CDK9

Summary Top Help

Gene Description:

cyclin-dependent kinase 9 (CDC2-related kinase); cyclin-dependent kinase 9

Synonyms:

C-2k, TAK, CTK1, CDC2L4, CDK9, Cdk9, PITALRE

Orthologs:

Human CDK9 (protein-coding), Mouse Cdk9 (protein-coding), Rat Cdk9 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr9:130547958..130553066 (5.11 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:32561302..32568596 (7.29 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:11672861..11677709 (4.85 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CDK9:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CDK9:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 9

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 31

KEGG Network: None available

Biocarta: None available

Reactome: 9
Elongation arrest and recovery	REACT_1892
Formation and Maturation of mRNA Transcript	REACT_2039
Formation of RNA Pol II elongation complex	REACT_1845
Gene Expression	REACT_71
Pausing and recovery of elongation	REACT_769
RNA Polymerase II Pre-transcription Events	REACT_22107
RNA Polymerase II Transcription	REACT_1366
RNA Polymerase II Transcription Elongation	REACT_833
Transcription	REACT_1788

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 31
Nucleotide binding	GO:0000166
DNA binding	GO:0003677
Protein kinase activity	GO:0004672
Cyclin-dependent protein kinase activity	GO:0004693
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Nucleolus	GO:0005730
Cytoplasm	GO:0005737
Regulation of DNA repair	GO:0006282
Regulation of transcription, DNA-dependent	GO:0006355
Transcription from RNA polymerase II promoter	GO:0006366
Transcription initiation from RNA polymerase II promoter	GO:0006367
Transcription elongation from RNA polymerase II promoter	GO:0006368
Protein phosphorylation	GO:0006468
Cell cycle	GO:0007049
Transcription elongation factor complex	GO:0008023
Cell proliferation	GO:0008283
RNA polymerase II carboxy-terminal domain kinase activity	GO:0008353
Gene expression	GO:0010467
Viral reproduction	GO:0016032
PML body	GO:0016605
SnRNA binding	GO:0017069
Regulation of histone modification	GO:0031056
Replication fork arrest	GO:0043111
Intracellular membrane-bounded organelle	GO:0043231
Transcription regulatory region DNA binding	GO:0044212
Positive regulation of viral transcription	GO:0050434
Negative regulation of cell cycle arrest	GO:0071157
Cellular response to cytokine stimulus	GO:0071345

Publications from PubMed Top Help

Publications: 272

CDKI-71, a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol.
Liu X, Shi S, Lam F, Pepper C, Fischer PM, Wang S
Int J Cancer. 2012
PubMed ID: 21484792
Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway.
Ramakrishnan R, Rice AP
J Cell Physiol. 2012
PubMed ID: 21448926
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.
Žumer K, Plemenitaš A, Saksela K, Peterlin BM
Nucleic Acids Res. 2011
PubMed ID: 21724609
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Biswas D, Milne TA, Basrur V, Kim J, Elenitoba-Johnson KS, Allis CD, Roeder RG
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21896721
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
Khan SZ, Mitra D
J Biol Chem. 2011
PubMed ID: 21555514
Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1.
Feichtinger S, Stamminger T, Müller R, Graf L, Klebl B, Eickhoff J, Marschall M
J Gen Virol. 2011
PubMed ID: 21450947
Cyclin-dependent kinase inhibitor, P276-00 induces apoptosis in multiple myeloma cells by inhibition of Cdk9-T1 and RNA polymerase II-dependent transcription.
Manohar SM, Rathos MJ, Sonawane V, Rao SV, Joshi KS
Leuk Res. 2011
PubMed ID: 21216463
Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.
Cojocaru M, Bouchard A, Cloutier P, Cooper JJ, Varzavand K, Price DH, Coulombe B
J Biol Chem. 2011
PubMed ID: 21127351
The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
Oqani RK, Kim HR, Diao YF, Park CS, Jin DI
BMC Dev Biol. 2011
PubMed ID: 21639898
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175.
Ammosova T, Obukhov Y, Kotelkin A, Breuer D, Beullens M, Gordeuk VR, Bollen M, Nekhai S
PLoS One. 2011
PubMed ID: 21533037
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
A role for CDK9-cyclin K in maintaining genome integrity.
Yu DS, Cortez D
Cell Cycle. 2011
PubMed ID: 21200140
The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
Benedikt A, Baltruschat S, Scholz B, Bursen A, Arrey TN, Meyer B, Varagnolo L, Müller AM, Karas M, Dingermann T, Marschalek R
Leukemia. 2011
PubMed ID: 21030982
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia.
Monroe SC, Jo SY, Sanders DS, Basrur V, Elenitoba-Johnson KS, Slany RK, Hess JL
Exp Hematol. 2011
PubMed ID: 20854876
Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.
Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K
J Cell Physiol. 2011
PubMed ID: 20665673
CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
Gordon V, Bhadel S, Wunderlich W, Zhang J, Ficarro SB, Mollah SA, Shabanowitz J, Hunt DF, Xenarios I, Hahn WC, Conaway M, Carey MF, Gioeli D
Mol Endocrinol. 2010
PubMed ID: 20980437
Cyclin T1/CDK9 interacts with influenza A virus polymerase and facilitates its association with cellular RNA polymerase II.
Zhang J, Li G, Ye X
J Virol. 2010
PubMed ID: 20943989
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.
Yu DS, Zhao R, Hsu EL, Cayer J, Ye F, Guo Y, Shyr Y, Cortez D
EMBO Rep. 2010
PubMed ID: 20930849
Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8).
Li LL, Hu ST, Wang SH, Lee HH, Wang YT, Ping YH
Cell Microbiol. 2010
PubMed ID: 20618343
Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation.
Song SH, Kim A, Ragoczy T, Bender MA, Groudine M, Dean A
Blood. 2010
PubMed ID: 20570862
IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.
Smallie T, Ricchetti G, Horwood NJ, Feldmann M, Clark AR, Williams LM
J Exp Med. 2010
PubMed ID: 20805562
Halogen bonds form the basis for selective P-TEFb inhibition by DRB.
Baumli S, Endicott JA, Johnson LN
Chem Biol. 2010
PubMed ID: 20851342
TIF1gamma controls erythroid cell fate by regulating transcription elongation.
Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI
Cell. 2010
PubMed ID: 20603019
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
Dow EC, Liu H, Rice AP
J Cell Physiol. 2010
PubMed ID: 20201073
Pharmacological targeting of CDK9 in cardiac hypertrophy.
Krystof V, Chamrád I, Jorda R, Kohoutek J
Med Res Rev. 2010
PubMed ID: 19757441
55K isoform of CDK9 associates with Ku70 and is involved in DNA repair.
Liu H, Herrmann CH, Chiang K, Sung TL, Moon SH, Donehower LA, Rice AP
Biochem Biophys Res Commun. 2010
PubMed ID: 20493174
Crystal structure of HIV-1 Tat complexed with human P-TEFb.
Tahirov TH, Babayeva ND, Varzavand K, Cooper JJ, Sedore SC, Price DH
Nature. 2010
PubMed ID: 20535204
Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9.
Pirngruber J, Johnsen SA
Oncogene. 2010
PubMed ID: 20190802
Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation.
Belakavadi M, Fondell JD
Mol Cell Biol. 2010
PubMed ID: 20231357
c-Myc regulates transcriptional pause release.
Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA
Cell. 2010
PubMed ID: 20434984
CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells.
Bettayeb K, Baunbæk D, Delehouze C, Loaëc N, Hole AJ, Baumli S, Endicott JA, Douc-Rasy S, Bénard J, Oumata N, Galons H, Meijer L
Genes Cancer. 2010
PubMed ID: 21779453
Characterization of the DOT1L network: implications of diverse roles for DOT1L.
Park G, Gong Z, Chen J, Kim JE
Protein J. 2010
PubMed ID: 20431927
Induction of monocyte chemoattractant protein-1 (MCP-1/CCL2) gene expression by human immunodeficiency virus-1 Tat in human astrocytes is CDK9 dependent.
Khiati A, Chaloin O, Muller S, Tardieu M, Horellou P
J Neurovirol. 2010
PubMed ID: 20370601
Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K
J Biol Chem. 2010
PubMed ID: 20081228
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML
Cancer Cell. 2010
PubMed ID: 20153263
Streamlined analysis schema for high-throughput identification of endogenous protein complexes.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133760
Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.
Muniz L, Egloff S, Ughy B, Jády BE, Kiss T
PLoS Pathog. 2010
PubMed ID: 20976203
The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.
Giannone RJ, McDonald HW, Hurst GB, Shen RF, Wang Y, Liu Y
PLoS One. 2010
PubMed ID: 20811636
Selective control of gene expression by CDK9 in human cells.
Garriga J, Xie H, Obradovic Z, Graña X
J Cell Physiol. 2010
PubMed ID: 19780058
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4(+) T lymphocytes.
Ramakrishnan R, Dow EC, Rice AP
J Leukoc Biol. 2009
PubMed ID: 19741158
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing.
Pirngruber J, Shchebet A, Johnsen SA
Cell Cycle. 2009
PubMed ID: 19844166
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J
Cell. 2009
PubMed ID: 19914168
Misguided transcriptional elongation causes mixed lineage leukemia.
Mueller D, García-Cuéllar MP, Bach C, Buhl S, Maethner E, Slany RK
PLoS Biol. 2009
PubMed ID: 19956800
SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.
Brès V, Yoshida T, Pickle L, Jones KA
Mol Cell. 2009
PubMed ID: 19818711
Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation.
Zippo A, Serafini R, Rocchigiani M, Pennacchini S, Krepelova A, Oliviero S
Cell. 2009
PubMed ID: 19766566
CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.
Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman RD, Eick D, Aylon Y, Oren M, Johnsen SA
EMBO Rep. 2009
PubMed ID: 19575011
MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells.
Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, Wada H, Kita T, Shimatsu A, Hasegawa K
Circ J. 2009
PubMed ID: 19521018
Ubiquitination of HEXIM1 by HDM2.
Lau J, Lew QJ, Diribarne G, Michels AA, Dey A, Bensaude O, Lane DP, Chao SH
Cell Cycle. 2009
PubMed ID: 19617712
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
Cyclin T2 is essential for mouse embryogenesis.
Kohoutek J, Li Q, Blazek D, Luo Z, Jiang H, Peterlin BM
Mol Cell Biol. 2009
PubMed ID: 19364821
Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.
Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M
EMBO J. 2009
PubMed ID: 19387490
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Expression of cell cycle molecules in human azoospermic testes]
Yang B, Yuan JL, Gao XK, Qin WJ, Liu F, Shao C, Liu HL, Kang FX
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19426592
Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity.
Rechter S, Scott GM, Eickhoff J, Zielke K, Auerochs S, Müller R, Stamminger T, Rawlinson WD, Marschall M
J Biol Chem. 2009
PubMed ID: 19179338
Cell cycle, CDKs and cancer: a changing paradigm.
Malumbres M, Barbacid M
Nat Rev Cancer. 2009
PubMed ID: 19238148
Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN
J Virol. 2009
PubMed ID: 18971272
Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation.
Elagib KE, Mihaylov IS, Delehanty LL, Bullock GC, Ouma KD, Caronia JF, Gonias SL, Goldfarb AN
Blood. 2008
PubMed ID: 18780834
Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases.
Romano G, Giordano A
Cell Cycle. 2008
PubMed ID: 19029809
Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop.
Wang Y, Dow EC, Liang YY, Ramakrishnan R, Liu H, Sung TL, Lin X, Rice AP
J Biol Chem. 2008
PubMed ID: 18829461
Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1.
Durand LO, Roizman B
J Virol. 2008
PubMed ID: 18753202
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2.
Nojima M, Huang Y, Tyagi M, Kao HY, Fujinaga K
J Mol Biol. 2008
PubMed ID: 18662700
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Expanding role of cyclin dependent kinases in cytokine inducible gene expression.
Brasier AR
Cell Cycle. 2008
PubMed ID: 18728388
Cdk9-55: a new player in muscle regeneration.
Giacinti C, Musarò A, De Falco G, Jourdan I, Molinaro M, Bagella L, Simone C, Giordano A
J Cell Physiol. 2008
PubMed ID: 18546201
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
Baumli S, Lolli G, Lowe ED, Troiani S, Rusconi L, Bullock AN, Debreczeni JE, Knapp S, Johnson LN
EMBO J. 2008
PubMed ID: 18566585
Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology.
Wang S, Fischer PM
Trends Pharmacol Sci. 2008
PubMed ID: 18423896
RelA Ser276 phosphorylation is required for activation of a subset of NF-kappaB-dependent genes by recruiting cyclin-dependent kinase 9/cyclin T1 complexes.
Nowak DE, Tian B, Jamaluddin M, Boldogh I, Vergara LA, Choudhary S, Brasier AR
Mol Cell Biol. 2008
PubMed ID: 18362169
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
Chen R, Liu M, Li H, Xue Y, Ramey WN, He N, Ai N, Luo H, Zhu Y, Zhou N, Zhou Q
Genes Dev. 2008
PubMed ID: 18483222
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
Gegonne A, Weissman JD, Lu H, Zhou M, Dasgupta A, Ribble R, Brady JN, Singer DS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18391197
Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription.
Sabò A, Lusic M, Cereseto A, Giacca M
Mol Cell Biol. 2008
PubMed ID: 18250157
Cdk9/Cyclin T1 complex: a key player during the activation/differentiation process of normal lymphoid B cells.
De Falco G, Leucci E, Onnis A, Bellan C, Tigli C, Wirths S, Cerino G, Cocco M, Crupi D, De Luca A, Lanzavecchia A, Tosi P, Leoncini L, Giordano A
J Cell Physiol. 2008
PubMed ID: 18205180
Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9.
Montanuy I, Torremocha R, Hernández-Munain C, Suñé C
J Biol Chem. 2008
PubMed ID: 18218627
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
He N, Jahchan NS, Hong E, Li Q, Bayfield MA, Maraia RJ, Luo K, Zhou Q
Mol Cell. 2008
PubMed ID: 18249148
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells.
Hanyu-Nakamura K, Sonobe-Nojima H, Tanigawa A, Lasko P, Nakamura A
Nature. 2008
PubMed ID: 18200011
Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression.
Yang Z, He N, Zhou Q
Mol Cell Biol. 2008
PubMed ID: 18039861
Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation.
Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE, Rustgi AK
Mol Cell Biol. 2008
PubMed ID: 17998334
Kaposi's sarcoma-associated herpesvirus K-cyclin interacts with Cdk9 and stimulates Cdk9-mediated phosphorylation of p53 tumor suppressor.
Chang PC, Li M
J Virol. 2008
PubMed ID: 17942552
The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
Hou T, Ray S, Brasier AR
J Biol Chem. 2007
PubMed ID: 17956865
AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.
Oven I, Brdicková N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM
Mol Cell Biol. 2007
PubMed ID: 17938200
The role of the Cdk9/Cyclin T1 complex in T cell differentiation.
Leucci E, De Falco G, Onnis A, Cerino G, Cocco M, Luzzi A, Crupi D, Tigli C, Bellan C, Tosi P, Leoncini L, Giordano A
J Cell Physiol. 2007
PubMed ID: 17352406
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
Differential regulation of NF-kappaB by elongation factors is determined by core promoter type.
Amir-Zilberstein L, Ainbinder E, Toube L, Yamaguchi Y, Handa H, Dikstein R
Mol Cell Biol. 2007
PubMed ID: 17502349
Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.
Espinoza-Derout J, Wagner M, Shahmiri K, Mascareno E, Chaqour B, Siddiqui MA
Cardiovasc Res. 2007
PubMed ID: 17459355
Regulation of P-TEFb elongation complex activity by CDK9 acetylation.
Fu J, Yoon HG, Qin J, Wong J
Mol Cell Biol. 2007
PubMed ID: 17452463
P-TEFb is a crucial co-factor for Myc transactivation.
Gargano B, Amente S, Majello B, Lania L
Cell Cycle. 2007
PubMed ID: 17700062
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
Takezawa S, Yokoyama A, Okada M, Fujiki R, Iriyama A, Yanagi Y, Ito H, Takada I, Kishimoto M, Miyajima A, Takeyama K, Umesono K, Kitagawa H, Kato S
EMBO J. 2007
PubMed ID: 17255935
Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.
Cannavo E, Gerrits B, Marra G, Schlapbach R, Jiricny J
J Biol Chem. 2007
PubMed ID: 17148452
C/EBPbeta regulates human immunodeficiency virus 1 gene expression through its association with cdk9.
Mameli G, Deshmane SL, Ghafouri M, Cui J, Simbiri K, Khalili K, Mukerjee R, Dolei A, Amini S, Sawaya BE
J Gen Virol. 2007
PubMed ID: 17251582
The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.
Yoh SM, Cho H, Pickle L, Evans RM, Jones KA
Genes Dev. 2007
PubMed ID: 17234882
Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells.
Simone C, Giordano A
Cell Death Differ. 2007
PubMed ID: 16841087
Novel binding partners of Ldb1 are required for haematopoietic development.
Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, Gering M, Patient R, Hostert A, Grosveld F
Development. 2006
PubMed ID: 17108004
Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation.
He N, Pezda AC, Zhou Q
Mol Cell Biol. 2006
PubMed ID: 16980611
The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention.
Stevens M, De Clercq E, Balzarini J
Med Res Rev. 2006
PubMed ID: 16838299
Cdk9 phosphorylates p53 on serine 392 independently of CKII.
Claudio PP, Cui J, Ghafouri M, Mariano C, White MK, Safak M, Sheffield JB, Giordano A, Khalili K, Amini S, Sawaya BE
J Cell Physiol. 2006
PubMed ID: 16741955
Controlling the elongation phase of transcription with P-TEFb.
Peterlin BM, Price DH
Mol Cell. 2006
PubMed ID: 16885020
The BRCA1 COOH-terminal region acts as an RNA polymerase II carboxyl-terminal domain kinase inhibitor that modulates p21WAF1/CIP1 expression.
Moisan A, Gaudreau L
J Biol Chem. 2006
PubMed ID: 16735508
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter.
Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E
J Biol Chem. 2006
PubMed ID: 16687403
Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis.
Iankova I, Petersen RK, Annicotte JS, Chavey C, Hansen JB, Kratchmarova I, Sarruf D, Benkirane M, Kristiansen K, Fajas L
Mol Endocrinol. 2006
PubMed ID: 16484339
Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter.
Tréand C, du Chéné I, Brès V, Kiernan R, Benarous R, Benkirane M, Emiliani S
EMBO J. 2006
PubMed ID: 16601680
CDK9 phosphorylates p53 on serine residues 33, 315 and 392.
Radhakrishnan SK, Gartel AL
Cell Cycle. 2006
PubMed ID: 16552184
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
The multiple functions of HIV-1 Tat: proliferation versus apoptosis.
Peruzzi F
Front Biosci. 2006
PubMed ID: 16146763
Heat shock protein 40 is necessary for human immunodeficiency virus-1 Nef-mediated enhancement of viral gene expression and replication.
Kumar M, Mitra D
J Biol Chem. 2005
PubMed ID: 16179353
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation.
Barboric M, Zhang F, Besenicar M, Plemenitas A, Peterlin BM
J Virol. 2005
PubMed ID: 16103164
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K
Mol Cell. 2005
PubMed ID: 16109376
Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186.
Li Q, Price JP, Byers SA, Cheng D, Peng J, Price DH
J Biol Chem. 2005
PubMed ID: 15965233
Regulation of human immunodeficiency virus type 1 gene expression by clade-specific Tat proteins.
Desfosses Y, Solis M, Sun Q, Grandvaux N, Van Lint C, Burny A, Gatignol A, Wainberg MA, Lin R, Hiscott J
J Virol. 2005
PubMed ID: 15994812
A review of HIV-1 Tat protein biological effects.
Pugliese A, Vidotto V, Beltramo T, Petrini S, Torre D
Cell Biochem Funct. 2005
PubMed ID: 15473004
The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
Durand LO, Advani SJ, Poon AP, Roizman B
J Virol. 2005
PubMed ID: 15890914
A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat.
Brès V, Gomes N, Pickle L, Jones KA
Genes Dev. 2005
PubMed ID: 15905409
HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.
Byers SA, Price JP, Cooper JJ, Li Q, Price DH
J Biol Chem. 2005
PubMed ID: 15713662
Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription.
Yik JH, Chen R, Pezda AC, Zhou Q
J Biol Chem. 2005
PubMed ID: 15713661
HIV-1 tat protein and cell proliferation and survival: a brief review.
Gibellini D, Vitone F, Schiavone P, Re MC
New Microbiol. 2005
PubMed ID: 16035254
Differential localization and expression of the Cdk9 42k and 55k isoforms.
Liu H, Herrmann CH
J Cell Physiol. 2005
PubMed ID: 15452830
Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors.
De Falco G, Bellan C, D'Amuri A, Angeloni G, Leucci E, Giordano A, Leoncini L
Cancer Biol Ther. 2005
PubMed ID: 15753651
A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation.
Barboric M, Peterlin BM
PLoS Biol. 2005
PubMed ID: 15719065
Cyclin-dependent kinase 9 is required for tumor necrosis factor-alpha-stimulated matrix metalloproteinase-9 expression in human lung adenocarcinoma cells.
Shan B, Zhuo Y, Chin D, Morris CA, Morris GF, Lasky JA
J Biol Chem. 2005
PubMed ID: 15528190
Poly(ADP-ribose) polymerase-1 is a negative regulator of HIV-1 transcription through competitive binding to TAR RNA with Tat.positive transcription elongation factor b (p-TEFb) complex.
Parent M, Yung TM, Rancourt A, Ho EL, Vispé S, Suzuki-Matsuda F, Uehara A, Wada T, Handa H, Satoh MS
J Biol Chem. 2005
PubMed ID: 15498776
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
HIV-1 TAR RNA: the target of molecular interactions between the virus and its host.
Bannwarth S, Gatignol A
Curr HIV Res. 2005
PubMed ID: 15638724
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.
Zhou M, Deng L, Lacoste V, Park HU, Pumfery A, Kashanchi F, Brady JN, Kumar A
J Virol. 2004
PubMed ID: 15564463
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Fryer CJ, White JB, Jones KA
Mol Cell. 2004
PubMed ID: 15546612
Cyclin-dependent kinase-9: an RNAPII kinase at the nexus of cardiac growth and death cascades.
Sano M, Schneider MD
Circ Res. 2004
PubMed ID: 15514168
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene.
Giraud S, Hurlstone A, Avril S, Coqueret O
Oncogene. 2004
PubMed ID: 15286705
Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure.
Sano M, Wang SC, Shirai M, Scaglia F, Xie M, Sakai S, Tanaka T, Kulkarni PA, Barger PM, Youker KA, Taffet GE, Hamamori Y, Michael LH, Craigen WJ, Schneider MD
EMBO J. 2004
PubMed ID: 15297879
HIV-1 infection and regulation of Tat function in macrophages.
Liou LY, Herrmann CH, Rice AP
Int J Biochem Cell Biol. 2004
PubMed ID: 15183343
BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II.
Cabart P, Chew HK, Murphy S
Oncogene. 2004
PubMed ID: 15107825
Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.
Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O
EMBO J. 2004
PubMed ID: 15201869
A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb.
Yik JH, Chen R, Pezda AC, Samford CS, Zhou Q
Mol Cell Biol. 2004
PubMed ID: 15169877
DNA sequence and analysis of human chromosome 9.
Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blöcker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I
Nature. 2004
PubMed ID: 15164053
Multiple actions of the human immunodeficiency virus type-1 Tat protein on microglial cell functions.
Minghetti L, Visentin S, Patrizio M, Franchini L, Ajmone-Cat MA, Levi G
Neurochem Res. 2004
PubMed ID: 15139295
Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II.
Pinhero R, Liaw P, Bertens K, Yankulov K
Eur J Biochem. 2004
PubMed ID: 15009212
Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1).
Chiu YL, Cao H, Jacque JM, Stevenson M, Rana TM
J Virol. 2004
PubMed ID: 14963154
Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.
Chen R, Yang Z, Zhou Q
J Biol Chem. 2004
PubMed ID: 14627702
Multiple effects of HIV-1 trans-activator protein on the pathogenesis of HIV-1 infection.
Huigen MC, Kamp W, Nottet HS
Eur J Clin Invest. 2004
PubMed ID: 14984439
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.
Fujinaga K, Irwin D, Huang Y, Taube R, Kurosu T, Peterlin BM
Mol Cell Biol. 2004
PubMed ID: 14701750
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.
Zhou M, Deng L, Kashanchi F, Brady JN, Shatkin AJ, Kumar A
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14569024
Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages.
Rice AP, Herrmann CH
Curr HIV Res. 2003
PubMed ID: 15049426
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q
Mol Cell. 2003
PubMed ID: 14580347
The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription.
Young TM, Wang Q, Pe'ery T, Mathews MB
Mol Cell Biol. 2003
PubMed ID: 12944466
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis.
Kanazawa S, Soucek L, Evan G, Okamoto T, Peterlin BM
Oncogene. 2003
PubMed ID: 12944920
CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.
Garriga J, Bhattacharya S, Calbó J, Marshall RM, Truongcao M, Haines DS, Graña X
Mol Cell Biol. 2003
PubMed ID: 12861003
Functional inactivation of Cdk9 through oligomerization chain reaction.
Napolitano G, Mazzocco A, Fraldi A, Majello B, Lania L
Oncogene. 2003
PubMed ID: 12894230
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.
Yeo M, Lin PS, Dahmus ME, Gill GN
J Biol Chem. 2003
PubMed ID: 12721286
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M
Mol Cell. 2003
PubMed ID: 12887902
MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.
Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O
Mol Cell Biol. 2003
PubMed ID: 12832472
Interaction of Sp1 transcription factor with HIV-1 Tat protein: looking for cellular partners.
Loregian A, Bortolozzo K, Boso S, Caputo A, Palù G
FEBS Lett. 2003
PubMed ID: 12753906
Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein.
Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, Beltram F, Giacca M
EMBO J. 2003
PubMed ID: 12727882
Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.
Kwak YT, Guo J, Prajapati S, Park KJ, Surabhi RM, Miller B, Gehrig P, Gaynor RB
Mol Cell. 2003
PubMed ID: 12718890
A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.
Zhang F, Barboric M, Blackwell TK, Peterlin BM
Genes Dev. 2003
PubMed ID: 12651893
The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation.
Friedl EM, Lane WS, Erdjument-Bromage H, Tempst P, Reinberg D
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12591939
The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription.
Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T
Mol Cell Biol. 2003
PubMed ID: 12588988
Novel complexes of cyclin-dependent kinases and a cyclin-like protein from Arabidopsis thaliana with a function unrelated to cell division.
Barrôco RM, De Veylder L, Magyar Z, Engler G, Inzé D, Mironov V
Cell Mol Life Sci. 2003
PubMed ID: 12678503
The RNA polymerase II elongation complex.
Shilatifard A, Conaway RC, Conaway JW
Annu Rev Biochem. 2003
PubMed ID: 12676794
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Differential acetylation of Tat coordinates its interaction with the co-activators cyclin T1 and PCAF.
Brès V, Tagami H, Péloponèse JM, Loret E, Jeang KT, Nakatani Y, Emiliani S, Benkirane M, Kiernan RE
EMBO J. 2002
PubMed ID: 12486002
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression.
Fujinaga K, Irwin D, Geyer M, Peterlin BM
J Virol. 2002
PubMed ID: 12368330
Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function.
Liou LY, Herrmann CH, Rice AP
J Virol. 2002
PubMed ID: 12368300
Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines.
Falco GD, Neri LM, Falco MD, Bellan C, Yu Z, Luca AD, Leoncini L, Giordano A
Oncogene. 2002
PubMed ID: 12386808
Interplay between cdk9 and NF-kappaB factors determines the level of HIV-1 gene transcription in astrocytic cells.
Amini S, Clavo A, Nadraga Y, Giordano A, Khalili K, Sawaya BE
Oncogene. 2002
PubMed ID: 12173051
CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
Napolitano G, Licciardo P, Carbone R, Majello B, Lania L
J Cell Physiol. 2002
PubMed ID: 12115727
Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation.
Kim YK, Bourgeois CF, Isel C, Churcher MJ, Karn J
Mol Cell Biol. 2002
PubMed ID: 12052871
Physical interaction between pRb and cdk9/cyclinT2 complex.
Simone C, Bagella L, Bellan C, Giordano A
Oncogene. 2002
PubMed ID: 12037672
Activation of MyoD-dependent transcription by cdk9/cyclin T2.
Simone C, Stiegler P, Bagella L, Pucci B, Bellan C, De Falco G, De Luca A, Guanti G, Puri PL, Giordano A
Oncogene. 2002
PubMed ID: 12037670
P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.
Lin X, Taube R, Fujinaga K, Peterlin BM
J Biol Chem. 2002
PubMed ID: 11884399
MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein.
Estable MC, Naghavi MH, Kato H, Xiao H, Qin J, Vahlne A, Roeder RG
J Biomed Sci. 2002
PubMed ID: 12065898
A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.
Bharucha DC, Zhou M, Nekhai S, Brady JN, Shukla RR, Kumar A
Virology. 2002
PubMed ID: 12036313
Spt5 cooperates with human immunodeficiency virus type 1 Tat by preventing premature RNA release at terminator sequences.
Bourgeois CF, Kim YK, Churcher MJ, West MJ, Karn J
Mol Cell Biol. 2002
PubMed ID: 11809800
Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex.
Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP
J Biol Chem. 2002
PubMed ID: 11704662
Cyclin T1 expression is mediated by a complex and constitutively active promoter and does not limit human immunodeficiency virus type 1 Tat function in unstimulated primary lymphocytes.
Martin-Serrano J, Li K, Bieniasz PD
J Virol. 2002
PubMed ID: 11739686
c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism.
Eberhardy SR, Farnham PJ
J Biol Chem. 2001
PubMed ID: 11673469
Stimulatory effect of splicing factors on transcriptional elongation.
Fong YW, Zhou Q
Nature. 2001
PubMed ID: 11780068
Functional interaction between cyclin T1/cdk9 and Puralpha determines the level of TNFalpha promoter activation by Tat in glial cells.
Darbinian N, Sawaya BE, Khalili K, Jaffe N, Wortman B, Giordano A, Amini S
J Neuroimmunol. 2001
PubMed ID: 11730934
Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome.
Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, Nakayama Ki K, Benkirane M
Mol Cell Biol. 2001
PubMed ID: 11689688
Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines.
Ghose R, Liou LY, Herrmann CH, Rice AP
J Virol. 2001
PubMed ID: 11689614
TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription.
Zhou M, Nekhai S, Bharucha DC, Kumar A, Ge H, Price DH, Egly JM, Brady JN
J Biol Chem. 2001
PubMed ID: 11572868
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes.
Nguyen VT, Kiss T, Michels AA, Bensaude O
Nature. 2001
PubMed ID: 11713533
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription.
Yang Z, Zhu Q, Luo K, Zhou Q
Nature. 2001
PubMed ID: 11713532
Visualization of in vivo direct interaction between HIV-1 TAT and human cyclin T1 in specific subcellular compartments by fluorescence resonance energy transfer.
Marcello A, Cinelli RA, Ferrari A, Signorelli A, Tyagi M, Pellegrini V, Beltram F, Giacca M
J Biol Chem. 2001
PubMed ID: 11504720
The peptidyl-prolyl isomerase Pin1 interacts with hSpt5 phosphorylated by Cdk9.
Lavoie SB, Albert AL, Handa H, Vincent M, Bensaude O
J Mol Biol. 2001
PubMed ID: 11575923
Binding of phage-displayed HIV-1 Tat to TAR RNA in the presence of cyclin T1.
Jonas G, Hoffmann S, Willbold D
J Biomed Sci. 2001
PubMed ID: 11549886
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.
Barboric M, Nissen RM, Kanazawa S, Jabrane-Ferrat N, Peterlin BM
Mol Cell. 2001
PubMed ID: 11545735
Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.
Simmons A, Aluvihare V, McMichael A
Immunity. 2001
PubMed ID: 11420046
DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation.
Ping YH, Rana TM
J Biol Chem. 2001
PubMed ID: 11112772
Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
Kim JB, Sharp PA
J Biol Chem. 2001
PubMed ID: 11145967
Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.
Ramanathan Y, Rajpara SM, Reza SM, Lees E, Shuman S, Mathews MB, Pe'ery T
J Biol Chem. 2001
PubMed ID: 11278802
The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.
Herrmann CH, Mancini MA
J Cell Sci. 2001
PubMed ID: 11282025
Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation.
Lee DK, Duan HO, Chang C
J Biol Chem. 2001
PubMed ID: 11266437
Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator.
Marcello A, Zoppé M, Giacca M
IUBMB Life. 2001
PubMed ID: 11547919
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Antiapoptotic function of Cdk9 (TAK/P-TEFb) in U937 promonocytic cells.
Foskett SM, Ghose R, Tang DN, Lewis DE, Rice AP
J Virol. 2001
PubMed ID: 11152495
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
Biochem Biophys Res Commun. 2000
PubMed ID: 11118314
Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.
Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F
Virology. 2000
PubMed ID: 11080476
Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genome.
Sawaya BE, Khalili K, Gordon J, Taube R, Amini S
J Biol Chem. 2000
PubMed ID: 10931842
HIV-1 TAR RNA enhances the interaction between Tat and cyclin T1.
Zhang J, Tamilarasu N, Hwang S, Garber ME, Huq I, Jones KA, Rana TM
J Biol Chem. 2000
PubMed ID: 10944537
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in th
Suñé C, Goldstrohm AC, Peng J, Price DH, Garcia-Blanco MA
Virology. 2000
PubMed ID: 10964778
CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.
Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA
Mol Cell Biol. 2000
PubMed ID: 10958691
Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1.
Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, Spiegelman BM
Mol Cell. 2000
PubMed ID: 10983978
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter.
Fong YW, Zhou Q
Mol Cell Biol. 2000
PubMed ID: 10913173
Genomic organization and characterization of promoter function of the human CDK9 gene.
Liu H, Rice AP
Gene. 2000
PubMed ID: 10903437
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.
Zhou M, Halanski MA, Radonovich MF, Kashanchi F, Peng J, Price DH, Brady JN
Mol Cell Biol. 2000
PubMed ID: 10866664
FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.
Wada T, Orphanides G, Hasegawa J, Kim DK, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H
Mol Cell. 2000
PubMed ID: 10912001
Domains in the SPT5 protein that modulate its transcriptional regulatory properties.
Ivanov D, Kwak YT, Guo J, Gaynor RB
Mol Cell Biol. 2000
PubMed ID: 10757782
Genomic organization, promoter analysis, and chromosomal mapping of the mouse gene encoding Cdk9.
Bagella L, Stiegler P, De Luca A, Siracusa LD, Giordano A
J Cell Biochem. 2000
PubMed ID: 10797576
Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression.
Thébault S, Gachon F, Lemasson I, Devaux C, Mesnard JM
J Biol Chem. 2000
PubMed ID: 10671520
Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation.
De Falco G, Bagella L, Claudio PP, De Luca A, Fu Y, Calabretta B, Sala A, Giordano A
Oncogene. 2000
PubMed ID: 10656684
Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.
O'Keeffe B, Fong Y, Chen D, Zhou S, Zhou Q
J Biol Chem. 2000
PubMed ID: 10617616
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
Kanazawa S, Okamoto T, Peterlin BM
Immunity. 2000
PubMed ID: 10661406
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.
Fu TJ, Peng J, Lee G, Price DH, Flores O
J Biol Chem. 1999
PubMed ID: 10574912
Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression.
Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A
J Cell Biochem. 1999
PubMed ID: 10536359
HIV-1 tat transcriptional activity is regulated by acetylation.
Kiernan RE, Vanhulle C, Schiltz L, Adam E, Xiao H, Maudoux F, Calomme C, Burny A, Nakatani Y, Jeang KT, Benkirane M, Van Lint C
EMBO J. 1999
PubMed ID: 10545121
Tat-SF1 protein associates with RAP30 and human SPT5 proteins.
Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp PA
Mol Cell Biol. 1999
PubMed ID: 10454543
The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.
Napolitano G, Licciardo P, Gallo P, Majello B, Giordano A, Lania L
AIDS. 1999
PubMed ID: 10465067
Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo.
Majello B, Napolitano G, Giordano A, Lania L
Oncogene. 1999
PubMed ID: 10467404
Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation.
Isel C, Karn J
J Mol Biol. 1999
PubMed ID: 10438593
Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.
Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10393900
A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription.
Parada CA, Roeder RG
EMBO J. 1999
PubMed ID: 10393184
Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.
Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR
J Virol. 1999
PubMed ID: 10364329
Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate.
Ramanathan Y, Reza SM, Young TM, Mathews MB, Pe'ery T
J Virol. 1999
PubMed ID: 10364292
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication.
Flores O, Lee G, Kessler J, Miller M, Schlief W, Tomassini J, Hazuda D
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10377393
Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation.
Kwak YT, Ivanov D, Guo J, Nee E, Gaynor RB
J Mol Biol. 1999
PubMed ID: 10329126
Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation.
Ivanov D, Kwak YT, Nee E, Guo J, García-Martínez LF, Gaynor RB
J Mol Biol. 1999
PubMed ID: 10329125
Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase.
Chen D, Zhou Q
Mol Cell Biol. 1999
PubMed ID: 10082552
Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription.
Chen D, Fong Y, Zhou Q
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10077579
Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes.
Ping YH, Rana TM
J Biol Chem. 1999
PubMed ID: 10066804
Stimulation of Tat-associated kinase-independent transcriptional elongation from the human immunodeficiency virus type-1 long terminal repeat by a cellular enhancer.
West MJ, Karn J
EMBO J. 1999
PubMed ID: 10064603
Interactions between Tat and TAR and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b.
Wimmer J, Fujinaga K, Taube R, Cujec TP, Zhu Y, Peng J, Price DH, Peterlin BM
Virology. 1999
PubMed ID: 10049833
Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T.
Fujinaga K, Taube R, Wimmer J, Cujec TP, Peterlin BM
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9990016
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Upregulation of cyclin T1/CDK9 complexes during T cell activation.
Garriga J, Peng J, Parreño M, Price DH, Henderson EE, Graña X
Oncogene. 1998
PubMed ID: 9872325
Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.
Wada T, Takagi T, Yamaguchi Y, Watanabe D, Handa H
EMBO J. 1998
PubMed ID: 9857195
Binding of CDK9 to TRAF2.
MacLachlan TK, Sang N, De Luca A, Puri PL, Levrero M, Giordano A
J Cell Biochem. 1998
PubMed ID: 9827693
Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specificity of HIV-1 Tat.
Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR
EMBO J. 1998
PubMed ID: 9843510
Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines.
Herrmann CH, Carroll RG, Wei P, Jones KA, Rice AP
J Virol. 1998
PubMed ID: 9811724
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.
Garber ME, Wei P, KewalRamani VN, Mayall TP, Herrmann CH, Rice AP, Littman DR, Jones KA
Genes Dev. 1998
PubMed ID: 9832504
Cloning of murine CDK9/PITALRE and its tissue-specific expression in development.
Bagella L, MacLachlan TK, Buono RJ, Pisano MM, Giordano A, De Luca A
J Cell Physiol. 1998
PubMed ID: 9766517
The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.
Li XY, Green MR
Genes Dev. 1998
PubMed ID: 9765201
The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.
Fujinaga K, Cujec TP, Peng J, Garriga J, Price DH, Graña X, Peterlin BM
J Virol. 1998
PubMed ID: 9696809
Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages.
Zhou Q, Chen D, Pierstorff E, Luo K
EMBO J. 1998
PubMed ID: 9649438
Transcriptional control: Tat cofactors and transcriptional elongation.
Yankulov K, Bentley D
Curr Biol. 1998
PubMed ID: 9651670
PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo.
Gold MO, Yang X, Herrmann CH, Rice AP
J Virol. 1998
PubMed ID: 9557739
Identification of multiple cyclin subunits of human P-TEFb.
Peng J, Zhu Y, Milton JT, Price DH
Genes Dev. 1998
PubMed ID: 9499409
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.
Wei P, Garber ME, Fang SM, Fischer WH, Jones KA
Cell. 1998
PubMed ID: 9491887
Tat, Tat-associated kinase, and transcription.
Jeang KT
J Biomed Sci. 1998
PubMed ID: 9570510
HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA.
Garber ME, Wei P, Jones KA
Cold Spring Harb Symp Quant Biol. 1998
PubMed ID: 10384302
TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines.
Yang X, Gold MO, Tang DN, Lewis DE, Aguilar-Cordova E, Rice AP, Herrmann CH
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9356449
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.
Mancebo HS, Lee G, Flygare J, Tomassini J, Luu P, Zhu Y, Peng J, Blau C, Hazuda D, Price D, Flores O
Genes Dev. 1997
PubMed ID: 9334326
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro.
Zhu Y, Pe'ery T, Peng J, Ramanathan Y, Marshall N, Marshall T, Amendt B, Mathews MB, Price DH
Genes Dev. 1997
PubMed ID: 9334325
CDC2-related kinase PITALRE phosphorylates pRb exclusively on serine and is widely expressed in human tissues.
De Luca A, Esposito V, Baldi A, Claudio PP, Fu Y, Caputi M, Pisano MM, Baldi F, Giordano A
J Cell Physiol. 1997
PubMed ID: 9258347
Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.
Zhou Q, Sharp PA
Science. 1996
PubMed ID: 8849451
The CDC2-related kinase PITALRE is the catalytic subunit of active multimeric protein complexes.
Garriga J, Mayol X, Graña X
Biochem J. 1996
PubMed ID: 8870681
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function.
Yang X, Herrmann CH, Rice AP
J Virol. 1996
PubMed ID: 8676484
Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells.
Best JL, Presky DH, Swerlick RA, Burns DK, Chu W
Biochem Biophys Res Commun. 1995
PubMed ID: 7695608
Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor.
Herrmann CH, Rice AP
J Virol. 1995
PubMed ID: 7853496
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.
Graña X, De Luca A, Sang N, Fu Y, Claudio PP, Rosenblatt J, Morgan DO, Giordano A
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8170997

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1025	107951	362110
EnsEMBL Gene(s)	ENSG00000136807	ENSMUSG00000009555	ENSRNOG00000022586
Unigene	Hs.150423	Mm.27557	Rn.98228
Homologene	CDK9	Cdk9	Cdk9
OMIM	603251	N/A	N/A
GeneCards	CDK9	N/A	N/A
Beta Cell Genomics	DT.307654 DT.452362	DT.101735411 DT.533908 DT.55238959	N/A
Reactome	P50750	N/A	N/A
Plasma Peptide Atlas	ENSP00000362361	N/A	N/A
WikiGenes	1025	107951	362110

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Interactor	Interactor	Sources	Classification	Pubmed IDs
CDK9	NR2E3	HPRD, MINT, BioGRID	empirical	17255935
CDK9	TRIM28	BioGRID	empirical	17643375
CDK9	CTDSPL	HPRD	empirical	10617616 15009212 11278802 11145967 11572868 11884399 12052871
CDK9	CDK7	BioGRID	empirical	11145967
CDK9	HNRNPR	BioGRID	empirical	17643375
CDK9	CDK9	BioGRID	empirical	10958691 18971272 20603019 14580347
CDK9	TUBB4B	BioGRID	empirical	17643375
CDK9	SYNCRIP	BioGRID	empirical	17643375
CDK9	CCT4	BioGRID	empirical	17643375
CDK9	HEXIM1	HPRD, MINT	empirical	12832472 15201869 15169877 14580347 18483487
CDK9	ARID3B	BioGRID	empirical	17643375
CDK9	IGF2BP2	BioGRID	empirical	17643375
CDK9	CCT8	BioGRID	empirical	17643375
CDK9	RUVBL2	BioGRID	empirical	17643375
CDK9	HNRNPA0	BioGRID	empirical	17643375
CDK9	SUPT16H	IntAct, BioGRID	empirical	20603019
CDK9	SNRPD2P1	BioGRID	empirical	17643375
CDK9	HEXIM2	HPRD, BioGRID	empirical	15713662 15713661 17643375
CDK9	RN7SK	BioGRID	empirical	14580347
CDK9	CTD	BioGRID	empirical	14580347
CDK9	CSNK2B	BioGRID	empirical	17643375
CDK9	DDX5	BioGRID	empirical	17643375
CDK9	DTYMK	BioGRID	empirical	17643375
CDK9	EP300	BioGRID	empirical	20081228
CDK9	FKBP5	BioGRID	empirical	17643375
CDK9	DHX30	HPRD, MINT, BioGRID	empirical	17255935
CDK9	ELL2	IntAct	empirical	21729782
CDK9	SNW1	BioGRID	empirical	19818711
CDK9	CCT5	BioGRID	empirical	17643375
CDK9	ZC3H13	BioGRID	empirical	20133760
CDK9	MRPS27	BioGRID	empirical	17643375
CDK9	BRD4	BioGRID	empirical	16109376 16980611 18039861 17643375 19766566 21555454
CDK9	GATA4	BioGRID	empirical	20081228
CDK9	GATA6	BioGRID	empirical	20081228
CDK9	NUFIP1	BioGRID	empirical	15107825
CDK9	AFF4	HPRD, IntAct, BioGRID	empirical	12065898 20153263 21729782 17643375
CDK9	STK36	HPRD	empirical	9557739
CDK9	HTATSF1	HPRD	empirical	9649438
CDK9	GRN	HPRD, BioGRID	empirical	12588988
CDK9	GTF2F1	BioGRID	empirical	12591939
CDK9	MDFIC	BioGRID	empirical	12944466
CDK9	HNRNPA1	BioGRID	empirical	17643375
CDK9	HNRNPA2B1	BioGRID	empirical	17643375
CDK9	HNRNPD	BioGRID	empirical	17643375
CDK9	HNRNPH1	BioGRID	empirical	17643375
CDK9	HNRNPK	BioGRID	empirical	17643375
CDK9	HNRNPU	BioGRID	empirical	17643375
CDK9	HSPA1A	HPRD	empirical	10617616
CDK9	HSPA2	BioGRID	empirical	17643375
CDK9	HSPA5	BioGRID	empirical	17643375
CDK9	HSPA6	BioGRID	empirical	17643375
CDK9	HSP90AB1	BioGRID	empirical	17643375
CDK9	HSPD1	BioGRID	empirical	17643375
CDK9	IL6ST	HPRD, BioGRID	empirical	12386808
CDK9	ILF2	BioGRID	empirical	17643375
CDK9	AR	HPRD	empirical	11266437
CDK9	KPNA2	BioGRID	empirical	17643375
CDK9	SMAD1	BioGRID	empirical	19914168
CDK9	SMAD2	BioGRID	empirical	19914168
CDK9	SMAD3	BioGRID	empirical	19914168
CDK9	MAX	IntAct	empirical	20434984
CDK9	MDM2	BioGRID	empirical	19617712
CDK9	MLLT1	IntAct, BioGRID	empirical	20153263 21729782 19956800 20431927
CDK9	AFF1	IntAct, BioGRID	empirical	20153263 21729782 21030982
CDK9	MLLT3	IntAct, BioGRID	empirical	21729782 20431927 20854876
CDK9	MYBL2	HPRD, BioGRID	empirical	10656684
CDK9	MYC	IntAct, BioGRID	empirical	20434984 12944920 19818711 11673469 17700062
CDK9	NBN	HPRD	empirical	9258347 8170997 8870681
CDK9	NFKB1	HPRD	empirical	12173051
CDK9	YBX1	BioGRID	empirical	17643375
CDK9	PCBP2	BioGRID	empirical	17643375
CDK9	UBR5	BioGRID	empirical	21127351
CDK9	LARP7	MINT, BioGRID	empirical	18483487 17643375
CDK9	TRIM33	IntAct, BioGRID	empirical	20603019
CDK9	PIN1	HPRD	empirical	11575923
CDK9	PMS1	BioGRID	empirical	17148452
CDK9	POLR2A	HPRD, BioGRID	empirical	11575923 16735508 17234882 21030982 18391197 12591939
CDK9	ATR	BioGRID	empirical	20930849
CDK9	MED1	BioGRID	empirical	20133760
CDK9	CCDC87	BioGRID	empirical	17643375
CDK9	MAPK3	MINT	empirical	19935650
CDK9	MEPCE	BioGRID	empirical	17643375
CDK9	EXOSC5	BioGRID	empirical	17643375
CDK9	RB1	HPRD, BioGRID	empirical	9258347 8170997 8870681 12037672
CDK9	RBBP7	MINT	empirical	17255935
CDK9	RELA	HPRD, BioGRID	empirical	12173051
CDK9	RFC4	BioGRID	empirical	17643375
CDK9	ACTB	BioGRID	empirical	20081228
CDK9	RPS4X	BioGRID	empirical	17643375
CDK9	CLSPN	BioGRID	empirical	20930849
CDK9	RMND5B	IntAct	empirical	21988832
CDK9	SKP1	BioGRID	empirical	11689688
CDK9	SKP2	HPRD, BioGRID	empirical	12861003 11689688
CDK9	HLTF	IntAct	empirical	21988832
CDK9	STAT3	BioGRID	empirical	15286705
CDK9	SUPT5H	HPRD, BioGRID	empirical	11145967 11575923 10958691
CDK9	TAF7	BioGRID	empirical	18391197
CDK9	TAL1	IntAct, BioGRID	empirical	20603019
CDK9	TAT	BioGRID	empirical	16601680
CDK9	TCEA1	BioGRID	empirical	21127351
CDK9	TERF1	BioGRID	empirical	20811636
CDK9	TERF2	BioGRID	empirical	20811636
CDK9	TP53	HPRD, BioGRID	empirical	16552184 10656684
CDK9	TRAF2	HPRD	empirical	9827693
CDK9	CCT3	BioGRID	empirical	17643375
CDK9	UBC	BioGRID	empirical	21127351 21987572 21139048 21890473 21906983
CDK9	CDC73	BioGRID	empirical	17643375
CDK9	ELL3	IntAct	empirical	21729782
CDK9	MED28	BioGRID	empirical	20133760
CDK9	ELL	IntAct	empirical	21729782
CDK9	CDC7	IntAct	empirical	21988832
CDK9	ATRIP	BioGRID	empirical	20930849
CDK9	CUL1	HPRD, BioGRID	empirical	12861003 11689688
CDK9	EAF1	IntAct	empirical	21729782
CDK9	CASK	IntAct	empirical	21988832
CDK9	RUVBL1	BioGRID	empirical	17643375
CDK9	SERPINH1	HPRD	empirical	11572868
CDK9	CCNK	HPRD, BioGRID	empirical	11884399 10574912
CDK9	CDK5R1	HPRD	empirical	12037672
CDK9	BCL10	IntAct	empirical	21988832
CDK9	CCNT1	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	15528190 11689688 14627702 9872325 10617616 11145967 11713533 11713532 12894230 12115727 10465067 9499409 10958691 11282025 9491887 18483487 18566585 19914168 20153263 21729782 15107825 12944466 12832472 12588988 10656684 10574912 16980611 17643375 19818711 17700062 20081228 15546612 14580347 9356449
CDK9	CCNT2	HPRD, IntAct, BioGRID, Reactome, Sanger Interaction Map	empirical	9499409 10465067 11282025 21729782 17643375 15345047
CDK9	ZMYM6	HPRD	empirical	11282025 11884399
CDK9	TRIP12	BioGRID	empirical	17643375
CDK9	MED21	HPRD	empirical	9872325 11278802
CDK9	MED26	IntAct	empirical	21729782
CDK9	RBM39	BioGRID	empirical	17643375
CDK9	SART3	BioGRID	empirical	17643375
CDK9	MATR3	BioGRID	empirical	17643375
CDK9	CKAP5	BioGRID	empirical	17643375
CDK9	CDC34	HPRD, BioGRID	empirical	11689688