Home NR1H3
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(Human) GRCh37 - chr11:47269851..47290584 (20.73 kb) View in Genome Browser
(Mouse) NCBIM37 - chr2:91024218..91042991 (18.77 kb) View in Genome Browser
(Rat) RGSC3.4 - chr3:75542180..75550800 (8.62 kb) View in Genome Browser
HaemAtlas Expression Table for NR1H3:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for NR1H3:The NR1H3 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| NR1H3 | PPARGC1A | BioGRID | empirical | 20211142 |
| NR1H3 | PPARGC1B | BioGRID | empirical | 20211142 |
| NR1H3 | NCOA6 | HPRD, BioGRID | empirical | 12724417 15604093 |
| NR1H3 | FOXO3 | HPRD, BioGRID | empirical | 15604093 |
| NR1H3 | SIRT1 | HPRD, IntAct, BioGRID | empirical | 17936707 |
| NR1H3 | SS18L1 | BioGRID | empirical | 20211142 |
| NR1H3 | ING3 | HPRD | empirical | 15604093 |
| NR1H3 | PPARA | BioGRID | empirical | 8621574 |
| NR1H3 | MED1 | Reactome | predicted | 10542397 10235266 16751179 15896744 15175151 11865025 9653119 |
| NR1H3 | TMEM161A | HPRD, BioGRID | empirical | 15604093 |
| NR1H3 | MSTO1 | IntAct | empirical | 21988832 |
| NR1H3 | BARD1 | BioGRID | empirical | 19164445 |
| NR1H3 | RARA | HPRD | empirical | 10022764 |
| NR1H3 | RXRA | HPRD, BioGRID | empirical | 9013544 12117567 15604093 8621574 20211142 |
| NR1H3 | RXRB | HPRD, BioGRID | empirical | 15604093 |
| NR1H3 | RXRG | HPRD, BioGRID | empirical | 15604093 20211142 |
| NR1H3 | SRC | BioGRID | empirical | 15604093 |
| NR1H3 | SYT1 | HPRD | empirical | 16143103 |
| NR1H3 | UBC | BioGRID | empirical | 17936707 |
| NR1H3 | ZNF227 | BioGRID | empirical | 20211142 |
| NR1H3 | ZXDC | BioGRID | empirical | 15604093 |
| NR1H3 | NCOA3 | HPRD | empirical | 15604093 |
| NR1H3 | NRIP1 | HPRD, BioGRID | empirical | 10022764 15604093 |
| NR1H3 | LZTR1 | BioGRID | empirical | 20211142 |
| NR1H3 | NR0B2 | HPRD, BioGRID | empirical | 12198243 |
| NR1H3 | EIF3I | BioGRID | empirical | 15604093 |
| NR1H3 | ACTN1 | HPRD, BioGRID | empirical | 15604093 |
| NR1H3 | EDF1 | HPRD, IntAct, BioGRID | empirical | 12040021 |
| NR1H3 | KAT2B | BioGRID | empirical | 15604093 |
| NR1H3 | NCOR1 | HPRD, BioGRID | empirical | 15604093 12663743 |
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Type 1 Diabetes Publications: 8
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Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes.
Ketterer C, Müssig K, Machicao F, Stefan N, Fritsche A, Häring HU, Staiger H
J Mol Med. 2010
PubMed ID: 21042792
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ELEVATED INSULIN SECRETION FROM LIVER X RECEPTOR-ACTIVATED PANCREATIC BETA-CELLS INVOLVES INCREASED DE NOVO LIPID SYNTHESIS AND TRIACYLGLYCERIDE TURNOVER.
Green CD, Jump DB, Olson LK
Endocrinology. 2009
PubMed ID: 19228891
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Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.
Hellemans KH, Hannaert JC, Denys B, Steffensen KR, Raemdonck C, Martens GA, Van Veldhoven PP, Gustafsson JA, Pipeleers D
PLoS One. 2009
PubMed ID: 19787047
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Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest.
Meng ZX, Nie J, Ling JJ, Sun JX, Zhu YX, Gao L, Lv JH, Zhu DY, Sun YJ, Han X
Diabetologia. 2008
PubMed ID: 18949453
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Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells.
Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, Lee KM, Park KG, Lee IK, Kim JB
Diabetes. 2007
PubMed ID: 17369526
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Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.
Helleboid-Chapman A, Helleboid S, Jakel H, Timmerman C, Sergheraert C, Pattou F, Fruchart-Najib J, Fruchart JC
Cell Res. 2006
PubMed ID: 16773041
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LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function.
Gerin I, Dolinsky VW, Shackman JG, Kennedy RT, Chiang SH, Burant CF, Steffensen KR, Gustafsson JA, MacDougald OA
J Biol Chem. 2005
PubMed ID: 15831500
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Liver X receptor activation stimulates insulin secretion via modulation of glucose and lipid metabolism in pancreatic beta-cells.
Efanov AM, Sewing S, Bokvist K, Gromada J
Diabetes. 2004
PubMed ID: 15561926
Publications: 365
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The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
Marwarha G, Rhen T, Schommer T, Ghribi O
J Neurochem. 2011
PubMed ID: 21951066
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The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.
Nelson ER, DuSell CD, Wang X, Howe MK, Evans G, Michalek RD, Umetani M, Rathmell JC, Khosla S, Gesty-Palmer D, McDonnell DP
Endocrinology. 2011
PubMed ID: 21933863
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Genetic variation in liver X receptor alpha and risk of ischemic vascular disease in the general population.
Stender S, Frikke-Schmidt R, Anestis A, Kardassis D, Sethi AA, Nordestgaard BG, Tybjærg-Hansen A
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21903943
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Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.
Saini SP, Zhang B, Niu Y, Jiang M, Gao J, Zhai Y, Hoon Lee J, Uppal H, Tian H, Tortorici MA, Poloyac SM, Qin W, Venkataramanan R, Xie W
Hepatology. 2011
PubMed ID: 21898498
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Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels.
Cui W, Sun Y, Wang Z, Xu C, Xu L, Wang F, Chen Z, Peng Y, Li R
Neurochem Res. 2011
PubMed ID: 21630010
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Activation of liver X receptor (LXR) inhibits receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation in an LXRβ-dependent mechanism.
Remen KM, Henning P, Lerner UH, Gustafsson JÅ, Andersson G
J Biol Chem. 2011
PubMed ID: 21784849
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High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats.
Li D, Wang X, Ren W, Ren J, Lan X, Wang F, Li H, Zhang F, Han Y, Song T, Holmdahl R, Lu S
Mol Cell Endocrinol. 2011
PubMed ID: 21763752
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Liver X receptor-activating ligands modulate renal and intestinal sodium-phosphate transporters.
Caldas YA, Giral H, Cortázar MA, Sutherland E, Okamura K, Blaine J, Sorribas V, Koepsell H, Levi M
Kidney Int. 2011
PubMed ID: 21677638
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LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.
Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA, Pineda-Torra I
Circ Res. 2011
PubMed ID: 21757649
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PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC
Biochem J. 2011
PubMed ID: 21609322
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Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice.
Korach-André M, Archer A, Gabbi C, Barros RP, Pedrelli M, Steffensen KR, Pettersson AT, Laurencikiene J, Parini P, Gustafsson JÅ
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21521718
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Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.
Makoukji J, Shackleford G, Meffre D, Grenier J, Liere P, Lobaccaro JM, Schumacher M, Massaad C
J Neurosci. 2011
PubMed ID: 21715627
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation.
Köröskényi K, Duró E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z
J Immunol. 2011
PubMed ID: 21593381
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Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study.
Price ET, Pacanowski MA, Martin MA, Cooper-DeHoff RM, Pepine CJ, Zineh I, Johnson JA
Pharmacogenet Genomics. 2011
PubMed ID: 21562465
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Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.
Nakaya K, Tohyama J, Naik SU, Tanigawa H, MacPhee C, Billheimer JT, Rader DJ
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21441141
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Oxygenated derivatives of cholesterol promote hepatitis B virus gene expression through nuclear receptor LXRα activation.
Kim HY, Cho HK, Kim HH, Cheong J
Virus Res. 2011
PubMed ID: 21440016
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Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT
J Neurosci. 2011
PubMed ID: 21562267
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Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production.
Ng SS, Chang TH, Tailor P, Ozato K, Kino T
FEBS Lett. 2011
PubMed ID: 21492741
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Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.
Scotti E, Hong C, Yoshinaga Y, Tu Y, Hu Y, Zelcer N, Boyadjian R, de Jong PJ, Young SG, Fong LG, Tontonoz P
Mol Cell Biol. 2011
PubMed ID: 21343340
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Associations between common genetic polymorphisms in the liver X receptor alpha and its target genes with the serum HDL-cholesterol concentration in adolescents of the HELENA Study.
Legry V, Bokor S, Beghin L, Galfo M, Gonzalez-Gross M, Molnar D, Moreno LA, Amouyel P, Dallongeville J, Meirhaeghe A, HELENA Study Group
Atherosclerosis. 2011
PubMed ID: 21316679
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Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes.
Shen Q, Bai Y, Chang KC, Wang Y, Burris TP, Freedman LP, Thompson CC, Nagpal S
J Biol Chem. 2011
PubMed ID: 21349840
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Liver X receptor-α/β expression ratio is increased in ACTH-secreting pituitary adenomas.
Hashimoto K, Matsumoto S, Ishida E, Miura A, Horiguchi K, Ozawa A, Shibusawa N, Satoh T, Yamada M, Yamada S, Mori M
Neurosci Lett. 2011
PubMed ID: 21356276
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Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.
Pascual-García M, Carbó JM, León T, Matalonga J, Out R, Van Berkel T, Sarrias MR, Lozano F, Celada A, Valledor AF
J Immunol. 2011
PubMed ID: 21398609
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Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways.
Chinetti-Gbaguidi G, Baron M, Bouhlel MA, Vanhoutte J, Copin C, Sebti Y, Derudas B, Mayi T, Bories G, Tailleux A, Haulon S, Zawadzki C, Jude B, Staels B
Circ Res. 2011
PubMed ID: 21350215
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MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation.
Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, Xie W
Mol Endocrinol. 2011
PubMed ID: 21310851
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CIDEA interacts with liver X receptors in white fat cells.
Kulyté A, Pettersson AT, Antonson P, Stenson BM, Langin D, Gustafsson JA, Staels B, Rydén M, Arner P, Laurencikiene J
FEBS Lett. 2011
PubMed ID: 21315073
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Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.
Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P
J Lipid Res. 2011
PubMed ID: 21187453
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Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.
Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P
Gastroenterology. 2011
PubMed ID: 21134374
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LXR-α selectively reprogrammes cancer cells to enter into apoptosis.
Mehrotra A, Kaul D, Joshi K
Mol Cell Biochem. 2011
PubMed ID: 21125317
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LXR activation prevents exhaustive exercise-induced hypoglycaemia and spares muscle glycogen but does not enhance running endurance in untrained rats.
Baranowski M, Zabielski P, Błachnio-Zabielska AU, Harasiuk D, Górski J
Acta Physiol (Oxf). 2011
PubMed ID: 20887359
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Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation.
Cui G, Qin X, Wu L, Zhang Y, Sheng X, Yu Q, Sheng H, Xi B, Zhang JZ, Zang YQ
J Clin Invest. 2011
PubMed ID: 21266776
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Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease.
Andersen V, Christensen J, Ernst A, Jacobsen BA, Tjønneland A, Krarup HB, Vogel U
World J Gastroenterol. 2011
PubMed ID: 21245992
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LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL
J Clin Invest. 2011
PubMed ID: 21123945
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The role of hepatic liver X receptor α- and sterol regulatory element binding protein-1c-mediated lipid disorder in the pathogenesis of non-alcoholic steatohepatitis in rats.
Ai ZL, Zhu CH, Min M, Wang J, Lan CH, Fan LL, Sun WJ, Chen DF
J Int Med Res. 2011
PubMed ID: 21986124
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Decreased expression of liver X receptor-α in macrophages infected with Chlamydia pneumoniae in human atherosclerotic arteries in situ.
Bobryshev YV, Orekhov AN, Killingsworth MC, Lu J
J Innate Immun. 2011
PubMed ID: 21625070
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1.
Cheng LC, Su KH, Kou YR, Shyue SK, Ching LC, Yu YB, Wu YL, Pan CC, Lee TS
Free Radic Biol Med. 2011
PubMed ID: 21034810
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Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
Gene Expr Patterns. 2011
PubMed ID: 20932939
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Regulation of LPCAT3 by LXR.
Demeure O, Lecerf F, Duby C, Desert C, Ducheix S, Guillou H, Lagarrigue S
Gene. 2011
PubMed ID: 20837115
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Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.
Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, Robins SJ, Schaefer EJ, Brousseau ME
J Lipid Res. 2010
PubMed ID: 20855565
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Carbohydrate-response-element-binding protein (ChREBP) and not the liver X receptor α (LXRα) mediates elevated hepatic lipogenic gene expression in a mouse model of glycogen storage disease type 1.
Grefhorst A, Schreurs M, Oosterveer MH, Cortés VA, Havinga R, Herling AW, Reijngoud DJ, Groen AK, Kuipers F
Biochem J. 2010
PubMed ID: 20854262
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FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells.
Liu X, Qiao A, Ke Y, Kong X, Liang J, Wang R, Ouyang X, Zuo J, Chang Y, Fang F
FEBS Lett. 2010
PubMed ID: 20868688
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Thyroid hormone receptor beta (TRbeta) and liver X receptor (LXR) regulate carbohydrate-response element-binding protein (ChREBP) expression in a tissue-selective manner.
Gauthier K, Billon C, Bissler M, Beylot M, Lobaccaro JM, Vanacker JM, Samarut J
J Biol Chem. 2010
PubMed ID: 20615868
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Activation of LXRα induces lipogenesis in HaCaT cells.
Hong I, Rho HS, Kim DH, Lee MO
Arch Pharm Res. 2010
PubMed ID: 20945144
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Expression of liver X receptors in pregnancies complicated by preeclampsia.
Weedon-Fekjær MS, Johnsen GM, Anthonisen EH, Sugulle M, Nebb HI, Duttaroy AK, Staff AC
Placenta. 2010
PubMed ID: 20655109
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Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages.
Lee TS, Pan CC, Peng CC, Kou YR, Chen CY, Ching LC, Tsai TH, Chen SF, Lyu PC, Shyue SK
J Cell Biochem. 2010
PubMed ID: 20506155
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LXRalpha regulates human CETP expression in vitro and in transgenic mice.
Honzumi S, Shima A, Hiroshima A, Koieyama T, Ubukata N, Terasaka N
Atherosclerosis. 2010
PubMed ID: 20494359
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Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/- female mice.
Gabbi C, Kim HJ, Barros R, Korach-Andrè M, Warner M, Gustafsson JA
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20679224
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Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis.
Lo Sasso G, Murzilli S, Salvatore L, D'Errico I, Petruzzelli M, Conca P, Jiang ZY, Calabresi L, Parini P, Moschetta A
Cell Metab. 2010
PubMed ID: 20674863
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Nuclear receptors in leydig cell gene expression and function.
Martin LJ, Tremblay JJ
Biol Reprod. 2010
PubMed ID: 20375256
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LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration.
Walcher D, Vasic D, Heinz P, Bach H, Durst R, Hausauer A, Hombach V, Marx N
Basic Res Cardiol. 2010
PubMed ID: 20364260
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Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells.
Weedon-Fekjaer MS, Dalen KT, Solaas K, Staff AC, Duttaroy AK, Nebb HI
J Lipid Res. 2010
PubMed ID: 20219900
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The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.
Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, Boyadjian R, Rodenburg KW, Foley E, Korhonen L, Lindholm D, Nimpf J, van Berkel TJ, Tontonoz P, Zelcer N
J Biol Chem. 2010
PubMed ID: 20427281
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Activation of liver X receptor sensitizes human dendritic cells to inflammatory stimuli.
Töröcsik D, Baráth M, Benko S, Széles L, Dezso B, Póliska S, Hegyi Z, Homolya L, Szatmári I, Lányi A, Nagy L
J Immunol. 2010
PubMed ID: 20410489
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Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.
Pommier AJ, Alves G, Viennois E, Bernard S, Communal Y, Sion B, Marceau G, Damon C, Mouzat K, Caira F, Baron S, Lobaccaro JM
Oncogene. 2010
PubMed ID: 20190811
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Non-redundant roles for LXRalpha and LXRbeta in atherosclerosis susceptibility in low density lipoprotein receptor knockout mice.
Bischoff ED, Daige CL, Petrowski M, Dedman H, Pattison J, Juliano J, Li AC, Schulman IG
J Lipid Res. 2010
PubMed ID: 20388921
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Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation.
Yeong P, Ning Y, Xu Y, Li X, Yin L
Biochim Biophys Acta. 2010
PubMed ID: 20139031
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Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
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Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
Matsushita K, Morello F, Wu Y, Zhang L, Iwanaga S, Pratt RE, Dzau VJ
J Biol Chem. 2010
PubMed ID: 20118482
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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Activation of liver X receptor-alpha reduces activation of the renal and cardiac renin-angiotensin-aldosterone system.
Kuipers I, van der Harst P, Kuipers F, van Genne L, Goris M, Lehtonen JY, van Veldhuisen DJ, van Gilst WH, de Boer RA
Lab Invest. 2010
PubMed ID: 20125084
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Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo.
Yasuda T, Grillot D, Billheimer JT, Briand F, Delerive P, Huet S, Rader DJ
Arterioscler Thromb Vasc Biol. 2010
PubMed ID: 20110577
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The activation of liver X receptors inhibits toll-like receptor-9-induced foam cell formation.
Sorrentino R, Morello S, Chen S, Bonavita E, Pinto A
J Cell Physiol. 2010
PubMed ID: 20049870
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Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis.
Nedumaran B, Kim GS, Hong S, Yoon YS, Kim YH, Lee CH, Lee YC, Koo SH, Choi HS
J Biol Chem. 2010
PubMed ID: 20080977
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An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
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LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux.
Hessvik NP, Boekschoten MV, Baltzersen MA, Kersten S, Xu X, Andersén H, Rustan AC, Thoresen GH
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 19996385
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Liver X receptor in cholesterol metabolism.
Zhao C, Dahlman-Wright K
J Endocrinol. 2010
PubMed ID: 19837721
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Inhibition of ERK1/2 and activation of liver X receptor synergistically induce macrophage ABCA1 expression and cholesterol efflux.
Zhou X, Yin Z, Guo X, Hajjar DP, Han J
J Biol Chem. 2010
PubMed ID: 20037141
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GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.
Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, Nilsson LM, Parini P, Jänne OA, Gustafsson JA, Steffensen KR, Treuter E
Genes Dev. 2010
PubMed ID: 20159957
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Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis.
Kim YW, Kim YM, Yang YM, Kim TH, Hwang SJ, Lee JR, Kim SC, Kim SG
Free Radic Biol Med. 2010
PubMed ID: 20005944
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The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction.
van Straten EM, Bloks VW, Huijkman NC, Baller JF, Meer H, Lütjohann D, Kuipers F, Plösch T
Am J Physiol Regul Integr Comp Physiol. 2010
PubMed ID: 19889862
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Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice.
Korach-André M, Parini P, Larsson L, Arner A, Steffensen KR, Gustafsson JA
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 19690071
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Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose.
Anthonisen EH, Berven L, Holm S, Nygård M, Nebb HI, Grønning-Wang LM
J Biol Chem. 2010
PubMed ID: 19933273
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LXR deficiency confers increased protection against visceral Leishmania infection in mice.
Bruhn KW, Marathe C, Maretti-Mira AC, Nguyen H, Haskell J, Tran TA, Vanchinathan V, Gaur U, Wilson ME, Tontonoz P, Craft N
PLoS Negl Trop Dis. 2010
PubMed ID: 21103366
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Polymorphisms in NFkB, PXR, LXR and risk of colorectal cancer in a prospective study of Danes.
Andersen V, Christensen J, Overvad K, Tjønneland A, Vogel U
BMC Cancer. 2010
PubMed ID: 20836841
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TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells.
Hu YW, Wang Q, Ma X, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK
J Atheroscler Thromb. 2010
PubMed ID: 20057170
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Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.
Villablanca EJ, Raccosta L, Zhou D, Fontana R, Maggioni D, Negro A, Sanvito F, Ponzoni M, Valentinis B, Bregni M, Prinetti A, Steffensen KR, Sonnino S, Gustafsson JA, Doglioni C, Bordignon C, Traversari C, Russo V
Nat Med. 2010
PubMed ID: 20037595
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Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Cho KH, Kim HJ, Kamanna VS, Vaziri ND
Biochim Biophys Acta. 2010
PubMed ID: 19878707
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Psoriasis: crucial role of LXR-alpha RNomics.
Gupta DS, Kaul D, Kanwar AJ, Parsad D
Genes Immun. 2010
PubMed ID: 19798078
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Liver X receptor expression in human melanocytes, does it have a role in the pathogenesis of vitiligo?
Kumar R, Parsad D, Kaul D, Kanwar A
Exp Dermatol. 2010
PubMed ID: 19645823
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[Role of liver X receptors on cardiomyocyte hypertrophy].
Yin R, Wang MH, Wei YF, Li YQ, Dong YG
Zhonghua Xin Xue Guan Bing Za Zhi. 2009
PubMed ID: 20193185
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
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Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.
Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS
Nat Med. 2009
PubMed ID: 19966778
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N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRalpha.
Howell G, Deng X, Yellaturu C, Park EA, Wilcox HG, Raghow R, Elam MB
Biochim Biophys Acta. 2009
PubMed ID: 19716432
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Liver X receptor β: maintenance of epidermal expression in intrinsic and extrinsic skin aging.
Ford CT, Sherratt MJ, Griffiths CE, Watson RE
Age (Dordr). 2009
PubMed ID: 19697157
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Morello F, Saglio E, Noghero A, Schiavone D, Williams TA, Verhovez A, Bussolino F, Veglio F, Mulatero P
Atherosclerosis. 2009
PubMed ID: 19426978
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Activation of the liver X receptor prevents lipopolysaccharide-induced lung injury.
Gong H, He J, Lee JH, Mallick E, Gao X, Li S, Homanics GE, Xie W
J Biol Chem. 2009
PubMed ID: 19717840
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Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.
Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E
Cell Stem Cell. 2009
PubMed ID: 19796621
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Negative regulation of Hedgehog signaling by liver X receptors.
Kim WK, Meliton V, Park KW, Hong C, Tontonoz P, Niewiadomski P, Waschek JA, Tetradis S, Parhami F
Mol Endocrinol. 2009
PubMed ID: 19608643
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Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling.
Wu S, Yin R, Ernest R, Li Y, Zhelyabovska O, Luo J, Yang Y, Yang Q
Cardiovasc Res. 2009
PubMed ID: 19487338
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Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.
Lee JH, Park SM, Kim OS, Lee CS, Woo JH, Park SJ, Joe EH, Jou I
Mol Cell. 2009
PubMed ID: 19782030
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REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.
Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Sasso GL, Moschetta A, Schibler U
PLoS Biol. 2009
PubMed ID: 19721697
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Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, Díaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, Andujar M, Tontonoz P, Castrillo A
Immunity. 2009
PubMed ID: 19646905
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Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.
Rébé C, Raveneau M, Chevriaux A, Lakomy D, Sberna AL, Costa A, Bessède G, Athias A, Steinmetz E, Lobaccaro JM, Alves G, Menicacci A, Vachenc S, Solary E, Gambert P, Masson D
Circ Res. 2009
PubMed ID: 19628791
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[Expression and significance of liver X receptor-alpha in nonalcoholic fatty liver disease in rats]
Chen J, Zheng RD, Xu CR, Wu WP
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2009
PubMed ID: 20108769
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On the mechanism for PPAR agonists to enhance ABCA1 gene expression.
Ogata M, Tsujita M, Hossain MA, Akita N, Gonzalez FJ, Staels B, Suzuki S, Fukutomi T, Kimura G, Yokoyama S
Atherosclerosis. 2009
PubMed ID: 19201410
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LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.
Zelcer N, Hong C, Boyadjian R, Tontonoz P
Science. 2009
PubMed ID: 19520913
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Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages.
Kim GH, Park K, Yeom SY, Lee KJ, Kim G, Ko J, Rhee DK, Kim YH, Lee HK, Kim HW, Oh GT, Lee KU, Lee JW, Kim SW
Mol Endocrinol. 2009
PubMed ID: 19342446
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Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.
Mouzat K, Volat F, Baron S, Alves G, Pommier AJ, Volle DH, Marceau G, DeHaze A, Déchelotte P, Duggavathi R, Caira F, Lobaccaro JM
Endocrinology. 2009
PubMed ID: 19325005
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Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice.
Korf H, Vander Beken S, Romano M, Steffensen KR, Stijlemans B, Gustafsson JA, Grooten J, Huygen K
J Clin Invest. 2009
PubMed ID: 19436111
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FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes.
Lu R, Ito J, Iwamoto N, Nishimaki-Mogami T, Yokoyama S
J Lipid Res. 2009
PubMed ID: 19229075
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Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver.
Kim TH, Kim H, Park JM, Im SS, Bae JS, Kim MY, Yoon HG, Cha JY, Kim KS, Ahn YH
J Biol Chem. 2009
PubMed ID: 19366697
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GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.
Jakobsson T, Venteclef N, Toresson G, Damdimopoulos AE, Ehrlund A, Lou X, Sanyal S, Steffensen KR, Gustafsson JA, Treuter E
Mol Cell. 2009
PubMed ID: 19481530
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Liver X receptors control IgE expression in B cells.
Heine G, Dahten A, Hilt K, Ernst D, Milovanovic M, Hartmann B, Worm M
J Immunol. 2009
PubMed ID: 19380774
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Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease.
Nakamuta M, Fujino T, Yada R, Yada M, Yasutake K, Yoshimoto T, Harada N, Higuchi N, Kato M, Kohjima M, Taketomi A, Maehara Y, Nakashima M, Kotoh K, Enjoji M
Int J Mol Med. 2009
PubMed ID: 19360318
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Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes.
Kumar N, Wang H, Liu D, Collins S
Int J Obes (Lond). 2009
PubMed ID: 19238156
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LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell specific manner.
Ouvrier A, Cadet R, Vernet P, Lallier B, Chardigny JM, Lobaccaro JM, Drevet JR, Saez F
J Lipid Res. 2009
PubMed ID: 19395734
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[Effect of the liver X receptor agonist on LPS-induced inflammatory response associated factor IRAK-4 and NF-kappaB]
Wang D, Miao CM, Gong JP
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19351492
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Functional genomics of blood cellular LXR-alpha gene in human coronary heart disease.
Dave VP, Kaul D, Sharma Y, Bhattacharya R
J Mol Cell Cardiol. 2009
PubMed ID: 19211025
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Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet.
Hernández Vallejo SJ, Alqub M, Luquet S, Cruciani-Guglielmacci C, Delerive P, Lobaccaro JM, Kalopissis AD, Chambaz J, Rousset M, Lacorte JM
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 19196952
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Liver X receptor ligands suppress ubiquitination and degradation of LXRalpha by displacing BARD1/BRCA1.
Kim KH, Yoon JM, Choi AH, Kim WS, Lee GY, Kim JB
Mol Endocrinol. 2009
PubMed ID: 19164445
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Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma.
Na TY, Shin YK, Roh KJ, Kang SA, Hong I, Oh SJ, Seong JK, Park CK, Choi YL, Lee MO
Hepatology. 2009
PubMed ID: 19105208
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IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.
Hao XR, Cao DL, Hu YW, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK
Atherosclerosis. 2009
PubMed ID: 18789440
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Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y
J Biol Chem. 2009
PubMed ID: 19119143
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Expression of liver X receptor alpha and lipid metabolism in granulocyte-macrophage colony-stimulating factor-induced human monocyte-derived macrophage.
Kazawa T, Kawasaki T, Sakamoto A, Imamura M, Ohashi R, Jiang S, Tanaka T, Iwanari H, Hamakubo T, Sakai J, Kodama T, Naito M
Pathol Int. 2009
PubMed ID: 19261092
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Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice.
Zou Y, Du H, Yin M, Zhang L, Mao L, Xiao N, Ren G, Zhang C, Pan J
Mol Cell Biochem. 2009
PubMed ID: 19067122
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Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver.
Fernø J, Vik-Mo AO, Jassim G, Håvik B, Berge K, Skrede S, Gudbrandsen OA, Waage J, Lunder N, Mørk S, Berge RK, Jørgensen HA, Steen VM
Psychopharmacology (Berl). 2009
PubMed ID: 18989661
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Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c.
Qin Y, Dalen KT, Gustafsson JA, Nebb HI
Biochim Biophys Acta. 2009
PubMed ID: 19136075
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Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow.
Marathe C, Bradley MN, Hong C, Chao L, Wilpitz D, Salazar J, Tontonoz P
J Lipid Res. 2009
PubMed ID: 18772483
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Suppression of beta-catenin signaling by liver X receptor ligands.
Uno S, Endo K, Jeong Y, Kawana K, Miyachi H, Hashimoto Y, Makishima M
Biochem Pharmacol. 2009
PubMed ID: 18983830
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Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice.
Kim HJ, Andersson LC, Bouton D, Warner M, Gustafsson JA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19122149
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Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.
Dahlman I, Nilsson M, Gu HF, Lecoeur C, Efendic S, Ostenson CG, Brismar K, Gustafsson JA, Froguel P, Vaxillaire M, Dahlman-Wright K, Steffensen KR
BMC Med Genet. 2009
PubMed ID: 19292929
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Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L
Nat Genet. 2009
PubMed ID: 19060910
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Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary.
Matsumoto S, Hashimoto K, Yamada M, Satoh T, Hirato J, Mori M
Mol Endocrinol. 2009
PubMed ID: 19036902
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Liver X receptors (LXRalpha and LXRbeta) are potent regulators for hepatic Dec1 expression.
Noshiro M, Usui E, Kawamoto T, Sato F, Nakashima A, Ueshima T, Honda K, Fujimoto K, Honma S, Honma K, Makishima M, Kato Y
Genes Cells. 2009
PubMed ID: 19032342
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Improved lipid profile through liver-specific knockdown of liver X receptor alpha in KKAy diabetic mice.
Rippmann JF, Schoelch C, Nolte T, Pavliska H, van Marle A, van Es H, Prestle J
J Lipid Res. 2009
PubMed ID: 18769020
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The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo.
Astapova I, Lee LJ, Morales C, Tauber S, Bilban M, Hollenberg AN
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19052228
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25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.
Ma Y, Xu L, Rodriguez-Agudo D, Li X, Heuman DM, Hylemon PB, Pandak WM, Ren S
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18854425
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Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.
van Straten EM, Huijkman NC, Baller JF, Kuipers F, Plösch T
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18840761
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Effect of macrophage overexpression of murine liver X receptor-alpha (LXR-alpha) on atherosclerosis in LDL-receptor deficient mice.
Teupser D, Kretzschmar D, Tennert C, Burkhardt R, Wilfert W, Fengler D, Naumann R, Sippel AE, Thiery J
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18787185
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FXRalpha down-regulates LXRalpha signaling at the CETP promoter via a common element.
Park SS, Choi H, Kim SJ, Kim OJ, Chae KS, Kim E
Mol Cells. 2008
PubMed ID: 18562803
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Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment.
Phelan CA, Weaver JM, Steger DJ, Joshi S, Maslany JT, Collins JL, Zuercher WJ, Willson TM, Walker M, Jaye M, Lazar MA
Mol Endocrinol. 2008
PubMed ID: 18669643
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Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.
Colin S, Bourguignon E, Boullay AB, Tousaint JJ, Huet S, Caira F, Staels B, Lestavel S, Lobaccaro JM, Delerive P
Endocrinology. 2008
PubMed ID: 18566121
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Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression.
Gabbi C, Kim HJ, Hultenby K, Bouton D, Toresson G, Warner M, Gustafsson JA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18806227
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Lxralpha deficiency hampers the hepatic adaptive response to fasting in mice.
Oosterveer MH, van Dijk TH, Grefhorst A, Bloks VW, Havinga R, Kuipers F, Reijngoud DJ
J Biol Chem. 2008
PubMed ID: 18611859
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The nuclear receptor Rev-erbalpha is a liver X receptor (LXR) target gene driving a negative feedback loop on select LXR-induced pathways in human macrophages.
Fontaine C, Rigamonti E, Pourcet B, Duez H, Duhem C, Fruchart JC, Chinetti-Gbaguidi G, Staels B
Mol Endocrinol. 2008
PubMed ID: 18511497
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Androgen deprivation by activating the liver X receptor.
Lee JH, Gong H, Khadem S, Lu Y, Gao X, Li S, Zhang J, Xie W
Endocrinology. 2008
PubMed ID: 18450964
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Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
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LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P
Cell. 2008
PubMed ID: 18614014
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OSBP negatively regulates ABCA1 protein stability.
Bowden K, Ridgway ND
J Biol Chem. 2008
PubMed ID: 18450749
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Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1.
Imayama I, Ichiki T, Patton D, Inanaga K, Miyazaki R, Ohtsubo H, Tian Q, Yano K, Sunagawa K
Hypertension. 2008
PubMed ID: 18443233
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Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.
Lee S, Lee J, Lee SK, Lee JW
Mol Endocrinol. 2008
PubMed ID: 18372346
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Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Henry-Berger J, Mouzat K, Baron S, Bernabeu C, Marceau G, Saru JP, Sapin V, Lobaccaro JM, Caira F
Biol Reprod. 2008
PubMed ID: 18276933
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A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.
de Vogel-van den Bosch HM, de Wit NJ, Hooiveld GJ, Vermeulen H, van der Veen JN, Houten SM, Kuipers F, Müller M, van der Meer R
Am J Physiol Gastrointest Liver Physiol. 2008
PubMed ID: 18356535
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Regulation of SREBP1c gene expression in skeletal muscle: role of retinoid X receptor/liver X receptor and forkhead-O1 transcription factor.
Kamei Y, Miura S, Suganami T, Akaike F, Kanai S, Sugita S, Katsumata A, Aburatani H, Unterman TG, Ezaki O, Ogawa Y
Endocrinology. 2008
PubMed ID: 18202130
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LXRalpha enhances lipid synthesis in SZ95 sebocytes.
Hong I, Lee MH, Na TY, Zouboulis CC, Lee MO
J Invest Dermatol. 2008
PubMed ID: 17960176
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Protein kinase C alpha modulates liver X receptor alpha transactivation.
Delvecchio CJ, Capone JP
J Endocrinol. 2008
PubMed ID: 18372238
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Activation of liver X receptor sensitizes mice to gallbladder cholesterol crystallization.
Uppal H, Zhai Y, Gangopadhyay A, Khadem S, Ren S, Moser JA, Xie W
Hepatology. 2008
PubMed ID: 18318438
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Phosphorylation of liver X receptor alpha selectively regulates target gene expression in macrophages.
Torra IP, Ismaili N, Feig JE, Xu CF, Cavasotto C, Pancratov R, Rogatsky I, Neubert TA, Fisher EA, Garabedian MJ
Mol Cell Biol. 2008
PubMed ID: 18250151
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Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.
Wang H, Zhang Y, Yehuda-Shnaidman E, Medvedev AV, Kumar N, Daniel KW, Robidoux J, Czech MP, Mangelsdorf DJ, Collins S
Mol Cell Biol. 2008
PubMed ID: 18195045
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Liver X receptor is a key regulator of cytokine release in human monocytes.
Myhre AE, Agren J, Dahle MK, Tamburstuen MV, Lyngstadaas SP, Collins AJ, Foster SJ, Thiemermann C, Aasen AO, Wang JE
Shock. 2008
PubMed ID: 17724434
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Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice.
Dai X, Ou X, Hao X, Cao D, Tang Y, Hu Y, Li X, Tang C
Acta Biochim Biophys Sin (Shanghai). 2008
PubMed ID: 18330481
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C-reactive protein induces pro- and anti-inflammatory effects, including activation of the liver X receptor alpha, on human monocytes.
Hanriot D, Bello G, Ropars A, Seguin-Devaux C, Poitevin G, Grosjean S, Latger-Cannard V, Devaux Y, Zannad F, Regnault V, Lacolley P, Mertes PM, Hess K, Longrois D
Thromb Haemost. 2008
PubMed ID: 18327405
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ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver.
Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C
J Clin Invest. 2008
PubMed ID: 18292813
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Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations.
Legry V, Cottel D, Ferrières J, Chinetti G, Deroide T, Staels B, Amouyel P, Meirhaeghe A
Int J Obes (Lond). 2008
PubMed ID: 18209740
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Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.
Schmuth M, Jiang YJ, Dubrac S, Elias PM, Feingold KR
J Lipid Res. 2008
PubMed ID: 18182682
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Laminar shear stress regulates liver X receptor in vascular endothelial cells.
Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy JY, Zhu Y
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18096827
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Peroxisome proliferator-activated receptor alpha deficiency abolishes the response of lipogenic gene expression to re-feeding: restoration of the normal response by activation of liver X receptor alpha.
Hebbachi AM, Knight BL, Wiggins D, Patel DD, Gibbons GF
J Biol Chem. 2008
PubMed ID: 18079124
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Regulation of human 3 alpha-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor alpha.
Stayrook KR, Rogers PM, Savkur RS, Wang Y, Su C, Varga G, Bu X, Wei T, Nagpal S, Liu XS, Burris TP
Mol Pharmacol. 2008
PubMed ID: 18024509
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Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients.
Jiang ZY, Parini P, Eggertsen G, Davis MA, Hu H, Suo GJ, Zhang SD, Rudel LL, Han TQ, Einarsson C
J Lipid Res. 2008
PubMed ID: 18007013
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Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
PLoS ONE. 2008
PubMed ID: 18636124
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Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism.
Thornton SJ, Wong E, Lee SD, Wasan KM
Lipids Health Dis. 2008
PubMed ID: 18547429
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Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice.
Li Q, Chu MJ, Xu J
Mol Cell Biol. 2007
PubMed ID: 17908797
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Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse.
Valasek MA, Clarke SL, Repa JJ
J Lipid Res. 2007
PubMed ID: 17726195
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Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG
J Biol Chem. 2007
PubMed ID: 17766241
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Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL.
Buono C, Li Y, Waldo SW, Kruth HS
J Lipid Res. 2007
PubMed ID: 17693624
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The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor.
Herzog B, Hallberg M, Seth A, Woods A, White R, Parker MG
Mol Endocrinol. 2007
PubMed ID: 17684114
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SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L
Mol Cell. 2007
PubMed ID: 17936707
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27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Umetani M, Domoto H, Gormley AK, Yuhanna IS, Cummins CL, Javitt NB, Korach KS, Shaul PW, Mangelsdorf DJ
Nat Med. 2007
PubMed ID: 17873880
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Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit.
Russell LE, Harrison WJ, Bahta AW, Zouboulis CC, Burrin JM, Philpott MP
Exp Dermatol. 2007
PubMed ID: 17845217
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Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages.
Qiu G, Hill JS
J Lipid Res. 2007
PubMed ID: 17644777
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Liver X receptor-alpha gene expression is positively regulated by thyroid hormone.
Hashimoto K, Matsumoto S, Yamada M, Satoh T, Mori M
Endocrinology. 2007
PubMed ID: 17628006
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Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.
Bradley MN, Hong C, Chen M, Joseph SB, Wilpitz DC, Wang X, Lusis AJ, Collins A, Hseuh WA, Collins JL, Tangirala RK, Tontonoz P
J Clin Invest. 2007
PubMed ID: 17657314
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Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.
Liu QY, Quinet E, Nambi P
Mol Cell Biochem. 2007
PubMed ID: 17396233
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Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.
Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, Nagao T, Nishimaki-Mogami T
J Biol Chem. 2007
PubMed ID: 17526932
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Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140.
Jakobsson T, Osman W, Gustafsson JA, Zilliacus J, Wärnmark A
Biochem J. 2007
PubMed ID: 17391100
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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.
Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17563384
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Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway.
Chang L, Zhang Z, Li W, Dai J, Guan Y, Wang X
Biochem Biophys Res Commun. 2007
PubMed ID: 17445767
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The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells.
Chuu CP, Chen RY, Hiipakka RA, Kokontis JM, Warner KV, Xiang J, Liao S
Biochem Biophys Res Commun. 2007
PubMed ID: 17416342
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Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells.
Delvecchio CJ, Bilan P, Radford K, Stephen J, Trigatti BL, Cox G, Parameswaran K, Capone JP
Mol Endocrinol. 2007
PubMed ID: 17405904
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Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.
Geyeregger R, Zeyda M, Bauer W, Kriehuber E, Säemann MD, Zlabinger GJ, Maurer D, Stulnig TM
Blood. 2007
PubMed ID: 17255360
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Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility.
Volle DH, Mouzat K, Duggavathi R, Siddeek B, Déchelotte P, Sion B, Veyssière G, Benahmed M, Lobaccaro JM
Mol Endocrinol. 2007
PubMed ID: 17341595
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Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.
Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N
J Biol Chem. 2007
PubMed ID: 17296605
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Liver X receptor alpha associates with human life span.
Mooijaart SP, Kuningas M, Westendorp RG, Houwing-Duistermaat JJ, Slagboom PE, Rensen PC, van Heemst D
J Gerontol A Biol Sci Med Sci. 2007
PubMed ID: 17452725
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High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.
Nohara A, Kawashiri MA, Claudel T, Mizuno M, Tsuchida M, Takata M, Katsuda S, Miwa K, Inazu A, Kuipers F, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17272748
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ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP-binding cassette transporter A1.
Chen M, Li W, Wang N, Zhu Y, Wang X
Am J Physiol Cell Physiol. 2007
PubMed ID: 17135302
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Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol.
Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW
J Biol Chem. 2007
PubMed ID: 17186944
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Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus.
Mouzat K, Prod'homme M, Volle DH, Sion B, Déchelotte P, Gauthier K, Vanacker JM, Lobaccaro JM
J Biol Chem. 2007
PubMed ID: 17166844
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[The significance and effects of liver X receptor alpha in nonalcoholic fatty liver disease in rats]
Ai ZL, Chen DF
Zhonghua Gan Zang Bing Za Zhi. 2007
PubMed ID: 17362639
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Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.
Uppal H, Saini SP, Moschetta A, Mu Y, Zhou J, Gong H, Zhai Y, Ren S, Michalopoulos GK, Mangelsdorf DJ, Xie W
Hepatology. 2007
PubMed ID: 17256725
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LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.
Okuwaki M, Takada T, Iwayanagi Y, Koh S, Kariya Y, Fujii H, Suzuki H
Pharm Res. 2007
PubMed ID: 17177110
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Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha.
van der Veen JN, Havinga R, Bloks VW, Groen AK, Kuipers F
J Lipid Res. 2007
PubMed ID: 17088263
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Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.
Ghisletti S, Huang W, Ogawa S, Pascual G, Lin ME, Willson TM, Rosenfeld MG, Glass CK
Mol Cell. 2007
PubMed ID: 17218271
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The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.
Cha JY, Repa JJ
J Biol Chem. 2007
PubMed ID: 17107947
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The lipoprotein/lipid profile is modulated by a gene-diet interaction effect between polymorphisms in the liver X receptor-alpha and dietary cholesterol intake in French-Canadians.
Robitaille J, Houde A, Lemieux S, Gaudet D, Pérusse L, Vohl MC
Br J Nutr. 2007
PubMed ID: 17217555
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Lysophosphatidylcholine promotes cholesterol efflux from mouse macrophage foam cells via PPARgamma-LXRalpha-ABCA1-dependent pathway associated with apoE.
Hou M, Xia M, Zhu H, Wang Q, Li Y, Xiao Y, Zhao T, Tang Z, Ma J, Ling W
Cell Biochem Funct. 2007
PubMed ID: 16981222
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Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback.
Nilsson M, Stulnig TM, Lin CY, Yeo AL, Nowotny P, Liu ET, Steffensen KR
Mol Endocrinol. 2007
PubMed ID: 16973760
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A nuclear receptor corepressor-dependent pathway mediates suppression of cytokine-induced C-reactive protein gene expression by liver X receptor.
Blaschke F, Takata Y, Caglayan E, Collins A, Tontonoz P, Hsueh WA, Tangirala RK
Circ Res. 2006
PubMed ID: 17110595
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Inhibition of LXRalpha signaling by vitamin D receptor: possible role of VDR in bile acid synthesis.
Jiang W, Miyamoto T, Kakizawa T, Nishio SI, Oiwa A, Takeda T, Suzuki S, Hashizume K
Biochem Biophys Res Commun. 2006
PubMed ID: 17054913
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Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.
Dahlman I, Nilsson M, Jiao H, Hoffstedt J, Lindgren CM, Humphreys K, Kere J, Gustafsson JA, Arner P, Dahlman-Wright K
Pharmacogenet Genomics. 2006
PubMed ID: 17108812
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Importance of LXR-alpha transcriptome in the modulation of innate immunity.
Kaul D, Gautam A, Sikand K
Mol Cell Biochem. 2006
PubMed ID: 16758300
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The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
Reynolds WF, Kumar AP, Piedrafita FJ
Biochem Biophys Res Commun. 2006
PubMed ID: 16956579
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Selective LXRalpha inhibitory effects observed in plant extracts of MEH184 (Parthenocissua tricuspidata) and MEH185 (Euscaphis japonica).
Kim KH, Choi SH, Lee TS, Oh WK, Kim DS, Kim JB
Biochem Biophys Res Commun. 2006
PubMed ID: 16949052
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Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.
Hansmannel F, Mordier S, Iynedjian PB
Biochem J. 2006
PubMed ID: 16834571
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A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
Development. 2006
PubMed ID: 16971476
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Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.
Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P
Mol Pharmacol. 2006
PubMed ID: 16825483
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Improved metabolic control by depletion of Liver X Receptors in mice.
Schuster GU, Johansson L, Kietz S, Stulnig TM, Parini P, Gustafsson JA
Biochem Biophys Res Commun. 2006
PubMed ID: 16876124
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Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha.
Ishimoto K, Tachibana K, Sumitomo M, Omote S, Hanano I, Yamasaki D, Watanabe Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T
FEBS Lett. 2006
PubMed ID: 16920108
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Phosphorylation of the liver X receptors.
Chen M, Bradley MN, Beaven SW, Tontonoz P
FEBS Lett. 2006
PubMed ID: 16904112
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Stearoyl-coenzyme A desaturase 1 deficiency protects against hypertriglyceridemia and increases plasma high-density lipoprotein cholesterol induced by liver X receptor activation.
Chu K, Miyazaki M, Man WC, Ntambi JM
Mol Cell Biol. 2006
PubMed ID: 16943421
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Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol.
Hirayama T, Honda A, Matsuzaki Y, Miyazaki T, Ikegami T, Doy M, Xu G, Lea M, Salen G
Hepatology. 2006
PubMed ID: 16941710
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Investigation of the Lith1 candidate genes ABCB11 and LXRA in human gallstone disease.
Schafmayer C, Tepel J, Franke A, Buch S, Lieb S, Seeger M, Lammert F, Kremer B, Fölsch UR, Fändrich F, Schreiber S, Hampe J
Hepatology. 2006
PubMed ID: 16941683
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Abcg5/Abcg8-independent pathways contribute to hepatobiliary cholesterol secretion in mice.
Plösch T, van der Veen JN, Havinga R, Huijkman NC, Bloks VW, Kuipers F
Am J Physiol Gastrointest Liver Physiol. 2006
PubMed ID: 16614371
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Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes.
Steffensen KR, Robertson K, Gustafsson JA, Andersen CY
Mol Cell Endocrinol. 2006
PubMed ID: 16895745
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Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR.
Matsusue K, Miyoshi A, Yamano S, Gonzalez FJ
Mol Cell Endocrinol. 2006
PubMed ID: 16806672
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Cholesterol-sensing receptors, liver X receptor alpha and beta, have novel and distinct roles in osteoclast differentiation and activation.
Robertson KM, Norgård M, Windahl SH, Hultenby K, Ohlsson C, Andersson G, Gustafsson JA
J Bone Miner Res. 2006
PubMed ID: 16869726
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Liver X receptors regulate adrenal cholesterol balance.
Cummins CL, Volle DH, Zhang Y, McDonald JG, Sion B, Lefrançois-Martinez AM, Caira F, Veyssière G, Mangelsdorf DJ, Lobaccaro JM
J Clin Invest. 2006
PubMed ID: 16823488
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Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.
Aravindhan K, Webb CL, Jaye M, Ghosh A, Willette RN, DiNardo NJ, Jucker BM
J Lipid Res. 2006
PubMed ID: 16567856
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Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.
Cozzone D, Debard C, Dif N, Ricard N, Disse E, Vouillarmet J, Rabasa-Lhoret R, Laville M, Pruneau D, Rieusset J, Lefai E, Vidal H
Diabetologia. 2006
PubMed ID: 16482468
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Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice.
Lu W, Hisatsune A, Koga T, Kato K, Kuwahara I, Lillehoj EP, Chen W, Cross AS, Gendler SJ, Gewirtz AT, Kim KC
J Immunol. 2006
PubMed ID: 16547220
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Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
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In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Briançon N, Weiss MC
EMBO J. 2006
PubMed ID: 16498401
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Brain cholesterol turnover required for geranylgeraniol production and learning in mice.
Kotti TJ, Ramirez DM, Pfeiffer BE, Huber KM, Russell DW
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16505352
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Liver X receptors as integrators of metabolic and inflammatory signaling.
Zelcer N, Tontonoz P
J Clin Invest. 2006
PubMed ID: 16511593
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Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains.
Kobayashi M, Io F, Kawai T, Kumazawa M, Ikegami H, Nishimura M, Ohno T, Horio F
Diabetologia. 2006
PubMed ID: 16447060
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A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
Albers M, Blume B, Schlueter T, Wright MB, Kober I, Kremoser C, Deuschle U, Koegl M
J Biol Chem. 2006
PubMed ID: 16354658
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Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.
Lund EG, Peterson LB, Adams AD, Lam MH, Burton CA, Chin J, Guo Q, Huang S, Latham M, Lopez JC, Menke JG, Milot DP, Mitnaul LJ, Rex-Rabe SE, Rosa RL, Tian JY, Wright SD, Sparrow CP
Biochem Pharmacol. 2006
PubMed ID: 16325781
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Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes.
Uemura A, Kusuhara S, Wiegand SJ, Yu RT, Nishikawa S
J Clin Invest. 2006
PubMed ID: 16424942
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Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model.
Hashimoto K, Cohen RN, Yamada M, Markan KR, Monden T, Satoh T, Mori M, Wondisford FE
J Biol Chem. 2006
PubMed ID: 16260782
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation.
Weinhofer I, Kunze M, Rampler H, Bookout AL, Forss-Petter S, Berger J
J Biol Chem. 2005
PubMed ID: 16249184
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Topical liver x receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate.
Fluhr JW, Crumrine D, Mao-Qiang M, Moskowitz DG, Elias PM, Feingold KR
J Invest Dermatol. 2005
PubMed ID: 16354191
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Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
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Identification and characterization of two alternatively spliced transcript variants of human liver X receptor alpha.
Chen M, Beaven S, Tontonoz P
J Lipid Res. 2005
PubMed ID: 16170053
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Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha.
Hu T, Foxworthy P, Siesky A, Ficorilli JV, Gao H, Li S, Christe M, Ryan T, Cao G, Eacho P, Michael MD, Michael LF
Endocrinology. 2005
PubMed ID: 16123164
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Lack of stimulation of cholesteryl ester transfer protein by cholesterol in the presence of a high-fat diet.
Cheema SK, Agarwal-Mawal A, Murray CM, Tucker S
J Lipid Res. 2005
PubMed ID: 16106052
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Downregulation of liver X receptor-alpha in mouse kidney and HK-2 proximal tubular cells by LPS and cytokines.
Wang Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
J Lipid Res. 2005
PubMed ID: 16106051
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Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.
Grefhorst A, van Dijk TH, Hammer A, van der Sluijs FH, Havinga R, Havekes LM, Romijn JA, Groot PH, Reijngoud DJ, Kuipers F
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15941783
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Liver X receptor activation controls intracellular cholesterol trafficking and esterification in human macrophages.
Rigamonti E, Helin L, Lestavel S, Mutka AL, Lepore M, Fontaine C, Bouhlel MA, Bultel S, Fruchart JC, Ikonen E, Clavey V, Staels B, Chinetti-Gbaguidi G
Circ Res. 2005
PubMed ID: 16141411
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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.
Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Westin S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK
Cell. 2005
PubMed ID: 16143103
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.
Gnerre C, Schuster GU, Roth A, Handschin C, Johansson L, Looser R, Parini P, Podvinec M, Robertsson K, Gustafsson JA, Meyer UA
J Lipid Res. 2005
PubMed ID: 15930522
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Liver X receptors alpha and beta regulate renin expression in vivo.
Morello F, de Boer RA, Steffensen KR, Gnecchi M, Chisholm JW, Boomsma F, Anderson LM, Lawn RM, Gustafsson JA, Lopez-Ilasaca M, Pratt RE, Dzau VJ
J Clin Invest. 2005
PubMed ID: 16007255
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The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.
Robertson KM, Schuster GU, Steffensen KR, Hovatta O, Meaney S, Hultenby K, Johansson LC, Svechnikov K, Söder O, Gustafsson JA
Endocrinology. 2005
PubMed ID: 15761042
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Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.
Lehrke M, Lebherz C, Millington SC, Guan HP, Millar J, Rader DJ, Wilson JM, Lazar MA
Cell Metab. 2005
PubMed ID: 16054077
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LXRs regulate the balance between fat storage and oxidation.
Kalaany NY, Gauthier KC, Zavacki AM, Mammen PP, Kitazume T, Peterson JA, Horton JD, Garry DJ, Bianco AC, Mangelsdorf DJ
Cell Metab. 2005
PubMed ID: 16054068
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Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development.
Marceau G, Volle DH, Gallot D, Mangelsdorf DJ, Sapin V, Lobaccaro JM
Anat Rec A Discov Mol Cell Evol Biol. 2005
PubMed ID: 15674823
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Expression of the LXRalpha protein in human atherosclerotic lesions.
Watanabe Y, Jiang S, Takabe W, Ohashi R, Tanaka T, Uchiyama Y, Katsumi K, Iwanari H, Noguchi N, Naito M, Hamakubo T, Kodama T
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15625283
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Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells.
Davies JD, Carpenter KL, Challis IR, Figg NL, McNair R, Proudfoot D, Weissberg PL, Shanahan CM
J Biol Chem. 2005
PubMed ID: 15548517
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Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, Kern R, Koegl M
Mol Cell Proteomics. 2005
PubMed ID: 15604093
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Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM
Cell. 2005
PubMed ID: 15680331
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Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c.
Hegarty BD, Bobard A, Hainault I, Ferré P, Bossard P, Foufelle F
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15637161
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Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
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Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350.
Patel H, Truant R, Rachubinski RA, Capone JP
J Cell Sci. 2005
PubMed ID: 15615782
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Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
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Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.
Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15601766
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Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.
Blaschke F, Leppanen O, Takata Y, Caglayan E, Liu J, Fishbein MC, Kappert K, Nakayama KI, Collins AR, Fleck E, Hsueh WA, Law RE, Bruemmer D
Circ Res. 2004
PubMed ID: 15539633
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Genome-wide expression profiling; a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals.
Steffensen KR, Neo SY, Stulnig TM, Vega VB, Rahman SS, Schuster GU, Gustafsson JA, Liu ET
J Mol Endocrinol. 2004
PubMed ID: 15591022
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Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver.
Anderson SP, Dunn C, Laughter A, Yoon L, Swanson C, Stulnig TM, Steffensen KR, Chandraratna RA, Gustafsson JA, Corton JC
Mol Pharmacol. 2004
PubMed ID: 15371561
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Unliganded thyroid hormone receptor-beta1 represses liver X receptor alpha/oxysterol-dependent transactivation.
Kawai K, Sasaki S, Morita H, Ito T, Suzuki S, Misawa H, Nakamura H
Endocrinology. 2004
PubMed ID: 15319359
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Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue.
Ulven SM, Dalen KT, Gustafsson JA, Nebb HI
J Lipid Res. 2004
PubMed ID: 15292368
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Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein.
Nakamura K, Kennedy MA, Baldán A, Bojanic DD, Lyons K, Edwards PA
J Biol Chem. 2004
PubMed ID: 15319426
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LXR-dependent gene expression is important for macrophage survival and the innate immune response.
Joseph SB, Bradley MN, Castrillo A, Bruhn KW, Mak PA, Pei L, Hogenesch J, O'connell RM, Cheng G, Saez E, Miller JF, Tontonoz P
Cell. 2004
PubMed ID: 15479645
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Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.
Frenoux JM, Vernet P, Volle DH, Britan A, Saez F, Kocer A, Henry-Berger J, Mangelsdorf DJ, Lobaccaro JM, Drevet JR
J Mol Endocrinol. 2004
PubMed ID: 15525595
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Human ORFeome version 1.1: a platform for reverse proteomics.
Rual JF, Hirozane-Kishikawa T, Hao T, Bertin N, Li S, Dricot A, Li N, Rosenberg J, Lamesch P, Vidalain PO, Clingingsmith TR, Hartley JL, Esposito D, Cheo D, Moore T, Simmons B, Sequerra R, Bosak S, Doucette-Stamm L, Le Peuch C, Vandenhaute J, Cusick ME, Albala JS, Hill DE, Vidal M
Genome Res. 2004
PubMed ID: 15489335
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Nuclear receptor LXRalpha is involved in cAMP-mediated human renin gene expression.
Tamura K, Chen YE, Tanaka Y, Sakai M, Tsurumi Y, Koide Y, Kihara M, Pratt RE, Horiuchi M, Umemura S, Dzau VJ
Mol Cell Endocrinol. 2004
PubMed ID: 15353176
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Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
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Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.
Chen G, Liang G, Ou J, Goldstein JL, Brown MS
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15266058
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Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue.
Lundholm L, Movérare S, Steffensen KR, Nilsson M, Otsuki M, Ohlsson C, Gustafsson JA, Dahlman-Wright K
J Mol Endocrinol. 2004
PubMed ID: 15171719
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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J
J Clin Invest. 2004
PubMed ID: 15146238
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Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor gamma expression.
Seo JB, Moon HM, Kim WS, Lee YS, Jeong HW, Yoo EJ, Ham J, Kang H, Park MG, Steffensen KR, Stulnig TM, Gustafsson JA, Park SD, Kim JB
Mol Cell Biol. 2004
PubMed ID: 15060163
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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Expression of the liver X receptor alpha and beta in embryonic and adult mice.
Annicotte JS, Schoonjans K, Auwerx J
Anat Rec A Discov Mol Cell Evol Biol. 2004
PubMed ID: 15052659
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Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes.
Volle DH, Repa JJ, Mazur A, Cummins CL, Val P, Henry-Berger J, Caira F, Veyssiere G, Mangelsdorf DJ, Lobaccaro JM
Mol Endocrinol. 2004
PubMed ID: 14739254
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Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target.
Hummasti S, Laffitte BA, Watson MA, Galardi C, Chao LC, Ramamurthy L, Moore JT, Tontonoz P
J Lipid Res. 2004
PubMed ID: 14703507
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Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.
Walczak R, Joseph SB, Laffitte BA, Castrillo A, Pei L, Tontonoz P
J Biol Chem. 2004
PubMed ID: 14699103
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Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse.
Masson D, Staels B, Gautier T, Desrumaux C, Athias A, Le Guern N, Schneider M, Zak Z, Dumont L, Deckert V, Tall A, Jiang XC, Lagrost L
J Lipid Res. 2004
PubMed ID: 14679166
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.
Plösch T, Bloks VW, Terasawa Y, Berdy S, Siegler K, Van Der Sluijs F, Kema IP, Groen AK, Shan B, Kuipers F, Schwarz M, Schwartz M
Gastroenterology. 2004
PubMed ID: 14699507
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Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression.
Jiang XC, Beyer TP, Li Z, Liu J, Quan W, Schmidt RJ, Zhang Y, Bensch WR, Eacho PI, Cao G
J Biol Chem. 2003
PubMed ID: 12947111
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Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha.
Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI
J Biol Chem. 2003
PubMed ID: 12970362
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Molecular determinants of LXRalpha agonism.
Wang M, Thomas J, Burris TP, Schkeryantz J, Michael LF
J Mol Graph Model. 2003
PubMed ID: 12932788
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Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively.
Steffensen KR, Nilsson M, Schuster GU, Stulnig TM, Dahlman-Wright K, Gustafsson JA
Biochem Biophys Res Commun. 2003
PubMed ID: 14521951
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The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression.
Pawar A, Botolin D, Mangelsdorf DJ, Jump DB
J Biol Chem. 2003
PubMed ID: 12917410
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Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors.
Miyazaki M, Jacobson MJ, Man WC, Cohen P, Asilmaz E, Friedman JM, Ntambi JM
J Biol Chem. 2003
PubMed ID: 12815040
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Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.
Fukuchi J, Song C, Ko AL, Liao S
Steroids. 2003
PubMed ID: 12957674
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Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass CK
Mol Cell Biol. 2003
PubMed ID: 12897148
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Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N
Mol Endocrinol. 2003
PubMed ID: 12730332
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Liver X receptors interact with corepressors to regulate gene expression.
Hu X, Li S, Wu J, Xia C, Lala DS
Mol Endocrinol. 2003
PubMed ID: 12663743
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Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.
Yu L, York J, von Bergmann K, Lutjohann D, Cohen JC, Hobbs HH
J Biol Chem. 2003
PubMed ID: 12601003
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Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
Kim SW, Park K, Kwak E, Choi E, Lee S, Ham J, Kang H, Kim JM, Hwang SY, Kong YY, Lee K, Lee JW
Mol Cell Biol. 2003
PubMed ID: 12724417
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Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice.
Lyons MA, Wittenburg H, Li R, Walsh KA, Churchill GA, Carey MC, Paigen B
J Lipid Res. 2003
PubMed ID: 12588951
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Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism.
Anderson LM, Choe SE, Yukhananov RY, Hopfner RL, Church GM, Pratt RE, Dzau VJ
J Biol Chem. 2003
PubMed ID: 12551904
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Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha.
Oberkofler H, Schraml E, Krempler F, Patsch W
Biochem J. 2003
PubMed ID: 12470296
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Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages.
Castrillo A, Joseph SB, Marathe C, Mangelsdorf DJ, Tontonoz P
J Biol Chem. 2003
PubMed ID: 12531895
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The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.
Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, Wilpitz D, Mangelsdorf D, Tontonoz P
Mol Cell Biol. 2003
PubMed ID: 12612088
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On the role of liver X receptors in lipid accumulation in adipocytes.
Juvet LK, Andresen SM, Schuster GU, Dalen KT, Tobin KA, Hollung K, Haugen F, Jacinto S, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI
Mol Endocrinol. 2003
PubMed ID: 12554745
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Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
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J Invest Dermatol. 2003
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Reciprocal regulation of inflammation and lipid metabolism by liver X receptors.
Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P
Nat Med. 2003
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Regulation of the angiopoietin-like protein 3 gene by LXR.
Kaplan R, Zhang T, Hernandez M, Gan FX, Wright SD, Waters MG, Cai TQ
J Lipid Res. 2003
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross.
Sehayek E, Duncan EM, Lutjohann D, Von Bergmann K, Ono JG, Batta AK, Salen G, Breslow JL
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12446833
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
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Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue.
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Mol Pharmacol. 2002
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Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.
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J Biol Chem. 2002
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Phospholipid transfer protein is regulated by liver X receptors in vivo.
Cao G, Beyer TP, Yang XP, Schmidt RJ, Zhang Y, Bensch WR, Kauffman RF, Gao H, Ryan TP, Liang Y, Eacho PI, Jiang XC
J Biol Chem. 2002
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Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells.
Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB
J Biol Chem. 2002
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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration.
Wang L, Schuster GU, Hultenby K, Zhang Q, Andersson S, Gustafsson JA
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12368482
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Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.
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J Biol Chem. 2002
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Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles.
Grefhorst A, Elzinga BM, Voshol PJ, Plösch T, Kok T, Bloks VW, van der Sluijs FH, Havekes LM, Romijn JA, Verkade HJ, Kuipers F
J Biol Chem. 2002
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Identification of macrophage liver X receptors as inhibitors of atherosclerosis.
Tangirala RK, Bischoff ED, Joseph SB, Wagner BL, Walczak R, Laffitte BA, Daige CL, Thomas D, Heyman RA, Mangelsdorf DJ, Wang X, Lusis AJ, Tontonoz P, Schulman IG
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12193651
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The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.
Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J
Mol Endocrinol. 2002
PubMed ID: 12198243
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Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA
J Biol Chem. 2002
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Accumulation of foam cells in liver X receptor-deficient mice.
Schuster GU, Parini P, Wang L, Alberti S, Steffensen KR, Hansson GK, Angelin B, Gustafsson JA
Circulation. 2002
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Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.
Stulnig TM, Oppermann U, Steffensen KR, Schuster GU, Gustafsson JA
Diabetes. 2002
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Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism.
Ross SE, Erickson RL, Gerin I, DeRose PM, Bajnok L, Longo KA, Misek DE, Kuick R, Hanash SM, Atkins KB, Andresen SM, Nebb HI, Madsen L, Kristiansen K, MacDougald OA
Mol Cell Biol. 2002
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The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter.
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Biochim Biophys Acta. 2002
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Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha.
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Diabetes. 2002
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Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.
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Mol Endocrinol. 2002
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Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
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Mol Endocrinol. 2002
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Different regulation of the LXRalpha promoter activity by isoforms of CCAAT/enhancer-binding proteins.
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Biochem Biophys Res Commun. 2002
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Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.
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J Biol Chem. 2002
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LXR alpha is the dominant regulator of CYP7A1 transcription.
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Biochem Biophys Res Commun. 2002
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Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis.
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J Biol Chem. 2002
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Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.
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Mol Endocrinol. 2002
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The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.
Phan J, Pesaran T, Davis RC, Reue K
J Biol Chem. 2002
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Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis.
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J Invest Dermatol. 2002
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BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis.
Edwards PA, Kast HR, Anisfeld AM
J Lipid Res. 2002
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Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.
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J Biol Chem. 2001
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Genetic analysis of intestinal cholesterol absorption in inbred mice.
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J Lipid Res. 2001
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Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice.
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J Clin Invest. 2001
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Nature. 2001
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LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.
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Proc Natl Acad Sci U S A. 2001
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Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
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Gene. 2001
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Gastroenterology. 2001
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Genes Dev. 2000
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Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
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Genes Dev. 2000
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Proc Natl Acad Sci U S A. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
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Science. 2000
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Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
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Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
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Mol Cell Endocrinol. 1998
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