J Surg Oncol. 2008
PubMed ID: 18683194
C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf).
Ewing SJ, Zhu S, Zhu F, House JS, Smart RC
Cell Death Differ. 2008
PubMed ID: 18636078
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.
Nishino J, Kim I, Chada K, Morrison SJ
Cell. 2008
PubMed ID: 18957199
Two wobble-splicing events affect ING4 protein subnuclear localization and degradation.
Tsai KW, Tseng HC, Lin WC
Exp Cell Res. 2008
PubMed ID: 18775696
Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells.
Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, Tang DG
J Biol Chem. 2008
PubMed ID: 18662989
Expression of p14ARF, MDM2, and MDM4 in human retinoblastoma.
Guo Y, Pajovic S, Gallie BL
Biochem Biophys Res Commun. 2008
PubMed ID: 18644346
A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukaemia reveals genomic deletion, copy number neutral loss of heterozygosity and association with specific cytogenetic subgroups.
Sulong S, Moorman AV, Irving JA, Strefford JC, Konn ZJ, Case MC, Minto L, Barber KE, Parker H, Wright SL, Stewart AR, Bailey S, Bown NP, Hall AG, Harrison CJ
Blood. 2008
PubMed ID: 18838613
Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma.
Adams L, Roth MJ, Abnet CC, Dawsey SP, Qiao YL, Wang GQ, Wei WQ, Lu N, Dawsey SM, Woodson K
Cancer Prev Res (Phila Pa). 2008
PubMed ID: 19137073
[Demethylation and transcription of p16 gene in malignant lymphoma cell line CA46 induced by EGCG].
Yu AF, Shen JZ, Chen ZZ, Fan LP, Lin FA
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 18928598
[Phenylhexyl isothiocyanate reducing U266 cell line methylation level of p16 gene].
Chen BA, Shou BM, Zhou DR, Ding JH, Gao C, Sun YY, Wang J, Chen J, Zhao G, Song HH, Bao W, Liu DL, Ma XD, Lu ZH
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008
PubMed ID: 18928595
p16(INK4a)-induced senescence is disabled by melanoma-associated mutations.
Haferkamp S, Becker TM, Scurr LL, Kefford RF, Rizos H
Aging Cell. 2008
PubMed ID: 18843795
Methylation of the MGMT and p16 genes in sporadic colorectal carcinoma and corresponding normal colonic mucosa.
Krakowczyk L, Strzelczyk JK, Adamek B, Zalewska-Ziob M, Arendt J, Półtorak S, Maciejewski B, Wiczkowski A
Med Sci Monit. 2008
PubMed ID: 18830187
p16 expression differentiates high-risk gastrointestinal stromal tumor and predicts poor outcome.
Schmieder M, Wolf S, Danner B, Stoehr S, Juchems MS, Wuerl P, Henne-Bruns D, Knippschild U, Hasel C, Kramer K
Neoplasia. 2008
PubMed ID: 18813351
Alterations in the p16INK4a/cyclin D1/RB pathway in gastrointestinal tract endocrine tumors.
Li AF, Li AC, Tsay SH, Li WY, Liang WY, Chen JY
Am J Clin Pathol. 2008
PubMed ID: 18794045
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
p16 gene expression in basal cell carcinoma.
Eshkoor SA, Ismail P, Rahman SA, Oshkour SA
Arch Med Res. 2008
PubMed ID: 18760195
p16 expression in colorectal adenocarcinoma: marker of aggressiveness and morphological types.
Lam AK, Ong K, Giv MJ, Giv MJ, Ho YH
Pathology. 2008
PubMed ID: 18752124
Nucleolar p19ARF, unlike mitochondrial smARF, is incapable of inducing p53-independent autophagy.
Reef S, Kimchi A
Autophagy. 2008
PubMed ID: 18719357
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
Debniak T, van de Wetering T, Scott R, Nagay L, Cybulski C, Górski B, Jakubowska A, Gronwald J, Masojć B, Huzarski T, Byrski T, Nej-Wołosiak K, Kładny J, Maleszka R, Lubinski J
Eur J Cancer Prev. 2008
PubMed ID: 18714178
Interaction of p14ARF with Brca1 in cancer cell lines and primary breast cancer.
He L, Fan C, Ning X, Feng X, Liu Y, Chen B, Tang D
Cell Biol Int. 2008
PubMed ID: 18703154
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
p16, cyclin D1, Ki-67, and AMACR as markers for dysplasia in Barrett esophagus.
Shi XY, Bhagwandeen B, Leong AS
Appl Immunohistochem Mol Morphol. 2008
PubMed ID: 18665038
YY1 restrained cell senescence through repressing the transcription of p16.
Wang X, Feng Y, Xu L, Chen Y, Zhang Y, Su D, Ren G, Lu J, Huang B
Biochim Biophys Acta. 2008
PubMed ID: 18558095
Frequent p16 inactivation by homozygous deletion or methylation is associated with a poor prognosis in Japanese patients with pleural mesothelioma.
Kobayashi N, Toyooka S, Yanai H, Soh J, Fujimoto N, Yamamoto H, Ichihara S, Kimura K, Ichimura K, Sano Y, Kishimoto T, Date H
Lung Cancer. 2008
PubMed ID: 18395929
p16INK4a downregulation is involved in immortalization of primary human prostate epithelial cells induced by telomerase.
Shao G, Balajee AS, Hei TK, Zhao Y
Mol Carcinog. 2008
PubMed ID: 18383581
The yin and yang of the Cdkn2a locus in senescence and aging.
Baker DJ, Jin F, van Deursen JM
Cell Cycle. 2008
PubMed ID: 18769141
Correlation analysis between the expression of P21WAF1/CIP1, P16 proteins and human glioma.
Song T, Wu J, Fang F, Chen F, Huo L, Zhang M, Wu L, Zhai Z, Yang L, Fang J
Clin Exp Med. 2008
PubMed ID: 18791688
Promoter hypermethylation of the p16 gene is associated with poor prognosis in recurrent early-stage hepatocellular carcinoma.
Ko E, Kim Y, Kim SJ, Joh JW, Song S, Park CK, Park J, Kim DH
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18723830
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.
Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW
Diabetologia. 2008
PubMed ID: 18618095
Is p16(INK4a) protein expression in oral ST lesions a reliable precancerous marker?
Greer RO, Meyers A, Said SM, Shroyer KR
Int J Oral Maxillofac Surg. 2008
PubMed ID: 18606525
Changes in p19Arf localization accompany apoptotic crisis during pre-B-cell transformation by Abelson murine leukemia virus.
Zimmerman RS, Rosenberg N
J Virol. 2008
PubMed ID: 18579612
The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma.
Mascaux C, Bex F, Martin B, Burny A, Haller A, Paesmans M, Willard-Gallo K, Ninane V, Sculier JP
Eur Respir J. 2008
PubMed ID: 18480108
Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families.
de Snoo FA, Hottenga JJ, Gillanders EM, Sandkuijl LA, Jones MP, Bergman W, van der Drift C, van Leeuwen I, van Mourik L, Huurne JA, Frants RR, Willemze R, Breuning MH, Trent JM, Gruis NA
Eur J Hum Genet. 2008
PubMed ID: 18398432
High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka.
Takeshima M, Saitoh M, Kusano K, Nagayasu H, Kurashige Y, Malsantha M, Arakawa T, Takuma T, Chiba I, Kaku T, Shibata T, Abiko Y
J Oral Pathol Med. 2008
PubMed ID: 18284544
Expression of p16 and cervical infection with high-risk human papillomavirus are not related to p53 activity in cervical intraepithelial neoplasia.
Bragança JF, Sarian LO, Pitta DR, Maito AB, Vassallo J, Pignataro F, Andrade LA, Derchain S
Int J Gynecol Cancer. 2008
PubMed ID: 18021213
Linkage and Association Study of Late-Onset Alzheimer Disease Families Linked to 9p21.3.
Züchner S, Gilbert JR, Martin ER, Leon-Guerrero CR, Xu PT, Browning C, Bronson PG, Whitehead P, Schmechel DE, Haines JL, Pericak-Vance MA
Ann Hum Genet. 2008
PubMed ID: 18761660
Senescence of activated stellate cells limits liver fibrosis.
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW
Cell. 2008
PubMed ID: 18724938
Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Dovey JS, Zacharek SJ, Kim CF, Lees JA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18697930
Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity.
Farmer TE, Williams CS, Washington MK, Hiebert SW
J Cell Biochem. 2008
PubMed ID: 18442038
Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide.
Shi MD, Lin HH, Lee YC, Chao JK, Lin RA, Chen JH
Chem Biol Interact. 2008
PubMed ID: 18619950
[Epstein-Barr virus infection and p16(INK4a) overexpression in gastric adenocarcinoma]
Wang P, Zhang Q, Yang JF, Cheng ZN, Zhang K, Yu DH
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2008
PubMed ID: 19105332
p16 Promoter methylation is a potential predictor of malignant transformation in oral epithelial dysplasia.
Hall GL, Shaw RJ, Field EA, Rogers SN, Sutton DN, Woolgar JA, Lowe D, Liloglou T, Field JK, Risk JM
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18708411
COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells.
Mroz EA, Baird AH, Michaud WA, Rocco JW
Cancer Res. 2008
PubMed ID: 18676825
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling.
Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H
Genes Dev. 2008
PubMed ID: 18676808
Genetic testing in familial melanoma: uptake and implications.
de Snoo FA, Riedijk SR, van Mil AM, Bergman W, ter Huurne JA, Timman R, Bertina W, Gruis NA, Vasen HF, van Haeringen A, Breuning MH, Tibben A
Psychooncology. 2008
PubMed ID: 18613292
Increased melanocytic nevi and nevus density in a G-34T CDKN2A/p16 melanoma-prone pedigree.
Florell SR, Meyer LJ, Boucher KM, Grossman D, Cannon-Albright LA, Harris RM, Samlowski WE, Zone JJ, Leachman SA
J Invest Dermatol. 2008
PubMed ID: 18337833
CDKN2A deletions in acute lymphoblastic leukemia of adolescents and young adults: an array CGH study.
Usvasalo A, Savola S, Räty R, Vettenranta K, Harila-Saari A, Koistinen P, Savolainen ER, Elonen E, Saarinen-Pihkala UM, Knuutila S
Leuk Res. 2008
PubMed ID: 18328560
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium.
Pietersen AM, Evers B, Prasad AA, Tanger E, Cornelissen-Steijger P, Jonkers J, van Lohuizen M
Curr Biol. 2008
PubMed ID: 18635350
The contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanoma.
Lesueur F, de Lichy M, Barrois M, Durand G, Bombled J, Avril MF, Chompret A, Boitier F, Lenoir GM, French Familial Melanoma Study Group, Bressac-de Paillerets B, Baccard M, Bachollet B, Berthet P, Bonadona V, Bonnetblanc JM, Caron O, Chevrant-Breton J, Cuny JF, Dalle S, Delaunay M, Demange L, De Quatrebarbes J, Doré JF, Frénay M, Fricker JP, Gauthier-Villars M, Gesta P, Giraud S, Gorry P, Grange F, Green A, Huiart L, Janin N, Joly P, Kérob D, Lasset C, Leroux D, Limacher JM, Longy M, Mansard S, Marrou K, Martin-Denavit T, Mateus C, Maubec E, Olivier-Faivre L, Orlandini V, Pujol P, Sassolas B, Stoppa-Lyonnet D, Thomas L, Vabres P, Venat L, Wierzbicka E, Zattara H
Br J Cancer. 2008
PubMed ID: 18612309
Aurora A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.
Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M, Saya H
Oncogene. 2008
PubMed ID: 18372918
Analysis of gene rearrangements using a fluorescence in situ hybridization method in Mexican patients with acute lymphoblastic leukemia: experience at a single institution.
Pérez-Vera P, Salas C, Montero-Ruiz O, Frías S, Dehesa G, Jarquín B, Rivera-Luna R
Cancer Genet Cytogenet. 2008
PubMed ID: 18617057
Consortium analysis of 7 candidate SNPs for ovarian cancer.
Ramus SJ, Vierkant RA, Johnatty SE, Pike MC, Van Den Berg DJ, Wu AH, Pearce CL, Menon U, Gentry-Maharaj A, Gayther SA, Dicioccio RA, McGuire V, Whittemore AS, Song H, Easton DF, Pharoah PD, Garcia-Closas M, Chanock S, Lissowska J, Brinton L, Terry KL, Cramer DW, Tworoger SS, Hankinson SE, Berchuck A, Moorman PG, Schildkraut JM, Cunningham JM, Liebow M, Kjaer SK, Hogdall E, Hogdall C, Blaakaer J, Ness RB, Moysich KB, Edwards RP, Carney ME, Lurie G, Goodman MT, Wang-Gohrke S, Kropp S, Chang-Claude J, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer), Webb PM, Chen X, Beesley J, Chenevix-Trench G, Goode EL, Ovarian Cancer Association Consortium
Int J Cancer. 2008
PubMed ID: 18431743
Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.
Stracker TH, Couto SS, Cordon-Cardo C, Matos T, Petrini JH
Mol Cell. 2008
PubMed ID: 18614044
Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16.
Aghi M, Visted T, Depinho RA, Chiocca EA
Oncogene. 2008
PubMed ID: 18345032
Inducible re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasis.
Schulz P, Scholz A, Rexin A, Hauff P, Schirner M, Wiedenmann B, Detjen K
Br J Cancer. 2008
PubMed ID: 18577984
Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
van der Net JB, Oosterveer DM, Versmissen J, Defesche JC, Yazdanpanah M, Aouizerat BE, Steyerberg EW, Malloy MJ, Pullinger CR, Kastelein JJ, Kane JP, Sijbrands EJ
Eur Heart J. 2008
PubMed ID: 18599554
Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 Genes Confer Risk of Type 2 Diabetes Independently of BMI in the German KORA Studies.
Herder C, Rathmann W, Strassburger K, Finner H, Grallert H, Huth C, Meisinger C, Gieger C, Martin S, Giani G, Scherbaum WA, Wichmann HE, Illig T
Horm Metab Res. 2008
PubMed ID: 18597214
[Expression of MIF, VEGF and p16 proteins and their correlation with clinicopathological features in cervical cancer]
Li W, He M, Zeng JF, Xia JT, Chen LZ, Chen Y, Liu JX
Zhonghua Zhong Liu Za Zhi. 2008
PubMed ID: 19062717
[Correlation of p16/INK4a gene damages and protein expression in the tumor tissue of sporadic breast cancer]
Nemtsova MV, Zemliakova VV, Kuznetsova EV, Popova OP, Zavalishina LE, Frank GA, Zaletaev DV
Arkh Patol. 2008
PubMed ID: 18807517
p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA.
Godoy AE, Mandelli J, Oliveira FH, Calegari S, Moura LB, Serafini EP
Braz J Med Biol Res. 2008
PubMed ID: 18719739
Tumor suppression by p53 in the absence of Atm.
Bailey SL, Gurley KE, Hoon-Kim K, Kelly-Spratt KS, Kemp CJ
Mol Cancer Res. 2008
PubMed ID: 18583527
Rearrangement and allelic imbalance on chromosome 5 leads to homozygous deletions in the CDKN2A/2B tumor suppressor gene region in rat endometrial cancer.
Adamovic T, Hamta A, Roshani L, Lü X, Röhme D, Helou K, Klinga-Levan K, Levan G
Cancer Genet Cytogenet. 2008
PubMed ID: 18558284
PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts.
Gan Q, Huang J, Zhou R, Niu J, Zhu X, Wang J, Zhang Z, Tong T
J Cell Sci. 2008
PubMed ID: 18544633
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency.
Baker DJ, Perez-Terzic C, Jin F, Pitel K, Niederländer NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM
Nat Cell Biol. 2008
PubMed ID: 18516091
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A
Hypertension. 2008
PubMed ID: 18504326
Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas.
Kishimoto I, Mitomi H, Ohkura Y, Kanazawa H, Fukui N, Watanabe M
J Surg Oncol. 2008
PubMed ID: 18484097
p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer.
Wettergren Y, Odin E, Nilsson S, Carlsson G, Gustavsson B
Mol Med. 2008
PubMed ID: 18418463
Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer.
Sirera R, Gil M, Blasco A, Cabrera A, Safont MJ, Iranzo V, Cayuela D, Rosell R, Camps C
Lung Cancer. 2008
PubMed ID: 18243403
p14ARF hypermethylation is common but INK4a-ARF locus or p53 mutations are rare in Merkel cell carcinoma.
Lassacher A, Heitzer E, Kerl H, Wolf P
J Invest Dermatol. 2008
PubMed ID: 18219279
Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia.
Ko RM, Kim HG, Wolff L, Klug CA
Leuk Res. 2008
PubMed ID: 18037485
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.
Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN
J Cell Biol. 2008
PubMed ID: 18591425
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
Lango H, The UK Type 2 Diabetes Genetics Consortium, Palmer CN, Morris AD, Zeggini E, Hattersley AT, McCarthy MI, Frayling TM, Weedon MN
Diabetes. 2008
PubMed ID: 18591388
Cdc6 determines utilization of p21(WAF1/CIP1)-dependent damage checkpoint in S phase cells.
Kan Q, Jinno S, Kobayashi K, Yamamoto H, Okayama H
J Biol Chem. 2008
PubMed ID: 18458079
[The correlative analysis of indefinite dysplasia and dysplasia, and its p16 methylation in human gastric mucosa with Helicobacter pylori infection]
Dong CX, Deng da J, Zhou J, Zhang L, Ma JL, Pan KF, You WC
Beijing Da Xue Xue Bao. 2008
PubMed ID: 18560456
p14ARF interacts with DAXX: effects on HDM2 and p53.
Ivanchuk SM, Mondal S, Rutka JT
Cell Cycle. 2008
PubMed ID: 18583933
Association of p16 homozygous deletions with clinicopathologic characteristics and EGFR/KRAS/p53 mutations in lung adenocarcinoma.
Iwakawa R, Kohno T, Anami Y, Noguchi M, Suzuki K, Matsuno Y, Mishima K, Nishikawa R, Tashiro F, Yokota J
Clin Cancer Res. 2008
PubMed ID: 18559592
Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma.
Blons H, Pallier K, Le Corre D, Danel C, Tremblay M, Houdayer C, Fabre-Guillevin E, Riquet M, Dessen P, Laurent-Puig P
BMC Med Genomics. 2008
PubMed ID: 18549475
A mouse to human search for plasma proteome changes associated with pancreatic tumor development.
Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM
PLoS Med. 2008
PubMed ID: 18547137
Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis.
Kanellou P, Zaravinos A, Zioga M, Stratigos A, Baritaki S, Soufla G, Zoras O, Spandidos DA
Cancer Lett. 2008
PubMed ID: 18331779
Simultaneous knockdown of BRAF and expression of INK4A in melanoma cells leads to potent growth inhibition and apoptosis.
Zhao Y, Zhang Y, Yang Z, Li A, Dong J
Biochem Biophys Res Commun. 2008
PubMed ID: 18402768
Frequent p16-independent inactivation of p14ARF in human melanoma.
Freedberg DE, Rigas SH, Russak J, Gai W, Kaplow M, Osman I, Turner F, Randerson-Moor JA, Houghton A, Busam K, Timothy Bishop D, Bastian BC, Newton-Bishop JA, Polsky D
J Natl Cancer Inst. 2008
PubMed ID: 18505964
Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer.
Lima EM, Leal MF, Burbano RR, Khayat AS, Assumpção PP, Bello MJ, Rey JA, Smith MA, Casartelli C
Braz J Med Biol Res. 2008
PubMed ID: 18622497
Generation and characterization of monoclonal antibodies to NIAM: a nuclear interactor of ARF and Mdm2.
Hagen J, Tompkins V, Dudakovic A, Weydert JA, Quelle DE
Hybridoma (Larchmt). 2008
PubMed ID: 18582208
CDKN2A/p16 genetic test reporting improves early detection intentions and practices in high-risk melanoma families.
Aspinwall LG, Leaf SL, Dola ER, Kohlmann W, Leachman SA
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18559569
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.
Itahana K, Zhang Y
Cancer Cell. 2008
PubMed ID: 18538737
Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer.
Lee JY, Jang KS, Shin DH, Oh MY, Kim HJ, Kim Y, Kong G
Cancer Res. 2008
PubMed ID: 18519679
Methylation of the p16INK4A promoter is associated with malignant behavior in abdominal extra-adrenal paragangliomas but not pheochromocytomas.
Kiss NB, Geli J, Lundberg F, Avci C, Velazquez-Fernandez D, Hashemi J, Weber G, Höög A, Ekström TJ, Bäckdahl M, Larsson C
Endocr Relat Cancer. 2008
PubMed ID: 18509008
Genome-wide association study of susceptibility alleles for coronary artery disease.
Marian AJ
Curr Atheroscler Rep. 2008
PubMed ID: 18489844
Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder.
Lynch BC, Lathrop SL, Ye D, Ma TY, Cerilli LA
Ann Diagn Pathol. 2008
PubMed ID: 18486890
A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL).
Harland M, Goldstein AM, Kukalizch K, Taylor C, Hogg D, Puig S, Badenas C, Gruis N, ter Huurne J, Bergman W, Hayward NK, Stark M, Tsao H, Tucker MA, Landi MT, Scarra GB, Ghiorzo P, Kanetsky PA, Elder D, Mann GJ, Holland EA, Bishop DT, Bishop JN, GenoMEL, the Melanoma Genetics Consortium
Eur J Cancer. 2008
PubMed ID: 18394881
Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas.
Chiosea S, Krasinskas A, Cagle PT, Mitchell KA, Zander DS, Dacic S
Mod Pathol. 2008
PubMed ID: 18327208
Type 2 diabetes susceptibility loci in the Ashkenazi Jewish population.
Bronstein M, Pisanté A, Yakir B, Darvasi A
Hum Genet. 2008
PubMed ID: 18516622
Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.
Azzato EM, Driver KE, Lesueur F, Shah M, Greenberg D, Easton DF, Teschendorff AE, Caldas C, Caporaso NE, Pharoah PD
Breast Cancer Res. 2008
PubMed ID: 18507837
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.
Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard TJ, Rogers J, Jonkers J, Wessels L, Adams DJ, van Lohuizen M, Berns A
Cell. 2008
PubMed ID: 18485879
The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.
Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA, Van Pelt CS, Lozano G
Genes Dev. 2008
PubMed ID: 18483220
Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes.
Magnusson S, Borg A, Kristoffersson U, Nilbert M, Wiebe T, Olsson H
Fam Cancer. 2008
PubMed ID: 18481196
p14ARF is capable of promoting HIV-1 tat degradation.
Gargano B, Fiorillo M, Amente S, Majello B, Lania L
Cell Cycle. 2008
PubMed ID: 18418067
p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis.
Ruddell A, Kelly-Spratt KS, Furuya M, Parghi SS, Kemp CJ
Oncogene. 2008
PubMed ID: 18059331
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.
Yamashita M, Kuwahara M, Suzuki A, Hirahara K, Shinnaksu R, Hosokawa H, Hasegawa A, Motohashi S, Iwama A, Nakayama T
J Exp Med. 2008
PubMed ID: 18411339
Large-scale analysis of the genetic and epigenetic alterations in hepatocellular carcinoma from Southeast China.
Su H, Zhao J, Xiong Y, Xu T, Zhou F, Yuan Y, Zhang Y, Zhuang SM
Mutat Res. 2008
PubMed ID: 18358501
Implication of Genetic Variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2 and FTO in Type 2 Diabetes and Obesity in 6719 Asians.
Ng MC, Park KS, Oh B, Tam CH, Cho YM, Shin HD, Lam VK, Ma RC, So WY, Cho YS, Kim HL, Lee HK, Chan JC, Cho NH
Diabetes. 2008
PubMed ID: 18469204
Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors.
Akala OO, Park IK, Qian D, Pihalja M, Becker MW, Clarke MF
Nature. 2008
PubMed ID: 18418377
Association between polymorphisms in cell cycle genes and advanced prostate carcinoma.
Kibel AS, Jin CH, Klim A, Luly J, A Roehl K, Wu WS, Suarez BK
Prostate. 2008
PubMed ID: 18459109
DNA methylation-independent regulation of p16 in epithelial cells during mouse mammary gland development.
Tsellou E, Michailidi C, Pafiti A, Troungos C
Epigenetics. 2008
PubMed ID: 18567945
Constitutive activation of Raf-1 induces glioma formation in mice.
Lyustikman Y, Momota H, Pao W, Holland EC
Neoplasia. 2008
PubMed ID: 18472967
Inactivation of p16 by CpG hypermethylation in renal cell carcinoma.
Vidaurreta M, Maestro ML, Sanz-Casla MT, Maestro C, Rafael S, Veganzones S, Moreno J, Blanco J, Silmi A, Arroyo M
Urol Oncol. 2008
PubMed ID: 18452812
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR, Almgren P, Andersen G, Ardlie K, Boström KB, Bergman RN, Bonnycastle LL, Borch-Johnsen K, Burtt NP, Chen H, Chines PS, Daly MJ, Deodhar P, Ding CJ, Doney AS, Duren WL, Elliott KS, Erdos MR, Frayling TM, Freathy RM, Gianniny L, Grallert H, Grarup N, Groves CJ, Guiducci C, Hansen T, Herder C, Hitman GA, Hughes TE, Isomaa B, Jackson AU, Jørgensen T, Kong A, Kubalanza K, Kuruvilla FG, Kuusisto J, Langenberg C, Lango H, Lauritzen T, Li Y, Lindgren CM, Lyssenko V, Marvelle AF, Meisinger C, Midthjell K, Mohlke KL, Morken MA, Morris AD, Narisu N, Nilsson P, Owen KR, Palmer CN, Payne F, Perry JR, Pettersen E, Platou C, Prokopenko I, Qi L, Qin L, Rayner NW, Rees M, Roix JJ, Sandbaek A, Shields B, Sjögren M, Steinthorsdottir V, Stringham HM, Swift AJ, Thorleifsson G, Thorsteinsdottir U, Timpson NJ, Tuomi T, Tuomilehto J, Walker M, Watanabe RM, Weedon MN, Willer CJ, Wellcome Trust Case Control Consortium, Illig T, Hveem K, Hu FB, Laakso M, Stefansson K, Pedersen O, Wareham NJ, Barroso I, Hattersley AT, Collins FS, Groop L, McCarthy MI, Boehnke M, Altshuler D
Nat Genet. 2008
PubMed ID: 18372903
Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids.
Duesing K, Fatemifar G, Charpentier G, Marre M, Tichet J, Hercberg S, Balkau B, Froguel P, Gibson F
Diabetologia. 2008
PubMed ID: 18368387
E2f6 and Bmi1 cooperate in axial skeletal development.
Courel M, Friesenhahn L, Lees JA
Dev Dyn. 2008
PubMed ID: 18366140
Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.
Suzuki A, Sekiya S, Büscher D, Izpisúa Belmonte JC, Taniguchi H
Development. 2008
PubMed ID: 18356246
Whole genome analyses suggest ischemic stroke and heart disease share an association with polymorphisms on chromosome 9p21.
Matarin M, Brown WM, Singleton A, Hardy JA, Meschia JF, ISGS investigators
Stroke. 2008
PubMed ID: 18340101
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.
Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP
Mol Cell Biol. 2008
PubMed ID: 18332116
Anal intraepithelial neoplasia: correlation of grade with p16INK4a immunohistochemistry and HPV in situ hybridization.
Bernard JE, Butler MO, Sandweiss L, Weidner N
Appl Immunohistochem Mol Morphol. 2008
PubMed ID: 18301250
Decreased expression of p16 in ovarian cancers represents an unfavourable prognostic factor.
Surowiak P, Materna V, Maciejczyk A, Pudelko M, Suchocki S, Kedzia W, Nowak-Markwitz E, Dumanska M, Spaczynski M, Zabel M, Dietel M, Lage H
Histol Histopathol. 2008
PubMed ID: 18283637
CDKN2A mutations and melanoma risk in the Icelandic population.
Goldstein AM, Stacey SN, Olafsson JH, Jonsson GF, Helgason A, Sulem P, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Kjartansson J, Kostic J, Masson G, Kristjansson K, Gulcher JR, Kong A, Thorsteinsdottir U, Rafnar T, Tucker MA, Stefansson K
J Med Genet. 2008
PubMed ID: 18178632
Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation.
Shirako E, Hirayama N, Tsukada Y, Tanaka T, Kitamura N
J Cell Biochem. 2008
PubMed ID: 18004740
Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression.
Bahta AW, Farjo N, Farjo B, Philpott MP
J Invest Dermatol. 2008
PubMed ID: 17989730
Small mitochondrial ARF (smARF) is located in both the nucleus and cytoplasm, induces cell death, and activates p53 in mouse fibroblasts.
Ueda Y, Koya T, Yoneda-Kato N, Kato JY
FEBS Lett. 2008
PubMed ID: 18381074
Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1.
Huang Y, Wu M, Li HY
J Biol Chem. 2008
PubMed ID: 18305112
Immunochemical analysis of HPV L1 capsid protein and p16 protein in liquid-based cytology samples from uterine cervical lesions.
Yoshida T, Sano T, Kanuma T, Owada N, Sakurai S, Fukuda T, Nakajima T
Cancer. 2008
PubMed ID: 18300235
Association analysis of the type 2 diabetes loci in type 1 diabetes.
Qu HQ, Grant SF, Bradfield JP, Kim C, Frackelton E, Hakonarson H, Polychronakos C
Diabetes. 2008
PubMed ID: 18426861
Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology.
Lubiński J, Korzeń M, Górski B, Cybulski C, Dębniak T, Jakubowska A, Jaworska K, Wokołorczyk D, Mędrek K, Matyjasik J, Huzarski T, Byrski T, Gronwald J, Masojć B, Lener M, Szymańska A, Szymańska-Pasternak J, Serrano-Fernàndez P, Piegat A, Uciński R, Domagała P, Domagała W, Chosia M, Kładny J, Górecka B, Narod S, Scott R
Breast Cancer Res Treat. 2008
PubMed ID: 18415014
Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification.
Majid S, Kikuno N, Nelles J, Noonan E, Tanaka Y, Kawamoto K, Hirata H, Li LC, Zhao H, Okino ST, Place RF, Pookot D, Dahiya R
Cancer Res. 2008
PubMed ID: 18413741
Association of interindividual differences in p14ARF promoter methylation with single nucleotide polymorphism in primary colorectal cancer.
Kang MY, Lee BB, Ji YI, Jung EH, Chun HK, Song SY, Park SE, Park J, Kim DH
Cancer. 2008
PubMed ID: 18327804
Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53.
Moulin S, Llanos S, Kim SH, Peters G
Oncogene. 2008
PubMed ID: 17968318
Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency.
Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P
Oncogene. 2008
PubMed ID: 17952114
p16 promoter hypermethylation: a useful serum marker for early detection of gastric cancer.
Abbaszadegan MR, Moaven O, Sima HR, Ghafarzadegan K, A'rabi A, Forghani MN, Raziee HR, Mashhadinejad A, Jafarzadeh M, Esmaili-Shandiz E, Dadkhah E
World J Gastroenterol. 2008
PubMed ID: 18395906
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.
Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L
Cancer Cell. 2008
PubMed ID: 18394558
Cyclin-dependent kinase inhibitor p16(INK4a) and telomerase may co-modulate endothelial progenitor cells senescence.
Yang DG, Liu L, Zheng XY
Ageing Res Rev. 2008
PubMed ID: 18343732
Trp53 deletion stimulates the formation of metastatic pancreatic tumors.
Morton JP, Klimstra DS, Mongeau ME, Lewis BC
Am J Pathol. 2008
PubMed ID: 18310506
Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early- and late-onset breast carcinoma.
Sinha S, Chunder N, Mukherjee N, Alam N, Roy A, Roychoudhury S, Kumar Panda C
Ann Surg Oncol. 2008
PubMed ID: 18239974
p16ink4 immunoreactivity is a reliable marker for urothelial carcinoma in situ.
Yin M, Bastacky S, Parwani AV, McHale T, Dhir R
Hum Pathol. 2008
PubMed ID: 18234280
Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia.
Horn LC, Reichert A, Oster A, Arndal SF, Trunk MJ, Ridder R, Rassmussen OF, Bjelkenkrantz K, Christiansen P, Eck M, Lorey T, Skovlund VR, Ruediger T, Schneider V, Schmidt D
Am J Surg Pathol. 2008
PubMed ID: 18223479
Evidence that senescent human prostate epithelial cells enhance tumorigenicity: cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT.
Bhatia B, Multani AS, Patrawala L, Chen X, Calhoun-Davis T, Zhou J, Schroeder L, Schneider-Broussard R, Shen J, Pathak S, Chang S, Tang DG
Int J Cancer. 2008
PubMed ID: 18059027
Molecular mechanism underlying the functional loss of cyclindependent kinase inhibitors p16 and p27 in hepatocellular carcinoma.
Matsuda Y
World J Gastroenterol. 2008
PubMed ID: 18350604
Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.
Baryshnikova E, Destro A, Infante MV, Cavuto S, Cariboni U, Alloisio M, Ceresoli GL, Lutman R, Brambilla G, Chiesa G, Ravasi G, Roncalli M
Clin Cancer Res. 2008
PubMed ID: 18347195
DNA methylation markers and early recurrence in stage I lung cancer.
Brock MV, Hooker CM, Ota-Machida E, Han Y, Guo M, Ames S, Glöckner S, Piantadosi S, Gabrielson E, Pridham G, Pelosky K, Belinsky SA, Yang SC, Baylin SB, Herman JG
N Engl J Med. 2008
PubMed ID: 18337602
CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF.
Kadaja-Saarepuu L, Laos S, Jääger K, Viil J, Balikova A, Lõoke M, Hansson GC, Maimets T
Oncogene. 2008
PubMed ID: 17891181
DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.
Feng Q, Hawes SE, Stern JE, Wiens L, Lu H, Dong ZM, Jordan CD, Kiviat NB, Vesselle H
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18349282
A conditional mouse model for malignant mesothelioma.
Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, van der Valk M, van de Vijver M, Berns A
Cancer Cell. 2008
PubMed ID: 18328429
DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway.
Yogev O, Saadon K, Anzi S, Inoue K, Shaulian E
Cancer Res. 2008
PubMed ID: 18316603
Chromosome 9 instability and alterations of p16 gene in squamous cell carcinoma of the lung and in adjacent normal bronchi: FISH and immunohistochemical study.
Dessy E, Rossi E, Berenzi A, Tironi A, Benetti A, Grigolato P
Histopathology. 2008
PubMed ID: 18315600
Uncommon association of germline mutations of RET proto-oncogene and CDKN2A gene.
Foppiani L, Forzano F, Ceccherini I, Bruno W, Ghiorzo P, Caroli F, Quilici P, Bandelloni R, Arlandini A, Sartini G, Cabria M, Del Monte P
Eur J Endocrinol. 2008
PubMed ID: 18299477
p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas.
O'Regan EM, Toner ME, Finn SP, Fan CY, Ring M, Hagmar B, Timon C, Smyth P, Cahill S, Flavin R, Sheils OM, O'Leary JJ
Hum Pathol. 2008
PubMed ID: 18261630
Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.
Cauchi S, Proença C, Choquet H, Gaget S, De Graeve F, Marre M, Balkau B, Tichet J, Meyre D, Vaxillaire M, Froguel P, D.E.S.I.R. Study Group
J Mol Med. 2008
PubMed ID: 18210030
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene.
Bagnyukova TV, Tryndyak VP, Montgomery B, Churchwell MI, Karpf AR, James SR, Muskhelishvili L, Beland FA, Pogribny IP
Carcinogenesis. 2008
PubMed ID: 18204080
Prevalence of mucosal and cutaneous human papillomaviruses in different histologic subtypes of vulvar carcinoma.
de Koning MN, Quint WG, Pirog EC
Mod Pathol. 2008
PubMed ID: 18192968
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
Omori S, Tanaka Y, Takahashi A, Hirose H, Kashiwagi A, Kaku K, Kawamori R, Nakamura Y, Maeda S
Diabetes. 2008
PubMed ID: 18162508
Poorly differentiated colorectal adenocarcinomas show higher rates of microsatellite instability and promoter methylation of p16 and hMLH1: a study matched for T classification and tumor location.
Kazama Y, Watanabe T, Kanazawa T, Tanaka J, Tanaka T, Nagawa H
J Surg Oncol. 2008
PubMed ID: 18161865
DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16(ink4A) down-regulation.
Guo Z, Tsai MH, Shiao YH, Chen LH, Wei ML, Lv X, Gius D, Little JB, Mitchell JB, Chuang EY
J Biomed Sci. 2008
PubMed ID: 18038118
Gene methylation in pleural mesothelioma: correlations with clinico-pathological features and patient's follow-up.
Destro A, Ceresoli GL, Baryshnikova E, Garassino I, Zucali PA, De Vincenzo F, Bianchi P, Morenghi E, Testori A, Alloisio M, Santoro A, Roncalli M
Lung Cancer. 2008
PubMed ID: 17920725
Promoter methylation of p16 and EDNRB gene in leukemia patients in Taiwan.
Hsiao PC, Liu MC, Chen LM, Tsai CY, Wang YT, Chen J, Hsu LS
Chin J Physiol. 2008
PubMed ID: 18551992
Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development.
Panattoni M, Sanvito F, Basso V, Doglioni C, Casorati G, Montini E, Bender JR, Mondino A, Pardi R
J Exp Med. 2008
PubMed ID: 18268034
Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival.
Song H, Hogdall E, Ramus SJ, Dicioccio RA, Hogdall C, Quaye L, McGuire V, Whittemore AS, Shah M, Greenberg D, Easton DF, Kjaer SK, Pharoah PD, Gayther SA
Clin Cancer Res. 2008
PubMed ID: 18281541
An endothelial cell genetic screen identifies the GTPase Rem2 as a suppressor of p19ARF expression that promotes endothelial cell proliferation and angiogenesis.
Bierings R, Beato M, Edel MJ
J Biol Chem. 2008
PubMed ID: 18056257
Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression.
Miyazaki M, Miyazaki K, Itoi M, Katoh Y, Guo Y, Kanno R, Katoh-Fukui Y, Honda H, Amagai T, van Lohuizen M, Kawamoto H, Kanno M
Immunity. 2008
PubMed ID: 18275833
Differential roles of p16INK4A and p14ARF genes in prognosis of oral carcinoma.
Sailasree R, Abhilash A, Sathyan KM, Nalinakumari KR, Thomas S, Kannan S
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18268126
TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.
Yarosh W, Barrientos T, Esmailpour T, Lin L, Carpenter PM, Osann K, Anton-Culver H, Huang T
Cancer Res. 2008
PubMed ID: 18245468
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells.
Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M, Conway SJ, Parada LF, Zhu Y, Morrison SJ
Cancer Cell. 2008
PubMed ID: 18242513
Expression of p16INK4a and MIB-1 in relation to histopathology and HPV types in cervical adenocarcinoma.
Muller S, Flores-Staino C, Skyldberg B, Hellström AC, Johansson B, Hagmar B, Wallin KL, Andersson S
Int J Oncol. 2008
PubMed ID: 18202755
Expression of cell cycle inhibitors p21, p27, p14 and p16 in gliomas. Correlation with classic prognostic factors and patients' outcome.
Zolota V, Tsamandas AC, Aroukatos P, Panagiotopoulos V, Maraziotis T, Poulos C, Scopa CD
Neuropathology. 2008
PubMed ID: 18181833
Application of flow cytometry for biomarker-based cervical cancer cells detection.
Ling J, Wiederkehr U, Cabiness S, Shroyer KR, Robinson JP
Diagn Cytopathol. 2008
PubMed ID: 18181189
Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.
Driver KE, Song H, Lesueur F, Ahmed S, Barbosa-Morais NL, Tyrer JP, Ponder BA, Easton DF, Pharoah PD, Dunning AM, Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) Team
Carcinogenesis. 2008
PubMed ID: 18174243
A non-tumor suppressor role for basal p19ARF in maintaining nucleolar structure and function.
Apicelli AJ, Maggi LB, Hirbe AC, Miceli AP, Olanich ME, Schulte-Winkeler CL, Saporita AJ, Kuchenreuther M, Sanchez J, Weilbaecher K, Weber JD
Mol Cell Biol. 2008
PubMed ID: 18070929
Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers.
Pacifico A, Goldberg LH, Peris K, Chimenti S, Leone G, Ananthaswamy HN
Br J Dermatol. 2008
PubMed ID: 18070208
Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.
Calés C, Román-Trufero M, Pavón L, Serrano I, Melgar T, Endoh M, Pérez C, Koseki H, Vidal M
Mol Cell Biol. 2008
PubMed ID: 18039844
Population-based prevalence of CDKN2A and CDK4 mutations in patients with multiple primary melanomas.
Helsing P, Nymoen DA, Ariansen S, Steine SJ, Maehle L, Aamdal S, Langmark F, Loeb M, Akslen LA, Molven A, Andresen PA
Genes Chromosomes Cancer. 2008
PubMed ID: 18023021
Germline CDKN2A/p16 mutations are rare in multiple primary and familial malignant melanoma in German patients.
Lukowsky A, Schäfer-Hesterberg G, Sterry W, Voit C
J Dermatol Sci. 2008
PubMed ID: 17890059
Clinical and molecular characterization of patients at risk for hereditary melanoma in southern Brazil.
Ashton-Prolla P, Bakos L, Junqueira G, Giugliani R, Azevedo SJ, Hogg D
J Invest Dermatol. 2008
PubMed ID: 17713569
Reactivation of methylation-silenced tumor suppressor gene p16INK4a by nordihydroguaiaretic acid and its implication in G1 cell cycle arrest.
Cui Y, Lu C, Liu L, Sun D, Yao N, Tan S, Bai S, Ma X
Life Sci. 2008
PubMed ID: 18164318
Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation.
Hallor KH, Staaf J, Jönsson G, Heidenblad M, Vult von Steyern F, Bauer HC, Ijszenga M, Hogendoorn PC, Mandahl N, Szuhai K, Mertens F
Br J Cancer. 2008
PubMed ID: 18071362
p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein.
Chen YW, Paliwal S, Draheim K, Grossman SR, Lewis BC
Cancer Res. 2008
PubMed ID: 18199542
p53-Dependent and p53-independent activation of autophagy by ARF.
Abida WM, Gu W
Cancer Res. 2008
PubMed ID: 18199527
Association between folate metabolism-related gene polymorphisms and methylation of p16(INK4A) and hMLH1 genes in spontaneously aborted embryos with normal chromosomal integrity.
Park HM, Shin SJ, Choi DH, Oh D, Lee S, Kim NK
Fertil Steril. 2008
PubMed ID: 18177869
Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens.
Muscarella P, Bloomston M, Brewer AR, Mahajan A, Frankel WL, Ellison EC, Farrar WB, Weghorst CM, Li J
Gene Expr. 2008
PubMed ID: 19110720
Aberrant expression of ID2 protein and its correlation with EBV-LMP1 and P16(INK4A) in classical Hodgkin lymphoma in China.
Zhao P, Lu Y, Liu L, Zhong M
BMC Cancer. 2008
PubMed ID: 19099554
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
Jeong JH, Wang Z, Guimaraes AS, Ouyang X, Figueiredo JL, Ding Z, Jiang S, Guney I, Kang GH, Shin E, Hahn WC, Loda MF, Abate-Shen C, Weissleder R, Chin L
PLoS ONE. 2008
PubMed ID: 19079609
p16 mutation spectrum in the premalignant condition Barrett's esophagus.
Paulson TG, Galipeau PC, Xu L, Kissel HD, Li X, Blount PL, Sanchez CA, Odze RD, Reid BJ
PLoS ONE. 2008
PubMed ID: 19043591
Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
Lee YH, Kang ES, Kim SH, Han SJ, Kim CH, Kim HJ, Ahn CW, Cha BS, Nam M, Nam CM, Lee HC
J Hum Genet. 2008
PubMed ID: 18991055
Nonparametric estimation of LOH using Affymetrix SNP genotyping arrays for unpaired samples.
Huggins R, Li LH, Lin YC, Yu AL, Yang HC
J Hum Genet. 2008
PubMed ID: 18989737
MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells.
Martin V, Jørgensen HF, Chaubert AS, Berger J, Barr H, Shaw P, Bird A, Chaubert P
Pathobiology. 2008
PubMed ID: 18931530
Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study.
Dehghan A, van Hoek M, Sijbrands EJ, Oostra BA, Hofman A, van Duijn CM, Witteman JC
BMC Med. 2008
PubMed ID: 18925945
Genome wide identification of recessive cancer genes by combinatorial mutation analysis.
Volinia S, Mascellani N, Marchesini J, Veronese A, Ormondroyd E, Alder H, Palatini J, Negrini M, Croce CM
PLoS ONE. 2008
PubMed ID: 18846217
Prevalence of variations in melanoma susceptibility genes among Slovenian melanoma families.
Peric B, Cerkovnik P, Novakovic S, Zgajnar J, Besic N, Hocevar M
BMC Med Genet. 2008
PubMed ID: 18803811
Overexpression of CyclinD1 and underexpression of p16 correlate with lymph node metastases in laryngeal squamous cell carcinoma in Chinese patients.
Fu ZJ, Ma ZY, Wang QR, Lei DP, Wang R, Liu CX, Pan XL
Clin Exp Metastasis. 2008
PubMed ID: 18787961
Expression of p21cip1, p27kip1, and p16INk4a cyclin-dependent kinase inhibitors in papillary thyroid carcinoma: correlation with clinicopathological factors.
Zafon C, Obiols G, Castellví J, Ramon y Cajal S, Baena JA, Mesa J
Endocr Pathol. 2008
PubMed ID: 18766473
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
Chrisanthar R, Knappskog S, Løkkevik E, Anker G, Østenstad B, Lundgren S, Berge EO, Risberg T, Mjaaland I, Maehle L, Engebretsen LF, Lillehaug JR, Lønning PE
PLoS ONE. 2008
PubMed ID: 18725978
Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.
Heathfield SK, Le Maitre CL, Hoyland JA
Arthritis Res Ther. 2008
PubMed ID: 18681962
High-resolution array copy number analyses for detection of deletion, gain, amplification and copy-neutral LOH in primary neuroblastoma tumors: four cases of homozygous deletions of the CDKN2A gene.
Carén H, Erichsen J, Olsson L, Enerbäck C, Sjöberg RM, Abrahamsson J, Kogner P, Martinsson T
BMC Genomics. 2008
PubMed ID: 18664255
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
PLoS ONE. 2008
PubMed ID: 18636124
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, Mehra NK, Mulvihill JJ, Ferrell RE, Nath SK, Kamboh MI
BMC Med Genet. 2008
PubMed ID: 18598350
Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors.
Almeida LO, Custódio AC, Araújo JJ, Rey JA, Almeida JR, Santos MJ, Clara CA, Casartelli C
Genet Mol Res. 2008
PubMed ID: 18551412
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
Cauchi S, Meyre D, Durand E, Proença C, Marre M, Hadjadj S, Choquet H, De Graeve F, Gaget S, Allegaert F, Delplanque J, Permutt MA, Wasson J, Blech I, Charpentier G, Balkau B, Vergnaud AC, Czernichow S, Patsch W, Chikri M, Glaser B, Sladek R, Froguel P
PLoS ONE. 2008
PubMed ID: 18461161
High-risk human papillomavirus infection and p16INK4a protein expression in laryngeal lesions.
Laco J, Slaninka I, Jirásek M, Celakovský P, Vosmiková H, Ryska A
Pathol Res Pract. 2008
PubMed ID: 18440161
Frequent and variable abnormalities in p14 tumor suppressor gene in glioma cell lines.
Tanaka Y, Zhang SJ, Terasaki H, Koga H, Endo S, Usui H, Washiyama K, Kumanishi T, Uematsu Y, Itakura T
Brain Tumor Pathol. 2008
PubMed ID: 18415661
Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines.
Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Takakura Y
In Vivo. 2008
PubMed ID: 18396777
The significance of immunohistochemical expression of Ki-67, p53, p21, and p16 in meningiomas tissue arrays.
Terzi A, Saglam EA, Barak A, Soylemezoglu F
Pathol Res Pract. 2008
PubMed ID: 18374497
p16(INK4a) translation suppressed by miR-24.
Lal A, Kim HH, Abdelmohsen K, Kuwano Y, Pullmann R, Srikantan S, Subrahmanyam R, Martindale JL, Yang X, Ahmed F, Navarro F, Dykxhoorn D, Lieberman J, Gorospe M
PLoS ONE. 2008
PubMed ID: 18365017
Expression of senescence-related genes in human corneal endothelial cells.
Song Z, Wang Y, Xie L, Zang X, Yin H
Mol Vis. 2008
PubMed ID: 18334933
Do different disorders in cell cycle regulation account for different biological behavior of urothelial and sinonasal inverted papillomas?
Gunia S, Fritzsche F, May M, Liebe D, Koch S
Pathobiology. 2008
PubMed ID: 18334838
Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers.
Brunner A, Verdorfer I, Prelog M, Mayerl C, Mikuz G, Tzankov A
Pathobiology. 2008
PubMed ID: 18334837
Immunoexpression of P16INK4a, Rb and TP53 proteins in bronchiolar columnar cell dysplasia (BCCD) in lungs resected due to primary non-small cell lung cancer.
Pankiewicz W, Sulewska A, Niklinska W, Naumnik W, Laudanski J, Niklinski J, Chyczewski L
Folia Histochem Cytobiol. 2008
PubMed ID: 18296270
Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma.
Wang J, Sasco AJ, Fu C, Xue H, Guo G, Hua Z, Zhou Q, Jiang Q, Xu B
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18199718
The Use of p16 in enhancing the histologic classification of uterine smooth muscle tumors.
Atkins KA, Arronte N, Darus CJ, Rice LW
Am J Surg Pathol. 2008
PubMed ID: 18162776
Differential Immunoreactivity of p16 in leiomyosarcomas and leiomyoma variants.
Gannon BR, Manduch M, Childs TJ
Int J Gynecol Pathol. 2008
PubMed ID: 18156978
Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss.
Debies MT, Gestl SA, Mathers JL, Mikse OR, Leonard TL, Moody SE, Chodosh LA, Cardiff RD, Gunther EJ
J Clin Invest. 2008
PubMed ID: 18060046
Expression of p16(INK4A) gene in human pituitary tumours.
Machiavelli G, Cotignola J, Danilowicz K, Carbonara C, Paes de Lima A, Basso A, Bruno OD, Szijan I
Pituitary. 2008
PubMed ID: 18058237
Natural history of meningioma development in mice reveals: a synergy of Nf2 and p16(Ink4a) mutations.
Kalamarides M, Stemmer-Rachamimov AO, Takahashi M, Han ZY, Chareyre F, Niwa-Kawakita M, Black PM, Carroll RS, Giovannini M
Brain Pathol. 2008
PubMed ID: 17924978
Diagnostic and prognostic markers for gastrointestinal stromal tumors in Norway.
Steigen SE, Bjerkehagen B, Haugland HK, Nordrum IS, Løberg EM, Isaksen V, Eide TJ, Nielsen TO
Mod Pathol. 2008
PubMed ID: 17917670
p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China.
Yan L, Na W, Shan K, Xiao-Wei M, Wei G, Shu-Cheng C
Int J Gynecol Cancer. 2008
PubMed ID: 17466040
Complex patterns of chromosome 9 alterations including the p16INK4a locus in Wilms tumours.
Natrajan R, Warren W, Messahel B, Reis-Filho JS, Brundler MA, Dome JS, Grundy PE, Vujanic G, Pritchard-Jones K, Jones C
J Clin Pathol. 2008
PubMed ID: 17369505
Two distinct pathways of p16 gene inactivation in gallbladder cancer.
Tadokoro H, Shigihara T, Ikeda T, Takase M, Suyama M
World J Gastroenterol. 2007
PubMed ID: 18081229
Epigenetic changes in the rat livers induced by pyrazinamide treatment.
Kovalenko VM, Bagnyukova TV, Sergienko OV, Bondarenko LB, Shayakhmetova GM, Matvienko AV, Pogribny IP
Toxicol Appl Pharmacol. 2007
PubMed ID: 17920094
Serine phosphorylation-dependent coregulation of topoisomerase I by the p14ARF tumor suppressor.
Bandyopadhyay K, Lee C, Haghighi A, Banères JL, Parello J, Gjerset RA
Biochemistry. 2007
PubMed ID: 18004878
Frequent homozygous deletion of p16/CDKN2A gene in malignant gliomas of Iranian patients.
Zadeh MD, Amini R, Firoozray M, Derakhshandeh-Peykar P
Pak J Biol Sci. 2007
PubMed ID: 19086579
[Role of HPV DNA detection and p16(INK4A) protein expression in diagnosis of endocervical adenocarcinoma]
Meng ZL, Guo LN, Luo YF, Cao JL, Wan JW, Liu TH
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 18346352
New doctorial cancer research: germline genetic alterations affecting CDKN2A, MDM2, and CDKN1A in melanoma and breast cancer patients.
Knappskog S
Crit Rev Oncog. 2007
PubMed ID: 18298387
Inactivation of p14ARF as a key event for the progression of adult T cell leukemia/lymphoma.
Kohno T, Yamada Y, Tawara M, Takasaki Y, Kamihira S, Tomonaga M, Matsuyama T
Leuk Res. 2007
PubMed ID: 18246599
Different trends of p53, MDM2 and p14 ARF expression patterns in endometrial adenocarcinomas versus hyperplasia.
Buchynska LG, Nesina IP, Kashuba EV
Exp Oncol. 2007
PubMed ID: 18199985
Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3.
Miki J, Fujimura Y, Koseki H, Kamijo T
Genes Cells. 2007
PubMed ID: 18076574
Reduced expression of p16 and p27 is correlated with tumour progression in cutaneous melanoma.
Sanki A, Li W, Colman M, Karim RZ, Thompson JF, Scolyer RA
Pathology. 2007
PubMed ID: 18027257
The p.G23S CDKN2A founder mutation in high-risk melanoma families from Central Italy.
Gensini F, Sestini R, Piazzini M, Vignoli M, Chiarugi A, Brandani P, Ghiorzo P, Salvini C, Borgognoni L, Palli D, Bianchi-Scarrà G, Carli P, Genuardi M
Melanoma Res. 2007
PubMed ID: 17992122
[Exploration of tumor suppressors p16INK4a and p14ARF in oral leukoplakias]
Nitsche M, Koy S, Mörz M, Koch R, Eckelt U
Mund Kiefer Gesichtschir. 2007
PubMed ID: 17990010
Frequent epigenetic inactivation of Rb1 in addition to p15 and p16 in mantle cell and follicular lymphoma.
Chim CS, Wong KY, Loong F, Lam WW, Srivastava G
Hum Pathol. 2007
PubMed ID: 17900658
Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells.
Kwok WK, Ling MT, Yuen HF, Wong YC, Wang X
Carcinogenesis. 2007
PubMed ID: 17690110
Does p16ink4a expression increase with the number of cell doublings in normal and malignant lymphocytes?
Chebel A, Chien WW, Gerland LM, Mekki Y, Bertrand Y, Ffrench P, Galmarini CM, Ffrench M
Leuk Res. 2007
PubMed ID: 17475325
The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1.
Burnworth B, Arendt S, Muffler S, Steinkraus V, Bröcker EB, Birek C, Hartschuh W, Jauch A, Boukamp P
Eur J Cell Biol. 2007
PubMed ID: 17198740
The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.
Cheng K, Grisendi S, Clohessy JG, Majid S, Bernardi R, Sportoletti P, Pandolfi PP
Oncogene. 2007
PubMed ID: 17546053
Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65.
Taneja P, Mallakin A, Matise LA, Frazier DP, Choudhary M, Inoue K
Oncogene. 2007
PubMed ID: 17546045
Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL
Clin Cancer Res. 2007
PubMed ID: 18006786
Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development.
Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, Kumasaka M, Denat L, Goodall J, Luciani F, Viros A, Demirkan N, Bastian BC, Goding CR, Larue L
Genes Dev. 2007
PubMed ID: 18006687
Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.
Mahajan A, Guo Y, Yuan C, Weghorst CM, Tsai MD, Li J
J Mol Biol. 2007
PubMed ID: 17881001
Interrelationships among chromosome aneuploidy, promoter hypermethylation, and protein expression of the CDKN2A gene in individuals from northern Brazil with gastric adenocarcinoma.
Guimarães AC, Lima EM, Khayat AS, Girão Faria MH, Barem Rabenhorst SH, Pitombeira MV, Assumpção PP, de Oliveira Bahia M, Lima de Lima PD, de Arruda Cardoso Smith M, Burbano RR
Cancer Genet Cytogenet. 2007
PubMed ID: 17981214
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
Bouchard C, Lee S, Paulus-Hock V, Loddenkemper C, Eilers M, Schmitt CA
Genes Dev. 2007
PubMed ID: 17974917
Proteomic analysis of p16ink4a-binding proteins.
Souza-Rodrígues E, Estanyol JM, Friedrich-Heineken E, Olmedo E, Vera J, Canela N, Brun S, Agell N, Hübscher U, Bachs O, Jaumot M
Proteomics. 2007
PubMed ID: 17955473
Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland.
Patel RS, Rose B, Bawdon H, Hong A, Lee CS, Fredericks S, Gao K, O'Brien CJ
Histopathology. 2007
PubMed ID: 17927591
Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck.
Suzuki N, Onda T, Yamamoto N, Katakura A, Mizoe JE, Shibahara T
Int J Oncol. 2007
PubMed ID: 17912431
Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas.
Fujii H, Honoki K, Tsujiuchi T, Kido A, Yoshitani K, Mori T, Takakura Y
Biochem Biophys Res Commun. 2007
PubMed ID: 17761140
Human p16gamma, a novel transcriptional variant of p16(INK4A), coexpresses with p16(INK4A) in cancer cells and inhibits cell-cycle progression.
Lin YC, Diccianni MB, Kim Y, Lin HH, Lee CH, Lin RJ, Joo SH, Li J, Chuang TJ, Yang AS, Kuo HH, Tsai MD, Yu AL
Oncogene. 2007
PubMed ID: 17486064
Consistent expression of the stem cell renewal factor BMI-1 in primary and metastatic melanoma.
Mihic-Probst D, Kuster A, Kilgus S, Bode-Lesniewska B, Ingold-Heppner B, Leung C, Storz M, Seifert B, Marino S, Schraml P, Dummer R, Moch H
Int J Cancer. 2007
PubMed ID: 17597110
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.
Reimann M, Loddenkemper C, Rudolph C, Schildhauer I, Teichmann B, Stein H, Schlegelberger B, Dörken B, Schmitt CA
Blood. 2007
PubMed ID: 17562874
The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.
Reef S, Shifman O, Oren M, Kimchi A
Oncogene. 2007
PubMed ID: 17486078
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
Mallakin A, Sugiyama T, Taneja P, Matise LA, Frazier DP, Choudhary M, Hawkins GA, D'Agostino RB, Willingham MC, Inoue K
Cancer Cell. 2007
PubMed ID: 17936562
Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.
Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M
Cancer Cell. 2007
PubMed ID: 17936558
Aberrant p16 promoter methylation among Greek lung cancer patients and smokers: correlation with smoking.
Georgiou E, Valeri R, Tzimagiorgis G, Anzel J, Krikelis D, Tsilikas C, Sarikos G, Destouni C, Dimitriadou A, Kouidou S
Eur J Cancer Prev. 2007
PubMed ID: 17923809
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.
Jones R, Ruas M, Gregory F, Moulin S, Delia D, Manoukian S, Rowe J, Brookes S, Peters G
Cancer Res. 2007
PubMed ID: 17909018
The clinical importance of Ki-67, p16, p14, and p57 expression in patients with advanced ovarian carcinoma.
Khouja MH, Baekelandt M, Nesland JM, Holm R
Int J Gynecol Pathol. 2007
PubMed ID: 17885492
Potent p53-independent tumor suppressor activity of ARF in melanoma-genesis.
Widlund HR, Fisher DE
Pigment Cell Res. 2007
PubMed ID: 17850505
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A
Blood. 2007
PubMed ID: 17507663
The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver.
Kostka G, Urbanek K, Ludwicki JK
Toxicology. 2007
PubMed ID: 17706854
Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.
Huang X, Shi Z, Wang W, Bai J, Chen Z, Xu J, Zhang D, Fu S
Biochem Biophys Res Commun. 2007
PubMed ID: 17658461
hAda3 regulates p14ARF-induced p53 acetylation and senescence.
Sekaric P, Shamanin VA, Luo J, Androphy EJ
Oncogene. 2007
PubMed ID: 17452980
Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma.
Tchougounova E, Kastemar M, Bråsäter D, Holland EC, Westermark B, Uhrbom L
Oncogene. 2007
PubMed ID: 17438529
Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia.
Williams RT, den Besten W, Sherr CJ
Genes Dev. 2007
PubMed ID: 17761812
p16INK4A-silencing augments DNA damage-induced apoptosis in cervical cancer cells.
Lau WM, Ho TH, Hui KM
Oncogene. 2007
PubMed ID: 17369842
Expression of cell cycle regulator p16 is not affected by diabetes during oral oncogenesis.
Vairaktaris E, Goutzanis L, Nkenke E, Spyridonidou S, Vassiliou S, Derka S, Vylliotis A, Yapijakis C, Lazaris A, Patsouris E
In Vivo. 2007
PubMed ID: 18019407
P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma.
Nakayama G, Hibi K, Kodera Y, Koike M, Fujiwara M, Nakao A
Anticancer Res. 2007
PubMed ID: 17970082
Promoter hypermethylation and quantitative expression analysis of CDKN2A (p14ARF and pl6INK4a) gene in esophageal squamous cell carcinoma.
Ito S, Ohga T, Saeki H, Watanabe M, Kakeji Y, Morita M, Yamada T, Maehara Y
Anticancer Res. 2007
PubMed ID: 17970080
Hypermethylation of p16INK4a in Korean non-small cell lung cancer patients.
Hong YS, Roh MS, Kim NY, Lee HJ, Kim HK, Lee KE, Kwak JY, Kim JY
J Korean Med Sci. 2007
PubMed ID: 17923752
P16(INK4a) immunocytochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear.
Monsonego J, Pollini G, Evrard MJ, Sednaoui P, Monfort L, Quinzat D, Dachez R, Syrjänen K
Acta Cytol. 2007
PubMed ID: 17910346
Sox10 has a broad expression pattern in gliomas and enhances platelet-derived growth factor-B--induced gliomagenesis.
Ferletta M, Uhrbom L, Olofsson T, Pontén F, Westermark B
Mol Cancer Res. 2007
PubMed ID: 17855658
Target cell frequency is a genetically determined risk factor in radiation leukaemogenesis.
Jawad M, Giotopoulos G, Cole C, Plumb M
Br J Radiol. 2007
PubMed ID: 17704327
Expression of Fhit, Mlh1, p16INK4A and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype.
Hara A, Yashima K, Yasugi A, Koda M, Kawaguchi K, Harada K, Andachi H, Shiota G, Ito H, Murawaki Y
Oncol Rep. 2007
PubMed ID: 17671701
[The molecular pathogenesis and prognosis of renal cell carcinoma]
Serth J
Urologe A. 2007
PubMed ID: 17668170
Hypermethylation of p14 (ARF) may be predictive of colitic cancer in patients with ulcerative colitis.
Moriyama T, Matsumoto T, Nakamura S, Jo Y, Mibu R, Yao T, Iida M
Dis Colon Rectum. 2007
PubMed ID: 17665255
Expression of the p16INK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion.
Shibata KR, Aoyama T, Shima Y, Fukiage K, Otsuka S, Furu M, Kohno Y, Ito K, Fujibayashi S, Neo M, Nakayama T, Nakamura T, Toguchida J
Stem Cells. 2007
PubMed ID: 17569790
Frequent intra-tumoural heterogeneity of promoter hypermethylation in malignant melanoma.
Rastetter M, Schagdarsurengin U, Lahtz C, Fiedler E, Marsch WCh, Dammann R, Helmbold P
Histol Histopathol. 2007
PubMed ID: 17523078
Evaluation of p16INK4a, minichromosome maintenance protein 2, DNA topoisomerase IIalpha, ProEX C, and p16INK4a/ProEX C in cervical squamous intraepithelial lesions.
Shi J, Liu H, Wilkerson M, Huang Y, Meschter S, Dupree W, Schuerch C, Lin F
Hum Pathol. 2007
PubMed ID: 17512033
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B
Nature. 2007
PubMed ID: 17728759
Activation of p53 by MEG3 non-coding RNA.
Zhou Y, Zhong Y, Wang Y, Zhang X, Batista DL, Gejman R, Ansell PJ, Zhao J, Weng C, Klibanski A
J Biol Chem. 2007
PubMed ID: 17569660
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a.
Krimpenfort P, Ijpenberg A, Song JY, van der Valk M, Nawijn M, Zevenhoven J, Berns A
Nature. 2007
PubMed ID: 17713536
LKB1 modulates lung cancer differentiation and metastasis.
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK
Nature. 2007
PubMed ID: 17676035
Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.
Chen YW, Klimstra DS, Mongeau ME, Tatem JL, Boyartchuk V, Lewis BC
Cancer Res. 2007
PubMed ID: 17699762
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.
Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D
Biochem Biophys Res Commun. 2007
PubMed ID: 17544373
TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation.
Pollice A, Sepe M, Villella VR, Tolino F, Vivo M, Calabrò V, La Mantia G
Oncogene. 2007
PubMed ID: 17334400
[Diagnostic value of p16INK4a in squamous intraepithelial lesion in gynecologic cytology]
Mei P, Liu YH, Zhuang HG, Luo XL, Xiao KL
Zhonghua Bing Li Xue Za Zhi. 2007
PubMed ID: 17980098
Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults.
Rajaraman P, Wang SS, Rothman N, Brown MM, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Chanock SJ, Inskip PD
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17684142
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T
Nat Med. 2007
PubMed ID: 17676052
Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray.
Liu YS, Yu CH, Li L, Zhang BF, Fang J, Zhou Q, Hu Y, Li YM, Jun Gao H
J Dig Dis. 2007
PubMed ID: 17650224
Essential role of stromally induced hedgehog signaling in B-cell malignancies.
Dierks C, Grbic J, Zirlik K, Beigi R, Englund NP, Guo GR, Veelken H, Engelhardt M, Mertelsmann R, Kelleher JF, Schultz P, Warmuth M
Nat Med. 2007
PubMed ID: 17632527
First detection of the melanoma-predisposing proline-48-threonine mutation of p16 in Hungarians: was there a common founder either in Italy or in Hungary?
Széll M, Balogh K, Dobozy A, Kemény L, Oláh J
Melanoma Res. 2007
PubMed ID: 17625456
Prognostic significance of p21WAF1/CIP1, p16INK4a and CD44s in tongue cancer.
González-Moles MA, Gil-Montoya JA, Ruiz-Avila I, Esteban F, Delgado-Rodriguez M, Bascones-Martinez A
Oncol Rep. 2007
PubMed ID: 17611661
Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways.
Ding L, Li L, Yang J, Zhou S, Li W, Tang M, Shi Y, Yi W, Cao Y
J Med Virol. 2007
PubMed ID: 17597480
The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Mol Endocrinol. 2007
PubMed ID: 17519353
New founder germline mutations of CDKN2A in melanoma-prone families and multiple primary melanoma development in a patient receiving levodopa treatment.
Kannengiesser C, Dalle S, Leccia MT, Avril MF, Bonadona V, Chompret A, Lasset C, Leroux D, Thomas L, Lesueur F, Lenoir G, Sarasin A, Bressac-de Paillerets B
Genes Chromosomes Cancer. 2007
PubMed ID: 17492760
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Salek C, Benesova L, Zavoral M, Nosek V, Kasperova L, Ryska M, Strnad R, Traboulsi E, Minarik M
World J Gastroenterol. 2007
PubMed ID: 17659731
Delayed ageing through damage protection by the Arf/p53 pathway.
Matheu A, Maraver A, Klatt P, Flores I, Garcia-Cao I, Borras C, Flores JM, Viña J, Blasco MA, Serrano M
Nature. 2007
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The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.
Linardic CM, Naini S, Herndon JE, Kesserwan C, Qualman SJ, Counter CM
Cancer Res. 2007
PubMed ID: 17638879
ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2.
Chang DL, Qiu W, Ying H, Zhang Y, Chen CY, Xiao ZX
Oncogene. 2007
PubMed ID: 17297463
[Prognostic value of P16 gene methylation and P16 protein expression in gastrointestinal stromal tumor]
Liang JF, Zheng HX, Li N, Cheng CX, Xiao H, Wang HK
Zhonghua Wei Chang Wai Ke Za Zhi. 2007
PubMed ID: 17659467
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.
Cánepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF
IUBMB Life. 2007
PubMed ID: 17654117
Aberrant methylation of multiple genes in gastric carcinomas.
Zhao YF, Zhang YG, Tian XX, Juan Du, Jie Zheng
Int J Surg Pathol. 2007
PubMed ID: 17652530
The association of p16(INK4A) and fragile histidine triad gene expression and cervical lesions.
Longatto-Filho A, Etlinger D, Pereira SM, Kanamura CT, di Loreto C, Santos Gda C, Makabe S, Marques JA, Santoro CL, das Dores GB, Castelo A
J Low Genit Tract Dis. 2007
PubMed ID: 17596760
Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon.
Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, Friso S, Choi SW
J Nutr. 2007
PubMed ID: 17585020
Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma.
Chiesa-Vottero AG, Malpica A, Deavers MT, Broaddus R, Nuovo GJ, Silva EG
Int J Gynecol Pathol. 2007
PubMed ID: 17581420
Abrogation of the p16-retinoblastoma-cyclin D1 pathway in head and neck squamous cell carcinomas.
Park HW, Song SY, Lee TJ, Jeong D, Lee TY
Oncol Rep. 2007
PubMed ID: 17549378
Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells.
André S, Sanchez-Ruderisch H, Nakagawa H, Buchholz M, Kopitz J, Forberich P, Kemmner W, Böck C, Deguchi K, Detjen KM, Wiedenmann B, von Knebel Doeberitz M, Gress TM, Nishimura S, Rosewicz S, Gabius HJ
FEBS J. 2007
PubMed ID: 17535296
Telomere dysfunction and inactivation of the p16(INK4a)/Rb pathway in pyothorax-associated lymphoma.
Tresnasari K, Takakuwa T, Ham MF, Rahadiani N, Nakajima H, Aozasa K
Cancer Sci. 2007
PubMed ID: 17428253
Analysis of exon 2 of MTS1 in HPV-positive and HPV-negative tumors of the head and neck region.
Fischer M
Eur Arch Otorhinolaryngol. 2007
PubMed ID: 17340131
The proximal GC-rich region of p16(INK4a) gene promoter plays a role in its transcriptional regulation.
Wang X, Feng Y, Pan L, Wang Y, Xu X, Lu J, Huang B
Mol Cell Biochem. 2007
PubMed ID: 17333389
PP2Cdelta (Ppm1d, WIP1), an endogenous inhibitor of p38 MAPK, is regulated along with Trp53 and Cdkn2a following p38 MAPK inhibition during mouse preimplantation development.
Hickson JA, Fong B, Watson PH, Watson AJ
Mol Reprod Dev. 2007
PubMed ID: 17219434
CDKN2A-positive breast cancers in young women from Poland.
Debniak T, Cybulski C, Górski B, Huzarski T, Byrski T, Gronwald J, Jakubowska A, Kowalska E, Oszurek O, Narod SA, Lubiński J
Breast Cancer Res Treat. 2007
PubMed ID: 17061045
ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.
Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17576930
Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome.
Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM
Mol Cell. 2007
PubMed ID: 17588519
Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT.
Brownhill SC, Taylor C, Burchill SA
Br J Cancer. 2007
PubMed ID: 17533400
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.
Mounawar M, Mukeria A, Le Calvez F, Hung RJ, Renard H, Cortot A, Bollart C, Zaridze D, Brennan P, Boffetta P, Brambilla E, Hainaut P
Cancer Res. 2007
PubMed ID: 17575133
Loss of xeroderma pigmentosum C (Xpc) enhances melanoma photocarcinogenesis in Ink4a-Arf-deficient mice.
Yang G, Curley D, Bosenberg MW, Tsao H
Cancer Res. 2007
PubMed ID: 17575131
A common allele on chromosome 9 associated with coronary heart disease.
McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC
Science. 2007
PubMed ID: 17478681
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K
Science. 2007
PubMed ID: 17478679
Association of p16INK4A hypermethylation with hepatitis B virus X protein expression in the early stage of HBV-associated hepatocarcinogenesis.
Zhu R, Li BZ, Li H, Ling YQ, Hu XQ, Zhai WR, Zhu HG
Pathol Int. 2007
PubMed ID: 17539963
The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain.
Mellert H, Sykes SM, Murphy ME, McMahon SB
Cell Cycle. 2007
PubMed ID: 17534149
CDKN2A and CDK4 variants in Latvian melanoma patients: analysis of a clinic-based population.
Pjanova D, Engele L, Randerson-Moor JA, Harland M, Bishop DT, Newton Bishop JA, Taylor C, Debniak T, Lubinski J, Kleina R, Heisele O
Melanoma Res. 2007
PubMed ID: 17505264
Analysis of p16 gene mutation, deletion and methylation in patients with arseniasis produced by indoor unventilated-stove coal usage in Guizhou, China.
Zhang AH, Bin HH, Pan XL, Xi XG
J Toxicol Environ Health A. 2007
PubMed ID: 17479413
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M
Science. 2007
PubMed ID: 17463248
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, Hughes TE, Groop L, Altshuler D, Almgren P, Florez JC, Meyer J, Ardlie K, Bengtsson Boström K, Isomaa B, Lettre G, Lindblad U, Lyon HN, Melander O, Newton-Cheh C, Nilsson P, Orho-Melander M, Råstam L, Speliotes EK, Taskinen MR, Tuomi T, Guiducci C, Berglund A, Carlson J, Gianniny L, Hackett R, Hall L, Holmkvist J, Laurila E, Sjögren M, Sterner M, Surti A, Svensson M, Svensson M, Tewhey R, Blumenstiel B, Parkin M, Defelice M, Barry R, Brodeur W, Camarata J, Chia N, Fava M, Gibbons J, Handsaker B, Healy C, Nguyen K, Gates C, Sougnez C, Gage D, Nizzari M, Gabriel SB, Chirn GW, Ma Q, Parikh H, Richardson D, Ricke D, Purcell S
Science. 2007
PubMed ID: 17463246
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G
Mol Cell Biol. 2007
PubMed ID: 17420273
Evaluation of a new p16(INK4A) ELISA test and a high-risk HPV DNA test for cervical cancer screening: results from proof-of-concept study.
Mao C, Balasubramanian A, Yu M, Kiviat N, Ridder R, Reichert A, Herkert M, von Knebel Doeberitz M, Koutsky LA
Int J Cancer. 2007
PubMed ID: 17294450
Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.
Li J, Sejas DP, Burma S, Chen DJ, Pang Q
Carcinogenesis. 2007
PubMed ID: 17277230
Novel CDKN2A mutations detected in western Swedish families with hereditary malignant melanoma.
Erlandson A, Appelqvist F, Wennberg AM, Holm J, Enerbäck C
J Invest Dermatol. 2007
PubMed ID: 17255954
Promoter hypermethylation profile of cell cycle regulator genes in pituitary adenomas.
Yoshino A, Katayama Y, Ogino A, Watanabe T, Yachi K, Ohta T, Komine C, Yokoyama T, Fukushima T
J Neurooncol. 2007
PubMed ID: 17216555
Functional characterization of human PFTK1 as a cyclin-dependent kinase.
Shu F, Lv S, Qin Y, Ma X, Wang X, Peng X, Luo Y, Xu BE, Sun X, Wu J
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17517622
Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians.
Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML
Clin Cancer Res. 2007
PubMed ID: 17505013
Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis.
Nilsson LM, Keller UB, Yang C, Nilsson JA, Cleveland JL, Roussel MF
Oncogene. 2007
PubMed ID: 17099725
[Expression and significance of P16INK4A and PTEN in high-risk human papillomavirus-related cervical cancer]
Zhao XL, Cheng SX, Kong XD
Ai Zheng. 2007
PubMed ID: 17672936
[Expressions of cyclin D1 and p16 in hypopharyngeal squamous cell carcinoma and their clinical significance].
Fu Z, Pan X, Lei D, Liu D, Liu W, Liu C, Wang R, Ye P
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007
PubMed ID: 17634024
p14ARF regulates E2F-1 ubiquitination and degradation via a p53-dependent mechanism.
Rizos H, Scurr LL, Irvine M, Alling NJ, Kefford RF
Cell Cycle. 2007
PubMed ID: 17630509
High-grade ovarian serous carcinoma exhibits significantly higher p16 expression than low-grade serous carcinoma and serous borderline tumour.
O'Neill CJ, McBride HA, Connolly LE, Deavers MT, Malpica A, McCluggage WG
Histopathology. 2007
PubMed ID: 17493241
Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis.
Nindl I, Gottschling M, Krawtchenko N, Lehmann MD, Röwert-Huber J, Eberle J, Stockfleth E, Forschner T
Br J Dermatol. 2007
PubMed ID: 17488404
p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts.
Carbone CJ, Graña X, Reddy EP, Haines DS
Cancer Res. 2007
PubMed ID: 17483323
A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, Song H, Khaw K, Luben R, Surtees PG, Bandinelli SS, Corsi AM, Ferrucci L, Guralnik JM, Wallace RB, Hattersley AT, Pharoah PD
Mech Ageing Dev. 2007
PubMed ID: 17459456
TBX3, the gene mutated in ulnar-mammary syndrome, promotes growth of mammary epithelial cells via repression of p19ARF, independently of p53.
Platonova N, Scotti M, Babich P, Bertoli G, Mento E, Meneghini V, Egeo A, Zucchi I, Merlo GR
Cell Tissue Res. 2007
PubMed ID: 17265068
CDKN2A germline mutations in individuals with cutaneous malignant melanoma.
Orlow I, Begg CB, Cotignola J, Roy P, Hummer AJ, Clas BA, Mujumdar U, Canchola R, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Wilcox H, Busam K, From L, Berwick M, GEM Study Group
J Invest Dermatol. 2007
PubMed ID: 17218939
Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses.
Mühlisch J, Bajanowski T, Rickert CH, Roggendorf W, Würthwein G, Jürgens H, Frühwald MC
J Neurooncol. 2007
PubMed ID: 17206475
Clinicopathological roles of alterations of tumor suppressor gene p16 in papillary thyroid carcinoma.
Lam AK, Lo CY, Leung P, Lang BH, Chan WF, Luk JM
Ann Surg Oncol. 2007
PubMed ID: 17195959
Promoter hypermethylation of p16INK4A, p14ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients.
Sharma G, Mirza S, Prasad CP, Srivastava A, Gupta SD, Ralhan R
Life Sci. 2007
PubMed ID: 17383681
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
Stecca B, Mas C, Clement V, Zbinden M, Correa R, Piguet V, Beermann F, Ruiz I Altaba A
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17392427
Simultaneous deregulation of p16 and cyclin D1 genes in pancreatic ductal adenocarcinoma: a combined immunohistochemistry and image analysis study based on tissue microarrays.
Tsiambas E, Karameris A, Gourgiotis S, Salemis N, Athanassiou AE, Karakitsos P, Papalois A, Merikas E, Kosmidis P, Patsouris E
J BUON. 2007
PubMed ID: 17600882
[Association of p16, p53, Ki-67 expressions with high-risk human papilloma virus infection in cervical intraepithelial neoplasia]
Shi J, Zheng JS, Yin F, Hu WW, Huang XJ, Zhou XL
Nan Fang Yi Ke Da Xue Xue Bao. 2007
PubMed ID: 17545048
Immunohistochemical expression of p16(INK4A) in normal uterine cervix, nonneoplastic epithelial lesions, and low-grade squamous intraepithelial lesions.
Focchi GR, Silva ID, Nogueira-de-Souza NC, Dobo C, Oshima CT, Stavale JN
J Low Genit Tract Dis. 2007
PubMed ID: 17415114
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.
Gayther SA, Song H, Ramus SJ, Kjaer SK, Whittemore AS, Quaye L, Tyrer J, Shadforth D, Hogdall E, Hogdall C, Blaeker J, DiCioccio R, McGuire V, Webb PM, Beesley J, Green AC, Whiteman DC, Australian Ovarian Cancer Study Group, Goodman MT, Lurie G, Carney ME, Modugno F, Ness RB, Edwards RP, Moysich KB, Goode EL, Couch FJ, Cunningham JM, Sellers TA, Wu AH, Pike MC, Iversen ES, Marks JR, Garcia-Closas M, Brinton L, Lissowska J, Peplonska B, Easton DF, Jacobs I, Ponder BA, Schildkraut J, Pearce CL, Chenevix-Trench G, Berchuck A, Pharoah PD, Ovarian Cancer Association Consortium
Cancer Res. 2007
PubMed ID: 17409409
HDM2-binding partners: interaction with translation elongation factor EF1alpha.
Frum R, Busby SA, Ramamoorthy M, Deb S, Shabanowitz J, Hunt DF, Deb SP
J Proteome Res. 2007
PubMed ID: 17373842
Mutation and expression analyses of the MET and CDKN2A genes in rhabdomyosarcoma with emphasis on MET overexpression.
Chen Y, Takita J, Mizuguchi M, Tanaka K, Ida K, Koh K, Igarashi T, Hanada R, Tanaka Y, Park MJ, Hayashi Y
Genes Chromosomes Cancer. 2007
PubMed ID: 17243166
Role of the chromobox protein CBX7 in lymphomagenesis.
Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martínez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17374722
Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran.
Abbaszadegan MR, Tavasoli A, Velayati A, Sima HR, Vosooghinia H, Farzadnia M, Asadzedeh H, Gholamin M, Dadkhah E, Aarabi A
World J Gastroenterol. 2007
PubMed ID: 17461444
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse.
Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360455
p14ARF interacts with N-Myc and inhibits its transcriptional activity.
Amente S, Gargano B, Diolaiti D, Della Valle G, Lania L, Majello B
FEBS Lett. 2007
PubMed ID: 17289033
[Analysis of the correlation between genetic and immunohistochemical markers (RB1, p16 and p53 gene regultors of a cell cycle) in sporadic mammary gland carcinoma]
Nemtsova MV, Zemliakova VV, Kuznetsova EV, Babenko OV, Zavalishina LE, Andreeva IuIu, Bateva MV, Frank GA, Zaletaev DV
Arkh Patol. 2007
PubMed ID: 17642181
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.
Bertheau P, Turpin E, Rickman DS, Espié M, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de Thé H
PLoS Med. 2007
PubMed ID: 17388661
Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction.
Rodríguez I, Coto E, Reguero JR, González P, Andrés V, Lozano I, Martín M, Alvarez V, Morís C
Cell Cycle. 2007
PubMed ID: 17351341
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K
Genes Dev. 2007
PubMed ID: 17344414
Low frequency of promoter methylation of O6-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.
Mikami T, Yoshida T, Numata Y, Shiraishi H, Araki K, Guiot MC, Jass JR, Okayasu I
Am J Clin Pathol. 2007
PubMed ID: 17276933
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Flores-Delgado G, Liu CW, Sposto R, Berndt N
J Proteome Res. 2007
PubMed ID: 17274640
The M53I mutation in CDKN2A is a founder mutation that predominates in melanoma patients with Scottish ancestry.
Lang J, Hayward N, Goldgar D, Tsao H, Hogg D, Palmer J, Stark M, Tobias ES, MacKie R
Genes Chromosomes Cancer. 2007
PubMed ID: 17171691
Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers.
Yu E, Ahn YS, Jang SJ, Kim MJ, Yoon HS, Gong G, Choi J
Breast Cancer Res Treat. 2007
PubMed ID: 16897432
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors.
Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M
Genes Dev. 2007
PubMed ID: 17299132
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.
Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH
Neuron. 2007
PubMed ID: 17296553
Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas.
Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber-Mangal S, Jauch A, Radlwimmer B, Schramm J, Wiestler OD, Lichter P, Reifenberger G
Oncogene. 2007
PubMed ID: 16909113
Effects of exogenous p16(ink4a) gene on biological behaviors of human lung cancer cells.
Zhang X, Jin Y, Tao X, Bai M
J Huazhong Univ Sci Technolog Med Sci. 2007
PubMed ID: 17393105
NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma.
Galipeau PC, Li X, Blount PL, Maley CC, Sanchez CA, Odze RD, Ayub K, Rabinovitch PS, Vaughan TL, Reid BJ
PLoS Med. 2007
PubMed ID: 17326708
Modeling INK4/ARF tumor suppression in the mouse.
Berger JH, Bardeesy N
Curr Mol Med. 2007
PubMed ID: 17311533
Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect.
Milyavsky M, Shats I, Cholostoy A, Brosh R, Buganim Y, Weisz L, Kogan I, Cohen M, Shatz M, Madar S, Kalo E, Goldfinger N, Yuan J, Ron S, MacKenzie K, Eden A, Rotter V
Cancer Cell. 2007
PubMed ID: 17292825
Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis.
Mo L, Zheng X, Huang HY, Shapiro E, Lepor H, Cordon-Cardo C, Sun TT, Wu XR
J Clin Invest. 2007
PubMed ID: 17256055
Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor.
Thornton JD, Swanson DJ, Mary MN, Pei D, Martin AC, Pounds S, Goldowitz D, Skapek SX
Invest Ophthalmol Vis Sci. 2007
PubMed ID: 17251441
Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT.
Haga K, Ohno S, Yugawa T, Narisawa-Saito M, Fujita M, Sakamoto M, Galloway DA, Kiyono T
Cancer Sci. 2007
PubMed ID: 17233832
Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Hong Y, Yang L, Li C, Xia H, Rhodus NL, Cheng B
Mol Carcinog. 2007
PubMed ID: 17091472
Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents.
Goldstein AM, Chan M, Harland M, Hayward NK, Demenais F, Bishop DT, Azizi E, Bergman W, Bianchi-Scarra G, Bruno W, Calista D, Albright LA, Chaudru V, Chompret A, Cuellar F, Elder DE, Ghiorzo P, Gillanders EM, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, MacKie RM, Magnusson V, Mann GJ, Bishop JN, Palmer JM, Puig S, Puig-Butille JA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E, Lund Melanoma Study Group, Melanoma Genetics Consortium (GenoMEL)
J Med Genet. 2007
PubMed ID: 16905682
Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaek
Kommoss S, du Bois A, Ridder R, Trunk MJ, Schmidt D, Pfisterer J, Kommoss F, AGO-OVAR
Br J Cancer. 2007
PubMed ID: 17242700
Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia.
Healy J, Bélanger H, Beaulieu P, Larivière M, Labuda D, Sinnett D
Blood. 2007
PubMed ID: 17008550
Regulation of the Arf tumor suppressor in Emicro-Myc transgenic mice: longitudinal study of Myc-induced lymphomagenesis.
Bertwistle D, Sherr CJ
Blood. 2007
PubMed ID: 16968893
A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
Tompkins VS, Hagen J, Frazier AA, Lushnikova T, Fitzgerald MP, di Tommaso A, Ladeveze V, Domann FE, Eischen CM, Quelle DE
J Biol Chem. 2007
PubMed ID: 17110379
[Alterations of cell cycle regulating proteins: Rb, p21 and p16 in laryngeal cancer]
Pietruszewska W, Durko M, Kobos J
Otolaryngol Pol. 2007
PubMed ID: 18546941
Alterations found in pl6/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium.
Vijayalakshmi N, Selvaluxmi G, Majhi U, Rajkumar T
Oncol Res. 2007
PubMed ID: 18306932
Microdeletions in 9p21.3 induce false negative results in CDKN2A FISH analysis of Ewing sarcoma.
Savola S, Nardi F, Scotlandi K, Picci P, Knuutila S
Cytogenet Genome Res. 2007
PubMed ID: 18160777
Two cases of uveal amelanotic melanoma in transgenic Tyr-HRAS+ Ink4a/Arf heterozygous mice.
Latendresse JR, Muskhelishvili L, Warbritton A, Tolleson WH
Toxicol Pathol. 2007
PubMed ID: 17987514
Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.
Tsou JA, Galler JS, Siegmund KD, Laird PW, Turla S, Cozen W, Hagen JA, Koss MN, Laird-Offringa IA
Mol Cancer. 2007
PubMed ID: 17967182
N-ethyl-N-nitrosourea (ENU)-induced meningiomatosis and meningioma in p16(INK4a)/p19(ARF) tumor suppressor gene-deficient mice.
Morrison JP, Satoh H, Foley J, Horton JL, Dunnick JK, Kissling GE, Malarkey DE
Toxicol Pathol. 2007
PubMed ID: 17943659
The ARF tumor suppressor in acute leukemias: insights from mouse models of Bcr-Abl-induced acute lymphoblastic leukemia.
Williams RT, Sherr CJ
Adv Exp Med Biol. 2007
PubMed ID: 17695724
Clinical significance of the detection of the homozygous deletion of P16 gene in malignant pleural effusion.
Gui S, Liu H, Zhang L, Zuo L, Zhou Q, Fei G, Wang Y
Intern Med. 2007
PubMed ID: 17675763
Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients.
Soreide K, Buter TC, Janssen EA, Gudlaugsson E, Skaland I, Körner H, Baak JP
Cell Oncol. 2007
PubMed ID: 17641414
BRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma.
Monnerat C, Chompret A, Kannengiesser C, Avril MF, Janin N, Spatz A, Guinebretière JM, Marian C, Barrois M, Boitier F, Lenoir GM, Bressac-de Paillerets B
Fam Cancer. 2007
PubMed ID: 17624602
Efficiency of immunohistochemical p16 expression and HPV typing in cervical squamous intraepithelial lesion grading and review of the p16 literature.
Yildiz IZ, Usubütün A, Firat P, Ayhan A, Küçükali T
Pathol Res Pract. 2007
PubMed ID: 17543474
P16(INK4a) overexpression independent of Human Papilloma Virus (HPV) infection in rare subtypes of endometrial carcinomas.
Giordano G, Azzoni C, D'Adda T, Merisio C
Pathol Res Pract. 2007
PubMed ID: 17498885
Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression.
Watanabe T, Katayama Y, Yoshino A, Yachi K, Ohta T, Ogino A, Komine C, Fukushima T
Brain Pathol. 2007
PubMed ID: 17493032
p16 is consistently expressed in endometrial tubal metaplasia.
Horree N, Heintz AP, Sie-Go DM, van Diest PJ
Cell Oncol. 2007
PubMed ID: 17429140
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3' UTR, and their association with clinical course of melanoma.
Lamperska KM, Przybyła A, Kycler W, Mackiewicz A
Acta Biochim Pol. 2007
PubMed ID: 17351674
Sp1 is essential for p16 expression in human diploid fibroblasts during senescence.
Wu J, Xue L, Weng M, Sun Y, Zhang Z, Wang W, Tong T
PLoS One. 2007
PubMed ID: 17225865
Caveolin-1(-/-)- and caveolin-2(-/-)-deficient mice both display numerous skeletal muscle abnormalities, with tubular aggregate formation.
Schubert W, Sotgia F, Cohen AW, Capozza F, Bonuccelli G, Bruno C, Minetti C, Bonilla E, Dimauro S, Lisanti MP
Am J Pathol. 2007
PubMed ID: 17200204
Different patterns of p16INK4A and p53 protein expressions in intraductal papillary-mucinous neoplasms and pancreatic intraepithelial neoplasia.
Abe K, Suda K, Arakawa A, Yamasaki S, Sonoue H, Mitani K, Nobukawa B
Pancreas. 2007
PubMed ID: 17198188
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
Jiao L, Zhu J, Hassan MM, Evans DB, Abbruzzese JL, Li D
Pancreas. 2007
PubMed ID: 17198183
A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment.
Gusarova GA, Wang IC, Major ML, Kalinichenko VV, Ackerson T, Petrovic V, Costa RH
J Clin Invest. 2007
PubMed ID: 17173139
A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions.
Zhu G, Montgomery GW, James MR, Trent JM, Hayward NK, Martin NG, Duffy DL
Eur J Hum Genet. 2007
PubMed ID: 17063143
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ, Anderson CW, Appella E, Bulavin DV
J Exp Med. 2006
PubMed ID: 17158963
The status of CDKN2A alpha (p16INK4A) and beta (p14ARF) transcripts in thyroid tumour progression.
Ferru A, Fromont G, Gibelin H, Guilhot J, Savagner F, Tourani JM, Kraimps JL, Larsen CJ, Karayan-Tapon L
Br J Cancer. 2006
PubMed ID: 17117177
DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.
Morey SR, Smiraglia DJ, James SR, Yu J, Moser MT, Foster BA, Karpf AR
Cancer Res. 2006
PubMed ID: 17178860
Physical and functional interaction of the p14ARF tumor suppressor with ribosomes.
Rizos H, McKenzie HA, Ayub AL, Woodruff S, Becker TM, Scurr LL, Stahl J, Kefford RF
J Biol Chem. 2006
PubMed ID: 17035234
Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation.
Ayrault O, Andrique L, Fauvin D, Eymin B, Gazzeri S, Séité P
Oncogene. 2006
PubMed ID: 16924243
The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma.
Bahnassy AA, Zekri AR, Alam El-Din HM, Aboubakr AA, Kamel K, El-Sabah MT, Mokhtar NM
J Egypt Natl Canc Inst. 2006
PubMed ID: 18301453
BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.
Yoon BS, Pogue R, Ovchinnikov DA, Yoshii I, Mishina Y, Behringer RR, Lyons KM
Development. 2006
PubMed ID: 17065231
A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family.
Knappskog S, Geisler J, Arnesen T, Lillehaug JR, Lønning PE
Genes Chromosomes Cancer. 2006
PubMed ID: 17001621
Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation.
Panić L, Tamarut S, Sticker-Jantscheff M, Barkić M, Solter D, Uzelac M, Grabusić K, Volarević S
Mol Cell Biol. 2006
PubMed ID: 17000767
MC1R common variants, CDKN2A and their association with melanoma and breast cancer risk.
Debniak T, Scott R, Masojc B, Serrano-Fernández P, Huzarski T, Byrski T, Debniak B, Górski B, Cybulski C, Medrek K, Kurzawski G, van de Wetering T, Maleszka R, Kładny J, Lubinski J
Int J Cancer. 2006
PubMed ID: 16988943
Methylation of the p16(INK4a) promoter region in telomerase immortalized human keratinocytes co-cultured with feeder cells.
Darbro BW, Lee KM, Nguyen NK, Domann FE, Klingelhutz AJ
Oncogene. 2006
PubMed ID: 16767161
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA
Genes Dev. 2006
PubMed ID: 17114584
Induction of p16INK4A mediated by beta-catenin in a TCF4-independent manner: implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells.
Saegusa M, Hashimura M, Kuwata T, Hamano M, Okayasu I
Int J Cancer. 2006
PubMed ID: 16858682
Homozygous deletions of the INK4a/ARF locus in renal cell cancer.
Kasahara T, Bilim V, Hara N, Takahashi K, Tomita Y
Anticancer Res. 2006
PubMed ID: 17201148
p16INK4A in oral squamous cell carcinomas--a correlation with biological behaviors: immunohistochemical and FISH analysis.
Suzuki H, Sugimura H, Hashimoto K
J Oral Maxillofac Surg. 2006
PubMed ID: 17052587
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E
Nat Cell Biol. 2006
PubMed ID: 17028578
A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.
Hume AN, Tarafder AK, Ramalho JS, Sviderskaya EV, Seabra MC
Mol Biol Cell. 2006
PubMed ID: 16914517
Genetic linkage analysis of pulmonary fibrotic response to silica in mice.
Ohtsuka Y, Wang XT, Saito J, Ishida T, Munakata M
Eur Respir J. 2006
PubMed ID: 16837500
Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa.
Kato K, Hara A, Kuno T, Mori H, Yamashita T, Toida M, Shibata T
J Cancer Res Clin Oncol. 2006
PubMed ID: 16791592
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.
Wasmeier C, Romao M, Plowright L, Bennett DC, Raposo G, Seabra MC
J Cell Biol. 2006
PubMed ID: 17043139
Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence.
Zhao P, Mao X, Talbot IC
World J Gastroenterol. 2006
PubMed ID: 17072968
High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL.
Goldstein AM, Chan M, Harland M, Gillanders EM, Hayward NK, Avril MF, Azizi E, Bianchi-Scarra G, Bishop DT, Bressac-de Paillerets B, Bruno W, Calista D, Cannon Albright LA, Demenais F, Elder DE, Ghiorzo P, Gruis NA, Hansson J, Hogg D, Holland EA, Kanetsky PA, Kefford RF, Landi MT, Lang J, Leachman SA, Mackie RM, Magnusson V, Mann GJ, Niendorf K, Newton Bishop J, Palmer JM, Puig S, Puig-Butille JA, de Snoo FA, Stark M, Tsao H, Tucker MA, Whitaker L, Yakobson E, Melanoma Genetics Consortium (GenoMEL)
Cancer Res. 2006
PubMed ID: 17047042
Alveolar cell senescence in patients with pulmonary emphysema.
Tsuji T, Aoshiba K, Nagai A
Am J Respir Crit Care Med. 2006
PubMed ID: 16888288
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.
Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H
J Exp Med. 2006
PubMed ID: 16954369
Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs.
Bian Y, Matsubayashi H, Li CP, Abe T, Canto M, Murphy KM, Goggins M
Cancer Biol Ther. 2006
PubMed ID: 17106238
[The expression of p53, p16, cyclin D1 in esophageal squamous cell carcinoma and esophageal dysplasia]
Kim SG, Hong SJ, Kwon KW, Jung SW, Kim WY, Jung IS, Ko BM, Ryu CB, Kim YS, Moon JH, Kim JO, Cho JY, Lee JS, Lee MS, Shim CS, Kim BS
Korean J Gastroenterol. 2006
PubMed ID: 17060721
Immunohistochemical detection of p16INK4a in dysplastic lesions of the oral cavity.
Bradley KT, Budnick SD, Logani S
Mod Pathol. 2006
PubMed ID: 16799478
Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression.
Zhang Z, Rosen DG, Yao JL, Huang J, Liu J
Mod Pathol. 2006
PubMed ID: 16799475
Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma.
Kraunz KS, Hsiung D, McClean MD, Liu M, Osanyingbemi J, Nelson HH, Kelsey KT
Int J Cancer. 2006
PubMed ID: 16646054
Expression of the cell cycle regulators p14(ARF) and p16(INK4a) in chronic myeloid leukemia.
Cividin M, Ayrault O, Sorel N, Séité P, Brizard F, Blanchet O, Mahon FX, Guilhot F, Larsen C, Chomel JC, Brizard A
Leuk Res. 2006
PubMed ID: 16533530
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing.
Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ
Nature. 2006
PubMed ID: 16957738
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT
Nature. 2006
PubMed ID: 16957735
Antiviral action of the tumor suppressor ARF.
García MA, Collado M, Muñoz-Fontela C, Matheu A, Marcos-Villar L, Arroyo J, Esteban M, Serrano M, Rivas C
EMBO J. 2006
PubMed ID: 16957780
Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma.
Ghiorzo P, Gargiulo S, Pastorino L, Nasti S, Cusano R, Bruno W, Gliori S, Sertoli MR, Burroni A, Savarino V, Gensini F, Sestini R, Queirolo P, Goldstein AM, Scarrà GB
Hum Mol Genet. 2006
PubMed ID: 16893909
Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.
Brücher BL, Geddert H, Langner C, Höfler H, Fink U, Siewert JR, Sarbia M
Int J Cancer. 2006
PubMed ID: 16619216
Tumour biology: Policing of oncogene activity by p53.
Efeyan A, Garcia-Cao I, Herranz D, Velasco-Miguel S, Serrano M
Nature. 2006
PubMed ID: 16971940
Carcinogen exposure and epigenetic silencing in bladder cancer.
Marsit CJ, Karagas MR, Schned A, Kelsey KT
Ann N Y Acad Sci. 2006
PubMed ID: 17119258
Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas.
Brinck U, Schlott T, Störber S, Stachura J, Bortkiewicz P, Nagel WD, Hasse FM, Cordon-Cardo C, Fischer G, Korabiowska M
Anticancer Res. 2006
PubMed ID: 17094467
Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma.
Fukuoka T, Hibi K, Nakao A
Anticancer Res. 2006
PubMed ID: 17094449
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
Simão Tde A, Simões GL, Ribeiro FS, Cidade DA, Andreollo NA, Lopes LR, Macedo JM, Acatauassu R, Teixeira AM, Felzenszwalb I, Pinto LF, Albano RM
Hum Exp Toxicol. 2006
PubMed ID: 17017004
Upper aerodigestive tract squamous dysplasia: correlation with p16, p53, pRb, and Ki-67 expression.
Wayne S, Robinson RA
Arch Pathol Lab Med. 2006
PubMed ID: 16948516
Specific contribution of p19(ARF) to nitric oxide-dependent apoptosis.
Zeini M, Través PG, López-Fontal R, Pantoja C, Matheu A, Serrano M, Boscá L, Hortelano S
J Immunol. 2006
PubMed ID: 16920973
DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer.
Gjerset RA
J Mol Histol. 2006
PubMed ID: 16855788
The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.
Kondo K, Takahashi Y, Hirose Y, Nagao T, Tsuyuguchi M, Hashimoto M, Ochiai A, Monden Y, Tangoku A
Lung Cancer. 2006
PubMed ID: 16828922
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD
J Biol Chem. 2006
PubMed ID: 16766534
Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway.
Chapman EJ, Hurst CD, Pitt E, Chambers P, Aveyard JS, Knowles MA
Oncogene. 2006
PubMed ID: 16619045
Sequence variants in cell cycle control pathway, X-ray exposure, and lung cancer risk: a multicenter case-control study in Central Europe.
Hung RJ, Boffetta P, Canzian F, Moullan N, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Landi S, Gemignani F, Hall J, Brennan P
Cancer Res. 2006
PubMed ID: 16912209
Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalization.
Dobrzycka KM, Kang K, Jiang S, Meyer R, Rao PH, Lee AV, Oesterreich S
Cancer Res. 2006
PubMed ID: 16912158
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.
Narita M, Narita M, Krizhanovsky V, Nuñez S, Chicas A, Hearn SA, Myers MP, Lowe SW
Cell. 2006
PubMed ID: 16901784
Expression of p16 and hTERT protein is associated with the presence of high-risk human papillomavirus in Bowenoid papulosis.
Liu H, Urabe K, Moroi Y, Yasumoto S, Kokuba H, Imafuku S, Koga T, Masuda T, Aburatani H, Furue M, Tu Y
J Cutan Pathol. 2006
PubMed ID: 16919029
Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms.
Finch A, Prescott J, Shchors K, Hunt A, Soucek L, Dansen TB, Swigart LB, Evan GI
Cancer Cell. 2006
PubMed ID: 16904610
The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study.
Berwick M, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Kanetsky PA, Busam K, From L, Mujumdar U, Wilcox H, Begg CB, GEM Study Group
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16896043
Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo.
Wendel HG, Malina A, Zhao Z, Zender L, Kogan SC, Cordon-Cardo C, Pelletier J, Lowe SW
Cancer Res. 2006
PubMed ID: 16885364
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D
Cancer Res. 2006
PubMed ID: 16885344
Intrinsic radiation resistance in human chondrosarcoma cells.
Moussavi-Harami F, Mollano A, Martin JA, Ayoob A, Domann FE, Gitelis S, Buckwalter JA
Biochem Biophys Res Commun. 2006
PubMed ID: 16765318
Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential.
Wiley A, Katsaros D, Chen H, Rigault de la Longrais IA, Beeghly A, Puopolo M, Singal R, Zhang Y, Amoako A, Zelterman D, Yu H
Cancer. 2006
PubMed ID: 16773633
p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation.
Leduc C, Claverie P, Eymin B, Col E, Khochbin S, Brambilla E, Gazzeri S
Oncogene. 2006
PubMed ID: 16501607
Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability.
Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y
J Biol Chem. 2006
PubMed ID: 16679321
The tumor suppressor p16Ink4a regulates T lymphocyte survival.
Bianchi T, Rufer N, MacDonald HR, Migliaccio M
Oncogene. 2006
PubMed ID: 16491120
Analysis of p16 expression and allelic imbalance / loss of heterozygosity of 9p21 in cutaneous squamous cell carcinomas.
Gray SE, Kay E, Leader M, Mabruk M
J Cell Mol Med. 2006
PubMed ID: 16989737
p53-induced apoptosis occurs in the absence of p14(ARF) in malignant pleural mesothelioma.
Hopkins-Donaldson S, Belyanskaya LL, Simões-Wüst AP, Sigrist B, Kurtz S, Zangemeister-Wittke U, Stahel R
Neoplasia. 2006
PubMed ID: 16867217
Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest.
Nitta RT, Jameson SA, Kudlow BA, Conlan LA, Kennedy BK
Mol Cell Biol. 2006
PubMed ID: 16809772
Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6.
Nonomura Y, Nagasaka K, Hagiyama H, Sekine C, Nanki T, Tamamori-Adachi M, Miyasaka N, Kohsaka H
Arthritis Rheum. 2006
PubMed ID: 16802342
Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas.
Simon M, Voss D, Park-Simon TW, Mahlberg R, Köster G
Oncol Rep. 2006
PubMed ID: 16786135
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".
Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K
Mol Cell Biol. 2006
PubMed ID: 16782892
Inactivation of p16INK4a (inhibitor of cyclin-dependent kinase 4A) immortalizes primary human keratinocytes by maintaining cells in the stem cell compartment.
Maurelli R, Zambruno G, Guerra L, Abbruzzese C, Dimri G, Gellini M, Bondanza S, Dellambra E
FASEB J. 2006
PubMed ID: 16754749
Persistent infection of hepatitis B virus is involved in high rate of p16 methylation in hepatocellular carcinoma.
Jicai Z, Zongtao Y, Zongtao Y, Jun L, Jun L, Haiping L, Jianmin W, Lihua H
Mol Carcinog. 2006
PubMed ID: 16649250
Role of INK4a locus in normal eye development and cataract genesis.
Cheong C, Sung YH, Lee J, Choi YS, Song J, Kee C, Lee HW
Mech Ageing Dev. 2006
PubMed ID: 16620915
The A148T variant of the CDKN2A gene is not associated with melanoma risk in the French and Italian populations.
Spica T, Portela M, Gérard B, Formicone F, Descamps V, Crickx B, Ollivaud L, Archimbaud A, Dupin N, Wolkenstein P, Vitoux D, Lebbe C, Saiag P, Basset-Seguin N, Fargnoli MC, Grandchamp B, Peris K, Soufir N, MELAN-COHORT
J Invest Dermatol. 2006
PubMed ID: 16614725
p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription.
Wang CH, Chang HC, Hung WC
J Cell Physiol. 2006
PubMed ID: 16575904
Analysis of MTHFR polymorphisms and P16 methylation and their correlation with clinical-biological features of multiple myeloma.
Chiusolo P, Farina G, Putzulu R, Reddiconto G, Fiorini A, De Stefano V, Rossi E, Palladino M, Leone G, Sica S
Ann Hematol. 2006
PubMed ID: 16541270
Decreased Mdm2 expression inhibits tumor development induced by loss of ARF.
Wang P, Greiner TC, Lushnikova T, Eischen CM
Oncogene. 2006
PubMed ID: 16491126
CDKN2A common variant and multi-organ cancer risk--a population-based study.
Debniak T, Scott RJ, Huzarski T, Byrski T, Rozmiarek A, Debniak B, Górski B, Cybulski C, Medrek K, Mierzejewski M, Masojc B, Matyjasik J, Złowocka E, Teodorczyk U, Lener M, Klujszo-Grabowska E, Nej-Wołosiak K, Jaworowska E, Oszutowska D, Szymańska A, Szymańska J, Castaneda J, van de Wetering T, Suchy J, Kurzawski G, Oszurek O, Narod S, Lubinski J
Int J Cancer. 2006
PubMed ID: 16395703
Expression of the cell cycle regulators p53, p21(WAF1/CIP1) and p16(INK4a) in human endometrial adenocarcinoma.
Buchynska LG, Nesina IP
Exp Oncol. 2006
PubMed ID: 16837908
Induction of the tumor-suppressor p16(INK4a) within regenerative epithelial crypts in ulcerative colitis.
Furth EE, Gustafson KS, Dai CY, Gibson SL, Menard-Katcher P, Chen T, Koh J, Enders GH
Neoplasia. 2006
PubMed ID: 16820088
Methylation of p16INK4a is a non-rare event in cervical intraepithelial neoplasia.
Kang S, Kim J, Kim HB, Shim JW, Nam E, Kim SH, Ahn HJ, Choi YP, Ding B, Song K, Cho NH
Diagn Mol Pathol. 2006
PubMed ID: 16778587
The rat ARF protein is translated from two closely spaced ATG start codons and can transcriptionally activate p53 in the absence of p53 protein stabilization.
Hunt AE, Moule MG, Fried M
Cell Cycle. 2006
PubMed ID: 16760664
Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.
Bazan V, Bruno L, Augello C, Agnese V, Calò V, Corsale S, Gargano G, Terrasi M, Schirò V, Di Fede G, Adamo V, Intrivici C, Crosta A, Rinaldi G, Latteri F, Dardanoni G, Grassi N, Valerio MR, Colucci G, Macaluso M, Russo A, Gruppo Oncologico dell'Italia Meridionale
Ann Oncol. 2006
PubMed ID: 16760301
A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence.
Natarajan E, Omobono JD, Guo Z, Hopkinson S, Lazar AJ, Brenn T, Jones JC, Rheinwald JG
Am J Pathol. 2006
PubMed ID: 16723698
p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.
Eymin B, Claverie P, Salon C, Leduc C, Col E, Brambilla E, Khochbin S, Gazzeri S
Mol Cell Biol. 2006
PubMed ID: 16705183
TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.
Augello C, Gregorio V, Bazan V, Cammareri P, Agnese V, Cascio S, Corsale S, Calò V, Gullo A, Passantino R, Gargano G, Bruno L, Rinaldi G, Morello V, Gerbino A, Tomasino RM, Macaluso M, Surmacz E, Russo A
J Cell Physiol. 2006
PubMed ID: 16447252
Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction.
Hassan GS, Williams TM, Frank PG, Lisanti MP
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16415072
p14ARF and p16INK4A, two products of the same gene, are differently expressed in cervical intraepithelial neoplasia.
Bulten J, van der Avoort IA, Melchers WJ, Massuger LF, Grefte JM, Hanselaar AG, de Wilde PC
Gynecol Oncol. 2006
PubMed ID: 16406113
The expression of p16INK4a tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication.
Zannetti C, Mondini M, De Andrea M, Caposio P, Hara E, Peters G, Gribaudo G, Gariglio M, Landolfo S
Virology. 2006
PubMed ID: 16504234
A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.
Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, Kimchi A
Mol Cell. 2006
PubMed ID: 16713577
p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.
Shank-Calvo JA, Draheim K, Bhasin M, Kelliher MA
Oncogene. 2006
PubMed ID: 16407836
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.
Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M, Wong KK
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16672372
Lack of Rb and p53 delays cerebellar development and predisposes to large cell anaplastic medulloblastoma through amplification of N-Myc and Ptch2.
Shakhova O, Leung C, van Montfort E, Berns A, Marino S
Cancer Res. 2006
PubMed ID: 16707443
Loss of p16 in recurrent malignant mixed müllerian tumors of the uterus.
Robinson-Bennett B, Belch RZ, Han AC
Int J Gynecol Cancer. 2006
PubMed ID: 16803529
[The relationship between methylation of p16 INK 4/CDKN2 gene in promoter region and progress of squamous cell carcinoma of buccal mucosa]
Dong YY, Wang J, Dong FS, Wang X, Li HX, Gu HT
Zhonghua Kou Qiang Yi Xue Za Zhi. 2006
PubMed ID: 16784614
The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans.
Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA
Cancer Cell. 2006
PubMed ID: 16697958
Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas.
Arifin MT, Hama S, Kajiwara Y, Sugiyama K, Saito T, Matsuura S, Yamasaki F, Arita K, Kurisu K
J Neurooncol. 2006
PubMed ID: 16614947
Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma.
Kraunz KS, McClean MD, Nelson HH, Peters E, Calderon H, Kelsey KT
Cancer Res. 2006
PubMed ID: 16618779
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16585505
p16INK4a overexpression independent of human papillomavirus infection in lobular endocervical glandular hyperplasia.
Hashi A, Xu JY, Kondo T, Hashi K, Yuminamochi T, Nara M, Murata S, Katoh R, Hoshi K
Int J Gynecol Pathol. 2006
PubMed ID: 16633071
p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix.
Horn LC, Lindner K, Szepankiewicz G, Edelmann J, Hentschel B, Tannapfel A, Bilek K, Liebert UG, Richter CE, Einenkel J, Leo C
Int J Gynecol Pathol. 2006
PubMed ID: 16633070
Regulation of p14ARF through subnuclear compartmentalization.
Gjerset RA, Bandyopadhyay K
Cell Cycle. 2006
PubMed ID: 16627991
High promoter hypermethylation frequency of p14/ARF in supratentorial PNET but not in medulloblastoma.
Inda MM, Muñoz J, Coullin P, Fauvet D, Danglot G, Tuñón T, Bernheim A, Castresana JS
Histopathology. 2006
PubMed ID: 16623784
Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma.
Worsham MJ, Chen KM, Tiwari N, Pals G, Schouten JP, Sethi S, Benninger MS
Arch Otolaryngol Head Neck Surg. 2006
PubMed ID: 16618910
p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions.
Goumenou AG, Matalliotakis IM, Tzardi M, Fragouli IG, Mahutte NG, Arici A
Fertil Steril. 2006
PubMed ID: 16616093
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation.
Eymin B, Claverie P, Salon C, Brambilla C, Brambilla E, Gazzeri S
Cell Cycle. 2006
PubMed ID: 16582626
Retinoblastoma family proteins: insights gained through genetic manipulation of mice.
Wikenheiser-Brokamp KA
Cell Mol Life Sci. 2006
PubMed ID: 16465443
p16INK4A expression in cervical premalignant and malignant lesions.
Lambert AP, Anschau F, Schmitt VM
Exp Mol Pathol. 2006
PubMed ID: 16257403
Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53.
Chen J, Huang X, Halicka D, Brodsky S, Avram A, Eskander J, Bloomgarden NA, Darzynkiewicz Z, Goligorsky MS
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16243918
Oncogenic activity of Cdc6 through repression of the INK4/ARF locus.
Gonzalez S, Klatt P, Delgado S, Conde E, Lopez-Rios F, Sanchez-Cespedes M, Mendez J, Antequera F, Serrano M
Nature. 2006
PubMed ID: 16572177
Neosquamous epithelium does not typically arise from Barrett's epithelium.
Paulson TG, Xu L, Sanchez C, Blount PL, Ayub K, Odze RD, Reid BJ
Clin Cancer Res. 2006
PubMed ID: 16551852
An inducible mouse model of melanoma expressing a defined tumor antigen.
Huijbers IJ, Krimpenfort P, Chomez P, van der Valk MA, Song JY, Inderberg-Suso EM, Schmitt-Verhulst AM, Berns A, Van den Eynde BJ
Cancer Res. 2006
PubMed ID: 16540681
Homozygous deletion of p16INK4a and tobacco carcinogen exposure in nonsmall cell lung cancer.
Kraunz KS, Nelson HH, Lemos M, Godleski JJ, Wiencke JK, Kelsey KT
Int J Cancer. 2006
PubMed ID: 16184554
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a).
Guney I, Wu S, Sedivy JM
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537449
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC
Nature. 2006
PubMed ID: 16400328
Promoter methylation profile in gallbladder cancer.
Roa JC, Anabalón L, Roa I, Melo A, Araya JC, Tapia O, de Aretxabala X, Muñoz S, Schneider B
J Gastroenterol. 2006
PubMed ID: 16699861
Identification of novel ARF binding proteins by two-hybrid screening.
Tompkins V, Hagen J, Zediak VP, Quelle DE
Cell Cycle. 2006
PubMed ID: 16582619
Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.
van Schanke A, van Venrooij GM, Jongsma MJ, Banus HA, Mullenders LH, van Kranen HJ, de Gruijl FR
Cancer Res. 2006
PubMed ID: 16510579
p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.
McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD
PLoS Biol. 2006
PubMed ID: 16464125
Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions.
Benevolo M, Mottolese M, Marandino F, Vocaturo G, Sindico R, Piperno G, Mariani L, Sperduti I, Canalini P, Donnorso RP, Vocaturo A
Mod Pathol. 2006
PubMed ID: 16415792
Mutational and methylation analysis of the cyclin-dependent kinase 4 inhibitor (p16INK4A) gene in chronic lymphocytic leukemia.
Tsirigotis P, Pappa V, Labropoulos S, Papageorgiou S, Kontsioti F, Dervenoulas J, Papageorgiou E, Panani A, Mantzios G, Economopoulos T, Raptis S
Eur J Haematol. 2006
PubMed ID: 16412137
p14ARF directly interacts with Myc through the Myc BoxII domain.
Amente S, Gargano B, Varrone F, Ruggiero L, Dominguez-Sola D, Lania L, Majello B
Cancer Biol Ther. 2006
PubMed ID: 16410719
Early loss of proliferative potential of human peritoneal mesothelial cells in culture: the role of p16INK4a-mediated premature senescence.
Ksiazek K, Piwocka K, Brzezińska A, Sikora E, Zabel M, Breborowicz A, Jörres A, Witowski J
J Appl Physiol. 2006
PubMed ID: 16254068
p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients.
Ulivi P, Zoli W, Calistri D, Fabbri F, Tesei A, Rosetti M, Mengozzi M, Amadori D
J Cell Physiol. 2006
PubMed ID: 16222700
Subcellular localization, modification and protein complex formation of the cdk-inhibitor p16 in Rb-functional and Rb-inactivated tumor cells.
Nilsson K, Landberg G
Int J Cancer. 2006
PubMed ID: 16161044
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, Field JK, Risk JM
Br J Cancer. 2006
PubMed ID: 16449996
E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway.
Russell JL, Weaks RL, Berton TR, Johnson DG
Oncogene. 2006
PubMed ID: 16205640
Expression of p53, p16 and COX-2 in pancreatic cancer with tissue microarray.
Xu L, Li YM, Yu CH, Li L, Liu YS, Zhang BF, Fang J, Zhou Q, Hu Y, Gao HJ
Hepatobiliary Pancreat Dis Int. 2006
PubMed ID: 16481301
Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.
Shiio Y, Rose DW, Aur R, Donohoe S, Aebersold R, Eisenman RN
Mol Cell Biol. 2006
PubMed ID: 16449650
Germline CDKN2A mutations among Greek patients with early-onset and multiple primary cutaneous melanoma.
Stratigos AJ, Yang G, Dimisianos R, Nicolaou V, Stefanaki I, Katsambas AD, Tsao H
J Invest Dermatol. 2006
PubMed ID: 16374456
Methylation of the INK4A/ARF locus in blood mononuclear cells.
Deligezer U, Erten N, Akisik EE, Dalay N
Ann Hematol. 2006
PubMed ID: 16320052
p16INK4a and p14ARF methylation as a potential biomarker for human bladder cancer.
Kawamoto K, Enokida H, Gotanda T, Kubo H, Nishiyama K, Kawahara M, Nakagawa M
Biochem Biophys Res Commun. 2006
PubMed ID: 16316628
Cell cycle inhibitors p21 and p16 are required for the regulation of Schwann cell proliferation.
Atanasoski S, Boller D, De Ventura L, Koegel H, Boentert M, Young P, Werner S, Suter U
Glia. 2006
PubMed ID: 16206162
Hypermethylation of the p16 gene promoter in pterygia and its association with the expression of DNA methyltransferase 3b.
Chen PL, Cheng YW, Chiang CC, Tseng SH, Chau PS, Tsai YY
Mol Vis. 2006
PubMed ID: 17149367
Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva.
Nogueira MC, Guedes Neto Ede P, Rosa MW, Zettler E, Zettler CG
Pathol Oncol Res. 2006
PubMed ID: 16998595
Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer.
Lee M, Sup Han W, Kyoung Kim O, Hee Sung S, Sun Cho M, Lee SN, Koo H
Pathol Res Pract. 2006
PubMed ID: 16675157
Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients.
Liu Y, Lan Q, Siegfried JM, Luketich JD, Keohavong P
Neoplasia. 2006
PubMed ID: 16533425
[Promotor hypermethylation of E-cadherin, p16 and estrogen receptor in prostate carcinoma].
Yao Q, He XS, Zhang JM, He J
Zhonghua Nan Ke Xue. 2006
PubMed ID: 16483154
Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci.
Stylianou IM, Korstanje R, Li R, Sheehan S, Paigen B, Churchill GA
Mamm Genome. 2006
PubMed ID: 16416088
Methylation of p16(INK4A) and p57(KIP2) are involved in the development and progression of gastric MALT lymphomas.
Min KO, Seo EJ, Kwon HJ, Lee EJ, Kim WI, Kang CS, Kim KM
Mod Pathol. 2006
PubMed ID: 16357845
Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma.
Laud K, Marian C, Avril MF, Barrois M, Chompret A, Goldstein AM, Tucker MA, Clark PA, Peters G, Chaudru V, Demenais F, Spatz A, Smith MW, Lenoir GM, Bressac-de Paillerets B, French Hereditary Melanoma Study Group
J Med Genet. 2006
PubMed ID: 15937071
Regulation of the INK4a/ARF locus by histone deacetylase inhibitors.
Matheu A, Klatt P, Serrano M
J Biol Chem. 2005
PubMed ID: 16251190
The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.
Moreno-Miralles I, Pan L, Keates-Baleeiro J, Durst-Goodwin K, Yang C, Kim HG, Thompson MA, Klug CA, Cleveland JL, Hiebert SW
J Biol Chem. 2005
PubMed ID: 16199529
Nevus distribution in a Utah melanoma kindred with a temperature-sensitive CDKN2A mutation.
Florell SR, Meyer LJ, Boucher KM, Hart M, Cannon-Albright LA, Harris RM, Grossman D, Samlowski WE, Zone JJ, Brinton JP, Leachman SA
J Invest Dermatol. 2005
PubMed ID: 16354203
p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors.
Gibson SL, Boquoi A, Chen T, Sharpless NE, Brensinger C, Enders GH
Cancer Biol Ther. 2005
PubMed ID: 16322687
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
Pascale RM, Simile MM, Calvisi DF, Frau M, Muroni MR, Seddaiu MA, Daino L, Muntoni MD, De Miglio MR, Thorgeirsson SS, Feo F
Hepatology. 2005
PubMed ID: 16317707
Age does not appear to be a major indicator of CDKN2A or CDK4 mutations in melanoma patients in Spain.
Nagore E, Montoro A, Oltra S, Ledesma E, Botella-Estrada R, Millán JM, Oliver V, Fortea JM, Guillén C
Melanoma Res. 2005
PubMed ID: 16314743
Association of genetic polymorphisms of MK, IL-4, p16, p21, p53 genes and human gastric cancer in Taiwan.
Lai KC, Chen WC, Jeng LB, Li SY, Chou MC, Tsai FJ
Eur J Surg Oncol. 2005
PubMed ID: 16289646
Cell-cycle-associated markers and clinical outcome in human epithelial cancers: a tissue microarray study.
Abdulkader I, Sánchez L, Cameselle-Teijeiro J, Gude F, Chávez JE, López-López R, Forteza J, Fraga M
Oncol Rep. 2005
PubMed ID: 16273250
Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.
Jerome-Majewska LA, Jenkins GP, Ernstoff E, Zindy F, Sherr CJ, Papaioannou VE
Dev Dyn. 2005
PubMed ID: 16222716
Polymorphism of p16 INK4A and cyclin D1 in adenocarcinomas of the upper gastrointestinal tract.
Geddert H, Kiel S, Zotz RB, Zhang J, Willers R, Gabbert HE, Sarbia M
J Cancer Res Clin Oncol. 2005
PubMed ID: 16163549
Somatic integration of an oncogene-harboring Sleeping Beauty transposon models liver tumor development in the mouse.
Carlson CM, Frandsen JL, Kirchhof N, McIvor RS, Largaespada DA
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16286660
Loss of the hSNF5 gene concomitantly inactivates p21CIP/WAF1 and p16INK4a activity associated with replicative senescence in A204 rhabdoid tumor cells.
Chai J, Charboneau AL, Betz BL, Weissman BE
Cancer Res. 2005
PubMed ID: 16288006
Distinct E2F-mediated transcriptional program regulates p14ARF gene expression.
Komori H, Enomoto M, Nakamura M, Iwanaga R, Ohtani K
EMBO J. 2005
PubMed ID: 16211008
Mitochondrially targeted p53 has tumor suppressor activities in vivo.
Talos F, Petrenko O, Mena P, Moll UM
Cancer Res. 2005
PubMed ID: 16267022
Effect of promoter methylation of the p16 gene on phosphorylation of retinoblastoma gene product and growth of hepatocellular carcinoma cells.
Maeta Y, Shiota G, Okano J, Murawaki Y
Tumour Biol. 2005
PubMed ID: 16254459
PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a.
Gizard F, Amant C, Barbier O, Bellosta S, Robillard R, Percevault F, Sevestre H, Krimpenfort P, Corsini A, Rochette J, Glineur C, Fruchart JC, Torpier G, Staels B
J Clin Invest. 2005
PubMed ID: 16239970
Aberrant expression of tumor suppressor genes and their association with chimeric oncogenes in pediatric acute lymphoblastic leukemia.
Kustanovich AM, Savitskaja TV, Bydanov OI, Belevtsev MV, Potapnev MP
Leuk Res. 2005
PubMed ID: 15878620
Lifetime risk of melanoma in CDKN2A mutation carriers in a population-based sample.
Begg CB, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Mitra N, Busam K, From L, Berwick M, Genes Environment and Melanoma Study Group
J Natl Cancer Inst. 2005
PubMed ID: 16234564
Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).
Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD
Biochemistry. 2005
PubMed ID: 16201750
The Arf tumor suppressor regulates platelet-derived growth factor receptor beta signaling: a new view through the eyes of Arf(-/-) mice.
Thornton JD, Silva RL, Martin AC, Skapek SX
Cell Cycle. 2005
PubMed ID: 16205116
Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.
Fang MZ, Chen D, Sun Y, Jin Z, Christman JK, Yang CS
Clin Cancer Res. 2005
PubMed ID: 16203797
Nucleophosmin is required for DNA integrity and p19Arf protein stability.
Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG
Mol Cell Biol. 2005
PubMed ID: 16199867
Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event.
Lim KP, Sharifah H, Lau SH, Teo SH, Cheong SC
Oncol Rep. 2005
PubMed ID: 16142358
A common variant of CDKN2A (p16) predisposes to breast cancer.
Debniak T, Górski B, Huzarski T, Byrski T, Cybulski C, Mackiewicz A, Gozdecka-Grodecka S, Gronwald J, Kowalska E, Haus O, Grzybowska E, Stawicka M, Swiec M, Urbański K, Niepsuj S, Waśko B, Góźdź S, Wandzel P, Szczylik C, Surdyka D, Rozmiarek A, Zambrano O, Posmyk M, Narod SA, Lubinski J
J Med Genet. 2005
PubMed ID: 15879498
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ, Chen J
EMBO J. 2005
PubMed ID: 16107876
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R
Cancer Res. 2005
PubMed ID: 16166309
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.
Datta A, Sen J, Hagen J, Korgaonkar CK, Caffrey M, Quelle DE, Hughes DE, Ackerson TJ, Costa RH, Raychaudhuri P
Mol Cell Biol. 2005
PubMed ID: 16135794
Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.
Darbro BW, Schneider GB, Klingelhutz AJ
J Invest Dermatol. 2005
PubMed ID: 16117791
Examination of the pRb-dependent and pRb-independent functions of E7 in vivo.
Balsitis S, Dick F, Lee D, Farrell L, Hyde RK, Griep AE, Dyson N, Lambert PF
J Virol. 2005
PubMed ID: 16103190
ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress.
Pauklin S, Kristjuhan A, Maimets T, Jaks V
Biochem Biophys Res Commun. 2005
PubMed ID: 16004968
CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.
Bernard D, Martinez-Leal JF, Rizzo S, Martinez D, Hudson D, Visakorpi T, Peters G, Carnero A, Beach D, Gil J
Oncogene. 2005
PubMed ID: 15897876
INK4a/ARF: a multifunctional tumor suppressor locus.
Sharpless NE
Mutat Res. 2005
PubMed ID: 15878778
Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype.
Chapman EJ, Harnden P, Chambers P, Johnston C, Knowles MA
Clin Cancer Res. 2005
PubMed ID: 16115911
Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye.
Silva RL, Thornton JD, Martin AC, Rehg JE, Bertwistle D, Zindy F, Skapek SX
EMBO J. 2005
PubMed ID: 16037818
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Tolleson WH, Doss JC, Latendresse J, Warbritton AR, Melchior WB, Chin L, Dubielzig RR, Albert DM
Arch Ophthalmol. 2005
PubMed ID: 16087843
The fibroblast growth factor-2 is not essential for melanoma formation in a transgenic mouse model.
Ackermann J, Beermann F
Pigment Cell Res. 2005
PubMed ID: 16029424
The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity.
Choi BY, Choi HS, Ko K, Cho YY, Zhu F, Kang BS, Ermakova SP, Ma WY, Bode AM, Dong Z
Nat Struct Mol Biol. 2005
PubMed ID: 16007099
Human papillomavirus genotyping by oligonucleotide microarray and p16 expression in uterine cervical intraepithelial neoplasm and in invasive carcinoma in Korean women.
Lin ZH, Shen XH, Jin Z, Kim Y, Lee E, Kim H, Kim I
Pathol Int. 2005
PubMed ID: 15998377
A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress.
Stepanova L, Sorrentino BP
Blood. 2005
PubMed ID: 15692066
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.
Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA
Nature. 2005
PubMed ID: 16015333
Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations.
Becker TM, Rizos H, de la Pena A, Leclercq IA, Woodruff S, Kefford RF, Mann GJ
Biochem Biophys Res Commun. 2005
PubMed ID: 15913553
Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.
Yuan X, Zhou Y, Casanova E, Chai M, Kiss E, Gröne HJ, Schütz G, Grummt I
Mol Cell. 2005
PubMed ID: 15989966
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
Chen D, Kon N, Li M, Zhang W, Qin J, Gu W
Cell. 2005
PubMed ID: 15989956
Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion.
Hustinx SR, Leoni LM, Yeo CJ, Brown PN, Goggins M, Kern SE, Hruban RH, Maitra A
Mod Pathol. 2005
PubMed ID: 15832197
A mutation hotspot at the p14ARF splice site.
Harland M, Taylor CF, Chambers PA, Kukalizch K, Randerson-Moor JA, Gruis NA, de Snoo FA, ter Huurne JA, Goldstein AM, Tucker MA, Bishop DT, Bishop JA
Oncogene. 2005
PubMed ID: 15856016
Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo.
Helmrich A, Lee S, O'Brien P, Dörken B, Lowe SW, Schröck E, Schmitt CA
Oncogene. 2005
PubMed ID: 15824738
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.
Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M
Genes Dev. 2005
PubMed ID: 15964995
Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways.
Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R
Genes Dev. 2005
PubMed ID: 15964994
Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk.
Schulmann K, Sterian A, Berki A, Yin J, Sato F, Xu Y, Olaru A, Wang S, Mori Y, Deacu E, Hamilton J, Kan T, Krasna MJ, Beer DG, Pepe MS, Abraham JM, Feng Z, Schmiegel W, Greenwald BD, Meltzer SJ
Oncogene. 2005
PubMed ID: 15824739
Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells.
Hemmati PG, Normand G, Verdoodt B, von Haefen C, Hasenjäger A, Güner D, Wendt J, Dörken B, Daniel PT
Oncogene. 2005
PubMed ID: 15750619
p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue.
Kwong RA, Kalish LH, Nguyen TV, Kench JG, Bova RJ, Cole IE, Musgrove EA, Sutherland RL
Clin Cancer Res. 2005
PubMed ID: 15930346
[Immunocytochemistry (p16INK4a) as an additional examination for cytological specimens Class III D (Munich Classification II)]
Ziemke P
Zentralbl Gynakol. 2005
PubMed ID: 15915391
Hematopoietic malignancies associated with increased Stat5 and Bcl-x(L) expressions in Ink4a/Arf-deficient mice.
Sung YH, Park J, Choi B, Kim J, Cheong C, Choi YS, Yang EY, Lee M, Han JS, Park SC, Han TH, Kim TJ, Song J, Rhee K, Lee HW
Mech Ageing Dev. 2005
PubMed ID: 15888328
Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney.
Melk A, Schmidt BM, Vongwiwatana A, Rayner DC, Halloran PF
Am J Transplant. 2005
PubMed ID: 15888044
G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression.
Ausserlechner MJ, Obexer P, Geley S, Kofler R
Leukemia. 2005
PubMed ID: 15800668
The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions.
Lin Z, Gao M, Zhang X, Kim YS, Lee ES, Kim HK, Kim I
J Cancer Res Clin Oncol. 2005
PubMed ID: 15785933
Inhibition of human lens epithelial B-3 cell proliferation by adenovirus-mediated transfer of antisense c-myc construct.
Sun J, Xie L, Wang Y, Liu T
Graefes Arch Clin Exp Ophthalmol. 2005
PubMed ID: 15672251
Sumoylation induced by the Arf tumor suppressor: a p53-independent function.
Tago K, Chiocca S, Sherr CJ
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15897463
Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells.
Rotolo S, Diotti R, Gordon RE, Qiao RF, Yao Z, Phelps RG, Dong J
Int J Cancer. 2005
PubMed ID: 15657897
Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background.
Ackermann J, Frutschi M, Kaloulis K, McKee T, Trumpp A, Beermann F
Cancer Res. 2005
PubMed ID: 15899789
Mutation and homozygous deletion analyses of genes that control the G1/S transition of the cell cycle in skin melanoma: p53, p21, p16 and p15.
Soto Martínez JL, Cabrera Morales CM, Serrano Ortega S, López-Nevot MA
Clin Transl Oncol. 2005
PubMed ID: 15960923
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA
Cancer Cell. 2005
PubMed ID: 15894267
Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.
Nilsson JA, Keller UB, Baudino TA, Yang C, Norton S, Old JA, Nilsson LM, Neale G, Kramer DL, Porter CW, Cleveland JL
Cancer Cell. 2005
PubMed ID: 15894264
Role of epidermal growth factor receptor signaling in RAS-driven melanoma.
Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L
Mol Cell Biol. 2005
PubMed ID: 15870287
Role of the CDKN2A locus in patients with multiple primary melanomas.
Puig S, Malvehy J, Badenas C, Ruiz A, Jimenez D, Cuellar F, Azon A, Gonzàlez U, Castel T, Campoy A, Herrero J, Martí R, Brunet-Vidal J, Milà M
J Clin Oncol. 2005
PubMed ID: 15860862
Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders.
Kawamata N, Inagaki N, Mizumura S, Sugimoto KJ, Sakajiri S, Ohyanagi-Hara M, Oshimi K
Eur J Haematol. 2005
PubMed ID: 15813917
Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues.
Kim BN, Yamamoto H, Ikeda K, Damdinsuren B, Sugita Y, Ngan CY, Fujie Y, Ogawa M, Hata T, Ikeda M, Ohue M, Sekimoto M, Monden T, Matsuura N, Monden M
Int J Oncol. 2005
PubMed ID: 15809712
p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia.
Wang JL, Zheng BY, Li XD, Nokelainen K, Angström T, Lindström MS, Wallin KL
Mod Pathol. 2005
PubMed ID: 15502810
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Wang Y, Zhang Z, Lubet R, You M
Oncogene. 2005
PubMed ID: 15846305
Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16.
Kuroda H, Moritake H, Sawada K, Kuwahara Y, Imoto I, Inazawa J, Sugimoto T
Cancer Genet Cytogenet. 2005
PubMed ID: 15796965
Expression of p16INK4A variants in senescent human fibroblasts independent of protein phosphorylation.
Weebadda WK, Jackson TJ, Lin AW
J Cell Biochem. 2005
PubMed ID: 15668906
Direct interaction and cooperative role of tumor suppressor p16 with band 3 (AE1).
Fu GH, Wang Y, Xi YH, Shen WW, Pan XY, Shen WZ, Jiang XS, Chen GQ
FEBS Lett. 2005
PubMed ID: 15811326
In vitro and in vivo analysis of the interaction between 5.8S rRNA and ARF protein reveal a new difference between murine p19ARF and human p14ARF.
Andrique L, Ayrault O, Larsen CJ, Séité P
Oncogene. 2005
PubMed ID: 15735732
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Hu X, Pandolfi PP, Li Y, Koutcher JA, Rosenblum M, Holland EC
Neoplasia. 2005
PubMed ID: 15967113
p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the sumoylation of its binding partners.
Rizos H, Woodruff S, Kefford RF
Cell Cycle. 2005
PubMed ID: 15876874
Genotyping of patients with sporadic and radiation-associated meningiomas.
Sadetzki S, Flint-Richter P, Starinsky S, Novikov I, Lerman Y, Goldman B, Friedman E
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 15824172
AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene.
Ameyar-Zazoua M, Wisniewska MB, Bakiri L, Wagner EF, Yaniv M, Weitzman JB
Oncogene. 2005
PubMed ID: 15688012
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G
Oncogene. 2005
PubMed ID: 15735755
Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor.
Rocha S, Garrett MD, Campbell KJ, Schumm K, Perkins ND
EMBO J. 2005
PubMed ID: 15775976
Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.
Racanicchi S, Maccherani C, Liberatore C, Billi M, Gelmetti V, Panigada M, Rizzo G, Nervi C, Grignani F
EMBO J. 2005
PubMed ID: 15729358
Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.
Uhrbom L, Kastemar M, Johansson FK, Westermark B, Holland EC
Cancer Res. 2005
PubMed ID: 15781613
Genotype phenotype correlations in Israeli colorectal cancer patients.
Starinsky S, Figer A, Ben-Asher E, Geva R, Flex D, Fidder HH, Zidan J, Lancet D, Friedman E
Int J Cancer. 2005
PubMed ID: 15523694
Coexistence of copy number changes of different genes (INK4A, erbB-1, erbB-2, CMYC, CCND1 and ZNF217) in urothelial tumors.
Toncheva D, Zaharieva B
Tumour Biol. 2005
PubMed ID: 15897688
[The p16 methylation in oral leukoplakia and oral squamous cell carcinoma]
Liu HW, Hu BQ, Cao CF
Zhonghua Kou Qiang Yi Xue Za Zhi. 2005
PubMed ID: 15842853
Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes.
Bengtsson T, Aszodi A, Nicolae C, Hunziker EB, Lundgren-Akerlund E, Fässler R
J Cell Sci. 2005
PubMed ID: 15713743
Spectral karyotyping of sarcomas and fibroblasts derived from Ink4a/Arf-deficient mice reveals chromosomal instability in vitro.
Robertson SA, Schoumans J, Looyenga BD, Yuhas JA, Zylstra CR, Koeman JM, Swiatek PJ, Teh BT, Williams BO
Int J Oncol. 2005
PubMed ID: 15703817
Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis.
Gallagher S, Kefford RF, Rizos H
Cell Cycle. 2005
PubMed ID: 15701968
p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity.
Normand G, Hemmati PG, Verdoodt B, von Haefen C, Wendt J, Güner D, May E, Dörken B, Daniel PT
J Biol Chem. 2005
PubMed ID: 15582998
Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma.
Ma HB, Hu HT, Di ZL, Wang ZR, Shi JS, Wang XJ, Li Y
World J Gastroenterol. 2005
PubMed ID: 15655836
Detection of p16 hypermethylation in gastric carcinomas using a seminested methylation-specific PCR.
Hou P, Ji MJ, Shen JY, He NY, Lu ZH
Biochem Genet. 2005
PubMed ID: 15859515
Expression of cell cycle-related proteins in developing and adult mouse hippocampus.
Schmetsdorf S, Gärtner U, Arendt T
Int J Dev Neurosci. 2005
PubMed ID: 15730892
A search for CDKN2A/p16INK4a mutations in melanocytic nevi from patients with melanoma and spouse controls by use of laser-captured microdissection.
Wang H, Presland RB, Piepkorn M
Arch Dermatol. 2005
PubMed ID: 15724013
CDKN2A common variants and their association with melanoma risk: a population-based study.
Debniak T, Scott RJ, Huzarski T, Byrski T, Rozmiarek A, Debniak B, Załuga E, Maleszka R, Kładny J, Górski B, Cybulski C, Gronwald J, Kurzawski G, Lubinski J
Cancer Res. 2005
PubMed ID: 15705881
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.
Maeda T, Hobbs RM, Merghoub T, Guernah I, Zelent A, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP
Nature. 2005
PubMed ID: 15662416
Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan.
Wu MF, Cheng YW, Lai JC, Hsu MC, Chen JT, Liu WS, Chiou MC, Chen CY, Lee H
Int J Cancer. 2005
PubMed ID: 15455389
Loss of p16 protein defines high-risk patients with gastrointestinal stromal tumors: a tissue microarray study.
Schneider-Stock R, Boltze C, Lasota J, Peters B, Corless CL, Ruemmele P, Terracciano L, Pross M, Insabato L, Di Vizio D, Iesalnieks I, Dirnhofer S, Hartmann A, Heinrich M, Miettinen M, Roessner A, Tornillo L
Clin Cancer Res. 2005
PubMed ID: 15701851
The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression.
Suzuki H, Kurita M, Mizumoto K, Moriyama M, Aiso S, Nishimoto I, Matsuoka M
Biochem Biophys Res Commun. 2005
PubMed ID: 15567177
MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A.
Loercher AE, Tank EM, Delston RB, Harbour JW
J Cell Biol. 2005
PubMed ID: 15623583
Ductal pancreatic cancer in humans and mice.
Tuveson DA, Hingorani SR
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869739
P53 gene mutation and expression of MDM2, P53, P16 protein and their relationship in human glioma.
Cui W, Wu R, Cao H, Gao J, Wang X, Ren Q
J Huazhong Univ Sci Technolog Med Sci. 2005
PubMed ID: 16696307
Analysis of p16INK4a and integrated HPV genomes as progression markers.
Vinokurova S, Wentzensen N, von Knebel Doeberitz M
Methods Mol Med. 2005
PubMed ID: 16350398
[Evaluation of level of expression of p16 (INK4a) in endocervical lesions of uterine cervix]
Popovska S, Betova T, Tomov S, Gorchev G, Dikov T
Akush Ginekol (Sofiia). 2005
PubMed ID: 16313047
Effects of exogenous wild-type P16 gene transfection on the expression of cell cycle-related proteins in bladder cancer cell line.
Li L, Yang T, Lian X
Cancer Invest. 2005
PubMed ID: 16100943
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.
Attri J, Srinivasan R, Majumdar S, Radotra BD, Wig J
BMC Gastroenterol. 2005
PubMed ID: 15985168
Activation of protein kinase C alpha is required for TPA-triggered ERK (MAPK) signaling and growth inhibition of human hepatoma cell HepG2.
Wen-Sheng W, Jun-Ming H
J Biomed Sci. 2005
PubMed ID: 15917995
A strategy to study tyrosinase transgenes in mouse melanocytes.
Lavado A, Matheu A, Serrano M, Montoliu L
BMC Cell Biol. 2005
PubMed ID: 15826307
Mutation analysis of genes that control the G1/S cell cycle in melanoma: TP53, CDKN1A, CDKN2A, and CDKN2B.
Soto JL, Cabrera CM, Serrano S, López-Nevot MA
BMC Cancer. 2005
PubMed ID: 15819981
Inactivation of imprinted genes induced by cellular stress and tumorigenesis.
Pantoja C, de Los Ríos L, Matheu A, Antequera F, Serrano M
Cancer Res. 2005
PubMed ID: 15665276
Primary malignant lymphoma of the brain: frequent abnormalities and inactivation of p14 tumor suppressor gene.
Zhang SJ, Endo S, Saito T, Kouno M, Kuroiwa T, Washiyama K, Kumanishi T
Cancer Sci. 2005
PubMed ID: 15649253
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.
Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K
Mol Cell Biol. 2005
PubMed ID: 15601844
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
Raschke S, Balz V, Efferth T, Schulz WA, Florl AR
Genes Chromosomes Cancer. 2005
PubMed ID: 15495191
Significant role for p16INK4a in p53-independent telomere-directed senescence.
Jacobs JJ, de Lange T
Curr Biol. 2004
PubMed ID: 15620660
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.
Iwama A, Oguro H, Negishi M, Kato Y, Morita Y, Tsukui H, Ema H, Kamijo T, Katoh-Fukui Y, Koseki H, van Lohuizen M, Nakauchi H
Immunity. 2004
PubMed ID: 15589172
Early onset may predict G101W CDKN2A founder mutation carrier status in Ligurian melanoma patients.
Mantelli M, Pastorino L, Ghiorzo P, Barile M, Bruno W, Gargiulo S, Sormani MP, Gliori S, Vecchio S, Ciotti P, Sertoli MR, Queirolo P, Goldstein AM, Bianchi-Scarrà G, Italian Melanoma Intergroup
Melanoma Res. 2004
PubMed ID: 15577313
Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF.
Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Rünger TM
J Natl Cancer Inst. 2004
PubMed ID: 15572761
Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas.
Bachmann IM, Straume O, Akslen LA
Int J Oncol. 2004
PubMed ID: 15547691
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.
Woods YL, Xirodimas DP, Prescott AR, Sparks A, Lane DP, Saville MK
J Biol Chem. 2004
PubMed ID: 15355988
Loss of one allele of ARF rescues Mdm2 haploinsufficiency effects on apoptosis and lymphoma development.
Eischen CM, Alt JR, Wang P
Oncogene. 2004
PubMed ID: 15467748
p16INK4A hypermethylation is associated with hepatitis virus infection, age, and gender in hepatocellular carcinoma.
Li X, Hui AM, Sun L, Hasegawa K, Torzilli G, Minagawa M, Takayama T, Makuuchi M
Clin Cancer Res. 2004
PubMed ID: 15569978
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.
Matheu A, Pantoja C, Efeyan A, Criado LM, Martín-Caballero J, Flores JM, Klatt P, Serrano M
Genes Dev. 2004
PubMed ID: 15520276
Ink4a/Arf expression is a biomarker of aging.
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE
J Clin Invest. 2004
PubMed ID: 15520862
Alteration of the MDM2-p73-P14ARF pathway related to tumour progression during urinary bladder carcinogenesis.
Schlott T, Quentin T, Korabiowska M, Budd B, Kunze E
Int J Mol Med. 2004
PubMed ID: 15492852
p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer.
McCloud JM, Sivakumar R, Greenhough A, Elder J, Jones PW, Deakin M, Elder JB, Fryer AA, Hoban PR
Int J Oncol. 2004
PubMed ID: 15492837
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.
Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR
Genes Dev. 2004
PubMed ID: 15489287
ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway.
Brady SN, Yu Y, Maggi LB, Weber JD
Mol Cell Biol. 2004
PubMed ID: 15485902
Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells.
Lorincz MC, Dickerson DR, Schmitt M, Groudine M
Nat Struct Mol Biol. 2004
PubMed ID: 15467727
Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice.
Martín-Caballero J, Flores JM, García-Palencia P, Collado M, Serrano M
Oncogene. 2004
PubMed ID: 15378017
Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.
Ayrault O, Andrique L, Larsen CJ, Seite P
Oncogene. 2004
PubMed ID: 15361825
Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization.
Taylor LM, James A, Schuller CE, Brce J, Lock RB, Mackenzie KL
J Biol Chem. 2004
PubMed ID: 15308640
Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice.
Coré N, Joly F, Boned A, Djabali M
Oncogene. 2004
PubMed ID: 15377996
p19ARF directly and differentially controls the functions of c-Myc independently of p53.
Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR
Nature. 2004
PubMed ID: 15361884
Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas.
Garcia V, Silva J, Dominguez G, García JM, Peña C, Rodriguez R, Provencio M, España P, Bonilla F
Mutat Res. 2004
PubMed ID: 15450420
Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma.
Cui X, Shirai Y, Wakai T, Yokoyama N, Hirano S, Hatakeyama K
Hum Pathol. 2004
PubMed ID: 15492985
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.
Harrelson Z, Kelly RG, Goldin SN, Gibson-Brown JJ, Bollag RJ, Silver LM, Papaioannou VE
Development. 2004
PubMed ID: 15459098
Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene.
Martin AC, Thornton JD, Liu J, Wang X, Zuo J, Jablonski MM, Chaum E, Zindy F, Skapek SX
Invest Ophthalmol Vis Sci. 2004
PubMed ID: 15452040
p16(INK4A) expression is related to grade of cin and high-risk human papillomavirus but does not predict virus clearance after conization or disease outcome.
Branca M, Ciotti M, Santini D, Di Bonito L, Giorgi C, Benedetto A, Paba P, Favalli C, Costa S, Agarossi A, Alderisio M, Syrjänen K
Int J Gynecol Pathol. 2004
PubMed ID: 15381905
Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma.
Arbiser JL, Fan CY, Su X, Van Emburgh BO, Cerimele F, Miller MS, Harvell J, Marinkovich MP
J Invest Dermatol. 2004
PubMed ID: 15373786
p14ARF, p15INK4b and p16INK4a methylation status in chronic myelogenous leukemia.
Kusy S, Larsen CJ, Roche J
Leuk Lymphoma. 2004
PubMed ID: 15370242
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S
Pancreas. 2004
PubMed ID: 15367885
The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue.
Ben-Saadon R, Fajerman I, Ziv T, Hellman U, Schwartz AL, Ciechanover A
J Biol Chem. 2004
PubMed ID: 15254040
Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
Kastanos E, Hjiantoniou E, Phylactou LA
Biochem Biophys Res Commun. 2004
PubMed ID: 15336553
ATM activity contributes to the tumor-suppressing functions of p14ARF.
Li Y, Wu D, Chen B, Ingram A, He L, Liu L, Zhu D, Kapoor A, Tang D
Oncogene. 2004
PubMed ID: 15258567
Value of p16INK4a and RASSF1A promoter hypermethylation in prognosis of patients with resectable non-small cell lung cancer.
Wang J, Lee JJ, Wang L, Liu DD, Lu C, Fan YH, Hong WK, Mao L
Clin Cancer Res. 2004
PubMed ID: 15447998
Upregulation of p16(INK4A) and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours.
Yoshida T, Matsumoto N, Mikami T, Okayasu I
Br J Cancer. 2004
PubMed ID: 15292938
INK4a/Arf is required for suppression of EGFR/DeltaEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma.
Lachat Y, Diserens AC, Nozaki M, Kobayashi H, Hamou MF, Godard S, De Tribolet N, Hegi ME
Oncogene. 2004
PubMed ID: 15273738
Longitudinal assessment of the nevus phenotype in a melanoma kindred.
Florell SR, Meyer LJ, Boucher KM, Porter-Gill PA, Hart M, Erickson J, Cannon-Albright LA, Pershing LK, Harris RM, Samlowski WE, Zone JJ, Leachman SA
J Invest Dermatol. 2004
PubMed ID: 15304099
The INK4a /ARF locus: role in cell cycle control for renal cell epithelial tumor growth after the Chernobyl accident.
Romanenko A, Morell-Quadreny L, Lopez-Guerrero JA, Pellin A, Nepomnyaschy V, Vozianov A, Llombart-Bosch A
Virchows Arch. 2004
PubMed ID: 15232742
Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.
Datta A, Nag A, Pan W, Hay N, Gartel AL, Colamonici O, Mori Y, Raychaudhuri P
J Biol Chem. 2004
PubMed ID: 15199070
Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells.
Carstens MJ, Krempler A, Triplett AA, Van Lohuizen M, Wagner KU
J Biol Chem. 2004
PubMed ID: 15210712
Stability of nucleolar versus non-nucleolar forms of human p14(ARF).
Rodway H, Llanos S, Rowe J, Peters G
Oncogene. 2004
PubMed ID: 15286709
p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts.
Khan S, Guevara C, Fujii G, Parry D
Oncogene. 2004
PubMed ID: 15195142
Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging.
Johansson FK, Brodd J, Eklöf C, Ferletta M, Hesselager G, Tiger CF, Uhrbom L, Westermark B
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15273287
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways.
Kelly-Spratt KS, Gurley KE, Yasui Y, Kemp CJ
PLoS Biol. 2004
PubMed ID: 15314658
p16INK4A expression in malignant melanomas with or without a contiguous naevus remnant: a clue to their divergent pathogenesis?
Winnepenninckx V, van den Oord JJ
Melanoma Res. 2004
PubMed ID: 15305164
Germline CDKN2A mutations are rare in child and adolescent cutaneous melanoma.
Berg P, Wennberg AM, Tuominen R, Sander B, Rozell BL, Platz A, Hansson J
Melanoma Res. 2004
PubMed ID: 15305154
Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression.
Ghiorzo P, Mantelli M, Gargiulo S, Gramigni C, Pastorino L, Banelli B, Villaggio B, Coccia MC, Sementa AR, Garrè C, Bianchi-Scarrà G
Hum Pathol. 2004
PubMed ID: 15297971
Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study.
Sun Y, Deng D, You WC, Bai H, Zhang L, Zhou J, Shen L, Ma JL, Xie YQ, Li JY
Clin Cancer Res. 2004
PubMed ID: 15297411
Immunohistochemical analysis of thymidylate synthase, p16(INK4a), cyclin-dependent kinase 4 and cyclin D1 in colorectal cancers receiving preoperative chemotherapy: significance of p16(INK4a)-mediated cellular arrest as an indicator of chemosensitivity to
Kamoshida S, Matsuoka H, Shiogama K, Matsuyama A, Shimomura R, Inada K, Maruta M, Tsutsumi Y
Pathol Int. 2004
PubMed ID: 15260847
Hypermethylation of E-cadherin gene is frequent and independent of p16INK4A methylation in non-small cell lung cancer: potential prognostic implication.
Shimamoto T, Ohyashiki JH, Hirano T, Kato H, Ohyashiki K
Oncol Rep. 2004
PubMed ID: 15254707
Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast.
Zheng W, Wang H, Xue L, Zhang Z, Tong T
J Biol Chem. 2004
PubMed ID: 15138269
Self-assembling protein microarrays.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J
Science. 2004
PubMed ID: 15232106
Usefulness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Talar-Wojnarowska R, Gasiorowska A, Smolarz B, Romanowicz-Makowska H, Strzelczyk J, Janiak A, Kulig A, Malecka-Panas E
J Physiol Pharmacol. 2004
PubMed ID: 15608367
Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status.
Le Frère-Belda MA, Gil Diez de Medina S, Daher A, Martin N, Albaud B, Heudes D, Abbou CC, Thiery JP, Zafrani ES, Radvanyi F, Chopin D
Hum Pathol. 2004
PubMed ID: 15257544
Genetic loci that control the angiogenic response to basic fibroblast growth factor.
Rogers MS, Rohan RM, Birsner AE, D'Amato RJ
FASEB J. 2004
PubMed ID: 15226265
High frequency methylation of p16INK4A gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Nakahara Y, Shintani S, Mihara M, Matsumura T, Hamakawa H
Oncol Rep. 2004
PubMed ID: 15201967
Germline mutation and large deletion analysis of the CDKN2A and ARF genes in families with multiple melanoma or an aggregation of malignant melanoma and breast cancer.
Debniak T, Górski B, Scott RJ, Cybulski C, Medrek K, Zowocka E, Kurzawski G, Debniak B, Kadny J, Bielecka-Grzela S, Maleszka R, Lubiński J
Int J Cancer. 2004
PubMed ID: 15122588
Yin Yang 1 is a negative regulator of p53.
Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, Donohoe M, Luke MP, Calvo D, Grossman SR, Shi Y
Cell. 2004
PubMed ID: 15210108
p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Magro PG, Russo AJ, Li WW, Banerjee D, Bertino JR
Cancer Res. 2004
PubMed ID: 15205349
Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics.
Aslanian A, Iaquinta PJ, Verona R, Lees JA
Genes Dev. 2004
PubMed ID: 15175242
Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, Lisanti MP
J Biol Chem. 2004
PubMed ID: 15044451
[Investigations to the influence of tumor supressor gene p16 inactivation on the prognosis of head and neck squamous cell carcinoma]
Koscielny S, V Eggeling F, Dahse R
Laryngorhinootologie. 2004
PubMed ID: 15197677
Familial melanoma, pancreatic cancer and germline CDKN2A mutations.
Goldstein AM
Hum Mutat. 2004
PubMed ID: 15146471
DNA sequence and analysis of human chromosome 9.
Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blöcker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I
Nature. 2004
PubMed ID: 15164053
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM
Mol Cell. 2004
PubMed ID: 15149599
Influence of genes, nevi, and sun sensitivity on melanoma risk in a family sample unselected by family history and in melanoma-prone families.
Chaudru V, Chompret A, Bressac-de Paillerets B, Spatz A, Avril MF, Demenais F
J Natl Cancer Inst. 2004
PubMed ID: 15150307
Cancer chemopreventive activity of a mixture of Chinese herbs (antitumor B) in mouse lung tumor models.
Zhang Z, Wang Y, Yao R, Li J, Yan Y, La Regina M, Lemon WL, Grubbs CJ, Lubet RA, You M
Oncogene. 2004
PubMed ID: 15021904
p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma.
Brown VL, Harwood CA, Crook T, Cronin JG, Kelsell DP, Proby CM
J Invest Dermatol. 2004
PubMed ID: 15140233
Association of low p16INK4a and p15INK4b mRNAs expression with their CpG islands methylation with human hepatocellular carcinogenesis.
Qin Y, Liu JY, Li B, Sun ZL, Sun ZF
World J Gastroenterol. 2004
PubMed ID: 15112341
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.
Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA
Nat Cell Biol. 2004
PubMed ID: 15107860
p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development.
Yi Y, Shepard A, Kittrell F, Mulac-Jericevic B, Medina D, Said TK
Mol Biol Cell. 2004
PubMed ID: 15105443
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.
Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, Meeker A, Miao D, Huso DL, Arceci RJ
Genes Dev. 2004
PubMed ID: 15105378
Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in HeLa cells.
Xue L, Wu J, Zheng W, Wang P, Li J, Zhang Z, Tong T
FEBS Lett. 2004
PubMed ID: 15094066
Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer.
Sasiadek MM, Stembalska-Kozlowska A, Smigiel R, Ramsey D, Kayademir T, Blin N
Br J Cancer. 2004
PubMed ID: 15083191
Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.
Noble JR, Zhong ZH, Neumann AA, Melki JR, Clark SJ, Reddel RR
Oncogene. 2004
PubMed ID: 14743210
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner.
Li J, Melvin WS, Tsai MD, Muscarella P
Biochemistry. 2004
PubMed ID: 15065884
Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer.
Wang JL, Zheng BY, Li XD, Angström T, Lindström MS, Wallin KL
Clin Cancer Res. 2004
PubMed ID: 15073118
INK4a-ARF mutations in skin carcinomas from UV irradiated hairless mice.
Soufir N, Queille S, Mollier K, Roux E, Sarasin A, de Gruijl FR, Fourtanier AM, Daya-Grosjean L, Basset-Seguin N
Mol Carcinog. 2004
PubMed ID: 15057871
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis.
Sachs Z, Sharpless NE, DePinho RA, Rosenberg N
J Virol. 2004
PubMed ID: 15016851
p16INK4A gene alterations are not a prognostic indicator for survival in patients with hepatocellular carcinoma undergoing curative hepatectomy.
Anzola M, Cuevas N, Lopez-Martinez M, Martinez de Pancorbo M, Burgos JJ
J Gastroenterol Hepatol. 2004
PubMed ID: 15012776
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway.
Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, Anderson CW, Appella E, Fornace AJ
Nat Genet. 2004
PubMed ID: 14991053
[p16 protein expression in the transplacental induced brain tumor in rat]
Zhang ZY, Zhang YF
Zhonghua Wai Ke Za Zhi. 2004
PubMed ID: 15144691
Molecular pathology shows p16 methylation in nonadenomatous pituitaries from patients with Cushing's disease.
Simpson DJ, McNicol AM, Murray DC, Bahar A, Turner HE, Wass JA, Esiri MM, Clayton RN, Farrell WE
Clin Cancer Res. 2004
PubMed ID: 15014032
Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China.
Ueki T, Hsing AW, Gao YT, Wang BS, Shen MC, Cheng J, Deng J, Fraumeni JF, Rashid A
Clin Cancer Res. 2004
PubMed ID: 15014024
Inactivation of the cyclin-dependent kinase inhibitor 2A (CDKN2A) gene in squamous cell carcinoma of the larynx.
Smigiel R, Sasiadek M, Krecicki T, Ramsey D, Jagielski J, Blin N
Mol Carcinog. 2004
PubMed ID: 14991744
Extending the p16-Leiden tumour spectrum by respiratory tract tumours.
Oldenburg RA, de Vos tot Nederveen Cappel WH, van Puijenbroek M, van den Ouweland A, Bakker E, Griffioen G, Devilee P, Cornelisse CJ, Meijers-Heijboer H, Vasen HF, Morreau H
J Med Genet. 2004
PubMed ID: 14985402
The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer.
Yang C, Ionescu-Tiba V, Burns K, Gadd M, Zukerberg L, Louis DN, Sgroi D, Schmidt EV
Am J Pathol. 2004
PubMed ID: 14982856
Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway.
Shamanin VA, Androphy EJ
Mol Cell Biol. 2004
PubMed ID: 14966292
High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population.
Hu N, Wang C, Su H, Li WJ, Emmert-Buck MR, Li G, Roth MJ, Tang ZZ, Lu N, Giffen C, Albert PS, Taylor PR, Goldstein AM
Genes Chromosomes Cancer. 2004
PubMed ID: 14732922
An Arf(GFP/GFP) reporter mouse reveals that the Arf tumor suppressor monitors latent oncogenic signals in vivo.
Sherr CJ
Cell Cycle. 2004
PubMed ID: 14726696
Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1.
Pollice A, Nasti V, Ronca R, Vivo M, Lo Iacono M, Calogero R, Calabrò V, La Mantia G
J Biol Chem. 2004
PubMed ID: 14665636
[Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]
Chen YX, Fang JY, Lu J, Qiu DK
Zhonghua Yi Xue Za Zhi. 2004
PubMed ID: 15059516
p16 expression in squamous lesions of the female genital tract.
Finegan MM, Han AC, Edelson MI, Rosenblum NG
J Mol Histol. 2004
PubMed ID: 15328914
Electron microscopy evidence that cytoplasmic localization of the p16(INK4A) "nuclear" cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas.
Evangelou K, Bramis J, Peros I, Zacharatos P, Dasiou-Plakida D, Kalogeropoulos N, Asimacopoulos PJ, Kittas C, Marinos E, Gorgoulis VG
Biotech Histochem. 2004
PubMed ID: 15223748
Estimating the relative risk of developing melanoma in INK4A carriers.
Berwick M, Orlow I, Mahabir S, Myskowski P, Coit D, Brady MS, Roy P, Song Y, Canchola R, Barz A, Halpern A, Bolognia J, Eng S, Elahi A, Begg CB
Eur J Cancer Prev. 2004
PubMed ID: 15075790
Chronic HIV type 1 infection down-regulates expression of DAP kinase and p19ARF-p53 checkpoint and is associated with resistance to CD95-mediated apoptosis in HUT78 T cells.
Kim CH, Chiplunkar S, Gupta S
AIDS Res Hum Retroviruses. 2004
PubMed ID: 15018706
Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53.
Scott LA, Vass JK, Parkinson EK, Gillespie DA, Winnie JN, Ozanne BW
Mol Cell Biol. 2004
PubMed ID: 14749371
Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: clinical implications.
González-Quevedo R, García-Aranda C, Morán A, De Juan C, Sánchez-Pernaute A, Torres A, Díaz-Rubio E, Balibrea JL, Benito M, Iniesta P
Int J Oncol. 2004
PubMed ID: 14719111
Deletion in p16INK4a and loss of p16 expression in human skin primary and metastatic melanoma cells.
Zhang H, Rosdahl I
Int J Oncol. 2004
PubMed ID: 14719109
Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer.
Paradiso A, Ranieri G, Stea B, Zito A, Zehbe I, Tommasino M, Grammatica L, De Lena M
Int J Oncol. 2004
PubMed ID: 14719099
Expression of p16INK4a and other cell cycle regulator and senescence associated genes in aging human kidney.
Melk A, Schmidt BM, Takeuchi O, Sawitzki B, Rayner DC, Halloran PF
Kidney Int. 2004
PubMed ID: 14717921
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells.
Oruetxebarria I, Venturini F, Kekarainen T, Houweling A, Zuijderduijn LM, Mohd-Sarip A, Vries RG, Hoeben RC, Verrijzer CP
J Biol Chem. 2004
PubMed ID: 14604992
Germline mutations of the INK4a-ARF gene in patients with suspected genetic predisposition to melanoma.
Soufir N, Lacapere JJ, Bertrand G, Matichard E, Meziani R, Mirebeau D, Descamps V, Gérard B, Archimbaud A, Ollivaud L, Bouscarat F, Baccard M, Lanternier G, Saïag P, Lebbé C, Basset-Seguin N, Crickx B, Cave H, Grandchamp B
Br J Cancer. 2004
PubMed ID: 14735200
The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins.
Kim JH, Yoon SY, Kim CN, Joo JH, Moon SK, Choe IS, Choe YK, Kim JW
Cancer Lett. 2004
PubMed ID: 14732230
Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16(INK4a).
Faast R, White J, Cartwright P, Crocker L, Sarcevic B, Dalton S
Oncogene. 2004
PubMed ID: 14724578
The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.
Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA
Oncogene. 2004
PubMed ID: 14724566
BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study.
Casula M, Colombino M, Satta MP, Cossu A, Ascierto PA, Bianchi-Scarrà G, Castiglia D, Budroni M, Rozzo C, Manca A, Lissia A, Carboni A, Petretto E, Satriano SM, Botti G, Mantelli M, Ghiorzo P, Stratton MR, Tanda F, Palmieri G, Italian Melanoma Intergroup Study
J Clin Oncol. 2004
PubMed ID: 14722037
Analysis of P161NK4A protein expression in follicular thyroid tumors.
Ferenc T, Lewiński A, Lange D, Niewiadomska H, Sygut J, Sporny S, Jarzab B, Sałacińska-Loś E, Kulig A, Włoch J
Pol J Pathol. 2004
PubMed ID: 15757201
Loss of p16/CDKN2A protein in Epstein-Barr virus-associated gastric carcinoma.
Koriyama C, Kitajima S, Nomoto M, Sueyoshi K, Itoh T, Eizuru Y, Yonezawa S, Akiba S
Oncology. 2004
PubMed ID: 15459500
Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas.
Ito T, Nishida N, Fukuda Y, Nishimura T, Komeda T, Nakao K
J Gastroenterol. 2004
PubMed ID: 15168247
p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.
Xia L, Paik A, Li JJ
Cancer Res. 2004
PubMed ID: 14729628
Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation.
Bond J, Jones C, Haughton M, DeMicco C, Kipling D, Wynford-Thomas D
Exp Cell Res. 2004
PubMed ID: 14720514
INK4/ARF germline alterations in pancreatic cancer patients.
Ghiorzo P, Pastorino L, Bonelli L, Cusano R, Nicora A, Zupo S, Queirolo P, Sertoli M, Pugliese V, Bianchi-Scarrà G
Ann Oncol. 2004
PubMed ID: 14679123
Mdm2 regulates p53 independently of p19(ARF) in homeostatic tissues.
O'Leary KA, Mendrysa SM, Vaccaro A, Perry ME
Mol Cell Biol. 2004
PubMed ID: 14673154
p19ARF-induced p53-independent apoptosis largely occurs through BAX.
Suzuki H, Kurita M, Mizumoto K, Nishimoto I, Ogata E, Matsuoka M
Biochem Biophys Res Commun. 2003
PubMed ID: 14652011
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo.
Zindy F, Williams RT, Baudino TA, Rehg JE, Skapek SX, Cleveland JL, Roussel MF, Sherr CJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14665695
Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray.
Xie D, Sham JS, Zeng WF, Lin HL, Che LH, Wu HX, Wen JM, Fang Y, Hu L, Guan XY
Int J Cancer. 2003
PubMed ID: 14601048
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA
Genes Dev. 2003
PubMed ID: 14681207
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
Lewis BC, Klimstra DS, Varmus HE
Genes Dev. 2003
PubMed ID: 14681205
p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis.
Rosty C, Geradts J, Sato N, Wilentz RE, Roberts H, Sohn T, Cameron JL, Yeo CJ, Hruban RH, Goggins M
Am J Surg Pathol. 2003
PubMed ID: 14657708
A novel L94Q mutation in the CDKN2A gene in a melanoma kindred.
Avbelj M, Hocevar M, Trebusak-Podkrajsek K, Krzisnik C, Battelino T
Melanoma Res. 2003
PubMed ID: 14646619
Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway.
Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y
Mol Cell Biol. 2003
PubMed ID: 14612427
Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal squamous cell carcinomas.
Ibrahim SO, Lillehaug JR, Vasstrand EN
Anticancer Res. 2003
PubMed ID: 14981901
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.
Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y
Mol Cell. 2003
PubMed ID: 14636574
Differential alterations of the genes in the CDKN2A-CCND1-CDK4-RB1 pathway are associated with the development of head and neck squamous cell carcinoma in Indian patients.
Tripathi Bhar A, Banerjee S, Chunder N, Roy A, Sengupta A, Roy B, Roychowdhury S, Panda CK
J Cancer Res Clin Oncol. 2003
PubMed ID: 14586645
Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.
Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S
Mol Cell Biol. 2003
PubMed ID: 14560011
CDKN2A as a uveal and cutaneous melanoma susceptibility gene.
Kannengiesser C, Avril MF, Spatz A, Laud K, Lenoir GM, Bressac-de-Paillerets B
Genes Chromosomes Cancer. 2003
PubMed ID: 14506702
Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway.
Lee TK, Man K, Ling MT, Wang XH, Wong YC, Lo CM, Poon RT, Ng IO, Fan ST
Carcinogenesis. 2003
PubMed ID: 12949053
Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.
Moore L, Venkatachalam S, Vogel H, Watt JC, Wu CL, Steinman H, Jones SN, Donehower LA
Oncogene. 2003
PubMed ID: 14586409
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.
Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ
Nature. 2003
PubMed ID: 14574365
Aberrant p16 promoter methylation in smokers and former smokers with nonsmall cell lung cancer.
Jarmalaite S, Kannio A, Anttila S, Lazutka JR, Husgafvel-Pursiainen K
Int J Cancer. 2003
PubMed ID: 12918069
Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci.
Schreiner B, Greten FR, Baur DM, Fingerle AA, Zechner U, Böhm C, Schmid M, Hameister H, Schmid RM
Oncogene. 2003
PubMed ID: 14555993
Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes.
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heavens D, Marshall J, Fried M, Peters G
Cancer Cell. 2003
PubMed ID: 14585357
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
Aszodi A, Hunziker EB, Brakebusch C, Fässler R
Genes Dev. 2003
PubMed ID: 14522949
Differences in loss of p16INK4 protein expression by promoter methylation between left- and right-sided primary colorectal carcinomas.
Schneider-Stock R, Boltze C, Peters B, Höpfner T, Meyer F, Lippert H, Roessner A
Int J Oncol. 2003
PubMed ID: 12963980
Germline splicing mutations of CDKN2A predispose to melanoma.
Loo JC, Liu L, Hao A, Gao L, Agatep R, Shennan M, Summers A, Goldstein AM, Tucker MA, Deters C, Fusaro R, Blazer K, Weitzel J, Lassam N, Lynch H, Hogg D
Oncogene. 2003
PubMed ID: 14508519
p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors.
Perrone F, Tabano S, Colombo F, Dagrada G, Birindelli S, Gronchi A, Colecchia M, Pierotti MA, Pilotti S
Clin Cancer Res. 2003
PubMed ID: 14519636
Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma.
O'Hagan RC, Brennan CW, Strahs A, Zhang X, Kannan K, Donovan M, Cauwels C, Sharpless NE, Wong WH, Chin L
Cancer Res. 2003
PubMed ID: 14500367
Adenoviral p16/CDKN2 gene transfer to malignant glioma: role of p16 in growth, invasion, and senescence.
Kim SK, Wang KC, Cho BK, Lim SY, Kim YY, Oh CW, Chung YN, Kim CY, Lee CT, Kim HJ
Oncol Rep. 2003
PubMed ID: 12883667
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.
Sharpless NE, Kannan K, Xu J, Bosenberg MW, Chin L
Oncogene. 2003
PubMed ID: 12902988
Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1.
Smith KS, Chanda SK, Lingbeek M, Ross DT, Botstein D, van Lohuizen M, Cleary ML
Mol Cell. 2003
PubMed ID: 14536079
Alterations in CDKN2A locus as potential indicator of melanoma predisposition in relatives of non-familial melanoma cases.
Levanat S, Situm M, Crnić I, Marasović D, Puizina-Ivić N, Pokupcić N, Musani V, Komar A, Kubat M, Furac I, Karija-Vlahović M, Krizanac S
Croat Med J. 2003
PubMed ID: 12950144
Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice.
Wang Y, Zhang Z, Kastens E, Lubet RA, You M
Cancer Res. 2003
PubMed ID: 12907609
Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model.
Hesselager G, Uhrbom L, Westermark B, Nistér M
Cancer Res. 2003
PubMed ID: 12907595
Ocular melanoma is not associated with CDKN2A or MC1R variants--a population-based study.
Vajdic C, Kricker A, Duffy DL, Aitken JF, Stark M, ter Huurne JA, Martin NG, Armstrong BK, Hayward NK
Melanoma Res. 2003
PubMed ID: 12883368
Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.
Natarajan E, Saeb M, Crum CP, Woo SB, McKee PH, Rheinwald JG
Am J Pathol. 2003
PubMed ID: 12875969
Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer.
Chang LL, Yeh WT, Yang SY, Wu WJ, Huang CH
J Urol. 2003
PubMed ID: 12853838
ARF tumor suppressor induces mitochondria-dependent apoptosis by modulation of mitochondrial Bcl-2 family proteins.
Nakazawa Y, Kamijo T, Koike K, Noda T
J Biol Chem. 2003
PubMed ID: 12740365
Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5.
Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, Ghysdael J, Rowe M, Hara E
J Cell Biol. 2003
PubMed ID: 12860972
EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells.
Kashuba E, Mattsson K, Pokrovskaja K, Kiss C, Protopopova M, Ehlin-Henriksson B, Klein G, Szekely L
Int J Cancer. 2003
PubMed ID: 12740913
Alterations of the P16 gene in uterine cervical carcinoma from Indian patients.
Tripathi A, Banerjee S, Roy A, Roychowdhury S, Panda CK
Int J Gynecol Cancer. 2003
PubMed ID: 12911724
p16 immunoreactivity may assist in the distinction between endometrial and endocervical adenocarcinoma.
McCluggage WG, Jenkins D
Int J Gynecol Pathol. 2003
PubMed ID: 12819388
The latent membrane protein 1 of Epstein-Barr virus and loss of the INK4a locus: paradoxes resolve to cooperation in carcinogenesis in vivo.
Macdiarmid J, Stevenson D, Campbell DH, Wilson JB
Carcinogenesis. 2003
PubMed ID: 12807717
Hypermethylation of the CDKN2A gene in colorectal cancer is associated with shorter survival.
Maeda K, Kawakami K, Ishida Y, Ishiguro K, Omura K, Watanabe G
Oncol Rep. 2003
PubMed ID: 12792748
The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.
D'Amico M, Wu K, Di Vizio D, Reutens AT, Stahl M, Fu M, Albanese C, Russell RG, Muller WJ, White M, Negassa A, Lee HW, DePinho RA, Pestell RG
Cancer Res. 2003
PubMed ID: 12810676
Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations.
Eskandarpour M, Hashemi J, Kanter L, Ringborg U, Platz A, Hansson J
J Natl Cancer Inst. 2003
PubMed ID: 12783933
The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines.
Robinson WA, Miller TL, Harrold EA, Bemis LT, Brady BM, Nelson RP
Melanoma Res. 2003
PubMed ID: 12777976
Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.
Yakushiji T, Uzawa K, Shibahara T, Noma H, Tanzawa H
Int J Oncol. 2003
PubMed ID: 12738984
Oligomerization of the human ARF tumor suppressor and its response to oxidative stress.
Menéndez S, Khan Z, Coomber DW, Lane DP, Higgins M, Koufali MM, Lain S
J Biol Chem. 2003
PubMed ID: 12582152
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
Sviderskaya EV, Gray-Schopfer VC, Hill SP, Smit NP, Evans-Whipp TJ, Bond J, Hill L, Bataille V, Peters G, Kipling D, Wynford-Thomas D, Bennett DC
J Natl Cancer Inst. 2003
PubMed ID: 12759390
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF
Nature. 2003
PubMed ID: 12714971
The expression of cyclin-dependent kinase inhibitors p15, p16, p21, and p27 during ovarian follicle growth initiation in the mouse.
Bayrak A, Oktay K
Reprod Biol Endocrinol. 2003
PubMed ID: 12777178
Expression and characterization of Syrian golden hamster p16, a homologue of human tumor suppressor p16 INK4A.
Li J, Qin D, Knobloch TJ, Tsai MD, Weghorst CM, Melvin WS, Muscarella P
Biochem Biophys Res Commun. 2003
PubMed ID: 12711305
Detection of p16 promoter hypermethylation in serum of gastric cancer patients.
Kanyama Y, Hibi K, Nakayama H, Kodera Y, Ito K, Akiyama S, Nakao A
Cancer Sci. 2003
PubMed ID: 12824886
p16(INK4a) induces differentiation and apoptosis in erythroid lineage cells.
Minami R, Muta K, Umemura T, Motomura S, Abe Y, Nishimura J, Nawata H
Exp Hematol. 2003
PubMed ID: 12763133
Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease.
Klump B, Hsieh CJ, Dette S, Holzmann K, Kiebetalich R, Jung M, Sinn U, Ortner M, Porschen R, Gregor M
Clin Cancer Res. 2003
PubMed ID: 12738733
Relationship between inactivation of p16 gene and gastric carcinoma.
Zhao GH, Li TC, Shi LH, Xia YB, Lu LM, Huang WB, Sun HL, Zhang YS
World J Gastroenterol. 2003
PubMed ID: 12717828
Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer.
Yeh KT, Chang JG, Lin TH, Wang YF, Tien N, Chang JY, Chen JC, Shih MC
Oncol Rep. 2003
PubMed ID: 12684640
Alterations of p14ARF and p16INK4a genes in salivary gland carcinomas.
Nishimine M, Nakamura M, Kishi M, Okamoto M, Shimada K, Ishida E, Kirita T, Konishi N
Oncol Rep. 2003
PubMed ID: 12684623
Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells.
Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y, Kondo S
Br J Cancer. 2003
PubMed ID: 12698196
p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities.
Guo F, Gao Y, Wang L, Zheng Y
J Biol Chem. 2003
PubMed ID: 12578823
p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.
Zhang S, Qian X, Redman C, Bliskovski V, Ramsay ES, Lowy DR, Mock BA
Oncogene. 2003
PubMed ID: 12700664
Invade or proliferate? Two contrasting events in malignant behavior governed by p16(INK4a) and an intact Rb pathway illustrated by a model system of basal cell carcinoma.
Svensson S, Nilsson K, Ringberg A, Landberg G
Cancer Res. 2003
PubMed ID: 12702553
Delineation of the domains required for physical and functional interaction of p14ARF with human topoisomerase I.
Ayrault O, Olivier A, Karayan L, Lucie K, Riou JF, Jean-François R, Larsen CJ, Christian-Jacques L, Séité P, Paule S
Oncogene. 2003
PubMed ID: 12673200
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.
Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD
Cancer Res. 2003
PubMed ID: 12670910
Genetic determinants of malignancy in a mouse model for oligodendroglioma.
Weiss WA, Burns MJ, Hackett C, Aldape K, Hill JR, Kuriyama H, Kuriyama N, Milshteyn N, Roberts T, Wendland MF, DePinho R, Israel MA
Cancer Res. 2003
PubMed ID: 12670909
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts.
Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM
Mol Cell Biol. 2003
PubMed ID: 12665584
Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response.
Lyakhovich A, Shekhar MP
Mol Cell Biol. 2003
PubMed ID: 12640129
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice.
Eymin B, Leduc C, Coll JL, Brambilla E, Gazzeri S
Oncogene. 2003
PubMed ID: 12660818
Consistent inactivation of p19(Arf) but not p15(Ink4b) in murine myeloid cells transformed in vivo by deregulated c-Myc.
Haviernik P, Schmidt M, Hu X, Wolff L
Oncogene. 2003
PubMed ID: 12642863
Loss of p16INK4a results in increased glucocorticoid receptor activity during fibrosarcoma development.
Roca R, Kypta RM, Vivanco MM
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12624188
Design and characterization of a hyperstable p16INK4a that restores Cdk4 binding activity when combined with oncogenic mutations.
Cammett TJ, Luo L, Peng ZY
J Mol Biol. 2003
PubMed ID: 12614625
Clinical course of bladder neoplasms and single nucleotide polymorphisms in the CDKN2A gene.
Sakano S, Berggren P, Kumar R, Steineck G, Adolfsson J, Onelöv E, Hemminki K, Larsson P
Int J Cancer. 2003
PubMed ID: 12532425
Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.
Padilla PI, Chang MJ, Pacheco-Rodriguez G, Adamik R, Moss J, Vaughan M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12606707
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.
Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, van Lohuizen M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12589020
Studies on microsatellite instability in p16 gene and expression of hMSH2 mRNA in human gastric cancer tissues.
Zhang QX, Ding Y, Le XP, Du P
World J Gastroenterol. 2003
PubMed ID: 12632492
Methylation and mutation analysis of p16 gene in gastric cancer.
Ding Y, Le XP, Zhang QX, Du P
World J Gastroenterol. 2003
PubMed ID: 12632489
A novel putative collaborator of p19ARF.
Wadhwa R, Sugihara T, Hasan MK, Duncan EL, Taira K, Kaul SC
Exp Gerontol. 2003
PubMed ID: 12581788
Phosphorylation of p16INK4A correlates with Cdk4 association.
Gump J, Stokoe D, McCormick F
J Biol Chem. 2003
PubMed ID: 12529334
Multiple domains of the mouse p19ARF tumor suppressor are involved in p53-independent apoptosis.
Matsuoka M, Kurita M, Sudo H, Mizumoto K, Nishimoto I, Ogata E
Biochem Biophys Res Commun. 2003
PubMed ID: 12589812
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Wen-Sheng W
Oncogene. 2003
PubMed ID: 12592382
p16 Hypermethylation in the early stage of hepatitis B virus-associated hepatocarcinogenesis.
Shim YH, Yoon GS, Choi HJ, Chung YH, Yu E
Cancer Lett. 2003
PubMed ID: 12565176
Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus.
Gibson SL, Dai CY, Lee HW, DePinho RA, Gee MS, Lee WM, Furth EE, Brensinger C, Enders GH
Cancer Res. 2003
PubMed ID: 12591718
Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition.
Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF
J Biol Chem. 2003
PubMed ID: 12446718
p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Bai H, Gu L, Zhou J, Deng D
Mutat Res. 2003
PubMed ID: 12547284
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M, Chin L
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12538879
Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.
Sugimoto M, Kuo ML, Roussel MF, Sherr CJ
Mol Cell. 2003
PubMed ID: 12620229
Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.
Park MJ, Shimizu K, Nakano T, Park YB, Kohno T, Tani M, Yokota J
Cancer Genet Cytogenet. 2003
PubMed ID: 12581892
Contribution of germline mutations in BRCA2, P16(INK4A), P14(ARF) and P15 to uveal melanoma.
Hearle N, Damato BE, Humphreys J, Wixey J, Green H, Stone J, Easton DF, Houlston RS
Invest Ophthalmol Vis Sci. 2003
PubMed ID: 12556369
The mouse Ink4a/Arf locus: a p53 pile-up at a tumour surveillance crossroads?
Kelly RG
Trends Genet. 2003
PubMed ID: 12547516
Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions.
Klump B, Hsieh CJ, Nehls O, Dette S, Holzmann K, Kiesslich R, Jung M, Sinn U, Ortner M, Porschen R, Gregor M
Br J Cancer. 2003
PubMed ID: 12610506
Hypermethylation of the CDKN2/p16INK4A promotor in thyroid carcinogenesis.
Boltze C, Zack S, Quednow C, Bettge S, Roessner A, Schneider-Stock R
Pathol Res Pract. 2003
PubMed ID: 12924440
Genetic and epigenetic alterations of 9p21 gene products in benign and malignant tumors of the head and neck.
Weber A, Wittekind C, Tannapfel A
Pathol Res Pract. 2003
PubMed ID: 12924439
Conditional mouse models demonstrate oncogene-dependent differences in tumor maintenance and recurrence.
Tilli MT, Furth PA
Breast Cancer Res. 2003
PubMed ID: 12817992
Expression of p16 protein and hypermethylation status of its promoter gene in adenoid cystic carcinoma of the head and neck.
Maruya S, Kurotaki H, Shimoyama N, Kaimori M, Shinkawa H, Yagihashi S
ORL J Otorhinolaryngol Relat Spec. 2003
PubMed ID: 12624503
Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways.
Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE
Mol Cancer Res. 2003
PubMed ID: 12556559
Hereditary p16-Leiden mutation in a patient with multiple head and neck tumors.
Schneider-Stock R, Giers A, Motsch C, Boltze C, Evert M, Freigang B, Roessner A
Am J Hum Genet. 2003
PubMed ID: 12549483
Perturbations of the Ink4a/Arf gene locus in aflatoxin B1-induced mouse lung tumors.
Tam AS, Devereux TR, Patel AC, Foley JF, Maronpot RR, Massey TE
Carcinogenesis. 2003
PubMed ID: 12538357
Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes.
Chaturvedi V, Cesnjaj M, Bacon P, Panella J, Choubey D, Diaz MO, Nickoloff BJ
Am J Pathol. 2003
PubMed ID: 12507899
Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1.
Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP
Mol Cell Biol. 2003
PubMed ID: 12482990
ARF mutation accelerates pituitary tumor development in Rb+/- mice.
Tsai KY, MacPherson D, Rubinson DA, Nikitin AY, Bronson R, Mercer KL, Crowley D, Jacks T
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12486224
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
De novo methylation of the p16INK4A gene in early preneoplastic liver and tumors induced by folate/methyl deficiency in rats.
Pogribny IP, James SJ
Cancer Lett. 2002
PubMed ID: 12359353
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
CDKN2A promoter methylation in gastric adenocarcinomas: clinical variables.
Vo QN, Geradts J, Boudreau DA, Bravo JC, Schneider BG
Hum Pathol. 2002
PubMed ID: 12514789
Association of p16(INK4a) and pRb inactivation with immortalization of human cells.
Tsutsui T, Kumakura S, Yamamoto A, Kanai H, Tamura Y, Kato T, Anpo M, Tahara H, Barrett JC
Carcinogenesis. 2002
PubMed ID: 12507935
The CDKN2A tumour suppressor gene: no mutations detected in patients with melanoma and additional unrelated cancers.
Alao JP, Mohammed MQ, Retsas S
Melanoma Res. 2002
PubMed ID: 12459645
Clinical and histopathological features of malignant melanoma in germline CDKN2A mutation families.
Måsbäck A, Olsson H, Westerdahl J, Sandberg T, Borg A, Jonsson N, Ingvar C
Melanoma Res. 2002
PubMed ID: 12459644
Loss of p16 expression is associated with histological features of melanoma invasion.
Pavey SJ, Cummings MC, Whiteman DC, Castellano M, Walsh MD, Gabrielli BG, Green A, Hayward NK
Melanoma Res. 2002
PubMed ID: 12459643
CDKN2A germline mutations in familial pancreatic cancer.
Bartsch DK, Sina-Frey M, Lang S, Wild A, Gerdes B, Barth P, Kress R, Grützmann R, Colombo-Benkmann M, Ziegler A, Hahn SA, Rothmund M, Rieder H
Ann Surg. 2002
PubMed ID: 12454511
Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF.
Datta A, Nag A, Raychaudhuri P
Mol Cell Biol. 2002
PubMed ID: 12446760
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts.
Huot TJ, Rowe J, Harland M, Drayton S, Brookes S, Gooptu C, Purkis P, Fried M, Bataille V, Hara E, Newton-Bishop J, Peters G
Mol Cell Biol. 2002
PubMed ID: 12417717
Prevalent involvement of illegitimate V(D)J recombination in chromosome 9p21 deletions in lymphoid leukemia.
Kitagawa Y, Inoue K, Sasaki S, Hayashi Y, Matsuo Y, Lieber MR, Mizoguchi H, Yokota J, Kohno T
J Biol Chem. 2002
PubMed ID: 12228235
Ink4a/arf deficiency promotes ultraviolet radiation-induced melanomagenesis.
Recio JA, Noonan FP, Takayama H, Anver MR, Duray P, Rush WL, Lindner G, De Fabo EC, DePinho RA, Merlino G
Cancer Res. 2002
PubMed ID: 12438273
p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells.
Herbert BS, Wright WE, Shay JW
Oncogene. 2002
PubMed ID: 12420227
Immunohistochemical comparison of p16 expression in actinic keratoses and squamous cell carcinomas of the skin.
Hodges A, Smoller BR
Mod Pathol. 2002
PubMed ID: 12429789
Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1.
Benanti JA, Williams DK, Robinson KL, Ozer HL, Galloway DA
Mol Cell Biol. 2002
PubMed ID: 12370286
Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis.
Sharp R, Recio JA, Jhappan C, Otsuka T, Liu S, Yu Y, Liu W, Anver M, Navid F, Helman LJ, DePinho RA, Merlino G
Nat Med. 2002
PubMed ID: 12368906
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.
Hasan MK, Yaguchi T, Sugihara T, Kumar PK, Taira K, Reddel RR, Kaul SC, Wadhwa R
J Biol Chem. 2002
PubMed ID: 12154087
Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio.
Javelaud D, Besancon F
J Biol Chem. 2002
PubMed ID: 12151395
Human p14(Arf): an exquisite sensor of morphological changes and of short-lived perturbations in cell cycle and in nucleolar function.
David-Pfeuty T, Nouvian-Dooghe Y
Oncogene. 2002
PubMed ID: 12360404
Role of cell cycle regulator p19ARF in regulating T cell responses.
Gao X, Svaren J, Suresh M
Cell Immunol. 2002
PubMed ID: 12576030
Cloning of the 5' upstream region of the rat p16 gene and its role in silencing.
Abe M, Okochi E, Kuramoto T, Kaneda A, Takato T, Sugimura T, Ushijima T
Jpn J Cancer Res. 2002
PubMed ID: 12417039
An assessment of the CDKN2A variant Ala148Thr as a nevus/melanoma susceptibility allele.
Bertram CG, Gaut RM, Barrett JH, Pinney E, Whitaker L, Turner F, Bataille V, Dos Santos Silva I, J Swerdlow A, Bishop DT, Newton Bishop JA
J Invest Dermatol. 2002
PubMed ID: 12406345
p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma.
Taniai M, Higuchi H, Burgart LJ, Gores GJ
Gastroenterology. 2002
PubMed ID: 12360471
Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.
Uhrbom L, Dai C, Celestino JC, Rosenblum MK, Fuller GN, Holland EC
Cancer Res. 2002
PubMed ID: 12359767
Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92.
Calero Moreno TM, Gustafsson G, Garwicz S, Grandér D, Jonmundsson GK, Frost BM, Mäkipernaa A, Rasool O, Savolainen ER, Schmiegelow K, Söderhäll S, Vettenranta K, Wesenberg F, Einhorn S, Heyman M
Leukemia. 2002
PubMed ID: 12357355
Modulation of the expression of p16INK4a and p14ARF by hnRNP A1 and A2 RNA binding proteins: implications for cellular senescence.
Zhu D, Xu G, Ghandhi S, Hubbard K
J Cell Physiol. 2002
PubMed ID: 12209876
Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors.
Arcellana-Panlilio MY, Egeler RM, Ujack E, Magliocco A, Stuart GC, Robbins SM, Coppes MJ
Genes Chromosomes Cancer. 2002
PubMed ID: 12203782
A major functional difference between the mouse and human ARF tumor suppressor proteins.
Wadhwa R, Sugihara T, Hasan MK, Taira K, Reddel RR, Kaul SC
J Biol Chem. 2002
PubMed ID: 12145279
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.
Xirodimas DP, Chisholm J, Desterro JM, Lane DP, Hay RT
FEBS Lett. 2002
PubMed ID: 12297306
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation.
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA
Nature. 2002
PubMed ID: 12226664
[RB1 and CDKN2A functional defects resulting in retinoblastoma]
Babenko OV, Zemliakova VV, Saakian SV, Brovkina AF, Strel'nikov VV, Zaletaev DV, Nemtsova MV
Mol Biol (Mosk). 2002
PubMed ID: 12391839
Alteration of chromosome 9p21 and/or p16 in benign and dysplastic nevi suggests a role in early melanoma progression (United States).
Tran TP, Titus-Ernstoff L, Perry AE, Ernstoff MS, Newsham IF
Cancer Causes Control. 2002
PubMed ID: 12296515
Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.
Lemon WJ, Bernert H, Sun H, Wang Y, You M
J Med Genet. 2002
PubMed ID: 12205107
Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival.
Mateos MV, García-Sanz R, López-Pérez R, Moro MJ, Ocio E, Hernández J, Megido M, Caballero MD, Fernández-Calvo J, Bárez A, Almeida J, Orfão A, González M, San Miguel JF
Br J Haematol. 2002
PubMed ID: 12199782
Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents.
Tao L, Kramer PM, Wang W, Yang S, Lubet RA, Steele VE, Pereira MA
Carcinogenesis. 2002
PubMed ID: 12189186
Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.
Lund AH, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D, Russell R, DePinho RA, Lenz J, van Lohuizen M
Nat Genet. 2002
PubMed ID: 12185367
Loss of heterozygosity of p16 correlates with minimal residual disease at the end of the induction therapy in non-high risk childhood B-cell precursor acute lymphoblastic leukemia.
Tutor O, Díaz MA, Ramírez M, Algara P, Madero L, Martínez P
Leuk Res. 2002
PubMed ID: 12127556
Prognostic significance of p16INK4a alterations and 9p21 loss of heterozygosity in locally advanced laryngeal squamous cell carcinoma.
Bazan V, Zanna I, Migliavacca M, Sanz-Casla MT, Maestro ML, Corsale S, Macaluso M, Dardanoni G, Restivo S, Quintela PL, Bernaldez R, Salerno S, Morello V, Tomasino RM, Gebbia N, Russo A
J Cell Physiol. 2002
PubMed ID: 12124774
Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin.
Deng X, Kim M, Vandier D, Jung YJ, Rikiyama T, Sgagias MK, Goldsmith M, Cowan KH
Biochem Biophys Res Commun. 2002
PubMed ID: 12200117
A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression.
Zhang Z, Wang Y, Herzog CR, Liu G, Lee HW, DePinho RA, You M
Oncogene. 2002
PubMed ID: 12185599
ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphoma.
Grønbaek K, Worm J, Ralfkiaer E, Ahrenkiel V, Hokland P, Guldberg P
Blood. 2002
PubMed ID: 12149228
Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms.
Perry A, Kunz SN, Fuller CE, Banerjee R, Marley EF, Liapis H, Watson MA, Gutmann DH
J Neuropathol Exp Neurol. 2002
PubMed ID: 12152785
Loss of neurofibromatosis-1 and p19(ARF) cooperate to induce a multiple tumor phenotype.
King D, Yang G, Thompson MA, Hiebert SW
Oncogene. 2002
PubMed ID: 12118376
p53-independent apoptosis is induced by the p19ARF tumor suppressor.
Tsuji K, Mizumoto K, Sudo H, Kouyama K, Ogata E, Matsuoka M
Biochem Biophys Res Commun. 2002
PubMed ID: 12099684
Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation.
Lazaro JB, Bailey PJ, Lassar AB
Genes Dev. 2002
PubMed ID: 12130539
Aberrant methylation of the CDKN2a/p16INK4a gene promoter region in preinvasive bronchial lesions: a prospective study in high-risk patients without invasive cancer.
Lamy A, Sesboüé R, Bourguignon J, Dautréaux B, Métayer J, Frébourg T, Thiberville L
Int J Cancer. 2002
PubMed ID: 12115568
Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2.
Clark PA, Llanos S, Peters G
Oncogene. 2002
PubMed ID: 12085228
E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest.
Rowland BD, Denissov SG, Douma S, Stunnenberg HG, Bernards R, Peeper DS
Cancer Cell. 2002
PubMed ID: 12150825
Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase.
Straume O, Smeds J, Kumar R, Hemminki K, Akslen LA
Am J Pathol. 2002
PubMed ID: 12107107
Haplotypes of two variants in p16 (CDKN2/MTS-1/INK4a) exon 3 and risk of squamous cell carcinoma of the head and neck: a case-control study.
Zheng Y, Shen H, Sturgis EM, Wang LE, Shete S, Spitz MR, Wei Q
Cancer Epidemiol Biomarkers Prev. 2002
PubMed ID: 12101111
The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.
Linggi B, Müller-Tidow C, van de Locht L, Hu M, Nip J, Serve H, Berdel WE, van der Reijden B, Quelle DE, Rowley JD, Cleveland J, Jansen JH, Pandolfi PP, Hiebert SW
Nat Med. 2002
PubMed ID: 12091906
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Rheinwald JG, Hahn WC, Ramsey MR, Wu JY, Guo Z, Tsao H, De Luca M, Catricalà C, O'Toole KM
Mol Cell Biol. 2002
PubMed ID: 12077343
Patterns of gene promoter methylation in squamous cell cancer of the head and neck.
Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT
Oncogene. 2002
PubMed ID: 12082610
p14(ARF) regulates E2F activity.
Mason SL, Loughran O, La Thangue NB
Oncogene. 2002
PubMed ID: 12082609
Geographical variation in the penetrance of CDKN2A mutations for melanoma.
Bishop DT, Demenais F, Goldstein AM, Bergman W, Bishop JN, Bressac-de Paillerets B, Chompret A, Ghiorzo P, Gruis N, Hansson J, Harland M, Hayward N, Holland EA, Mann GJ, Mantelli M, Nancarrow D, Platz A, Tucker MA, Melanoma Genetics Consortium
J Natl Cancer Inst. 2002
PubMed ID: 12072543
Genetic epidemiology of melanoma: of consortia and conundrums.
Petersen GM, Vachon CM
J Natl Cancer Inst. 2002
PubMed ID: 12072536
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence.
Brookes S, Rowe J, Ruas M, Llanos S, Clark PA, Lomax M, James MC, Vatcheva R, Bates S, Vousden KH, Parry D, Gruis N, Smit N, Bergman W, Peters G
EMBO J. 2002
PubMed ID: 12065407
Deletion analysis of p16(INKa) and p15(INKb) in relapsed childhood acute lymphoblastic leukemia.
Graf Einsiedel H, Taube T, Hartmann R, Wellmann S, Seifert G, Henze G, Seeger K
Blood. 2002
PubMed ID: 12036898
Immunohistochemical study of the expression of cell cycle regulating proteins at different stages of bladder cancer.
Primdahl H, von der Maase H, Sørensen FB, Wolf H, Ørntoft TF
J Cancer Res Clin Oncol. 2002
PubMed ID: 12073046
Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma.
Child FJ, Scarisbrick JJ, Calonje E, Orchard G, Russell-Jones R, Whittaker SJ
J Invest Dermatol. 2002
PubMed ID: 12060387
Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China.
Zhou Y, Gao SS, Li YX, Fan ZM, Zhao X, Qi YJ, Wei JP, Zou JX, Liu G, Jiao LH, Bai YM, Wang LD
World J Gastroenterol. 2002
PubMed ID: 12046062
Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer.
Kudoh K, Ichikawa Y, Yoshida S, Hirai M, Kikuchi Y, Nagata I, Miwa M, Uchida K
Int J Cancer. 2002
PubMed ID: 11992549
Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.
Zhang B, Peng ZY
Biochemistry. 2002
PubMed ID: 12009890
Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland.
Foster CJ, Lozano G
Oncogene. 2002
PubMed ID: 12032854
Germline mutation of ARF in a melanoma kindred.
Hewitt C, Lee Wu C, Evans G, Howell A, Elles RG, Jordan R, Sloan P, Read AP, Thakker N
Hum Mol Genet. 2002
PubMed ID: 12019208
p16(INK4a) and p53 deficiency cooperate in tumorigenesis.
Sharpless NE, Alson S, Chan S, Silver DP, Castrillon DH, DePinho RA
Cancer Res. 2002
PubMed ID: 12019151
Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways.
Weber HO, Samuel T, Rauch P, Funk JO
Oncogene. 2002
PubMed ID: 12082636
Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis.
Hemmati PG, Gillissen B, von Haefen C, Wendt J, Stärck L, Güner D, Dörken B, Daniel PT
Oncogene. 2002
PubMed ID: 12082630
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.
Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW
Cell. 2002
PubMed ID: 12015983
Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2.
Palmero I, Murga M, Zubiaga A, Serrano M
Oncogene. 2002
PubMed ID: 12082524
[Prognostic importance of altered expression of cell cycle regulators in lung cancer]
Akita H
Nippon Rinsho. 2002
PubMed ID: 12101670
Senescence: a companion in chemotherapy?
Berns A
Cancer Cell. 2002
PubMed ID: 12086843
Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway.
Ouyang XS, Wang X, Ling MT, Wong HL, Tsao SW, Wong YC
Carcinogenesis. 2002
PubMed ID: 12016143
Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma.
Fukushima N, Sato N, Ueki T, Rosty C, Walter KM, Wilentz RE, Yeo CJ, Hruban RH, Goggins M
Am J Pathol. 2002
PubMed ID: 12000709
A head holder for magnetic resonance imaging that allows the stereotaxic alignment of spontaneously occurring intracranial mouse tumors.
Tada T, Wendland M, Watson N, Kuriyama N, Kuriyama H, Roberts T, Burns M, Weiss W, Israel MA
J Neurosci Methods. 2002
PubMed ID: 12007978
Cirrhotic livers reveal genetic changes in the MDM2-P14ARF system of cell cycle regulators.
Schlott T, Scharf JG, Gorzel C, Middel P, Spring H
Br J Cancer. 2002
PubMed ID: 11953887
Glutathione S-transferase P1 and NADPH quinone oxidoreductase polymorphisms are associated with aberrant promoter methylation of P16(INK4a) and O(6)-methylguanine-DNA methyltransferase in sputum.
Gilliland FD, Harms HJ, Crowell RE, Li YF, Willink R, Belinsky SA
Cancer Res. 2002
PubMed ID: 11956078
Alterations of the p16(ink4a) gene in resected nonsmall cell lung tumors and exfoliated cells within sputum.
Chen JT, Chen YC, Wang YC, Tseng RC, Chen CY, Wang YC
Int J Cancer. 2002
PubMed ID: 11920642
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.
Wigle JT, Harvey N, Detmar M, Lagutina I, Grosveld G, Gunn MD, Jackson DG, Oliver G
EMBO J. 2002
PubMed ID: 11927535
Rapid tissue microarray assay of p16 protein expression for different stage nasopharyngeal carcinoma.
Zhang L, Fang Y, Huang B, Hou J, Zhao M, Li H, Zeng Y
Zhonghua Bing Li Xue Za Zhi. 2002
PubMed ID: 12419160
MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis.
Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA
J Cell Mol Med. 2002
PubMed ID: 12169206
Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation.
Smeds J, Berggren P, Ma X, Xu Z, Hemminki K, Kumar R
Carcinogenesis. 2002
PubMed ID: 11960918
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
Domínguez G, Carballido J, Silva J, Silva JM, García JM, Menéndez J, Provencio M, España P, Bonilla F
Clin Cancer Res. 2002
PubMed ID: 11948103
Loss of Bax alters tumor spectrum and tumor numbers in ARF-deficient mice.
Eischen CM, Rehg JE, Korsmeyer SJ, Cleveland JL
Cancer Res. 2002
PubMed ID: 11929842
Activation of caspase-3 and cleavage of Rb are associated with p16-mediated apoptosis in human non-small cell lung cancer cells.
Katsuda K, Kataoka M, Uno F, Murakami T, Kondo T, Roth JA, Tanaka N, Fujiwara T
Oncogene. 2002
PubMed ID: 11960384
The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development.
McKeller RN, Fowler JL, Cunningham JJ, Warner N, Smeyne RJ, Zindy F, Skapek SX
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11891301
Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.
Parisi T, Pollice A, Di Cristofano A, Calabrò V, La Mantia G
Biochem Biophys Res Commun. 2002
PubMed ID: 11883935
Mts1 protein expression in the central nervous system after injury.
Kozlova EN, Lukanidin E
Glia. 2002
PubMed ID: 11870873
Genetic alterations of INK4alpha/ARF locus and p53 in human hepatocellular carcinoma.
Peng CY, Chen TC, Hung SP, Chen MF, Yeh CT, Tsai SL, Chu CM, Liaw YF
Anticancer Res. 2002
PubMed ID: 12168936
Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines.
Park YB, Park MJ, Kimura K, Shimizu K, Lee SH, Yokota J
Cancer Genet Cytogenet. 2002
PubMed ID: 11943335
Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome.
Scarisbrick JJ, Woolford AJ, Calonje E, Photiou A, Ferreira S, Orchard G, Russell-Jones R, Whittaker SJ
J Invest Dermatol. 2002
PubMed ID: 11874489
Transgenic expression of the p16(INK4a) cyclin-dependent kinase inhibitor leads to enhanced apoptosis and differentiation arrest of CD4-CD8- immature thymocytes.
Lagresle C, Gardie B, Eyquem S, Fasseu M, Vieville JC, Pla M, Sigaux F, Bories JC
J Immunol. 2002
PubMed ID: 11859122
ARF differentially modulates apoptosis induced by E2F1 and Myc.
Russell JL, Powers JT, Rounbehler RJ, Rogers PM, Conti CJ, Johnson DG
Mol Cell Biol. 2002
PubMed ID: 11839803
Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomas.
Ichikawa K, Imura J, Kawamata H, Takeda J, Fujimori T
Int J Oncol. 2002
PubMed ID: 11836554
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.
Brummelkamp TR, Kortlever RM, Lingbeek M, Trettel F, MacDonald ME, van Lohuizen M, Bernards R
J Biol Chem. 2002
PubMed ID: 11748239
Human tumor suppressor ARF impedes S-phase progression independent of p53.
Yarbrough WG, Bessho M, Zanation A, Bisi JE, Xiong Y
Cancer Res. 2002
PubMed ID: 11861400
p14(ARF) nuclear overexpression in aggressive B-cell lymphomas is a sensor of malfunction of the common tumor suppressor pathways.
Sánchez-Aguilera A, Sánchez-Beato M, García JF, Prieto I, Pollan M, Piris MA
Blood. 2002
PubMed ID: 11830494
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11818530
Aberrant CpG island methylation of the p16(INK4a) and estrogen receptor genes in rat lung tumors induced by particulate carcinogens.
Belinsky SA, Snow SS, Nikula KJ, Finch GL, Tellez CS, Palmisano WA
Carcinogenesis. 2002
PubMed ID: 11872642
p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides.
Navas IC, Algara P, Mateo M, Martínez P, García C, Rodriguez JL, Vanaclocha F, Barrientos N, Iglesias L, Sánchez L, Piris MA, Ortiz-Romero P
Lab Invest. 2002
PubMed ID: 11850526
Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients.
Chan MW, Chan LW, Tang NL, Tong JH, Lo KW, Lee TL, Cheung HY, Wong WS, Chan PS, Lai FM, To KF
Clin Cancer Res. 2002
PubMed ID: 11839665
Nucleolar p14(ARF) overexpression in Reed-Sternberg cells in Hodgkin's lymphoma: absence of p14(ARF)/Hdm2 complexes is associated with expression of alternatively spliced Hdm2 transcripts.
García JF, Villuendas R, Sánchez-Beato M, Sánchez-Aguilera A, Sánchez L, Prieto I, Piris MA
Am J Pathol. 2002
PubMed ID: 11839577
Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis.
Hiroyasu M, Ozeki M, Kohda H, Echizenya M, Tanaka T, Hiai H, Toyokuni S
Am J Pathol. 2002
PubMed ID: 11839561
Co-transfection of p16(INK4a) and p53 genes into the K562 cell line inhibits cell proliferation.
Rui HB, Su JZ
Haematologica. 2002
PubMed ID: 11836163
JunB can substitute for Jun in mouse development and cell proliferation.
Passegué E, Jochum W, Behrens A, Ricci R, Wagner EF
Nat Genet. 2002
PubMed ID: 11818961
Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4.
Angel JM, Richie ER
Mol Carcinog. 2002
PubMed ID: 11813303
ARF is not required for apoptosis in Rb mutant mouse embryos.
Tsai KY, MacPherson D, Rubinson DA, Crowley D, Jacks T
Curr Biol. 2002
PubMed ID: 11818069
High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families.
Mantelli M, Barile M, Ciotti P, Ghiorzo P, Lantieri F, Pastorino L, Catricalà C, Torre GD, Folco U, Grammatico P, Padovani L, Pasini B, Rovini D, Queirolo P, Rainero ML, Santi PL, Sertoli RM, Goldstein AM, Bianchi-Scarrà G, Società Italiana Dermatologia, Gruppo Italiano Studi Epidemiologici in Dermatologia
Am J Med Genet. 2002
PubMed ID: 11807902
p16INK4A and p14ARF tumour suppressors in melanoma: lessons from the mouse.
Walker GJ, Hayward NK
Lancet. 2002
PubMed ID: 11809177
Expression of p16 in sporadic primary uveal melanoma.
Lamperska K, Mackiewicz K, Kaczmarek A, Kwiatkowska E, Starzycka M, Romanowska B, Heizman J, Stachura J, Mackiewicz A
Acta Biochim Pol. 2002
PubMed ID: 12362979
Analysis of mutations in the p16/CDKN2A gene in sporadic and familial melanoma in the Polish population.
Lamperska K, Karezewska A, Kwiatkowska E, Mackiewicz A
Acta Biochim Pol. 2002
PubMed ID: 12362978
Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase.
Govindarajan B, Klafter R, Miller MS, Mansur C, Mizesko M, Bai X, LaMontagne K, Arbiser JL
Mol Med. 2002
PubMed ID: 11984000
[Expression of the protein marker p16INK4a in the cervix uteri cancer]
Volgareva GM, Zavalishina LE, Frank GA, Andreeva IuIu, Petrov AN, Kiselev FL, Spitkovskiĭ DD
Arkh Patol. 2002
PubMed ID: 11889694
Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome.
Korshunov A, Golanov A
Arch Pathol Lab Med. 2002
PubMed ID: 11800646
Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.
Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, Merlino G, DePinho RA
Mol Cell Biol. 2002
PubMed ID: 11756558
Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumors.
Orlow I, Cordon-Cardo C
Methods Mol Biol. 2002
PubMed ID: 11692873
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, Whitsett JA, Koretsky A, Varmus HE
Genes Dev. 2001
PubMed ID: 11751631
Regulation of cyclin D1 and p16(INK4A) is critical for growth arrest during mammary involution.
Gadd M, Pisc C, Branda J, Ionescu-Tiba V, Nikolic Z, Yang C, Wang T, Shackleford GM, Cardiff RD, Schmidt EV
Cancer Res. 2001
PubMed ID: 11751403
Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression.
Simon M, Park TW, Köster G, Mahlberg R, Hackenbroch M, Boström J, Löning T, Schramm J
J Neurooncol. 2001
PubMed ID: 11859969
Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA
Mol Cell. 2001
PubMed ID: 11779495
Aberrations of the p14(ARF) and p16(INK4a) genes in renal cell carcinomas.
Kawada Y, Nakamura M, Ishida E, Shimada K, Oosterwijk E, Uemura H, Hirao Y, Chul KS, Konishi N
Jpn J Cancer Res. 2001
PubMed ID: 11749694
CAK-independent activation of CDK6 by a viral cyclin.
Kaldis P, Ojala PM, Tong L, Mäkelä TP, Solomon MJ
Mol Biol Cell. 2001
PubMed ID: 11739795
Expression of cell-cycle mediators in ovarian cancer cells after transfection with p16(INK4a), p21(WAF1/Cip-1), and p53.
Ramirez PT, Gershenson DM, Tortolero-Luna G, Ramondetta LM, Fightmaster D, Wharton JT, Wolf JK
Gynecol Oncol. 2001
PubMed ID: 11733969
Defining the molecular basis of Arf and Hdm2 interactions.
Bothner B, Lewis WS, DiGiammarino EL, Weber JD, Bothner SJ, Kriwacki RW
J Mol Biol. 2001
PubMed ID: 11718560
The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis.
Paramio JM, Segrelles C, Ruiz S, Martin-Caballero J, Page A, Martinez J, Serrano M, Jorcano JL
J Biol Chem. 2001
PubMed ID: 11551927
A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare.
Kumar R, Smeds J, Berggren P, Straume O, Rozell BL, Akslen LA, Hemminki K
Int J Cancer. 2001
PubMed ID: 11668523
Influence of human p16(INK4) and p21(CIP1) on the in vitro activity of recombinant Plasmodium falciparum cyclin-dependent protein kinases.
Li Z, Le Roch K, Geyer JA, Woodard CL, Prigge ST, Koh J, Doerig C, Waters NC
Biochem Biophys Res Commun. 2001
PubMed ID: 11700040
p16(INK4a) lesions are common, early abnormalities that undergo clonal expansion in Barrett's metaplastic epithelium.
Wong DJ, Paulson TG, Prevo LJ, Galipeau PC, Longton G, Blount PL, Reid BJ
Cancer Res. 2001
PubMed ID: 11719461
Invasive melanoma in Cdk4-targeted mice.
Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11606789
No germline mutations in CDKN2A (p16) in patients with squamous cell cancer of the head and neck and second primary tumours.
Jefferies S, Edwards SM, Hamoudi RA, A'Hern R, Foulkes W, Goldgar D, Eeles R, MPT Collaborators
Br J Cancer. 2001
PubMed ID: 11720478
Analysis of the p16 gene status of non-familial dysplastic nevus syndrome patients.
Matsumura Y, Nishigori C, Miyachi Y
Arch Dermatol Res. 2001
PubMed ID: 11820732
A deep intronic mutation in CDKN2A is associated with disease in a subset of melanoma pedigrees.
Harland M, Mistry S, Bishop DT, Bishop JA
Hum Mol Genet. 2001
PubMed ID: 11726555
p16/p14(ARF) cell cycle regulatory pathways in primary neuroblastoma: p16 expression is associated with advanced stage disease.
Omura-Minamisawa M, Diccianni MB, Chang RC, Batova A, Bridgeman LJ, Schiff J, Cohn SL, London WB, Yu AL
Clin Cancer Res. 2001
PubMed ID: 11705866
Validation of denaturing high performance liquid chromatography as a rapid detection method for the identification of human INK4A gene mutations.
Orlow I, Roy P, Barz A, Canchola R, Song Y, Berwick M
J Mol Diagn. 2001
PubMed ID: 11687599
Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.
Eischen CM, Roussel MF, Korsmeyer SJ, Cleveland JL
Mol Cell Biol. 2001
PubMed ID: 11604501
Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells.
Muscarella P, Knobloch TJ, Ulrich AB, Casto BC, Moniaux N, Wittel UA, Melvin WS, Pour PM, Song H, Gold B, Batra SK, Weghorst CM
Gene. 2001
PubMed ID: 11707341
Homozygous deletion of INK4a/ARF genes and overexpression of bcl-2 in relation with poor prognosis in immunocompetent patients with primary central nervous system lymphoma of the diffuse large B-cell type.
Hayashi Y, Iwato M, Arakawa Y, Fujisawa H, Thoma Y, Hasegawa M, Tachibana O, Yamashita J
J Neurooncol. 2001
PubMed ID: 11804283
Immunohistochemical expression of p53, p21/waf1, rb, p16, cyclin D1, p27, Ki67, cyclin A, cyclin B1, bcl2, bax and bak proteins and apoptotic index in normal thymus.
Kanavaros P, Stefanaki K, Rontogianni D, Papalazarou D, Sgantzos M, Arvanitis D, Vamvouka C, Gorgoulis V, Siatitsas I, Agnantis NJ, Bai M
Histol Histopathol. 2001
PubMed ID: 11642719
MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations.
Box NF, Duffy DL, Chen W, Stark M, Martin NG, Sturm RA, Hayward NK
Am J Hum Genet. 2001
PubMed ID: 11500805
CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutation.
Della Torre G, Pasini B, Frigerio S, Donghi R, Rovini D, Delia D, Peters G, Huot TJ, Bianchi-Scarra G, Lantieri F, Rodolfo M, Parmiani G, Pierotti MA
Br J Cancer. 2001
PubMed ID: 11556834
Comparisons of tumor suppressor p53, p21, and p16 gene therapy effects on glioblastoma tumorigenicity in situ.
Wang TJ, Huang MS, Hong CY, Tse V, Silverberg GD, Hsiao M
Biochem Biophys Res Commun. 2001
PubMed ID: 11549271
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.
Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA
Nature. 2001
PubMed ID: 11544531
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.
Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A
Nature. 2001
PubMed ID: 11544530
[Influence of suppressor gene p16 on retinoic acid inducing lung cancer cell A549 differentiation]
Bai M, Zhang X, Jin Y
Zhonghua Jie He He Hu Xi Za Zhi. 2001
PubMed ID: 11758167
Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines.
Agiostratidou G, Derventzi A, Gonos ES
In Vivo. 2001
PubMed ID: 11695244
A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families.
Goldstein AM, Liu L, Shennan MG, Hogg D, Tucker MA, Struewing JP
Br J Cancer. 2001
PubMed ID: 11506491
CDKN2A/p16 in ependymomas.
Bortolotto S, Chiadò-Piat L, Cavalla P, Bosone I, Mauro A, Schiffer D
J Neurooncol. 2001
PubMed ID: 11763427
Identification of the gene immediately downstream of the murine INK4a/ARF locus.
Pantoja C, Palmero I, Serrano M
Exp Gerontol. 2001
PubMed ID: 11602205
Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis.
Eischen CM, Woo D, Roussel MF, Cleveland JL
Mol Cell Biol. 2001
PubMed ID: 11438662
The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
Fatyol K, Szalay AA
J Biol Chem. 2001
PubMed ID: 11382768
MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation.
Jackson MW, Lindstrom MS, Berberich SJ
J Biol Chem. 2001
PubMed ID: 11297540
Genetically engineered mouse models of astrocytoma: GEMs in the rough?
Reilly KM, Jacks T
Semin Cancer Biol. 2001
PubMed ID: 11407943
Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.
Sugihara T, Kaul SC, Kato J, Reddel RR, Nomura H, Wadhwa R
J Biol Chem. 2001
PubMed ID: 11259404
Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression.
Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H
Development. 2001
PubMed ID: 11290297
The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein.
Vivo M, Calogero RA, Sansone F, Calabrò V, Parisi T, Borrelli L, Saviozzi S, La Mantia G
J Biol Chem. 2001
PubMed ID: 11278317
Control of p53 ubiquitination and nuclear export by MDM2 and ARF.
Zhang Y, Xiong Y
Cell Growth Differ. 2001
PubMed ID: 11331246
Human ARF binds E2F1 and inhibits its transcriptional activity.
Eymin B, Karayan L, Séité P, Brambilla C, Brambilla E, Larsen CJ, Gazzéri S
Oncogene. 2001
PubMed ID: 11314038
Dual inactivation of RB and p53 pathways in RAS-induced melanomas.
Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L
Mol Cell Biol. 2001
PubMed ID: 11238948
Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice.
Lu Y, Lian H, Sharma P, Schreiber-Agus N, Russell RG, Chin L, van der Horst GT, Bregman DB
Mol Cell Biol. 2001
PubMed ID: 11238917
Solution structure of the p53 regulatory domain of the p19Arf tumor suppressor protein.
DiGiammarino EL, Filippov I, Weber JD, Bothner B, Kriwacki RW
Biochemistry. 2001
PubMed ID: 11327858
MDM2 and MDMX can interact differently with ARF and members of the p53 family.
Wang X, Arooz T, Siu WY, Chiu CH, Lau A, Yamashita K, Poon RY
FEBS Lett. 2001
PubMed ID: 11223036
The sequence of the human genome.
Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
Science. 2001
PubMed ID: 11181995
Human ARF protein interacts with topoisomerase I and stimulates its activity.
Karayan L, Riou JF, Séité P, Migeon J, Cantereau A, Larsen CJ
Oncogene. 2001
PubMed ID: 11314011
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
Wetmore C, Eberhart DE, Curran T
Cancer Res. 2001
PubMed ID: 11212243
p16/INK4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies.
Mateos MV, Garcia-Sanz R, López-Pérez R, Balanzategui A, González MI, Fernández-Calvo J, Moro MJ, Hernández J, Caballero MD, González M, San Miguel JF
Hematol J. 2001
PubMed ID: 11920239
Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more common in null cell adenomas.
Ruebel KH, Jin L, Zhang S, Scheithauer BW, Lloyd RV
Endocr Pathol. 2001
PubMed ID: 11740049
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.
Randerson-Moor JA, Harland M, Williams S, Cuthbert-Heavens D, Sheridan E, Aveyard J, Sibley K, Whitaker L, Knowles M, Bishop JN, Bishop DT
Hum Mol Genet. 2001
PubMed ID: 11136714
Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.
Zhang SL, DuBois W, Ramsay ES, Bliskovski V, Morse HC, Taddesse-Heath L, Vass WC, DePinho RA, Mock BA
Mol Cell Biol. 2001
PubMed ID: 11113205
CDKN2A germ-line mutations in individuals with multiple cutaneous melanomas.
Hashemi J, Platz A, Ueno T, Stierner U, Ringborg U, Hansson J
Cancer Res. 2000
PubMed ID: 11156381
[The expression of P16, P21(WAF1/CIP1) and Cyclin D1 proteins in skin of patients with arseniasis caused by coal-burning and their significance]
Hong F, Zhang A, Huang X, Liu Z
Zhonghua Yu Fang Yi Xue Za Zhi. 2000
PubMed ID: 11860939
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
p53-independent functions of the p19(ARF) tumor suppressor.
Weber JD, Jeffers JR, Rehg JE, Randle DH, Lozano G, Roussel MF, Sherr CJ, Zambetti GP
Genes Dev. 2000
PubMed ID: 10995391
Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).
Vasen HF, Gruis NA, Frants RR, van Der Velden PA, Hille ET, Bergman W
Int J Cancer. 2000
PubMed ID: 10956390
[Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene].
Maestro de las Casas ML, Sanz-Casla MT, del Barco V, Moreno J, Zanna I, Redondo E, Fernández C, Izquierdo L, Resel Estévez L
Arch Esp Urol. 2000
PubMed ID: 11037653
Gene-covariate interaction between dysplastic nevi and the CDKN2A gene in American melanoma-prone families.
Goldstein AM, Martinez M, Tucker MA, Demenais F
Cancer Epidemiol Biomarkers Prev. 2000
PubMed ID: 11008905
Hypermethylation of the p16 (Ink4a) promoter in B6C3F1 mouse primary lung adenocarcinomas and mouse lung cell lines.
Patel AC, Anna CH, Foley JF, Stockton PS, Tyson FL, Barrett JC, Devereux TR
Carcinogenesis. 2000
PubMed ID: 10964101
Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats.
Fong LY, Nguyen VT, Farber JL, Huebner K, Magee PN
Cancer Res. 2000
PubMed ID: 10969811
Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.
Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, Bond JA
Mol Cell Biol. 2000
PubMed ID: 10891505
Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis.
Inoue K, Wen R, Rehg JE, Adachi M, Cleveland JL, Roussel MF, Sherr CJ
Genes Dev. 2000
PubMed ID: 10898794
DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway.
Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW
Mol Cell. 2000
PubMed ID: 10911993
Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data.
Yuan C, Selby TL, Li J, Byeon IJ, Tsai MD
Protein Sci. 2000
PubMed ID: 10892805
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo.
Midgley CA, Desterro JM, Saville MK, Howard S, Sparks A, Hay RT, Lane DP
Oncogene. 2000
PubMed ID: 10822382
The INK4a/ARF locus in murine tumorigenesis.
Serrano M
Carcinogenesis. 2000
PubMed ID: 10783305
Cell-cycle inhibitors: three families united by a common cause.
Vidal A, Koff A
Gene. 2000
PubMed ID: 10773440
Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas.
Meléndez B, Malumbres M, de Castro IP, Santos J, Pellicer A, Fernández-Piqueras J
Carcinogenesis. 2000
PubMed ID: 10753221
P16 overexpression in pituitary adenomas studied by immunohistochemistry and in situ hybridization.
Yi J, Yu D, Chen Y, Xiong W, Li X, Shen J, Tang X
Chin Med J (Engl). 2000
PubMed ID: 11775544
DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model.
Schmitt CA, Wallace-Brodeur RR, Rosenthal CT, McCurrach ME, Lowe SW
Cold Spring Harb Symp Quant Biol. 2000
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Identification and mapping of swine cyclin-dependent kinase inhibitor CDKN2A and CDKN2B exon 2 sequences.
Le Chalony C, Hayes H, Frelat G, Geffrotin C
Cytogenet Cell Genet. 2000
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A mouse model for glioma: biology, pathology, and therapeutic opportunities.
Holland EC
Toxicol Pathol. 2000
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[Effect of inactivating various components of the signal pathways of the tumor suppressor p53 on genomic stability]
Turovets NA, Chumakov PM, Kopnin BP
Genetika. 1999
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Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation.
Nielsen GP, Stemmer-Rachamimov AO, Ino Y, Moller MB, Rosenberg AE, Louis DN
Am J Pathol. 1999
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Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).
Yuan C, Li J, Selby TL, Byeon IJ, Tsai MD
J Mol Biol. 1999
PubMed ID: 10556039
Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1).
Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E
Genes Dev. 1999
PubMed ID: 10580009
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.
Schmitt CA, McCurrach ME, de Stanchina E, Wallace-Brodeur RR, Lowe SW
Genes Dev. 1999
PubMed ID: 10541553
Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis.
Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL
Genes Dev. 1999
PubMed ID: 10541552
Modeling human lung cancer in mice: similarities and shortcomings.
Tuveson DA, Jacks T
Oncogene. 1999
PubMed ID: 10498884
The INK4 family of cell cycle inhibitors in cancer.
Roussel MF
Oncogene. 1999
PubMed ID: 10498883
Modeling malignant melanoma in mice: pathogenesis and maintenance.
Chin L
Oncogene. 1999
PubMed ID: 10498882
Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors.
Yarbrough WG, Buckmire RA, Bessho M, Liu ET
J Natl Cancer Inst. 1999
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Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family.
Güran S, Tunca Y, Imirzalioğlu N
Cancer Genet Cytogenet. 1999
PubMed ID: 10484981
Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.
Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, Chao MV
Development. 1999
PubMed ID: 10457012
For better or worse? Telomerase inhibition and cancer.
de Lange T, Jacks T
Cell. 1999
PubMed ID: 10458601
Essential role for oncogenic Ras in tumour maintenance.
Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA
Nature. 1999
PubMed ID: 10440378
Loss of heterozygosity at the proximal-mid part of mouse chromosome 4 defines two novel tumor suppressor gene loci in T-cell lymphomas.
Meléndez B, Santos J, Fernández-Piqueras J
Oncogene. 1999
PubMed ID: 10435599
Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus.
Robertson KD, Jones PA
Oncogene. 1999
PubMed ID: 10445844
Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis.
Orlow I, Rabbani F, Chin L, Pomerantz J, Ligeois N, Dudas M, Depinho R, Cordón-Cardó C
Int J Oncol. 1999
PubMed ID: 10375589
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.
Tao W, Levine AJ
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10359817
CDKN2A mutations in Spanish cutaneous malignant melanoma families and patients with multiple melanomas and other neoplasia.
Ruiz A, Puig S, Malvehy J, Lázaro C, Lynch M, Gimenez-Arnau AM, Puig L, Sánchez-Conejo J, Estivill X, Castel T
J Med Genet. 1999
PubMed ID: 10874641
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.
Kamijo T, van de Kamp E, Chong MJ, Zindy F, Diehl JA, Sherr CJ, McKinnon PJ
Cancer Res. 1999
PubMed ID: 10344759
Elevated frequency of loss of heterozygosity in mammary tumors arising in mouse mammary tumor virus/neu transgenic mice.
Cool M, Jolicoeur P
Cancer Res. 1999
PubMed ID: 10344755
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse.
Greenberg RA, Chin L, Femino A, Lee KH, Gottlieb GJ, Singer RH, Greider CW, DePinho RA
Cell. 1999
PubMed ID: 10338215
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.
Zhang Y, Xiong Y
Mol Cell. 1999
PubMed ID: 10360174
Tumor spectrum in ARF-deficient mice.
Kamijo T, Bodner S, van de Kamp E, Randle DH, Sherr CJ
Cancer Res. 1999
PubMed ID: 10232611
INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB.
Wolff B, Naumann M
Oncogene. 1999
PubMed ID: 10353611
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.
Fåhraeus R, Lane DP
EMBO J. 1999
PubMed ID: 10205165
[A study on homozygous deletion, hypermethylation, mutation and expression of p16 gene in human breast cancer]
Guo S, Liao S, Meng Z, Liu J, Huang M, Wang D, Ding H
Zhonghua Bing Li Xue Za Zhi. 1999
PubMed ID: 11869517
Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.
Inoue K, Roussel MF, Sherr CJ
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10097151
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity.
Schreiber M, Muller WJ, Singh G, Graham FL
Oncogene. 1999
PubMed ID: 10208428
[The mechanism of p16 gene inactivation in human bladder transitional cell carcinoma]
Wu Y, Wu H, Ma T, Wu C
Zhonghua Bing Li Xue Za Zhi. 1999
PubMed ID: 11869511
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.
Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M
Nature. 1999
PubMed ID: 9923679
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
Honda R, Yasuda H
EMBO J. 1999
PubMed ID: 9878046
A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors.
Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX
Hum Mol Genet. 1999
PubMed ID: 9887329
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The p53 pathway.
Prives C, Hall PA
J Pathol. 1999
PubMed ID: 10341712
Genetic events and the role of TGF beta in epithelial tumour progression.
Akhurst RJ, Balmain A
J Pathol. 1999
PubMed ID: 10341708
Insights into cancer from transgenic mouse models.
Macleod KF, Jacks T
J Pathol. 1999
PubMed ID: 10341706
Mouse models in tumor suppression.
Ghebranious N, Donehower LA
Oncogene. 1998
PubMed ID: 9917000
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P
Biochem J. 1998
PubMed ID: 9841865
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.
Holland EC, Hively WP, DePinho RA, Varmus HE
Genes Dev. 1998
PubMed ID: 9851974
Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.
Holland EC, Hively WP, Gallo V, Varmus HE
Genes Dev. 1998
PubMed ID: 9851971
Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: a Kit-KL interaction critical for meiosis.
Vincent S, Segretain D, Nishikawa S, Nishikawa SI, Sage J, Cuzin F, Rassoulzadegan M
Development. 1998
PubMed ID: 9778516
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Russo AA, Tong L, Lee JO, Jeffrey PD, Pavletich NP
Nature. 1998
PubMed ID: 9751050
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
Stott FJ, Bates S, James MC, McConnell BB, Starborg M, Brookes S, Palmero I, Ryan K, Hara E, Vousden KH, Peters G
EMBO J. 1998
PubMed ID: 9724636
E1A signaling to p53 involves the p19(ARF) tumor suppressor.
de Stanchina E, McCurrach ME, Zindy F, Shieh SY, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ, Lowe SW
Genes Dev. 1998
PubMed ID: 9694807
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.
Kamijo T, Weber JD, Zambetti G, Zindy F, Roussel MF, Sherr CJ
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9653180
Molecular comparison of human and mouse pulmonary adenocarcinomas.
Malkinson AM
Exp Lung Res. 1998
PubMed ID: 9659582
Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.
Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA
Nature. 1998
PubMed ID: 9624006
Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.
Gressani KM, Rollins LA, Leone-Kabler S, Cline JM, Miller MS
Carcinogenesis. 1998
PubMed ID: 9667743
Release of cell cycle constraints in mouse melanocytes by overexpressed mutant E2F1E132, but not by deletion of p16INK4A or p21WAF1/CIP1.
Halaban R, Cheng E, Zhang Y, Mandigo CE, Miglarese MR
Oncogene. 1998
PubMed ID: 9627115
Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors.
Heidenreich A, Gaddipati JP, Moul JW, Srivastava S
J Urol. 1998
PubMed ID: 9554401
CDKN2A mutations in multiple primary melanomas.
Monzon J, Liu L, Brill H, Goldstein AM, Tucker MA, From L, McLaughlin J, Hogg D, Lassam NJ
N Engl J Med. 1998
PubMed ID: 9516223
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Zhang Y, Xiong Y, Yarbrough WG
Cell. 1998
PubMed ID: 9529249
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.
Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA
Cell. 1998
PubMed ID: 9529248
Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.
Zhang S, Ramsay ES, Mock BA
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9482902
An AC-repeat adjacent to mouse Cdkn2B allows the detection of specific allelic losses in the p15INK4b and p16INK4a tumor suppressor genes.
Malumbres M, Pérez de Castro I, Santos J, Pérez-Ollé R, Fernández-Piqueras J, Pellicer A
Mamm Genome. 1998
PubMed ID: 9501299
Inactivations of p16INK4a-alpha, p16INK4a-beta and p15INK4b genes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas.
Zhuang SM, Schippert A, Haugen-Strano A, Wiseman RW, Söderkvist P
Oncogene. 1998
PubMed ID: 9488045
Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule.
Fåhraeus R, Laín S, Ball KL, Lane DP
Oncogene. 1998
PubMed ID: 9482104
Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group.
Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A, Stoppa-Lyonnet D, Bénard J, Bressac-de Paillerets B
Hum Mol Genet. 1998
PubMed ID: 9425228
Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation.
Sunters A, McCluskey J, Grigoriadis AE
Dev Genet. 1998
PubMed ID: 9664690
Five novel somatic CDKN2/p16 mutations identified in melanoma, glioma and carcinoma of the pancreas. Mutations in brief no. 170. Online.
Gretarsdóttir S, Olafsdóttir GH, Borg A
Hum Mutat. 1998
PubMed ID: 10651484
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.
Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ
Cell. 1997
PubMed ID: 9393858
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
Zindy F, Soares H, Herzog KH, Morgan J, Sherr CJ, Roussel MF
Cell Growth Differ. 1997
PubMed ID: 9372237
Cooperative effects of INK4a and ras in melanoma susceptibility in vivo.
Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C, Horner JW, DePinho RA
Genes Dev. 1997
PubMed ID: 9353252
Germline mutations of the CDKN2 gene in UK melanoma families.
Harland M, Meloni R, Gruis N, Pinney E, Brookes S, Spurr NK, Frischauf AM, Bataille V, Peters G, Cuzick J, Selby P, Bishop DT, Bishop JN
Hum Mol Genet. 1997
PubMed ID: 9328469
Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status.
Palmero I, McConnell B, Parry D, Brookes S, Hara E, Bates S, Jat P, Peters G
Oncogene. 1997
PubMed ID: 9247303
Identification of CDK4 sequences involved in cyclin D1 and p16 binding.
Coleman KG, Wautlet BS, Morrissey D, Mulheron J, Sedman SA, Brinkley P, Price S, Webster KR
J Biol Chem. 1997
PubMed ID: 9228064
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.
Zindy F, Quelle DE, Roussel MF, Sherr CJ
Oncogene. 1997
PubMed ID: 9244355
Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma.
Platz A, Hansson J, Månsson-Brahme E, Lagerlof B, Linder S, Lundqvist E, Sevigny P, Inganäs M, Ringborg U
J Natl Cancer Inst. 1997
PubMed ID: 9168184
Low-frequency loss of heterozygosity in Moloney murine leukemia virus-induced tumors in BRAKF1/J mice.
Lander JK, Fan H
J Virol. 1997
PubMed ID: 9094671
Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.
Malumbres M, Pérez de Castro I, Santos J, Meléndez B, Mangues R, Serrano M, Pellicer A, Fernández-Piqueras J
Oncogene. 1997
PubMed ID: 9178896
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW
Cell. 1997
PubMed ID: 9054499
Frequent aberrant methylation of p16INK4a in primary rat lung tumors.
Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG, Belinsky SA
Mol Cell Biol. 1997
PubMed ID: 9032263
Cyclin-dependent kinase inhibitors: the age of crystals.
Pines J
Biochim Biophys Acta. 1997
PubMed ID: 9061010
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
Quelle DE, Cheng M, Ashmun RA, Sherr CJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9012842
Deletion and differential expression of p16INK4a in mouse lung tumors.
Belinsky SA, Swafford DS, Middleton SK, Kennedy CH, Tesfaigzi J
Carcinogenesis. 1997
PubMed ID: 9054597
Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene.
Herzog CR, You M
Mamm Genome. 1997
PubMed ID: 9021155
The 5'-flanking region of the E1 alpha form of the murine p16INK4a (MTS1) gene.
Soloff EV, Herzog CR, You M
Gene. 1996
PubMed ID: 8973369
Defective folding of mutant p16(INK4) proteins encoded by tumor-derived alleles.
Zhang B, Peng Z
J Biol Chem. 1996
PubMed ID: 8910511
Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.
Herzog CR, Soloff EV, McDoniels AL, Tyson FL, Malkinson AM, Haugen-Strano A, Wiseman RW, Anderson MW, You M
Oncogene. 1996
PubMed ID: 8934534
Prevalence of germ-line mutations in p16, p19ARF, and CDK4 in familial melanoma: analysis of a clinic-based population.
FitzGerald MG, Harkin DP, Silva-Arrieta S, MacDonald DJ, Lucchina LC, Unsal H, O'Neill E, Koh J, Finkelstein DM, Isselbacher KJ, Sober AJ, Haber DA
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8710906
Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism.
Tevelev A, Byeon IJ, Selby T, Ericson K, Kim HJ, Kraynov V, Tsai MD
Biochemistry. 1996
PubMed ID: 8755727
High frequency of aberrant p16(INK4A) expression in human breast cancer.
Geradts J, Wilson PA
Am J Pathol. 1996
PubMed ID: 8686738
Novel germline p16 mutation in familial malignant melanoma in southern Sweden.
Borg A, Johannsson U, Johannsson O, Häkansson S, Westerdahl J, Mäsbäck A, Olsson H, Ingvar C
Cancer Res. 1996
PubMed ID: 8653684
Allelotype analysis in mouse hepatocellular carcinomas; frequent homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in culture.
Miyasaka K, Fukui T, Kitagawa T
Biol Pharm Bull. 1996
PubMed ID: 8741575
Role of the INK4a locus in tumor suppression and cell mortality.
Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA
Cell. 1996
PubMed ID: 8620534
Homozygous deletion of mouse homolog of p16/CDKN2 gene on chromosome 4 in mouse liver epithelial cells in culture.
Miyasaka K, Kawauchi S
Biol Pharm Bull. 1996
PubMed ID: 8924897
Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
Hara E, Smith R, Parry D, Tahara H, Stone S, Peters G
Mol Cell Biol. 1996
PubMed ID: 8622687
Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A.
Fåhraeus R, Paramio JM, Ball KL, Laín S, Lane DP
Curr Biol. 1996
PubMed ID: 8805225
CDKN2 mutations in melanoma.
Dracopoli NC, Fountain JW
Cancer Surv. 1996
PubMed ID: 8783570
CDKN2A (p16INK4A) somatic and germline mutations.
Smith-Sørensen B, Hovig E
Hum Mutat. 1996
PubMed ID: 8723678
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.
Quelle DE, Zindy F, Ashmun RA, Sherr CJ
Cell. 1995
PubMed ID: 8521522
Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2).
Jiang P, Stone S, Wagner R, Wang S, Dayananth P, Kozak CA, Wold B, Kamb A
J Mol Evol. 1995
PubMed ID: 8587124
Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors.
Linardopoulos S, Street AJ, Quelle DE, Parry D, Peters G, Sherr CJ, Balmain A
Cancer Res. 1995
PubMed ID: 7585567
Mutations of the CDKN2/p16INK4 gene in Australian melanoma kindreds.
Walker GJ, Hussussian CJ, Flores JF, Glendening JM, Haluska FG, Dracopoli NC, Hayward NK, Fountain JW
Hum Mol Genet. 1995
PubMed ID: 8595405
Cloning and characterization of murine p16INK4a and p15INK4b genes.
Quelle DE, Ashmun RA, Hannon GJ, Rehberger PA, Trono D, Richter KH, Walker C, Beach D, Sherr CJ, Serrano M
Oncogene. 1995
PubMed ID: 7651726
Germline p16INK4A mutation and protein dysfunction in a family with inherited melanoma.
Liu L, Lassam NJ, Slingerland JM, Bailey D, Cole D, Jenkins R, Hogg D
Oncogene. 1995
PubMed ID: 7624155
Complex structure and regulation of the P16 (MTS1) locus.
Stone S, Jiang P, Dayananth P, Tavtigian SV, Katcher H, Parry D, Peters G, Kamb A
Cancer Res. 1995
PubMed ID: 7606716
A novel p16INK4A transcript.
Mao L, Merlo A, Bedi G, Shapiro GI, Edwards CD, Rollins BJ, Sidransky D
Cancer Res. 1995
PubMed ID: 7541708
A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.
Duro D, Bernard O, Della Valle V, Berger R, Larsen CJ
Oncogene. 1995
PubMed ID: 7624129
Growth suppression by p16ink4 requires functional retinoblastoma protein.
Medema RH, Herrera RE, Lam F, Weinberg RA
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7603984
Mutations associated with familial melanoma impair p16INK4 function.
Ranade K, Hussussian CJ, Sikorski RS, Varmus HE, Goldstein AM, Tucker MA, Serrano M, Hannon GJ, Beach D, Dracopoli NC
Nat Genet. 1995
PubMed ID: 7647780
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer.
Okamoto A, Hussain SP, Hagiwara K, Spillare EA, Rusin MR, Demetrick DJ, Serrano M, Hannon GJ, Shiseki M, Zariwala M
Cancer Res. 1995
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Identification of hepatocarcinogen-resistance genes in DBA/2 mice.
Lee GH, Bennett LM, Carabeo RA, Drinkwater NR
Genetics. 1995
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The MTS1 gene is frequently mutated in primary human esophageal tumors.
Zhou X, Tarmin L, Yin J, Jiang HY, Suzuki H, Rhyu MG, Abraham JM, Meltzer SJ
Oncogene. 1994
PubMed ID: 7970734
Mutations and altered expression of p16INK4 in human cancer.
Okamoto A, Demetrick DJ, Spillare EA, Hagiwara K, Hussain SP, Bennett WP, Forrester K, Gerwin B, Serrano M, Beach DH
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7972006
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus.
Kamb A, Shattuck-Eidens D, Eeles R, Liu Q, Gruis NA, Ding W, Hussey C, Tran T, Miki Y, Weaver-Feldhaus J
Nat Genet. 1994
PubMed ID: 7987388
Germline p16 mutations in familial melanoma.
Hussussian CJ, Struewing JP, Goldstein AM, Higgins PA, Ally DS, Sheahan MD, Clark WH, Tucker MA, Dracopoli NC
Nat Genet. 1994
PubMed ID: 7987387
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma.
Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE
Nat Genet. 1994
PubMed ID: 7726912
Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomas.
Hayashi N, Sugimoto Y, Tsuchiya E, Ogawa M, Nakamura Y
Biochem Biophys Res Commun. 1994
PubMed ID: 8060323
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers.
Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA
Nature. 1994
PubMed ID: 8152487
A cell cycle regulator potentially involved in genesis of many tumor types.
Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS, Johnson BE, Skolnick MH
Science. 1994
PubMed ID: 8153634
Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice.
Potter M, Mushinski EB, Wax JS, Hartley J, Mock BA
Cancer Res. 1994
PubMed ID: 8313388
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano M, Hannon GJ, Beach D
Nature. 1993
PubMed ID: 8259215

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1029	12578	25163
EnsEMBL Gene(s)	ENSG00000147889 LRG_11	ENSMUSG00000044303	ENSRNOG00000006664
Unigene	Hs.512599	Mm.4733	Rn.48717
Homologene	CDKN2A	Cdkn2a	Cdkn2a
OMIM	600160	N/A	N/A
GeneCards	CDKN2A	N/A	N/A
Beta Cell Genomics	DT.121147179 DT.444664 DT.95191887 DT.95191891 DT.95191893	DT.87047467 DT.91335312	N/A
Reactome	P42771	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1029	12578	25163

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CDKN2A	PDCD6	IntAct, BioGRID	empirical	17955473
CDKN2A	SAP25	IntAct, BioGRID	empirical	16449650
CDKN2A	HUWE1	HPRD, IntAct, BioGRID	empirical	15989956
CDKN2A	CDK4	HPRD, IntAct, MIPS, BioGRID, Reactome	empirical	9228064 15232106 17517622 17353931 17909018 17955473 10719365 8805225 15065884 10580009 8259215 9529249 8078588 8001816 8741839
CDKN2A	PSME3	BioGRID	empirical	17588519
CDKN2A	CDK6	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	9751050 17909018 17955473 15232106 8805225 11739795 8078588 8001816 8741839 8259215
CDKN2A	UBE4B	IntAct, BioGRID	empirical	17955473
CDKN2A	EIF1B	IntAct	empirical	17353931
CDKN2A	CDKN2A	HPRD	empirical	8755727 8910511
CDKN2A	CDKN2C	HPRD	empirical	8259215
CDKN2A	TUBB4B	IntAct, BioGRID	empirical	17955473
CDKN2A	DEAF1	IntAct	empirical	21988832
CDKN2A	KAT5	BioGRID	empirical	16705183
CDKN2A	MYL12A	IntAct, BioGRID	empirical	17955473
CDKN2A	RUVBL2	IntAct, BioGRID	empirical	17955473
CDKN2A	HAUS1	MINT	empirical	15232106
CDKN2A	DAXX	IntAct, BioGRID	empirical	18583933
CDKN2A	E2F1	HPRD	empirical	11314038
CDKN2A	E4F1	HPRD, BioGRID	empirical	12446718
CDKN2A	EEF2	IntAct, BioGRID	empirical	17955473
CDKN2A	EGR1	HPRD, MINT	empirical	19057511
CDKN2A	TUBB	IntAct, BioGRID	empirical	17955473 20360068
CDKN2A	EPB41	IntAct	empirical	17353931
CDKN2A	EPHA3	IntAct, BioGRID	empirical	17955473
CDKN2A	FKBP2	BioGRID	empirical	12606707
CDKN2A	MMRN1	IntAct, BioGRID	empirical	17955473
CDKN2A	ANKRD12	HPRD	empirical	16582619
CDKN2A	FN1	IntAct	empirical	21988832
CDKN2A	TDRD7	IntAct	empirical	21988832
CDKN2A	FTSJ1	IntAct	empirical	17353931
CDKN2A	GAPDH	IntAct, BioGRID	empirical	17955473
CDKN2A	GSPT1	HPRD	empirical	16582619
CDKN2A	SERTAD1	HPRD, BioGRID	empirical	10580009 15065884
CDKN2A	HIF1A	HPRD	empirical	11382768
CDKN2A	HLA-B	IntAct	empirical	17353931
CDKN2A	HNRNPA2B1	IntAct, BioGRID	empirical	17955473
CDKN2A	HNRNPC	IntAct	empirical	17955473
CDKN2A	HNRNPU	IntAct	empirical	21988832
CDKN2A	HSPA4	IntAct, BioGRID	empirical	17955473
CDKN2A	HSPA8	IntAct, BioGRID	empirical	17955473
CDKN2A	HSPA9	IntAct, BioGRID	empirical	17955473
CDKN2A	HSP90AA1	IntAct, BioGRID	empirical	17955473
CDKN2A	HSP90AB1	HPRD, IntAct, BioGRID	empirical	16582619 17955473
CDKN2A	ING1	BioGRID	empirical	19085961
CDKN2A	MCC	IntAct	empirical	17353931
CDKN2A	MCM2	HPRD, IntAct	empirical	15232106
CDKN2A	MCM5	HPRD, IntAct	empirical	15232106
CDKN2A	MCM6	IntAct, BioGRID	empirical	17955473
CDKN2A	MDM2	HPRD, MINT, IntAct, BioGRID	empirical	12085228 9529248 9529249 19166854 12740913 17373842 17909018 18583933 20832751 14612427 16107876 11718560 11223036 10822382 21133853 20395212 22120712
CDKN2A	MDM4	BioGRID	empirical	11297540
CDKN2A	MTR	IntAct	empirical	17955473
CDKN2A	MYC	HPRD	empirical	15361884
CDKN2A	MYCN	MINT	empirical	17289033
CDKN2A	NCL	HPRD	empirical	16582619
CDKN2A	ACLY	IntAct, BioGRID	empirical	17955473
CDKN2A	NPM1	MINT, IntAct, BioGRID	empirical	16957780 15989956 16679321 17277230
CDKN2A	ORC4	HPRD, IntAct	empirical	15232106
CDKN2A	ORC5	IntAct	empirical	15232106
CDKN2A	GMNN	HPRD, MINT, IntAct	empirical	15232106
CDKN2A	PCNA	IntAct, BioGRID	empirical	17955473
CDKN2A	ING4	BioGRID	empirical	18775696
CDKN2A	PML	IntAct	empirical	12740913
CDKN2A	RIN2	IntAct	empirical	17955473
CDKN2A	PPP1CA	IntAct	empirical	17274640
CDKN2A	PPP1CB	IntAct	empirical	17274640
CDKN2A	PPP1CC	IntAct	empirical	17274640
CDKN2A	MCM10	HPRD, IntAct	empirical	15232106
CDKN2A	CDKN2AIP	HPRD	empirical	12154087
CDKN2A	PRKCA	IntAct	empirical	21988832
CDKN2A	PSMC3	HPRD, BioGRID	empirical	14665636 17334400
CDKN2A	ACTR3B	IntAct	empirical	17353931
CDKN2A	ZNF410	HPRD	empirical	12370286
CDKN2A	PEX19	HPRD, IntAct	empirical	16582619 11259404
CDKN2A	CCND1	BioGRID	empirical	10580009
CDKN2A	ACTB	IntAct, BioGRID	empirical	17955473
CDKN2A	RPL11	BioGRID	empirical	14612427
CDKN2A	RPS7	HPRD	empirical	16582619
CDKN2A	SLC4A1	HPRD, MINT	empirical	15811326
CDKN2A	SMARCA4	BioGRID	empirical	19149898
CDKN2A	SUMO2	MINT	empirical	18259216
CDKN2A	SNRPA	IntAct, BioGRID	empirical	17955473
CDKN2A	SNRPB	IntAct, BioGRID	empirical	17955473
CDKN2A	SP1	BioGRID	empirical	21555589
CDKN2A	AURKA	IntAct, BioGRID	empirical	17353931
CDKN2A	ACTG1	IntAct	empirical	17955473
CDKN2A	TOP1	BioGRID	empirical	15361825
CDKN2A	TP53	IntAct, BioGRID	empirical	12740913 14612427 12446718 9529249 20395212
CDKN2A	TPI1	HPRD	empirical	16582619
CDKN2A	UBC	BioGRID	empirical	20208519 20395212 18781797 21139048
CDKN2A	UBE2A	HPRD, BioGRID	empirical	12640129
CDKN2A	UCHL1	BioGRID	empirical	20395212
CDKN2A	VHL	IntAct, BioGRID	empirical	17353931 21942715
CDKN2A	WRN	HPRD	empirical	15355988
CDKN2A	YY1	BioGRID	empirical	15210108
CDKN2A	ZNF227	HPRD	empirical	16582619
CDKN2A	TUBA1A	IntAct, BioGRID	empirical	17955473
CDKN2A	AHNAK	HPRD	empirical	16582619
CDKN2A	CRELD2	IntAct	empirical	21988832
CDKN2A	ALS2CR8	HPRD	empirical	12154087
CDKN2A	ZFP91	HPRD	empirical	16582619
CDKN2A	ACTN4	IntAct, BioGRID	empirical	17955473
CDKN2A	CDC7	HPRD, MINT, IntAct	empirical	15232106
CDKN2A	CDC45	HPRD, MINT, IntAct	empirical	15232106
CDKN2A	USP26	IntAct, BioGRID	empirical	17955473
CDKN2A	PPP1R9B	HPRD	empirical	11278317
CDKN2A	PLEKHA8	BioGRID	empirical	15107860
CDKN2A	TUBA1C	IntAct, BioGRID	empirical	17955473
CDKN2A	TBRG1	HPRD, BioGRID	empirical	16582619 17110379
CDKN2A	KIAA1984	HPRD	empirical	16582619
CDKN2A	TUBGCP6	IntAct	empirical	20360068
CDKN2A	LAMTOR3	BioGRID	empirical	20655927
CDKN2A	CCND2	BioGRID	empirical	15065884
CDKN2A	CCNG1	HPRD, BioGRID	empirical	12556559
CDKN2A	TRIP12	BioGRID	empirical	20208519
CDKN2A	ATG5	IntAct	empirical	17353931
CDKN2A	IKBKE	IntAct	empirical	17353931
CDKN2A	KIAA0101	BioGRID	empirical	21628590
CDKN2A	CDC5L	HPRD	empirical	15232106
CDKN2A	CDC6	HPRD, MINT, IntAct	empirical	15232106