NR2E3

Summary Top Help

Gene Description:

nuclear receptor subfamily 2, group E, member 3; nuclear receptor subfamily 2, group E, member 3-like

Synonyms:

rd7, ESCS, Nr2e3, RP37, NR2E3, LOC100365683, RNR, A930035N01Rik, PNR

Orthologs:

Human NR2E3 (protein-coding), Mouse Nr2e3 (protein-coding), Rat LOC100365683 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr15:72084977..72110600 (25.62 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:59790578..59808466 (17.89 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for NR2E3:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for NR2E3:

The NR2E3 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
NR2E3	CDK9	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	IRF9	BioGRID	empirical	20211142
NR2E3	MYBBP1A	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	TBL3	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	CRX	HPRD	empirical	15689355
NR2E3	DEDD2	BioGRID	empirical	20211142
NR2E3	E2F4	MINT	empirical	17255935
NR2E3	ELAVL2	BioGRID	empirical	20211142
NR2E3	DHX30	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	RBFOX2	BioGRID	empirical	20211142
NR2E3	SIN3A	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	NR3C1	BioGRID	empirical	20211142
NR2E3	HDAC1	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	HOXC13	BioGRID	empirical	20211142
NR2E3	MED1	Reactome	predicted	10542397 10235266 16751179 15896744 15175151 11865025 9653119
NR2E3	RARA	HPRD, BioGRID	empirical	10611353
NR2E3	RBBP4	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	RBBP7	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	RBL1	HPRD, MINT	empirical	17255935
NR2E3	RXRA	BioGRID	empirical	10611353
NR2E3	RXRB	HPRD	empirical	10611353
NR2E3	POLR3D	BioGRID	empirical	20211142
NR2E3	SNAPC1	BioGRID	empirical	20211142
NR2E3	VDR	BioGRID	empirical	15919092
NR2E3	ZNF232	BioGRID	empirical	20211142
NR2E3	HDAC3	HPRD, MINT, BioGRID	empirical	17255935
NR2E3	NR1D1	HPRD	empirical	15190009
NR2E3	NCOR1	HPRD, MINT, BioGRID	empirical	17255935

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: 3

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 17

Publications from PubMed Top Help

Publications: 82

Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation.
Wen Z, Pyeon D, Wang Y, Lambert P, Xu W, Ahlquist P
Mol Cell Biol. 2012
PubMed ID: 22025681
Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.
Cheng H, Khan NW, Roger JE, Swaroop A
Hum Mol Genet. 2011
PubMed ID: 21813656
Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network.
Peng GH, Chen S
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22006320
A novel mutation (Cys83Tyr) in the second zinc finger of NR2E3 in enhanced S-cone syndrome.
Rocha-Sousa A, Hayashi T, Gomes NL, Penas S, Brandão E, Rocha P, Urashima M, Yamada H, Tsuneoka H, Falcão-Reis F
Graefes Arch Clin Exp Ophthalmol. 2011
PubMed ID: 20725840
Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina.
Mollema NJ, Yuan Y, Jelcick AS, Sachs AJ, von Alpen D, Schorderet D, Escher P, Haider NB
PLoS One. 2011
PubMed ID: 21408158
Developmental or degenerative--NR2E3 gene mutations in two patients with enhanced S cone syndrome.
Udar N, Small K, Chalukya M, Silva-Garcia R, Marmor M
Mol Vis. 2011
PubMed ID: 21364904
Mouse model resources for vision research.
Won J, Shi LY, Hicks W, Wang J, Hurd R, Naggert JK, Chang B, Nishina PM
J Ophthalmol. 2011
PubMed ID: 21052544
Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
Gene Expr Patterns. 2011
PubMed ID: 20932939
DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina.
Shi M, Zheng MH, Liu ZR, Hu ZL, Huang Y, Chen JY, Zhao G, Han H, Ding YQ
Dev Biol. 2010
PubMed ID: 20875817
Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa.
Clark GR, Crowe P, Muszynska D, O'Prey D, O'Neill J, Alexander S, Willoughby CE, McKay GJ, Silvestri G, Simpson DA
Ophthalmology. 2010
PubMed ID: 20591486
Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip.
Booij JC, Bakker A, Kulumbetova J, Moutaoukil Y, Smeets B, Verheij J, Kroes HY, Klaver CC, van Schooneveld M, Bergen AA, Florijn RJ
Ophthalmology. 2010
PubMed ID: 20801516
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
Association of NR2E3 but not NRL mutations with retinitis pigmentosa in the Chinese population.
Yang Y, Zhang X, Chen LJ, Chiang SW, Tam PO, Lai TY, Chan CK, Wang N, Lam DS, Pang CP
Invest Ophthalmol Vis Sci. 2010
PubMed ID: 19933183
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Helicoid subretinal fibrosis associated with a novel recessive NR2E3 mutation p.S44X.
Khan AO, Aldahmesh MA, Al-Harthi E, Alkuraya FS
Arch Ophthalmol. 2010
PubMed ID: 20212206
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
NR2E3 mutations in enhanced S-cone sensitivity syndrome (ESCS), Goldmann-Favre syndrome (GFS), clumped pigmentary retinal degeneration (CPRD), and retinitis pigmentosa (RP).
Schorderet DF, Escher P
Hum Mutat. 2009
PubMed ID: 19718767
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.
Riesenberg AN, Liu Z, Kopan R, Brown NL
J Neurosci. 2009
PubMed ID: 19828801
Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development.
Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805139
Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction.
Haider NB, Mollema N, Gaule M, Yuan Y, Sachs AJ, Nystuen AM, Naggert JK, Nishina PM
Exp Eye Res. 2009
PubMed ID: 19379737
Dual transgene strategy for live visualization of chromatin and plasma membrane dynamics in murine embryonic stem cells and embryonic tissues.
Nowotschin S, Eakin GS, Hadjantonakis AK
Genesis. 2009
PubMed ID: 19358158
The spectrum of retinal diseases caused by NR2E3 mutations in Israeli and Palestinian patients.
Bandah D, Merin S, Ashhab M, Banin E, Sharon D
Arch Ophthalmol. 2009
PubMed ID: 19273793
Mutations in NR2E3 can cause dominant or recessive retinal degenerations in the same family.
Escher P, Gouras P, Roduit R, Tiab L, Bolay S, Delarive T, Chen S, Tsai CC, Hayashi M, Zernant J, Merriam JE, Mermod N, Allikmets R, Munier FL, Schorderet DF
Hum Mutat. 2009
PubMed ID: 19006237
Pias3-dependent SUMOylation directs rod photoreceptor development.
Onishi A, Peng GH, Hsu C, Alexis U, Chen S, Blackshaw S
Neuron. 2009
PubMed ID: 19186166
A comprehensive analysis of sequence variants and putative disease-causing mutations in photoreceptor-specific nuclear receptor NR2E3.
Kanda A, Swaroop A
Mol Vis. 2009
PubMed ID: 19898638
Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.
Roduit R, Escher P, Schorderet DF
PLoS One. 2009
PubMed ID: 19823680
Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells.
Das G, Choi Y, Sicinski P, Levine EM
Neural Dev. 2009
PubMed ID: 19416500
Phenotypic features of patients with NR2E3 mutations.
Pachydaki SI, Klaver CC, Barbazetto IA, Roy MS, Gouras P, Allikmets R, Yannuzzi LA
Arch Ophthalmol. 2009
PubMed ID: 19139342
Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons.
Kanadia RN, Clark VE, Punzo C, Trimarchi JM, Cepko CL
Development. 2008
PubMed ID: 18987029
Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors.
Oh EC, Cheng H, Hao H, Jia L, Khan NW, Swaroop A
Brain Res. 2008
PubMed ID: 18294621
A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer-segment defects similar to Nr2e3 ( rd7/rd7 ) retinas.
Nystuen AM, Sachs AJ, Yuan Y, Heuermann L, Haider NB
Mamm Genome. 2008
PubMed ID: 18763016
Dual role of Nr2e3 in photoreceptor development and maintenance.
Webber AL, Hodor P, Thut CJ, Vogt TF, Zhang T, Holder DJ, Petrukhin K
Exp Eye Res. 2008
PubMed ID: 18547563
Phenotypic variation in enhanced S-cone syndrome.
Audo I, Michaelides M, Robson AG, Hawlina M, Vaclavik V, Sandbach JM, Neveu MM, Hogg CR, Hunt DM, Moore AT, Bird AC, Webster AR, Holder GE
Invest Ophthalmol Vis Sci. 2008
PubMed ID: 18436841
Analysis of the involvement of the NR2E3 gene in autosomal recessive retinal dystrophies.
Bernal S, Solans T, Gamundi MJ, Hernan I, de Jorge L, Carballo M, Navarro R, Tizzano E, Ayuso C, Baiget M
Clin Genet. 2008
PubMed ID: 18294254
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Mapping of genetic modifiers of Nr2e3 rd7/rd7 that suppress retinal degeneration and restore blue cone cells to normal quantity.
Haider NB, Zhang W, Hurd R, Ikeda A, Nystuen AM, Naggert JK, Nishina PM
Mamm Genome. 2008
PubMed ID: 18286335
Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa.
Coppieters F, Leroy BP, Beysen D, Hellemans J, De Bosscher K, Haegeman G, Robberecht K, Wuyts W, Coucke PJ, De Baere E
Am J Hum Genet. 2007
PubMed ID: 17564971
Genetic ablation of cone photoreceptors eliminates retinal folds in the retinal degeneration 7 (rd7) mouse.
Chen J, Nathans J
Invest Ophthalmol Vis Sci. 2007
PubMed ID: 17525215
A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
Takezawa S, Yokoyama A, Okada M, Fujiki R, Iriyama A, Yanagi Y, Ito H, Takada I, Kishimoto M, Miyajima A, Takeyama K, Umesono K, Kitagawa H, Kato S
EMBO J. 2007
PubMed ID: 17255935
The Gly56Arg mutation in NR2E3 accounts for 1-2% of autosomal dominant retinitis pigmentosa.
Gire AI, Sullivan LS, Bowne SJ, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP
Mol Vis. 2007
PubMed ID: 17982421
The cis-regulatory logic of the mammalian photoreceptor transcriptional network.
Hsiau TH, Diaconu C, Myers CA, Lee J, Cepko CL, Corbo JC
PLoS ONE. 2007
PubMed ID: 17653270
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
The transcription factor Nr2e3 functions in retinal progenitors to suppress cone cell generation.
Haider NB, Demarco P, Nystuen AM, Huang X, Smith RS, McCall MA, Naggert JK, Nishina PM
Vis Neurosci. 2006
PubMed ID: 17266784
A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
Development. 2006
PubMed ID: 16971476
In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.
Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A
Hum Mol Genet. 2006
PubMed ID: 16868010
Spatial and temporal expression profile of pinin during mouse development.
Leu S, Ouyang P
Gene Expr Patterns. 2006
PubMed ID: 16427813
Effects of L1 retrotransposon insertion on transcript processing, localization and accumulation: lessons from the retinal degeneration 7 mouse and implications for the genomic ecology of L1 elements.
Chen J, Rattner A, Nathans J
Hum Mol Genet. 2006
PubMed ID: 16723373
Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.
Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM
Genes Dev. 2006
PubMed ID: 16702404
Notch 1 inhibits photoreceptor production in the developing mammalian retina.
Jadhav AP, Mason HA, Cepko CL
Development. 2006
PubMed ID: 16452096
Novel NR2E3 mutations (R104Q, R334G) associated with a mild form of enhanced S-cone syndrome demonstrate compound heterozygosity.
Hayashi T, Gekka T, Goto-Omoto S, Takeuchi T, Kubo A, Kitahara K
Ophthalmology. 2005
PubMed ID: 16225923
Physiological function of S-cone system is not enhanced in rd7 mice.
Ueno S, Kondo M, Miyata K, Hirai T, Miyata T, Usukura J, Nishizawa Y, Miyake Y
Exp Eye Res. 2005
PubMed ID: 16005871
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Mouse models of ocular diseases.
Chang B, Hawes NL, Hurd RE, Wang J, Howell D, Davisson MT, Roderick TH, Nusinowitz S, Heckenlively JR
Vis Neurosci. 2005
PubMed ID: 16332269
A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome.
Corbo JC, Cepko CL
PLoS Genet. 2005
PubMed ID: 16110338
Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3.
Väisänen S, Dunlop TW, Sinkkonen L, Frank C, Carlberg C
J Mol Biol. 2005
PubMed ID: 15919092
The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
Peng GH, Ahmad O, Ahmad F, Liu J, Chen S
Hum Mol Genet. 2005
PubMed ID: 15689355
The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes.
Chen J, Rattner A, Nathans J
J Neurosci. 2005
PubMed ID: 15634773
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Mutation analysis of NR2E3 and NRL genes in Enhanced S Cone Syndrome.
Wright AF, Reddick AC, Schwartz SB, Ferguson JS, Aleman TS, Kellner U, Jurklies B, Schuster A, Zrenner E, Wissinger B, Lennon A, Shu X, Cideciyan AV, Stone EM, Jacobson SG, Swaroop A
Hum Mutat. 2004
PubMed ID: 15459973
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
Expression of photoreceptor-specific nuclear receptor NR2E3 in rod photoreceptors of fetal human retina.
Bumsted O'Brien KM, Cheng H, Jiang Y, Schulte D, Swaroop A, Hendrickson AE
Invest Ophthalmol Vis Sci. 2004
PubMed ID: 15277507
Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors.
Cheng H, Khanna H, Oh EC, Hicks D, Mitton KP, Swaroop A
Hum Mol Genet. 2004
PubMed ID: 15190009
Shared mutations in NR2E3 in enhanced S-cone syndrome, Goldmann-Favre syndrome, and many cases of clumped pigmentary retinal degeneration.
Sharon D, Sandberg MA, Caruso RC, Berson EL, Dryja TP
Arch Ophthalmol. 2003
PubMed ID: 12963616
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.
Yanagi Y, Takezawa S, Kato S
Invest Ophthalmol Vis Sci. 2002
PubMed ID: 12407160
Retinal degeneration mutants in the mouse.
Chang B, Hawes NL, Hurd RE, Davisson MT, Nusinowitz S, Heckenlively JR
Vision Res. 2002
PubMed ID: 11853768
The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration.
Milam AH, Rose L, Cideciyan AV, Barakat MR, Tang WX, Gupta N, Aleman TS, Wright AF, Stone EM, Sheffield VC, Jacobson SG
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11773633
Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice.
Haider NB, Naggert JK, Nishina PM
Hum Mol Genet. 2001
PubMed ID: 11487564
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The photoreceptor cell-specific nuclear receptor gene (PNR) accounts for retinitis pigmentosa in the Crypto-Jews from Portugal (Marranos), survivors from the Spanish Inquisition.
Gerber S, Rozet JM, Takezawa SI, dos Santos LC, Lopes L, Gribouval O, Penet C, Perrault I, Ducroq D, Souied E, Jeanpierre M, Romana S, Frézal J, Ferraz F, Yu-Umesono R, Munnich A, Kaplan J
Hum Genet. 2000
PubMed ID: 11071390
A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.
Akhmedov NB, Piriev NI, Chang B, Rapoport AL, Hawes NL, Nishina PM, Nusinowitz S, Heckenlively JR, Roderick TH, Kozak CA, Danciger M, Davisson MT, Farber DB
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10805811
Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.
Haider NB, Jacobson SG, Cideciyan AV, Swiderski R, Streb LM, Searby C, Beck G, Hockey R, Hanna DB, Gorman S, Duhl D, Carmi R, Bennett J, Weleber RG, Fishman GA, Wright AF, Stone EM, Sheffield VC
Nat Genet. 2000
PubMed ID: 10655056
Assignment of the NR2E3 gene to mouse chromosome 9 and to human chromosome 15q22.33-->q23.
Rendtorff ND, Vissing H, Tümer Z, Silahtaroglu A, Tommerup N
Cytogenet Cell Genet. 2000
PubMed ID: 10965145
Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells.
Chen F, Figueroa DJ, Marmorstein AD, Zhang Q, Petrukhin K, Caskey CT, Austin CP
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10611353
Mouse fundus photography and angiography: a catalogue of normal and mutant phenotypes.
Hawes NL, Smith RS, Chang B, Davisson M, Heckenlively JR, John SW
Mol Vis. 1999
PubMed ID: 10493779
Identification of a photoreceptor cell-specific nuclear receptor.
Kobayashi M, Takezawa S, Hara K, Yu RT, Umesono Y, Agata K, Taniwaki M, Yasuda K, Umesono K
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10220376
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636

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	Human	Mouse	Rat
Entrez Gene	10002	23958	100365683
EnsEMBL Gene(s)	N/A	ENSMUSG00000032292	N/A
Unigene	Hs.187354	Mm.103641	N/A
Homologene	NR2E3	Nr2e3	LOC100365683
OMIM	604485	N/A	N/A
GeneCards	NR2E3	N/A	N/A
Beta Cell Genomics	DT.92024699 DT.97770975 DT.97836583	DT.101302896 DT.101349738 DT.101731660 DT.87056518 DT.91318774 DT.97411780	N/A
Reactome	Q9Y5X4	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	10002	23958	100365683

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