Home LILRB2
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(Human) GRCh37 - chr19:54777675..54785039 (7.36 kb) View in Genome Browser
HaemAtlas Expression Table for LILRB2:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | no data | no data | no data | no data | no data | no data | |||||
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for LILRB2:The LILRB2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| LILRB2 | FCGR1A | HPRD | empirical | 9842885 |
| LILRB2 | HLA-A | HPRD | empirical | 12853576 9531263 |
| LILRB2 | HLA-B | HPRD | empirical | 12853576 9531263 |
| LILRB2 | HLA-C | HPRD | empirical | 12853576 |
| LILRB2 | HLA-F | HPRD | empirical | 11169396 |
| LILRB2 | HLA-G | HPRD | empirical | 12853576 15670976 9531263 10190906 |
| LILRB2 | PTPN6 | HPRD | empirical | 9842885 9531263 |
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Publications: 44
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HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding.
Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL
J Immunol. 2011
PubMed ID: 21270408
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LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence.
Ryu M, Chen Y, Qi J, Liu J, Fan Z, Nam G, Shi Y, Cheng H, Gao GF
PLoS One. 2011
PubMed ID: 21559424
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Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interacting with leukocyte immunoglobulin-like receptor B2.
Huang J, Burke P, Yang Y, Seiss K, Beamon J, Cung T, Toth I, Pereyra F, Lichterfeld M, Yu XG
J Virol. 2010
PubMed ID: 20702625
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Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.
Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF, Hauben E, Roncarolo MG
Blood. 2010
PubMed ID: 20448110
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Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes.
Jones DC, Roghanian A, Brown DP, Chang C, Allen RL, Trowsdale J, Young NT
Eur J Immunol. 2009
PubMed ID: 19658091
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Tryptophan deprivation induces inhibitory receptors ILT3 and ILT4 on dendritic cells favoring the induction of human CD4+CD25+ Foxp3+ T regulatory cells.
Brenk M, Scheler M, Koch S, Neumann J, Takikawa O, Häcker G, Bieber T, von Bubnoff D
J Immunol. 2009
PubMed ID: 19535644
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Ig-like transcript 4 inhibits lipid antigen presentation through direct CD1d interaction.
Li D, Wang L, Yu L, Freundt EC, Jin B, Screaton GR, Xu XN
J Immunol. 2009
PubMed ID: 19124746
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The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.
Brown DP, Jones DC, Anderson KJ, Lapaque N, Buerki RA, Trowsdale J, Allen RL
BMC Immunol. 2009
PubMed ID: 19860908
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Crystallization and preliminary X-ray analysis of the low-affinity complex between human leukocyte antigen-G (HLA-G) and leukocyte Ig-like receptor B2 (LILRB2).
Shiroishi M, Maenaka K
Protein Pept Lett. 2009
PubMed ID: 19356145
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Changes in the expression of the immunoglobulin-like transcript 3 (ILT3) and ILT4 receptors in renal allograft recipients: effect of donor and recipient aging.
Benito MJ, Lopez-Hoyos M, Fernandez-Fresnedo G, Ruiz JC, Benito A, San Segundo D, Gomez-Alamillo C, Arias M
Transplant Proc. 2008
PubMed ID: 19010139
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Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T
J Immunol. 2008
PubMed ID: 18802077
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Novel HLA-G-binding leukocyte immunoglobulin-like receptor (LILR) expression patterns in human placentas and umbilical cords.
McIntire RH, Sifers T, Platt JS, Ganacias KG, Langat DK, Hunt JS
Placenta. 2008
PubMed ID: 18538388
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Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6--STAT3 signaling pathway.
Liang S, Ristich V, Arase H, Dausset J, Carosella ED, Horuzsko A
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18550825
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Evidence for natural selection on leukocyte immunoglobulin-like receptors for HLA class I in Northeast Asians.
Hirayasu K, Ohashi J, Tanaka H, Kashiwase K, Ogawa A, Takanashi M, Satake M, Jia GJ, Chimge NO, Sideltseva EW, Tokunaga K, Yabe T
Am J Hum Genet. 2008
PubMed ID: 18439545
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Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.
Tedla N, Lee CW, Borges L, Geczy CL, Arm JP
J Leukoc Biol. 2008
PubMed ID: 17998301
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Central role of ILT3 in the T suppressor cell cascade.
Suciu-Foca N, Cortesini R
Cell Immunol. 2007
PubMed ID: 17923119
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Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.
Denoeud F, Kapranov P, Ucla C, Frankish A, Castelo R, Drenkow J, Lagarde J, Alioto T, Manzano C, Chrast J, Dike S, Wyss C, Henrichsen CN, Holroyd N, Dickson MC, Taylor R, Hance Z, Foissac S, Myers RM, Rogers J, Hubbard T, Harrow J, Guigó R, Gingeras TR, Antonarakis SE, Reymond A
Genome Res. 2007
PubMed ID: 17567994
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Cis binding between inhibitory receptors and MHC class I can regulate mast cell activation.
Masuda A, Nakamura A, Maeda T, Sakamoto Y, Takai T
J Exp Med. 2007
PubMed ID: 17420263
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Soluble HLA-G and HLA-G1 expressing antigen-presenting cells inhibit T-cell alloproliferation through ILT-2/ILT-4/FasL-mediated pathways.
Naji A, Durrbach A, Carosella ED, Rouas-Freiss N
Hum Immunol. 2007
PubMed ID: 17400057
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Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d).
Shiroishi M, Kuroki K, Rasubala L, Tsumoto K, Kumagai I, Kurimoto E, Kato K, Kohda D, Maenaka K
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17056715
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Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.
Shiroishi M, Kuroki K, Ose T, Rasubala L, Shiratori I, Arase H, Tsumoto K, Kumagai I, Kohda D, Maenaka K
J Biol Chem. 2006
PubMed ID: 16455647
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HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.
LeMaoult J, Zafaranloo K, Le Danff C, Carosella ED
FASEB J. 2005
PubMed ID: 15670976
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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The LILR family: modulators of innate and adaptive immune pathways in health and disease.
Brown D, Trowsdale J, Allen R
Tissue Antigens. 2004
PubMed ID: 15304001
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Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4.
Papanikolaou NA, Vasilescu ER, Suciu-Foca N
Hum Immunol. 2004
PubMed ID: 15301858
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The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
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Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d) expression on dendritic cells resulting in T cell hyporesponsiveness in vitro.
Beinhauer BG, McBride JM, Graf P, Pursch E, Bongers M, Rogy M, Korthauer U, de Vries JE, Aversa G, Jung T
Eur J Immunol. 2004
PubMed ID: 14971032
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Transcriptional regulation of ILT family receptors.
Nakajima H, Asai A, Okada A, Ping L, Hamajima F, Sata T, Isobe K
J Immunol. 2003
PubMed ID: 14662864
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Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.
Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, Allan DS, Makadzange A, Rowland-Jones S, Willcox B, Jones EY, van der Merwe PA, Kumagai I, Maenaka K
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12853576
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18.
Willcox BE, Thomas LM, Chapman TL, Heikema AP, West AP, Bjorkman PJ
BMC Struct Biol. 2002
PubMed ID: 12390682
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Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4.
Chang CC, Ciubotariu R, Manavalan JS, Yuan J, Colovai AI, Piazza F, Lederman S, Colonna M, Cortesini R, Dalla-Favera R, Suciu-Foca N
Nat Immunol. 2002
PubMed ID: 11875462
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Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex.
Young NT, Canavez F, Uhrberg M, Shum BP, Parham P
Immunogenetics. 2001
PubMed ID: 11491530
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Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, van der Merwe PA, McMichael AJ, Bell JI, Powis SH, O'Callaghan CA
Eur J Immunol. 2000
PubMed ID: 11169396
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Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells.
Allan DS, Colonna M, Lanier LL, Churakova TD, Abrams JS, Ellis SA, McMichael AJ, Braud VM
J Exp Med. 1999
PubMed ID: 10190906
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The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.
Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L
Eur J Immunol. 1998
PubMed ID: 9842885
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Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules.
Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, Dunbar R, Ogg GS, Cerundolo V, Rolink A
J Immunol. 1998
PubMed ID: 9531263
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A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.
Borges L, Hsu ML, Fanger N, Kubin M, Cosman D
J Immunol. 1997
PubMed ID: 9548455
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A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.
Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M
J Exp Med. 1997
PubMed ID: 9382880
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Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
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A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors.
Wagtmann N, Rojo S, Eichler E, Mohrenweiser H, Long EO
Curr Biol. 1997
PubMed ID: 9259559
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A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing.
Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M
J Exp Med. 1997
PubMed ID: 9151699
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Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.
Samaridis J, Colonna M
Eur J Immunol. 1997
PubMed ID: 9079806
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Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
No mouse phenotype links available for this gene.
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