CDK2

Summary Top Help

Gene Description:

cyclin dependent kinase 2; cyclin-dependent kinase 2

Synonyms:

A630093N05Rik, p33(CDK2), CDK2, Cdk2

Orthologs:

Human CDK2 (protein-coding), Mouse Cdk2 (protein-coding), Rat Cdk2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Human: 1 Mouse: 1 Rat: 1

Associated Regions: 1 Available

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
12q13.2	Human	chr12:56351346..56805309	0.45	26	rs2292239

Other Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 12q13.2 Orthologous Region	Mouse	chr10:127691143..128152417	0.46	28
Human 12q13.2 Orthologous Region	Rat	chr7:1562496..2014711	0.45	30

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr12:56360553..56366568 (61 kb) View in Genome Browser

(Mouse) NCBIM37 - chr10:128134995..128142107 (7.11 kb) View in Genome Browser

(Rat) RGSC3.4 - chr7:2000196..2007682 (7.49 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CDK2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CDK2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 8

Biocarta: 10

Reactome: 30

NCI-Nature Pathway Interaction Database: 12

Gene Ontology: 53

Publications from PubMed Top Help

Type 1 Diabetes Publications: 5

Publications: 612

Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity.
Huang SY, Hsieh MJ, Chen CY, Chen YJ, Chen JY, Chen MR, Tsai CH, Lin SF, Hsu TY
J Gen Virol. 2012
PubMed ID: 21918011
Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.
Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, Okazaki T, Kitajima S
J Biol Chem. 2011
PubMed ID: 22045811
Phosphorylation of MCM3 protein by cyclin E/cyclin-dependent kinase 2 (Cdk2) regulates its function in cell cycle.
Li J, Deng M, Wei Q, Liu T, Tong X, Ye X
J Biol Chem. 2011
PubMed ID: 21965652
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
Mori T, Ikeda DD, Fukushima T, Takenoshita S, Kochi H
Cell Cycle. 2011
PubMed ID: 21952639
Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma.
Ciznadija D, Liu Y, Pyonteck SM, Holland EC, Koff A
Cancer Res. 2011
PubMed ID: 21844184
NF-κB induces abnormal centrosome amplification by upregulation of CDK2 in laryngeal squamous cell cancer.
Liu JL, Ma HP, Lu XL, Sun SH, Guo X, Li FC
Int J Oncol. 2011
PubMed ID: 21769424
Macrophage-conditioned medium inhibits the activation of cyclin-dependent kinase 2 by adipogenic inducers in 3T3-L1 preadipocytes.
Ide J, Gagnon A, Molgat AS, Landry A, Foster C, Sorisky A
J Cell Physiol. 2011
PubMed ID: 21660953
The structure of a monomeric mutant Cks protein reveals multiple functions for a conserved hinge-region proline.
Balog ER, Saetern OC, Finch W, Hoeft CO, Thai V, Harvey SL, Kellogg DR, Rubin SM
J Mol Biol. 2011
PubMed ID: 21704044
NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
Chae HD, Kim J, Shin DY
BMB Rep. 2011
PubMed ID: 21871181
VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling.
Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelièvre V
J Clin Invest. 2011
PubMed ID: 21737879
MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis.
Tian RQ, Wang XH, Hou LJ, Jia WH, Yang Q, Li YX, Liu M, Li X, Tang H
J Biol Chem. 2011
PubMed ID: 21646351
Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.
Lee J, Kim KH, Jeong S
Bioorg Med Chem Lett. 2011
PubMed ID: 21684737
Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration.
Sekiya S, Suzuki A
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21690373
c-ETS1 facilitates G1/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation.
Singh AK, Swarnalatha M, Kumar V
J Biol Chem. 2011
PubMed ID: 21515670
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP
Mol Cell. 2011
PubMed ID: 21658603
CDK6 kinase activity is required for thymocyte development.
Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW
Blood. 2011
PubMed ID: 21508411
Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip.
Machold R, Klein C, Fishell G
Gene Expr Patterns. 2011
PubMed ID: 21440680
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival.
Afanasyeva EA, Mestdagh P, Kumps C, Vandesompele J, Ehemann V, Theissen J, Fischer M, Zapatka M, Brors B, Savelyeva L, Sagulenko V, Speleman F, Schwab M, Westermann F
Cell Death Differ. 2011
PubMed ID: 21233845
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Huang X, Summers MK, Pham V, Lill JR, Liu J, Lee G, Kirkpatrick DS, Jackson PK, Fang G, Dixit VM
Mol Cell. 2011
PubMed ID: 21596315
Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor.
Liu NA, Jiang H, Ben-Shlomo A, Wawrowsky K, Fan XM, Lin S, Melmed S
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21536883
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
Moshe Y, Bar-On O, Ganoth D, Hershko A
J Biol Chem. 2011
PubMed ID: 21454540
Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification.
Hanashiro K, Brancaccio M, Fukasawa K
Oncogene. 2011
PubMed ID: 21242972
Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
Bao ZQ, Jacobsen DM, Young MA
Structure. 2011
PubMed ID: 21565702
Cdk2-null mice are resistant to ErbB-2-induced mammary tumorigenesis.
Ray D, Terao Y, Christov K, Kaldis P, Kiyokawa H
Neoplasia. 2011
PubMed ID: 21532884
Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E.
Akli S, Van Pelt CS, Bui T, Meijer L, Keyomarsi K
Cancer Res. 2011
PubMed ID: 21385896
Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity.
Hodeify R, Tarcsafalvi A, Megyesi J, Safirstein RL, Price PM
Am J Physiol Renal Physiol. 2011
PubMed ID: 21325496
Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization.
Fiset A, Xu E, Bergeron S, Marette A, Pelletier G, Siminovitch KA, Olivier M, Beauchemin N, Faure RL
Cell Signal. 2011
PubMed ID: 21262353
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous system.
Caillava C, Vandenbosch R, Jablonska B, Deboux C, Spigoni G, Gallo V, Malgrange B, Baron-Van Evercooren A
J Cell Biol. 2011
PubMed ID: 21502361
Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
Pascual-García M, Carbó JM, León T, Matalonga J, Out R, Van Berkel T, Sarrias MR, Lozano F, Celada A, Valledor AF
J Immunol. 2011
PubMed ID: 21398609
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
Neganova I, Vilella F, Atkinson SP, Lloret M, Passos JF, von Zglinicki T, O'Connor JE, Burks D, Jones R, Armstrong L, Lako M
Stem Cells. 2011
PubMed ID: 21319273
Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.
Vacher H, Yang JW, Cerda O, Autillo-Touati A, Dargent B, Trimmer JS
J Cell Biol. 2011
PubMed ID: 21357749
Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.
Suryadinata R, Sadowski M, Steel R, Sarcevic B
J Biol Chem. 2011
PubMed ID: 21148318
Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.
Campbell GR, Baudhuin A, Vranizan K, Ngai J
Mol Cell Neurosci. 2011
PubMed ID: 21194568
Cyclin dependent kinase 1 inhibitors: a review of recent progress.
Wang Q, Su L, Liu N, Zhang L, Xu W, Fang H
Curr Med Chem. 2011
PubMed ID: 21517772
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain.
Ikeda Y, Matsunaga Y, Takiguchi M, Ikeda MA
Gene Expr Patterns. 2011
PubMed ID: 20863901
Cyclin D1 regulates p27(Kip1) stability in B cells.
Bustany S, Tchakarska G, Sola B
Cell Signal. 2011
PubMed ID: 20837141
Ectopic expression of human Cdk2 and its yeast homolog, Ime2, is deleterious to Saccharomyces cerevisiae.
Szwarcwort-Cohen M, Gurevich V, Sagee S, Kassir Y
Cell Cycle. 2010
PubMed ID: 21099355
MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways.
Lin SL, Chang DC, Ying SY, Leu D, Wu DT
Cancer Res. 2010
PubMed ID: 21062975
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
Chen S, Bohrer LR, Rai AN, Pan Y, Gan L, Zhou X, Bagchi A, Simon JA, Huang H
Nat Cell Biol. 2010
PubMed ID: 20935635
Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A.
Fei Q, Guo C, Xu X, Gao J, Zhang J, Chen T, Cui D
Acta Biochim Biophys Sin (Shanghai). 2010
PubMed ID: 20926513
Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance.
Fradet-Turcotte A, Moody C, Laimins LA, Archambault J
J Virol. 2010
PubMed ID: 20844047
In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms.
Lupino E, Buccinnà B, Ramondetti C, Lomartire A, De Marco G, Ricotti E, Tovo PA, Rinaudo MT, Piccinini M
Immunology. 2010
PubMed ID: 20465575
Tipping the balance: Cdk2 enables Myc to suppress senescence.
Hydbring P, Larsson LG
Cancer Res. 2010
PubMed ID: 20713526
Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase.
Maeshima K, Iino H, Hihara S, Funakoshi T, Watanabe A, Nishimura M, Nakatomi R, Yahata K, Imamoto F, Hashikawa T, Yokota H, Imamoto N
Nat Struct Mol Biol. 2010
PubMed ID: 20711190
An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Hirschi A, Cecchini M, Steinhardt RC, Schamber MR, Dick FA, Rubin SM
Nat Struct Mol Biol. 2010
PubMed ID: 20694007
How cyclin A destruction escapes the spindle assembly checkpoint.
Di Fiore B, Pines J
J Cell Biol. 2010
PubMed ID: 20733051
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Puyol M, Martín A, Dubus P, Mulero F, Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M
Cancer Cell. 2010
PubMed ID: 20609353
p53-independent induction of G1 arrest and p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic, through downregulation of c-Myc.
Jeong JH, Kang SS, Park KK, Chang HW, Magae J, Chang YC
Mol Cancer Ther. 2010
PubMed ID: 20587660
Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase.
Hodeify R, Megyesi J, Tarcsafalvi A, Safirstein RL, Price PM
Am J Physiol Renal Physiol. 2010
PubMed ID: 20444741
A cancer-derived mutation in the PSTAIRE helix of cyclin-dependent kinase 2 alters the stability of cyclin binding.
Child ES, Hendrychová T, McCague K, Futreal A, Otyepka M, Mann DJ
Biochim Biophys Acta. 2010
PubMed ID: 20399812
The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development.
Risley MD, Clowes C, Yu M, Mitchell K, Hentges KE
Dev Biol. 2010
PubMed ID: 20347762
Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma.
Jung KH, Kim JK, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Park WS, Lee JY, Nam SW
J Cell Biochem. 2010
PubMed ID: 20512928
Centrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ
Breast Cancer Res Treat. 2010
PubMed ID: 20508983
Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.
Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I
J Biol Chem. 2010
PubMed ID: 20360007
Structural and functional relationship between the Ph1 locus protein 5B2 in wheat and CDK2 in mammals.
Yousafzai FK, Al-Kaff N, Moore G
Funct Integr Genomics. 2010
PubMed ID: 20422243
Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro.
Copeland NA, Sercombe HE, Ainscough JF, Coverley D
J Cell Sci. 2010
PubMed ID: 20215406
p21(Cip1) up-regulated during histone deacetylase inhibitor-induced CD4(+) T-cell anergy selectively associates with mitogen-activated protein kinases.
Selma Dagtas A, Gilbert KM
Immunology. 2010
PubMed ID: 20102411
DNA damage-induced degradation of Cdc25A does not lead to inhibition of Cdk2 activity in mouse embryonic stem cells.
Koledova Z, Kafkova LR, Krämer A, Divoky V
Stem Cells. 2010
PubMed ID: 20104581
SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition.
Kim JA, Lee J, Margolis RL, Fotedar R
Oncogene. 2010
PubMed ID: 20062077
Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.
Kumar S, Barthwal MK, Dikshit M
Free Radic Biol Med. 2010
PubMed ID: 20079829
Coupling of the cell cycle and apoptotic machineries in developing T cells.
Xue L, Sun Y, Chiang L, He B, Kang C, Nolla H, Winoto A
J Biol Chem. 2010
PubMed ID: 20068041
Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition.
Flores O, Wang Z, Knudsen KE, Burnstein KL
Endocrinology. 2010
PubMed ID: 20147522
Insulin-like growth factor binding protein-3 induces G1 cell cycle arrest with inhibition of cyclin-dependent kinase 2 and 4 in MCF-7 human breast cancer cells.
Kim HS, Lee WJ, Lee SW, Chae HW, Kim DH, Oh Y
Horm Metab Res. 2010
PubMed ID: 19960406
Vitamin D-dependent suppression of endothelin-induced vascular smooth muscle cell proliferation through inhibition of CDK2 activity.
Chen S, Law CS, Gardner DG
J Steroid Biochem Mol Biol. 2010
PubMed ID: 19961935
Specific overexpression of cyclin E·CDK2 in early preinvasive and primary breast tumors in female ACI rats induced by estrogen.
Weroha SJ, Lingle WL, Hong Y, Li SA, Li JJ
Horm Cancer. 2010
PubMed ID: 21761349
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.
Adon AM, Zeng X, Harrison MK, Sannem S, Kiyokawa H, Kaldis P, Saavedra HI
Mol Cell Biol. 2010
PubMed ID: 19933848
Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells.
Koledova Z, Kafkova LR, Calabkova L, Krystof V, Dolezel P, Divoky V
Stem Cells Dev. 2010
PubMed ID: 19737069
DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.
Bourke E, Brown JA, Takeda S, Hochegger H, Morrison CG
Oncogene. 2010
PubMed ID: 19838212
Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.
Rodríguez-Ubreva FJ, Cariaga-Martinez AE, Cortés MA, Romero-De Pablos M, Ropero S, López-Ruiz P, Colás B
Oncogene. 2010
PubMed ID: 19838216
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
Hydbring P, Bahram F, Su Y, Tronnersjö S, Högstrand K, von der Lehr N, Sharifi HR, Lilischkis R, Hein N, Wu S, Vervoorts J, Henriksson M, Grandien A, Lüscher B, Larsson LG
Proc Natl Acad Sci U S A. 2010
PubMed ID: 19966300
Selective up-regulation of CDK2 is critical for TLR9 signaling stimulated proliferation of human lung cancer cell.
Xu L, Wang C, Wen Z, Yao X, Liu Z, Li Q, Wu Z, Xu Z, Liang Y, Ren T
Immunol Lett. 2010
PubMed ID: 19854217
Cdk2 is required for p53-independent G2/M checkpoint control.
Chung JH, Bunz F
PLoS Genet. 2010
PubMed ID: 20195506
Expanding the substantial interactome of NEMO using protein microarrays.
Fenner BJ, Scannell M, Prehn JH
PLoS One. 2010
PubMed ID: 20098747
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M
Sci Signal. 2010
PubMed ID: 20068231
A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.
Li C, Andrake M, Dunbrack R, Enders GH
Mol Cell Biol. 2010
PubMed ID: 19858290
Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression.
Sugatani J, Osabe M, Kurosawa M, Kitamura N, Ikari A, Miwa M
Drug Metab Dispos. 2010
PubMed ID: 19797611
p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function.
Liu S, Yamauchi H
Cancer Lett. 2009
PubMed ID: 19631451
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma.
Kim JK, Jung KH, Noh JH, Eun JW, Bae HJ, Xie HJ, Ahn YM, Ryu JC, Park WS, Lee JY, Nam SW
Int J Oncol. 2009
PubMed ID: 19885547
Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
Ma HT, Tsang YH, Marxer M, Poon RY
Mol Cell Biol. 2009
PubMed ID: 19822658
Identification and characterization of CAC1 as a novel CDK2-associated cullin.
Kong Y, Nan K, Yin Y
Cell Cycle. 2009
PubMed ID: 19829063
The transcriptional co-activator PCAF regulates cdk2 activity.
Mateo F, Vidal-Laliena M, Canela N, Zecchin A, Martínez-Balbás M, Agell N, Giacca M, Pujol MJ, Bachs O
Nucleic Acids Res. 2009
PubMed ID: 19773423
SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM
Gastroenterology. 2009
PubMed ID: 19686743
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cunningham JM, Vierkant RA, Sellers TA, Phelan C, Rider DN, Liebow M, Schildkraut J, Berchuck A, Couch FJ, Wang X, Fridley BL, Ovarian Cancer Association Consortium, Gentry-Maharaj A, Menon U, Hogdall E, Kjaer S, Whittemore A, DiCioccio R, Song H, Gayther SA, Ramus SJ, Pharaoh PD, Goode EL
Br J Cancer. 2009
PubMed ID: 19738611
Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.
Beamish H, de Boer L, Giles N, Stevens F, Oakes V, Gabrielli B
J Biol Chem. 2009
PubMed ID: 19703905
Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration.
Jiao J, Qin Z, Li S, Liu H, Lu Z
Oncol Rep. 2009
PubMed ID: 19724860
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
Markowski J, Tyszkiewicz T, Jarzab M, Oczko-Wojciechowska M, Gierek T, Witkowska M, Paluch J, Kowalska M, Wygoda Z, Lange D, Jarzab B
Eur Arch Otorhinolaryngol. 2009
PubMed ID: 19609547
Mechanisms of resistance to interferon-gamma-mediated cell growth arrest in human oral squamous carcinoma cells.
Hiroi M, Mori K, Sekine K, Sakaeda Y, Shimada J, Ohmori Y
J Biol Chem. 2009
PubMed ID: 19596857
Cdk2 plays a critical role in hepatocyte cell cycle progression and survival in the setting of cyclin D1 expression in vivo.
Hanse EA, Nelsen CJ, Goggin MM, Anttila CK, Mullany LK, Berthet C, Kaldis P, Crary GS, Kuriyama R, Albrecht JH
Cell Cycle. 2009
PubMed ID: 19652536
Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value.
Jardin F, Picquenot JM, Parmentier F, Ruminy P, Cornic M, Penther D, Bertrand P, Lanic H, Cassuto O, Humbrecht C, Lemasle E, Wautier A, Bastard C, Tilly H
Br J Haematol. 2009
PubMed ID: 19594747
The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding.
Bakan A, Bahar I
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706521
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.
Satyanarayana A, Kaldis P
Oncogene. 2009
PubMed ID: 19561645
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia?
Wesierska-Gadek J, Krystof V
Ann N Y Acad Sci. 2009
PubMed ID: 19723060
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
Xie R, Medina R, Zhang Y, Hussain S, Colby J, Ghule P, Sundararajan S, Keeler M, Liu LJ, van der Deen M, Mitra P, Lian JB, Rivera-Perez JA, Jones SN, Stein JL, van Wijnen AJ, Stein GS
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19590016
Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.
Kalaszczynska I, Geng Y, Iino T, Mizuno S, Choi Y, Kondratiuk I, Silver DP, Wolgemuth DJ, Akashi K, Sicinski P
Cell. 2009
PubMed ID: 19592082
Degradation of cyclin A is regulated by acetylation.
Mateo F, Vidal-Laliena M, Canela N, Busino L, Martinez-Balbas MA, Pagano M, Agell N, Bachs O
Oncogene. 2009
PubMed ID: 19483727
Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E.
Wang H, Zhang X, Geng L, Teng L, Legerski RJ
J Biol Chem. 2009
PubMed ID: 19423708
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
TNF-alpha regulates vascular smooth muscle cell responses in genetic hypertension.
Lee SJ, Kim WJ, Moon SK
Int Immunopharmacol. 2009
PubMed ID: 19306950
Differential phosphorylation patterns between the Cyclin-A2/CDK2 complex and their monomers.
Casado-Vela J, Martínez-Torrecuadrada JL, Casal JI
Protein Expr Purif. 2009
PubMed ID: 19233286
CDK2 is required for proper homologous pairing, recombination and sex-body formation during male mouse meiosis.
Viera A, Rufas JS, Martínez I, Barbero JL, Ortega S, Suja JA
J Cell Sci. 2009
PubMed ID: 19494131
Origin licensing and p53 status regulate Cdk2 activity during G(1).
Nevis KR, Cordeiro-Stone M, Cook JG
Cell Cycle. 2009
PubMed ID: 19440053
Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.
Sotillo E, Garriga J, Padgaonkar A, Kurimchak A, Cook JG, Graña X
J Biol Chem. 2009
PubMed ID: 19321444
Cdk2 and Cdk4 activities are dispensable for tumorigenesis caused by the loss of p53.
Padmakumar VC, Aleem E, Berthet C, Hilton MB, Kaldis P
Mol Cell Biol. 2009
PubMed ID: 19307310
Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.
Saxena UH, Powell CM, Fecko JK, Cacioppo R, Chou HS, Cooper GM, Hansen U
Mol Cell Biol. 2009
PubMed ID: 19237534
Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
Sweet SM, Bailey CM, Cunningham DL, Heath JK, Cooper HJ
Mol Cell Proteomics. 2009
PubMed ID: 19131326
Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.
Guo D, Ye J, Dai J, Li L, Chen F, Ma D, Ji C
Leuk Res. 2009
PubMed ID: 19091404
Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780.
Nair JS, Ho AL, Tse AN, Coward J, Cheema H, Ambrosini G, Keen N, Schwartz GK
Mol Biol Cell. 2009
PubMed ID: 19225156
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.
Deng M, Li F, Ballif BA, Li S, Chen X, Guo L, Ye X
J Biol Chem. 2009
PubMed ID: 19150984
Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1.
Fuchs S, Herzog D, Sumara G, Büchmann-Møller S, Civenni G, Wu X, Chrostek-Grashoff A, Suter U, Ricci R, Relvas JB, Brakebusch C, Sommer L
Cell Stem Cell. 2009
PubMed ID: 19265663
Cdk2ap1 is required for epigenetic silencing of Oct4 during murine embryonic stem cell differentiation.
Deshpande AM, Dai YS, Kim Y, Kim J, Kimlin L, Gao K, Wong DT
J Biol Chem. 2009
PubMed ID: 19117947
A putative role for cell cycle-related proteins in microtubule-based neuroplasticity.
Schmetsdorf S, Arnold E, Holzer M, Arendt T, Gärtner U
Eur J Neurosci. 2009
PubMed ID: 19302146
Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.
Goode EL, Fridley BL, Vierkant RA, Cunningham JM, Phelan CM, Anderson S, Rider DN, White KL, Pankratz VS, Song H, Hogdall E, Kjaer SK, Whittemore AS, DiCioccio R, Ramus SJ, Gayther SA, Schildkraut JM, Pharaoh PP, Sellers TA
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19258477
Cell cycle, CDKs and cancer: a changing paradigm.
Malumbres M, Barbacid M
Nat Rev Cancer. 2009
PubMed ID: 19238148
Regulation of macrophage activation and septic shock susceptibility via p21(WAF1/CIP1).
Trakala M, Arias CF, García MI, Moreno-Ortiz MC, Tsilingiri K, Fernández PJ, Mellado M, Díaz-Meco MT, Moscat J, Serrano M, Martínez-A C, Balomenos D
Eur J Immunol. 2009
PubMed ID: 19224635
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
Maddika S, Panigrahi S, Wiechec E, Wesselborg S, Fischer U, Schulze-Osthoff K, Los M
Mol Cell Biol. 2009
PubMed ID: 19103742
CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone marrow myeloma cells.
Baughn LB, Di Liberto M, Niesvizky R, Cho HJ, Jayabalan D, Lane J, Liu F, Chen-Kiang S
J Immunol. 2009
PubMed ID: 19201832
Human Cdk2 is a functional homolog of budding yeast Ime2, the meiosis-specific Cdk-like kinase.
Szwarcwort-Cohen M, Kasulin-Boneh Z, Sagee S, Kassir Y
Cell Cycle. 2009
PubMed ID: 19197163
Phosphorylation of cyclin-dependent kinase 2 peptides enhances metal binding.
Baldwin GS
Biochem Biophys Res Commun. 2009
PubMed ID: 19101503
Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition.
Li W, Kotoshiba S, Berthet C, Hilton MB, Kaldis P
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19129496
Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells.
Neganova I, Zhang X, Atkinson S, Lako M
Oncogene. 2009
PubMed ID: 18806832
DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2.
Bento C, Andersson MK, Aman P
BMC Cell Biol. 2009
PubMed ID: 20017906
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
A dual role of Cdk2 in DNA damage response.
Satyanarayana A, Kaldis P
Cell Div. 2009
PubMed ID: 19445729
Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.
Nakayama S, Torikoshi Y, Takahashi T, Yoshida T, Sudo T, Matsushima T, Kawasaki Y, Katayama A, Gohda K, Hortobagyi GN, Noguchi S, Sakai T, Ishihara H, Ueno NT
Breast Cancer Res. 2009
PubMed ID: 19239702
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability.
Narayan N, Massimi P, Banks L
J Cell Sci. 2009
PubMed ID: 19066288
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.
Merrick KA, Larochelle S, Zhang C, Allen JJ, Shokat KM, Fisher RP
Mol Cell. 2008
PubMed ID: 19061641
Spliceosomal protein E regulates neoplastic cell growth by modulating expression of cyclin E/CDK2 and G2/M checkpoint proteins.
Li Z, Pützer BM
J Cell Mol Med. 2008
PubMed ID: 18208561
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.
Lin W, Wu J, Dong H, Bouck D, Zeng FY, Chen T
J Biol Chem. 2008
PubMed ID: 18784074
Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity.
Ullah Z, Kohn MJ, Yagi R, Vassilev LT, DePamphilis ML
Genes Dev. 2008
PubMed ID: 18981479
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury.
Liem DA, Zhao P, Angelis E, Chan SS, Zhang J, Wang G, Berthet C, Kaldis P, Ping P, MacLellan WR
J Mol Cell Cardiol. 2008
PubMed ID: 18692063
Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.
Miyamoto T, Koh E, Sakugawa N, Sato H, Hayashi H, Namiki M, Sengoku K
J Assist Reprod Genet. 2008
PubMed ID: 18941885
Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation.
Fernandes KM, Auld CA, Hopkins RG, Morrison RF
J Cell Biochem. 2008
PubMed ID: 18729080
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2.
Satyanarayana A, Berthet C, Lopez-Molina J, Coppola V, Tessarollo L, Kaldis P
Development. 2008
PubMed ID: 18787066
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis.
Karpurapu M, Wang D, Singh NK, Li Q, Rao GN
J Biol Chem. 2008
PubMed ID: 18667424
Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells.
Simoneau M, Boulanger J, Coulombe G, Renaud MA, Duchesne C, Rivard N
J Biol Chem. 2008
PubMed ID: 18617527
[Effect of CDK2 on proliferation in laryngeal squamous cell carcinoma].
Zhang H, Wang B, Liu R, Wen S, Huangfu H
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 19166026
Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.
Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ
J Med Chem. 2008
PubMed ID: 18656911
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Körner R, Greff Z, Kéri G, Stemmann O, Mann M
Mol Cell. 2008
PubMed ID: 18691976
CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
Macias E, Miliani de Marval PL, De Siervi A, Conti CJ, Senderowicz AM, Rodriguez-Puebla ML
Am J Pathol. 2008
PubMed ID: 18599613
Regulatory phosphorylation of cyclin-dependent kinase 2: insights from molecular dynamics simulations.
Bártová I, Koca J, Otyepka M
J Mol Model. 2008
PubMed ID: 18470542
TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung.
Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W
Eur Respir J. 2008
PubMed ID: 18321928
Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
De Boer L, Oakes V, Beamish H, Giles N, Stevens F, Somodevilla-Torres M, Desouza C, Gabrielli B
Oncogene. 2008
PubMed ID: 18372919
Cyclin A-CDK activity during G1 phase impairs MCM chromatin loading and inhibits DNA synthesis in mammalian cells.
Wheeler LW, Lents NH, Baldassare JJ
Cell Cycle. 2008
PubMed ID: 18635963
Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage.
Chae HD, Kim BM, Yun UJ, Shin DY
Oncogene. 2008
PubMed ID: 18345036
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.
Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM, Poon RY
J Biol Chem. 2008
PubMed ID: 18400748
Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort.
Azzato EM, Driver KE, Lesueur F, Shah M, Greenberg D, Easton DF, Teschendorff AE, Caldas C, Caporaso NE, Pharoah PD
Breast Cancer Res. 2008
PubMed ID: 18507837
Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion.
Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, Draganova K, Lang KS, Paratore C, Leveen P, Suter U, Karlsson S, Born W, Ricci R, Götz M, Sommer L
Cell Stem Cell. 2008
PubMed ID: 18462697
p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells.
Wang Q, Zhou Y, Wang X, Evers BM
Cell Death Differ. 2008
PubMed ID: 18408738
Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128.
Zempolich K, Fuhrman C, Milash B, Flinner R, Greven K, Ryu J, Forbes A, Kerlin K, Nichols RC, Gaffney DK
Gynecol Oncol. 2008
PubMed ID: 18299147
Structure-guided discovery of cyclin-dependent kinase inhibitors.
Fischmann TO, Hruza A, Duca JS, Ramanathan L, Mayhood T, Windsor WT, Le HV, Guzi TJ, Dwyer MP, Paruch K, Doll RJ, Lees E, Parry D, Seghezzi W, Madison V
Biopolymers. 2008
PubMed ID: 17937404
Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.
Sotillo E, Garriga J, Kurimchak A, Graña X
J Biol Chem. 2008
PubMed ID: 18276582
Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis.
Maddika S, Ande SR, Wiechec E, Hansen LL, Wesselborg S, Los M
J Cell Sci. 2008
PubMed ID: 18354084
Evidence of key role of Cdk2 overexpression in pemphigus vulgaris.
Lanza A, Cirillo N, Rossiello R, Rienzo M, Cutillo L, Casamassimi A, de Nigris F, Schiano C, Rossiello L, Femiano F, Gombos F, Napoli C
J Biol Chem. 2008
PubMed ID: 18199752
ATP-dependent activation of p21WAF1/CIP1-associated Cdk2 by Cdc6.
Kan Q, Jinno S, Yamamoto H, Kobayashi K, Okayama H
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18356301
Molecular characterisation of breast cancer patients at high and low recurrence risk.
Bonin S, Brunetti D, Benedetti E, Dotti I, Gorji N, Stanta G
Virchows Arch. 2008
PubMed ID: 18236071
Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4).
Atanasoski S, Boentert M, De Ventura L, Pohl H, Baranek C, Beier K, Young P, Barbacid M, Suter U
Mol Cell Neurosci. 2008
PubMed ID: 18191580
Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival.
Song H, Hogdall E, Ramus SJ, Dicioccio RA, Hogdall C, Quaye L, McGuire V, Whittemore AS, Shah M, Greenberg D, Easton DF, Kjaer SK, Pharoah PD, Gayther SA
Clin Cancer Res. 2008
PubMed ID: 18281541
Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells.
Shin JS, Hong SW, Lee SL, Kim TH, Park IC, An SK, Lee WK, Lim JS, Kim KI, Yang Y, Lee SS, Jin DH, Lee MS
Int J Oncol. 2008
PubMed ID: 18202766
Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population.
Driver KE, Song H, Lesueur F, Ahmed S, Barbosa-Morais NL, Tyrer JP, Ponder BA, Easton DF, Pharoah PD, Dunning AM, Studies in Epidemiology and Risks of Cancer Heredity (SEARCH) Team
Carcinogenesis. 2008
PubMed ID: 18174243
Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C
BMC Nephrol. 2008
PubMed ID: 18721488
Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation.
Bártová I, Koca J, Otyepka M
Protein Sci. 2008
PubMed ID: 18042686
p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.
Satyanarayana A, Hilton MB, Kaldis P
Mol Biol Cell. 2008
PubMed ID: 17942597
Progressive derailment of cell cycle regulators in endometrial carcinogenesis.
Horrée N, van Diest PJ, van der Groep P, Sie-Go DM, Heintz AP
J Clin Pathol. 2008
PubMed ID: 17483252
Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone.
Jablonska B, Aguirre A, Vandenbosch R, Belachew S, Berthet C, Kaldis P, Gallo V
J Cell Biol. 2007
PubMed ID: 18086919
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
CDK2 is dispensable for adult hippocampal neurogenesis.
Vandenbosch R, Borgs L, Beukelaers P, Foidart A, Nguyen L, Moonen G, Berthet C, Kaldis P, Gallo V, Belachew S, Malgrange B
Cell Cycle. 2007
PubMed ID: 18073538
The map kinase ERK regulates renal activity of cyclin-dependent kinase 2 in experimental glomerulonephritis.
Bokemeyer D, Panek D, Kitahara M, Trzaskos JM, Müller CE, Hockemeyer J, Kunter U, Boor P, Floege J, Kramer HJ, Ostendorf T
Nephrol Dial Transplant. 2007
PubMed ID: 17893107
Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.
Macias E, Kim Y, Miliani de Marval PL, Klein-Szanto A, Rodriguez-Puebla ML
Cancer Res. 2007
PubMed ID: 17942901
Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins.
Kim TJ, Lim Y, Kim DW, Kwon JS, Son JH, Jin YR, Son DJ, Jung JC, Avery MA, Hong JT, Yun YP
Vascul Pharmacol. 2007
PubMed ID: 17706465
The activation and inhibition of cyclin-dependent kinase-5 by phosphorylation.
Zhang B, Tan VB, Lim KM, Tay TE
Biochemistry. 2007
PubMed ID: 17713927
Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas.
Faber AC, Chiles TC
Cell Cycle. 2007
PubMed ID: 18156799
Cdk1 is sufficient to drive the mammalian cell cycle.
Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M
Nature. 2007
PubMed ID: 17700700
Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.
Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB, Langlais KK, Backus VL, Schimenti KJ, O'Brien MJ, Eppig JJ, Schimenti JC
PLoS Genet. 2007
PubMed ID: 17784788
CDK2 regulation through PI3K and CDK4 is necessary for cell cycle progression of primary rat hepatocytes.
Wierød L, Rosseland CM, Lindeman B, Oksvold MP, Grøsvik H, Skarpen E, Huitfeldt HS
Cell Prolif. 2007
PubMed ID: 17635516
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage.
Myers JS, Zhao R, Xu X, Ham AJ, Cortez D
Cancer Res. 2007
PubMed ID: 17638878
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Richardson CM, Nunns CL, Williamson DS, Parratt MJ, Dokurno P, Howes R, Borgognoni J, Drysdale MJ, Finch H, Hubbard RE, Jackson PS, Kierstan P, Lentzen G, Moore JD, Murray JB, Simmonite H, Surgenor AE, Torrance CJ
Bioorg Med Chem Lett. 2007
PubMed ID: 17570665
Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation.
Li X, Kim JW, Grønborg M, Urlaub H, Lane MD, Tang QQ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17601773
p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.
Smartt HJ, Guilmeau S, Nasser SV, Nicholas C, Bancroft L, Simpson SA, Yeh N, Yang W, Mariadason JM, Koff A, Augenlicht LH
Gastroenterology. 2007
PubMed ID: 17631145
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.
Berthet C, Rodriguez-Galan MC, Hodge DL, Gooya J, Pascal V, Young HA, Keller J, Bosselut R, Kaldis P
Mol Cell Biol. 2007
PubMed ID: 17485443
Mice thrive without Cdk4 and Cdk2.
Barrière C, Santamaría D, Cerqueira A, Galán J, Martín A, Ortega S, Malumbres M, Dubus P, Barbacid M
Mol Oncol. 2007
PubMed ID: 19383288
Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Brown NR, Lowe ED, Petri E, Skamnaki V, Antrobus R, Johnson LN
Cell Cycle. 2007
PubMed ID: 17495531
Recognition of Cdk2 by Cdk7.
Lolli G, Johnson LN
Proteins. 2007
PubMed ID: 17373709
Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest.
Giono LE, Manfredi JJ
Mol Cell Biol. 2007
PubMed ID: 17371838
Substrate recognition and ubiquitination of SCFSkp2/Cks1 ubiquitin-protein isopeptide ligase.
Xu S, Abbasian M, Patel P, Jensen-Pergakes K, Lombardo CR, Cathers BE, Xie W, Mercurio F, Pagano M, Giegel D, Cox S
J Biol Chem. 2007
PubMed ID: 17409098
Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.
Jeon Y, Lee KY, Ko MJ, Lee YS, Kang S, Hwang DS
J Biol Chem. 2007
PubMed ID: 17293600
Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons.
Alvira D, Tajes M, Verdaguer E, de Arriba SG, Allgaier C, Matute C, Trullas R, Jiménez A, Pallàs M, Camins A
Neuroscience. 2007
PubMed ID: 17343987
Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.
Gayther SA, Song H, Ramus SJ, Kjaer SK, Whittemore AS, Quaye L, Tyrer J, Shadforth D, Hogdall E, Hogdall C, Blaeker J, DiCioccio R, McGuire V, Webb PM, Beesley J, Green AC, Whiteman DC, Australian Ovarian Cancer Study Group, Goodman MT, Lurie G, Carney ME, Modugno F, Ness RB, Edwards RP, Moysich KB, Goode EL, Couch FJ, Cunningham JM, Sellers TA, Wu AH, Pike MC, Iversen ES, Marks JR, Garcia-Closas M, Brinton L, Lissowska J, Peplonska B, Easton DF, Jacobs I, Ponder BA, Schildkraut J, Pearce CL, Chenevix-Trench G, Berchuck A, Pharoah PD, Ovarian Cancer Association Consortium
Cancer Res. 2007
PubMed ID: 17409409
Autocatalytic phosphorylation of CDK2 at the activating Thr160.
Abbas T, Jha S, Sherman NE, Dutta A
Cell Cycle. 2007
PubMed ID: 17361108
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Larochelle S, Merrick KA, Terret ME, Wohlbold L, Barboza NM, Zhang C, Shokat KM, Jallepalli PV, Fisher RP
Mol Cell. 2007
PubMed ID: 17386261
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.
Flores-Delgado G, Liu CW, Sposto R, Berndt N
J Proteome Res. 2007
PubMed ID: 17274640
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H
Mol Cell Proteomics. 2007
PubMed ID: 17192257
How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A.
Welburn JP, Tucker JA, Johnson T, Lindert L, Morgan M, Willis A, Noble ME, Endicott JA
J Biol Chem. 2007
PubMed ID: 17095507
Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD
Cell Metab. 2007
PubMed ID: 17276355
Maid (GCIP) is involved in cell cycle control of hepatocytes.
Sonnenberg-Riethmacher E, Wüstefeld T, Miehe M, Trautwein C, Riethmacher D
Hepatology. 2007
PubMed ID: 17256742
Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity.
Moore NL, Narayanan R, Weigel NL
Steroids. 2007
PubMed ID: 17207508
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Grimmler M, Wang Y, Mund T, Cilensek Z, Keidel EM, Waddell MB, Jäkel H, Kullmann M, Kriwacki RW, Hengst L
Cell. 2007
PubMed ID: 17254966
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation.
Panić L, Tamarut S, Sticker-Jantscheff M, Barkić M, Solter D, Uzelac M, Grabusić K, Volarević S
Mol Cell Biol. 2006
PubMed ID: 17000767
Identification of an hexapeptide that binds to a surface pocket in cyclin A and inhibits the catalytic activity of the complex cyclin-dependent kinase 2-cyclin A.
Canela N, Orzáez M, Fucho R, Mateo F, Gutierrez R, Pineda-Lucena A, Bachs O, Pérez-Payá E
J Biol Chem. 2006
PubMed ID: 17001081
Apoptosis and tumor inhibition induced by human chorionic gonadotropin beta in mouse breast carcinoma.
Shi SQ, Xu L, Zhao G, Yang Y, Peng JP
J Mol Med. 2006
PubMed ID: 16924466
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
Huang H, Regan KM, Lou Z, Chen J, Tindall DJ
Science. 2006
PubMed ID: 17038621
The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism.
Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, Nasheuer HP, Vaziri C
J Biol Chem. 2006
PubMed ID: 16912045
Cyclin-dependent kinase 2 expression in human melanomas and benign melanocytic skin lesions.
Kuźbicki L, Aładowicz E, Chwirot BW
Melanoma Res. 2006
PubMed ID: 17013093
p27Kip1 and cyclin dependent kinase 2 regulate passage through the restriction point.
Hitomi M, Yang K, Guo Y, Fretthold J, Harwalkar J, Stacey DW
Cell Cycle. 2006
PubMed ID: 16969133
Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers.
Deans AJ, Khanna KK, McNees CJ, Mercurio C, Heierhorst J, McArthur GA
Cancer Res. 2006
PubMed ID: 16912201
Membrane depolarization stimulates the proliferation of SH-SY5Y human neuroblastoma cells by increasing retinoblastoma protein (RB) phosphorylation through the activation of cyclin-dependent kinase 2 (Cdk2).
Seo M, Kim Y, Lee YI, Kim SY, Ahn YM, Kang UG, Roh MS, Kim YS, Juhnn YS
Neurosci Lett. 2006
PubMed ID: 16824683
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
Cheng KY, Noble ME, Skamnaki V, Brown NR, Lowe ED, Kontogiannis L, Shen K, Cole PA, Siligardi G, Johnson LN
J Biol Chem. 2006
PubMed ID: 16707497
Glutamate regulates retinal progenitors cells proliferation during development.
Martins RA, Linden R, Dyer MA
Eur J Neurosci. 2006
PubMed ID: 16925590
The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen.
Gérard A, Koundrioukoff S, Ramillon V, Sergère JC, Mailand N, Quivy JP, Almouzni G
EMBO Rep. 2006
PubMed ID: 16826239
Cadmium induces cell cycle arrest in rat kidney epithelial cells in G2/M phase.
Xie J, Shaikh ZA
Toxicology. 2006
PubMed ID: 16730872
Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis.
Bao GC, Wang JG, Jong A
FEBS Lett. 2006
PubMed ID: 16765349
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J
Cell. 2006
PubMed ID: 16777603
Phosphorylation of the linker histone H1 by CDK regulates its binding to HP1alpha.
Hale TK, Contreras A, Morrison AJ, Herrera RE
Mol Cell. 2006
PubMed ID: 16762841
CDK2 is required by MYC to induce apoptosis.
Deb-Basu D, Aleem E, Kaldis P, Felsher DW
Cell Cycle. 2006
PubMed ID: 16760655
Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extra
Inamoto T, Yamochi T, Ohnuma K, Iwata S, Kina S, Inamoto S, Tachibana M, Katsuoka Y, Dang NH, Morimoto C
Clin Cancer Res. 2006
PubMed ID: 16740772
Experimental glaucoma and optic nerve transection induce simultaneous upregulation of proapoptotic and prosurvival genes.
Levkovitch-Verbin H, Dardik R, Vander S, Nisgav Y, Kalev-Landoy M, Melamed S
Invest Ophthalmol Vis Sci. 2006
PubMed ID: 16723461
HPV16 E1--E4 protein is phosphorylated by Cdk2/cyclin A and relocalizes this complex to the cytoplasm.
Davy CE, Ayub M, Jackson DJ, Das P, McIntosh P, Doorbar J
Virology. 2006
PubMed ID: 16540140
Interaction energies for the purine inhibitor roscovitine with cyclin-dependent kinase 2: correlated ab initio quantum-chemical, DFT and empirical calculations.
Dobes P, Otyepka M, Strnad M, Hobza P
Chemistry. 2006
PubMed ID: 16575928
Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication.
Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, Duensing S
Oncogene. 2006
PubMed ID: 16331279
Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation.
Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P
Dev Cell. 2006
PubMed ID: 16678773
Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization.
Bora PS, Kaliappan S, Xu Q, Kumar S, Wang Y, Kaplan HJ, Bora NS
FEBS J. 2006
PubMed ID: 16689928
Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft.
Shukla S, Gupta S
Mol Cancer Ther. 2006
PubMed ID: 16648554
Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes.
Wang GL, Shi X, Salisbury E, Sun Y, Albrecht JH, Smith RG, Timchenko NA
Mol Cell Biol. 2006
PubMed ID: 16537903
Regulation of the transcription factor FOXM1c by Cyclin E/CDK2.
Lüscher-Firzlaff JM, Lilischkis R, Lüscher B
FEBS Lett. 2006
PubMed ID: 16504183
Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics.
Otyepka M, Bártová I, Kríz Z, Koca J
J Biol Chem. 2006
PubMed ID: 16407256
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
Signaling through mutants of the IgA receptor CD89 and consequences for Fc receptor gamma-chain interaction.
Bakema JE, de Haij S, den Hartog-Jager CF, Bakker J, Vidarsson G, van Egmond M, van de Winkel JG, Leusen JH
J Immunol. 2006
PubMed ID: 16517729
Phosphorylation of RIalpha by cyclin-dependent kinase CDK 2/cyclin E modulates the dissociation of the RIalpha-RFC40 complex.
Gupte RS, Traganos F, Darzynkiewicz Z, Lee MY
Cell Cycle. 2006
PubMed ID: 16582606
Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells.
Komamura-Kohno Y, Karasawa-Shimizu K, Saitoh T, Sato M, Hanaoka F, Tanaka S, Ishimi Y
FEBS J. 2006
PubMed ID: 16519687
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Richardson CM, Williamson DS, Parratt MJ, Borgognoni J, Cansfield AD, Dokurno P, Francis GL, Howes R, Moore JD, Murray JB, Robertson A, Surgenor AE, Torrance CJ
Bioorg Med Chem Lett. 2006
PubMed ID: 16325401
Expression patterns of cytokine, growth factor and cell cycle-related genes after partial hepatectomy in rats with thioacetamide-induced cirrhosis.
Yang S, Leow CK, Tan TM
World J Gastroenterol. 2006
PubMed ID: 16534847
p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.
Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR
FEBS Lett. 2006
PubMed ID: 16458891
Inhibition of HIV-1 virus replication using small soluble Tat peptides.
Agbottah E, Zhang N, Dadgar S, Pumfery A, Wade JD, Zeng C, Kashanchi F
Virology. 2006
PubMed ID: 16289656
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
Seo DW, Li H, Qu CK, Oh J, Kim YS, Diaz T, Wei B, Han JW, Stetler-Stevenson WG
J Biol Chem. 2006
PubMed ID: 16326706
Direct interaction of p21 with p50, the small subunit of human DNA polymerase delta.
Li H, Xie B, Rahmeh A, Zhou Y, Lee MY
Cell Cycle. 2006
PubMed ID: 16479163
The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo.
Porse BT, Pedersen TA, Hasemann MS, Schuster MB, Kirstetter P, Luedde T, Damgaard I, Kurz E, Schjerling CK, Nerlov C
Mol Cell Biol. 2006
PubMed ID: 16428455
PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis.
Oh YT, Chun KH, Oh JI, Park JA, Kim YU, Lee SK
Biochem Biophys Res Commun. 2006
PubMed ID: 16343435
Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing.
Tarapore P, Shinmura K, Suzuki H, Tokuyama Y, Kim SH, Mayeda A, Fukasawa K
FEBS Lett. 2006
PubMed ID: 16376875
Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription.
Ammosova T, Berro R, Jerebtsova M, Jackson A, Charles S, Klase Z, Southerland W, Gordeuk VR, Kashanchi F, Nekhai S
Retrovirology. 2006
PubMed ID: 17083724
Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach.
de la Fuente C, Gupta MV, Klase Z, Strouss K, Cahan P, McCaffery T, Galante A, Soteropoulos P, Pumfery A, Fujii M, Kashanchi F
Retrovirology. 2006
PubMed ID: 16822311
Compensation by tumor suppressor genes during retinal development in mice and humans.
Donovan SL, Schweers B, Martins R, Johnson D, Dyer MA
BMC Biol. 2006
PubMed ID: 16672052
The LIFEdb database in 2006.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S
Nucleic Acids Res. 2006
PubMed ID: 16381901
KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2.
Cannon M, Cesarman E, Boshoff C
Blood. 2006
PubMed ID: 16150942
Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
Niture SK, Doneanu CE, Velu CS, Bailey NI, Srivenugopal KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16226712
Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes.
Jansen LA, Uhlmann EJ, Crino PB, Gutmann DH, Wong M
Epilepsia. 2005
PubMed ID: 16393152
Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN
Oncogene. 2005
PubMed ID: 16027724
A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus.
Muzio L, Soria JM, Pannese M, Piccolo S, Mallamaci A
Cereb Cortex. 2005
PubMed ID: 15800025
Depletion of Chk1 leads to premature activation of Cdc2-cyclin B and mitotic catastrophe.
Niida H, Tsuge S, Katsuno Y, Konishi A, Takeda N, Nakanishi M
J Biol Chem. 2005
PubMed ID: 16159883
Cdk2 activity is dispensable for triggering replicon initiation after transient hypoxia in T24 cells.
Stabenow D, Probst H, van Betteraey-Nikoleit M
FEBS J. 2005
PubMed ID: 16262700
Cell cycle sibling rivalry: Cdc2 vs. Cdk2.
Kaldis P, Aleem E
Cell Cycle. 2005
PubMed ID: 16258277
RNA interference directed to CDK2 inhibits HIV-1 transcription.
Ammosova T, Berro R, Kashanchi F, Nekhai S
Virology. 2005
PubMed ID: 16085226
Distinct roles for the mammalian A-type cyclins during oogenesis.
Persson JL, Zhang Q, Wang XY, Ravnik SE, Muhlrad S, Wolgemuth DJ
Reproduction. 2005
PubMed ID: 16183859
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion.
Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB
Mol Cell Biol. 2005
PubMed ID: 16166639
Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos.
Hara KT, Oda S, Naito K, Nagata M, Schultz RM, Aoki F
Dev Biol. 2005
PubMed ID: 16137671
Differential regulation of CDP/Cux p110 by cyclin A/Cdk2 and cyclin A/Cdk1.
Santaguida M, Nepveu A
J Biol Chem. 2005
PubMed ID: 16081423
Cdc2 and Cdk2 play critical roles in low dose doxorubicin-induced cell death through mitotic catastrophe but not in high dose doxorubicin-induced apoptosis.
Park SS, Eom YW, Choi KS
Biochem Biophys Res Commun. 2005
PubMed ID: 16036217
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Human CDK2 inhibition modifies the dynamics of chromatin-bound minichromosome maintenance complex and replication protein A.
Zhu Y, Ishimi Y, Tanudji M, Lees E
Cell Cycle. 2005
PubMed ID: 16082227
Long-term 17alpha-ethinyl estradiol treatment decreases cyclin E and cdk2 expression, reduces cdk2 kinase activity and inhibits S phase entry in regenerating rat liver.
Koroxenidou L, Ohlson LC, Porsch Hällström I
J Hepatol. 2005
PubMed ID: 16019103
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K
Mol Cell. 2005
PubMed ID: 16109376
Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif.
Zhu H, Nie L, Maki CG
J Biol Chem. 2005
PubMed ID: 15964852
A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.
Grishina I, Lattes B
Cell Cycle. 2005
PubMed ID: 16082200
Cdc2-cyclin E complexes regulate the G1/S phase transition.
Aleem E, Kiyokawa H, Kaldis P
Nat Cell Biol. 2005
PubMed ID: 16007079
Aldosterone stimulates proliferation of mesangial cells by activating mitogen-activated protein kinase 1/2, cyclin D1, and cyclin A.
Terada Y, Kobayashi T, Kuwana H, Tanaka H, Inoshita S, Kuwahara M, Sasaki S
J Am Soc Nephrol. 2005
PubMed ID: 15975997
Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.
Machida YJ, Teer JK, Dutta A
J Biol Chem. 2005
PubMed ID: 15944161
p38 mitogen-activated protein kinase contributes to cell cycle regulation by cAMP in FRTL-5 thyroid cells.
Corrèze C, Blondeau JP, Pomérance M
Eur J Endocrinol. 2005
PubMed ID: 15994754
CDK2 translational down-regulation during endothelial senescence.
Freedman DA, Folkman J
Exp Cell Res. 2005
PubMed ID: 15922732
3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues.
Loughney K, Taylor J, Florio VA
Int J Impot Res. 2005
PubMed ID: 15800651
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
Lacy ER, Wang Y, Post J, Nourse A, Webb W, Mapelli M, Musacchio A, Siuzdak G, Kriwacki RW
J Mol Biol. 2005
PubMed ID: 15890360
Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes.
Lu G, Seta KA, Millhorn DE
J Biol Chem. 2005
PubMed ID: 15824106
Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).
Martín A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M, Barbacid M
Cancer Cell. 2005
PubMed ID: 15950907
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system.
Clarke CA, Clarke PR
Biochem J. 2005
PubMed ID: 15707391
D-type cyclins and G1 progression during liver development in the rat.
Boylan JM, Gruppuso PA
Biochem Biophys Res Commun. 2005
PubMed ID: 15809057
Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.
Chinami M, Yano Y, Yang X, Salahuddin S, Moriyama K, Shiroishi M, Turner H, Shirakawa T, Adra CN
J Biol Chem. 2005
PubMed ID: 15671017
Molecular motions of human cyclin-dependent kinase 2.
Barrett CP, Noble ME
J Biol Chem. 2005
PubMed ID: 15695825
Design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation.
Gondeau C, Gerbal-Chaloin S, Bello P, Aldrian-Herrada G, Morris MC, Divita G
J Biol Chem. 2005
PubMed ID: 15649889
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M, West SC
Nature. 2005
PubMed ID: 15800615
Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2.
Liu H, Barr SM, Chu C, Kohtz DS, Kinoshita Y, Johnson EM
Biochem Biophys Res Commun. 2005
PubMed ID: 15707957
Indole-3-carbinol (I3C) inhibits cyclin-dependent kinase-2 function in human breast cancer cells by regulating the size distribution, associated cyclin E forms, and subcellular localization of the CDK2 protein complex.
Garcia HH, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL
J Biol Chem. 2005
PubMed ID: 15611077
cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA.
Naderi S, Wang JY, Chen TT, Gutzkow KB, Blomhoff HK
Mol Biol Cell. 2005
PubMed ID: 15647383
The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles.
Honda R, Lowe ED, Dubinina E, Skamnaki V, Cook A, Brown NR, Johnson LN
EMBO J. 2005
PubMed ID: 15660127
ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.
Varshochi R, Halim F, Sunters A, Alao JP, Madureira PA, Hart SM, Ali S, Vigushin DM, Coombes RC, Lam EW
J Biol Chem. 2005
PubMed ID: 15557281
Expression of cell cycle-related proteins in developing and adult mouse hippocampus.
Schmetsdorf S, Gärtner U, Arendt T
Int J Dev Neurosci. 2005
PubMed ID: 15730892
The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK.
Bártová I, Otyepka M, Kríz Z, Koca J
Protein Sci. 2005
PubMed ID: 15632290
Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity.
Youn CK, Cho HJ, Kim SH, Kim HB, Kim MH, Chang IY, Lee JS, Chung MH, Hahm KS, You HJ
Nat Cell Biol. 2005
PubMed ID: 15619620
Macrophage migration inhibitory factor MIF interferes with the Rb-E2F pathway.
Petrenko O, Moll UM
Mol Cell. 2005
PubMed ID: 15664192
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869759
Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen.
Frouin I, Toueille M, Ferrari E, Shevelev I, Hübscher U
Nucleic Acids Res. 2005
PubMed ID: 16174846
Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2.
Hayami R, Sato K, Wu W, Nishikawa T, Hiroi J, Ohtani-Kaneko R, Fukuda M, Ohta T
Cancer Res. 2005
PubMed ID: 15665273
p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
Baldassarre G, Belletti B, Nicoloso MS, Schiappacassi M, Vecchione A, Spessotto P, Morrione A, Canzonieri V, Colombatti A
Cancer Cell. 2005
PubMed ID: 15652749
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.
Cheng A, Xiong W, Ferrell JE, Solomon MJ
Cell Cycle. 2005
PubMed ID: 15611625
Activation of Cdk2-pRB-E2F1 cell cycle pathway by repeated electroconvulsive shock in the rat frontal cortex.
Kim Y, Seo MS, Kang UG, Yoon SC, Ahn YM, Kim YS, Juhnn YS
Biol Psychiatry. 2005
PubMed ID: 15607308
Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator.
Narayanan R, Adigun AA, Edwards DP, Weigel NL
Mol Cell Biol. 2005
PubMed ID: 15601848
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.
Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, Nishimura EK, Golub TR, Fisher DE
Cancer Cell. 2004
PubMed ID: 15607961
Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.
Pierson-Mullany LK, Lange CA
Mol Cell Biol. 2004
PubMed ID: 15572662
Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation.
Everly DN, Mainou BA, Raab-Traub N
J Virol. 2004
PubMed ID: 15564458
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH
Dev Biol. 2004
PubMed ID: 15531365
Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.
Rosner M, Hengstschläger M
J Biol Chem. 2004
PubMed ID: 15355997
Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes.
Chytil A, Waltner-Law M, West R, Friedman D, Aakre M, Barker D, Law B
J Biol Chem. 2004
PubMed ID: 15355984
A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry.
Matsumoto Y, Maller JL
Science. 2004
PubMed ID: 15514162
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.
Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, Zhu L
Mol Cell. 2004
PubMed ID: 15469821
From ORFeome to biology: a functional genomics pipeline.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A
Genome Res. 2004
PubMed ID: 15489336
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The cyclin A1-CDK2 complex regulates DNA double-strand break repair.
Müller-Tidow C, Ji P, Diederichs S, Potratz J, Bäumer N, Köhler G, Cauvet T, Choudary C, van der Meer T, Chan WY, Nieduszynski C, Colledge WH, Carrington M, Koeffler HP, Restle A, Wiesmüller L, Sobczak-Thépot J, Berdel WE, Serve H
Mol Cell Biol. 2004
PubMed ID: 15456866
Cdk2 activation acts upstream of the mitochondrion during glucocorticoid induced thymocyte apoptosis.
Granés F, Roig MB, Brady HJ, Gil-Gómez G
Eur J Immunol. 2004
PubMed ID: 15368294
The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
Calbó J, Serna C, Garriga J, Graña X, Mazo A
Cell Death Differ. 2004
PubMed ID: 15309028
Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle.
Banchio C, Schang LM, Vance DE
J Biol Chem. 2004
PubMed ID: 15247247
Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures.
Sar F, Lindsey-Boltz LA, Subramanian D, Croteau DL, Hutsell SQ, Griffith JD, Sancar A
J Biol Chem. 2004
PubMed ID: 15226314
Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells.
Henry MK, Nimbalkar D, Hohl RJ, Quelle FW
Exp Cell Res. 2004
PubMed ID: 15302592
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M
Cell. 2004
PubMed ID: 15315761
Mouse development and cell proliferation in the absence of D-cyclins.
Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K, Sicinski P
Cell. 2004
PubMed ID: 15315760
Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium.
Chaudhry HW, Dashoush NH, Tang H, Zhang L, Wang X, Wu EX, Wolgemuth DJ
J Biol Chem. 2004
PubMed ID: 15159393
Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15302935
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.
Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C
J Biol Chem. 2004
PubMed ID: 15159402
Cyclin-dependent kinases regulate the antiproliferative function of Smads.
Matsuura I, Denissova NG, Wang G, He D, Long J, Liu F
Nature. 2004
PubMed ID: 15241418
Self-assembling protein microarrays.
Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J
Science. 2004
PubMed ID: 15232106
Intra-S-phase checkpoint activation by direct CDK2 inhibition.
Zhu Y, Alvarez C, Doll R, Kurata H, Schebye XM, Parry D, Lees E
Mol Cell Biol. 2004
PubMed ID: 15226429
Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.
Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A
Mol Cell Biol. 2004
PubMed ID: 15199159
NIRF induces G1 arrest and associates with Cdk2.
Li Y, Mori T, Hata H, Homma Y, Kochi H
Biochem Biophys Res Commun. 2004
PubMed ID: 15178429
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis.
Bukczynska P, Klingler-Hoffmann M, Mitchelhill KI, Lam MH, Ciccomancini M, Tonks NK, Sarcevic B, Kemp BE, Tiganis T
Biochem J. 2004
PubMed ID: 15030318
Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1.
Ohlson LC, Koroxenidou L, Porsch-Hällström I
J Hepatol. 2004
PubMed ID: 15158336
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC
Anal Chem. 2004
PubMed ID: 15144186
Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.
Toyo-oka K, Hirotsune S, Gambello MJ, Zhou ZQ, Olson L, Rosenfeld MG, Eisenman R, Hurlin P, Wynshaw-Boris A
Hum Mol Genet. 2004
PubMed ID: 15028671
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
Sugimoto N, Tatsumi Y, Tsurumi T, Matsukage A, Kiyono T, Nishitani H, Fujita M
J Biol Chem. 2004
PubMed ID: 14993212
Modulation of beta-catenin phosphorylation/degradation by cyclin-dependent kinase 2.
Park CS, Kim SI, Lee MS, Youn CY, Kim DJ, Jho EH, Song WK
J Biol Chem. 2004
PubMed ID: 14985333
Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.
Kim SI, Park CS, Lee MS, Kwon MS, Jho EH, Song WK
Biochem Biophys Res Commun. 2004
PubMed ID: 15063782
Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.
Liu E, Li X, Yan F, Zhao Q, Wu X
J Biol Chem. 2004
PubMed ID: 15004027
Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein.
Zhou BY, He JJ
Neurosci Lett. 2004
PubMed ID: 15050687
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.
Lacy ER, Filippov I, Lewis WS, Otieno S, Xiao L, Weiss S, Hengst L, Kriwacki RW
Nat Struct Mol Biol. 2004
PubMed ID: 15024385
Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.
Major ML, Lepe R, Costa RH
Mol Cell Biol. 2004
PubMed ID: 15024056
Cdk-mediated phosphorylation of pRB regulates HDAC binding in vitro.
Takaki T, Fukasawa K, Suzuki-Takahashi I, Hirai H
Biochem Biophys Res Commun. 2004
PubMed ID: 15003538
The soluble glucocorticoid-induced tumor necrosis factor receptor causes cell cycle arrest and apoptosis in murine macrophages.
Shin HH, Kim SJ, Lee HS, Choi HS
Biochem Biophys Res Commun. 2004
PubMed ID: 15003506
Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells.
Harwell RM, Mull BB, Porter DC, Keyomarsi K
J Biol Chem. 2004
PubMed ID: 14701826
Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: induction of cyclin A and enhanced CDK2 activity.
Sunters A, Thomas DP, Yeudall WA, Grigoriadis AE
J Biol Chem. 2004
PubMed ID: 14699150
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.
Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI
J Biol Chem. 2004
PubMed ID: 14672936
End-stage differentiation of neutrophil granulocytes in vivo is accompanied by up-regulation of p27kip1 and down-regulation of CDK2, CDK4, and CDK6.
Klausen P, Bjerregaard MD, Borregaard N, Cowland JB
J Leukoc Biol. 2004
PubMed ID: 14694185
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.
Mayer C, Zhao J, Yuan X, Grummt I
Genes Dev. 2004
PubMed ID: 15004009
Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression.
Keenan SM, Lents NH, Baldassare JJ
J Biol Chem. 2004
PubMed ID: 14645251
p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
Liu Y, Wu C, Galaktionov K
J Biol Chem. 2004
PubMed ID: 14597612
Patterns of expression of cyclins A, B1, D, E and cdk 2 in preimplantation mouse embryos.
Waclaw RR, Chatot CL
Zygote. 2004
PubMed ID: 15214576
Early growth response gene 3 regulates thymocyte proliferation during the transition from CD4-CD8- to CD4+CD8+.
Xi H, Kersh GJ
J Immunol. 2004
PubMed ID: 14707069
Protein profile of tax-associated complexes.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F
J Biol Chem. 2004
PubMed ID: 14530271
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Phosphorylations of cyclin-dependent kinase 2 revisited using two-dimensional gel electrophoresis.
Coulonval K, Bockstaele L, Paternot S, Roger PP
J Biol Chem. 2003
PubMed ID: 14551212
Substrate specificity of CDK2-cyclin A. What is optimal?
Stevenson-Lindert LM, Fowler P, Lew J
J Biol Chem. 2003
PubMed ID: 14506259
Transcriptome analysis of mouse stem cells and early embryos.
Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS
PLoS Biol. 2003
PubMed ID: 14691545
The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells.
Ye X, Wei Y, Nalepa G, Harper JW
Mol Cell Biol. 2003
PubMed ID: 14612403
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.
Yang ES, Burnstein KL
J Biol Chem. 2003
PubMed ID: 12954644
Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.
Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W
Science. 2003
PubMed ID: 14615539
The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain.
Joaquin M, Watson RJ
J Biol Chem. 2003
PubMed ID: 12947099
Biochemical characterizations reveal different properties between CDK4/cyclin D1 and CDK2/cyclin A.
Kim DM, Yang K, Yang BS
Exp Mol Med. 2003
PubMed ID: 14646596
SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2.
Moshinsky DJ, Bellamacina CR, Boisvert DC, Huang P, Hui T, Jancarik J, Kim SH, Rice AG
Biochem Biophys Res Commun. 2003
PubMed ID: 14550307
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
Chow JP, Siu WY, Ho HT, Ma KH, Ho CC, Poon RY
J Biol Chem. 2003
PubMed ID: 12912980
Epstein-Barr virus can inhibit genotoxin-induced G1 arrest downstream of p53 by preventing the inactivation of CDK2.
O'Nions J, Allday MJ
Oncogene. 2003
PubMed ID: 14562046
Cdk2 knockout mice are viable.
Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P
Curr Biol. 2003
PubMed ID: 14561402
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Woo M, Hakem R, Furlonger C, Hakem A, Duncan GS, Sasaki T, Bouchard D, Lu L, Wu GE, Paige CJ, Mak TW
Nat Immunol. 2003
PubMed ID: 12970760
RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity.
Guo H, Ray RM, Johnson LR
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12816757
Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.
Yun J, Chae HD, Choi TS, Kim EH, Bang YJ, Chung J, Choi KS, Mantovani R, Shin DY
J Biol Chem. 2003
PubMed ID: 12857729
Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.
Hurlin PJ, Zhou ZQ, Toyo-oka K, Ota S, Walker WL, Hirotsune S, Wynshaw-Boris A
EMBO J. 2003
PubMed ID: 12970171
Spy1 interacts with p27Kip1 to allow G1/S progression.
Porter LA, Kong-Beltran M, Donoghue DJ
Mol Biol Cell. 2003
PubMed ID: 12972555
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.
Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M
Nat Genet. 2003
PubMed ID: 12923533
Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.
Izumiya Y, Lin SF, Ellison TJ, Levy AM, Mayeur GL, Izumiya C, Kung HJ
J Virol. 2003
PubMed ID: 12915577
Regulation of Cdc25A half-life in interphase by cyclin-dependent kinase 2 activity.
Ducruet AP, Lazo JS
J Biol Chem. 2003
PubMed ID: 12801928
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Welcker M, Singer J, Loeb KR, Grim J, Bloecher A, Gurien-West M, Clurman BE, Roberts JM
Mol Cell. 2003
PubMed ID: 14536078
Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73.
Gaiddon C, Lokshin M, Gross I, Levasseur D, Taya Y, Loeffler JP, Prives C
J Biol Chem. 2003
PubMed ID: 12676926
The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter.
Xie RL, Gupta S, Miele A, Shiffman D, Stein JL, Stein GS, van Wijnen AJ
J Biol Chem. 2003
PubMed ID: 12732645
Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.
Henneke G, Koundrioukoff S, Hübscher U
Oncogene. 2003
PubMed ID: 12853968
P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest.
McKenzie PP, Danks MK, Kriwacki RW, Harris LC
Cancer Res. 2003
PubMed ID: 12839982
Human Spy1 promotes survival of mammalian cells following DNA damage.
Barnes EA, Porter LA, Lenormand JL, Dellinger RW, Donoghue DJ
Cancer Res. 2003
PubMed ID: 12839962
Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells.
Gong J, Ammanamanchi S, Ko TC, Brattain MG
Cancer Res. 2003
PubMed ID: 12810668
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.
Zou L, Elledge SJ
Science. 2003
PubMed ID: 12791985
Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant.
Yeh CT, Lu SC, Chao CH, Chao ML
Biochem Biophys Res Commun. 2003
PubMed ID: 12745075
Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.
Iakova P, Awad SS, Timchenko NA
Cell. 2003
PubMed ID: 12757710
PKCeta associates with cyclin E/Cdk2 complex in serum-starved MCF-7 and NIH-3T3 cells.
Shtutman M, Hershko T, Maissel A, Fima E, Livneh E
Exp Cell Res. 2003
PubMed ID: 12729791
CDK2 is involved in the S-phase lengthening induced by glucocorticoids in normal human lymphocytes.
Peiretti A, Baghdassarian N, Gerland LM, Ffrench P, Bryon PA, Magaud JP, Ffrench M
Eur J Cell Biol. 2003
PubMed ID: 12800980
Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation.
Zhou Y, Ching YP, Chun AC, Jin DY
J Biol Chem. 2003
PubMed ID: 12560341
Proliferation of cancer cells despite CDK2 inhibition.
Tetsu O, McCormick F
Cancer Cell. 2003
PubMed ID: 12676582
Regulation of the mammalian cell cycle: a model of the G1-to-S transition.
Qu Z, Weiss JN, MacLellan WR
Am J Physiol Cell Physiol. 2003
PubMed ID: 12388094
Downregulation of p21(waf/cip-1) mediates apoptosis of human hepatocellular carcinoma cells in response to interferon-gamma.
Detjen KM, Murphy D, Welzel M, Farwig K, Wiedenmann B, Rosewicz S
Exp Cell Res. 2003
PubMed ID: 12531694
[Changes in the activity of cyclin-kinase complexes governing cell transition from G1 phase to DNA replication phase in E1A + c-Ha-ras transformants transfected with the bcl-2 gene]
Neliudova AM, Aksenov ND, Pospelova TV
Tsitologiia. 2003
PubMed ID: 12722479
CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.
Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM
Mol Biol Cell. 2003
PubMed ID: 12529437
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.
Law BK, Chytil A, Dumont N, Hamilton EG, Waltner-Law ME, Aakre ME, Covington C, Moses HL
Mol Cell Biol. 2002
PubMed ID: 12417722
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities.
Stead E, White J, Faast R, Conn S, Goldstone S, Rathjen J, Dhingra U, Rathjen P, Walker D, Dalton S
Oncogene. 2002
PubMed ID: 12447695
Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.
Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang XY, Refik-Rogers J, Pines J, Wolgemuth DJ, Koff A
J Biol Chem. 2002
PubMed ID: 12185076
Three different binding sites of Cks1 are required for p27-ubiquitin ligation.
Sitry D, Seeliger MA, Ko TK, Ganoth D, Breward SE, Itzhaki LS, Pagano M, Hershko A
J Biol Chem. 2002
PubMed ID: 12140288
The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein.
Geisen C, Moroy T
J Biol Chem. 2002
PubMed ID: 12149264
p27, cyclin E, and CDK2 expression in normal and cancerous endometrium.
Oshita T, Shigemasa K, Nagai N, Ohama K
Int J Oncol. 2002
PubMed ID: 12239611
HIV-1 Tat interaction with RNA polymerase II C-terminal domain (CTD) and a dynamic association with CDK2 induce CTD phosphorylation and transcription from HIV-1 promoter.
Deng L, Ammosova T, Pumfery A, Kashanchi F, Nekhai S
J Biol Chem. 2002
PubMed ID: 12114499
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.
Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD
Dev Cell. 2002
PubMed ID: 12361598
GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress.
Vairapandi M, Balliet AG, Hoffman B, Liebermann DA
J Cell Physiol. 2002
PubMed ID: 12124778
Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4.
Schang LM, Bantly A, Schaffer PA
J Virol. 2002
PubMed ID: 12097586
Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest.
Dhillon NK, Mudryj M
Oncogene. 2002
PubMed ID: 12096339
Activation mechanism of CDK2: role of cyclin binding versus phosphorylation.
Stevenson LM, Deal MS, Hagopian JC, Lew J
Biochemistry. 2002
PubMed ID: 12081504
HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription.
Nekhai S, Zhou M, Fernandez A, Lane WS, Lamb NJ, Brady J, Kumar A
Biochem J. 2002
PubMed ID: 12049628
Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes.
Korz C, Pscherer A, Benner A, Mertens D, Schaffner C, Leupolt E, Döhner H, Stilgenbauer S, Lichter P
Blood. 2002
PubMed ID: 12036888
The p21(Cip1) protein, a cyclin inhibitor, regulates the levels and the intracellular localization of CDC25A in mice regenerating livers.
Jaime M, Pujol MJ, Serratosa J, Pantoja C, Canela N, Casanovas O, Serrano M, Agell N, Bachs O
Hepatology. 2002
PubMed ID: 11981756
MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity.
McArthur GA, Foley KP, Fero ML, Walkley CR, Deans AJ, Roberts JM, Eisenman RN
Mol Cell Biol. 2002
PubMed ID: 11940659
Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.
Porter LA, Dellinger RW, Tynan JA, Barnes EA, Kong M, Lenormand JL, Donoghue DJ
J Cell Biol. 2002
PubMed ID: 11980914
Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.
Sarcevic B, Mawson A, Baker RT, Sutherland RL
EMBO J. 2002
PubMed ID: 11953320
Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development.
Kalinichenko VV, Zhou Y, Bhattacharyya D, Kim W, Shin B, Bambal K, Costa RH
J Biol Chem. 2002
PubMed ID: 11809759
Cdk5 phosphorylates p53 and regulates its activity.
Zhang J, Krishnamurthy PK, Johnson GV
J Neurochem. 2002
PubMed ID: 12064478
Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4.
Leng X, Noble M, Adams PD, Qin J, Harper JW
Mol Cell Biol. 2002
PubMed ID: 11884610
DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2.
Lan Z, Sever-Chroneos Z, Strobeck MW, Park CH, Baskaran R, Edelmann W, Leone G, Knudsen ES
J Biol Chem. 2002
PubMed ID: 11726663
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
Méndez J, Zou-Yang XH, Kim SY, Hidaka M, Tansey WP, Stillman B
Mol Cell. 2002
PubMed ID: 11931757
Cyclin A- and cyclin E-Cdk complexes shuttle between the nucleus and the cytoplasm.
Jackman M, Kubota Y, den Elzen N, Hagting A, Pines J
Mol Biol Cell. 2002
PubMed ID: 11907280
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Wang F, Corbett D, Osuga H, Osuga S, Ikeda JE, Slack RS, Hogan MJ, Hakim AM, Park DS
J Cereb Blood Flow Metab. 2002
PubMed ID: 11823715
A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication.
Tarapore P, Okuda M, Fukasawa K
Cell Cycle. 2002
PubMed ID: 12429912
Human HTm4 is a hematopoietic cell cycle regulator.
Donato JL, Ko J, Kutok JL, Cheng T, Shirakawa T, Mao XQ, Beach D, Scadden DT, Sayegh MH, Adra CN
J Clin Invest. 2002
PubMed ID: 11781350
Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells.
Schwarze SR, Shi Y, Fu VX, Watson PA, Jarrard DF
Oncogene. 2001
PubMed ID: 11781834
ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3).
Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M
Eur J Biochem. 2001
PubMed ID: 11733001
Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription.
Voit R, Grummt I
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11698641
Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription.
Fojas de Borja P, Collins NK, Du P, Azizkhan-Clifford J, Mudryj M
EMBO J. 2001
PubMed ID: 11598016
C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4.
Wang H, Iakova P, Wilde M, Welm A, Goode T, Roesler WJ, Timchenko NA
Mol Cell. 2001
PubMed ID: 11684017
Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.
Wu CL, Kirley SD, Xiao H, Chuang Y, Chung DC, Zukerberg LR
Cancer Res. 2001
PubMed ID: 11585773
Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors.
Sui L, Dong Y, Ohno M, Sugimoto K, Tai Y, Hando T, Tokuda M
Gynecol Oncol. 2001
PubMed ID: 11585414
SET-related cell division autoantigen-1 (CDA1) arrests cell growth.
Chai Z, Sarcevic B, Mawson A, Toh BH
J Biol Chem. 2001
PubMed ID: 11395479
The role of Thr160 phosphorylation of Cdk2 in substrate recognition.
Holmes JK, Solomon MJ
Eur J Biochem. 2001
PubMed ID: 11532001
The long form of CDK2 arises via alternative splicing and forms an active protein kinase with cyclins A and E.
Ellenrieder C, Bartosch B, Lee GY, Murphy M, Sweeney C, Hergersberg M, Carrington M, Jaussi R, Hunt T
DNA Cell Biol. 2001
PubMed ID: 11506705
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.
Tokuyama Y, Horn HF, Kawamura K, Tarapore P, Fukasawa K
J Biol Chem. 2001
PubMed ID: 11278991
A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.
Sørensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J
Mol Cell Biol. 2001
PubMed ID: 11340163
Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein.
Mattock H, Lane DP, Warbrick E
Exp Cell Res. 2001
PubMed ID: 11302688
Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.
Müller-Tidow C, Wang W, Idos GE, Diederichs S, Yang R, Readhead C, Berdel WE, Serve H, Saville M, Watson R, Koeffler HP
Blood. 2001
PubMed ID: 11264176
Two immunologically distinct human DNA polymerase alpha-primase subpopulations are involved in cellular DNA replication.
Dehde S, Rohaly G, Schub O, Nasheuer HP, Bohn W, Chemnitz J, Deppert W, Dornreiter I
Mol Cell Biol. 2001
PubMed ID: 11259605
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Song H, Hanlon N, Brown NR, Noble ME, Johnson LN, Barford D
Mol Cell. 2001
PubMed ID: 11463386
HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression.
Hall C, Nelson DM, Ye X, Baker K, DeCaprio JA, Seeholzer S, Lipinski M, Adams PD
Mol Cell Biol. 2001
PubMed ID: 11238922
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.
Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M, Hershko A
Nat Cell Biol. 2001
PubMed ID: 11231585
A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene.
Ye X, Zhu C, Harper JW
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11172011
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice.
Geng Y, Yu Q, Sicinska E, Das M, Bronson RT, Sicinski P
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11134518
Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha.
Freire J, Covelo G, Sarandeses C, Díaz-Jullien C, Freire M
Biochem Cell Biol. 2001
PubMed ID: 11310559
Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.
Garrett S, Barton WA, Knights R, Jin P, Morgan DO, Fisher RP
Mol Cell Biol. 2001
PubMed ID: 11113184
PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes.
Kashiwagi M, Ohba M, Watanabe H, Ishino K, Kasahara K, Sanai Y, Taya Y, Kuroki T
Oncogene. 2000
PubMed ID: 11175348
Self-association of coilin reveals a common theme in nuclear body localization.
Hebert MD, Matera AG
Mol Biol Cell. 2000
PubMed ID: 11102515
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
O'Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC, Altieri DC
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11069302
Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis.
Keller C, Krude T
J Biol Chem. 2000
PubMed ID: 10938080
Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms.
Cheng A, Kaldis P, Solomon MJ
J Biol Chem. 2000
PubMed ID: 10934208
DNA cloning using in vitro site-specific recombination.
Hartley JL, Temple GF, Brasch MA
Genome Res. 2000
PubMed ID: 11076863
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation.
Ferguson KL, Callaghan SM, O'Hare MJ, Park DS, Slack RS
J Biol Chem. 2000
PubMed ID: 10915795
NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.
Sansal I, Dupont E, Toru D, Evrard C, Rouget P
Oncogene. 2000
PubMed ID: 11042687
TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase.
Ono T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H
J Biol Chem. 2000
PubMed ID: 10878006
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.
Okuda M, Horn HF, Tarapore P, Tokuyama Y, Smulian AG, Chan PK, Knudsen ES, Hofmann IA, Snyder JD, Bove KE, Fukasawa K
Cell. 2000
PubMed ID: 11051553
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
Ma T, Van Tine BA, Wei Y, Garrett MD, Nelson D, Adams PD, Wang J, Qin J, Chow LT, Harper JW
Genes Dev. 2000
PubMed ID: 10995387
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E
Genes Dev. 2000
PubMed ID: 10995386
Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks.
Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K
J Biol Chem. 2000
PubMed ID: 10846177
p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein.
Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT
Mol Cell Biol. 2000
PubMed ID: 10938106
NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry.
Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M
J Biol Chem. 2000
PubMed ID: 10827081
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.
Arooz T, Yam CH, Siu WY, Lau A, Li KK, Poon RY
Biochemistry. 2000
PubMed ID: 10924145
Differential association of p21Cip1 and p27Kip1 with cyclin E-CDK2 during rat liver regeneration.
Pujol MJ, Jaime M, Serratosa J, Jaumot M, Agell N, Bachs O
J Hepatol. 2000
PubMed ID: 10952244
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells.
Cariou S, Donovan JC, Flanagan WM, Milic A, Bhattacharya N, Slingerland JM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10908655
A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation.
Koundrioukoff S, Jónsson ZO, Hasan S, de Jong RN, van der Vliet PC, Hottiger MO, Hübscher U
J Biol Chem. 2000
PubMed ID: 10930425
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression.
Laronga C, Yang HY, Neal C, Lee MH
J Biol Chem. 2000
PubMed ID: 10767298
The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A.
Luciani MG, Hutchins JR, Zheleva D, Hupp TR
J Mol Biol. 2000
PubMed ID: 10884347
p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase.
Matsuo K, Shintani S, Tsuji T, Nagata E, Lerman M, McBride J, Nakahara Y, Ohyama H, Todd R, Wong DT
FASEB J. 2000
PubMed ID: 10877824
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
Sun Z, Unutmaz D, Zou YR, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR
Science. 2000
PubMed ID: 10875923
An exochelin of Mycobacterium tuberculosis reversibly arrests growth of human vascular smooth muscle cells in vitro.
Pahl PM, Yan XD, Hodges YK, Rosenthal EA, Horwitz MA, Horwitz LD
J Biol Chem. 2000
PubMed ID: 10748174
Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.
Sayed M, Kim SO, Salh BS, Issinger OG, Pelech SL
J Biol Chem. 2000
PubMed ID: 10747897
Inhibition of Mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2.
Ishimi Y, Komamura-Kohno Y, You Z, Omori A, Kitagawa M
J Biol Chem. 2000
PubMed ID: 10748114
Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2.
Yam CH, Siu WY, Lau A, Poon RY
J Biol Chem. 2000
PubMed ID: 10652300
Cell cycle-dependent stimulation of the HIV-1 promoter by Tat-associated CAK activator.
Nekhai S, Shukla RR, Fernandez A, Kumar A, Lamb NJ
Virology. 2000
PubMed ID: 10639311
Phosphorylation of B-Myb regulates its transactivation potential and DNA binding.
Johnson TK, Schweppe RE, Septer J, Lewis RE
J Biol Chem. 1999
PubMed ID: 10593981
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases.
Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T
Oncogene. 1999
PubMed ID: 10602502
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription.
Fu TJ, Peng J, Lee G, Price DH, Flores O
J Biol Chem. 1999
PubMed ID: 10574912
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases.
Brown NR, Noble ME, Endicott JA, Johnson LN
Nat Cell Biol. 1999
PubMed ID: 10559988
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.
Lukas C, Sørensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters JM, Bartek J, Lukas J
Nature. 1999
PubMed ID: 10548110
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.
Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC
Cell. 1999
PubMed ID: 10499802
Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation.
Casaccia-Bonnefil P, Hardy RJ, Teng KK, Levine JM, Koff A, Chao MV
Development. 1999
PubMed ID: 10457012
Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases.
Blomberg I, Hoffmann I
Mol Cell Biol. 1999
PubMed ID: 10454565
Lyn is activated during late G1 of stem-cell-factor-induced cell cycle progression in haemopoietic cells.
Mou S, Linnekin D
Biochem J. 1999
PubMed ID: 10432313
BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site.
Ruffner H, Jiang W, Craig AG, Hunter T, Verma IM
Mol Cell Biol. 1999
PubMed ID: 10373534
Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization.
Lam MH, House CM, Tiganis T, Mitchelhill KI, Sarcevic B, Cures A, Ramsay R, Kemp BE, Martin TJ, Gillespie MT
J Biol Chem. 1999
PubMed ID: 10373465
Skp2 induction and phosphorylation is associated with the late G1 phase of proliferating rat hepatocytes.
Bilodeau M, Talarmin H, Ilyin G, Rescan C, Glaise D, Cariou S, Loyer P, Guguen-Guillouzo C, Baffet G
FEBS Lett. 1999
PubMed ID: 10386600
Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator.
Felzien LK, Farrell S, Betts JC, Mosavin R, Nabel GJ
Mol Cell Biol. 1999
PubMed ID: 10330164
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.
Jiang W, Wells NJ, Hunter T
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10339564
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation.
Marti A, Wirbelauer C, Scheffner M, Krek W
Nat Cell Biol. 1999
PubMed ID: 10559858
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation.
Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M
Genes Dev. 1999
PubMed ID: 10323868
Cumulative effect of phosphorylation of pRB on regulation of E2F activity.
Brown VD, Phillips RA, Gallie BL
Mol Cell Biol. 1999
PubMed ID: 10207050
The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro.
Cuddihy AR, Wong AH, Tam NW, Li S, Koromilas AE
Oncogene. 1999
PubMed ID: 10348343
Phosphorylation by G1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF.
Voit R, Hoffmann M, Grummt I
EMBO J. 1999
PubMed ID: 10202152
C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.
Timchenko NA, Wilde M, Darlington GJ
Mol Cell Biol. 1999
PubMed ID: 10082561
The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis.
Hakem A, Sasaki T, Kozieradzki I, Penninger JM
J Exp Med. 1999
PubMed ID: 10075979
Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.
Bartsch O, Horstmann S, Toprak K, Klempnauer KH, Ferrari S
Eur J Biochem. 1999
PubMed ID: 10095772
Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts.
Hinchcliffe EH, Li C, Thompson EA, Maller JL, Sluder G
Science. 1999
PubMed ID: 9933170
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E
Mol Cell Biol. 1999
PubMed ID: 9891079
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step.
Zhang P, Wong C, Liu D, Finegold M, Harper JW, Elledge SJ
Genes Dev. 1999
PubMed ID: 9925645
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
Petersen BO, Lukas J, Sørensen CS, Bartek J, Helin K
EMBO J. 1999
PubMed ID: 9889196
Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2.
Yam CH, Ng RW, Siu WY, Lau AW, Poon RY
Mol Cell Biol. 1999
PubMed ID: 9858587
Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers.
Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S
Mol Cell Biol. 1999
PubMed ID: 9858585
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice.
Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P
Biochem J. 1998
PubMed ID: 9841865
PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.
Jiang W, Jimenez G, Wells NJ, Hope TJ, Wahl GM, Hunter T, Fukunaga R
Mol Cell. 1998
PubMed ID: 9885575
Cyclin A1 is required for meiosis in the male mouse.
Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ
Nat Genet. 1998
PubMed ID: 9843212
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.
Zariwala M, Liu J, Xiong Y
Oncogene. 1998
PubMed ID: 9840943
The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties.
Saville MK, Watson RJ
Oncogene. 1998
PubMed ID: 9840932
Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3.
ElShamy WM, Fridvall LK, Ernfors P
Neuron. 1998
PubMed ID: 9856457
Phosphorylation of nuclear MyoD is required for its rapid degradation.
Song A, Wang Q, Goebl MG, Harrington MA
Mol Cell Biol. 1998
PubMed ID: 9710583
Association of Cdk2/cyclin E and NF-kappa B complexes at G1/S phase.
Chen E, Li CC
Biochem Biophys Res Commun. 1998
PubMed ID: 9731206
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Gray NS, Wodicka L, Thunnissen AM, Norman TC, Kwon S, Espinoza FH, Morgan DO, Barnes G, LeClerc S, Meijer L, Kim SH, Lockhart DJ, Schultz PG
Science. 1998
PubMed ID: 9677190
Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.
Yagi H, Deguchi K, Aono A, Tani Y, Kishimoto T, Komori T
Blood. 1998
PubMed ID: 9639506
Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity.
Edwards MC, Wong C, Elledge SJ
Mol Cell Biol. 1998
PubMed ID: 9632813
Immunohistochemical study of cyclins D and E and cyclin dependent kinase (cdk) 2 and 4 in human endometrial carcinoma.
Ito K, Sasano H, Yoshida Y, Sato S, Yajima A
Anticancer Res. 1998
PubMed ID: 9673386
Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.
Orend G, Hunter T, Ruoslahti E
Oncogene. 1998
PubMed ID: 9632134
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.
Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A
Mol Cell Biol. 1998
PubMed ID: 9566895
Characterization of the p125 subunit of human DNA polymerase delta and its deletion mutants. Interaction with cyclin-dependent kinase-cyclins.
Wu SM, Zhang P, Zeng XR, Zhang SJ, Mo J, Li BQ, Lee MY
J Biol Chem. 1998
PubMed ID: 9545286
HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin.
Kundu M, Sharma S, De Luca A, Giordano A, Rappaport J, Khalili K, Amini S
J Biol Chem. 1998
PubMed ID: 9525916
Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells.
Poon RY, Hunter T
Oncogene. 1998
PubMed ID: 9546435
Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry.
Zhao J, Dynlacht B, Imai T, Hori T, Harlow E
Genes Dev. 1998
PubMed ID: 9472014
Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells.
Sekiguchi T, Hunter T
Oncogene. 1998
PubMed ID: 9467962
Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK).
Mandal M, Bandyopadhyay D, Goepfert TM, Kumar R
Oncogene. 1998
PubMed ID: 9464540
The differential catalytic activity of alternatively spliced cdk2 alpha and cdk2 beta in the G1/S transition and early S phase.
Kwon TK, Buchholz MA, Jun DY, Kim YH, Nordin AA
Exp Cell Res. 1998
PubMed ID: 9457065
Analysis of cyclin E and CDK2 in ovarian cancer: gene amplification and RNA overexpression.
Marone M, Scambia G, Giannitelli C, Ferrandina G, Masciullo V, Bellacosa A, Benedetti-Panici P, Mancuso S
Int J Cancer. 1998
PubMed ID: 9426687
A mutant E2F-1 transcription factor that affects the phenotype of NIH3T3 fibroblasts inefficiency associates with cyclin A-cdk2.
Jordan-Sciutto KL, Hall DJ
Biochem Cell Biol. 1998
PubMed ID: 9666304
Control of cell cycle gene expression in bone development and during c-Fos-induced osteosarcoma formation.
Sunters A, McCluskey J, Grigoriadis AE
Dev Genet. 1998
PubMed ID: 9664690
Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation.
Deed RW, Hara E, Atherton GT, Peters G, Norton JD
Mol Cell Biol. 1997
PubMed ID: 9372912
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells.
Poon RY, Chau MS, Yamashita K, Hunter T
Cancer Res. 1997
PubMed ID: 9371520
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.
Zindy F, Soares H, Herzog KH, Morgan J, Sherr CJ, Roussel MF
Cell Growth Differ. 1997
PubMed ID: 9372237
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.
Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA
Nat Struct Biol. 1997
PubMed ID: 9334743
Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylation.
Knudsen ES, Wang JY
Mol Cell Biol. 1997
PubMed ID: 9315635
A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity.
Nekhai S, Shukla RR, Kumar A
J Virol. 1997
PubMed ID: 9311822
Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.
Li CJ, Ueda Y, Shi B, Borodyansky L, Huang L, Li YZ, Pardee AB
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9223324
BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN
Oncogene. 1997
PubMed ID: 9244350
Specific regulation of E2F family members by cyclin-dependent kinases.
Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L
Mol Cell Biol. 1997
PubMed ID: 9199321
Cyclin E-CDK2 is a regulator of p27Kip1.
Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE
Genes Dev. 1997
PubMed ID: 9192873
Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes.
Lacy S, Whyte P
Oncogene. 1997
PubMed ID: 9188854
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases.
Zarkowska T, Mittnacht S
J Biol Chem. 1997
PubMed ID: 9139732
Interaction between Cdc37 and Cdk4 in human cells.
Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, Draetta GF, Gyuris J
Oncogene. 1997
PubMed ID: 9150368
Cell cycle control with minimal participation of Cdk2 in a murine fibrosarcoma clone cultured in protein-free medium.
Dobashi Y, Chigira M, Shoji M, Wakata Y, Kitagawa M, Tamauchi H, Akiyama T, Kameya T
Biochem Biophys Res Commun. 1997
PubMed ID: 9126324
Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells.
Sweeney KJ, Sarcevic B, Sutherland RL, Musgrove EA
Oncogene. 1997
PubMed ID: 9178893
Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling.
Zhang Q, Ahuja HS, Zakeri ZF, Wolgemuth DJ
Dev Biol. 1997
PubMed ID: 9126296
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW
Cell. 1997
PubMed ID: 9054499
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.
Yang R, Morosetti R, Koeffler HP
Cancer Res. 1997
PubMed ID: 9041194
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Meijer L, Borgne A, Mulner O, Chong JP, Blow JJ, Inagaki N, Inagaki M, Delcros JG, Moulinoux JP
Eur J Biochem. 1997
PubMed ID: 9030781
Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors.
Hara E, Hall M, Peters G
EMBO J. 1997
PubMed ID: 9029153
Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system.
Krude T, Jackman M, Pines J, Laskey RA
Cell. 1997
PubMed ID: 9019396
Inhibition of myogenesis by multiple cyclin-Cdk complexes. Coordinate regulation of myogenesis and cell cycle activity at the level of E2F.
Guo K, Walsh K
J Biol Chem. 1997
PubMed ID: 8995365
Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.
Ahuja HS, Zhu Y, Zakeri Z
Dev Genet. 1997
PubMed ID: 9438340
High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design.
Schulze-Gahmen U, De Bondt HL, Kim SH
J Med Chem. 1996
PubMed ID: 8917641
Temporal patterns of gene expression of G1-S cyclins and cdks during the first and second mitotic cell cycles in mouse embryos.
Moore GD, Ayabe T, Kopf GS, Schultz RM
Mol Reprod Dev. 1996
PubMed ID: 8916036
Interaction of cyclin-dependent kinase 2 and the Lyn tyrosine kinase in cells treated with 1-beta-D-arabinofuranosylcytosine.
Yuan ZM, Huang Y, Kraeft SK, Chen LB, Kharbanda S, Kufe D
Oncogene. 1996
PubMed ID: 8806683
Cyclin-binding motifs are essential for the function of p21CIP1.
Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A
Mol Cell Biol. 1996
PubMed ID: 8756624
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
Clurman BE, Sheaff RJ, Thress K, Groudine M, Roberts JM
Genes Dev. 1996
PubMed ID: 8769642
Structural basis of cyclin-dependent kinase activation by phosphorylation.
Russo AA, Jeffrey PD, Pavletich NP
Nat Struct Biol. 1996
PubMed ID: 8756328
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP
Nature. 1996
PubMed ID: 8684460
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, Lee WH
Cancer Res. 1996
PubMed ID: 8764100
D-type cyclin expression is decreased and p21 and p27 CDK inhibitor expression is increased when tsBN462 CCG1/TAFII250 mutant cells arrest in G1 at the restrictive temperature.
Sekiguchi T, Noguchi E, Hayashida T, Nakashima T, Toyoshima H, Nishimoto T, Hunter T
Genes Cells. 1996
PubMed ID: 9078394
Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8692842
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.
Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8692841
Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage.
Poon RY, Jiang W, Toyoshima H, Hunter T
J Biol Chem. 1996
PubMed ID: 8662825
Characterization of the human cyclin-dependent kinase 2 gene. Promoter analysis and gene structure.
Shiffman D, Brooks EE, Brooks AR, Chan CS, Milner PG
J Biol Chem. 1996
PubMed ID: 8647814
Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites.
Knudsen ES, Wang JY
J Biol Chem. 1996
PubMed ID: 8626527
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.
De Azevedo WF, Mueller-Dieckmann HJ, Schulze-Gahmen U, Worland PJ, Sausville E, Kim SH
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8610110
Role of cyclin A and p27 in anti-IgM induced G1 growth arrest of murine B-cell lymphomas.
Ezhevsky SA, Toyoshima H, Hunter T, Scott DW
Mol Biol Cell. 1996
PubMed ID: 8730099
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Bourne Y, Watson MH, Hickey MJ, Holmes W, Rocque W, Reed SI, Tainer JA
Cell. 1996
PubMed ID: 8601310
Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25.
Xu X, Burke SP
J Biol Chem. 1996
PubMed ID: 8617791
Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein.
Fromm L, Overbeek PA
Oncogene. 1996
PubMed ID: 8552401
A distinct cyclin A is expressed in germ cells in the mouse.
Sweeney C, Murphy M, Kubelka M, Ravnik SE, Hawkins CF, Wolgemuth DJ, Carrington M
Development. 1996
PubMed ID: 8565853
Cdk family genes are expressed not only in dividing but also in terminally differentiated mouse germ cells, suggesting their possible function during both cell division and differentiation.
Rhee K, Wolgemuth DJ
Dev Dyn. 1995
PubMed ID: 8601034
Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin.
Poon RY, Hunter T
Science. 1995
PubMed ID: 7569954
Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells.
Hosokawa Y, Yang M, Kaneko S, Tanaka M, Nakashima K
Biochem Mol Biol Int. 1995
PubMed ID: 8673024
Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
Poon RY, Toyoshima H, Hunter T
Mol Biol Cell. 1995
PubMed ID: 8534916
14-3-3 proteins associate with cdc25 phosphatases.
Conklin DS, Galaktionov K, Beach D
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7644510
Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.
Aprelikova O, Xiong Y, Liu ET
J Biol Chem. 1995
PubMed ID: 7629134
Differential regulation of p34cdc2 and p33cdk2 by transforming growth factor-beta 1 in murine mammary epithelial cells.
Fautsch MP, Eblen ST, Anders RA, Burnette RJ, Leof EB
J Cell Biochem. 1995
PubMed ID: 7593274
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massagué J, Pavletich NP
Nature. 1995
PubMed ID: 7630397
Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.
Beijersbergen RL, Carlée L, Kerkhoven RM, Bernards R
Genes Dev. 1995
PubMed ID: 7797074
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
Watanabe N, Broome M, Hunter T
EMBO J. 1995
PubMed ID: 7743995
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.
Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB
Science. 1995
PubMed ID: 7716549
Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development.
Said TK, Medina D
Carcinogenesis. 1995
PubMed ID: 7728962
A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen.
Warbrick E, Lane DP, Glover DM, Cox LS
Curr Biol. 1995
PubMed ID: 7780738
A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly transformed rat thyroid (FRTL-Tc) cell line.
Kotani S, Endo T, Kitagawa M, Higashi H, Onaya T
Oncogene. 1995
PubMed ID: 7862443
Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.
Desai D, Wessling HC, Fisher RP, Morgan DO
Mol Cell Biol. 1995
PubMed ID: 7799941
Cyclin D1/cdk2 kinase is present in a G1 phase-specific protein complex Yi1 that binds to the mouse thymidine kinase gene promoter.
Dou QP, Molnar G, Pardee AB
Biochem Biophys Res Commun. 1994
PubMed ID: 7811275
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H
Mol Cell Biol. 1994
PubMed ID: 7969176
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.
Toyoshima H, Hunter T
Cell. 1994
PubMed ID: 8033213
Microsomal localization of cyclin A and cdk2 in proliferating rat liver cells.
Castro A, Jaumot M, Vergés M, Agell N, Bachs O
Biochem Biophys Res Commun. 1994
PubMed ID: 8024548
Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes.
Kim YH, Buchholz MA, Chrest FJ, Nordin AA
J Immunol. 1994
PubMed ID: 8157956
KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.
Hannon GJ, Casso D, Beach D
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8127873
Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.
Demetrick DJ, Zhang H, Beach DH
Cytogenet Cell Genet. 1994
PubMed ID: 8275715
p21 is a universal inhibitor of cyclin kinases.
Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D
Nature. 1993
PubMed ID: 8259214
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.
Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K
J Virol. 1993
PubMed ID: 8230483
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ
Cell. 1993
PubMed ID: 8242751
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.
Gyuris J, Golemis E, Chertkov H, Brent R
Cell. 1993
PubMed ID: 8242750
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.
Xiong Y, Zhang H, Beach D
Genes Dev. 1993
PubMed ID: 8101826
Crystal structure of cyclin-dependent kinase 2.
De Bondt HL, Rosenblatt J, Jancarik J, Jones HD, Morgan DO, Kim SH
Nature. 1993
PubMed ID: 8510751
Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.
Sebastian B, Kakizuka A, Hunter T
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8475101
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW
J Biol Chem. 1993
PubMed ID: 8463339
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
Gu Y, Rosenblatt J, Morgan DO
EMBO J. 1992
PubMed ID: 1396589
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle.
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM
Science. 1992
PubMed ID: 1388288
Cyclin A is required at two points in the human cell cycle.
Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G
EMBO J. 1992
PubMed ID: 1312467
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.
Ninomiya-Tsuji J, Nomoto S, Yasuda H, Reed SI, Matsumoto K
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1717994
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
Tsai LH, Harlow E, Meyerson M
Nature. 1991
PubMed ID: 1653904
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
Elledge SJ, Spottswood MR
EMBO J. 1991
PubMed ID: 1714386

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	1017	12566	362817
EnsEMBL Gene(s)	ENSG00000123374	ENSMUSG00000025358	ENSRNOG00000006469
Unigene	Hs.19192	Mm.111326	Rn.104460
Homologene	CDK2	Cdk2	Cdk2
OMIM	116953	N/A	N/A
GeneCards	CDK2	N/A	N/A
Beta Cell Genomics	DT.313922 DT.92441495 DT.95327485	DT.101388442 DT.490287 DT.55237224 DT.91566446 DT.97346272 DT.97382962	N/A
Reactome	P24941	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	1017	12566	362817

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
CDK2	CHAF1A	HPRD, MINT, BioGRID	empirical	16826239
CDK2	CDK2	HPRD, IntAct	empirical	17192257 17353931
CDK2	CDK6	BioGRID	empirical	10934208
CDK2	CDK7	HPRD, BioGRID	empirical	11113184 8692842
CDK2	CDKN1A	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	12839982 16962592 16765349 15232106 9284049 15890360 17418410 9840943 8756624 8641969 10878006 12417722 8242751 9858587 18729080 20102411 15707957 15647383 15557281 20587660
CDK2	CDKN1B	HPRD, MINT, IntAct, BioGRID	empirical	12972555 9192873 17254966 16326706 17053782 17254967 15890360 17418410 15619620 12417722 15355997 12529437 15647383 15557281
CDK2	CDKN3	HPRD, MINT, IntAct, BioGRID	empirical	12745075 11463386 8242751 8242750 7569954 9840943 8127873
CDK2	CDX2	HPRD	empirical	16027724
CDK2	CEBPA	HPRD, BioGRID	empirical	11684017
CDK2	CEBPG	BioGRID	empirical	12757710
CDK2	MAPRE2	IntAct	empirical	21988832
CDK2	CDC37	HPRD	empirical	9150368
CDK2	PTP4A3	IntAct, BioGRID	empirical	17353931
CDK2	UHRF2	HPRD, IntAct, BioGRID	empirical	15178429 21952639
CDK2	CKS1B	HPRD, MINT, IntAct, BioGRID	empirical	8601310 12140288 9840943 17409098
CDK2	EP300	HPRD, MINT, BioGRID	empirical	10330164
CDK2	EPB41	IntAct, BioGRID	empirical	17353931
CDK2	FBL	IntAct, BioGRID	empirical	17353931
CDK2	FABP5	IntAct	empirical	17353931
CDK2	FEN1	HPRD, BioGRID	empirical	12853968
CDK2	CNKSR2	IntAct	empirical	17353931
CDK2	FOXM1	HPRD	empirical	15024056
CDK2	CDK20	HPRD	empirical	14597612
CDK2	PHLDA3	IntAct	empirical	21988832
CDK2	SPDYA	HPRD, BioGRID	empirical	11980914 12839962 12972555
CDK2	ABL1	IntAct	empirical	17254966
CDK2	XRCC6	BioGRID	empirical	15159402
CDK2	PABPC1	IntAct	empirical	17353931
CDK2	POLL	HPRD	empirical	16174846
CDK2	GOT2	IntAct	empirical	17353931
CDK2	CNOT7	HPRD, BioGRID	empirical	10602502
CDK2	HIST1H1B	HPRD	empirical	7629134
CDK2	HIST1H1A	BioGRID	empirical	17293600
CDK2	BIRC5	BioGRID	empirical	11069302
CDK2	ID2	HPRD	empirical	9029153
CDK2	ID3	HPRD	empirical	9372912
CDK2	IL15RA	IntAct	empirical	21988832
CDK2	GSTK1	IntAct	empirical	17353931
CDK2	KRAS	BioGRID	empirical	22045811
CDK2	INCA1	BioGRID	empirical	15159402
CDK2	LYN	HPRD, BioGRID	empirical	10432313 8806683
CDK2	SMAD3	HPRD	empirical	15241418
CDK2	MCM3	HPRD, MINT, IntAct	empirical	15232106
CDK2	MCM4	HPRD, BioGRID	empirical	16519687 16517729 10748114
CDK2	MGMT	BioGRID	empirical	16226712
CDK2	MNDA	HPRD	empirical	16458891
CDK2	MSN	IntAct	empirical	17353931
CDK2	MTHFD1	IntAct	empirical	17353931
CDK2	MYBL2	HPRD, BioGRID	empirical	9840932 10095772 10593981 11264176
CDK2	MYH8	IntAct	empirical	17353931
CDK2	MYOD1	HPRD	empirical	9710583
CDK2	ATIC	IntAct	empirical	17353931
CDK2	ATM	Reactome	predicted
CDK2	NEDD8	IntAct, BioGRID	empirical	17353931
CDK2	NFYA	HPRD	empirical	12857729
CDK2	NOV	BioGRID	empirical	15647383
CDK2	NPM1	HPRD, BioGRID	empirical	11278991 16376875
CDK2	WRAP73	IntAct, BioGRID	empirical	17353931
CDK2	ORC1	HPRD, IntAct, BioGRID	empirical	11931757
CDK2	ORC2	HPRD, MINT, IntAct, BioGRID	empirical	15232106 11931757
CDK2	PEBP1	IntAct	empirical	17353931
CDK2	PCNA	HPRD, BioGRID	empirical	10930425
CDK2	FZR1	HPRD	empirical	12560341
CDK2	CCRL1	IntAct	empirical	21988832
CDK2	PML	IntAct	empirical	21840486
CDK2	POLA1	HPRD, BioGRID	empirical	11259605 10877824
CDK2	POLD1	HPRD, MIPS	empirical	9545286
CDK2	POLD2	HPRD	empirical	16479163
CDK2	RRN3	BioGRID	empirical	15004009
CDK2	PPM1B	HPRD, BioGRID	empirical	10934208
CDK2	PPP1CA	IntAct	empirical	17274640
CDK2	PPP1CC	IntAct	empirical	17274640
CDK2	PPP2CA	BioGRID	empirical	10934208
CDK2	BTBD2	IntAct	empirical	21988832
CDK2	RADIL	IntAct, BioGRID	empirical	17353931
CDK2	PRKAR1A	HPRD	empirical	16582606
CDK2	PRKCH	HPRD, BioGRID	empirical	11175348
CDK2	BCCIP	BioGRID	empirical	10878006
CDK2	NPDC1	HPRD, BioGRID	empirical	11042687
CDK2	PTHLH	HPRD	empirical	10373465
CDK2	PTMA	HPRD	empirical	11310559
CDK2	PTPN2	HPRD	empirical	15030318
CDK2	PURA	BioGRID	empirical	15707957
CDK2	RB1	HPRD, IntAct, BioGRID	empirical	8756624 9315635 9139732 8626527 10207050 16326706 20871633 10938106 19225156 15003538
CDK2	RBL1	HPRD	empirical	8230483 11884610
CDK2	RBL2	HPRD, IntAct, BioGRID	empirical	9188854 17531812 9891079
CDK2	RBM4	BioGRID	empirical	15159402
CDK2	CCND1	IntAct	empirical	16413469 9840943
CDK2	BCL2	HPRD	empirical	15619620
CDK2	REL	BioGRID	empirical	9731206
CDK2	RPS16	IntAct	empirical	17353931
CDK2	SORT1	IntAct	empirical	17353931
CDK2	S100A8	IntAct	empirical	17353931
CDK2	TSPYL2	HPRD, BioGRID	empirical	11395479
CDK2	FAM113A	IntAct, BioGRID	empirical	17353931
CDK2	SKP2	HPRD, BioGRID	empirical	10386600 15355997 10559858 9858587 19686743
CDK2	CDK15	IntAct, BioGRID	empirical	17353931
CDK2	SLC2A4	IntAct	empirical	16396496
CDK2	SP1	BioGRID	empirical	11598016
CDK2	BRCA1	HPRD, BioGRID	empirical	10373534 8764100 9244350
CDK2	BRCA2	HPRD	empirical	15800651 15800615
CDK2	CNTN2	BioGRID	empirical	16822311
CDK2	TBCA	IntAct	empirical	17353931
CDK2	TP53	HPRD, BioGRID	empirical	10884347 12064478 10747897 10348343
CDK2	TP73	HPRD	empirical	12676926
CDK2	TSSC1	IntAct	empirical	17353931
CDK2	HIRA	HPRD	empirical	11238922
CDK2	UBC	BioGRID	empirical	21890473 18781797 21139048 21906983
CDK2	UBE2A	HPRD, BioGRID	empirical	11953320
CDK2	UBTF	HPRD	empirical	11698641 10202152
CDK2	VHL	IntAct, BioGRID	empirical	17353931
CDK2	WEE1	HPRD, Reactome	empirical	7743995
CDK2	NAA25	IntAct, BioGRID	empirical	17353931
CDK2	CDK2AP1	HPRD, BioGRID	empirical	10938106
CDK2	COIL	HPRD	empirical	11102515
CDK2	CDT1	HPRD, IntAct, BioGRID	empirical	14993212 15004027
CDK2	CHAF1B	HPRD	empirical	10938080
CDK2	CDC7	HPRD	empirical	10846177
CDK2	CASP4	IntAct, BioGRID	empirical	17353931
CDK2	TAGLN2	IntAct	empirical	17353931
CDK2	OGT	IntAct, BioGRID	empirical	17353931
CDK2	IKBKG	BioGRID	empirical	20098747
CDK2	CCNB3	HPRD, IntAct, BioGRID	empirical	12185076 14681455
CDK2	CCNK	HPRD	empirical	9632813 10574912
CDK2	TSC22D1	IntAct, BioGRID	empirical	17353931
CDK2	KAT2B	BioGRID	empirical	19483727
CDK2	CCNA2	HPRD, IntAct, BioGRID	empirical	11907280 10924145 8684460 8756328 11141566 12244298 12941338 15189033 15239650 17254966 15890360 19592082 14681455 12853968 15647383 15557281 19483727 20733051
CDK2	CCNA1	HPRD, IntAct, BioGRID	empirical	9041194 10559988 16777603 14681455 8565853 11264176 16159883 10652300 19423708
CDK2	CCNB1	BioGRID	empirical	9891079 20733051
CDK2	CCND2	IntAct	empirical	9840943
CDK2	CCNE1	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	1388288 14536078 10330164 17254967 9840943 19592082 21092281 8756624 14681455 16223725 12839982 9891079 15004009 12529437 10827081 15557281 20587660 8769642 20837141 7799941 7629134
CDK2	CCNH	HPRD, IntAct	empirical	9464540 9840943 8521818
CDK2	UBE2M	IntAct, BioGRID	empirical	17353931
CDK2	PRC1	HPRD	empirical	9885575
CDK2	CCNB2	HPRD, MINT, IntAct	empirical	15232106
CDK2	CCNE2	HPRD, IntAct, BioGRID, Reactome	empirical	9858585 15232106 9840943 14681455 7799941 7629134
CDK2	C12orf65	IntAct	empirical	21988832
CDK2	CABLES1	Reactome	predicted
CDK2	MS4A3	BioGRID	empirical	11781350
CDK2	CCP110	HPRD	empirical	12361598
CDK2	KIAA0101	BioGRID	empirical	21628590
CDK2	CDC5L	BioGRID	empirical	10827081
CDK2	CDC6	HPRD, BioGRID	empirical	9889196 10339564 9566895
CDK2	CDC25A	HPRD, BioGRID	empirical	8617791 12388094
CDK2	CDC25B	IntAct, BioGRID	empirical	9840943 7644510