To further Type 1 diabetes research congenic mouse strains have been created to help identify
regions of the NOD genome implicated in the disease. This tool allows users to search,
compare and visualise strains that are available within T1DBase.
Operating Instructions:
To run this program please specify one or more search terms in the 'Create Query' section and click the "Submit Query" button. Search terms may include one or more of the following :-
- Strain name (including donor strain e.g. b6)
- Taconic identifier
- Jackson Laboratory identifier
- Chromosome
- Marker
- Gene
- Idd region
Additionally searching using a wildcard character (*) is possible when using strain names, region and Chromosome identifiers.
Results page:
All results are returned with respect to NCBIM37.
The section Strain Summary shows a tabularised overview of those strains that fulfilled search criteria.
The section Strain Visualisation presents a static graphical representation of queried strains.
The region of DNA that is introgressed into the NOD background is shown in blue,
boundary markers are coloured green if they are of the donor haplotype and red if NOD.
If more than one strain is selected for a particular chromosome the scale is adjusted to allow comparisons to be made.
Both sections include links to genome browser tool for further data integration and interrogation.
Please see GBrowse instructions for further details.
Scientific details:
Congenic strains are produced by repeated backcrosses to an inbred (background) strain,
with selection for a particular marker from the donor strain (Snell 1978, Flaherty 1981).
References:
Snell GD. 1978. Congenic resistant strains of mice. In Origins of Inbred Mice, Morse HC (ed.), Academic Press, New York, pp. 1-31.
Flaherty L. 1981. Congenic strains. In The Mouse in Biomedical Research, Vol. 1, Foster HL, Small JD, Fox JG (eds.), Academic Press, New York, pp. 215-222.
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