Home CDK7
|
Regions Overlapping this Feature:
Mouse: 1
Rat: 1
Linkage Regions: 1 Available
Other Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd14 | Mouse | chr13:25424067..120284312 | 94.86 | 733 | 1 no lod score |
Other Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm32 | Rat | chr2:30109071..79796790 | 49.69 | 199 |
(Human) GRCh37 - chr5:68530622..68573257 (42.63 kb) View in Genome Browser
(Mouse) NCBIM37 - chr13:101466979..101500897 (33.92 kb) View in Genome Browser
(Rat) RGSC3.4 - chr2:31500629..31525592 (24.96 kb) View in Genome Browser
HaemAtlas Expression Table for CDK7:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for CDK7:The CDK7 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| CDK7 | CDK2 | HPRD, BioGRID | empirical | 11113184 8692842 |
| CDK7 | CDK7 | HPRD | empirical | 9056480 |
| CDK7 | CDK9 | BioGRID | empirical | 11145967 |
| CDK7 | CCT2 | BioGRID | empirical | 17643375 |
| CDK7 | NEK6 | HPRD | empirical | 12023960 |
| CDK7 | RUVBL2 | BioGRID | empirical | 17643375 |
| CDK7 | CDC37 | BioGRID | empirical | 8666233 |
| CDK7 | CUX1 | BioGRID | empirical | 11584018 |
| CDK7 | E2F1 | HPRD | empirical | 10428966 |
| CDK7 | ERCC2 | HPRD, BioGRID | empirical | 11445587 8692841 |
| CDK7 | ERCC3 | HPRD, BioGRID | empirical | 9130708 15220921 8521393 17643375 8692841 |
| CDK7 | ERCC5 | BioGRID | empirical | 17643375 |
| CDK7 | ESR1 | HPRD, BioGRID | empirical | 15461668 10949034 |
| CDK7 | GTF2H1 | HPRD, BioGRID | empirical | 9130708 7533895 8521393 9852112 8692841 |
| CDK7 | GTF2H2 | HPRD, BioGRID | empirical | 9130708 11062469 17643375 |
| CDK7 | GTF2H3 | BioGRID | empirical | 17643375 21157430 |
| CDK7 | GTF2H4 | BioGRID | empirical | 17643375 |
| CDK7 | ANXA2 | BioGRID | empirical | 8692841 |
| CDK7 | HIST1H1A | BioGRID | empirical | 8692842 |
| CDK7 | HDAC2 | BioGRID | empirical | 12527756 |
| CDK7 | HLA-DQA1 | IntAct | empirical | 21988832 |
| CDK7 | HNRNPU | BioGRID | empirical | 10490622 17643375 |
| CDK7 | HSD17B4 | IntAct | empirical | 21988832 |
| CDK7 | HSP90AB1 | BioGRID | empirical | 17643375 |
| CDK7 | AR | HPRD | empirical | 10734072 |
| CDK7 | LASP1 | HPRD | empirical | 12571245 |
| CDK7 | GTF2H5 | HPRD, BioGRID | empirical | 15220921 |
| CDK7 | SMAD1 | BioGRID | empirical | 19914168 |
| CDK7 | ARRB2 | IntAct | empirical | 17620599 |
| CDK7 | MCM7 | HPRD | empirical | 11056214 |
| CDK7 | MNAT1 | HPRD, IntAct, BioGRID, Reactome | empirical | 9130708 8521393 8521818 12527756 17643375 |
| CDK7 | POLR2A | BioGRID | empirical | 8692842 18391197 |
| CDK7 | RARA | HPRD | empirical | 15249124 |
| CDK7 | BRCA1 | HPRD | empirical | 15282296 |
| CDK7 | SUPT5H | BioGRID | empirical | 10958691 |
| CDK7 | TAF7 | BioGRID | empirical | 18391197 |
| CDK7 | TCEA1 | BioGRID | empirical | 9305922 |
| CDK7 | THRA | HPRD, BioGRID | empirical | 15249124 |
| CDK7 | TP53 | BioGRID | empirical | 9372954 9840937 |
| CDK7 | UBC | BioGRID | empirical | 21139048 21906983 |
| CDK7 | VDR | HPRD | empirical | 15249124 |
| CDK7 | PCGF6 | HPRD | empirical | 12167161 |
| CDK7 | CCNH | HPRD, IntAct, BioGRID, Reactome | empirical | 8078587 9056480 8521818 8521393 10958691 17643375 8692841 |
| CDK7 | MTA1 | BioGRID | empirical | 12527756 |
| CDK7 | MED21 | BioGRID | empirical | 9315662 |
| CDK7 | CDK1 | HPRD | empirical | 7944411 11113184 |
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
Publications: 174
-
Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase/PKC-ι-mediated signaling cascade in glioblastoma.
Desai SR, Pillai PP, Patel RS, McCray AN, Win-Piazza HY, Acevedo-Duncan ME
Carcinogenesis. 2012
PubMed ID: 22021906
-
A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor.
Egly JM, Coin F
DNA Repair (Amst). 2011
PubMed ID: 21592869
-
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
-
The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process.
Chymkowitch P, Le May N, Charneau P, Compe E, Egly JM
EMBO J. 2011
PubMed ID: 21157430
-
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
-
Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.
Slattery ML, Herrick JS, Lundgreen A, Fitzpatrick FA, Curtin K, Wolff RK
Carcinogenesis. 2010
PubMed ID: 20622004
-
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium
Am J Epidemiol. 2010
PubMed ID: 20522537
-
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
-
Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.
Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I
J Biol Chem. 2010
PubMed ID: 20360007
-
Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
Patel SA, Simon MC
J Biol Chem. 2010
PubMed ID: 20231280
-
R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.
Rogalińska M, Błoński JZ, Komina O, Góralski P, Zołnierczyk JD, Piekarski H, Robak T, Kiliańska ZM, Wesierska-Gadek J
J Cell Biochem. 2010
PubMed ID: 19911397
-
Combined genetic effect of CDK7 and ESR1 polymorphisms on breast cancer.
Jeon S, Choi JY, Lee KM, Park SK, Yoo KY, Noh DY, Ahn SH, Kang D
Breast Cancer Res Treat. 2009
PubMed ID: 19941161
-
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL
Br J Cancer. 2009
PubMed ID: 19738611
-
TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II.
Glover-Cutter K, Larochelle S, Erickson B, Zhang C, Shokat K, Fisher RP, Bentley DL
Mol Cell Biol. 2009
PubMed ID: 19667075
-
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
-
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.
Bockstaele L, Bisteau X, Paternot S, Roger PP
Mol Cell Biol. 2009
PubMed ID: 19487459
-
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
-
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
-
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
-
TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II.
Akhtar MS, Heidemann M, Tietjen JR, Zhang DW, Chapman RD, Eick D, Ansari AZ
Mol Cell. 2009
PubMed ID: 19450536
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
-
DNA-Bound peptides control the mRNA transcription through CDK7.
Lv X, Wang J, Dong Z, Lv F, Qin Y
Peptides. 2009
PubMed ID: 19071173
-
Cell cycle, CDKs and cancer: a changing paradigm.
Malumbres M, Barbacid M
Nat Rev Cancer. 2009
PubMed ID: 19238148
-
Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation.
Lolli G
Nucleic Acids Res. 2009
PubMed ID: 19136461
-
SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation.
Yang WH, Heaton JH, Brevig H, Mukherjee S, Iñiguez-Lluhí JA, Hammer GD
Mol Cell Biol. 2009
PubMed ID: 19015234
-
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
-
Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
Helenius K, Yang Y, Alasaari J, Mäkelä TP
Mol Cell Biol. 2009
PubMed ID: 18981214
-
Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
J Proteome Res. 2008
PubMed ID: 19367708
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
-
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
-
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
-
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
-
[Expression and clinical significance of cyclin H and CDK7 in human hemangiomas]
Liu J, Zhang DL, Shan SG
Zhonghua Zheng Xing Wai Ke Za Zhi. 2008
PubMed ID: 18950027
-
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
Gegonne A, Weissman JD, Lu H, Zhou M, Dasgupta A, Ribble R, Brady JN, Singer DS
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18391197
-
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
-
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
-
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.
Lewis AE, Rusten M, Hoivik EA, Vikse EL, Hansson ML, Wallberg AE, Bakke M
Mol Endocrinol. 2008
PubMed ID: 17901130
-
AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells.
Oven I, Brdicková N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM
Mol Cell Biol. 2007
PubMed ID: 17938200
-
Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population.
Li Y, Jin G, Wang H, Liu H, Qian J, Gu S, Ma H, Miao R, Hu Z, Sun W, Wang Y, Jin L, Wei Q, Shen H, Huang W, Lu D
Lung Cancer. 2007
PubMed ID: 17707548
-
Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells.
Luo P, Wang A, Payne KJ, Peng H, Wang JG, Parrish YK, Rogerio JW, Triche TJ, He Q, Wu L
Stem Cells. 2007
PubMed ID: 17628022
-
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
-
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
-
Recognition of Cdk2 by Cdk7.
Lolli G, Johnson LN
Proteins. 2007
PubMed ID: 17373709
-
Glucose regulation of CDK7, a putative thiol related gene, in experimental diabetic nephropathy.
Malik AN, Rossios C, Al-Kafaji G, Shah A, Page RA
Biochem Biophys Res Commun. 2007
PubMed ID: 17416350
-
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP
Mol Cell. 2007
PubMed ID: 17386261
-
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
-
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
-
Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.
Yu J, Guo QL, You QD, Zhao L, Gu HY, Yang Y, Zhang HW, Tan Z, Wang X
Carcinogenesis. 2007
PubMed ID: 17012222
-
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD
Cell Metab. 2007
PubMed ID: 17276355
-
Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".
Bockstaele L, Kooken H, Libert F, Paternot S, Dumont JE, de Launoit Y, Roger PP, Coulonval K
Mol Cell Biol. 2006
PubMed ID: 16782892
-
The LIFEdb database in 2006.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S
Nucleic Acids Res. 2006
PubMed ID: 16381901
-
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP
Nat Struct Mol Biol. 2006
PubMed ID: 16327805
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K
Mol Cell. 2005
PubMed ID: 16109376
-
An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth.
Lypowy J, Chen IY, Abdellatif M
J Biol Chem. 2005
PubMed ID: 15886195
-
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
Lolli G, Johnson LN
Cell Cycle. 2005
PubMed ID: 15876871
-
Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells.
Bicaku E, Patel R, Acevedo-Duncan M
Tissue Cell. 2005
PubMed ID: 15695176
-
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
-
Negative modulation of androgen receptor transcriptional activity by Daxx.
Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM
Mol Cell Biol. 2004
PubMed ID: 15572661
-
The crystal structure of human CDK7 and its protein recognition properties.
Lolli G, Lowe ED, Brown NR, Johnson LN
Structure. 2004
PubMed ID: 15530371
-
From ORFeome to biology: a functional genomics pipeline.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A
Genome Res. 2004
PubMed ID: 15489336
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation.
Ito S, Takeyama K, Yamamoto A, Sawatsubashi S, Shirode Y, Kouzmenko A, Tabata T, Kato S
Genes Cells. 2004
PubMed ID: 15461668
-
The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
-
BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels.
Moisan A, Larochelle C, Guillemette B, Gaudreau L
Mol Cell Biol. 2004
PubMed ID: 15282296
-
hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.
Nevado J, Tenbaum SP, Aranda A
Mol Cell Endocrinol. 2004
PubMed ID: 15249124
-
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.
Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W
Nat Genet. 2004
PubMed ID: 15220921
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1.
Pinhero R, Liaw P, Yankulov K
Biol Proced Online. 2004
PubMed ID: 15328539
-
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
-
The Tat/TAR-dependent phosphorylation of RNA polymerase II C-terminal domain stimulates cotranscriptional capping of HIV-1 mRNA.
Zhou M, Deng L, Kashanchi F, Brady JN, Shatkin AJ, Kumar A
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14569024
-
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
-
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.
Yeo M, Lin PS, Dahmus ME, Gill GN
J Biol Chem. 2003
PubMed ID: 12721286
-
The histidine triad protein Hint is not required for murine development or Cdk7 function.
Korsisaari N, Rossi DJ, Luukko K, Huebner K, Henkemeyer M, Mäkelä TP
Mol Cell Biol. 2003
PubMed ID: 12748294
-
Rrn3 becomes inactivated in the process of ribosomal DNA transcription.
Hirschler-Laszkiewicz I, Cavanaugh AH, Mirza A, Lun M, Hu Q, Smink T, Rothblum LI
J Biol Chem. 2003
PubMed ID: 12646563
-
Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.
Butt E, Gambaryan S, Göttfert N, Galler A, Marcus K, Meyer HE
J Biol Chem. 2003
PubMed ID: 12571245
-
MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions.
Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R
J Biol Chem. 2003
PubMed ID: 12527756
-
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.
Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I
EMBO Rep. 2002
PubMed ID: 12393749
-
Transcription factor TFIIH components enhance the GR coactivator activity but not the cell cycle-arresting activity of the human immunodeficiency virus type-1 protein Vpr.
Kino T, Tsukamoto M, Chrousos G
Biochem Biophys Res Commun. 2002
PubMed ID: 12379213
-
Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo.
Lizcano JM, Deak M, Morrice N, Kieloch A, Hastie CJ, Dong L, Schutkowski M, Reimer U, Alessi DR
J Biol Chem. 2002
PubMed ID: 12023960
-
MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation.
Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H
Genes Cells. 2002
PubMed ID: 12167161
-
The cyclin H/cdk7/Mat1 kinase activity is regulated by CK2 phosphorylation of cyclin H.
Schneider E, Kartarius S, Schuster N, Montenarh M
Oncogene. 2002
PubMed ID: 12140753
-
HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription.
Nekhai S, Zhou M, Fernandez A, Lane WS, Lamb NJ, Brady J, Kumar A
Biochem J. 2002
PubMed ID: 12049628
-
Phosphorylation of the CCAAT displacement protein (CDP)/Cux transcription factor by cyclin A-Cdk1 modulates its DNA binding activity in G(2).
Santaguida M, Ding Q, Bérubé G, Truscott M, Whyte P, Nepveu A
J Biol Chem. 2001
PubMed ID: 11584018
-
A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.
Sandrock B, Egly JM
J Biol Chem. 2001
PubMed ID: 11445587
-
Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.
Gnatt AL, Cramer P, Fu J, Bushnell DA, Kornberg RD
Science. 2001
PubMed ID: 11313499
-
Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse.
Kim JM, McGaughy JT, Bogle RK, Ravnik SE
Biol Reprod. 2001
PubMed ID: 11319144
-
Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase.
Kim JB, Sharp PA
J Biol Chem. 2001
PubMed ID: 11145967
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Garrett S, Barton WA, Knights R, Jin P, Morgan DO, Fisher RP
Mol Cell Biol. 2001
PubMed ID: 11113184
-
DNA cloning using in vitro site-specific recombination.
Hartley JL, Temple GF, Brasch MA
Genome Res. 2000
PubMed ID: 11076863
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder.
Vermeulen W, Bergmann E, Auriol J, Rademakers S, Frit P, Appeldoorn E, Hoeijmakers JH, Egly JM
Nat Genet. 2000
PubMed ID: 11062469
-
Identification of single nucleotide polymorphisms in human DNA repair genes.
Ford BN, Ruttan CC, Kyle VL, Brackley ME, Glickman BW
Carcinogenesis. 2000
PubMed ID: 11062157
-
The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor.
Wang Y, Xu F, Hall FL
FEBS Lett. 2000
PubMed ID: 11056214
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.
Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA
Mol Cell Biol. 2000
PubMed ID: 10958691
-
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
-
Distinct regions of MAT1 regulate cdk7 kinase and TFIIH transcription activities.
Busso D, Keriel A, Sandrock B, Poterszman A, Gileadi O, Egly JM
J Biol Chem. 2000
PubMed ID: 10801852
-
Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7.
Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S
Mol Cell. 2000
PubMed ID: 10949034
-
Tat modifies the activity of CDK9 to phosphorylate serine 5 of the RNA polymerase II carboxyl-terminal domain during human immunodeficiency virus type 1 transcription.
Zhou M, Halanski MA, Radonovich MF, Kashanchi F, Peng J, Price DH, Brady JN
Mol Cell Biol. 2000
PubMed ID: 10866664
-
From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator.
Lee DK, Duan HO, Chang C
J Biol Chem. 2000
PubMed ID: 10734072
-
Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures.
Growney JD, Scharf JM, Kunkel LM, Dietrich WF
Genomics. 2000
PubMed ID: 10708519
-
The FBP interacting repressor targets TFIIH to inhibit activated transcription.
Liu J, He L, Collins I, Ge H, Libutti D, Li J, Egly JM, Levens D
Mol Cell. 2000
PubMed ID: 10882074
-
Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator.
Nekhai S, Shukla RR, Fernandez A, Kumar A, Lamb NJ
Virology. 2000
PubMed ID: 10639311
-
Quality control by DNA repair.
Lindahl T, Wood RD
Science. 1999
PubMed ID: 10583946
-
Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation.
Gao CY, Rampalli AM, Cai HC, He HY, Zelenka PS
Exp Eye Res. 1999
PubMed ID: 10620399
-
hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.
Kim MK, Nikodem VM
Mol Cell Biol. 1999
PubMed ID: 10490622
-
Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase.
Vandel L, Kouzarides T
EMBO J. 1999
PubMed ID: 10428966
-
Direct evidence that HIV-1 Tat stimulates RNA polymerase II carboxyl-terminal domain hyperphosphorylation during transcriptional elongation.
Isel C, Karn J
J Mol Biol. 1999
PubMed ID: 10438593
-
Inhibition of transcription by the trimeric cyclin-dependent kinase 7 complex.
Bochar DA, Pan ZQ, Knights R, Fisher RP, Shilatifard A, Shiekhattar R
J Biol Chem. 1999
PubMed ID: 10224071
-
Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase.
Chen D, Zhou Q
Mol Cell Biol. 1999
PubMed ID: 10082552
-
Tat-associated kinase (P-TEFb): a component of transcription preinitiation and elongation complexes.
Ping YH, Rana TM
J Biol Chem. 1999
PubMed ID: 10066804
-
An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor.
Ossipow V, Fonjallaz P, Schibler U
Mol Cell Biol. 1999
PubMed ID: 9891058
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
DNA damage recognition during nucleotide excision repair in mammalian cells.
Wood RD
Biochimie. 1999
PubMed ID: 10214908
-
Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
Tirode F, Busso D, Coin F, Egly JM
Mol Cell. 1999
PubMed ID: 10024882
-
Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
Kershnar E, Wu SY, Chiang CM
J Biol Chem. 1998
PubMed ID: 9852112
-
Regulation of CAK kinase activity by p53.
Schneider E, Montenarh M, Wagner P
Oncogene. 1998
PubMed ID: 9840937
-
The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7.
Akoulitchev S, Reinberg D
Genes Dev. 1998
PubMed ID: 9832506
-
Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.
Tsukamoto T, Shibagaki Y, Niikura Y, Mizumoto K
Biochem Biophys Res Commun. 1998
PubMed ID: 9790902
-
The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor.
Li XY, Green MR
Genes Dev. 1998
PubMed ID: 9765201
-
Transcriptional control: Tat cofactors and transcriptional elongation.
Yankulov K, Bentley D
Curr Biol. 1998
PubMed ID: 9651670
-
Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.
Jansa P, Mason SW, Hoffmann-Rohrer U, Grummt I
EMBO J. 1998
PubMed ID: 9582279
-
Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.
Yamada-Okabe T, Doi R, Shimmi O, Arisawa M, Yamada-Okabe H
Nucleic Acids Res. 1998
PubMed ID: 9512541
-
The role of Cdk7 in CAK function, a retro-retrospective.
Harper JW, Elledge SJ
Genes Dev. 1998
PubMed ID: 9450924
-
Tat, Tat-associated kinase, and transcription.
Jeang KT
J Biomed Sci. 1998
PubMed ID: 9570510
-
Three transitions in the RNA polymerase II transcription complex during initiation.
Holstege FC, Fiedler U, Timmers HT
EMBO J. 1997
PubMed ID: 9405375
-
p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ
Mol Cell Biol. 1997
PubMed ID: 9372954
-
The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.
Cujec TP, Okamoto H, Fujinaga K, Meyer J, Chamberlin H, Morgan DO, Peterlin BM
Genes Dev. 1997
PubMed ID: 9334327
-
CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription.
Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA
Mol Cell Biol. 1997
PubMed ID: 9315662
-
A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity.
Nekhai S, Shukla RR, Kumar A
J Virol. 1997
PubMed ID: 9311822
-
Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators.
Pan G, Aso T, Greenblatt J
J Biol Chem. 1997
PubMed ID: 9305922
-
Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription.
García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB
EMBO J. 1997
PubMed ID: 9184228
-
Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.
Rossignol M, Kolb-Cheynel I, Egly JM
EMBO J. 1997
PubMed ID: 9130708
-
The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme.
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM
Mol Cell Biol. 1997
PubMed ID: 9121429
-
Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes.
García-Martínez LF, Ivanov D, Gaynor RB
J Biol Chem. 1997
PubMed ID: 9054383
-
Expression in Escherichia coli: purification and characterization of cyclin H, a subunit of the human general transcription/DNA repair factor TFIIH.
Poterszman A, Andersen G, Busso D, Rossignol M, Egly JM, Thierry JC
Protein Expr Purif. 1997
PubMed ID: 9056480
-
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
Ahuja HS, Zhu Y, Zakeri Z
Dev Genet. 1997
PubMed ID: 9438340
-
Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain.
Parada CA, Roeder RG
Nature. 1996
PubMed ID: 8934526
-
The general transcription factors of RNA polymerase II.
Orphanides G, Lagrange T, Reinberg D
Genes Dev. 1996
PubMed ID: 8946909
-
Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat.
Zhou Q, Sharp PA
Science. 1996
PubMed ID: 8849451
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
-
Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8692842
-
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.
Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8692841
-
Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.
Stepanova L, Leng X, Parker SB, Harper JW
Genes Dev. 1996
PubMed ID: 8666233
-
Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation.
Bartkova J, Zemanova M, Bartek J
Int J Cancer. 1996
PubMed ID: 8647641
-
Three functional classes of transcriptional activation domain.
Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D
Mol Cell Biol. 1996
PubMed ID: 8628270
-
CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate.
Weiler MC, Smith JL, Masters JN
J Mol Neurosci. 1996
PubMed ID: 8906616
-
Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.
Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y
Cancer Res. 1995
PubMed ID: 8521393
-
Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.
Aprelikova O, Xiong Y, Liu ET
J Biol Chem. 1995
PubMed ID: 7629134
-
Association of Cdk-activating kinase subunits with transcription factor TFIIH.
Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA
Nature. 1995
PubMed ID: 7885450
-
Cdk-activating kinase complex is a component of human transcription factor TFIIH.
Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D
Nature. 1995
PubMed ID: 7533895
-
Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.
Desai D, Wessling HC, Fisher RP, Morgan DO
Mol Cell Biol. 1995
PubMed ID: 7799941
-
Sequence of the cDNA encoding murine CRK4 protein kinase.
Stepanova LYu, Ershler MA, Belyavsky AV
Gene. 1994
PubMed ID: 7959010
-
Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase.
Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, Cavadore JC, Dorée M, Blanchard JM
Oncogene. 1994
PubMed ID: 7936635
-
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
Matsuoka M, Kato JY, Fisher RP, Morgan DO, Sherr CJ
Mol Cell Biol. 1994
PubMed ID: 7935441
-
Human and Xenopus mo15 messenger-RNA are highly conserved but show different patterns of expression in adult tissues.
Kobelt D, Karn T, Hock B, Holtrich U, Brauninger A, Wolf G, Strebhardt K, Rubsamenwaigmann K
Oncol Rep. 1994
PubMed ID: 21607529
-
Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.
Williams RT, Wu L, Carbonaro-Hall DA, Hall FL
Arch Biochem Biophys. 1994
PubMed ID: 7944411
-
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
Tassan JP, Schultz SJ, Bartek J, Nigg EA
J Cell Biol. 1994
PubMed ID: 7929589
-
A cyclin associated with the CDK-activating kinase MO15.
Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA
Nature. 1994
PubMed ID: 8078587
-
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase.
Fisher RP, Morgan DO
Cell. 1994
PubMed ID: 8069918
-
Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase.
Wu L, Yee A, Liu L, Carbonaro-Hall D, Venkatesan N, Tolo VT, Hall FL
Oncogene. 1994
PubMed ID: 8208556
-
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB
Oncogene. 1994
PubMed ID: 8208544
-
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.
Ershler M, Nagorskaya TV, Visser JW, Belyavsky AV
Gene. 1993
PubMed ID: 8444355
-
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.
Gilardi-Hebenstreit P, Nieto MA, Frain M, Mattéi MG, Chestier A, Wilkinson DG, Charnay P
Oncogene. 1992
PubMed ID: 1281307
-
[Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells]
Ershler MA, Nagorskaia TV, Fisser IaV, Beliavskiĭ AV
Dokl Akad Nauk. 1992
PubMed ID: 1459009
-
Abortive initiation is increased only for the weakest members of a set of down mutants of the adenovirus 2 major late promoter.
Jacob GA, Luse SW, Luse DS
J Biol Chem. 1991
PubMed ID: 1939271
-
ATP activates transcription initiation from promoters by RNA polymerase II in a reversible step prior to RNA synthesis.
Conaway RC, Conaway JW
J Biol Chem. 1988
PubMed ID: 2449431
Model Organism Phenotype Links
|
Relevant resources: